Dr. Brij Bhan Singh
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Dr. Brij Bhan Singh

Professor
Department of Biochemistry and Molecular Biology, University of North Dakota, USA


Highest Degree
Ph.D. in Biochemistry and Molecular Biology from University of Bonn, Germany

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Biography

Dr. Brij B. Singh is currently working as Professor and Interim Associate Dean for Research Department of Basic Biomedical Science, School of Medicine and Health Sciences. He obtained his PhD in Biochemistry from Bhopal University India and the University of Bonn Germany in 1997, M.S. in Biotechnology from Aligarh University (AMU), Aligarh India in 1993. In past he worked as DAAD Fellow laboratory of Molecular Biochemistry at University of Bonn Germany, Research Fellow at Therapeutics at Medical College of Wisconsin Milwaukee WI and Gene Therapy & Therapeutics Branch National Institutes of Dental and Craniofacial Research, Assistant Professor and then Professor at University of North Dakota. Dr. Brij B. Singh is also pursuing professional membership i.e. New York Academy of Sciences, North Dakota Academy of Sciences, American Society of Biochemistry and Molecular Biology, American Society of Advancement of Sciences, American Society of Cell Biology, Sigma Xi. He is a member of editorial board and reviewer of many journals. He has been invited to delivered special lectures in many national and international conferences and workshops. He actively participated in number of conferences and professional meetings. He supervised 2 PhD students and 1 MS student, 2 PhD students are currently under his supervision. Dr. Brij B. Singh received a number of honors include North Dakota Spirit Award, five year renewal of the NIH R01 grant, Dean H David Wilson Academic Award, School of Medicine and Health Sciences Grant Achievement Award, North Dakota Spirit Award, Funding for a five year NIH program project grant, Five year NIH R01 award, Fellowship award in recognition of outstanding research in oral and craniofacial health and disease, Competitive Travel Award for the year 2002. He has published 83 articles in journals as author/co-author, and also 43 abstracts presented in national and international meetings.

Area of Interest:

Molecular Sciences
100%
Biochemistry
62%
Calcium Signaling
90%
Microbiology
75%
Molecular Biology
55%

Research Publications in Numbers

Books
0
Chapters
3
Articles
156
Abstracts
5

Selected Publications

  1. Bollimuntha, S., S. Selvaraj and B.B. Singh, 2011. Emerging roles of canonical TRP channels in Neuronal function. Adv. Exper. Med. Biol., 704: 573-593.
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  2. Selvaraj, S., Y. Sun and B.B. Singh, 2010. TRPC channels and their implications for neurological diseases. CNS Neurolog. Disorders-Drug Targets, 9: 94-104.
    PubMed  |  Direct Link  |  
  3. Sahmoun, A.E. and B.B. Singh, 2010. Does a higher ratio of serum calcium to magnesium increase the risk for postmenopausal breast cancer. Med. Hypotheses, 75: 315-318.
    CrossRef  |  PubMed  |  Direct Link  |  
  4. Liu, X., H.L. Ong, B. Pani, K. Johnson, W.B. Swaim, B. Singh and I. Ambudkar, 2010. Effect of cell swelling on ER/PM junctional interactions and channel assembly involved in SOCE. Cell Calcium., 47: 491-499.
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  5. Labyed, Y., N. Kaabouch, R.R. Schultz, B.B. Singh and B. Milavetz, 2010. An improved 1-D gel electrophoresis image analysis system. Adv. Exper. Med. Biol., 680: 609-617.
    CrossRef  |  PubMed  |  Direct Link  |  
  6. Dasari, B., J.R.P. Prasanthi, G. Marwarha, B.B. Singh and O. Ghribi, 2010. The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells. BMC Ophthalmol., 10: 22-31.
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  7. Selvaraj, S., J.A. Watt and B.B. Singh, 2009. TRPC1 inhibits apoptotic cell degeneration induced by dopaminergic neurotoxin MPTP/MPP+. Cell Calcium, 46: 209-218.
    CrossRef  |  PubMed  |  Direct Link  |  
  8. Pani, B. and B.B. Singh, 2009. Lipid rafts/caveolae as microdomains of calcium signaling. Cell Calcium, 45: 625-633.
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  9. Pani, B., H.L. Ong, X. Liu, C. Rauser, I.S. Ambudkar and B.B Singh, 2008. Lipid rafts determine clustering of STIM1 in ER-plasma membrane junctions and regulation of store-operated Ca2+ entry (SOCE). J. Biol. Chem., 283: 17333-17340.
    CrossRef  |  PubMed  |  Direct Link  |  
  10. Pani, B. and B.B. Singh, 2008. Darier's disease: A calcium-signaling perspective. Cell. Mol. Life Sci., 65: 205-211.
    CrossRef  |  PubMed  |  Direct Link  |  
  11. Bandyopadhyay, B.C., H.L. Ong, T.P. Lockwich, X. Liu, B. Paria, B.B. Singh and I.S. Ambudkar, 2008. TRPC3 controls agonist-stimulated intracellular Ca2+ release by mediating the interaction between inositol 1,4,5-trisphosphate receptor and RACK1. J. Biolog. Chem., 283: 32821-32830.
    CrossRef  |  PubMed  |  Direct Link  |  
  12. Ong, H.L., X. Liu, K.T. Atanasova, B.B. Singh, B. Bandyopadhyay, W.D. Swaim, R.S. Hegde, A. Sherman and I.S. Ambudkar, 2007. Relocalization of STIM1 for activation of store-operated Ca2+ entry is determined by the depletion of subplasma membrane endoplasmic reticulum Ca2+ store. J. Biol. Chem., 282: 12176-12185.
    CrossRef  |  PubMed  |  Direct Link  |  
  13. Ong, H.L., K.T. Cheng, X. Liu, B. Bandyopadhyay and B.C. Paria et al., 2007. Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated Calcium influx: evidence for similarities in store-operated and calcium release-activated calcium channel components. J. Biolog. Chem., 282: 9105-9116.
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  14. Liu, X., O. Cheng, B.C. Bandyopadhyay, B. Pani, A. Dietrich, B. Paria, W. Swaim, L. Birnbaumer, B.B. Singh and I.S. Ambudkar, 2007. Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice. Proc. Natl. Acad. Sci. USA., 104: 17542-17547.
    CrossRef  |  PubMed  |  Direct Link  |  
  15. Labyed, Y., N. Kaabouch, R.R. Schultz and B.B. Singh, 2007. Automatic segmentation and band detection of protein images based on the standard deviation profile and its derivative. Proceedings of the International Conference on Electro/Information Technology, May 17-20, USA., pp: 577-582.
    CrossRef  |  Direct Link  |  
  16. Jara, J.H, B.B. Singh, A.M. Floden, J. Hansen and C.K. Combs, 2007. Tumor necrosis factor alpha stimulates NMDA receptor activity in mouse cortical neurons resulting in ERK-dependent death. J. Neurochemistry, 100: 1407-1420.
    CrossRef  |  PubMed  |  Direct Link  |  
  17. Pani, B., E. Cornatzer, W. Cornatzer, D.M. Shin, M.R. Pittelkow, I.S. Ambudkar and B.B. Singh, 2006. Up-regulation of Transient receptor potential canonical 1 (TRPC1) following Sarco(endo)plasmic reticulum Ca2+ ATPase 2 gene silencing promotes cell survival: a potential role for TRPC1 in Darier's disease. Mol. Biol. Cell, 17: 4446-4458.
    CrossRef  |  PubMed  |  Direct Link  |  
  18. Liu, X., B. Bandyopadhyay, T. Nakamoto, B.B. Singh, W. Liedtke, J.E. Melvin and I.S. Ambudkar, 2006. A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery. J. Biological Chem., 281: 15485-15495.
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  19. Bollimuntha, S., M. Ebadi and B.B. Singh, 2006. TRPC1 protects human SH-SY5Y cells against salsolinol-induced cytotoxicity by inhibiting apoptosis. Brain Res., 1099: 141-149.
    PubMed  |  
  20. Liu, X., B. Bandyopadhyay, B.B. Singh, K. Groschner and I.S. Ambudkar, 2005. Molecular analysis of a store-operated and 2-Acetyl-sn-glycerol-sensitive non-selective cation channel: Heteromeric assembly of TRPC1-TRPC3. J. Biological Chem., 280: 21600-21606.
    CrossRef  |  PubMed  |  Direct Link  |  
  21. Ebadi, M., H. Brown-Borg, H. El Refaey, B.B. Singh, S. Garrett, S. Shavali and S.K. Sharma, 2005. Metallothionein-mediated neuroprotection in genetically engineered mouse models of Parkinson's disease. Mol. Brain Res., 134: 67-75.
    CrossRef  |  PubMed  |  Direct Link  |  
  22. Bollimuntha, S., S. Shavali, S.K. Sharma, M. Ebadi and B.B Singh, 2005. TRPC1-mediated inhibition of 1-methyl-4-phenylpyridinium ion neurotoxicity in human SH-SY5Y neuroblastoma cells. J. Biological Chem., 280: 2132-2140.
    CrossRef  |  PubMed  |  Direct Link  |  
  23. Bollimuntha, S., E. Cornatzer and B.B. Singh, 2005. Plasma membrane localization and function of TRPC1 is dependent on its interaction with [beta]-tubulin in retinal epithelium cells. Visual Neuroscience, 22: 163-170.
    CrossRef  |  Direct Link  |  
  24. Itagaki, K., K.B. Kannan, B.B. Singh and C.J. Hauser, 2004. Cytoskeletal reorganization internalizes multiple Transient Receptor Potential channels and blocks calcium entry into human neutrophils. J. Immunol., 172: 601-607.
    PubMed  |  Direct Link  |  
  25. Ambudkar, I.S., S.C. Brazer, X. Liu, T. Lockwich and B.B. Singh, 2004. Plasma membrane localization of TRPC channels: Role of caveolar lipid rafts. Novartis Found. Symp., 258: 63-70.
    PubMed  |  Direct Link  |  
  26. Liu, X., B.B. Singh and I.S. Ambudkar, 2003. TRPC1 is required for functional store-operated Ca2+ Channels: role of acidic amino acid residues in the S5-S6 region. J. Biol. Chem., 278: 11337-11343.
    CrossRef  |  PubMed  |  Direct Link  |  
  27. Brazer, S.W., B.B. Singh, X. Liu, W. Swaim and I.S. Ambudkar, 2003. Caveolin-1 contributes to assembly of store-operated Ca2+ influx channels by regulating plasma membrane localization of TRPC1. J. Biological Chem., 278: 27208-27215.
    CrossRef  |  PubMed  |  Direct Link  |  
  28. Singh, B.B., X. Liu, J. Tang, M.X. Zhu and I.S. Ambudkar, 2002. Calmodulin regulates Ca2+-dependent feedback inhibition of store-operated Ca2+ influx by interaction with a site in the C terminus of TRPC1. Mol. Cell, 9: 739-750.
    CrossRef  |  PubMed  |  Direct Link  |  
  29. Yunfei, C., B.B. Singh, A. Aslanukov, H. Zhao and P.A. Ferreira, 2001. The docking of Kinesins, KIF5B and KIF5C, to ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain. J. Biol. Chem., 276: 41594-41602.
    CrossRef  |  PubMed  |  Direct Link  |  
  30. Singh, B.B., T. Lockwich, X. Liu and I.S. Ambudkar, 2001. Stabilization of cortical actin induces internalization of Transient receptor potential 3 (TRPC3)-associated caveolar Ca2+ signaling complex and loss of Ca2+ influx without disruption of TRP3-Inositol trisphosphate receptor association. J. Biol. Chem., 276: 42401-42408.
    CrossRef  |  PubMed  |  Direct Link  |  
  31. Singh, B.B., I. Curdt, D. Shomburg, P.S. Bisen and H. Bohme, 2001. Valine 77 of heterocystous ferredoxin FdxH2 in Anabaena variabilis strain ATCC 29413 is critical for its oxygen sensitivity. Mol. Cell. Biochem., 217: 137-142.
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  32. Singh, B.B., C. Zheng, X. Liu, T. Lockwich, D. Liao, M. Zhu, L. Birnbaumer and I.S. Ambudkar, 2001. TRP1-dependent enhancement of salivary gland fluid secretion: Role of store-operated calcium entry. FASEB J., 15: 1652-1654.
    CrossRef  |  PubMed  |  Direct Link  |  
  33. Singh, B.B., X. Liu and I.S. Ambudkar, 2000. Expression of truncated transient receptor potential protein 1α (Trp1α): evidence that the Trp1 C terminus modulates store-operated Ca2+ entry. J. Biol. Chem., 275: 36483-36486.
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