Dr. Gerald Y. Minuk
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Dr. Gerald Y. Minuk

Professor
University of Manitoba, Canada

Highest Degree
Ph.D. in Internal Medicine from University of Manitoba, Canada

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Area of Interest:

Biomedical Sciences
100%
Hepatocellular Carcinoma
62%
Viral Hepatitis
90%
Serology and Therapy
75%
Epidemiology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Wang, A., D. Yu, Y. Gong, J. Garber and G.Y. Minuk, 2017. Glycochenodeoxycholic acid does not increase transforming growth factor-beta expression in bile duct epithelial cells or collagen synthesis in myofibroblasts. J. Clin. Exp. Hepatol., 7: 316-320.
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  2. Pollock, G. and G.Y. Minuk, 2017. Diagnostic considerations for cholestatic liver disease. J. Gastroenterol. Hepatol., 32: 1303-1309.
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  3. Minuk, G.Y., G. Pollock and J. Uhanova, 2017. Adult idiopathic cholestasis: A condition more common in the Canadian Inuit? Int. J. Circumpolar Health, Vol. 76, No. 1. 10.1080/22423982.2017.1388104.
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  4. Labine, M., Y. Gong and G.Y. Minuk, 2017. Long-term, low-dose exposure to microcystin-LR does not cause or increase the severity of liver disease in rodents. Ann. Hepatol., 16: 959-965.
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  5. Ji, H., G.Y. Minuk, Z. Peng, Y. Chen, C. Pan and Y. Gong, 2017. Active immunization against transforming growth factor-beta1 prevents hepatic fibrosis in a rat model of liver disease. Can. J. Physiol. Pharmacol., 95: 743-749.
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  6. Huynh, C., G.Y. Minuk, J. Uhanova, M. Baikie, T. Wong and C. Osiowy, 2017. Serological and molecular epidemiological outcomes after two decades of universal infant Hepatitis B Virus (HBV) vaccination in Nunavut, Canada. Vaccine, 35: 4515-4522.
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  7. Bautista, W., J. Lipschitz, A. McKay and G.Y. Minuk, 2017. Cancer stem cells are depolarized relative to normal stem cells derived from human livers. Ann. Hepatol., 16: 297-303.
    PubMed  |  Direct Link  |  
  8. Xi, S., Y. Peng, G.Y. Minuk, M. Shi and B. Fu et al., 2016. The combination effects of Shen-Ling-Bai-Zhu on promoting apoptosis of transplanted H22 hepatocellular carcinoma in mice receiving chemotherapy. J. Ethnopharmacol., 190: 1-12.
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  9. Xi, S., M. Shi, X. Jiang, G.Y. Minuk and Y. Cheng et al., 2016. The effects of Tao-Hong-Si-Wu on hepatic necroinflammatory activity and fibrosis in a murine model of chronic liver disease. J. Ethnopharmacol., 180: 28-36.
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  10. Uhanova, J., G. Minuk, F. Lopez-Ficher and N. Chandok, 2016. Nonalcoholic fatty liver disease in Canadian first nations and non-first nations patients. Can. J. Gastroenterol. Hepatol. 10.1155/2016/6420408.
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  11. Minuk, G.Y., W. Bautista and J. Klein, 2016. Evidence of hepatitis B virus infection in cancer and noncancer stem cells associated with human hepatocellular carcinoma. Can. J. Infect. Dis. Med. Microbiol. 10.1155/2016/8931591.
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  12. Minuk, G.Y., J. Sanders, M. O'Brien and J. Uhanova, 2016. Estimated time from clinical presentation to the development of cirrhosis in non-cirrhotic adult patients with non-alcoholic fatty liver disease. Ann. Hepatol., 15: 944-945.
    PubMed  |  Direct Link  |  
  13. Minuk, G.Y. and Y. Baruch, 2016. Hepatitis B viral infection of hepatic progenitor cells. Resolving unresolved questions? Med. Hypotheses, 91: 24-27.
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  14. Wong, S.G., R. Pollock and G.Y. Minuk, 2015. Prevalence of liver disease and utilization of a hepatology consultation service at an urban tertiary care hospital. Clin. Invest. Med., 38: E358-E361.
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  15. Shi, X., X. Chi, Y. Pan, Y. Gao and W. Li et al., 2015. IL28B is associated with outcomes of chronic HBV infection. Yonsei Med. J., 56: 625-633.
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  16. Minuk, G.Y., G. Pollock, J. Lezen, V. Perez-Alvarez, F. Burczynski and J. Uhanova, 2015. The effects of steroid hormones on Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase (LCHAD) enzyme expression in LCHAD deficient cells and induction of long-chain fatty acid binding proteins on long-chain fatty acid-induced hepatotoxicity. J. Gastroenterol. Hepatol. Res., 4: 1768-1771.
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  17. Labine, M.A., C. Green, G. Mak, L. Xue, J. Nowatzki, J. Griffith and G.Y. Minuk, 2015. The geographic distribution of liver cancer in Canada does not associate with cyanobacterial toxin exposure. Int. J. Environ. Res. Public Health, 12: 15143-15153.
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  18. Labine, M. and G.Y. Minuk, 2015. Long-term, low-dose exposure to microcystin toxin does not increase the risk of liver tumor development or growth in mice. Hepatol. Res., 45: 683-692.
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  19. Yu, D., S. Holmes, J. Uhanova, J. Lipschitz, A. McKay and M.Y. Gerald, 2014. Predicting hepatocellular carcinoma recurrence and survival. Hepatogastroenterology, 61: 776-783.
    PubMed  |  
  20. Rempel, J.D., C. Krueger, G.Y. Minuk and S.G. Wong, 2014. Baseline comorbidities enhance the risk of treatment-induced depression in HCV-infected men: A pilot study. Am. J. Men's Health, 8: 427-433.
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  21. Mohajeri, S., O.B. Ijare, T. Bezabeh, S.B. King and M.A. Thomas et al., 2014. In vivo 1H MRS of human gallbladder bile at 3 T in one and two dimensions: Detection and quantification of major biliary lipids. NMR Biomed., 27: 1192-1202.
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  22. Minuk, G.Y., C. Huynh, J. Uhanova and C. Osiowy, 2014. Establishing diagnostic criteria for occult hepatitis B virus infections in community based populations. J. Med. Virol., 86: 156-161.
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  23. Minuk, G.Y., B. Lerner, S.B. Gibson, J.B. Johnston, J. Uhanova, A. Andonov and J. Wu, 2014. Hepatitis B and hepatitis C viral infections in patients with chronic lymphocytic leukemia. Can. J. Gastroenterol. Hepatol., 28: 131-134.
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  24. Kong, F., Y. Pan, X. Chi, X. Wang and L. Chen et al., 2014. Factors associated with spontaneous clearance of hepatitis C virus in Chinese population. BioMed Res. Int. 10.1155/2014/527030.
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  25. Zhang, M., R. Wu, J. Jiang, G.Y. Minuk and J. Niu, 2013. The presence of hepatitis B core antibody is associated with more advanced liver disease in alcoholic patients with cirrhosis. Alcohol, 47: 553-558.
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  26. Uhanova, J., R.B. Tate, D.J. Tataryn and G.Y. Minuk, 2013. The epidemiology of hepatitis C in a Canadian indigenous population. Can. J. Gastroenterol. Hepatol., 27: 336-340.
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  27. Minuk, G.Y., S. Macrury, J. Uhanova, S. Caouette and N. Coleman et al., 2013. A paucity of liver disease in Canadian Inuit with chronic hepatitis B virus, subgenotype B6 infection. J. Viral Hepatitis, 20: 890-896.
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  28. Minuk, G.Y., M. O'Brien, K. Hawkins, D. Emokpare and J. McHattie et al., 2013. Treatment of chronic hepatitis C in a Canadian Aboriginal population: Results from the PRAIRIE study. Can. J. Gastroenterol. Hepatol., 27: 707-710.
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  29. Kowalec, K., G.Y. Minuk, M.L. Borresen, A. Koch, B.J. McMahon, B. Simons and C. Osiowy, 2013. Genetic diversity of hepatitis B virus genotypes B6, D and F among circumpolar indigenous individuals. J. Viral Hepatitis, 20: 122-130.
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  30. Holmes, S., E.J. Griffith, G. Musto and G.Y. Minuk, 2013. Antihypertensive medications and survival in patients with cancer: A population-based retrospective cohort study. Cancer Epidemiol., 37: 881-885.
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  31. Bautista, W., V. Perez-Alvarez, F. Burczynski, A. Raouf, T. Klonisch and G. Minuk, 2013. Membrane potential differences and GABAA receptor expression in hepatic tumor and non-tumor stem cells. Can. J. Physiol. Pharmacol., 92: 85-91.
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  32. Uhanova, J., R.B. Tate, D.J. Tataryn and G.Y. Minuk, 2012. A Population-Based study of the epidemiology of hepatitis C in a North American population. J. Hepatol., 57: 736-742.
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  33. Minuk, G.Y., K. Kowalec, S. Caouette, B. Larke and C. Osiowy, 2012. The prevalence and long term outcome of occult hepatitis B virus infections in community based populations. J. Med. Virol., 84: 1369-1375.
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  34. Fan, J., H. Shen, Q. Dai, F.J. Burzynski, Y. Gong and G.Y. Minuk, 2012. Extent of extracellular Signal-Regulated kinases phosphorylation determines the sensitivity of hepatic stellate cells to staurosporine-induced apoptosis. J. Cent. S. Univ. Med. Sci., 37: 11-16.
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  35. Chandok, N., G. Minuk, M. Wengiel and J. Uhanova, 2012. Serum ferritin levels do not predict the stage of underlying Non-Alcoholic fatty liver disease. J. Gastrointestin. Liver. Dis., 21: 53-58.
    PubMed  |  Direct Link  |  
  36. Zhang, M., J. Uhanova and G.Y. Minuk, 2011. Liver transplant outcomes in a Canadian First Nations population. Can. J. Gastroenterol., 25: 307-310.
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  37. Schutt, V., J. Uhanova, C. Schneider, S. Menticoglou and C. Greenberget al 2011. Stable versus progressive hepatitis unique to pregnancy. Eur. J. Gastroenterol. Hepatol., 23: 171-176.
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  38. Minuk, G.Y., K. Hawkins, K.D. Kaita, S. Wong, E. Renner, L. Minuk and J. Uhanova, 2011. Daily ciprofloxacin treatment for patients with advanced liver disease awaiting liver transplantation reduces hospitalizations. Dig. Dis. Sci., 56: 1235-1241.
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  39. Lodewyks, C., J. Rodriguez, J. Yan, B. Lerner and J. Lipschitz et al 2011. GABA-B Receptor activation inhibits the in vitro migration of malignant hepatocytes. Can. J. Physiol. Pharmacol., 89: 393-400.
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  40. Krueger, C., K. Hawkins, S. Wong, M.W. Enns, G. Minuk and J.D. Rempel, 2011. Persistent pro-inflammatory cytokines following the initiation of pegylated IFN therapy in hepatitis C infection is associated with treatment-induced depression. J. Viral. Hepatol., 18: e284-e291.
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  41. McHutchison, J., Z. Goodman, K. Patel, H. Makhlouf and M. Rodriguez-Torres et al., 2010. Farglitazar lacks antifibrotic activity in patients with chronic hepatitis C infection. Gastroenterology, 138: 1365-1373.
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  42. Fournier, M.R., J. Klein, G.Y. Minuk and C.N. Bernstein, 2010. Changes in liver biochemistry during methotrexate use for inflammatory bowel disease. Am. J. Gastroenterol., 105: 1620-1626.
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  43. Chang, T.T., C.L. Lai, S.K. Yoon, S.S. Lee and S.H. Coelho et al., 2010. Entecavir treatment for up to 5 years in patients with hepatitis B e antigen-positive chronic hepatitis B. Hepatology, 51: 422-430.
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  44. Rempel, J.D., K.B. Aborsangaya, M.P. Alphonse and G.Y. Minuk, 2009. The influence of North American aboriginal ethnicity on pro‐inflammatory and anti‐inflammatory cytokine responses to IFN‐alpha. J. Viral Hepatitis, 16: 292-297.
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  45. Minuk, G.Y., R. Greenberg, J. Uhanova, K. Hawkins and W.D. Leslie, 2009. Bone mineral densities in individuals with Gilbert's syndrome: A cross-sectional, case-control pilot study. Can. J. Gastroenterol., 23: 431-436.
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  46. Marcellin, P., F. Bonino, G.K. Lau, P. Farci and C. Yurdaydin et al., 2009. Sustained response of hepatitis B e antigen-negative patients 3 years after treatment with peginterferon alfa-2a. Gastroenterology, 136: 2169-2179.
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  47. Labine, M.A. and G.Y. Minuk, 2009. Cyanobacterial toxins and liver disease. Can. J. Physiol. Pharmacol., 87: 773-788.
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  48. Fan, J., H. Shen, Q. Dai, G.Y. Minuk, F.J. Burzynski and Y. Gong, 2009. Bone morphogenetic protein-4 induced rat hepatic progenitor cell (WB-F344 cell) differentiation toward hepatocyte lineage. J. Cell. Physiol., 200: 72-81.
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  49. Zandieh, I., D. Krygier, V. Wong, J. Howard and L. Worobetz et al., 2008. The use of budesonide in the treatment of autoimmune hepatitis in Canada. Can. J. Gastroenterol. Hepatol., 22: 388-392.
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  50. Minuk, G.Y., S. Liu, K. Kaita, S. Wong, E. Renner, J. Rempel and J. Uhanova, 2008. Autoimmune hepatitis in a North American aboriginal/first nations population. Can. J. Gastroenterol. Hepatol., 22: 829-834.
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  51. Everson, G.T., L. Balart, S.S. Lee, R.W. Reindollar and M.L. Shiffman et al., 2008. Histological benefits of virological response to peginterferon alfa‐2a monotherapy in patients with hepatitis C and advanced fibrosis or compensated cirrhosis. Aliment. Pharmacol. Ther., 27: 542-551.
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  52. Becker, E.P., D. Sun and G.Y. Minuk, 2008. Exogenous adenosine 5'-triphosphate does not improve survival in rats with acute liver failure. Dig. Dis. Sci., 53: 794-798.
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  53. Watt, K., K. Kives, I. Corbin, M. Zhang and G.Y. Minuk, 2007. Lack of susceptibility to ischemic necrosis of the remnant liver following partial hepatectomy in the rat. Hepato Gastroenterol., 54: 463-465.
    PubMed  |  Direct Link  |  
  54. Singh, H., L. Targownik, G. Ward, G.Y. Minuk and C.N. Bernstein, 2007. An assessment of endoscopic and concomitant management of acute variceal bleeding at a tertiary care centre. Can. J. Gastroenterol., 21: 85-90.
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  55. Shen, H., J. Fan, F. Burczynski, G.Y. Minuk, P. Cattini and Y. Gong, 2007. Increased Smad1 expression and transcriptional activity enhances trans‐differentiation of hepatic stellate cells. J. cell. Physiol., 212: 764-770.
    CrossRef  |  Direct Link  |  
  56. Schutt, V.A. and G.Y. Minuk, 2007. Liver diseases unique to pregnancy. Best Pract. Res. Clin. Gastroenterol., 21: 771-792.
    CrossRef  |  Direct Link  |  
  57. Sakamoto, T., Y. Tanaka, J. Simonetti, C. Osiowy and M.L. Borresen et al., 2007. Classification of hepatitis B virus genotype B into 2 major types based on characterization of a novel subgenotype in arctic indigenous populations. J. Infect. Dis., 196: 1487-1492.
    CrossRef  |  Direct Link  |  
  58. Minuk, G.Y., M. Zhang, Y. Gong, L. Minuk and H. Dienes et al., 2007. Decreased hepatocyte membrane potential differences and GABAa-β3 expression in human hepatocellular carcinoma. Hepatology, 45: 735-745.
    CrossRef  |  Direct Link  |  
  59. Minuk, G.Y., A. Sun, D.F. Sun, J. Uhanova, L.E. Nicolle, B. Larke and A. Giulivi, 2007. Serological evidence of hepatitis E virus infection in an indigenous North American population. Can. J. Gastroenterol. Hepatol., 21: 439-442.
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  60. Chan, H.L., E.J. Heathcote, P. Marcellin, C.L. Lai and M. Cho et al., 2007. Treatment of hepatitis B e antigen-positive chronic hepatitis with telbivudine or adefovir: A randomized trial. Ann. Internal Med., 147: 745-754.
    Direct Link  |  
  61. Assy, N., P.C. Adams, P. Myers, V. Simon, G.Y. Minuk, W. Wall and C.N. Ghent, 2007. Randomized controlled trial of total immunosuppression withdrawal in liver transplant recipients: Role of ursodeoxycholic acid. Transplantation, 83: 1571-1576.
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  62. Assy, N., N. Pettigrew, S.S. Lee, R.K. Chaudhary, J. Johnston and G.Y. Minuk, 2007. Are chronic hepatitis C viral infections more benign in patients with hemophilia?. Am. J. Gastroenterol., 102: 1672-1676.
    CrossRef  |  Direct Link  |  
  63. Zhang, M., Y. Gong, I. Corbin and G.Y. Minuk, 2006. The effects of light and moderate-heavy ethanol exposure on the development of cirrhosis in rats. Dig. Dis. Sci., 51: 1732-1737.
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  64. Osiowy, C., E. Giles, Y. Tanaka, M. Mizokami and G.Y. Minuk, 2006. Molecular evolution of hepatitis B virus over 25 years. J. Virol., 80: 10307-10314.
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  65. Moser, M.J., Y. Gong, M.N. Zhang, J. Lipschitz, A. Cohen and G.Y. Minuk, 2006. Effects of colectomy on immediate-early protooncogene expression and hepatic regeneration in the rat. Dig. Dis. Sci., 51: 1179-1182.
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  66. Lai, C.L., D. Shouval, A.S. Lok, T.T. Chang and H. Cheinquer et al., 2006. Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B. N. Engl. J. Med., 354: 1011-1020.
  67. Chang, T.T., R.G. Gish, R. de Man, A. Gadano and J. Sollano et al., 2006. A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B. N. Engl. J. Med., 354: 1001-1010.
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  68. Woo, C.W.H., Y.L. Siow, G.N. Pierce, P.C. Choy, G.Y. Minuk, D. Mymin and O. Karmin, 2005. Hyperhomocysteinemia induces hepatic cholesterol biosynthesis and lipid accumulation via activation of transcription factors. Am. J. Physiol. Endocrinol. Metab., 288: E1002-E1010.
    CrossRef  |  
  69. Webster, J., J.Y. Jiang, B. Lu, F.Y. Xu and W.A. Taylor et al., 2005. On the mechanism of the increase in cardiolipin biosynthesis and resynthesis in hepatocytes during rat liver regeneration. Biochem. J., 386: 137-143.
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  70. Wang, G., Y. Gong, J. Anderson, D. Sun, G. Minuk, M.S. Roberts and F.J. Burczynski, 2005. Antioxidative function of L-FABP in L-FABP stably transfected chang liver cells. Hepatology, 42: 871-879.
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  71. Singh, H., R. Pollock, J. Uhanova, M. Kryger, K. Hawkins and G.Y. Minuk, 2005. Symptoms of obstructive sleep apnea in patients with nonalcoholic fatty liver disease. Dig. Dis. Sci., 50: 2338-2343.
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  72. Shen, H., M. Zhang, K. Kaita, G.Y. Minuk, J. Rempel and Y. Gong, 2005. Expression of Fc fragment receptors of immunoglobulin G (FcγRs) in rat hepatic stellate cells. J. Hepatol., 50: 181-187.
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  73. Minuk, G.Y., D.F. Sun, J. Uhanova, M. Zhang and S. Caouette et al., 2005. Occult hepatitis B virus infection in a community-based population. J. Hepatol., 42: 480-485.
  74. Minuk, G.Y., A.J. Cohen, N. Assy and M. Moser, 2005. Viral hepatitis and the surgeon. HPB Surg., 7: 56-64.
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  75. Minuk, G.Y., A. Gutkin, S.G. Wong and K.D.E. Kaita, 2005. Patient concerns regarding chronic hepatitis C infections. J. Viral Hepatitis, 12: 51-57.
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  76. Ji, H., H. Shen, J. Uhanova, M. Zhang, G.Y. Minuk and Y. Gong, 2005. Effects of sildenafil citrate on hepatic function and regeneration in normal and alcohol-fed rats. Liver Int., 25: 913-919.
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  77. Watt, K., K. Hawkins, M. Zhang, J. Lipschitz and G. Sandha et al., 2004. Transforming growth beta (TGF-β) protein levels are not elevated in the blood or bile of patients with primary sclerosing cholangitis. Digest. Dis. Sci., 49: 5-8.
  78. Watt, K., J. Uhanova, Y. Gong, K. Kaita, K. Doucette, N. Pettigrew and G.Y. Minuk, 2004. Serum immunoglobulins predict the extent of hepatic fibrosis in patients with chronic hepatitis C virus infection. J. Viral Hepatitis, 11: 251-256.
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  79. Wang, G.Q., Q.M. Chen, G.Y. Minuk, Y. Gong and F.J. Burczynski, 2004. Enhanced expression of cytosolic fatty acid binding protein and fatty acid uptake during liver regeneration in rats. Mol. Cell. Biochem., 262: 41-49.
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  80. Qi, K., H. Qiu, D. Sun, G.Y. Minuk, M. Lizardo, J. Rutherford and F.W. Orr, 2004. Impact of cirrhosis on the development of experimental hepatic metastases by B16F1 melanoma cells in C57BL/6 mice. Hepatology, 40: 1144-1150.
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  81. Pockros, P.J., R. Carithers, P. Desmond, D. Dhumeaux and M.W. Fried et al., 2004. Efficacy and safety of two-dose regimens of peginterferon alpha-2a compared with interferon alpha-2a in chronic hepatitis C: A multicenter, randomized controlled trial. Am. J. Gastroenterol., 99: 1298-1305.
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  82. Nicolle, L.E., A. Gutkin, G. Smart, M. Dawood and M. Drebot et al., 2004. Serological studies of West Nile virus in a liver transplant population. Can. J. Infect. Dis. Med. Microbiol., 15: 271-274.
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  83. Minuk, G.Y., J. Rempel, P. Wong, M. Zhang and S. Wong et al., 2004. Rebound hepatitis following withdrawal of immunosuppressive therapy in patients with chronic hepatitis B viral infections. Hepatol. Res., 30: 4-10.
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  84. Minuk, G.Y., D.F. Sun, R. Greenberg, M. Zhang and K. Hawkins et al., 2004. Occult hepatitis B virus infection in a North American adult hemodialysis patient population. Hepatology, 40: 1072-1077.
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  85. Corbin, I.R., L. Ryner, H. Singh and G.Y. Minuk, 2004. Quantitative hepatic phosphorus-31 magnetic resonance spectroscopy in compensated and decompensated cirrhosis. Am. J. Physiol., 287: G379-G384.
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  86. Zhang, M., J. Uhanova, I. Corbin, C. Bernstein and G.Y. Minuk, 2003. Effects of daily, light and moderate-heavy ethanol exposure on extent of hepatic injury and recovery following toxin-induced acute hepatitis in rats. Dig. Dis. Sci., 48: 926-931.
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  87. Wong, F., A.T. Blei, L.M. Blendis and P.J. Thuluvath, 2003. A vasopressin receptor antagonist (VPA-985) improves serum sodium concentration in patients with hyponatremia: A multicenter, randomized, placebo‐controlled trial. Hepatology, 37: 182-191.
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  88. Sun, D., Y. Gong, H. Kojima, G. Wang, E. Ravinsky, M. Zhang and G.Y. Minuk, 2003. Increasing cell membrane potential and GABAergic activity inhibits malignant hepatocyte growth. Am. J. Physiol.-Gastrointest. Liver Physiol., 285: G12-G19.
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  89. Shen, H., G. Huang, M. Hadi, P. Choy and M. Zhang et al., 2003. Transforming growth factor beta1 down-regulation of Smad1 gene expression in rat hepatic stellate cells. Am. J. Physiol. Gastrointest Liver Physiol., 285: G539-G546.
  90. Minuk, G.Y., M. Zhang, S.G.M. Wong, J. Uhanova and C.N. Bernstein et al., 2003. Viral hepatitis in a Canadian first nations community. Can. J. Gastroenterol., 17: 593-596.
    CrossRef  |  
  91. Minuk, G.Y., C. Osiowy, Y. Gong and M. Zhang, 2003. HBV-mutant detection by melting curve analysis. Hepatology, 37: 479-480.
  92. Minuk, G.Y. and J. Uhanova, 2003. Viral hepatitis in the Canadian Inuit and first nations populations. Can. J. Gastroenterol., 17: 707-712.
    CrossRef  |  
  93. Kojima, H., K.D.E. Kaita, Z. Xu, J.H. Ou, Y. Gong, M. Zhang and G.Y. Minuk, 2003. The absence of up-regulation of telomerase activity during regeneration after partial hepatectomy in hepatitis B virus X gene transgenic mice. J. Hepatol., 39: 262-268.
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  94. Kojima, H., K.D.E. Kaita, M. Zhang, A. Giulivi and G.Y. Minuk, 2003. Genomic analysis of a recently identified virus (SEN virus) and genotypes D and H by polymerase chain reaction. Antiviral Res., 60: 27-33.
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  95. Ji, H., J.Y. Jiang, Z. Xu, E.A. Kroeger and S.S. Lee et al., 2003. Change in lipid profile and impairment of endothelium-dependent relaxation of blood vessels in rats after bile duct ligation. Life Sci., 73: 1253-1263.
    CrossRef  |  Direct Link  |  
  96. Hogg, R.S., K.J. Craib, D. Pi, S.S. Lee and G.Y. Minuk et al., 2003. Health and socioeconomic status differences among antibody hepatitis C positive and negative transfusion recipients, 1986-1990. Can. J. Public Health, 94: 130-134.
    Direct Link  |  
  97. Corbin, I.R., R. Buist, J. Peeling, M. Zhang, J. Uhanova and G.Y. Minuk, 2003. Utility of hepatic phosphorus-31 magnetic resonance spectroscopy in a rat model of acute liver failure. J. Invest. Med., 51: 42-49.
    CrossRef  |  Direct Link  |  
  98. Corbin, I.R., R. Buist, J. Peeling, M. Zhang, J. Uhanova and G.Y. Minuk, 2003. Hepatic 31P MRS in rat models of chronic liver disease: Assessing the extent and progression of disease. Gut, 52: 1046-1053.
    CrossRef  |  Direct Link  |  
  99. Corbin, I.R. and G.Y. Minuk, 2003. Serial percutaneous liver biopsies in laboratory rats. Dig. Dis. Sci., 48: 1939-1943.
    CrossRef  |  
  100. Zhang, M., Y. Gong, C. Osiowy and G.Y. Minuk, 2002. Rapid detection of hepatitis B virus mutations using real‐time PCR and melting curve analysis. Hepatology, 36: 723-728.
    CrossRef  |  Direct Link  |  
  101. Wong, S.G., D. Primi, H. Kojima, A. Sottini and A. Giulivi et al., 2002. Insights into SEN virus prevalence, transmission and treatment in community-based persons and patients with liver disease referred to a liver disease unit. Clin. Infect. Dis., 35: 789-795.
    CrossRef  |  Direct Link  |  
  102. Watt, K., J. Uhanova and G.Y. Minuk, 2002. Hepatorenal syndrome: Diagnostic accuracy, clinical features and outcome in a tertiary care center. Am. J. Gastroenterol., 97: 2046-2050.
    CrossRef  |  Direct Link  |  
  103. Shen, H., M. Zhang, G.Y. Minuk and Y. Gong, 2002. Different effects of rat interferon alpha, beta and gamma on rat hepatic stellate cell proliferation and activation. BMC Cell Biol., Vol. 3. 10.1186/1471-2121-3-9.
    CrossRef  |  Direct Link  |  
  104. Moses, S., K. Mestery, K.D.E. Kaita and G.Y. Minuk, 2002. Viral hepatitis in a Canadian street-involved population. Can. J. Public Health, 93: 123-128.
    Direct Link  |  
  105. Minuk, G.Y., 2002. Hepatitis B viral mutants and their relevance to the Canadian health care system. Can. J. Gastroenterol., 16: 45-54.
    CrossRef  |  Direct Link  |  
  106. Meyers, A.F.A., Y. Gong, M. Zhang, O.G. Casiro, S. Battistuzzi, N. Pettigrew and G.Y. Minuk, 2002. Liver development in a rat model of fetal alcohol syndrome. Dig. Dis. Sci., 47: 767-772.
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  107. Kojima, H., K.D.E. Kaita, K. Hawkins, J. Uhanova and G.Y. Minuk, 2002. Use of fluoroquinolones in patients with chronic hepatitis C virus-induced liver failure. Antimicrob. Agents Chemother., 46: 3280-3282.
    CrossRef  |  Direct Link  |  
  108. Gong, Y., S. Deng, M. Zhang, G. Wang, G.Y. Minuk and F. Burczynski, 2002. A cyclin-dependent kinase inhibitor (p21/WAF1/CIP1) affect thymidine incorporation in human cancer cells. BJC., 86: 625-629.
  109. Corbin, I.R., Y. Gong, M. Zhang and G.Y. Minuk, 2002. Proliferative and nutritional dependent regulation of glyceraldehyde‐3‐phosphate dehydrogenase expression in the rat liver. Cell Prolif., 35: 173-182.
    CrossRef  |  Direct Link  |  
  110. Corbin, I.R., R. Buist, V. Volotovskyy, J. Peeling, M. Zhang and G.Y. Minuk, 2002. Regenerative activity and liver function following partial hepatectomy in the rat using 31P‐MR spectroscopy. Hepatology, 36: 345-353.
    CrossRef  |  Direct Link  |  
  111. Zdanuk, S., J. Gimpel, J. Uhanova, K.D.E. Kaita and G.Y. Minuk, 2001. The impact of medical informatics on the confidence of rural physicians caring for patients with chronic hepatitis C viral infections. Family Pract., 18: 602-604.
    CrossRef  |  Direct Link  |  
  112. Schoen, J.M., H.H. Wang, G.Y. Minuk and W.W. Lautt, 2001. Shear stress-induced nitric oxide release triggers the liver regeneration cascade. Nitric Oxide, 5: 453-464.
    CrossRef  |  Direct Link  |  
  113. Moser, M.J., Y. Gong, M.N. Zhang, J. Johnston, J. Lipschitz and G.Y. Minuk, 2001. Immediate-early protooncogene expression and liver function following various extents of partial hepatectomy in the rat. Dig. Dis. Sci., 46: 907-914.
    CrossRef  |  Direct Link  |  
  114. Minuk, G.Y. and J. Uhanova, 2001. Hepatitis B infection in Canada. Can. J. Infect. Dis., 12: 351-356.
  115. Harding, G., R. McKenna and G. Minuk, 2001. The immune response to alkaline phosphatase and other immunogens in patients with primary biliary cirrhosis. Hepato-Gastroenterology, 48: 66-70.
    PubMed  |  
  116. Gong, Y., M. Zhang, L. Cui and G.Y. Minuk, 2001. Sequence and chromosomal assignment of a human novel cDNA: Similarity to gamma-aminobutyric acid transporter. Can. J. Physiol. Pharmacol., 79: 977-984.
    CrossRef  |  Direct Link  |  
  117. Zhang, M.N., Y. Gong and G.Y. Minuk, 2000. The effects of acute ethanol exposure on inhibitors of hepatic regenerative activity in the rat. Mol. Cell. Biochem., 207: 109-114.
    CrossRef  |  Direct Link  |  
  118. Zhang, M., Y. Gong, N. Assy and G.Y. Minuk, 2000. Increased GABAergic activity inhibits α-fetoprotein mRNA expression and the proliferative activity of the HepG2 human hepatocellular carcinoma cell line. J. Hepatol., 32: 85-91.
    CrossRef  |  Direct Link  |  
  119. Zhang, M., Y. Gong, I. Corbin, A. Mellon, P. Choy, J. Uhanova and G.Y. Minuk, 2000. Light ethanol consumption enhances liver regeneration after partial hepatectomy in rats. Gastroenterology, 119: 1333-1339.
    CrossRef  |  Direct Link  |  
  120. Moser, M.A.J., N.M. Kneteman and G.Y. Minuk, 2000. Research toward safer resection of the cirrhotic liver. HPB Surg., 11: 285-297.
    CrossRef  |  Direct Link  |  
  121. Moser, M., M. Zhang, Y. Gong, J. Johnson, N. Kneteman and G.Y. Minuk, 2000. Effect of preoperative interventions on outcome following liver resection in a rat model of cirrhosis. J. Hepatol., 32: 287-292.
    CrossRef  |  Direct Link  |  
  122. Minuk, G.Y., S. Weinstein and K.D. Kaita, 2000. Serum cholesterol and low-density lipoprotein cholesterol levels as predictors of response to interferon therapy for chronic hepatitis C. Ann. Inter. Med., 132: 761-762.
    PubMed  |  Direct Link  |  
  123. Minuk, G.Y., P.S. Orr, R. Brown, S. Macdonald, R.K. Chaudhary and P. Temple, 2000. Pre-core mutant infections in the Canadian Inuit. J. Hepatol., 33: 781-784.
    CrossRef  |  Direct Link  |  
  124. Minuk, G.Y., J. Uhanova and K.D. Kaita, 2000. The prevalence of intrinsic host risk factors associated with progressive disease in patients with chronic hepatitis C viral infections. Can. J. Public Health, 91: 171-175.
    PubMed  |  Direct Link  |  
  125. Minuk, G.Y., 2000. GABA and hepatocellular carcinoma. Mol. Cell. Biochem., 207: 105-108.
    CrossRef  |  Direct Link  |  
  126. Gong, Y., L. Cui and G.Y. Minuk, 2000. The expression of insulin-like growth factor binding proteins in human hepatocellular carcinoma. Mol. Cell. Biochem., 207: 101-104.
    CrossRef  |  Direct Link  |  
  127. Fallows, G., K. Kaita, G. Minuk, F. Penner, G. Smart, M. Dawood and B. Rosser, 2000. Early changes in Hepatitis C Virus (HCV) RNA levels predict response to interferon treatment in non-cirrhotic HCV patients. Can. J. Gastroenterol. Hepatol., 14: 30B-35B.
    CrossRef  |  Direct Link  |  
  128. Erlitzki, R., Y. Gong, M. Zhang and G. Minuk, 2000. Identification of γ-aminobutyric acid receptor subunit types in human and rat liver. Am. J. Physiol.-Gastrointest. Liver Physiol., 279: G733-G739.
    CrossRef  |  Direct Link  |  
  129. Collier, J.D., P.A. Adams, V. Feinman, C. Ghent and H. Witt-Sullivan et al., 2000. Long term follow-up of patients with chronic hepatitis C treated with alpha interferon. Can. J. Gastroenterol. Hepatol., 14: 77B-81B.
    CrossRef  |  Direct Link  |  
  130. Cohen, A.J., F.J. Burczynski, B.G. Rosser, J. Lipschitz and G.Y. Minuk, 2000. The effects of various organ preservation solutions on hepatocyte membrane potentials, intracellular calcium concentrations and outcome following liver transplantation. Am. J. Surg., 179: 154-160.
    CrossRef  |  Direct Link  |  
  131. Assy, N., K. Kaita, D. Mymin, C. Levy, B. Rosser and G. Minuk, 2000. Fatty infiltration of liver in hyperlipidemic patients. Dig. Dis. Sci., 45: 1929-1934.
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  132. Assy, N. and G.Y. Minuk, 2000. Serum aspartate but not alanine aminotransferase levels help to predict the histological features of chronic hepatitis C viral infections in adults. Am. J. Gastroenterol., 95: 1545-1550.
    CrossRef  |  Direct Link  |  
  133. Abosh, D., B. Rosser, K. Kaita, R. Bazylewski and G. Minuk, 2000. Outcomes following liver transplantation for patients with alcohol-versus nonalcohol-induced liver disease. Can. J. Gastroenterol. Hepatol., 14: 851-855.
    CrossRef  |  Direct Link  |  
  134. Pockros, P.J., V.G. Bain, E.B. Hunter, A. Conrad and A. Balart et al., 1999. A comparison of reverse transcription–polymerase chain reaction and branched‐chain DNA assays for hepatitis C virus RNA in patients receiving interferon treatment. J. Viral Hepatitis, 6: 145-150.
    CrossRef  |  Direct Link  |  
  135. Minuk, G.Y., 1999. The influence of host factors on the natural history of chronic hepatitis C viral infections. J. Viral Hepatitis, 6: 271-276.
    CrossRef  |  Direct Link  |  
  136. Minuk, G.Y., 1999. Principles in the management of chronic hepatitis B viral infection. Can. J. Gastroenterol. Hepatol., 13: 75-77.
    CrossRef  |  Direct Link  |  
  137. Lou, G., M. Zhang and G.Y. Minuk, 1999. Effects of acute ethanol exposure on polyamine and gamma-aminobutyric acid metabolism in the regenerating liver. Alcohol, 19: 219-227.
    CrossRef  |  Direct Link  |  
  138. Heathcote, J., J. McHutchison, S. Lee, M. Tong and K. Benner et al., 1999. A pilot study of the CY‐1899 T‐cell vaccine in subjects chronically infected with hepatitis B virus. Hepatology, 30: 531-536.
    CrossRef  |  Direct Link  |  
  139. Gong, Y., M. Zhang and G.Y. Minuk, 1999. Regulation of transforming growth factor-β1 gene expression and cell proliferation in human hepatocellular carcinoma cells (PLC/PRF/5) by tamoxifen. J. Laboratory Clin. Med., 134: 90-95.
    CrossRef  |  Direct Link  |  
  140. Gong, Y., L. Cui and G.Y. Minuk, 1999. Effects of acute and chronic ethanol exposure on the hepatic gamma-aminobutyric acid transport system in rats. Alcohol, 19: 213-218.
    CrossRef  |  Direct Link  |  
  141. Everson, G.T., D.M. Jensen, J.R. Craig, D.J. van Leeuwen and V.G. Bain et al., 1999. Efficacy of interferon treatment for patients with chronic hepatitis C: Comparison of response in cirrhotics, fibrotics, or nonfibrotics. Hepatology, 30: 271-276.
    CrossRef  |  Direct Link  |  
  142. Erlitzki, R. and G.Y. Minuk, 1999. Telomeres, telomerase and HCC: The long and the short of it. J. Hepatol., 31: 939-945.
  143. Burczynski, F.J., G. Wang, G.Y. Minuk and B. Rosser, 1999. Altered transmembrane ionic flux in hepatocytes isolated from cirrhotic rats. J. Hepatol., 30: 492-497.
    CrossRef  |  Direct Link  |  
  144. Bonkovsky, H.L. and J.M. Woolley, 1999. Reduction of health‐related quality of life in chronic hepatitis C and improvement with interferon therapy. Hepatology, 29: 264-270.
    CrossRef  |  Direct Link  |  
  145. Assy, N., Y.W. Gong, M. Zhang and G.Y. Minuk, 1999. Appearance of an inhibitory cell nuclear antigen in rat and human serum during variable degrees of hepatic regenerative activity. World J. Gastroenterol., 5: 103-106.
    CrossRef  |  Direct Link  |  
  146. Assy, N., B.G. Rosser, G.R. Grahame and G.Y. Minuk, 1999. Risk of sedation for upper GI endoscopy exacerbating subclinical hepatic encephalopathy in patients with cirrhosis. Gastrointestinal Endoscopy, 49: 690-694.
    CrossRef  |  Direct Link  |  
  147. Assy, N. and G.Y. Minuk, 1999. A comparison between previous and present histologic assessments of chronic hepatitis C viral infections in humans. World J. Gastroenterol., 5: 107-110.
    CrossRef  |  Direct Link  |  
  148. Zhang, M., Y.W. Gong and G.Y. Minuk, 1998. The effects of ethanol and gamma aminobutyric acid alone and in combination on hepatic regenerative activity in the rat. J. Hepatol., 29: 638-641.
    CrossRef  |  Direct Link  |  
  149. Poynard, T., P. Marcellin, S.S. Lee, C. Niederau and G.S. Minuk et al., 1998. Randomised trial of interferon α2b plus ribavirin for 48 weeks or for 24 weeks versus interferon α2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. Lancet, 352: 1426-1432.
    CrossRef  |  Direct Link  |  
  150. Pockros, P.J., M. Tong, W.M. Lee, D.J. Van Leeuwen and E.B. Keeffe et al., 1998. Relationship between biochemical and virological responses to interferon therapy in chronic hepatitis C infection. J. Viral Hepatitis, 5: 271-276.
    CrossRef  |  Direct Link  |  
  151. Minuk, G.Y., A.F. Meyers, D.J. Legare, P. Sadri and W.W. Lautt, 1998. Fetal exposure to alcohol results in adult insulin resistance in the rat. Proc. Western Pharmacol. Soc., 41: 39-40.
  152. Minuk, G.Y., 1998. Canadian association of gastroenterology practice guidelines: Evaluation of abnormal liver enzyme tests. Can. J. Gastroenterol. Hepatol., 12: 417-421.
    PubMed  |  Direct Link  |  
  153. Lee, W.M., K.R. Reddy, M.J. Tong, M. Black and D.J. Van Leeuwen et al., 1998. Early hepatitis C virus-RNA responses predict interferon treatment outcomes in chronic hepatitis C. Hepatology, 28: 1411-1415.
    CrossRef  |  Direct Link  |  
  154. Kaita, K.D.E., D. Roberts, B. Rosser and G.Y. Minuk, 1998. An institutional review of fulminant hepatic failure in an urban Canadian centre. Hepatol. Res., 11: 115-124.
    CrossRef  |  Direct Link  |  
  155. Heathcote, E.J., E.B. Keeffe, S.S. Lee, S.V. Feinman and M.J. Tong et al., 1998. Re‐treatment of chronic hepatitis C with consensus interferon. Hepatology, 27: 1136-1143.
    CrossRef  |  Direct Link  |  
  156. Farrell, G.C., B.R. Bacon and R.D. Goldin, 1998. Lymphoblastoid interferon alfa‐n1 improves the long‐term response to a 6‐month course of treatment in chronic hepatitis C compared with recombinant interferon alfa‐2b: Results of an international randomized controlled trial. Hepatology, 27: 1121-1127.
    CrossRef  |  Direct Link  |  
  157. Davis, G.L., R. Esteban-Mur, V. Rustgi, J. Hoefs and S.C. Gordon et al., 1998. Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C. N. Engl. J. Med., 339: 1493-1499.
    CrossRef  |  Direct Link  |  
  158. Assy, N., Y. Gong, M. Zhang, N.M. Pettigrew, D. Pashniak and G.Y. Minuk, 1998. Use of proliferating cell nuclear antigen as a marker of liver regeneration after partial hepatectomy in rats. J. Lab. Clin. Med., 131: 251-256.
    CrossRef  |  Direct Link  |  
  159. Tong, M.J., K.R. Reddy, W.M. Lee, P.J. Pockros and J.C. Hoefs et al., 1997. Treatment of chronic hepatitis C with consensus interferon: A multicenter, randomized, controlled trial. Hepatology, 26: 747-754.
    CrossRef  |  Direct Link  |  
  160. Minuk, G.Y., N. Assy, L.X. Ding, T. Gauthier and D.D. Pashniak, 1997. Effect of quinolone antibiotics on hepatic growth and protein synthesis following partial hepatectomy in rats. J. Gastroenterol. Hepatol., 12: 54-57.
    CrossRef  |  Direct Link  |  
  161. Minuk, G.Y., B.T. Kren, R. Xu, X. Zhang and F. Burczynski et al., 1997. The effect of changes in hepatocyte membrane potential on immediate‐early proto‐oncogene expression following partial hepatectomy in rats. Hepatology, 25: 1123-1127.
    CrossRef  |  Direct Link  |  
  162. Minuk, G.Y., 1997. Mechanisms and management of hepatic fibrosis. Chin. J. Gastroenterol., 2: 250-252.
  163. Kaita, K.D.E., N. Pettigrew and G.Y. Minuk, 1997. Hepatic regeneration in humans with various liver disease as assessed by Ki‐67 staining of formalin‐fixed paraffin‐embedded liver tissue. Liver Int., 17: 13-16.
    CrossRef  |  Direct Link  |  
  164. Bazylewski, R., B.G. Rosser, A. Cohen, K.D.E. Kaita and G.Y. Minuk, 1997. Profile of a liver transplant follow-up clinic in a nontransplant Canadian urban centre. Can. J. Gastroenterol. Hepatol., 11: 235-238.
    CrossRef  |  Direct Link  |  
  165. Assy, N. and G.Y. Minuk, 1997. Liver regeneration: Methods for monitoring and their applications. J. Hepatol., 26: 945-952.
    CrossRef  |  Direct Link  |  
  166. Zhang, X.K., T. Gauthier, F.J. Burczynski, G.Q. Wang, Y. Gong and G.Y. Minuk, 1996. Changes in liver membrane potentials after partial hepatectomy in rats. Hepatology, 23: 549-551.
    CrossRef  |  Direct Link  |  
  167. Zhang, M., G. Song and G.Y. Minuk, 1996. Effects of hepatic stimulator substance, herbal medicine, selenium/vitamin E and ciprofloxacin on cirrhosis in the rat. Gastroenterology, 110: 1150-1155.
    CrossRef  |  PubMed  |  Direct Link  |  
  168. Wong, S., K. Kaita, T. Gauthier, S. Jones and G.Y. Minuk, 1996. A comparative trial of recombinant interferon alpha 2A versus alpha 2 beta on myelosuppression in healthy adult volunteers. Hepato-Gastroenterology, 43: 301-305.
    Direct Link  |  
  169. Wong, S., A.E. Mehta, C. Faiman, L. Berard, T. Ibbott and G.Y. Minuk, 1996. Absence of serologic evidence for hepatitis C virus infection in patients with Hashimoto's thyroiditis. Hepato-Gastroenterology, 43: 420-421.
    Direct Link  |  
  170. Kobrinsky, N.L., D. Hartfield, H. Horner, A. Maksymiuk, G.Y. Minuk, D.F. White and T.J. Feldstein, 1996. Treatment of advanced malignancies with high-dose acetaminophen and N-acetylcysteine rescue. Cancer Invest., 14: 202-210.
    CrossRef  |  Direct Link  |  
  171. Kilmurry, M.R., E.J. Heathcote, K. Cauch-Dudek, K. O'Rourke and R.J. Bailey et al., 1996. Is the Mayo model for predicting survival useful after the introduction of ursodeoxycholic acid treatment for primary biliary cirrhosis? Hepatology, 23: 1148-1153.
    CrossRef  |  Direct Link  |  
  172. Janzen, L., G.Y. Minuk, M. Fast and K.N. Bernstein, 1996. Vaccine-induced hepatitis B surface antigen positivity in adult hemodialysis patients: Incidental and surveillance data. J. Am. Soc. Nephrol., 7: 1228-1234.
    Direct Link  |  
  173. Gong, Y., L. Cui and G.Y. Minuk, 1996. Comparison of glyceraldehyde‐3‐phosphate dehydrogenase and 28S‐ribosomal RNA gene expression in human hepatocellular carcinoma. Hepatology, 23: 734-737.
    CrossRef  |  Direct Link  |  
  174. Chrusch, C. and G.Y. Minuk, 1996. Public knowledge about hepatitis-B related issues in Korea. Can. J. Infect Dis., 7: 53-55.
    CrossRef  |  Direct Link  |  
  175. Byron, D. and G.Y. Minuk, 1996. Clinical hepatology: Profile of an urban, hospital‐based practic. Hepatology, 24: 813-815.
    CrossRef  |  Direct Link  |  
  176. Assy, N. and G.Y. Minuk, 1996. Liver disease in pregnancy. J. Am. Coll. Surg., 183: 643-653.
    PubMed  |  Direct Link  |  
  177. Wong, S., T. Gauthier, K.D.E. Kaita and G.Y. Minuk, 1995. The differential effects of three forms of interferon alpha on hepatic regeneration following partial hepatectomy in the rat. Hepatology, 22: 883-886.
  178. Minuk, G.Y., W.W.S. Wong and K.D.E. Kaita, 1995. Risk factors for hepatitis C virus infection in Canadian patients with chronic type C hepatitis. Can. J. Gastroenterol., 9: 137-140.
    CrossRef  |  
  179. Minuk, G.Y., T. Gauthier, X.K. Zhang, G.Q. Wang, N.M. Pettigrew and F.J. Burczynski, 1995. Ciprofloxacin prevents the inhibitory effects of acute ethanol exposure on hepatic regeneration in the rat. Hepatology, 22: 1797-1800.
    CrossRef  |  
  180. Minuk, G.Y., K. Kaita, T. Gauthier, T. Dembinski and L.J. Murphy, 1995. Effect of exogenous γ-Aminobutyric Acid (GABA) on hepatic Insulin-like Growth Factor I (IGF-I) and IGF-I binding protein (IGFBP-I) mRNA abundance following partial hepatectomy in rats. Can. J. Physiol. Pharmacol., 73: 1546-1551.
    CrossRef  |  Direct Link  |  
  181. Minuk, G.Y., G.E. Rockman, G.B. German, D.R. Duerksen, G. Borrett and L. Hoeschen, 1995. The use of sodium valproate in the treatment of alcoholism. J. Addict. Dis., 14: 67-74.
    CrossRef  |  
  182. Minuk, G.Y. and P. Gray, 1995. Fulminant Hepatic Failure. In: Consultations in Gastroenterology, Snape, Jr. W.J. (Ed.). W.B. Saunders Co., Philadelphia, PA., USA., pp: 675-690.
  183. Blajchman, M.A., S.B. Bull, S.V. Feinman, R. Herst and Canadian Post-Transfusion Hepatitis Prevention Study Group, 1995. Post-transfusion hepatitis: Impact of non-A, non-B hepatitis surrogate tests. Lancet, 345: 21-25.
    CrossRef  |  
  184. Wong, W.W.S. and G.Y. Minuk, 1994. A cross-sectional seroepidemiologic survey of chronic hepatitis B virus infections in Southeast Asian immigrants residing in a Canadian urban centre. Clin. Invest. Med., 17: 443-447.
    Direct Link  |  
  185. Minuk, G.Y., L.X. Ding, C. Hannon and L. Sekla, 1994. The risks of transmission of acute hepatitis A and B virus infection in an urban centre. J. Hepatol., 21: 118-121.
    CrossRef  |  
  186. Minuk, G.Y., G.B. German, K. Bernstein, A. Fine, M. Schroeder and W.W.S. Wong, 1994. Failure of passively administered antibody to hepatitis B surface antigen to augment the immune response to a low responder population to hepatitis B vaccination. Clin. Invest. Med., 17: 61-65.
  187. Minuk, G.Y., D. Yu, W. Smith, P. Orr and T. Gauthier et al., 1994. Putrescine levels in the staple foods of the Canadian Inuit and Hong Kong Chinese: A possible explanation for discrepant hepatocellular carcinoma rates in the two populations. Arctic Med. Res., 53: 296-297.
  188. Kroeker, S. and G.Y. Minuk, 1994. Intentional iron overdose: An institutional review. Can. Med. Assoc. J., 150: 45-48.
    Direct Link  |  
  189. Heathcote, E.J., K. Cauch-Dudek, V. Walker, R.J. Bailey and L.M. Blendis et al., 1994. The canadian multicenter double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis. Hepatology, 19: 1149-1156.
    CrossRef  |  
  190. Simons, F.E.R., W.T.A. Watson, G.Y. Minuk and K.J. Simons, 1993. Cetirizine pharmacokinetics and pharmacodynamics in primary biliary cirrhosis. J. Clin. Pharmacol., 33: 949-954.
    CrossRef  |  
  191. Peeling, J., L. Shoemaker, T. Gauthier, A. Benarroch, G.R. Sutherland and G.Y. Minuk, 1993. Cerebral metabolic and histological effects of thioacetamide-induced liver failure. Am. J. Physiol., 265: 572-578.
    CrossRef  |  
  192. Minuk, G.Y., 1993. Gamma-aminobutyric acid and the liver. Digest. Dis., 11: 45-54.
    CrossRef  |  
  193. Minuk, G.Y. and T. Gauthier, 1993. The effect of gamma aminobutyric acid (GABA) on hepatic regenerative activity following partial hepatectomy in rats. Gastroenterology, 104: 217-221.
  194. Cohen, A.J. and G.Y. Minuk, 1993. The effect of acute alcohol ingestion on Fc-receptor-mediated clearance of IgG-tagged erythrocytes by the reticuloendothelial system in humans. Alcohol, 10: 181-184.
    CrossRef  |  
  195. Bain, V.G. and G.Y. Minuk, 1993. Jaundice, Ascites and Hepatic Encephalopathy. In: Oxford Textbook of Palliative Medicine, Doyle, D., G.W.C. Hanks and N. MacDonald (Eds.). Oxford University Press, Oxford, UK., ISBN-13: 978-0192620286, pp: 337-348.
  196. Semelka, R.C., J.P. Shoenut, M.A. Kroeker, H.M. Greenberg and F.C. Simm et al., 1992. Focal liver disease: Comparison of dynamic contrast-enhanced CT and T2-weighted fat-suppressed, FLASH and dynamic gadolinium-enhanced MR Imaging at 1.5 T1. Radiology, 184: 687-694.
  197. Semelka, R.C., J.P. Shoenut, M.A. Kroeker, H. Hricak, G.Y. Minuk and C.S. Yaffe, 1992. Bile duct disease: Prospective comparison of ERCP, CT and fat suppression MRI. Gastrointest. Radiol., 17: 347-352.
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  198. Minuk, G.Y., G.B. German, K. Bernstein, A. Benarroch, T. Gauthier and L. Sekla, 1992. A pilot study of steroid withdrawal followed by oral acyclovir in the treatment of chronic type B hepatitis. Clin. Invest. Med., 15: 506-512.
    Direct Link  |  
  199. Minuk, G.Y., A.J. Cohen and V. Thompson, 1992. Differences between infected and noninfected patients with acute alcoholic hepatitis. Can. J. Infect. Dis., 3: 240-242.
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  200. Minuk, G.Y., A. Bennaroch and L.X. Ding, 1992. Polyamine transport systems in isolated rat hepatocytes derived from resting and regenerating livers. Am. J. Physiol., 263: 169-173.
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  201. Minuk, G.Y., 1992. GABA and the Liver: The First 40 Years. In: GABA Outside the CNS, Erdo, S.L. (Ed.). Springer-Verlag, Berlin, Germany, ISBN-13: 9783540545323, pp: 143-153.
  202. MacIntosh, E.L., T. Gauthier, N.M. Pettigrew and G.Y. Minuk, 1992. Hepatic fibrosis as a predictor of hepatic regenerative activity after partial hepatectomy in the rat. Hepatology, 17: 307-309.
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  203. MacIntosh, E.L., T. Gauthier, G.K.M. Harding and G.Y. Minuk, 1992. Selective bowel decontamination does not alter the hepatic regenerative response to partial hepatectomy in rats. Gastroenterology, 102: 1403-1405.
  204. MacIntosh, E.L. and G.Y. Minuk, 1992. Hepatic resection in patients with cirrhosis and hepatocellular carcinoma. Surg. Gyne. Obstet., 174: 245-254.
    Direct Link  |  
  205. MacIntosh, E., T. Gauthier, N. Pettigrew and G. Minuk, 1992. Liver regeneration and the effect of exogenous putrescine on regenerative activity after partial hepatectomy in cirrhotic rats. Hepatology, 16: 1428-1433.
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  206. Leader, A., G.Y. Minuk and D. Mortimer, 1992. Seminal plasma Gamma-Aminobutyric Acid (GABA) levels in normospermic men. Clin. Invest. Med., 15: 340-342.
    Direct Link  |  
  207. Ghahary, A., G.Y. Minuk, J. Luo, T. Gauthier and L.J. Murphy, 1992. Effects of partial hepatectomy on hepatic insulinlike growth factor binding protein-1 expression. Hepatology, 15: 1125-1131.
    CrossRef  |  
  208. Minuk, G.Y., T. Gauthier, A. Gaharie and L.J. Murphy, 1991. The effect of GABA on serum and hepatic polyamine concentrations after partial hepatectomy in rats. Hepatology, 14: 685-689.
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  209. Minuk, G.Y., L.E. Nicolle, T. Gauthier and J. Brunka, 1991. Prevalence of antibody to hepatitis C virus in an isolated Canadian Inuit settlement. Can. J. Infect. Dis. Med. Microbiol., 2: 71-73.
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  210. Minuk, G.Y., G.E. Rockman, T. Gauthier, L. Markert, J. Gibson and A. Benarroch, 1991. The effect of long-term, voluntary ethanol consumption on hepatic regeneration in rats. Can. J. Physiol. Pharmacol., 69: 341-345.
    CrossRef  |  Direct Link  |  
  211. Kumar, A. and G.Y. Minuk, 1991. Postinfantile giant cell hepatitis in association with hypereosinophilia. Gastroenterology, 101: 1417-1419.
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  212. Hanley, D.A., L.M. Ayer, C.M. Gundberg and G.Y. Minuk, 1991. Parameters of calcium metabolism during a pilot study of cyclosporin a in patients with symptomatic primary biliary cirrhosis. Clin. Invest. Med., 14: 282-287.
    Direct Link  |  
  213. Hammond, G.W., J. Parker, L. Mimms, R. Tate, L. Sekla and G.Y. Minuk, 1991. Comparison of immunogenicity of two yeast-derived recombinant hepatitis B vaccines. Vaccine, 9: 97-100.
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  214. Minuk, G.Y., T. Gauthier and A. Benarroch, 1990. Changes in serum and hepatic polyamine concentrations after 30%, 70% and 90% partial hepatectomy in rats. Hepatology, 12: 542-546.
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  215. Minuk, G.Y. and W. Thompson, 1990. Biochemical features of alcohol-induced liver disease in native versus non-native Canadians. Can. J. Gastroenterol. Hepatol., 4: 163-166.
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  216. Simons, F., W.T. Watson, X.Y. Chen, G.Y. Minuk and K.J. Simons, 1989. The pharmacokinetics and pharmacodynamics of hydroxyzine in patients with primary biliary cirrhosis. J. Clin. Pharmacol., 29: 809-815.
    CrossRef  |  Direct Link  |  
  217. Parsons, H.G., J.E. Thirsk, J. Frohlich, V. Dias and G.Y. Minuk, 1989. Effect of cyclosporin A on serum lipids in primary biliary cirrhosis patients. Clin. Invest. Med., 12: 386-391.
    PubMed  |  
  218. Minuk, G.Y., N.D. Boyd, D.S. Matheson, M.J. Fritzler and B. Green, 1989. Serum immunoglobulin E levels in patients with primary biliary cirrhosis. J. Allergy Clin. Immunol., 83: 462-466.
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  219. Minuk, G.Y., C.E. Bohme and T.J. Bowen, 1989. Passive and active immunization against hepatitis B virus infection: Optimal scheduling in healthy young adults. Clin. Invest. Med., 12: 175-180.
    PubMed  |  
  220. Minuk, G.Y., 1989. The use of cyclosporin A in non-transplant related liver disorders. Am. J. Gastroenterol., 84: 1345-1345.
  221. Matheson, D.S., B.J. Green and G.Y. Minuk, 1989. Natural killer-cell activity and the response to interferons α, β, and γ in patients with primary biliary cirrhosis. J. Allergy Clin. Immunol., 84: 214-218.
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  222. Winder, T.R., G.Y. Minuk, E.J. Sarjeant and T.P. Seland, 1988. Gamma-Aminobutyric Acid (GABA) and sepsis-related encephalopathy. Can. J. Neuro Sci., 15: 23-25.
    CrossRef  |  Direct Link  |  
  223. Nesbitt, J.A.A. and G.Y. Minuk, 1988. Adult Reye's syndrome. Ann. Emerg. Med., 17: 155-158.
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  224. Minuk, G.Y., L.R. Sutherland, S.C. Pappas, J.K. Kelly and S.E. Martin, 1988. Autoimmune chronic active hepatitis (Lupoid hepatitis) and primary sclerosing cholangitis in two young adult females. Can. J. Gastroenterol. Hepatol., 2: 22-27.
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  225. Minuk, G.Y., J.K. Kelly and W.S. Hwang, 1988. Vitamin A hepatotoxicity in multiple family members. Hepatology, 8: 272-275.
  226. Minuk, G.Y., C.E. Bohme, E. Burgess, N.B. Hershfield and J.K. Kelly et al., 1988. Pilot study of cyclosporin A in patients with symptomatic primary biliary cirrhosis. Gastroenterology, 95: 1356-1363.
    CrossRef  |  Direct Link  |  
  227. Minuk, G.Y., 1988. Hepatic Encephalopathy. In: Modern Concepts in Gastroenterology, Thompson, A.B.R. and E.A. Shaffer (Eds.). Plenum Press, New York, USA., pp: 89-107.
  228. Minuk, G.Y. and W.Y. Lee, 1988. Interferon and immune complex production in healthy individuals undergoing passive and active immunization against hepatitis B virus infection. Med. Sci. Res., 16: 109-110.
  229. Minuk, G.Y. and R. LaFreniere, 1988. Interleukin-1 and interleukin-2 in chronic type B hepatitis (editorial). Gastroenterology, 94: 1094-1096.
  230. Minuk, G.Y. and K.L. Maccannell, 1988. Is the hypotension of cirrhosis a GABA‐mediated process? Hepatology, 8: 73-77.
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  231. Minuk, G.Y. and E.J. Sarjeant, 1988. The effect of (a) neomycin and lactulose treatment on systemic and portal serum GABA levels in rats and (b) pH changes on [3H] GABA binding to isolated rat hepatocytes. Clin. Invest. Med., 11: 373-376.
    PubMed  |  
  232. Minuk, G.Y. and E.J. Sarjeant, 1988. Factors that Influence Systemic GABA Homeostasis in the Setting of Hepatic Encephalopathy. In: Advances in Ammonia Metabolism and Hepatic Encephalopathy, Soeters, P., I.H.P. Wilson, A.J. Meijer and E. Holm (Eds.). Elsevier Science Publishers B.V., Amsterdam, ISBN-13: 9780444809575, pp: 248-251.
  233. Minuk, G.Y. and E.A. Shaffer, 1988. Benign Recurrent Intrahepatic Cholestasis. In: Gastrointestinal and Hepatic Secretions: Mechanism and Control, Davidson, J.S. and E.A. Shaffer (Eds.). The University of Calgary Press, Alberta, Canada, ISBN-13: 978-0919813502, pp: 85-87.
  234. Wang, D.Q., H.H. Cheng, G.Y. Minuk, L.H. Liu and C.M. Anand et al., 1987. Delta hepatitis virus infection in China. Int. J. Epidemiol., 16: 79-83.
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  235. Taylor, R.W., T. Sylwestrowicz, A.E. Kossakowska, S.J. Urbanski and G.Y. Minuk, 1987. Leiomy-sarcoma of the inferior vena cava presenting as Budd-Chiari syndrome. Liver, 7: 201-205.
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  236. Sheppard, M.S., G.Y. Minuk, B. Bhaumick and R.M. Bala, 1987. Insulin-like Growth Factors (IGF) in liver disease: Differential changes of IGF-I and IGF-II. Clin. Invest. Med., 10: 49-53.
    Direct Link  |  
  237. Minuk, G.Y., T.J. Bowen, L. Sekla, G.K.M. Harding and D. Arnold, 1987. The nature of antibody to hepatitis B surface antigen in high risk individuals negative for other hepatitis B viral markers. Am. J. Epidemiol., 126: 44-49.
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  238. Minuk, G.Y., R.C. Lui and J.K. Kelly, 1987. Rupture of the liver associated with acute fatty liver of pregnancy. Am. J. Gastroenterol., 82: 457-460.
  239. Minuk, G.Y., N. Rascanin, R.W. Paul, P.W.K. Lee, K. Buchan and J.K. Kelly, 1987. Reovirus type 3 infection in patients with primary biliary cirrhosis and primary sclerosing cholangitis. J. Hepatol., 5: 8-13.
    CrossRef  |  Direct Link  |  
  240. Minuk, G.Y., L.R. Sutherland, D.A. Wiseman, F.R. MacDonald and D.L. Ding, 1987. A prospective study of the incidence of ultrasound detected intrahepatic and subcapsular hematomas in patients randomized to six or twenty-four hours bed rest following percutaneous liver biopsy. Gastroenterology, 92: 290-293.
  241. Minuk, G.Y., L.H. Sekla and L.E. Nicolle, 1987. Serologic markers for Epstein-Barr virus infection in chronic hepatitis B surface antigen carriers from Northern Canada. J. Infect. Dis., 156: 202-204.
  242. Minuk, G.Y., L.E. Nicole and T. Sherman, 1987. Cryptogenic abscess of the liver: Evidence of underlying reticuloendothelial cell dysfunction. Arch. Surg., 122: 906-908.
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  243. Minuk, G.Y., C.E. Bohme, T.J. Bowen, D.I. Hoar, S. Cassol, M.J. Gill and H.D.C. Clarke, 1987. Efficacy of commercial condoms in the prevention of hepatitis B virus infection. Gastroenterology, 93: 710-714.
    CrossRef  |  Direct Link  |  
  244. Minuk, G.Y., C.E. Bear and E.J. Sarjeant, 1987. Sodium-independent, bicuculline-sensitive [3H] GABA binding to isolated rat hepatocytes. Am. J. Physiol.-Gastrointest. Liver Physiol., 252: G642-G647.
    CrossRef  |  Direct Link  |  
  245. Minuk, G.Y., C. Bohme, N.B. Hershfield, W.Y. Lee and K.L. MacCannell et al., 1987. Fc-receptor mediates clearance of immune complex-like material in Crohn's disease patients with elevated liver enzymes. Can. J. Gastroenterol. Hepatol., 1: 18-22.
    CrossRef  |  Direct Link  |  
  246. Minuk, G.Y. and E.A. Shaffer, 1987. Benign recurrent intrahepatic cholestasis: Evidence for an intrinsic abnormality in hepatocyte secretion. Gastroenterology, 93: 1187-1193.
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  247. Nicolle, L.E., G.Y. Minuk, B. Postl, N. Ling, D.L. Madden and J.H. Hoofnagle, 1986. Cross-sectional seroepidemiologic study of the prevalence of cytomegalovirus and herpes simplex virus infection in a Canadian Inuit (Eskimo) community. Scandinavian J. Infect. Dis., 18: 19-23.
    CrossRef  |  Direct Link  |  
  248. Minuk, G.Y., T.A. Sherman, E.A. Shaffer and J.K. Kelly, 1986. A comparative study of the effects of insulin/glucagon infusions, parenteral amino acids and high dose corticosteroids on survival in a rabbit model of acute fulminant hepatitis. Hepatology, 6: 73-78.
    CrossRef  |  PubMed  |  Direct Link  |  
  249. Minuk, G.Y., N.B. Hershfield, W.Y. Lee, K.L. Maccannell and R. Preshaw et al., 1986. Reticuloendothelial system Fc receptor‐mediated clearance of IgG‐tagged erythrocytes from the circulation of patients with idiopathic ulcerative colitis and chronic liver disease. Hepatology, 6: 1-5.
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  250. Minuk, G.Y., N. Rascanin, E.S. Sarjeant and C.H. Pai, 1986. Sepsis and cholestasis: The in vitro effects of bacterial products on 14C‐taurocholate uptake by isolated rat hepatocytes. Liver Int., 6: 199-204.
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  251. Minuk, G.Y., N. Rascanin and D. Woods, 1986. Effect of amino acids on luminol-dependent chemiluminescence generated by peripheral blood polymorphonuclear leukocytes. J. Clin. Microbiol., 24: 307-309.
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  252. Minuk, G.Y., J. Vergalla, R.G. Hanson, J.H. Hoofnagle, M.M. Frank and E.A. Jones, 1986. Anticomplement receptor activity in the serum of patients with primary biliary cirrhosis. Gut, 27: 324-328.
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  253. Minuk, G.Y., E.A. Shaffer, D.I. Hoar and J. Kelly, 1986. Ground Squirrel Hepatitis Virus (GSHV) infection and hepatocellular carcinoma in the Canadian Richardson ground squirrel (Spermophilus richardsonii). Liver Int., 6: 350-356.
    CrossRef  |  Direct Link  |  
  254. Minuk, G.Y., 1986. Gamma-Aminobutyric Acid (GABA) production by eight common bacterial pathogens. Scandinavian J. Infect. Dis., 18: 465-467.
    CrossRef  |  Direct Link  |  
  255. Minuk, G.Y., 1986. GABAergic Mechanisms and their Functional Importance in the Liver. In: GABAergic Mechanisms in the Mammalian Periphery, Erdo. S.L. and N.G. Bowery (Eds.). Raven Press, New York, USA., ISBN-13: 9780881671933, pp: 325-337.
  256. Minuk, G.Y. and L.E. Nicolle, 1986. Genital herpes and hepatitis in healthy young adults. J. Med. Virol., 19: 269-275.
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  257. Cheng, H.H., D.Q. Wang, G.Y. Minuk, C.M. Anand, T.C. Stowe and K.A. Buchan, 1986. The prevalence of antibody to delta virus in Western Canada. Clin. Invest. Med., 9: 156-159.
    Direct Link  |  
  258. Minuk, G.Y., R.W. Paul and P.W.K. Lee, 1985. The prevalence of antibodies to reovirus type 3 in adults with idiopathic cholestatic liver disease. J. Med. Virol., 16: 55-60.
    CrossRef  |  Direct Link  |  
  259. Minuk, G.Y., N. Ling, B. Postl, J.G. Waggoner, L.E. Nicolle and J.H. Hoofnagle, 1985. The changing epidemiology of hepatitis B virus infection in the Canadian north. Am. J. Epidemiol., 121: 598-604.
    CrossRef  |  Direct Link  |  
  260. Minuk, G.Y., M. Angus, C.M. Brickman, T.J. Lawley, M.M. Frank, J.H. Hoofnagle and E.A. Jones, 1985. Abnormal clearance of immune complexes from the circulation of patients with primary sclerosing cholangitis. Gastroenterology, 88: 166-170.
    CrossRef  |  Direct Link  |  
  261. Minuk, G.Y., E.J. Sarjeant and K. Buchan, 1985. Elevated serum γ-aminobutyric acid levels in children with Reye's syndrome. J. Pediatric Gastroenterol. Nutr., 4: 528-531.
    Direct Link  |  
  262. Minuk, G.Y., A. Winder, E.D. Burgess and E.J. Sarjeant, 1985. Serum gamma-aminobutyric acid (GABA) levels in patients with hepatic encephalopathy. Hepato-Gastroenterol., 32: 171-174.
    Direct Link  |  
  263. Minuk, G.Y. and E.J. Sarjeant, 1985. Insulin and glucagon secretion by the dog pancreas during intravenous and oral administration of Gamma Aminobutyric Acid (GABA). Hormone Metabolic Res., 17: 313-314.
  264. Minuk, G.Y., J. Vergalla, P. Ferenci and E.A. Jones, 1984. Identification of an acceptor system for γ‐aminobutyric acid on isolated rat hepatocytes. Hepatology, 4: 180-185.
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  265. Minuk, G.Y. and E.J. Sarjeant, 1984. Gamma Aminobutyric Acid (GABA) and hepatic bile flow in the adult rat. Clin. Invest. Med., 7: 193-197.
    Direct Link  |  
  266. Hoofnagle, J.H., R.G. Hanson, G.Y. Minuk, S.C. Pappas and D.F. Schafer et al., 1984. Randomized controlled trial of adenine arabinoside monophosphate for chronic type B hepatitis. Gastroenterology, 86: 150-157.
    Direct Link  |  
  267. Hanson, R.G., J.H. Hoofnagle, G.Y. Minuk, R.H. Purcell and J.L. Gerin, 1984. Cell-mediated immunity to hepatitis B surface antigen in man. Clin. Exp. Immunol., 57: 257-264.
    Direct Link  |  
  268. Minuk, G.Y., J.H. Hoofnagle, V.J. McAuliffe and R.H. Purcell, 1983. IgM antibody responses to hepatitis B surface antigen in recipients of hepatitis B virus vaccine. J. Infect. Dis., 148: 330-330.
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  269. Maturi, M.F., J.D. Fine, E.H. Schaffer, G.Y. Minuk and J.H. Hoofnagle, 1983. Pyoderma gangrenosum associated with primary biliary cirrhosis. Arch. Internal Med., 143: 1261-1263.
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  270. Chung, W.K., H.S. Sun, D.H. Park, G.Y. Minuk and J.H. Hoofnagle, 1983. Primary hepatocellular carcinoma and hepatitis B virus infection in Korea. J. Med. Virol., 11: 99-104.
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  271. Minuk, G.Y., L.E. Nicolle, B. Postl, J.G. Waggoner and J.H. Hoofnagle, 1982. Hepatitis virus infection in an isolated Canadian Inuit (Eskimo) population. J. Med. Virol., 10: 255-264.
    CrossRef  |  Direct Link  |  
  272. Minuk, G.Y., J.H. Hoofnagle and E.A. Jones, 1982. Systemic side effects from the intrabiliary infusion of monooctanoin for the dissolution of gallstones. J. Clin. Gastroenterol., 4: 133-136.
    Direct Link  |  
  273. Minuk, G.Y., J.G. Waggoner, R. Jernigan, L.E. Nicolle, B. Postl and J.H. Hoofnagle, 1982. Prevalence of antibody to hepatitis A virus in a Canadian Inuit community. Can. Med. Assoc. J., 127: 850-885.
    Direct Link  |  
  274. Hoofnagle, J.H., G.Y. Minuk, G.M. Dusheiko, D.F. Schafer and R. Johnson et al., 1982. Adenine arabinoside 5'‐monophosphate treatment of chronic type B hepatitis. Hepatology, 2: 784-788.
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