Hi, I am Ahmad Aljada, My LiveDNA is 1.5988
 
   
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Dr. Ahmad Aljada
 
Highest Degree: Ph.D. in Biochemistry from State University of New York, USA
 
Institute: Kind Saud Bin Abdulaziz University for Health Sciences, Saudi Arabia
 
Area of Interest: Biomedical Sciences
  •   Pharmacology
  •   Angiogenesis
  •   Metabolism
  •   Diabetes
 
URL: http://livedna.org/1.5988
 
My SELECTED Publications
1:   Ahmad, A., S.K. Ashwin and S.A. Mousa, 2009. Peroxisome proliferator-activated receptor agonists: Do they increase cardiovascular risk? PPAR Res. 10.1155/2009/460764.
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2:   Al-Mubarak, S., S. Ciancio, A. Aljada, P. Mohanty, P. Mohanty, C. Ross and P. Dandona, 2002. Comparative evaluation of adjunctive oral irrigation in diabetics. J. Clin. Periodontol., 29: 295-300.
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3:   Aljada, A. and P. Dandona, 1998. Nitric Oxide Synthase. In: Free Radical and Antioxidant Protocols, Armstrong, D. (Ed.). Springer, New York, USA., ISBN: 9780896034723, pp: 191-198.
4:   Aljada, A. and P. Dandona, 2000. Effect of insulin on human aortic endothelial nitric oxide synthase. Metabolism, 49: 147-150.
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5:   Aljada, A. and S.A. Mousa, 2012. Metformin and neoplasia: Implications and indications. Pharmacol. Therapeut., 133: 108-115.
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6:   Aljada, A., 2003. Endothelium, inflammation and diabetes. Metab. Syndrome Related Disord., 1: 3-21.
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7:   Aljada, A., A. Saleh and S.A. Mousa, 2013. Induction of stress induced premature senescence by sirtuin-7 inhibition: A novel mechanism for multi drug resistance. J. Cancer Sci. Ther., 5: 182-189.
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8:   Aljada, A., H. Ghanim and P. Dandona, 2002. Activation of Nuclear Factor-κB (NF-κB) in Mononuclear Cells (MNC). In: Oxidants and Antioxidants: Ultrastructure and Molecular Biology Protocols, Armstrong, D. (Ed.). Springer, New York, USA., ISBN-13: 9780896038516, pp: 105-110.
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9:   Aljada, A., H. Ghanim and P. Dandona, 2002. Translocation of p47phox and Activation of NADPH Oxidase in Mononuclear Cells. In: Oxidants and Antioxidants: Ultrastructure and Molecular Biology Protocols, Armstrong, D. (Ed.). Springer, New York, USA., ISBN-13: 9780896038516, pp: 99-103.
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10:   Aljada, A., H. Ghanim, E. Assian and P. Dandona, 2002. Tumor necrosis factor-[alpha] inhibits insulin-induced increase in endothelial nitric oxide synthase and reduces insulin receptor content and phosphorylation in human aortic endothelial cells. Metabolism, 51: 487-491.
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11:   Aljada, A., H. Ghanim, E. Assian, P. Mohanty, W. Hamouda, R. Garg and P. Dandona, 1999. Increased IκB expression and diminished nuclear NF-κB in human mononuclear cells following hydrocortisone injection. J. Clin. Endocrinol. Metab., 84: 3386-3389.
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12:   Aljada, A., H. Ghanim, J. Friedman, R. Garg, P. Mohanty and P. Dandona, 2001. Troglitazone reduces the expression of PPARγ while stimulating that of PPARα in mononuclear cells in obese subjects. J. Clin. Endocrinol. Metab., 86: 3130-3133.
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13:   Aljada, A., H. Ghanim, P. Mohanty, D. Hofmeyer, D. Tripathy and P. Dandona, 2001. Hydrocortisone suppresses intranuclear Activator-Protein-1 (AP-1) binding activity in mononuclear cells and plasma Matrix Metalloproteinase 2 and 9 (MMP-2 and MMP-9). J. Clin. Endocrinol. Metab., 86: 5988-5991.
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14:   Aljada, A., H. Ghanim, P. Mohanty, N. Kapur and P. Dandona, 2002. Insulin inhibits the pro-inflammatory transcription factor early growth response gene-1 (Egr)-1 expression in Mononuclear Cells (MNC) and reduces plasma Tissue Factor (TF) and Plasminogen Activator Inhibitor-1 (PAI-1) concentrations. J. Clin. Endocrinol. Metab., 87: 1419-1422.
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15:   Aljada, A., H. Ghanim, P. Mohanty, T. Syed, A. Bandyopadhyay and P. Dandona, 2004. Glucose intake induces an increase in activator protein 1 and early growth response 1 binding activities, in the expression of tissue factor and matrix metalloproteinase in mononuclear cells and in plasma tissue factor and matrix metalloproteinase concentrations. Am. J. Clin. Nutr., 80: 51-57.
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16:   Aljada, A., H. Ghanim, R. Saadeh and P. Dandona, 2001. Insulin inhibits NFκB and MCP-1 expression in human aortic endothelial cells. J. Clin. Endocrinol. Metab., 86: 450-453.
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17:   Aljada, A., J. Friedman, H. Ghanim, P. Mohanty, D. Hofmeyer, A. Chaudhuri and P. Dandona, 2006. Glucose ingestion induces an increase in intranuclear nuclear factor κB, a fall in cellular inhibitor κB and an increase in tumor necrosis factor α messenger RNA by mononuclear cells in healthy human subjects. Metabolism, 55: 1177-1185.
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18:   Aljada, A., L. Dong and S.A. Mousa, 2010. Sirtuin-targeting drugs: Mechanisms of action and potential therapeutic applications. Curr. Opin. Invest. Drugs, 11: 1158-1168.
PubMed  |  
19:   Aljada, A., L. O'Connor, Y.Y. Fu and S.A. Mousa, 2008. PPARγ ligands, rosiglitazone and pioglitazone, inhibit bFGF- and VEGF-mediated angiogenesis. Angiogenesis, 11: 361-367.
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20:   Aljada, A., P. Mohanty, H. Ghanim, T. Abdo, D. Tripathy, A. Chaudhuri and P. Dandona, 2004. Increase in intranuclear nuclear factor κB and decrease in inhibitor κB in mononuclear cells after a mixed meal: Evidence for a proinflammatory effect. Am. J. Clin. Nutr., 79: 682-690.
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21:   Aljada, A., R. Garg, H. Ghanim, P. Mohanty, W. Hamouda, E. Assian and P. Dandona, 2001. Nuclear factor-κB suppressive and inhibitor-κB stimulatory effects of troglitazone in obese patients with type 2 diabetes: Evidence of an antiinflammatory action? J. Clin. Endocrinol. Metab., 86: 3250-3256.
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22:   Aljada, A., R. Saadeh, E. Assian, H. Ghanim and P. Dandona, 2000. Insulin inhibits the expression of intercellular adhesion molecule-1 by human aortic endothelial cells through stimulation of nitric oxide. J. Clin. Endocrinol. Metab., 85: 2572-2575.
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23:   Armstrong, D., A. Augustin, R. Spengler, A. Aljada, T. Nickola, F. Grus and F. Koch, 1998. Detection of vascular endothelial growth factor and tumor necrosis factor alpha in epiretinal membranes of proliferative diabetic retinopathy, proliferative vitreoretinopathy and macular pucker. Ophthalmologica, 212: 410-414.
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24:   Armstrong, D., T. Ueda, T. Ueda, A. Aljada and R. Browne et al., 1998. Lipid hydroperoxide stimulates retinal neovascularization in rabbit retina through expression of tumor necrosis factor-a, vascular endothelial growth factor and platelet-derived growth factor. Angiogenesis, 2: 93-104.
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25:   Armstrong, D., T. Ueda, T. Ueda, T. Hiramitsu and R. Stockton et al., 1998. Lipid Hydroperoxide Induced Retinal Pathology. In: Pathophysiology of Lipid Peroxides and Related Free Radicals, Yagi, K. (Ed.). Japan Scientific Societies Press, Tokyo, Japan, pp: 57-76.
26:   Chaudhuri, A., D. Janicke, M. Wilson, H. Ghanim, G.E. Wilding, A. Aljada and P. Dandona, 2007. Effect of modified glucose-insulin-potassium on free fatty acids, matrix metalloproteinase and myoglobin in ST-elevation myocardial infarction. Am. J. Cardiol., 100: 1614-1618.
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27:   Chaudhuri, A., D. Janicke, M.F. Wilson, D. Tripathy and R. Garg et al., 2004. Anti-inflammatory and profibrinolytic effect of insulin in acute ST-segment-elevation myocardial infarction. Circulation, 109: 849-854.
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28:   Dandona, P. and A. Aljada, 2002. A rational approach to pathogenesis and treatment of type 2 diabetes mellitus, insulin resistance, inflammation and atherosclerosis. Am. J. Cardiol., 90: 27-33.
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29:   Dandona, P. and A. Aljada, 2004. Advances in diabetes for the millennium: Diabetes and the endothelium. MedGenMed, Vol. 6. .
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30:   Dandona, P. and A. Aljada, 2004. Endothelial dysfunction in patients with type 2 diabetes and the effects of thiazolidinedione antidiabetic agents. J. Diabetes Complications, 18: 91-102.
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31:   Dandona, P., A. Aljada and A. Bandyopadhyay, 2003. Hyperglycemia after myocardial infarction: Response to Dhatariya. Diabetes Care, 26: 2222-2223.
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32:   Dandona, P., A. Aljada and A. Bandyopadhyay, 2003. The potential therapeutic role of insulin in acute myocardial infarction in patients admitted to intensive care and in those with unspecified hyperglycemia. Diabetes Care, 26: 516-519.
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33:   Dandona, P., A. Aljada and A. Bandyopadhyay, 2004. Inflammation: The link between insulin resistance, obesity and diabetes. Trends Immunol., 25: 4-7.
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34:   Dandona, P., A. Aljada and A. Chaudhuri, 2003. Vascular reactivity and thiazolidinediones. Am. J. Med., 115: 81-86.
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35:   Dandona, P., A. Aljada and P. Mohanty, 2002. The anti-inflammatory and potential anti-atherogenic effect of insulin: A new paradigm. Diabetologia, 45: 924-930.
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36:   Dandona, P., A. Aljada, A. Chaudhuri and A. Bandyopadhyay, 2003. The potential influence of inflammation and insulin resistance on the pathogenesis and treatment of atherosclerosis-related complications in type 2 diabetes. J. Clin. Endocrinol. Metab., 88: 2422-2429.
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37:   Dandona, P., A. Aljada, A. Chaudhuri and H. Ghanim, 2007. Oxidative Inflammatory Stress in Obesity and Diabetes. In: Stress in Health and Disease, Arnetz, B. and R. Ekman (Eds.). Wiley-VCH, New York, USA., pp: 307-310.
38:   Dandona, P., A. Aljada, A. Chaudhuri and P. Mohanty, 2004. Endothelial dysfunction, inflammation and diabetes. Rev. Endocrine Metab. Disorders, 5: 189-197.
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39:   Dandona, P., A. Aljada, A. Chaudhuri and P. Mohany, 2006. Endothelial Dysfunction in Diabetes. In: Clinical Diabetes: Translating Research into Practice, Fonseca, V.A. (Ed.). Elsevier Inc., Philadelphia, PA., USA., pp: 78-88.
40:   Dandona, P., A. Aljada, A. Chaudhuri, P. Mohanty and R. Garg, 2005. Metabolic syndrome: A comprehensive perspective based on interactions between obesity, diabetes and inflammation. Circulation, 111: 1448-1454.
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41:   Dandona, P., A. Aljada, H. Ghanim, P. Mohanty, C. Tripathy, D. Hofmeyer and A. Chaudhuri, 2004. Increased plasma concentration of macrophage migration inhibitory factor (MIF) and MIF mRNA in mononuclear cells in the obese and the suppressive action of metformin. J. Clin. Endocrinol. Metab., 89: 5043-5047.
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42:   Dandona, P., A. Aljada, H. Ghanim, P. Mohanty, W. Hamouda and W. Al-Haddad, 2001. Acute suppressive effect of hydrocortisone on p47phox subunit of nicotinamide adenine dinucleotide phosphate oxidase. Metabolism, 50: 548-552.
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43:   Dandona, P., A. Aljada, P. Mohanty, H. Ghanim, A. Bandyopadhyay and A. Chaudhuri, 2003. Insulin suppresses plasma concentration of vascular endothelial growth factor and matrix metalloproteinase-9. Diabetes Care, 26: 3310-3314.
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44:   Dandona, P., A. Aljada, P. Mohanty, H. Ghanim, W. Hamouda, E. Assian and S. Ahmad, 2001. Insulin inhibits intranuclear nuclear factor κB and stimulates IκB in mononuclear cells in obese subjects: Evidence for an anti-inflammatory effect? J. Clin. Endocrinol. Metab., 86: 3257-3265.
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45:   Dandona, P., A. Aljada, R. Garg and P. Mohanty, 1999. Increase in plasma interleukin-10 following hydrocortisone injection. J. Clin. Endocrinol. Metab., 84: 1141-1144.
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46:   Dandona, P., A. Chaudhuri and A. Aljada, 2004. Endothelial dysfunction and hypertension in diabetes mellitus. Med. Clin. North Am., 88: 911-931.
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47:   Dandona, P., A. Chaudhuri and A. Aljada, 2004. The relationship of fasting serum radioimmune insulin levels to incident coronary heart disease in an insulin-treated diabetic cohort. J. Clin. Endocrinol. Metab., 89: 5868-5869.
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48:   Dandona, P., D. Nix, M.F. Wilson, A. Aljada, J. Love, M. Assicot and C. Bohuon, 1994. Procalcitonin increase after endotoxin injection in normal subjects. J. Clin. Endocrinol. Metab., 79: 1605-1608.
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49:   Dandona, P., K. Thusu, U. Khurana, J. Love, A. Aljada and S. Mousa, 1996. Calcium, calmodulin and protein kinase C dependence of platelet shape change. Thrombosis Res., 81: 163-175.
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50:   Dandona, P., M. Suri, W. Hamouda, A. Aljada, Y. Kumbkarni and K. Thusu, 1999. Hydrocortisone-induced inhibition of reactive oxygen species by polymorphonuclear neutrophils. Crit. Care Med., 27: 2442-2444.
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51:   Dandona, P., P. Mohanty, A. Chaudhuri, R. Garg and A. Aljada, 2005. Insulin infusion in acute illness. J. Clin. Invest., 115: 2069-2072.
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52:   Dandona, P., P. Mohanty, H. Ghanim, A. Aljada and R. Browne et al., 2001. The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation and protein carbonylation. J. Clin. Endocrinol. Metab., 86: 355-362.
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53:   Dandona, P., P. Mohanty, W. Hamouda, A. Aljada, Y. Kumbkarni and R. Garg, 1999. Effect of dexamethasone on reactive oxygen species generation by leukocytes and plasma interleukin-10 concentrations: A pharmacodynamic study. Clin. Pharmacol. Ther., 66: 58-65.
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54:   Dandona, P., P. Mohanty, W. Hamouda, H. Ghanim, A. Aljada, R. Garg and V. Kumar, 2001. Inhibitory effect of a two day fast on Reactive Oxygen Species (ROS) generation by leucocytes and plasma ortho-tyrosine and meta-tyrosine concentrations. J. Clin. Endocrinol. Metab., 86: 2899-2902.
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55:   Dandona, P., R. Karne, H. Ghanim, W. Hamouda, A. Aljada and C.H. Magsino Jr., 2000. Carvedilol inhibits reactive oxygen species generation by leukocytes and oxidative damage to amino acids. Circulation, 101: 122-124.
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56:   Dandona, P., R. Weinstock, K. Thusu, E. Abdel-Rahman, A. Aljada and T. Wadden, 1998. Tumor necrosis factor-α in sera of obese patients: Fall with weight loss. J. Clin. Endocrinol. Metab., 83: 2907-2910.
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57:   Dandona, P., S. Dhindsa, A. Aljada and R. Garg, 2003. Insulin as an anti-inflammatory and antiatherosclerotic hormone. Clin. Cornerstone Suppl., 4: S13-S20.
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58:   Dandona, P., T. Qutob, W. Hamouda, F. Bakri, A. Aljada and Y. Kumbkarni, 1999. Heparin inhibits reactive oxygen species generation by polymorphonuclear and mononuclear leucocytes. Thrombosis Res., 96: 437-443.
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59:   Dandona, P., V. Kumar, A. Aljada, H. Ghanim and T. Syed et al., 2003. Angiotensin II receptor blocker valsartan suppresses reactive oxygen species generation in leukocytes, nuclear factor-κB, in mononuclear cells of normal subjects: Evidence of an antiinflammatory action. J. Clin. Endocrinol. Metab., 88: 4496-4501.
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60:   Dhindsa, S., D. Tripathy, N. Sanalkumar, S. Ravishankar, H. Ghanim, A. Aljada and P. Dandona, 2005. Free fatty acid-induced insulin resistance in the obese is not prevented by rosiglitazone treatment. J. Clin. Endocrinol. Metab., 90: 5058-5063.
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61:   Dhindsa, S., D. Tripathy, P. Mohanty, H. Ghanim, T. Syed and A. Aljada, 2004. Differential effects of glucose and alcohol on reactive oxygen species generation and intranuclear nuclear factor-κB in mononuclear cells. Metabolism-Clin. Exp., 53: 330-334.
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62:   Doria, J. and A. Aljada, 2009. Insulin as Modulator of Adipose Inflammation. In: Adipose Tissue and Inflammation, Awad, A.B. and P.G. Bradford (Eds.). Chapter 6, CRC Press, Boca Raton, FL., USA., ISBN-13: 978-1420091304, pp: 99-114.
63:   Fonseca, V.A., A. Stone, M. Munshi, B.S. Baliga and A. Aljada et al., 1997. Oxidative stress in diabetic macrovascular disease: Does homocysteine play a role? South Med. J., 90: 903-906.
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64:   Garg, R., Y. Kumbkarni, A. Aljada, P. Mohanty, H. Ghanim, W. Hamouda and P. Dandona, 2000. Troglitazone reduces reactive oxygen species generation by leukocytes and lipid peroxidation and improves flow-mediated vasodilatation in obese subjects. Hypertension, 36: 430-435.
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65:   Ghanim, H., A. Aljada, D. Hofmeyer, T. Syed, P. Mohanty and P. Dandona, 2004. Circulating mononuclear cells in the obese are in a proinflammatory state. Circulation, 110: 1564-1571.
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66:   Ghanim, H., A. Aljada, N. Daoud, R. Deopurkar, A. Chaudhuri and P. Dandona, 2007. Role of inflammatory mediators in the suppression of insulin receptor phosphorylation in circulating mononuclear cells of obese subjects. Diabetologia, 50: 278-285.
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67:   Ghanim, H., R. Garg, A. Aljada, P. Mohanty and Y. Kumbkarni et al., 2001. Suppression of nuclear factor-κB and stimulation of inhibitor κB by troglitazone: Evidence for an anti-inflammatory effect and a potential antiatherosclerotic effect in the obese. J. Clin. Endocrinol. Metab., 86: 1306-1312.
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68:   Ghanim, H., S. Dhindsa, A. Aljada, A. Chaudhuri, P. Viswanathan and P. Dandona, 2006. Low-dose rosiglitazone exerts an antiinflammatory effect with an increase in adiponectin independently of free fatty acid fall and insulin sensitization in obese type 2 diabetics. J. Clin. Endocrinol. Metab., 91: 3553-3558.
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69:   Harris, L.M., D. Armstrong, R. Browne, A. Aljada and R. Peer et al., 1998. Premature peripheral vascular disease: Clinical profile and abnormal lipid peroxidation. Cardiovasc. Surg., 6: 188-193.
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70:   Iwai, S., A. Aljada, A. Higa, T. Nakanishi-Ueda and S. Fukuda et al., 2006. Activation of AP-1 and increased synthesis of MMP-9 in the rabbit retina induced by lipid hydroperoxide. Curr. Eye Res., 31: 337-346.
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71:   Magsino Jr., C.H., W. Hamouda, H. Ghanim, R. Browne, A. Aljada and P. Dandona, 2000. Effect of triiodothyronine on reactive oxygen species generation by leukocytes, indices of oxidative damage and antioxidant reserve. Metabolism, 49: 799-803.
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72:   Magsino Jr., C.H., W. Hamouda, V. Bapna, H. Ghanim, I.A. Abu-Reish, A. Aljada and P. Dandona, 2000. Nadolol inhibits reactive oxygen species generation by leukocytes and linoleic acid oxidation. Am. J. Cardiol., 86: 443-448.
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73:   Mohanty, P., A. Aljada, H. Ghanim, D. Hofmeyer and D. Tripathy et al., 2004. Evidence for a potent antiinflammatory effect of rosiglitazone. J. Clin. Endocrinol. Metab., 89: 2728-2735.
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74:   Mohanty, P., H. Ghanim, W. Hamouda, A. Aljada, R. Garg and P. Dandona, 2002. Both lipid and protein intakes stimulate increased generation of reactive oxygen species by polymorphonuclear leukocytes and mononuclear cells. Am. J. Clin. Nutr., 75: 767-772.
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75:   Mohanty, P., W. Hamouda, R. Garg, A. Aljada, H. Ghanim and P. Dandona, 2000. Glucose challenge stimulates Reactive Oxygen Species (ROS) generation by leucocytes. J. Clin. Endocrinol. Metab, 85: 2970-2973.
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76:   Mousa, S.A., F. Zhang, A. Aljada, S. Chaturvedi and M. Takieddin et al., 2007. Pharmacokinetics and pharmacodynamics of oral heparin solid dosage form in healthy human subjects. J. Clin. Pharmacol., 47: 1508-1520.
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77:   Mousa, S.A., J.J. Bergh, E. Dier, A. Rebbaa and L.J. O'Connor et al., 2008. Tetraiodothyroacetic acid, a small molecule integrin ligand, blocks angiogenesis induced by vascular endothelial growth factor and basic fibroblast growth factor. Angiogenesis, 11: 183-190.
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78:   Steinhorn, D.M., M.C. Papo, A.T. Rotta, A. Aljada, B.P. Fuhrman and P. Dandona, 1999. Liquid ventilation attenuates pulmonary oxidative damage. J. Crit. Care, 14: 20-28.
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79:   Tripathy, D., A. Aljada and P. Dandona, 2003. Free Fatty Acids (FFA) and endothelial dysfunction; role of increased oxidative stress and inflammation. Diabetologia, 46: 300-301.
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80:   Tripathy, D., P. Mohanty, S. Dhindsa, T. Syed and H. Ghanim, A. Aljada and P. Dandona, 2003. Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects. Diabetes, 52: 2882-2887.
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81:   Ueda, T., T. Ueda, S. Fukuda, R. Browne and E. Jenis et al., 1998. Lipid hydroperoxide-induced Tumor Necrosis Factor (TNF)-α, vascular endothelial growth factor and neovascularization in the rabbit cornea: Effect of TNF inhibition. Angiogenesis, 1: 174-184.
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