Dr. Howard Grant Shertzer

Dr. Howard Grant Shertzer

Professor
University of Cincinnati Medical Center, USA


Highest Degree
Ph.D. in Cell Biology from University of California, USA

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Area of Interest:

Molecular Sciences
100%
Oxidative Stress
62%
Inflammation
90%
Obesity
75%
Fatty Liver Disease
55%

Selected Publications

  1. Tobia, C.M., H.G. Shertzer and K.J. Pearson, 2013. Dietary whey protein protects mice from high fat diet-induced liver damage. Lipids Health Dis. .

  2. Shertzer, H.G., M. Krishan and M.B. Genter, 2013. Dietary whey protein stimulates mitochondrial activity and decreases oxidative stress in mouse female brain. Neurosci. Lett., 548: 159-164.
    CrossRef  |  PubMed  |  

  3. Krishan, M., H.G. Shertzer and M.B. Genter, 2013. Enhanced delivery of intranasally administered gemcitabine to the central nervous system. Fund. Clin. Pharmacol. .

  4. Dong, H., H.G. Shertzer, M.B. Genter, F.J. Gonzalez and V. Vasiliou et al., 2013. Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins. Biochem. Biophys. Res. Commun., 435: 727-732.
    CrossRef  |  PubMed  |  

  5. Chen, Y., H. Dong, D.C. Thompson, H.G. Shertzer, D.W. Nebert and V. Vasiliou, 2013. Glutathione defense mechanism in liver injury: Insights from animal models. Food Chem. Toxicol., 60: 38-44.
    CrossRef  |  PubMed  |  Direct Link  |  

  6. Woods, S.E., M.B. Genter and H.G. Shertzer, 2012. A comparison of the effectiveness of metformin and acetaminophen in preventing olanzapine toxicity in mice. Pharmacologia, 3: 233-238.
    Direct Link  |  

  7. Thompson, C.M., D.M. Proctor, M. Suh, L.C. Haws and C.D. Hebert et al., 2012. Comparison of the effects of hexavalent chromium in the alimentary canal of F344 rats and B6C3F1 mice following exposure in drinking water: Implications for carcinogenic modes of action. Toxicol. Sci., 125: 79-90.
    CrossRef  |  PubMed  |  

  8. Genter, M.B., N.C. Newman, H.G. Shertzer, B. Bolon and S.F. Ali, 2012. Distribution and systemic effects of intranasally administered 25 nm silver nanoparticles in adult mice. Toxicol. Pathol., 40: 1004-1013.
    PubMed  |  

  9. Chen, Y., M. Krishan, D.W. Nebert, H.G. Shertzer, 2012. Glutathione-deficient mice are susceptible to TCDD-Induced hepatocellular toxicity but resistant to steatosis. Chem. Res. Toxicol., 25: 94-100.
    CrossRef  |  PubMed  |  

  10. Thompson, C.M., D.M. Proctor, L.C. Haws, C. Hebert and S. Grimes et al., 2011. The oral toxicity of hexavalent chromium in B6C3F1 mice: A potential role of oxidative stress in intestinal cytotoxicity. Toxicol. Sci. .

  11. Shertzer, H.G., S.E. Woods, M. Krishan, M.B. Genter and K.J. Pearson, 2011. Dietary whey protein prevents high fat diet-induced changes in energy balance in mice. J. Nutr., 141: 1-6.

  12. Kendig, E.L., Y. Chen, M. Krishan, E. Johansson and S.N. Schneider et al., 2011. Lipid metabolism and body composition in Gclm(-/-) mice. Toxicol. Applied Pharmacol., 257: 338-348.
    CrossRef  |  PubMed  |  

  13. Shertzer, H.G., E.L. Kendig, H.A. Nasrallah, E. Johansson and M.B. Genter, 2010. Protection from olanzapine-induced metabolic toxicity in mice by acetaminophen and tetrahydroindenoindole. Int. J. Obesity, 34: 970-979.
    CrossRef  |  PubMed  |  Direct Link  |  

  14. Shertzer, H.G., 2010. Protective effects of the antioxidant 4b,5,9b,10-tetrahydroindeno[1,2-b]indole against TCDD toxicity in C57BL/6J mice. Int. J. Toxicol., 29: 40-48.
    CrossRef  |  PubMed  |  

  15. Peng, Z., E. Geh, L. Chen, Q. Meng and Y. Fan et al., 2010. IkB kinase β regulates redox homeostasis by controlling the constitutive levels of glutathione. Mol. Pharmacol., 77: 784-792.

  16. Johansson, E., S.C. Wesselkamper, H.G. Shertzer, G.D. Leikauf, D.W. Nebert, T.P. Dalton and Y. Chen, 2010. Glutathione deficient C57BL/6J mice are not sensitized to ozone-induced lung injury. Biochem. Biophys. Res. Commun., 396: 407-412.
    CrossRef  |  PubMed  |  

  17. Chen, Y., Y. Yang, M.L. Miller, D.X. Shen and E. Johansson et al., 2010. N-Acetylcysteine-treated hepatocyte-specific Gclc knockout mice: Progression from steatosis to hepatic cirrhosis. J. Hepatol. .

  18. Shertzer, H.G., S.N. Schneider, E.L. Kendig, D.J. Clegg, D.A. D'Alessio, E. Johansson and M.B. Genter, 2009. Tetrahydroindenoindole inhibits the progression of diabetes in mice. Chem. Biol. Interact., 177: 71-80.
    CrossRef  |  PubMed  |  Direct Link  |  

  19. Eismann, T., N. Huber, T. Shin, S. Kuboki and E. Galloway et al., 2009. Peroxiredoxin-6 protects against mitochondrial dysfunction and liver injury during ischemia-reperfusion in mice. Am. J. Physiol. Gastrointest. Liver Physiol., 296: G266-G274.
    PubMed  |  

  20. Dong, H., T.P. Dalton, M.L. Miller, Y. Chen and S. Bansal et al., 2009. Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1: Differing responses to dietary benzo[a]pyrene as proof of principle. Mol. Pharm., 75: 555-567.
    CrossRef  |  PubMed  |  

  21. Chen, Y., E. Johansson, Y. Fan, H.G. Shertzer, V. Vasiliou, D.W. Nebert and T.P. Dalton, 2009. Early onset senescence occurs when fibroblasts lack glutamate cysteine ligase modifier subunit. Free Radic. Biol. Med., 47: 410-418.
    CrossRef  |  PubMed  |  

  22. Shertzer, H.G., S.N. Schneider, E.L. Kendig, D.J. Clegg, D.A. D'Alessio and M.B. Genter, 2008. Acetaminophen normalizes glucose homeostasis in mouse models for diabetes. Biochem. Pharmacol., 75: 1402-1410.
    CrossRef  |  PubMed  |  Direct Link  |  

  23. Kendig, E.L., S.N. Schneider, D.J. Clegg, M.B. Genter and H.G. Shertzer, 2008. Over-the-counter analgesics normalize blood glucose and body composition in mice fed a high fat diet. Biochem. Pharmacol., 76: 216-224.
    CrossRef  |  PubMed  |  Direct Link  |  

  24. Yang, Y., Y. Chen, E. Johansson, S.N. Schneider, H.G. Shertzer, D.W. Nebert and T.P. Dalton, 2007. Interaction between the catalytic and modifier subunits of glutamate-cysteine ligase. Biochem. Pharmacol., 74: 372-381.
    PubMed  |  

  25. Shertzer, H.G., M.B. Genter, G. Talaska, C.P. Curran, D.W. Nebert and T.P. Dalton, 2007. 7H-Dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes. Carcinogenesis, 28: 1371-1378.
    PubMed  |  

  26. Peng, Z., L. Peng, Y. Fan, E. Zandi, H.G. Shertzer and Y. Xia, 2007. A critical role for IκKβ in metallothionein-1 expression and protection against arsenic toxicity. J. Biol. Chem., 282: 21487-21496.

  27. Chen, Y., Y. Yang, M.L. Miller, D.X. Shen and H.G. Shertzer et al., 2007. Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure. Hepatology, 45: 1118-1128.
    CrossRef  |  PubMed  |  

  28. Uno, S., T.P. Dalton, N. Dragin, C.P. Curran and S. Derkenne et al., 2006. Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate. Mol. Pharmacol., 69: 1103-1114.
    PubMed  |  

  29. Shertzer, H.G., M.B. Genter, D.X. Shen, D.W. Nebert, Y. Chen and T.P. Dalton, 2006. TCDD decreases ATP levels and increases reactive oxygen production through changes in mitochondrial F0F1-ATP synthase and ubiquinone. Toxicol. Appllied Pharmacol., 217: 363-374.

  30. Genter, M.B., C.D. Clay, T.P. Dalton, H.B. Dong, D.W. Nebert and H.G. Shertzer, 2006. Comparison of mouse hepatic mitochondrial versus microsomal cytochromes P450 following TCDD treatment. Biochem. Biophys. Res. Commun., 342: 1375-1381.
    PubMed  |  

  31. Dragin, N., T.P. Dalton, M.L. Miller, H.G. Shertzer and D.W. Nebert, 2006. For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential. J. Biol. Chem., 281: 18591-18600.
    PubMed  |  

  32. Curran, C.P., K.A. Miller, T.P. Dalton, C.V. Vorhees, M.L. Miller, H.G. Shertzer and D.W. Nebert, 2006. Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl. Toxicol. Sci., 89: 454-464.
    PubMed  |  

  33. Shen, D.X., T.P. Dalton, D.W. Nebert and H.G. Shertzer, 2005. Glutathione redox state regulates mitochondrial reactive oxygen production. J. Biol. Chem., 280: 25305-25312.
    PubMed  |  

  34. Reichard, J.F., T.P. Dalton, H.G. Shertzer and A. Puga, 2005. Induction of oxidative stress responses by dioxin and other ligands of the aryl hydrocarbon receptor. Dose-Response, 3: 306-331.
    CrossRef  |  PubMed  |  

  35. Kann, S., C. Estes, J.F. Reichard, M.Y. Huang and M.A. Sartor et al., 2005. Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status. Toxicol. Sci., 87: 365-384.
    PubMed  |  

  36. Kadekaro, A.L., H. Kanto, R. Kavanagh, S. Schwemberger and J. Cornelius et al., 2005. α-Melanocortin and endothelin-1 promote the survival of human melanocytes by activating anti-apoptotic pathways and enhancing the repair of DNA photoproducts. Cancer Res., 65: 4292-4299.
    CrossRef  |  Direct Link  |  

  37. Jiang, Z., T.P. Dalton, L. Jin, B. Wang and Y. Tsuneoka et al., 2005. Toward the evaluation of function in genetic variability: Characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus. Hum. Mutat., 25: 196-206.
    PubMed  |  

  38. Deshmukh, H.S., L.M. Case, S.C. Wesselkamper, M.T. Borchers and L.D. Martin et al., 2005. Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation. Am. J. Respir. Crit. Care Med., 171: 305-314.
    CrossRef  |  Direct Link  |  

  39. Chen, Y., H.G. Shertzer, S.N. Schneider, D.W. Nebert and T.P. Dalton, 2005. Glutamate cysteine ligase catalysis: Dependence on ATP and modifier subunit for regulation of tissue glutathione levels. J. Biol. Chem., 280: 33766-33774.
    PubMed  |  

  40. Uno, S., T.P. Dalton, S. Derkenne, C.P. Curran, M.L. Miller, H.G. Shertzer and D.W. Nebert, 2004. Oral exposure to benzo[a]pyrene in the mouse: Detoxication by inducible cytochrome P450 is more important than metabolic activation. Mol. Pharmacol., 65: 1225-1237.
    PubMed  |  

  41. Uno, S., T.P. Dalton, P. Sinclair, N. Gorman and B. Wang et al., 2004. Cyp1a1(-/-) male mice: Protection against high-dose TCDD-induced lethality and wasting syndrome and resistance to intrahepatocyte lipid accumulation and uroporphyria. Toxicol. Applied Pharmacol., 196: 410-421.
    PubMed  |  

  42. Uno, S., B. Wang, H.G. Shertzer, D.W. Nebert and T.P. Dalton, 2004. Balancer-Cre transgenic mouse germ cells direct the incomplete resolution of a tri-loxP-targeted Cyp1a1 allele, producing a conditional knockout allele. Biochem. Biophys. Res. Commun., 312: 494-499.
    PubMed  |  

  43. Shertzer, H.G., C.D. Clay, M.B. Genter, S.N. Schneider, D.W. Nebert and T.P. Dalton, 2004. CYP1A2 protects against reactive oxygen production in mouse liver microsomes. Free Radic. Biol. Med., 36: 605-617.
    PubMed  |  

  44. Shertzer, H.G., C.D. Clay, M.B. Genter, M.C. Chames and S.N. Schneider et al., 2004. Uncoupling-Mediated generation of reactive oxygen by halogenated aromatic hydrocarbons in mouse liver microsomes. Free Radic. Biol. Med., 36: 618-631.
    PubMed  |  

  45. Derkenne, S., C.P. Curran, T.P. Dalton, H.G. Shertzer and D.W. Nebert, 2004. Theophylline pharmacokinetics: Comparison of Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene and Cyp1 (+/+) wild-type mice. Pharmacogenet. Genomics, 15: 503-511.
    PubMed  |  

  46. Dalton, T.P., Y. Chen, S.N. Schneider, D.W. Nebert and H.G. Shertzer, 2004. Genetically altered mice to evaluate glutathione homeostasis in health and disease. Free Radic. Biol. Med., 37: 1511-1526.
    CrossRef  |  PubMed  |  Direct Link  |  

  47. Yang, Y., M.Z. Dieter, Y. Chen, H.G. Shertzer, D.W. Nebert and T.P. Dalton, 2003. Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response. J. Biol. Chem., 277: 49446-49452.
    PubMed  |  

  48. Tsuneoka, Y., T.P. Dalton, M.L. Miller, C.D. Clay, H.G. Shertzer, G. Talaska and D.W. Nebert, 2003. 4-aminobiphenyl-induced liver and urinary bladder DNA adduct formation in Cyp1a2(-/-) and Cyp1a2(+/+) mice. J. Natl. Cancer Inst., 95: 1227-1237.
    PubMed  |  

  49. Shertzer, H.G. and D.W. Nebert, 2003. A Toxicological Perspective on Catastrophic Injury: Environmental Arsenic. In: The Catastrophic Injury Handbook, Anchor, K.N., J.E. Shmerling and J.M. Anchor (Eds.). Chapter 23, Kendall/Hunt Publishers, Dubuque, IA., USA., pp: 280-288.

  50. Roberts, R.A., J.I. Goodman, H.G. Shertzer, T.P. Dalton and W.H. Farland, 2003. Rodent toxicity and nongenotoxic carcinogenesis: Knowledge-based human risk assessment based on molecular mechanisms. Toxicol. Mech. Methods, 13: 21-29.
    CrossRef  |  PubMed  |  

  51. Dieter, M.Z., S.L. Freshwater, H.G. Shertzer, M. Miller, T.P. Dalton and D.W. Nebert, 2003. Pharmacological rescue of the 14CoS/14CoS mouse: Hepatocyte apoptosis is likely caused by endogenous oxidative stress. Free Radic. Biol. Med., 35: 351-367.
    PubMed  |  

  52. Dalton, T.P., L. He, H.G. Shertzer and A. Puga, 2003. Redox Regulation of Gene Expression: Transcriptional Induction of Heme Oxygenase-1. In: Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles, Torres, M., J. Fukuto and H.J. Forman (Eds.). Chapter 18, Kluwer Press, Amsterdam, Netherlands, pp: 333-364.

  53. D'Souza, V.M., H.G. Shertzer, D.J. Buckley, S.P. Yadav, A.R. Buckley and G.M. Pauletti, 2003. Glucose-mediated regulation of intestinal PepT-1 in the Caco-2 cell culture model. AAPS Pharm. Sci., 5: 247-255.

  54. Burman, D.M., H.G. Shertzer, A.P. Senft, T.P. Dalton and M.B. Genter, 2003. Antioxidant perturbations in the olfactory mucosa of alachlor-treated rats. Biochem. Pharmacol., 66: 1707-1715.
    PubMed  |  

  55. Solis, W.A., T.P. Dalton, M.Z. Dieter, S. Freshwater and J.M. Harrer et al., 2002. Glutamate-cysteine ligase modifier subunit: Mouse Gclm gene structure and regulation by agents that cause oxidative stress. Biochem. Pharmacol., 63: 1739-1754.
    PubMed  |  

  56. Shertzer, H.G., T.P. Dalton, G. Talaska and D.W. Nebert, 2002. 4-Aminobiphenyl-induced methemoglobinemia: Protection by cytochrome P450 1A2 (CYP1A2). Toxicol. Appl. Pharmacol., 181: 32-37.

  57. Senft, A.P., T.P. Dalton, D.W. Nebert, M.B. Genter, R.J. Hutchinson and H.G. Shertzer, 2002. Dioxin increases reactive oxygen production in mouse liver mitochondria. Toxicol. Appl. Pharmacol., 178: 15-21.
    PubMed  |  

  58. Senft, A.P., T.P. Dalton, D.W. Nebert, M.B. Genter and A. Puga et al., 2002. Mitochondrial reactive oxygen production is dependent on the aromatic hydrocarbon receptor. Free Radic. Biol. Med., 33: 1268-1278.
    PubMed  |  

  59. Dalton, T.P., A. Puga and H.G. Shertzer, 2002. Induction of cellular oxidative stress by aryl hydrocarbon receptor activation. Chem. Biol. Interact., 141: 77-95.
    CrossRef  |  PubMed  |  Direct Link  |  

  60. Uno, S., T.P. Dalton, H.G. Shertzer, M.B. Genter, D. Warshawski, G. Talaska and D.W. Nebert, 2001. Benzo[a]pyrene-induced toxicity: Paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels. Biochem. Biophys. Res. Commun., 289: 1049-1056.
    PubMed  |  

  61. Shertzer, H.G., D.W. Nebert, A.P. Senft, M. Dingeldein, M.B. Genter and T.P. Dalton, 2001. A spectrophotometric assay for acetanilide 4-hydroxylase, an estimate for CYP1A2 enzyme activity. Toxicol. Methods, 11: 81-88.

  62. Shertzer, H.G., 2001. Organic Sulfur Compounds. In: Patty's Toxicology, Bingham, E., B. Cohrssen and C.H. Powell (Eds.). 5th Edn., Vol. 7, Chapter 94, John Wiley and Sons, Inc., New York, USA., pp: 681-765.

  63. Dumaswala, U.J., L. Zhuo, S. Mahajan, P.N.M. Nair, H.G. Shertzer, P. Dibello and D.W. Jacobsen, 2001. Glutathione protects chemokine scavenging and antioxidative defense functions in human red blood cells. Am. J. Physiol. Cell Physiol., 280: C867-C873.
    PubMed  |  

  64. Dalton, T.P., J.K. Kerzee, B. Wang, M. Miller and M.Z. Dieter et al., 2001. Dioxin exposure is an environmental risk factor for ischemic heart disease. Cardiovasc. Toxicol., 1: 285-298.
    CrossRef  |  PubMed  |  Direct Link  |  

  65. Shertzer, H.G. and A.P. Senft, 2000. The micronutrient indole-3-carbinol: Implications for disease and chemoprevention. Drug Metabol. Drug Interact., 17: 159-188.
    PubMed  |