Dr. Mark Stephen Kindy

Dr. Mark Stephen Kindy

Professor
Medical University of South Carolina, USA


Highest Degree
Ph.D. in Biochemistry from Boston University School of Medicine, USA

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Area of Interest:

Biomedical Sciences
100%
Biochemistry
62%
Gene Expression
90%
Amyloid Formation
75%
Alzheimer`s Disease
55%

Selected Publications

  1. Yun, X., V. Maximov, J. Yu, H. Zhu, A. Vertegel and M.S. Kindy, 2013. Nanoparticles for targeted delivery of antioxidant enzymes to the brain following cerebral ischemia and reperfusion injury. J. Cereb. Blood Flow Metab., 34: 583-592.
    PubMed  |  

  2. Krishna, V., S. Konakondla, J. Nicholas, A. Varma, M. Kindy and X. Wen, 2013. Biomaterial-based interventions for neuronal regeneration and functional recovery in rodent model of spinal cord injury: A systematic review. J. Spinal Cord Med., 36: 174-190.
    PubMed  |  

  3. Hollis, B.W., D.T. Marshall, S.J. Savage, E. Garrett-Mayer, M.S. Kindy and S. Gattoni-Celli, 2013. Vitamin D3 supplementation, low-risk prostate cancer and health disparities. J. Steroid Biochem. Molec. Biol., 136: 233-237.
    PubMed  |  

  4. Zhang, W., H. Li, Z. Xing, H. Yuan, M.S. Kindy and Z.Z. Li, 2012. Expression of mRNAs for PPT, CGRP, NF-200, and MAP-2 in cocultures of dissociated DRG neurons and skeletal muscle cells in administration of NGF or NT-3. Folia Histochemica Cytobiologica, 50: 312-318.

  5. Shaver, K.G., C.A. Blair, M.S. Kindy and Davis, 2012. Approaching the PSED: Some assembly required. J. Small Bus. Strategy, 22: 99-114.

  6. Moussaieff, A., J. Yu, H. Zhu, S. Gattoni-Celli, E. Shohami and M.S. Kindy, 2012. Protective effects of incensole acetate on cerebral ischemic injury. Brain Res., 1443: 89-97.
    PubMed  |  

  7. Marshall, D.T., S.J. Savage, E. Garrett-Mayer, T.E. Keane and B.W. Hollis et al., 2012. Vitamin D3 supplementation at 4,000 IU per day for one year correlates with a decrease of positive cores at repeat biopsy in subjects with low-risk prostate cancer under active surveillance. J. Clin. Endocrinol. Metabolism, 97: 2315-2324.
    Direct Link  |  

  8. Krishna, V., C. Lazaridis, D. Ellegala, S. Glazier, M. Kindy, M. Spampinato and J.A. Chalela, 2012. Spinal cord infarction associated with subarachnoid hemorrhage. Clin. Neurol. Neurosurgery, 114: 1030-1032.
    PubMed  |  

  9. Garrett-Mayer, E., C. Wagner, B.W. Hollis, M.S. Kindy and S. Gattoni-Celli, 2012. Vitamin D3 supplementation (4000 IU per day for one year) eliminates differences in circulating 25(OH)D between African-American and Caucasian men. Am. J. Clin. Nutr., 96: 332-336.
    PubMed  |  

  10. Elvington, A., C. Atkinson, L. Kulik, Z. Zhu and J. Yu et al., 2012. Pathogenic natural antibodies propagate cerebral injury following ischemic stroke in mice. J. Immunol., 188: 1460-1468.
    PubMed  |  

  11. Elvington, A., C. Atkinson, H. Zhu, J. Yu and K. Takahashi et al., 2012. Role of alternative and terminal complement pathways in propagating inflammation and injury following murine ischemic stroke. J. Immunol., 189: 4640-4647.
    Direct Link  |  

  12. Yu, J., M. Gattoni-Celli, H. Zhu, N.R. Bhat, K. Sambamurti, S. Gattoni-Celli and M.S. Kindy, 2011. Vitamin D3-Enriched diet correlates with a decrease of amyloid plaques in the brain of APP transgenic mice. J. Alz. Disease, 25: 295-307.

  13. Sambamurti, K., N.H. Greig, T. Utsuki, E.L. Barnwell and E. Sharma et al., 2011. Targets for AD treatment: Conflicting messages from γ-secretase inhibitors. J. Neurochem., 117: 359-374.
    CrossRef  |  PubMed  |  Direct Link  |  

  14. Quinn, T.M., J.J. Taylor, J.A. Magarik, E. Vought, M.S. Kindy and D.B. Ellegala, 2011. Decompressive craniectomy: Technical note. Acta Neurol. Scand., 123: 239-244.
    PubMed  |  

  15. Pirlo, R.K., A.J. Sweeney, B.R. Ringeisen, M. Kindy and B.Z. Gao, 2011. Biochip/laser cell deposition system to assess polarized axonal growth from single neurons and neuron/glia pairs in microchannels with novel asymmetrical geometries. Biomicrofluidics, Vol. 30. .
    PubMed  |  

  16. Novgorodov, S.A., D.A. Chudakova, B.W. Wheeler, J. Bielawski, M.S. Kindy, L.M. Obeid and T.I. Gudz, 2011. Developmentally regulated ceramide synthase 6 increases mitochondrial Ca2+-loading capacity and promotes apoptosis. J. Biol. Chem., 286: 4644-4658.

  17. Hook, V., L. Funkelstein, J. Wegrzyn, S. Bark, M. Kindy and G. Hook, 2011. Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimers disease. Biochim. Biophys. Acta, 1824: 89-104.
    CrossRef  |  PubMed  |  

  18. Hook, G., V. Hook and M.S. Kindy, 2011. The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficit in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity. J. Alz. Dis., 26: 387-408.
    PubMed  |  

  19. De Taboada, L., J. Yu, S. El-Amouri, J. Streeter and M.S. Kindy, 2011. Transcranial Laser Therapy (TLT) attenuates Aβ peptide neuropathology in APP transgenic mice. J. Alzheimers Dis., 23: 521-531.

  20. Vest, R.S., H. O'Leary, M.S. Kindy and K.U. Bayer, 2010. Effective post-insult neuroprotection by a novel CaMKII inhibitor. J. Biol. Chem., 285: 20675-20682.
    PubMed  |  

  21. Varghese, K., P. Molnar, M. Das, N. Bhargava, S. Lambert, M. Kindy and J.J. Hickman, 2010. A new target for amyloid beta toxicity validated by standard and high-throughput electrophysiology. PLoS Biol., Vol. 5. 10.1371/journal.pone.0008643.
    CrossRef  |  Direct Link  |  

  22. Qiao, F., C. Atkinson, A. Shunmugavel, B.P. Morgan, M.S. Kindy, H. Song and S. Tomlinson, 2010. The alternative and terminal pathways of complement mediate post-traumatic spinal cord inflammation and injury. Am. J. Pathol., 177: 3061-3070.
    PubMed  |  

  23. Hook, V., G. Hook and M.S. Kindy, 2010. Pharmacogenetic features of inhibitors to Cathepsin B that improve memory deficit and reduces beta-amyloid related to Alzheimers disease. Biol. Chem., 391: 861-872.
    PubMed  |  

  24. Ellis, B.C., S. Gattoni-Celli and M.S. Kindy, 2010. The impact of methylmercury on the vitamin D3-induced transcriptomic response in dolphin skin cells. Biol. Chem., 291: 245-258.

  25. Chi, L., J. Yu, H. Zhu, X. Li and S. Zhu et al., 2010. Altered neuronal response to tumor necrosis factor-alpha in spinal cord injury. Neural Regenerat. Res., 5: 917-926.

  26. Varghese, K., P. Molnar, M. Stancescu, M. Das, N. Bhargava, M.S. Kindy and J.J. Hickman, 2009. Regeneration and characterization of adult mouse hippocampal neurons in a defined in vitro system. J. Neurosci. Methods, 177: 51-59.
    CrossRef  |  

  27. Li, Y., T.A. Perry, M.S. Kindy, B.K. Harvey and D. Tweedie et al., 2009. GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism. Proc. Nat. Acad. Sci. USA., 106: 1285-1290.
    CrossRef  |  

  28. Kwon, B.K., J. Roy, J.H. Lee, E.B. Okon, H. Zhang, J.C. Marx and M.S. Kindy, 2009. Magnesium chloride in a polyethylene glycol formulation as a neuroprotective therapy for acute spinal cord injury: Preclinical refinement and optimization. J. Neurotrauma, 26: 1379-1393.
    PubMed  |  

  29. Hook, V.Y., M. Kindy, T. Reinheckel, C. Peters and G. Hook, 2009. Genetic cathepsin B deficiency reduces betaamyloid in transgenic mice expressing human wild-type amyloid precursor protein. Biochem. Biophys. Res. Commun., 386: 284-288.
    PubMed  |  

  30. Ellis, B.C., S. Gattoni-Celli, A. Mancia and M.S. Kindy, 2009. The vitamin D3 transcriptomic response in skin cells derived from the Atlantic bottlenose dolphin. Develop. Comp. Immunol., 33: 901-912.
    PubMed  |  

  31. Bhargava, N., M. Das, A.S. Karakoti, S. Patil and J.F. Kang et al., 2009. Regeneration of adult mice motoneurons utilizing a defined system and anti-oxidant nanoparticles. J. Nanoneurosci., 1: 130-143.
    Direct Link  |  

  32. Yu, J., H. Zhu, D. Ko and M.S. Kindy, 2008. Motoneuronotrophic factor analog GM6 reduces infarct volume and behavioral deficits following transient ischemia in the mouse. Brain Res., 1238: 143-153.
    CrossRef  |  

  33. Thirumangalakudi, L., A. Prakasam, R. Zhang, H. Bimonte-Nelson, K. Sambamurti, M.S. Kindy and N.R. Bhat, 2008. High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice. J. Neurochem., 106: 475-485.
    CrossRef  |  

  34. Pettigrew, L.C., M.L. Holtz, Y. Li, J. Yu and R.J. Kryscio et al., 2008. Focal cerebral ischemia in the TNFalpha-transgenic rat. J. Neuroinflammation, Vol. 5. 10.1186/1742-2094-5-47.
    CrossRef  |  

  35. Hook, V.Y., M. Kindy and G. Hook, 2008. Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, betasecretase site of the amyloid precursor protein. J. Biol. Chem., 283: 7745-7753.
    CrossRef  |  

  36. Govindaswami, M., S.A. Brown, J. Yu, H. Zhu, P.D. Bishop, M.S. Kindy and P.R. Oeltgen, 2008. Delta2 specific opioid receptor agonist and hibernating woodchuck plasma fraction provide ischemic neuroprotection. Acad. Emerg Med., 15: 250-257.
    CrossRef  |  

  37. El-Amouri, S.S., H. Zhu, J. Yu, F.H. Gage, I.M. Verma and M.S. Kindy, 2008. Neprilysin: An enzyme candidate to slow the progression of Alzheimer's disease. Am. J. Pathol., 172: 1342-1354.
    Direct Link  |  

  38. Chudakova, D.A., Y.H. Zeidan, B.W. Wheeler, J. Yu and S.A. Novgorodov et al., 2008. Integrin-associated Lyn kinase promotes cell survival by suppressing acid sphingomyelinase activity. J. Biol. Chem., 283: 28806-28816.
    CrossRef  |  

  39. Chi, L.Y., J. Yu, H. Zhu, X.G. Li, S.G. Zhu and M.S. Kindy, 2008. The dual role of tumor necrosis factor-alpha in the pathophysiology of spinal cord injury. Neurosci. Lett., 438: 174-179.
    CrossRef  |  

  40. Yu, J., S.A. Novgorodov, D. Chudakova, H. Zhu and A. Bielawska et al., 2007. JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction. J. Biol. Chem., 282: 25940-25949.
    CrossRef  |  

  41. Yu, J., M.S. Kindy and S. Gattoni-Celli, 2007. Semi-allogeneic vaccine for T-cell lymphoma. J. Trans. Med., Vol. 5. 10.1186/1479-5876-5-39.
    CrossRef  |  

  42. Suzuki, S., L.M. Gerhold, M. Bottner, S.W. Rau and C. Dela Cruz et al., 2007. Estradiol enhances neurogenesis following ischemic stroke through estrogen receptors α and β. J. Comp. Neurol., 500: 1064-1075.
    CrossRef  |  

  43. Mancia, A., M.L. Lundqvist, T.A. Romano, M.M. Peden-Adams and P.A. Fair et al., 2007. A dolphin peripheral blood leukocyte cDNA microarray for studies of immune function and stress reactions. Dev. Comp. Immunol., 31: 520-529.
    CrossRef  |  

  44. Hook, V., M. Kindy and G. Hook, 2007. Cysteine protease inhibitors effectively reduce in vivo levels of brain beta-amyloid related to Alzheimer's disease. Biol. Chem., 388: 247-252.
    PubMed  |  

  45. Hook, G., V.Y. Hook and M. Kindy, 2007. Cysteine protease inhibitors reduce brain beta-amyloid and beta-secretase activity in vivo and are potential Alzheimer's disease therapeutics. Biol. Chem., 388: 979-983.
    PubMed  |  

  46. El-Amouri, S.S., H. Zhu, J. Yu, F.H. Gage, I.M. Verma and M.S. Kindy, 2007. Neprilysin protects neurons against Aβ peptide toxicity. Brain Res., 1152: 191-200.
    CrossRef  |  

  47. Fanti, P., M.S. Kindy, S. Mohapatra, J. Klein, G. Colombo and H.H. Malluche, 2006. Dose-dependent effects of aluminum on osteocalcin synthesis in osteoblast-like ROS 17/2 cells in culture. Am. J. Physiol. Endocrinol. Metab., 263: E1113-E1118.
    Direct Link  |  

  48. Dubal, D.B., S.W. Rau, P.J. Shughrue, H. Zhu and J. Yu et al., 2006. Differential modulation of estrogen receptors (ERs) in ischemic brain injury: A role for ER alpha in estradiol-mediated protection against delayed cell death. Endocrinology, 147: 3076-3084.
    PubMed  |  

  49. Atkinson, C., H. Zhou, F. Qiao, J. Varela and J. Yu et al., 2006. Complement dependent P-selectin expression and injury following ischemic stroke. J. Immunol., 177: 7266-7274.
    PubMed  |  

  50. Zhang, L., J. Yu and M. Kindy, 2005. Does knockout of JNK3 gene provide a protective action in spinal cord injury of mice? Int. J. Emergency Critical Care Med., 2: 497-503.

  51. Yu, J., M.S. Kindy, B.C. Ellis, J.E. Baatz and M. Peden-Adams et al., 2005. Establishment of epidermal cell lines derived from the skin of the atlantic bottlenose dolphin (Tursiops Truncatus). Anat Rec A Discov Mol. Cell Evol. Biol., 287: 1246-1255.
    CrossRef  |  

  52. Ertekin-Taner, N., J. Ronald, L. Feuk, J. Prince and M. Tucker et al., 2005. Elevated amyloid {beta} protein (A{beta}42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene. Human Mol. Genet., 14: 447-460.
    PubMed  |  

  53. Wang, Y., A. Meng, H. Lang, S.A. Brown and J.L. Konopa et al., 2004. Activation of nuclear factor kappaB In vivo selectively protects the murine small intestine against ionizing radiation-induced damage. Cancer Res., 64: 6240-6246.
    PubMed  |  

  54. Sambamurti, K., A.C. Granholm, M.S. Kindy, N.R. Bhat, N.H. Greig, D.K. Lahiri and J.E. Mintzer, 2004. Cholesterol and Alzheimer's disease: Clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors. Curr. Drug Targets, 5: 517-528.
    PubMed  |  

  55. Marr, R.A., H. Guan, E. Rockenstein, M. Kindy and F.H. Gage et al., 2004. Neprilysin regulates amyloid β peptide levels. J. Mol. Neurosci., 22: 5-11.
    CrossRef  |  

  56. Ellsworth, J.L., R. Garcia, J. Yu and M.S. Kindy, 2004. Time window of fibroblast growth factor-18-mediated neuroprotection after occlusion of the middle cerebral artery in rats. J. Cerebral Blood Flow Metab., 24: 114-123.
    CrossRef  |  Direct Link  |  

  57. Arancio, O., H.P. Zhang, X. Chen, C. Lin and F. Trinchese et al., 2004. RAGE potentiates Aβ-induced perturbation of neuronal function in transgenic mice. EMBO J., 23: 4096-4105.
    Direct Link  |  

  58. Wu, J., B.B. Zhu, J. Yu, H. Zhu and L. Qiu et al., 2003. In vitro and in vivo modulations of benzo [c] phenanthrene-DNA adducts by DNA mismatch repair system. Nucleic Acids Res., 31: 6428-6434.
    CrossRef  |  Direct Link  |  

  59. Marr, R.A., E. Rockenstein, A. Mukherjee, M.S. Kindy and L.B. Hersh et al., 2003. Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. J. Neurosci., 23: 1992-1996.
    Direct Link  |  

  60. Hunter, C.L., O. Isacson, M. Nelson, H. Bimonte-Nelson and H. Seo et al., 2003. Regional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down's syndrome. Neurosci. Res., 45: 437-445.
    CrossRef  |  

  61. Ellsworth, J.L., R. Garcia, J. Yu and M.S. Kindy, 2003. Fibroblast growth factor-18 reduced infarct volumes and behavioral deficits after transient occlusion of the middle cerebral artery in rats. Stroke, 34: 1507-1512.
    CrossRef  |  Direct Link  |  

  62. Deane, R., S. Du Yan, R.K. Submamaryan, B. LaRue and S. Jovanovic et al., 2003. RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain. Nat. Med., 9: 907-913.
    CrossRef  |  Direct Link  |  

  63. Webb, N.R., M.C. de Beer, J. Yu, M.S. Kindy, A. Daugherty, D.R. van der Westhuyzen and F.C. de Beer, 2002. Overexpression of SR-BI by adenoviral vector promotes clearance of apoA-I, but not apoB, in human apoB transgenic mice. J. Lipid Res., 43: 1421-1428.
    CrossRef  |  Direct Link  |  

  64. Webb, N.R., L. Cai, K.S. Ziemba, J. Yu, M.S. Kindy, D.R. van der Westhuyzen and F.C. de Beer, 2002. The fate of HDL particles in vivo after SR-BI-mediated selective lipid uptake. J. Lipid Res., 43: 1890-1898.
    CrossRef  |  

  65. Smith, C.D., A.H. Andersen, R.J. Kryscio, F.A. Schmitt, M.S. Kindy, L.X. Blonder and M.J. Avison, 2002. Women at risk for AD show increased parietal activation during a fluency task. Neurology, 58: 1197-1202.
    CrossRef  |  

  66. Rebeck, G.W., M. Kindy and M.J. LaDu, 2002. Apolipoprotein E and Alzheimer's disease: The protective effects of ApoE2 and E3. J. Alzheimer's Dis., 4: 145-154.
    Direct Link  |  

  67. Lauderback, C.M., J. Kanski, J.M. Hackett, N. Maeda, M.S. Kindy and D.A. Butterfield, 2002. Apolipoprotein E modulates Alzheimer's Aβ (1-42)-induced oxidative damage to synaptosomes in an allele-specific manner. Brain Res., 924: 90-97.
    CrossRef  |  

  68. Guo, J.T., J. Yu, D. Grass, F.C. de Beer and M.S. Kindy, 2002. Inflammation-dependent cerebral deposition of serum amyloid a protein in a mouse model of amyloidosis. J. Neurosci., 22: 5900-5909.

  69. Estus, S., D. Borchelt, M.S. Kindy and R. Vassar, 2002. Abeta deposition is essential to AD neuropathology. J. Alzheimers Dis., 4: 133-138.
    PubMed  |  

  70. Zhu, H., J. Yu and M.S. Kindy, 2001. Inhibition of amyloidosis using low-molecular-weight heparins. Mol. Med., 7: 517-522.
    PubMed  |  

  71. Xie, C., M.A. Lovell, S. Xiong, M.S. Kindy and J.T. Guo et al., 2001. Expression of glutathione-S-transferase isozyme in the SY5Y neuroblastoma cell line increases resistance to oxidative stress. Free Radic. Biol. Med., 31: 73-81.
    CrossRef  |  

  72. Wyss-Coray, T., L. McConlogue, M. Kindy, A.M. Schmidt, S. Du Yan and D.M. Stern, 2001. Key signaling pathways regulate the biological activities and accumulation of amyloid-β. Neurobiol. Aging, 22: 967-973.
    Direct Link  |  

  73. Smith, C.D., A.H. Andersen, R.J. Kryscio, F.A. Schmitt, M.S. Kindy, L.X. Blonder and M.J. Avison, 2001. Differences in functional magnetic resonance imaging activation by category in a visual confrontation naming task. J. Neuroimaging, 11: 165-170.
    CrossRef  |  

  74. Lauderback, C.M., J.M. Hackett, J.N. Keller, S. Varadarajan and L. Szweda et al., 2001. Vulnerability of synaptosomes from ApoE knock-out mice to structural and oxidative modifications induced by Aβ(1-40):  Implications for Alzheimer's disease. Biochemistry, 40: 2548-2554.
    CrossRef  |  

  75. Ely, S., J.B. Ancsin, M.S. Kindy and R. Kisilevsky, 2001. Macrophage acyl-CoA: Cholesterol acyltransferase activity is influenced by the acute-phase apolipoprotein serum amyloid A. Amyloid, 8: 169-181.

  76. Dubal, D.B., H. Zhu, J. Yu, S.W. Rau and P.J. Shughrue et al., 2001. Estrogen receptor α, not β, is a critical link in estradiol-mediated protection against brain injury. Proc. Natl. Acad. Sci., 98: 1952-1957.
    Direct Link  |  

  77. Yu, J., J.T. Guo, H. Zhu and M.S. Kindy, 2000. Amyloid formation in the rat: Adenoviral expression of mouse serum amyloid A proteins. Amyloid, 7: 32-40.
    Direct Link  |  

  78. Yu, J., H. Zhu, J.T. Guo, F.C. de Beer and M.S. Kindy, 2000. Expression of mouse apolipoprotein SAA1. 1 in CE/J mice: Isoform-specific effects on amyloidogenesis. Lab. Invest., 80: 1797-1806.
    Direct Link  |  

  79. Yan, S.D., H. Zhu, A. Zhu, A. Golabek and B. Wolozin et al., 2000. RAGE and amyloid fibrils: Receptor-dependent signaling by beta-sheet fibrils mediates cellular stress in amyloidosis. Nat. Med., 6: 643-651.

  80. Mattson, M.P., H. Zhu, J. Yu and M.S. Kindy, 2000. Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: Involvement of perturbed calcium homeostasis. J. Neurosci., 20: 1358-1364.
    Direct Link  |  

  81. Kindy, M.S., M.C. de Beer, J. Yu and F.C. de Beer, 2000. Expression of mouse acute-phase (SAA1. 1) and constitutive (SAA4) serum amyloid A isotypes influence on lipoprotein profiles. Arteriosclerosis Thrombosis Vasc. Biol., 20: 1543-1550.
    Direct Link  |  

  82. Keller, J.N., K.B. Hanni and M.S. Kindy, 2000. Oxidized high-density lipoprotein induces neuron death. Exp. Neurol., 161: 621-630.
    CrossRef  |  

  83. Keller, J.N., F.F. Huang, H. Zhu, J. Yu, Y.S. Ho and M.S. Kindy, 2000. Oxidative stress-associated impairment of proteasome activity during ischemia-reperfusion injury. J. Cerebral Blood Flow Metab., 20: 1467-1473.
    CrossRef  |  

  84. Keller, J.N., C.M. Lauderback, D.A. Butterfield, M.S. Kindy, J. Yu and W.R. Markesbery, 2000. Potential role for apolipoprotein E in maintaining synaptic homeostasis. J. Neurochem., 74: 1579-1586.

  85. Guo, Z., M.S. Kindy, I. Kruman and M.P. Mattson, 2000. ALS-linked Cu/Zn-SOD mutation impairs cerebral synaptic glucose and glutamate transport and exacerbates ischemic brain injury. J. Cerebral Blood Flow Metab., 20: 463-468.
    CrossRef  |  

  86. De Villiers, W.J., G.W. Varilek, F.C. de Beer, J.T. Guo and M.S. Kindy, 2000. Increased serum amyloid a levels reflect colitis severity and precede amyloid formation in IL-2 knockout mice. Cytokine, 12: 1337-1347.
    CrossRef  |  

  87. Yu, Z., D. Zhou, A.J. Bruce-Keller, M.S. Kindy and M.P. Mattson, 1999. Lack of the p50 subunit of nuclear factor-kappaB increases the vulnerability of hippocampal neurons to excitotoxic injury. J. Neurosci., 19: 8856-8865.

  88. Smith, C.D., A.H. Andersen, R.J. Kryscio, F.A. Schmitt, M.S. Kindy, L.X. Blonder and M.J. Avison, 1999. Altered brain activation in cognitively intact individuals at high risk for Alzheimer's disease. Neurology, 53: 1391-1396.

  89. Rao, A.M., J.F. Hatcher, M.S. Kindy and R.J. Dempsey, 1999. Arachidonic acid and leukotriene C4: Role in transient cerebral ischemia of gerbils. Neurochem. Res., 24: 1225-1232.
    CrossRef  |  

  90. Kindy, M.S., J. Yu, J.T. Guo and H. Zhu, 1999. Apolipoprotein serum amyloid A in Alzheimer's disease. J. Alzheimer Dis., 1: 155-167.

  91. Keller, J.N., K.B. Hanni, S.P. Gabbita, V. Friebe, M.P. Mattson and M.S. Kindy, 1999. Oxidized lipoproteins increase reactive oxygen species formation in microglia and astrocyte cell lines. Brain Res., 830: 10-15.
    CrossRef  |  

  92. Ramanathan, S., J.C. Lewis, M.S. Kindy and S. Daunert, 1998. Heterogeneous bioluminescence binding assay for an octapeptide using recmobinant aequorin. Anal. Chim. Acta, 369: 181-188.

  93. Mayeux, R., A.M. Saunders, S. Shea, S. Mirra and D. Evans et al., 1998. Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. N. Engl. J. Med., 338: 506-511.
    CrossRef  |  

  94. Kirschner, D.A., R. Elliott-Bryant, K.E. Szumowski, W.A. Gonnerman, M.S. Kindy, J.D. Sipe and E.S. Cathcart, 1998. In vitro amyloid fibril formation by synthetic peptides corresponding to the amino terminus of apoSAA isoforms from amyloid-susceptible and amyloid-resistant mice. J. Struct. Biol., 124: 88-98.
    CrossRef  |  

  95. Kindy, M.S., A.R. King, J. Yu, C. Gerardot, J. Whitley and F.C. De Beer, 1998. Adenoviral expression of murine serum amyloid a proteins to study amyloid fibrillogenesis. Biochem. J., 332: 721-728.
    Direct Link  |  

  96. Kindy, M.S. and D.J. Rader, 1998. Reduction in amyloid a amyloid formation in apolipoprotein-E-deficient mice. Am. J. Pathol., 152: 1387-1395.
    Direct Link  |  

  97. Houdi, A.A., R. Dasgupta and M.S. Kindy, 1998. Effect of nicotine use and withdrawal on brain preproenkephalin A mRNA. Brain Res., 799: 257-263.
    CrossRef  |  

  98. Gary, D.S., A.J. Bruce-Keller, M.S. Kindy and M.P. Mattson, 1998. Ischemic and excitotoxic brain injury is enhanced in mice lacking the p55 tumor necrosis factor receptor. J. Cerebral Blood Flow Metab., 18: 1283-1287.
    CrossRef  |  

  99. Webb, N.R., M.C. De Beer, D.R. Van der Westhuyzen, M.S. Kindy and C.L. Banka et al., 1997. Adenoviral vector-mediated overexpression of serum amyloid A in apoA-I-deficient mice. J. Lipid Res., 38: 1583-1590.
    Direct Link  |  

  100. Adibhatla, R.M., M.K. Baskaya, M.S. Kindy, M. Maley and R.J. Dempsey, 1997. Beneficial effects of Sadenosyl-L-methionine on blood-brain barrier breakdown and neuronal survival after transient cerebral ischemia in gerbils. Mol. Brain Res., 44: 134-138.

  101. Soto, C., M.S. Kindy, M. Baumann and B. Frangione, 1996. Inhibition of Alzheimer's amyloidosis by peptides that prevent beta-sheet conformation. Biochem. Biophys. Res. Commun., 226: 672-680.

  102. Holtz, M.L., M.S. Kindy, S. Craddock, R.W. Moore and L.C. Pettigrew, 1996. Induction of PGH synthase and c-fos mRNA during early reperfusion of ischemic rat brain. Mol. Brain Res., 35: 339-343.
    CrossRef  |  

  103. De Beer, M.C., F.C. de Beer, C.J. Gerardot, D.R. Cecil, N.R. Webb, M.L. Goodson and M.S. Kindy, 1996. Structure of the mouse Saa4 gene and its linkage to the serum amyloid a gene family. Genomics, 34: 139-142.
    CrossRef  |  

  104. Bruce, A.J., W. Boling, M.S. Kindy, J. Peschon and P.J. Kraemer et al., 1996. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat. Med., 2: 788-794.
    CrossRef  |  

  105. Kindy, M.S., F.C. De Beer, W.R. Marksbery, M. Pras and E. Pras et al., 1995. Apolipoprotein E isotypes in systemic amyloidoses. Amyloid, 2: 159-162.

  106. Kindy, M.S., A.R. King, G. Perry, M.C. de Beer, F.C. de Beer, 1995. Association of apolipoprotein E with murine AA amyloid. Lab. Invest., 73: 469-475.

  107. De Beer, M.C., T. Yuan, M.S. Kindy, B.F. Asztalos, P.S. Roheim and F.C. De Beer, 1995. Characterization of constitutive human serum amyloid A protein (SAA4) as an apolipoprotein. J. Lipid Res., 36: 526-534.
    Direct Link  |  

  108. Banka, C.L., T. Yuan, M.C. De Beer, M.S. Kindy, L.K. Curtiss and F.C. De Beer, 1995. Serum amyloid A (SAA): Influence on HDL-mediated cellular cholesterol efflux. J. Lipid Res., 36: 1058-1065.
    Direct Link  |  

  109. Liao, F., A.J. Lusis, J.A. Berliner, A.M. Fogelman, M. Kindy, M.C. de Beer and F.C. de Beer, 1994. Serum amyloid A protein family. Differential induction by oxidized lipids in mouse strains. Arteriosclerosis Thromb. Vasc. Biol., 14: 1475-1479.
    CrossRef  |  

  110. Kindy, M.S., Y. Hu and R.J. Dempsey, 1994. Blockade of ornithine decarboxylase enzyme protects against ischemic brain damage. J. Cerebral Blood Flow Metab., 14: 1040-1045.
    CrossRef  |  

  111. Kindy, M.S., 1994. NMDA receptor inhibition using antisense oligonucleotides prevents delayed neuronal death in gerbil hippocampus following cerebral-ischemia. Neurosci. Res. Commun., 14: 175-183.

  112. Garner, L.K., M. Mendelson, K.M. Albers, M.S. Kindy and B.M. Davis, 1994. The effects of activity on enkephalin and substance P mRNA in the developing chick spinal cord. J. Comp. Neurol., 347: 36-46.

  113. De Beer, M.C., M.S. Kindy, W.S. Lane and F.C. De Beer, 1994. Mouse serum amyloid a protein (SAA5) structure and expression. J. Biol. Chem., 269: 4661-4667.
    Direct Link  |  

  114. Witkowski, A., S. Daunert, M.S. Kindy and L.G. Bachas, 1993. Enzyme-linked immunosorbent assay for an octapeptide based on a genetically engineered fusion protein. Anal. Chem., 65: 1147-1151.
    CrossRef  |  

  115. Osborne, J.G., M.S. Kindy, B.A. Spruce and K.F. Hauser, 1993. Ontogeny of proenkephalin mRNA and enkephalin peptide expression in the cerebellar cortex of the rat: spatial and temporal patterns of expression follow maturational gradients in the external granular layer and in Purkinje cells. Dev. Brain Res., 76: 1-12.
    CrossRef  |  

  116. Mann, J.S., M.S. Kindy, J.F. Hyde, M.R. Clark and T.E. Curry, 1993. Role of protein synthesis, prostaglandins and estrogen in rat ovarian metalloproteinase inhibitor production. Biol. Reprod., 48: 1006-1013.
    CrossRef  |  

  117. Kindy, M.S., 1993. Inhibition of tyrosine phosphorylation prevents delayed neuronal death following cerebral ischemia. J. Cerebral Blood Flow Metab., 13: 372-377.
    CrossRef  |  

  118. De Beer, M.C., F.C. De Beer, W.D. McCubbin, C.M. Kay and M.S. Kindy, 1993. Structural prerequisites for amyloid fibril formation: A novel mouse model. J. Biol. Chem., 268: 20606-20612.

  119. Kindy, M.S., A.N. Bhat and N.R. Bhat, 1992. Transient ischemia stimulates glial fibrillary acid protein and vimentin gene expression in the gerbil neocortex, striatum and hippocampus. Mol. Brain Res., 13: 199-206.
    CrossRef  |  

  120. Hiestand, D.M. and M.S. Kindy, 1992. Calcium/calmodulin dependent protein kinase II mRNA in the gerbil brain after cerebral ischemia. Neurosci. Lett., 144: 75-78.
    CrossRef  |  

  121. Heistand, D., B. Haley and M.S. Kindy, 1992. Phosphorylation changes following transient ischemia in the gerbil brain. J. Neurol. Sci., 113: 31-37.

  122. Combs, D.J., R.J. Dempsey, D. Donaldson and M.S. Kindy, 1992. Hyperglycemia suppresses c-fos mRNA expression following transient cerebral ischemia in gerbils. J. Cerebral Blood Flow Metab., 12: 169-172.
    CrossRef  |  

  123. Campos-Gonzalez, R. and M.S. Kindy, 1992. Tyrosine phosphorylation of microtubule‐associated protein kinase after transient ischemia in the gerbil brain. J. Neurochem., 59: 1955-1958.
    CrossRef  |  

  124. Brown, K.E., M.S. Kindy and G.E. Sonenshein, 1992. Expression of the c-myb proto-oncogene in bovine vascular smooth muscle cells. J. Biol. Chem., 267: 4625-4630.
    Direct Link  |  

  125. Bhat, N.R., K.F. Hauser and M.S. Kindy, 1992. Cell proliferation and protooncogene induction in oligodendroglial progenitors. J. Neurosci. Res., 32: 340-349.
    CrossRef  |  

  126. Osborne, J.G., M.S. Kindy and K.F. Hauser, 1991. Expression of proenkephalin mRNA in developing cerebellar cortex of the rat: Expression levels coincide with maturational gradients in Purkinje cells. Dev. Brain Res., 63: 63-69.
    CrossRef  |  

  127. Marterre Jr., W.F., M.S. Kindy, J.M. Carney, R.W. Landrum and W.E. Strodel, 1991. Induction of the protooncogene c-fos and recovery of cytosolic adenosine triphosphate in reperfused liver after transient warm ischemia: Effect of nitrone free-radical spin-trap agents. Surgery, 110: 184-191.
    PubMed  |  

  128. Mann, J.S., M.S. Kindy, D.R. Edwards and T.E. Curry, 1991. Hormonal regulation of matrix metalloproteinase inhibitors in rat granulosa cells and ovaries. Endocrinology, 128: 1825-1832.
    CrossRef  |  Direct Link  |  

  129. Kindy, M.S., M. Srivatsan and B. Peretz, 1991. Age-related differential expression of neuropeptide mRNAs in Aplysia. Neuroreport, 2: 465-468.

  130. Kindy, M.S., K.E. Brown and G.E. Sonenshein, 1991. Regulation of expression of the growth‐state‐related genes 2F1 and 2A9 during entry of quiescent smooth muscle cells into the cell cycle. J. Cell. Biochem., 46: 345-350.
    CrossRef  |  

  131. Kindy, M.S., J.P. Carney, R.J. Dempsey and J.M. Carney, 1991. Ischemic induction of protooncogene expression in gerbil brain. J. Mol. Neurosci., 2: 217-228.
    PubMed  |  

  132. Dempsey, R.J., J.M. Carney and M.S. Kindy, 1991. Modulation of ornithine decarboxylase mRNA following transient ischemia in the gerbil brain. J. Cerebral Blood Flow Metab., 11: 979-985.
    CrossRef  |  

  133. Carney, J.M., J.P. Carney, B. Tolliver and M.S. Kindy, 1991. Selective effects of methamphetamine on mRNA expression and behavior in gerbils. J. Neuropharm., 30: 1011-1019.

  134. Kindy, M.S. and I.M. Verma, 1990. Developmental expression of the Xenopus laevis fos protooncogene. Cell Growth Differ., 1: 27-37.
    PubMed  |  

  135. Dempsey, R.J., J.M. Carney and M.S. Kindy, 1990. Inducible ornithine decarboxylase expression in brain subject to vasogenic oedema after transient ischaemia: Relationship to C-fos gene expression. Acta Neurochirurgica Supplementum, 51: 189-191.
    PubMed  |  

  136. Reilly, C.F., M.S. Kindy, K.E. Brown, R.D. Rosenberg and G.E. Sonenshein, 1989. Heparin prevents vascular smooth muscle cell progression through the G1 phase of the cell cycle. J. Biol. Chem., 264: 6990-6995.
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  137. Glenney, J.R., M.S. Kindy and L. Zokas, 1989. Isolation of a new member of the S100 protein family: Amino acid sequence, tissue and subcellular distribution. J. Cell Biol., 108: 569-578.
    CrossRef  |  

  138. Kindy, M.S., C.J. Chang and G.E. Sonenshein, 1988. Serum deprivation of vascular smooth muscle cells enhances collagen gene expression. J. Biol. Chem., 263: 11426-11430.
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  139. Kindy, M.S., J.E. McCormack, A.J. Buckler, R.A. Levine and G.E. Sonenshein, 1987. Independent regulation of transcription of the two strands of the c-myc gene. Mol. Cell. Biol., 7: 2857-2862.
    CrossRef  |  Direct Link  |  

  140. Stepp, M.A., M.S. Kindy, C. Franzblau and G.E. Sonenshein, 1986. Complex regulation of collagen gene expression in cultured bovine aortic smooth muscle cells. J. Biol. Chem., 261: 6542-6547.
    Direct Link  |  

  141. Kindy, M.S. and G.E. Sonenshein, 1986. Regulation of oncogene expression in cultured aortic smooth muscle cells: Post-transcriptional control of c-myc mRNA. J. Biol. Chem., 261: 12865-12868.
    Direct Link  |  

  142. Dean, M., R.A. Levine, W. Ran, M.S. Kindy, G.E. Sonenshein and J. Campisi, 1986. Regulation OFC-MYC transcription and mRNA abundance by serum growth factors and cell contact. J. Biol. Chem., 261: 9161-9166.

  143. Stepp, M.A., M. Kindy, C. Franzblau and G. Sonenshein, 1985. Cloning of type III collagen and expression in aortic smooth muscle cells. Ann. N. Y. Acad. of Sci., 460: 510-513.
    CrossRef  |