Dr. Anna-Mart Engelbrecht
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Dr. Anna-Mart Engelbrecht

Professor
Department of Physiological Sciences, Faculty of Science, Stellenbosch University, South Africa

Highest Degree
Ph.D. in Medical Physiology from Stellenbosch University, South Africa

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Area of Interest:

Biomedical Sciences
100%
Cellular Immunology
62%
Clinical Nutrition
90%
Medical Physiology
75%
Biochemistry
55%

Research Publications in Numbers

Books
4
Chapters
0
Articles
84
Abstracts
0

Selected Publications

  1. Van Niekerk, G., M. Mitchell and A.M. Engelbrecht, 2018. Bone resorption: Supporting immunometabolism. Biol. Lett., Vol. 14, No. 2. 10.1098/rsbl.2017.0783.
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  2. Van Niekerk, G., A. du Toit, B. Loos and A.M. Engelbrecht, 2018. Nutrient excess and autophagic deficiency: Explaining metabolic diseases in obesity. Metab.-Clin. Exp., 82: 14-21.
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  3. Thomas, M., T. Davis, B. Loos, B. Sishi, B. Huisamen, H. Strijdom and A.M. Engelbrecht, 2018. Autophagy is essential for the maintenance of amino acids and ATP levels during acute amino acid starvation in MDAMB231 cells. Cell Biochem. Funct., 36: 65-79.
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  4. Davis, T., G. van Niekerk, J. Peres, S. Prince, B. Loos and A.M. Engelbrecht, 2018. Doxorubicin resistance in breast cancer: A novel role for the human protein AHNAK. Biochem. Pharmacol., 148: 174-183.
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  5. Van Niekerk, G., T. Nell and A.M. Engelbrecht, 2017. Domesticating cancer: An evolutionary strategy in the war on cancer. Front. Oncol., Vol. 7. 10.3389/fonc.2017.00304.
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  6. Van Niekerk, G., T. Davis and A.M. Engelbrecht, 2017. Hyperglycaemia in critically ill patients: The immune system's sweet tooth. Crit. Care, Vol. 21. 10.1186/s13054-017-1775-1.
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  7. Van Niekerk, G., L.M. Davids, S.M. Hattingh and A.M. Engelbrecht, 2017. Cancer stem cells: A product of clonal evolution? Int. J. Cancer, 140: 993-999.
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  8. Mitchell, M.I. and A.M. Engelbrecht, 2017. Metabolic hijacking: A survival strategy cancer cells exploit? Crit. Rev. Oncol./Hematol., 109: 1-8.
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  9. Van Niekerk, G., S.M. Hattingh and A.M. Engelbrecht, 2016. Enhanced therapeutic efficacy in cancer patients by short-term fasting: The autophagy connection. Front. Oncol., Vol. 6. 10.3389/fonc.2016.00242.
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  10. Van Niekerk, G., B. Loos, T. Nell and A.M. Engelbrecht, 2016. Cancer tolerance, resistance, pathogenicity and virulence: Deconstructing the disease state. Future Oncol., 12: 1369-1380.
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  11. Van Niekerk, G., B. Loos, T. Nell and A.M. Engelbrecht, 2016. Autophagy-a free meal in sickness-associated anorexia. Autophagy, 12: 727-734.
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  12. Van Niekerk, G., A.W. Isaacs, T. Nell and A.M. Engelbrecht, 2016. Sickness-associated anorexia: Mother nature's idea of immunonutrition? Mediat. Inflamm., Vol. 2016. 10.1155/2016/8071539.
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  13. Niekerk, G., S.M. Hattingh and A.M. Engelbrecht, 2016. Invertebrates: Why no adaptive immune system? Scand. J. Immunol., 83: 160-161.
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  14. Van Niekerk, G., T. Davis and A.M. Engelbrecht, 2015. Was the evolutionary road towards adaptive immunity paved with endothelium? Biol. Direct, Vol. 10. 10.1186/s13062-015-0079-0.
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  15. Van Niekerk, G. and A.M. Engelbrecht, 2015. On the evolutionary origin of the adaptive immune system-the adipocyte hypothesis. Immunol. Lett., 164: 81-87.
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  16. Mitchell, M.I. and A.M. Engelbrecht, 2015. Circadian rhythms and breast cancer: The role of Per2 in doxorubicin-induced cell death. J. Toxicol., Vol. 2015. 10.1155/2015/392360.
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  17. Leisching, G.R., B. Loos, M.H. Botha and A.M. Engelbrecht, 2015. The role of mTOR during cisplatin treatment in an in vitro and ex vivo model of cervical cancer. Toxicology, 335: 72-78.
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  18. Leisching, G., B. Loos, T. Nell and A.M. Engelbrecht, 2015. Sutherlandia frutescens treatment induces apoptosis and modulates the PI3-kinase pathway in colon cancer cells. S. Afr. J. Bot., 100: 20-26.
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  19. Leisching, G., B. Loos, M. Botha and A.M. Engelbrecht, 2015. Bcl-2 confers survival in cisplatin treated cervical cancer cells: Circumventing cisplatin dose-dependent toxicity and resistance. J. Transl. Med., Vol. 13. 10.1186/s12967-015-0689-4.
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  20. Leisching, G., B. Loos, M. Botha and A.M. Engelbrecht, 2015. A nontoxic concentration of cisplatin induces autophagy in cervical cancer: Selective cancer cell death with autophagy inhibition as an adjuvant treatment. Int. J. Gynecol. Cancer, 25: 380-388.
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  21. Helgeland, E., L. Breivik, B.J. Sishi, A.M. Engelbrecht and A.K. Jonassen, 2015. Intermittent insulin treatment mimics ischemic postconditioning via mitoKATP channels, ROS and RISK. Scand. Cardiovasc. J., 49: 270-279.
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  22. Govender, J., B. Loos and A.M. Engelbrecht, 2015. Melatonin: A protective role against doxorubicin-induced cardiotoxicity. Future Oncol., 11: 2003-2006.
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  23. Govender, J., B. Loos, E. Marais and A.M. Engelbrecht, 2014. Mitochondrial catastrophe during doxorubicin-induced cardiotoxicity: A review of the protective role of melatonin. J. Pineal Res., 57: 367-380.
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  24. Davis, T.A., B. Loos and A.M. Engelbrecht, 2014. AHNAK: The giant jack of all trades. Cell. Signall., 26: 2683-2693.
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  25. Sishi, B.J., B. Loos, J. van Rooyen and A.M. Engelbrecht, 2013. Doxorubicin induces protein ubiquitination and inhibits proteasome activity during cardiotoxicity. Toxicology, 309: 23-29.
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  26. Sishi, B.J., B. Loos, J. van Rooyen and A.M. Engelbrecht, 2013. Autophagy upregulation promotes survival and attenuates doxorubicin-induced cardiotoxicity. Biochem. Pharmacol., 85: 124-134.
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  27. Loos, B., A.M. Engelbrecht, R.A. Lockshin, D.J. Klionsky and Z. Zakeri, 2013. The variability of autophagy and cell death susceptibility: Unanswered questions. Autophagy, 9: 1270-1285.
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  28. Thomas, M.P., J. Mills and A.M. Engelbrecht, 2012. Phosphatidylinositol-3-kinase (PI3K) activity decreases in C2C12 myotubes during acute simulated ischemia at a cost to their survival. Life Sci., 91: 44-53.
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  29. Sishi, B.J., D.J. Bester, A. Wergeland, B. Loos, A.K. Jonassen, J. van Rooyen and A.M. Engelbrecht, 2012. Daunorubicin therapy is associated with upregulation of E3 ubiquitin ligases in the heart. Exp. Biol. Med., 237: 219-226.
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  30. Katengua-Thamahane, E., A.M. Engelbrecht, A.J. Esterhuyse and J. van Rooyen, 2012. Inhibition of Akt attenuates RPO-induced cardioprotection. Cardiol. Res. Pract., Vol. 2012. 10.1155/2012/392457.
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  31. Wergeland, A., D.J. Bester, B.J.N. Sishi, A.M. Engelbrecht, A.K. Jonassen and J. van Rooyen, 2011. Dietary red palm oil protects the heart against the cytotoxic effects of anthracycline. Cell Biochem. Funct., 29: 356-364.
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  32. Sishi, B.J. and A.M. Engelbrecht, 2011. Tumor Necrosis Factor Alpha (TNF-α) inactivates the PI3-kinase/PKB pathway and induces atrophy and apoptosis in L6 myotubes. Cytokine, 54: 173-184.
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  33. Sishi, B., B. Loos, B. Ellis, W. Smith, E.F. du Toit and A.M. Engelbrecht, 2011. Diet-induced obesity alters signalling pathways and induces atrophy and apoptosis in skeletal muscle in a prediabetic rat model. Exp. Physiol., 96: 179-193.
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  34. Loos, B., S. Genade, B. Ellis, A. Lochner and A.M. Engelbrecht, 2011. At the core of survival: Autophagy delays the onset of both apoptotic and necrotic cell death in a model of ischemic cell injury. Exp. Cell Res., 317: 1437-1453.
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  35. Loos, B., A. Lochner and A.M. Engelbrecht, 2011. Autophagy in heart disease: A strong hypothesis for an untouched metabolic reserve. Med. Hypotheses, 77: 52-57.
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  36. Engelbrecht, A.M., C. Smith, I. Neethling, M. Thomas, B. Ellis, M. Mattheyse and K.H. Myburgh, 2010. Daily brief restraint stress alters signaling pathways and induces atrophy and apoptosis in rat skeletal muscle. Stress, 13: 132-141.
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  37. Loos, B. and A.M. Engelbrecht, 2009. Cell death: A dynamic response concept. Autophagy, 5: 590-603.
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  38. Engelbrecht, A.M., L. Odendaal, E.F. du Toit, K. Kupai, T. Csont, P. Ferdinandy and J. van Rooyen, 2009. The effect of dietary red palm oil on the functional recovery of the ischaemic/reperfused isolated rat heart: The involvement of the PI3-kinase signaling pathway. Lipids Health Dis., Vol. 8. 10.1186/1476-511X-8-18.
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  39. Du Toit-Kohn, J.L., L. Louw and A.M. Engelbrecht, 2009. Docosahexaenoic acid induces apoptosis in colorectal carcinoma cells by modulating the PI3 kinase and p38 MAPK pathways. J. Nutr. Biochem., 20: 106-114.
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  40. Van Rooyen, J., A.J. Esterhuyse, A.M. Engelbrecht and E.F. du Toit, 2008. Health benefits of a natural carotenoid rich oil: A proposed mechanism of protection against ischaemia/reperfusion injury. Asia Pac. J. Clin. Nutr., 17: 316-319.
    PubMed  |  Direct Link  |  
  41. Loos, B., R. Smith and A.M. Engelbrecht, 2008. Ischaemic preconditioning and TNF-α-mediated preconditioning is associated with a differential cPLA2 translocation pattern in early ischaemia. Prostaglandins Leukotrienes Essent. Fatty Acids, 78: 403-413.
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  42. Engelbrecht, A.M., J.L. du Toit-Kohn, B. Ellis, M. Thomas, T. Nell and R. Smith, 2008. Differential induction of apoptosis and inhibition of the PI3-kinase pathway by saturated, monounsaturated and polyunsaturated fatty acids in a colon cancer cell model. Apoptosis, 13: 1368-1377.
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  43. Kruger, M.J., A.M. Engelbrecht, J. Esterhuyse, E.F. du Toit and J. van Rooyen, 2007. Dietary red palm oil reduces ischaemia-reperfusion injury in rats fed a hypercholesterolaemic diet. Br. J. Nutr., 97: 653-660.
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  44. Engelbrecht, A.M., M. Mattheyse, B. Ellis, B. Loos and M. Thomas et al., 2007. Proanthocyanidin from grape seeds inactivates the PI3-kinase/PKB pathway and induces apoptosis in a colon cancer cell line. Cancer Lett., 258: 144-153.
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  45. Engelbrecht, A.M. and B. Ellis, 2007. Apoptosis is mediated by cytosolic phospholipase A2 during simulated ischaemia/reperfusion-induced injury in neonatal cardiac myocytes. Prostaglandins Leukotrienes Essent. Fatty Acids, 77: 37-43.
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  46. Engelbrecht, A.M., S. Gebhardt and L. Louw, 2006. Ex vivo study of MAPK profiles correlated with parameters of apoptosis during cervical carcinogenesis. Cancer Lett., 235: 93-99.
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  47. Engelbrecht, A.M., J. Esterhuyse, E.F. du Toit, A. Lochner and J. van Rooyen, 2006. p38-MAPK and PKB/Akt, possible role players in red palm oil-induced protection of the isolated perfused rat heart? J. Nutr. Biochem., 17: 265-271.
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  48. Engelbrecht, A.M., P. Engelbrecht, S. Genade, C. Niesler, C. Page, M. Smuts and A. Lochner, 2005. Long-chain polyunsaturated fatty acids protect the heart against ischemia/reperfusion-induced injury via a MAPK dependent pathway. J. Mol. Cell. Cardiol., 39: 940-954.
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  49. Engelbrecht, A.M., C. Niesler, C. Page and A. Lochner, 2004. p38 and JNK have distinct regulatory functions on the development of apoptosis during simulated ischaemia and reperfusion in neonatal cardiomyocytes. Basic Res. Cardiol., 99: 338-350.
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  50. Louw, L., A.M. Engelbrecht and F. Cloete, 1998. Comparison of the fatty acid compositions in intraepithelial and infiltrating lesions of the cervix: Part III, saturated and unsaturated fatty acid profiles. Prostaglandins Leukotrienes Essent. Fatty Acids, 59: 259-264.
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  51. Louw, L., A.M. Engelbrecht and F. Cloete, 1998. Comparison of the fatty acid compositions in intraepithelial and infiltrating lesions of the cervix: Part I, total fatty acid profiles. Prostaglandins Leukotrienes Essent. Fatty Acids, 59: 247-251.
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  52. Engelbrecht, A.M., L. Louw and F. Cloete, 1998. Comparison of the fatty acid compositions in intraepithelial and infiltrating lesions of the cervix: Part II, free fatty acid profiles. Prostaglandins Leukotrienes Essent. Fatty Acids, 59: 253-257.
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  53. Louw, L., A.M. Engelbrecht, F. Cloete, J.P. van der Westhuizen and L. Dumas, 1997. Impairment in the fatty acid composition of keloids. Adv. Exp. Med. Biol., 400: 905-910.
    PubMed  |  
  54. Louw, L., A.M. Engelbrecht, F. Cloete, J.P. van der Westhuizen and G. Joubert, 1997. The importance of linoleic acid in the total fatty acid compositions of benign and malignant neuroglial tumors. Adv. Exp. Med. Biol., 400: 919-924.
    PubMed  |  
  55. Louw, L., A.M. Engelbrecht and F. Cloete, 1997. Linoleic acid levels in cutaneous tumors with different growth patterns as an additional sensitive diagnostic feature. Adv. Exp. Med. Biol., 400: 911-917.
    PubMed  |