Dr. Wael Mahmoud Kamel
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Dr. Wael Mahmoud Kamel

Assistant Professor
Department of Biochemistry, Biotechnology Research Institute, National Research Centre (NRC), Egypt

Highest Degree
Ph.D. in Biochemistry from Helwan University, Egypt

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Biography

His name is Wael Mahmoud Kamel Aboulthana. He is appointed as a researcher in Biochemistry Department, Genetic Engineering and Biotechnology Research Division, National Research Centre, Dokki, Giza, Egypt. He obtained his M.Sc. and PhD degrees in Biochemistry (Helwan University). During his M.Sc. and PhD theses, his scientific work was concerned with molecular radiation biology through studying effect of gamma irradiation on different body functions at biochemical and molecular levels and hence studying efficiency of willow leaves extract against the adverse effect of gamma irradiation. Moreover, more advanced and deeper studies were carried out through studying effect of gamma irradiation on both of male and female fertility genes and evaluation of the ameliorative effect of the most abundant phyto-constituent of willow leaves (salicin) against the deleterious effect of irradiation.
Recently, he is interesting to evaluate the phytochemical and biological efficiency of different plant extracts then selecting the most effective one. Consequently, efficiency of the selected extract will be enhanced by incorporating nanoparticles (silver and gold). Then, the nano-extract will be studied against progression of tumors induced chemically in rats as compared to healthy group. Moreover, he is looking forward to use the electrophoresis technique to identify native biomarkers and for detecting the different mutations (qualitative and quantitative) through evaluation of the natured and denatured proteins, different moieties of protein and different isoenzymes. He demonstrated as a personal investigator on the internal projects of the 11th plan entitled "Evaluation of Antioxidant Efficiency of Silver Nanoparticles Biosynthesized using Croton tiglium L. Seeds Extract against Azoxymethane Induced Colon Cancer in Rats" and the 12th plan entitled "Evaluation of the ameliorative Effect of Casuarina equisetifolia Bark Extract after Incorporating Gold Nanoparticles against Toxicity Induced by Pesticides in Rats" funded by National Research Centre.

Area of Interest:

Biomedical Sciences
100%
Pharmaceutical Science
62%
Genetic Engineering
90%
Infectious Disease
75%
Biochemistry
55%

Research Publications in Numbers

Books
8
Chapters
0
Articles
45
Abstracts
0

Selected Publications

  1. Hassan, A.S., N.M. Morsy, W.M. Aboulthana and A. Ragab, 2023. Exploring novel derivatives of isatin-based Schiff bases as multi-target agents: design, synthesis, in vitro biological evaluation, and in silico ADMET analysis with molecular modeling simulations. RSC Adv., 13: 9281-9303.
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  2. Hassan, A.S. and W.M. Aboulthana, 2023. Synthesis, in vitro biological investigation, and in silico analysis of pyrazole-based derivatives as multi-target agents. Egypt. J. Chem., 66: 441-445.
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  3. Alkahtani, H.M., A.A. Almehizia, M.A. Al-Omar, A.J. Obaidullah, A.A. Zen, A.S. Hassan and W.M. Aboulthana, 2023. In vitro evaluation and bioinformatics analysis of schiff bases bearing pyrazole scaffold as bioactive agents: Antioxidant, anti-diabetic, anti-Alzheimer, and anti-arthritic. Molecules, Vol. 28. 10.3390/molecules28207125.
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  4. Aboulthana, W., R. Bekheit and W. Serag, 2023. Bio- and phyto-chemical study on Nannochloropsis oculata algal Eextract incorporated with gold nanoparticles, in vitro study. Front. Sci. Res. Technol., 5: 1-7.
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  5. Hassan, A.S., N.M. Morsy, W.M. Aboulthana and A. Ragab, 2022. In vitro enzymatic evaluation of some pyrazolo[1,5‐a]pyrimidine derivatives: Design, synthesis, antioxidant, anti‐diabetic, anti‐Alzheimer, and anti‐arthritic activities with molecular modeling simulation. Drug Dev. Res., 10.1002/ddr.22008.
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  6. Hassan, A.M., A.O. Said, B.H. Heakal, A. Younis, W.M. Aboulthana and M.F. Mady, 2022. Green synthesis, characterization, antimicrobial and anticancer screening of new metal complexes incorporating schiff base. ACS Omega, 7: 32418-32431.
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  7. Aboulthana, W.M., N.I. Omar, E.A. Hasan, K.A. Ahmed and A.M. Youssef, 2022. Assessment of the biological activities of Egyptian Purslane (Portulaca oleracea) extract after incorporating metal nanoparticles, in vitro and in vivo study. Asian Pac. J. Cancer Prev., 23: 287-310.
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  8. Aboulthana, W.M., N. Omar, A. El-Feky, E. Hasan, N. Ibrahim and A. Youssef, 2022. In vitro study on effect of zinc oxide nanoparticles on the biological activities of Croton tiglium L. seeds extracts. Asian Pac. J. Cancer Prev., 23: 2671-2686.
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  9. Aboulthana, W.M., E. Refaat, S. Khaled, N. Ibrahim and A. Youssef, 2022. Metabolite profiling and biological activity assessment of Casuarina equisetifolia bark after incorporating gold nanoparticles. Asian Pac. J. Cancer Prev., 23: 3457-3471.
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  10. Hussein, M.A., E.S. Khalifa, S.S. Abdel-Azeem, S.H. Hussein and F.E.Y. Hassan, 2021. Assessment of different sourced water quality to be suitable for human uses. Scholars Int. J. Chem. Mater. Sci., 4: 79-88.
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  11. Deabes, M.M., W.M. Aboulthanaorcid, K.A. Ahmedorcid and K.M. Naguib, 2021. Assessment of the ameliorative effect of Bacillus subtilis against the toxicity induced by aflatoxin B1 in rats. Egypt. J. Chem., 64: 2141-2164.
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  12. Deabes, M., W. Aboulthana, E.E.undefined.D. Marzouk, M. Mohamed and K. Ahmed, 2021. Evaluation of the hepato- and neuroprotective effect of chemical constituents in saussurea costus extract against the toxicity induced by chloropyrofos ethyl in rats. Egypt. J. Chem., 10.21608/ejchem.2021.55840.3199.
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  13. Aly, H., N.A. Ibrahim, A. Matloub, A.E.K. El-Sayed, W. Aboulthana, A.S.A.S.A. Elsamiae and A.N. Singab, 2021. Phytochemical and biological studies on proteins isolated from different microalgal species. Egypt. J. Chem., 64: 6771-6786.
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  14. Aboulthana, W.M., W. Shousha, E. Essawy, M. Saleh and A. Salama, 2021. Assessment of the anti-cancer efficiency of silver Moringa oleifera leaves nano-extract against colon cancer induced chemically in rats. Asian Pac. J. Cancer Prev., 22: 3267-3286.
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  15. Aboulthana, W., A. Youssef, M. Seif, N. Osman and R. Sahu et al., 2021. Comparative study between croton tiglium seeds and Moringa oleifera leaves extracts, after incorporating silver nanoparticles, on murine brains. Egypt. J. Chem., 10.21608/ejchem.2021.53777.3113.
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  16. Youssef, A., A.El-E.H. Gad, H. Ghannam, A. Zedan, W. Aboulthana and Al-S. Al-Sherbini, 2020. Synthesis of high efficient CS/PVDC/TiO2-Au nanocomposites for photocatalytic degradation of carcinogenic ethidium bromide in sunlight. Egypt. J. Chem., 63: 5-9.
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  17. Sahu, R.K., W.M. Aboulthana and D.K. Mehta, 2020. Phyto-phospholipid complexation as a novel drug delivery system for management of cancer with better bioavailability: current perspectives and future prospects. Anti-Cancer Agents Medic. Chem., 10.2174/1871520620999201110191741.
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  18. Hassan, A.M., B. Heakal, A. Said, W. Aboulthana ans M. Abdelmoaz, 2020. Comparative study for synthesis of novel Mn (II), Co (II), Ni (II), Cu (II), Zn (II) and Zr (IV)complexes under conventional methods and microwave irradiation and evaluation of their antimicrobial and anticancer activity. Egypt. J. Chem., 0: 0-0.
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  19. Attia A.M.M., W.M. Aboulthana, G.M. Hassan and E. Aboelezz, 2020. Assessment of absorbed dose of gamma rays using the simultaneous determination of inactive hemoglobin derivatives as a biological dosimeter. Radiation and Environmental Biophysics 59: 131-144.
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  20. Attia A.M.M., W.M. Aboulthana, Abd El-Baset M. Sayed, F.A.A. Ibrahim, N.A. Abd El-Latif, S.W. Aziz, A.M. Elwan, M.D.E. Abdelmaksoud, S.A.A. Moussa, M.M.M. Elnasharty, 2020. A multi-component spectrophotometric method for simultaneous determination of total bilirubin, oxyhemoglobin, and methemalbumin in human sera. Journal of Applied Biology & Biotechnology 8: 38-46.
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  21. Aboulthana, W.M., R.K. Sahu and M.H. Saleh, 2020. Electrophoresis as an a tool for the early cancer diagnosis. Anti-Cancer Agents Medic. Chem., 10.2174/1871520620999201105163914.
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  22. Aboulthana, W.M., N.S. Ibrahim, N.M. Osman, M.M. Seif, A.K. Hassan, A.M. Youssef, A.M. El-Feky and A.A. Madboli, 2020. Evaluation of the biological efficiency of silver nanoparticles biosynthesized using Croton tiglium L. seeds extract against azoxymethane induced colon cancer in rats. Asian Pac. J. Cancer Prev., 21: 1369-1389.
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  23. Aboulthana W.M., M.K. Darwish, M.H. Halim, H.A. El-Baz and O.S. Ahmed, 2020. Biochemical and electrophoretic study for diagnosis of the disease stage in patients with asthmatic bronchitis. Bulletin of the National Research Centre 10.1186/s42269-020-00328-6 http://dx.doi.org/10.1186/s42269-020-00328-6.
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  24. Abdel-Halim A.H., A.A.A. Fyiad, W.M. Aboulthana, N.M. El-Sammad, A.M. Youssef and M.M. Ali, 2020. Assessment of the anti-diabetic effect of bauhinia variegata gold nano-extract against streptozotocin induced diabetes mellitus in rats. Journal of Applied Pharmaceutical Science 10: 77-91.
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  25. Shousha W.G., W.M. Aboulthana, A.H. Salama, M.H. Saleh and E.A. Essawy, 2019. Evaluation of the biological activity of moringa oleifera leaves extract after incorporating silver nanoparticles, in vitro study. Bulletin of the National Research Centre 10.1186/s42269-019-0221-8 http://dx.doi.org/10.1186/s42269-019-0221-8.
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  26. Seif M.M., Abdel-Naser Madboli, D.A. Marrez and W.M.K. Aboulthana, 2019. Hepato-renal protective effects of egyptian purslane extract against experimental cadmium toxicity in rats with special emphasis on the functional and histopathological changes. Toxicology Reports 6: 625-631.
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  27. Aboulthana, W.M., A.M. Youssef, A.M. El-Feky, N.E. Ibrahim, M.M. Seif and A.K. Hassan, 2019. Evaluation of antioxidant efficiency of Croton tiglium L. seeds extracts after incorporating silver nanoparticles. Egypt. J. Chem., 62: 181-200.
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  28. Rizk, N.M.H., M.E. Goher, A.S. Eldourghamy, W.M. Aboulthana and Y. Hagag, 2018. Assessment of toxicity induced by different domestic and industrial wastes in nile tilapia (Oreochromis niloticus). Int. J. Bioassays, 7: 5645-5651.
  29. El-Sayed, A.E.K.B., W.M. Aboulthana, A.M. El-Feky, N.E. Ibrahim and M.M. Seif, 2018. Bio and phyto-chemical effect of Amphora coffeaeformis extract against hepatic injury induced by paracetamol in rats. Mol. Biol. Rep., 45: 2007-2023.
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  30. Aboulthana, W.M., A.M. El-Feky, N.E. Ibrahim, R.K. Sahu and A.B. El-Sayed, 2018. Evaluation of the pancreatoprotective effect of Nannochloropsis oculata extract against streptozotocin-induced diabetes in rats. J. Applied Pharm. Sci., 8: 46-58.
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  31. Aboulthana, W.M. and N.E. Ibrahim, 2018. A renoprotective role of chitosan against lithium-induced renal toxicity in rats. Bull. Natl. Res. Centre, Vol. 42. 10.1186/s42269-018-0029-y.
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  32. Aboulthana, W.M. and H.H. Sayed, 2018. How to use green technology to enhance antioxidant efficiency of plant extracts: A novel strategy. J. Applied Pharm., 10: 264-267.
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  33. Seif, M.M., O.A. Ahmed-Farid and W.M. Aboulthana, 2017. Evaluation of the protective effect of Acacia senegal extract against di-(2-ethylhexyl phthalate) induced hepato- and neurotoxicity in rats. Annu. Res. Rev. Biol., 19: 1-17.
  34. Sarkar, A., V.D. Tripathi, R.K. Sahu and W.M. Aboulthana, 2017. Evaluation of anti-inflammatory and anti-arthritis activity of isolated fractions from Bauhinia purpurea leaves extracts in rats. Pharm. Biosci. J., 5: 47-58.
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  35. El-Feky, A.M., W.M. Aboulthana, A.B. El-Sayed and N.E. Ibrahim, 2017. Chemical and therapeutic study of Nannochloropsis oculata on spleen of streptozotocin induced diabetes in rats. Der Pharm. Chem., 9: 36-43.
  36. Abulyazid, I., S.A. Abd Elhalim, H.M. Sharada, W.M. Aboulthana and S.T.A. Abd Elhalim, 2017. Hepatoprotective effect of carob pods extract (Ceratonia siliqua L.) against cyclophosphamide induced alterations in rats. Int. J. Curr. Pharm. Rev. Res., 8: 149-162.
  37. Abdel-halim, A.H., A.A.A. Fyiad, W.M. Aboulthana, A.M. Youssef, N.M. Sabry, W.K.B. Khalil and M.M. Ali, 2017. Evaluation of the therapeutic effect of nano-gold bauhinia-variegata leaves extract against breast cancer- induced rats. Int. J. Pharm. Res., 10.31838/ijpr/2021.13.02.336.
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  38. Abd Elhalim, S.A., H.M. Sharada, I. Abulyazid, W.M. Aboulthana and S.T. Abd Elhalim, 2017. Ameliorative effect of carob pods extract (Ceratonia siliqua L.) against cyclophosphamide induced alterations in bone marrow and spleen of rats. J. Applied Pharm. Sci., 7: 168-181.
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  39. Taha, R.H., S.S. El-Badawy and W.M. Aboulthana, 2016. Screening of bed disinfectants through chromatographic, biological and enzymatic evaluations to diseased silkworm larvae, Bombyx mori (L.) (Lepidoptera : Bombycidae) infected with Beauveria bassiana. Bull. Entmol. Soc. Egypt. Econ. Ser., 42: 63-73.
  40. El-Feky, A.M. and W.M. Aboulthana, 2016. Phytochemical and biochemical studies of sage (Salvia officinalis L.). UK J. Pharm. Biosci., 4: 56-62.
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  41. El-Feky, A. and W.M. Aboulthana, 2016. Herbal Folk Medicine in Egypt: Alternative Medicine and Concept of Herbal Therapy in Egypt. LAP Lambert Academic Publishing, Germany, ISBN: 978-3659898174, Pages: 108.
  42. Attia, A.M.M., F.A.A. Ibrahim, N.A. Abd El-Latif, S.W. Aziz and A.M. Elwan et al., 2016. A simple accurate methods for simultaneous determination of total hemoglobin and its derivatives in human and mice blood. Romanian J. Biophys., 26: 163-174.
  43. Aboulthana, W.M., M. Ismael and H.S. Farghaly, 2016. Electrophoretic and molecular dynamic evaluation of mutagenicity induced by toxic factors affecting testicular tissue in rats. Int. J. Curr. Pharm. Rev. Res., 7: 319-333.
  44. Aboulthana, W.M., M. Ismael and H.S. Farghaly, 2016. Assessment of mutagenicity induced by toxic factors affecting ovarian tissue in rats by electrophoresis and molecular dynamic modeling. Int. J. Curr. Pharm. Rev. Res., 7: 347-359.
  45. Abdalla, M.S., I.A. Ibrahim and W.M. Aboulthana, 2016. Molecular Evaluation of Salicin against Gamma-Irradiation in Rats: Evaluation of Salicin against Irradiation Induced Molecular and Electrophoretic Alterations in Rats. LAP Lambert Academic Publishing, Germany, ISBN: 978-3659793981, Pages: 484.
  46. Sharada, H.M., M.A. Abdel-Kader and W.M.K. Aboulthana, 2015. Biochemical Evaluation of Salicin against Gamma-Irradiation in Rats: Evaluation of Salicin Isolated from Salix subserrata against Irradiation Induced Biochemical Alterations in Rats. LAP Lambert Academic Publishing, Germany, ISBN: 978-3659791031, Pages: 240.
  47. Abulyazid, I., M.S. Abdalla, H.M. Sharada, M.A. Abd El Kader and W.M. Kamel, 2015. Protec ve effect of Salicin isolated from Egyptian willow leaves (Salix subserrata) against gamma radiation-induced electrophoretic and molecular changes in epididymal tissue in rats. Int. J. Recent Sci. Fic Res., 66: 4421-4435.
  48. Abdalla, M.S., H.M. Sharada, I. Abulyazid, M.A. Abd El Kader and W.M. Kamel, 2015. Ameliorative effect of salicin against gamma irradiation induced electrophoretic changes in brain tissue in male rats. UK J. Pharm. Biosci., 3: 29-41.
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  49. Abdalla, M.S. and W.M. Aboulthana, 2015. Advanced Concepts of Lipoproteins: Lipids, Lipoproteins, Apolipoproteins and Their Diseases Association. LAP Lambert Academic Publishing, Germany, ISBN: 978-3659818615, Pages: 124.
  50. Abd El Kader, M.A., I. Abulyazid, M.S. Abdalla, H.M. Sharada and W.M. Kamel, 2015. Evaluaon of salicin isolated from Salix subserrata as a radioprotector against gamma irradiation induced ultrastructural and electrophoretic changes in spleen tissue in rats. UK. J. Pharm. Biosci., 3: 46-59.
  51. Hussein, M.A., S.A.M. Kamal, Y.H. Mohamed and W.M. Kamel, 2014. Studying the effect of different water disinfecting agents on liver and kidney ultrastructure in mice. Curr. Sci. Int., 3: 506-513.
  52. Hussein, M.A., S.A.M. Kamal, Y.H. Mohamed and W.M. Kamel, 2014. Comparative bioanalytical study of chlorine and huwa-san during water treatment in mice. Int. J. Environ., 3: 238-244.
  53. Mohamed, Y.H., N.E. Ibrahim and W.M. Kamel, 2013. Concepts and Theories of Chromatography: Applications of Different Chromatographic Techniques in Central Laboratory of Greater Cairo Drinking Water Company. LAP Lambert Academic Publishing, Germany, ISBN: 978-3659433320, Pages: 104.
  54. Kamel, W.M., Y.H. Mohamed and A.M. Tharwat, 2013. Accreditation of Laboratories: Requirements of Different ISO Certificates. LAP Lambert Academic Publishing, Germany, ISBN: 978-3659451829.
  55. Kamel, W.M., 2013. Principles of Total Organic Halogen Analyzer: Technique for TOX Measurement in Greater Cairo Drinking Water Company. LAP Lambert Academic Publishing, Germany, ISBN: 978-3659409677, Pages: 52.
  56. Kamel, W.M. and M.A. Abd-El Kader, 2013. Theory of Tissue Culture and Stem Cell Therapy: Concepts of Stem Sell Therapy. LAP Lambert Academic Publishing, Germany, ISBN: 978-3659418624, Pages: 88.
  57. Ibrahim, I.A., M.A. Abdel-Kader and W.M. Kamel, 2013. Gamma Irradiation and Concept of Radioprotector. LAP Lambert Academic Publishing, Germany, ISBN: 978-3659357589, Pages: 84.
  58. Hussein, M.A., M.M. El Haloty, S.A. Maksoud, W.M. Kamel, Y.H. Mohamed, A.M. Ibrahim and N.E. Ibrahim, 2013. Using Huwa-san as alternative disinfecting agent for water treatment. Int. J. Bioassays, 2: 605-611.
  59. Hussein, M.A., M.M. El Haloty, S.A. Maksoud, A.S. Ramadan and M.A. Rahman et al., 2013. Evaluation of new water sources to be suitable for drinking purposes. Int. J. Pharma Sci., 3: 175-180.
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  60. Hussein, M.A., A.E.H. El-Seheimy, Y.H. Mohamed, W.M. Kamel and N.E. Ibrahim, 2013. Role of seasonal algal growths on disinfection byproducts of in drinking water of Greater Cairo. Int. J. Pharma Sci., 3: 211-215.
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  61. Hussein, M.A., A.E.H. El-Seheimy, M. El Sayed, M.M. El Haloty, W.M. Kamel, Y.H. Mohamed and N.E. Ibrahim, 2013. Effect of different disinfecting agents on heavy metals during water treatment. Am. Chem. Sci. J., 3: 294-306.
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  62. Elsayed, S.A., Y.H. Mohamed and W.M. Kamel, 2013. Inductively Coupled Plasma-Optical Emission Spectrometry: Concepts, Instrumentation and Different Applications. LAP Lambert Academic Publishing, Germany, ISBN: 978-3659439186, Pages: 80.
  63. Elsayed, A.S., W.M. Kamel and I.A. Ibrahim, 2013. Fundamentals of Gas Proportional Counter: Systems of and Particles Measurement. LAP Lambert Academic Publishing, Germany, ISBN: 978-3659390920, Pages: 76.
  64. El-Haloty, M.M., Y.H. Mohamed and W.M. Kamel, 2013. Disinfection Byproducts: Mechanism of Formation and Techniques for Detection in Drinking Water. LAP Lambert Academic Publishing, Germany, ISBN: 978-3659503054, Pages: 88.
  65. El-Haloty, M.M., W.M. Kamel and Y.H. Mohamed, 2013. Principles and Applications of Total Organic Carbon Analyzer: Technique for Measurement of Total Organic Carbon in Central Laboratory of Greater Cairo Drinking Water Company. LAP Lambert Academic Publishing, Germany, ISBN: 978-3659477249, Pages: 92.
  66. Abd-Elkader, M.A. and W.M. Kamel, 2013. Radioprotective Effect of Salix subserrata against Gamma Irradiation. LAP Lambert Academic Publishing, Germany, ISBN: 978-3659310522, Pages: 356.
  67. Taha, R.H. and W.M. Kamel, 2012. Bacterial disease diagnosis in Bombyx mori L. by thiodiglycol analysis using gas chromatography/mass spectrometry. J. Applied Sci. Res., 8: 4668-4671.
  68. Hussein, M.A., W.M. Kamel and Y.H. Mohamed, 2012. Modern Techniques in Water Research and Technology: Design an Innovative Model for Water Treatment. LAP Lambert Academic Publishing, Germany, ISBN: 978-3659301636, Pages: 184.
  69. Hussein, M.A., A. El-Seheimy, M.M. El Haloty, S.A. Maksoud and W.M. Kamel et al., 2012. Development of new method to minimize trihalomethanes after investigation relation of the individual by-products to the total organic halogen. J. Pharm. Res. Rev., 2: 58-66.
  70. Ibrahim, I., M.S. Abdalla, H.M. Sharada, M.A. Abdel-Kader and W.M. Kamel, 2010. Electrophoretic patterns for the gamma irradiated rats (Ratus norvivicus) after treatment with willow extract. Isotope Radiat. Res., 42: 1273-1287.