Dr. Emmanuel Van Obberghen
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Dr. Emmanuel Van Obberghen

Research Scientist
University Côte d’Azur, France

Highest Degree
Ph.D. in Medical Science from Free University Brussels, Belgium

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Area of Interest:

Biomedical Sciences
100%
Medicine
62%
Biochemistry
90%
Molecular Biology
75%
Pharmaceutical Research
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Wagner, R., L.H. Hakaste, E. Ahlqvist, M. Heni and J. Machann et al., 2017. Non-suppressed glucagon after glucose challenge as a potential predictor for glucose tolerance. Diabetes, 66: 1373-1379.
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  2. Dumortier, O., E. Roger, D.F. Pisani, V. Casamento and N. Gautier et al., 2017. Age-dependent control of energy homeostasis by brown adipose tissue in progeny subjected to maternal diet-induced fetal programming. Diabetes, 66: 627-639.
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  3. Lopez, P., K.D. Wagner, P. Hofman and E. van Obberghen, 2016. RNA activation of the vascular endothelial growth factor gene (VEGF) promoter by double-stranded RNA and hypoxia: Role of noncoding VEGF promoter transcripts. Mol. Cell. Biol., 36: 1480-1493.
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  4. Dumortier, O., G. Fabris and E. van Obberghen, 2016. Shaping and preserving β‐cell identity with microRNAs. Diabetes Obesity Metab., 18: 51-57.
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  5. Raffort, J., C. Hinault, O. Dumortier and E. van Obberghen, 2015. Circulating microRNAs and diabetes: potential applications in medical practice. Diabetologia, 58: 1978-1992.
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  6. Pisani, D.F., O. Dumortier, G.E. Beranger, V. Casamento and R.A. Ghandour et al., 2015. Visfatin expression is not associated with recruitment and activation of human and rodent brown and brite adipocytes. Adipocyte, 5: 186-195.
  7. Favre, G.A., V.L. Esnault and E. van Obberghen, 2015. Modulation of glucose metabolism by the renin-angiotensin-aldosterone system. Am. J. Physiol.-Endocrinol. Metab., 308: E435-E449.
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  8. Orban, J.C., E.M. Maiziere, A. Ghaddab, E. van Obberghen and C. Ichai, 2014. Incidence and characteristics of acute kidney injury in severe diabetic ketoacidosis. PloS one, Vol. 9 10.1371/journal.pone.0110925.
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  9. Favre, G.A., P. Lebrun, P. Lopez, C. Butori, P. Hofman, V.L. Esnault and E. van Obberghen, 2014. Constitutive activation of the renin-angiotensin system reduces visceral fat and improves glucose tolerance in mice. J. Renin-Angiotensin-Aldosterone Syst., 15: 396-409.
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  10. Dumortier, O., C. Hinault, N. Gautier, S. Patouraux, V. Casamento and E. van Obberghen, 2014. Maternal protein restriction leads to pancreatic failure in offspring: Role of misexpressed microRNA-375. Diabetes, 63: 3416-3427.
    CrossRef  |  Direct Link  |  
  11. Bonesso, L., M. Piraud, C. Caruba, E. van Obberghen, R. Mengual and C. Hinault, 2014. Fast urinary screening of oligosaccharidoses by MALDI-TOF/TOF mass spectrometry. Orphanet J. Rare Dis., Vol. 9 10.1186/1750-1172-9-19.
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  12. Hinault, C., O. Dumortier and E. van Obberghen, 2013. MicroARN et diabete: Petites structures-grands effets. Med. Sci., 29: 785-790.
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  13. Dumortier, O., C. Hinault and E. van Obberghen, 2013. MicroRNAs and metabolism crosstalk in energy homeostasis. Cell metabolism, 18: 312-324.
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  14. Mothe-Satney, I., C. Filloux, H. Amghar, C. Pons and V. Bourlier et al., 2012. Adipocytes secrete leukotrienes: Contribution to obesity-associated inflammation and insulin resistance in mice. Diabetes, 61: 2311-2319.
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  15. Dumortier, O. and E. van Obberghen, 2012. MicroRNAs in pancreas development. Diabetes, Obesity Metab., 14: 22-28.
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  16. Hribal, M.L., I. Presta, T. Procopio, M.A. Marini and A. Stancakova et al., 2011. Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B. Diabetologia, 54: 795-802.
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  17. Fiory, F., A. Lombardi, C. Miele, J. Giudicelli, F. Beguinot and E. van Obberghen, 2011. Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E. Diabetologia, 54: 2941-2951.
    CrossRef  |  Direct Link  |  
  18. Arous, C., M. Naimi and E. van Obberghen, 2011. Oleate-mediated activation of phospholipase D and mammalian target of rapamycin (mTOR) regulates proliferation and rapamycin sensitivity of hepatocarcinoma cells. Diabetologia, 54: 954-964.
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  19. Naimi, M., C. Arous and E. van Obberghen, 2010. Energetic cell sensors: A key to metabolic homeostasis. Trends Endocrinol. Metab., 21: 75-82.
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  20. Lebrun, P., E. Cognard, P. Gontard, R. Bellon-Paul and C. Filloux et al., 2010. The suppressor of cytokine signalling 2 (SOCS2) is a key repressor of insulin secretion. Diabetologia, 53: 1935-1946.
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  21. Sajan, M.P., G. Bandyopadhyay, A. Miura, M.L. Standaert and S. Nimal et al., 2009. AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK- and PDK1-dependent activation of atypical PKC. Am. J. Physiol. Endocrinol. Metab., 298: E179-E192.
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  22. Naimi, M. and E. van Obberghen, 2009. Inflammation: Where is the SPARC in adipose-tissue inflammation? Nat. Rev. Endocrinol., 5: 648-649.
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  23. Lebrun, P., E. Cognard, R. Bellon-Paul, P. Gontard and C. Filloux et al., 2009. Constitutive expression of suppressor of cytokine signalling-3 in skeletal muscle leads to reduced mobility and overweight in mice. Diabetologia, 52: 2201-2212. Diabetologia, 52: 2201-2212.
    CrossRef  |  Direct Link  |  
  24. Hasseine, L.K., C. Hinault, P. Lebrun, N. Gautier, R. Paul-Bellon and E. van Obberghen, 2009. miR-139 impacts FoxO1 action by decreasing FoxO1 protein in mouse hepatocytes. Biochem. Biophys. Res. Commun., 390: 1278-1282.
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  25. Cursio, R., C. Miele, N. Filippa, P. Colosetti, P. Auberger, E. van Obberghen and J. Gugenheim, 2009. Tyrosine phosphorylation of insulin receptor substrates during ischemia/reperfusion-induced apoptosis in rat liver. Langenbeck's Arch. Surg., 394: 123-131.
    CrossRef  |  Direct Link  |  
  26. Baroukh, N.N. and E. van Obberghen, 2009. Function of microRNA‐375 and microRNA‐124a in pancreas and brain. FEBS J., 276: 6509-6521.
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  27. Stancakova, A., J. Pihlajamaki, J. Kuusisto, N. Stefan, A. Fritsche et al., 2008. Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance J. Clin. Endocrinol. Metab., 93: 1924-1930.
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  28. Segalen, C., S. Longnus, D. Baetz, L. Counillon and E. van Obberghen, 2008. 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside reduces glucose uptake via the inhibition of Na+/H+ exchanger 1 in isolated rat ventricular cardiomyocytes. Endocrinology, 149: 1490-1498.
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  29. Schneider, S.M., R. Al-Jaouni, C. Caruba, J. Giudicelli and K. Arab et al., 2008. Effects of age, malnutrition and refeeding on the expression and secretion of ghrelin. Clin. Nutr., 27: 724-731.
    CrossRef  |  Direct Link  |  
  30. Naimi, M. and E. van Obberghen, 2008. Nuclear FoxO1 as a bridge beetwen metabolism and mitogenesis. Med. Sci., 24: 635-640.
    Direct Link  |  
  31. Lebrun, P. and E. van Obberghen, 2008. SOCS proteins causing trouble in insulin action. Acta Physiol., 192: 29-36.
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  32. Laakso, M., J. Zilinskaite, T. Hansen, T.W. Boesgaard and M. Vänttinen et al., 2008. Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study. Diabetologia, 51: 502-511.
    CrossRef  |  Direct Link  |  
  33. El Ouaamari, A., N. Baroukh, G.A. Martens, P. Lebrun, D. Pipeleers and E. Van Obberghen, 2008. miR-375 Targets 3′-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic β-cells. Diabetes, 57: 2708-2717.
    CrossRef  |  Direct Link  |  
  34. Demozay, D., J.C. Mas, S. Rocchi and E. van Obberghen, 2008. Faldh reverses the deleterious action of oxidative stress induced by the lipid peroxidation product, Hne, on insulin signaling in 3T3-L1 adipocytes. Diabetes, 57: 1216-1226.
    CrossRef  |  Direct Link  |  
  35. Cursio, R., C. Miele, N. Filippa, E. van Obberghen and J. Gugenheim, 2008. Liver HIF-1 alpha induction precedes apoptosis following normothermic ischemia-reperfusion in rats. Transplantation Proc., 40: 2042-2045.
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  36. Cassese, A., I. Esposito, F. Fiory, A.P. Barbagallo and F. Paturzo et al., 2008. In skeletal muscle advanced glycation end products (AGEs) inhibit insulin action and induce the formation of multimolecular complexes including the receptor for AGEs. J. Bio. Chem., 283: 36088-36099.
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  37. Candito, M., R. Rivet, B. Herbeth, C. Boisson and R.C. Rudigoz et al., 2008. Nutritional and genetic determinants of vitamin B and homocysteine metabolisms in neural tube defects: A multicenter case-control study. Am. J. Med. Genet. Part A, 146A: 1128-1133.
    CrossRef  |  Direct Link  |  
  38. Naimi, M., N. Gautier, C. Chaussade, A.M. Valverde, D. Accili and E. van Obberghen, 2007. Nuclear forkhead box O1 controls and integrates key signaling pathways in hepatocytes. Endocrinology, 148: 2424-2434.
    CrossRef  |  Direct Link  |  
  39. Hasseine, L.K., J. Murdaca, F. Suavet, S. Longnus, S. Giorgetti-Peraldi and E. van Obberghen, 2007. Hrs is a positive regulator of VEGF and insulin signaling. Exp. Cell Res., 313: 1927-1942.
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  40. Baroukh, N., M.A. Ravier, M.K. Loder, E.V. Hill and A. Bounacer et al., 2007. MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic β-cells lines. J. Bio. Chem., 282: 19575-19588.
    CrossRef  |  Direct Link  |  
  41. Treins, C., J. Murdaca, E. van Obberghen and S. Giorgetti-Peraldi, 2006. AMPK activation inhibits the expression of HIF-1α induced by insulin and IGF-1. Biochem. Biophys. Res. Commun., 342: 1197-1202.
    CrossRef  |  Direct Link  |  
  42. Riboulet-Chavey, A., A. Pierron, I. Durand, J. Murdaca, J. Giudicelli and E. van Obberghen, 2006. Methylglyoxal impairs the insulin signaling pathways independently of the formation of intracellular reactive oxygen species. Diabetes, 55: 1289-1299.
    CrossRef  |  Direct Link  |  
  43. Renard, C., and E. van Obberghen, 2006. Role of diabetes in atherosclerotic pathogenesis. What have we learned from animal models? Diabetes Metab., 32: 15-29.
    CrossRef  |  Direct Link  |  
  44. Hinault, C., I. Mothe-Satney, N. Gautier and E. van Obberghen, 2006. Amino acids require glucose to enhance, through phosphoinositide-dependent protein kinase 1, the insulin-activated protein kinase B cascade in insulin-resistant rat adipocytes. Diabetologia, 49: 1017-1026.
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  45. Hinault, C., E. van Obberghen and I. Mothe-Satney, 2006. Role of amino acids in insulin signaling in adipocytes and their potential to decrease insulin resistance of adipose tissue. J. Nutr. Biochem., 17: 374-378.
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  46. Cursio, R., N. Filippa, C. Miele, E. van Obberghen and J. Gugenheim, 2006. Involvement of protein kinase B and mitogen‐activated protein kinases in experimental normothermic liver ischaemia-reperfusion injury. Br. J. Surg.: Incorporating Eur. J. Surg. Swiss Surg., 93: 752-761.
    CrossRef  |  Direct Link  |  
  47. Cursio, R., C. Miele, N. Filippa, E. van Obberghen and J. Gugenheim, 2006. Alterations in protein tyrosine kinase pathways in rat liver following normothermic ischemia-reperfusion. Transplantation Proc., 38: 3362-3365.
    CrossRef  |  Direct Link  |  
  48. Chavey, C., J. Boucher, M.N. Monthouel‐Kartmann, E.H. Sage and I. Castan‐Laurell et al., 2006. Regulation of secreted protein acidic and rich in cysteine during adipose conversion and adipose tissue hyperplasia. Obesity, 14: 1890-1897.
    CrossRef  |  Direct Link  |  
  49. Candito, M., M. Chatel, E. Candito, M. Lapoussiere, R. Mengual, E. van Obberghen and A. Dunac, 2006. Thrombophilic factors in divers with undeserved decompression sickness. Pathologie-biologie, 54: 155-158.
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  50. Candito, M., J.L. Gueant, M. Naimi, A. Bongain and E. van Obberghen, 2006. Antiepileptic drugs: A case report in a pregnancy with a neural tube defect. Pediat. Neurol., 34: 323-324.
    CrossRef  |  Direct Link  |  
  51. Candito, M., E. Candito, M. Chatel, E. van Obberghen and A. Dunac, 2006. Homocysteinemia and thrombophilic factors in unexplained decompression sickness. Revue Neurologique, 162: 840-844.
    CrossRef  |  PubMed  |  Direct Link  |  
  52. Bortolotti, D., I. Mothe-Satney, P. Ferrari, N. Gautier and J. Sonke et al., 2006. Spontaneous hypoglycaemia in the presence of both anti-insulin antibody and anti-insulin receptor antibody. Diabetes Metab., 32: 598-603.
    CrossRef  |  Direct Link  |  
  53. Treins, C., S. Giorgetti-Peraldi, J. Murdaca, M.N. Monthouël-Kartmann and E. van Obberghen, 2005. Regulation of hypoxia-inducible factor (HIF)-1 activity and expression of HIF hydroxylases in response to insulin-like growth factor I. Mol. Endocrinol., 19: 1304-1317.
    CrossRef  |  Direct Link  |  
  54. Longnus, S.L., C. Segalen, J. Giudicelli, M.P. Sajan, R.V. Farese and E. van Obberghen, 2005. Insulin signalling downstream of protein kinase B is potentiated by 5’ AMP-activated protein kinase in rat hearts in vivo. Diabetologia, 48: 2591-2601.
    CrossRef  |  Direct Link  |  
  55. Lebrun, P., M.R. Montminy and E. van Obberghen, 2005. Regulation of the pancreatic duodenal homeobox-1 protein by DNA-dependent protein kinase. J. Biol. Chem., 280: 38203-38210.
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  56. Gueant-Rodriguez, R.M., Y. Juillière, M. Candito, C.E. Adjalla, P. Gibelin, B. Herbeth and J.L. Gueant, 2005. Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population. Thromb Haemost, 94: 510-515.
    CrossRef  |  
  57. Cursio, R., N. Filippa, C. Miele, P. Colosetti, P. Auberger, E. van Obberghen and J. Gugenheim, 2005. Fas ligand expression following normothermic liver ischemia-reperfusion. J. Surg. Res., 125: 30-36.
    CrossRef  |  Direct Link  |  
  58. Candito, M., L. Grand, G. Fontanabona, F. Caravaca and E. van Obberghen, 2005. Troponin Ic and renal insufficiency. Ann. Bio. Clin., 63: 236-238.
    PubMed  |  Direct Link  |  
  59. Bekri, S., G. Armana, D. De Ricaud, M. Osenda, I. Maire, E. van Obberghen and R. Froissart, 2005. Early diagnosis of mucopolysaccharidosis III A with a nonsense mutation and two de novo missense mutations in SGSH gene. J. Inherited Metab. Dis., 28: 601-602.
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  60. Schneider, S.M., P. Veyres, X. Pivot, A.M. Soummer and P. Jambou et al., 2004. Malnutrition is an independent factor associated with nosocomial infections. Br. J. Nutr., 92: 105-111.
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  61. Pirola, L., A.M. Johnston and E. Van Obberghen, 2004. Modulation of insulin action. Diabetologia, 47: 170-184.
    CrossRef  |  Direct Link  |  
  62. Murdaca, J., C. Treins, M.N. Monthouël-Kartmann, R. Pontier-Bres, S. Kumar, E. Van Obberghen and S. Giorgetti-Peraldi, 2004. Grb10 prevents Nedd4-mediated Vascular Endothelial Growth Factor receptor-2 degradation. J. Biol. Chem., 279: 26754-26761.
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  63. Mothe-Satney, I., N. Gautier, C. Hinault, J.C. Lawrence Jr and E. van Obberghen, 2004. In rat hepatocytes glucagon increases mTOR phosphorylation on serine 2448, but antagonizes the phosphorylation of its downstream targets induced by insulin and amino acids. J. Biol. Chem., 279: 42628-42637.
    CrossRef  |  PubMed  |  Direct Link  |  
  64. Hinault, C., I. Mothe-Satney, N. Gautier, J.C. Lawrence Jr and E. van Obberghen, 2004. Amino acids and leucine allow insulin activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice. FASEB J., 18: 1894-1896.
    CrossRef  |  PubMed  |  Direct Link  |  
  65. Gueant, J.L., M. Candito, E. Andres, E. van Obberghen and J.P. Nicolas, 2004. Familial pernicious anaemia with hyperhomocysteinaemia in recurrent early pregnancy loss. Thrombosis Haemostasis, 91: 1147-1149.
    CrossRef  |  Direct Link  |  
  66. Emanuelli, B., M. Glondu, C. Filloux, P. Peraldi and E. van Obberghen, 2004. The potential role of SOCS-3 in the interleukin-1β-induced desensitization of insulin signaling in pancreatic beta-cells. Diabetes, 53: S97-S103.
    CrossRef  |  Direct Link  |  
  67. Demozay, D., S. Rocchi, J.C. Mas, S. Grillo, L. Pirola, C. Chavey and E. Van Obberghen, 2004. Fatty aldehyde dehydrogenase: Potential role in oxidative stress protection and regulation of its gene expression by insulin. J. Biol. Chem., 279: 6261-6270.
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  68. Candito, M., B. Houcher, C. Boisson, J. Abellard and M.J. Demarcq et al., 2004. Neural tube defects and vitamin B12: A report of three cases. Ann. Biol. Clin., 62: 235-238.
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  69. Bekri, S., C. Fossoud, G. Plaza, A. Guenne, G.S. Salomons, C. Jakobs and E. van Obberghen, 2004. The molecular basis of succinic semialdehyde dehydrogenase deficiency in one family. Mol. Genet. Metab., 81: 347-351.
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  70. Urso, B., M.M. Ilondo, P.A. Holst, C.T. Christoffersen and M. Ouwens et al., 2003. IRS-4 mediated mitogenic signalling by insulin and growth hormone in LB cells, a murine T-cell lymphoma devoid of IGF-I receptors. Cell. Signalling, 15: 385-394.
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  71. Rezzonico, R., C. Cayatte, I. Bourget-Ponzio, G. Romey and N. Belhacene et al., 2003. Focal adhesion kinase pp125FAK interacts with the large conductance calcium-activated hSlo potassium channel in human osteoblasts: Potential role in mechanotransduction. J. Bone Miner. Res., 18: 1863-1871.
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  72. Pirola, L., S. Bonnafous, A.M. Johnston, C. Chaussade, F. Portis and E. Van Obberghen, 2003. Phosphoinositide 3-kinase-mediated reduction of IRS-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells. J. Biol. Chem., 278: 15641-15651.
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  73. Pirola, L., A.M. Johnston and E. Van Obberghen, 2003. Modulators of insulin action and their role in insulin resistance. Int. J. Obes., 27: S61-S64.
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  74. Miele, C., A. Riboulet, M.A. Maitan, F. Oriente and C. Romano et al., 2003. Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase Cα-mediated mechanism. J. Biol. Chem., 278: 47376-47387.
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  75. Johnston, A.M., L. Pirola and E. Van Obberghen, 2003. Molecular mechanisms of insulin receptor substrate proteins as central modulators of insulin signaling. FEBS Lett., 546: 32-36.
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  76. Chavey, C., B. Mari, M.N. Monthouel, S. Bonnafous, P. Anglard, E. van Obberghen and S.T.-Deckert, 2003. Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation. J. Biol. Chem., 278: 11888-11896.
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  77. Chaussade, C., L. Pirola, S. Bonnafous, F. Blondeau and S. Brenz-Verca et al., 2003. Expression of myotubularin by an adenoviral vector demonstrates its function as a phosphatidylinositol 3-phosphate [PtdIns(3)P] phosphatase in muscle cell lines: Involvement of PtdIns(3)P in insulin-stimulated glucose transport. Mol. Endocrinol., 17: 2448-2460.
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  78. Candito, M., S. Magnaldo, J. Bayle, J.F. Dor, Y. Gillet, A. Bongain and E. Van Obberghen, 2003. Clinical B12 deficiency in one case of recurrent spontaneous pregnancy loss. Clin. Chem. Lab. Med., 41: 1026-1027.
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  79. Treins, C., S. Giorgetti-Peraldi, J. Murcada, G.L. Semenza and E. Van Obberghen, 2002. Insulin stimulates Hypoxia-inducible factor 1 through a phosphatidylinositol-3 kinase/target of rapamycin-dependent signaling pathway. J. Biol. Chem., 277: 27975-27981.
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  80. Hieronimus, S., S. Bastard, J.Y. Gillet, J. Giudicelli and F. Brucker-Davis et al., 2002. Significance of cord-blood leptin in newborns of diabetic mothers. Diabetes Care, 25: 1886-1887.
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  81. Candito, M., C. Barro, J.l. Gueant, V. Ducros and B. Pegourie et al., 2002. Hyperhomocysteinemia revealing Biermer disease in two patients. J. Phlebology, 2: 51-55.
  82. Benmerabet, S., A. Fredenrich, J.F. Robillon, B. Canivet, M. Candito and E. Van Obberghen, 2002. Clinical relevance of homocysteine monitoring in the diabetic patient. Diabetes Metab., 28: 510-515.
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  83. Almind, K., L. Delahaye, T. Hansen, E. Van Obberghen, O. Pedersen and R. Kahn, 2002. Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85α. Proc. Natl. Acad. Sci. USA, 99: 2124-2128.
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  84. Van Obberghen, E., V. Baron, L. Delahaye, B. Emmanuelli and N. Filippa et al., 2001. Surfing the insulin signaling web. Eur. J. Clin. Invest., 3: 966-977.
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  85. Treins, C., S. Giorgetti-Peraldi, J. Murdaca and E. van Obberghen, 2001. Regulation of vascular endothelial growth factor expression by advanced glycation end products. J. Biol. Chem., 276: 43836-43841.
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  86. Tartare-Deckert, S., M.N. Monthouel, C. Charvet and I. Foucault et al., 2001. Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte. J. Biol. Chem., 276: 20849-20857.
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  87. Tartare-Deckert, S., C. Chavey, M.N. Monthouel, N. Gautier and E. Van Obberghen, 2001. The matricellular protein SPARC/osteonectin as a newly identified factor up-regulated in obesity. J. Biol. Chem., 276: 22231-22237.
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  88. Pirola, L., M.J. Zvelebil, G. Bulgarelli-Leva, E. Van Obberghen, M.D. Waterfield and M.P. Wymann, 2001. Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase α (PI3Kα): Functions of lipid kinase-deficient PI3Kα in signaling. J. Biol. Chem., 276: 21544-21554.
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  89. Peraldi, P., C. Filloux, B. Emmanuelli, D. Hilton and E. Van Obberghen, 2001. Insulin induces SOCS-3 tyrosine phosphorylation through Jak. J. Biol. Chem., 276: 24614-24620.
  90. Oriente, F., P. Formisano, C. Miele, F. Fiory and M.A. Maitan et al., 2001. Insulin receptor substrate-2 phosphorylation is necessary for protein kinase Cζ activation by insulin in L6hIR cells. J. Biol. Chem., 276: 37109-37119.
    CrossRef  |  
  91. Giorgetti-Peraldi, S., J. Murdaca and E. Van Obberghen, 2001. The adapter protein, Grb10, is a positive regulator of Vascular Endothelial Growth Factor signaling. Oncogene, 20: 3959-3968.
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  92. Emanuelli, B., P. Peraldi, C. Filloux, C. Chavey and K. Freidinger et al., 2001. SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-α in the adipose tissue of obese mice. J. Biol. Chem., 276: 47944-47949.
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  93. Candito, M. and E. Van Obberghen, 2001. Folates, vitamin B12, homocystein and neural tube defects. Ann. Biol. Clin., 59: 111-112.
    Direct Link  |  
  94. Starita-Geribaldi, M., S. Thaon-Scarzzello, E. Van Obberghen and C. Poustis-Delpont, 2000. Two-dimensional polyacrylamide gel electrophoresis of the protease SP220K, a renal cell carcinoma marker. Bioseparation, 9: 133-144.
    CrossRef  |  Direct Link  |  
  95. Sawka-Verhelle, D., S. Tartare-Deckert, J.F. Decaux, J. Girard and E. Van Obberghen, 2000. Stat 5B, activated by insulin in a Jak-independent fashion, plays a role in Glucokinase gene transcription. Endocrinology, 141: 1977-1988.
    CrossRef  |  Direct Link  |  
  96. Rocchi, S., I. Gaillard, E. Van Obberghen, E. Chambaz and I. Vilgrain, 2000. Adrenocorticotrophic hormone stimulates phosphotyrosine phosphatase SHP2 in bovine adrenocortical cells: Phosphorylation and activation by cAMP-dependent protein kinase. Biochem. J., 352: 483-490.
    CrossRef  |  Direct Link  |  
  97. Miranda, C., A. Greco, C. Miele, M.A. Pierotti and E. Van Obberghen, 2000. IRS-1 and IRS-2 are recruited by TrkA receptor and oncogenic TRK-T1. J. Cell. Physiol., 186: 35-46.
    CrossRef  |  Direct Link  |  
  98. Miele, C., J.J. Rochford, N. Filippa, S. Giorgetti-Peraldi and E. Van Obberghen, 2000. Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways. J. Biol. Chem., 275: 21695-21702.
    CrossRef  |  Direct Link  |  
  99. Lebrun, P., V. Baron, C.R. Hauck, D.D. Schlaepfer and E. Van Obberghen, 2000. Cell adhesion and focal adhesion kinase regulate insulin receptor substrate-1 expression. J. Biol. Chem., 275: 38371-38377.
    CrossRef  |  Direct Link  |  
  100. Gual, P., S. Giordano, T.A. Williams, S. Rocchi, E. van Obberghen and P.M. Comoglio, 2000. Sustained recruitment of phospholipase C-γ to Gab1 is required for HGF-induced branching tubulogenesis. Oncogene, 19: 1509-1518.
    CrossRef  |  Direct Link  |  
  101. Filippa, N., C.L. Sable, B.A. Hemmings and E. Van Obberghen, 2000. Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation. Mol. Cell. Biol., 20: 5712-5721.
    CrossRef  |  Direct Link  |  
  102. Emanuelli, B., P. Peraldi, C. Filloux, D. Sawka-Verhelle, D. Hilton and E. Van Obberghen, 2000. SOCS-3 is an insulin-induced negative regulator of insulin signaling. J. Biol. Chem., 275: 15985-15991.
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  103. Delahaye, L., S. Rocchi and E. Van Obberghen, 2000. Potential involvement of FRS2 in insulin signaling. Endocrinology, 241: 621-628.
    CrossRef  |  Direct Link  |  
  104. Miele, C., M. Caruso, V. Calléja, R. Auricchio and F. Oriente et al., 1999. Differential role of insulin receptor substrate (IRS-1) and IRS-2 in L6 skeletal muscle cells expressing the Arg1152 → GIn insulin receptor. J. Biol. Chem., 274: 3094-3102.
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  105. Filippa, N., C. Sable, C. Filloux, B. Hemmings and E. Van Obberghen, 1999. Mechanism of protein kinase B activation by Cyclic AMP-dependent protein kinase. Mol Cell. Biol., 19: 4989-5000.
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  106. Candito, M., P. Bedoucha, P. Gibelin, D. Jambou and R. de Franchis et al., 1999. Fasting, postprandial and post-methionine-load homocysteinaemia and methylene-tetrahydrofolate reductase polymorphism in vascular disease. J. Inher. Metab. Dis., 22: 588-592.
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  107. Almind, K., S.K. Frederiksen, D. Bernal, T. Hansen and L. Ambye et al., 1999. Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: Evaluation of their relation with alterations in insulin secretion and insulin sensitivity. Diabetologia, 42: 1244-1249.
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  108. Sable, C.L., N. Filippa, C. Filloux, B.A. Hemmings and E. Van Obberghen, 1998. Involvement of the pleckstrin homology domain in the insulin-stimulated activation of protein kinase B. J. Biol. Chem., 273: 29600-29606.
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  109. Rocchi, S., S. Tartare-Deckert, J. Murdaca, M. Holgado-Madruga, A.J. Wong and E. van Obberghen, 1998. Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules. Mol. Endocrinol., 12: 914-923.
    CrossRef  |  Direct Link  |  
  110. Némoz-Gaillard, E., M. Cordier-bussat, C. Filloux, J.C. Cuber, E. Van Obberghen, J.A. Chayvialle and J. Abello, 1998. Bombesin stimulates cholecystokinin secretion through mitogen-activated protein-kinase-dependent and-independent mechanisms in the enteroendocrine STC-1 cell line.. J. Biochem., 331: 129-135.
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  111. Lebrun, P., I. Satney-Mothe, L. Delahaye, E. Van Obberghen and V. Baron, 1998. Interaction of the tyrosine kinase pp125fak with the insulin receptor substrate, IRS-1. J. Biol. Chem., 273: 32244-32253.
  112. Kasus-Jacobi, A., D. Perdereau, C. Auzan, E. Clauser and E. Van Obberghen et al., 1998. Identification of the rat adapter Grb14 as an inhibitor of insulin actions. J. Biol. Chem., 273: 26026-26035.
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  113. Gual, P., V. Baron, V. Lequoy and E. Van Obberghen, 1998. Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor. Endocrinology, 139: 884-893.
    CrossRef  |  Direct Link  |  
  114. Delahaye, L., I. Satney-Mothe, M.G. Myers, M.F. White and E. Van Obberghen, 1998. Interaction of insulin receptor substrate-1 (IRS-1) with phosphatidylinositol 3-kinase: Effect of substitution of serine for alanine in potential IRS-1 serine phosphorylation sites. Endocrinology, 139: 4911-4919.
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  115. Baron, V., V. Calléja, P. Ferrari, F. Alengrin and E.Van Obberghen, 1998. p125Fak focal adhesion kinase is a substrate for the insulin and insulin-like growth factor-I tyrosine kinase receptors. J. Biol. Chem., 273: 7162-7168.
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  116. Baron, V., F. Alengrin and E. Van Obberghen, 1998. Dynamin associates with Src-homology collagen (Shc) and becomes tyrosine phosphorylated in response to insulin. Endocrinology, 139: 3034-3037.
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  117. Tanti, J.F., S. Grillo, T. Grémeaux, P.J. Coffer, E. van Obberghen and Y. le Marchand-Brustel, 1997. Potential role of protein kinase B in glucose transporter 4 translocation in adipocytes. Endocrinology, 138: 2005-2010.
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  118. Sawka‐Verhelle, D., C. Filloux, S. Tartare‐Deckert, I. Mothe and E. Van Obberghen, 1997. Identification of Stat 5B as a substrate of the insulin receptor. Eur. J. Biochem., 250: 411-417.
    CrossRef  |  Direct Link  |  
  119. Sawka-Verhelle, D., V. Baron, I. Mothe, C. Filloux, M.F. White and E. Van Obberghen, 1997. Tyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptor. J. Biol. Chem., 272: 16414-16420.
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  120. Sable, C.L., N. Filippa, B. Hemmings and E. Van Obberghen, 1997. cAMP stimulates protein kinase B in a Wortmannin‐insensitive manner. FEBS Lett., 409: 253-257.
    CrossRef  |  Direct Link  |  
  121. Ricort, J.M., J.F. Tanti, E. Van Obberghen and Y. Le Marchand-Brustel, 1997. Cross-talk between the platelet-derived growth factor and the insulin signaling pathways in 3T3-L1 adipocytes. J. Biol. Chem., 272: 19814-19818.
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  122. Mothe, I., L. Delahaye, C. Filloux, S. Pons, M.F. White and E. Van Obberghen, 1997. Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins. Mol. Endocrinol., 11: 1911-1923.
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  123. Kasus-Jacobi, A., D. Perdereau, S. Tartare-Deckert, E. Van Obberghen, J. Girard and A.F. Burnol, 1997. Evidence for a direct interaction between insulin receptor substrate-1 and Shc. J. Biol. Chem., 272: 17166-17170.
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  124. Henry, C., J.F. Tanti, T. Grémeaux, C. Morin, E. Van Obberghen, M. Comet and Y. Le Marchand-Brustel, 1997. Characterization of 6-deoxy-6-iodo-D-glucose: A potential new tool to assess glucose transport. Nuc. Med. Biol., 24: 99-104.
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  125. Calleja, V., P. Ruiz Enríquez, C. Filloux, P. Peraldi, V. Baron and E. Van Obberghen, 1997. The effect of cyclic adenosine monophosphate on the mitogen-activated protein kinase pathway depends on both the cell type and the type of tyrosine kinase-receptor. Endocrinology, 138: 1111-1120.
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  126. Tartare-Deckert, S., J. Murdaca, D. Sawka-Verhelle, K.H. Holt, J.E. Pessin and E. Van Obberghen, 1996. Interaction of the molecular weight 85K regulatory subunit of the phosphatidylinositol 3-kinase with the insulin receptor and the insulin-like growth factor-1 (IGF-I) receptor: Comparative study using the yeast two-hybrid system. Endocrinology, 137: 1019-1024.
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  127. Tanti, J.F., T. Grémeaux, S. Grillo, V. Calleja, A. Klippel, L.T. Williams and Y. Le Marchand-Brustel, 1996. Overexpression of a constitutively active form of phosphatidylinositol 3-kinase is sufficient to promote Glut 4 translocation in adipocytes. J. Biol. Chem., 271: 25227-25232.
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  128. Sawka-Verhelle, D., S. Tartare-Deckert, M.F. White and E. Van Obberghen, 1996. Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591786. J. Biol. Chem., 271: 5980-5983.
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  129. Rocchi, S., S. Tartare-Deckert, D. Sawka-Verhelle, A. Gamha and E. Van Obberghen, 1996. Interaction of SH2-containing protein tyrosine phosphatase 2 with the insulin receptor and the insulin-like growth factor-I receptor: Studies of the domains involved using the yeast two-hybrid system. Endocrinology, 137: 4944-4952.
    CrossRef  |  Direct Link  |  
  130. Ricort, J.M., J.F. Tanti, E. van Obberghen and Y. Le Marchand-Brustel, 1996. Different effects of insulin and platelet‐derived growth factor on phosphatidylinositol 3‐kinase at the subcellular level in 3T3‐L1 adipocytes: A possible explanation for their specific effects on glucose transport. Eur. J. Biochem., 239: 17-22.
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  131. Renaud, F., S. Desset, L. Oliver, G. Gimenez-Gallego, E. Van Obberghen, Y. Courtois and M. Laurent, 1996. The neurotrophic activity of fibroblast growth factor 1 (FGF1) depends on endogenous FGF1 expression and is independent of the mitogen-activated protein kinase cascade pathway. J. Biol. Chem., 271: 2801-2811.
    CrossRef  |  Direct Link  |  
  132. Mothe, I. and E. Van Obberghen, 1996. Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action. J. Biol. Chem., 271: 11222-11227.
    CrossRef  |  Direct Link  |  
  133. Jullien, D., S.J. Heydrick, N. Gautier, E. Van Obberghen and Y. Le Marchand-Brustel, 1996. Effect of IGF-I on phosphatidylinositol 3-kinase in soleus muscle of lean and insulin-resistant obese mice. Diabetes, 45: 869-875.
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  134. Gual, P., V. Baron, F. Alengrin, I. Mothe and E. Van Obberghen, 1996. Insulin receptor-induced phosphorylation of cellular and synthetic substrates is regulated by the receptor beta-subunit C-terminus. Endocrinology, 137: 3416-3423.
    CrossRef  |  Direct Link  |  
  135. Cormont, M., M.N. Bortoluzzi, N. Gautier, M. Mari, E. van Obberghen and Y. Le Marchand-Brustel, 1996. Potential role of Rab4 in the regulation of subcellular localization of Glut4 in adipocytes. Mol. Cell. Biol., 16: 6879-6886.
    CrossRef  |  Direct Link  |  
  136. Cormont, M., E. Van Obberghen, M. Zerial and Y. Le Marchand-Brustel, 1996. Insulin induces a change in Rab5 subcellular localization in adipocytes independently of phosphatidylinositol 3-kinase activation. Endocrinology, 137: 3408-3415.
    CrossRef  |  Direct Link  |  
  137. Bortoluzzi, M.N., M. Cormont, N. Gautier, E. Van Obberghen and Y. Le Marchand-Brustel, 1996. GTPase activating protein activity for Rab4 is enriched in the plasma membrane of 3T3-L1 adipocytes. Possible involvement in the regulation of Rab4 subcellular localization. Diabetologia, 39: 899-906.
    CrossRef  |  Direct Link  |  
  138. Baron, V., P. Gual, F. Alengrin and E. van Obberghen, 1996. Role of the insulin receptor C‐terminal acidic domain in the modulation of the receptor kinase by polybasic effectors. Eur. J. Biochem., 241: 186-192.
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  139. Tartare-Deckert, S., D. Sawka-Verhelle, J. Murdaca and E. Van Obberghen, 1995. Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system. J. Biol. Chem., 270: 23456-23460.
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  140. Rocchi, S., S. Tartare-Deckert, I. Mothe and E. Van Obberghen, 1995. Identification by mutation of the tyrosine residues in the insulin receptor substrate-1 affecting association with the tyrosine phosphatase 2C and phosphatidylinositol 3-kinase. Endocrinology, 136: 5291-5297.
    CrossRef  |  Direct Link  |  
  141. Ricort, J.M., J.F. Tanti, E. Van Obberghen and Y. Le Marchand-Brustel, 1995. Alterations in insulin signalling pathway induced by prolonged insulin treatment of 3T3-L1 adipocytes. Diabetologia, 38: 1148-1156.
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  142. Peraldi, P., M. Frödin, J.V. Barnier, V. Calleja, J.C. Scimeca, C. Filloux and Van E. Obberghen, 1995. Regulation of the MAP kinase cascade in PC12 cells: B-Raf activates MEK-1 (MAP kinase or ERK kinase) and is inhibited by cAMP. FEBS Lett., 357: 290-296.
    CrossRef  |  Direct Link  |  
  143. Mothe, I., S. Tartare, A. Kowalski‐Chauvel, P. Kaliman, E. Van Obberghen and R. Ballotti, 1995. Tyrosine Kinase Activity of a Chimeric Insulin‐Like‐Growth‐Factor‐l Receptor Containing the Insulin Receptor C‐Terminal Domain: Comparison with the Tyrosine Kinase Activities of the Insulin and Msulin‐Like‐Growth‐Factor‐1 Receptors Using a Cell‐Free System. Eur. J. Biochem., 228: 84-848.
    CrossRef  |  Direct Link  |  
  144. Le Marchand-Brustel, Y., S.J. Heydrick, D. Jullien, N. Gautier and E. Van Obberghen, 1995. Effect of insulin and IGF-1 on glucose transport and its transporters in soleus muscle of lean and obese mice. Metabolism, 44: 18-23.
  145. Le Marchand-Brustel, Y., N. Gautier, M. Cormont and E. Van Obberghen, 1995. Wortmannin inhibits the action of insulin but not that of okadaic acid in skeletal muscle: Comparison with fat cells. Endocrinology, 136: 3564-3570.
    CrossRef  |  Direct Link  |  
  146. Heydrick, S.J., N. Gautier, C. Olichon-Berthe, E. Van Obberghen and Y. Le Marchand-Brustel, 1995. Early alteration of insulin stimulation of PI 3-kinase in muscle and adipocyte from gold thioglucose obese mice. Amer. J. Physiol. Endocrinol. Metab., 268: E604-E612.
    CrossRef  |  Direct Link  |  
  147. Hauguel-de-Mouzon, S., C. Mrejen, F. Alengrin and E.Van Obberghen, 1995. Glucose-induced stimulation of human insulin-receptor mRNA and tyrosine kinase activity in cultured cells. Biochem. J., 305: 119-124.
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  148. Gual, P., V. Baron, F. Alengrin and E. Van Obberghen, 1995. A conformational change in the beta-subunit of the insulin-like growth factor I receptor identified by antipeptide antibodies. Endocrinology, 136: 5298-5304.
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  149. Giorgetti‐Peraldi, S., F. Peyrade, V. Baron and E. Van Obberghen, 1995. Involvement of Janus kinases in the insulin signaling pathway. Eur. J. Biochem., 234: 656-660.
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  150. Frödin, M., N. Sekine, E. Roche, C. Filloux, M. Prentki, C.B. Wollheim and E. Van Obberghen, 1995. Glucose, other secretagogues, and nerve growth factor stimulate mitogen-activated protein kinase in the insulin-secreting β-cell line, INS-1. J. Biol. Chem., 270: 7882-7889.
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  151. Baron, V., P. Kaliman, F. Alengrin and E. Van Obberghen, 1995. Interaction of the C‐terminal acidic domain of the insulin receptor with histone modulates the receptor kinase activity. Eur. J. Biochem., 229: 27-34.
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  152. Van Obberghen, E., 1994. Signaling through the insulin receptor and the IGF-I receptor. Diabetologia, 37: S125-S134.
  153. Tartare, S., I. Mothe, A. Kowalski-Chauvel, J.P. Breittmayer, R. Ballotti and E. van Obberghen, 1994. Signal transduction by a chimeric insulin-like growth factor-1 (IGF-1) receptor having the carboxyl-terminal domain of the insulin receptor. J. Biol. Chem., 269: 11449-11455.
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  154. Tanti, J.F., T. Grémeaux, E. Van Obberghen and Y. Le Marchand-Brustel, 1994. Serine/threonine phosphorylation of IRS 1 modulates insulin receptor signaling. J. Biol. Chem., 269: 6051-6057.
    Direct Link  |  
  155. Tanti, J.F., T. Grémeaux, E. Van Obberghen and Y. Le Marchand-Brustel, 1994. Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase. Biochem. J., 304: 17-21.
    CrossRef  |  Direct Link  |  
  156. Ricort, J.M., J.F. Tanti, M. Cormont, E. Van Obberghen and Y. Le Marchand-Brustel, 1994. Parallel changes in Glut 4 and Rab4 movements in two insulin‐resistant states. FEBS Lett., 347: 42-44.
    CrossRef  |  Direct Link  |  
  157. Peraldi, P., Z. Zhao, C. Filloux, E.H. Fischer and E. Van Obberghen, 1994. Protein-tyrosine-phosphatase 2C is phosphorylated and inhibited by 44-kDa mitogen-activated protein kinase. Proc. Natl. Acad. Sci., 91: 5002-5006.
    CrossRef  |  Direct Link  |  
  158. Olichon-Berthe, C., S. Hauguel-De Mouzon, P. Peraldi, E. Van Obberghen and Y. Le Marchand-Brustel, 1994. Insulin receptor dephosphorylation by phosphotyrosine phosphatases obtained from obese insulin-resistant mice. Diabetologia, 37: 56-60.
    Direct Link  |  
  159. Giorgetti, S., P.G. Pelicci, G. Pelicci and E. Van Obberghen, 1994. Involvement of Src‐homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin‐like‐growth‐factor‐I‐receptor. Eur. J. Biochem., 223: 195-202.
    CrossRef  |  Direct Link  |  
  160. Frödin, M., P. Peraldi and E. Van Obberghen, 1994. cAMP activates the MAP-kinase cascade in PC 12 cells. J. Biol. Chem., 269: 6207-6214.
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  161. Cormont, M., J.F. Tanti, E. Van Obberghen and Y. Le Marchand-Brustel, 1994. Expression of guanine-nucleotide-binding proteins in lean and obese insulin-resistant mice. Mol. Cell. Endocrinol., 99: 169-176.
    Direct Link  |  
  162. Cormont, M., J.F. Tanti, A. Zahraoui, E. Van Obberghen and Y. Le Marchand-Brustel, 1994. Rab4 is phosphorylated by the insulin-activated extracellular regulated kinase ERK1. Eur. J. Biochem., 219: 1081-1085.
    Direct Link  |  
  163. Vouret-Craviari, V., E. Van Obberghen-Schilling, J.C. Scimeca, E. Van Obberghen and J. Pouysségur, 1993. Differential activation of P44MAPK (ERK1) by a-thrombrin and thrombin receptor peptide agonist. Biochem. J., 289: 209-214.
  164. Tanti, J.F., T. Grémeaux, M. Cormont, E. Van Obberghen and Y. Le Marchand-Brustel, 1993. Okadaic acid stimulates IGF II receptor translocation and inhibits insulin action in adipocytes. Amer. J. Physiol., 264: E868-E873.
    CrossRef  |  Direct Link  |  
  165. Peraldi, P., J.C. Scimeca, C. Filloux and E. Van Obberghen, 1993. Regulation of ERK1 (pp 44/MAP-kinase) by EGF and NGF in PC12 cells: implication of ERK1 inhibitory activities. Endocrinology, 132: 2578-2585.
  166. Peraldi, P. and E. Van Obberghen, 1993. Insulin and TPA regulate an inhibitor of the 44 kD MAP kinase, ERK1, in fibroblasts. Eur. J. Biochem., 218: 815-821.
  167. Olichon-Berthe, C., N. Gautier, E. Van Obberghen and Y. Le Marchand-Brustel, 1993. Expression of the glucose transporter Glut 4 in muscular dystrophic mdx mouse. Biochem. J., 291: 257-261.
    Direct Link  |  
  168. Nguyen, T.T., J.C. Scimeca, C. Filloux, P. Peraldi and E. Van Obberghen, 1993. Co-regulation of the Map-kinase, ERK1, and the 90-kDa ribosomal S6 kinase in PC12 cells: Distinct effects of the neurotrophic factor, NGF, and the mitogenic factor, EGF. J. Biol. Chem., 268: 9803-9810.
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  169. Mothe, I., R. Ballotti, S. Tartare, A. Kowalski-Chauvel and E. Van Obberghen, 1993. Crosstalk amongst tyrosine kinase receptors in PC12 cells: Desensitization of mitogenic EGF receptors by the neurotrophic factors, NGF and bFGF. Mol. Biol. Cell, 4: 737-746.
    Direct Link  |  
  170. Lebrun, C., V. Baron, P. Kaliman, N. Gautier, J. Dolais-Kitabgi, A. Ullrich, S. Taylor, D. Accili and E. Van Obberghen, 1993. Antibodies to the extracellular receptor domain restore the hormone-insensitive kinase and conformation of the Val 382 mutant insulin receptor. J. Biol. Chem., 268: 11272-11277.
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  171. Kaliman, P., V. Baron, F. Alengrin, N. Takata, J.G. Webster, J. Olefsky and E. Van Obberghen, 1993. The insulin receptor C-terminus is involved in regulation of the receptor kinase activity. Biochemistry, 32: 9539-9544.
    CrossRef  |  Direct Link  |  
  172. Jullien, D., J.F. Tanti, S.J. Heydrick, N. Gautier, T. Grémeaux, E. Van Obberghen and Y. Le Marchand-Brustel, 1993. Differential effects of okadaic acid on insulin stimulated glucose and amino acid uptake and phosphatidylinositol -3- kinase activity. J. Biol. Chem., 268: 15246-15251.
    Direct Link  |  
  173. Heydrick, S., D. Jullien, N. Gautier, J.F. Tanti, S. Giorgetti, E. Van Obberghen and Y. Le Marchand-Brustel, 1993. Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin resistant mice. J. Clin. Invest., 91: 1358-1366.
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  174. Hauguel-de Mouzon, S., P. Peraldi, A. Alengrin and E. Van Obberghen, 1993. Alteration of phosphotyrosine phosphatase activity in tissues from diabetic and pregnant rats. Endocrinology, 132: 67-74.
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  175. Giorgetti, S., R. Ballotti, A. Kowalski-Chauvel, S. Tartare and E. Van Obberghen, 1993. The insulin and Insulin-like Growth Factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol-3-kinase in vitro. J. Biol. Chem., 268: 7358-7364.
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  176. Cormont, M., J.F. Tanti, A. Zahraoui, E. Van Obberghen, A. Tavitian and Y. Le Marchand-Brustel, 1993. Insulin and okadaic acid induce RAB4 redistribution in adipocytes. J. Biol. Chem., 268: 19491-19497.
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  177. Van Obberghen, E., V. Baron, J.C. Scimeca and P. Kaliman, 1992. Insulin Receptor: Receptor activation and signal transduction. Adv. Second Messenger Phosphoprotein Res., 28: 195-201.
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  178. Tartare, S., R. Ballotti, R. Lammers, C. Filloux, A. Chauvel, J. Schlessinger, A. Ullrich and E. Van Obberghen, 1992. Activation of insulin-EGF receptor chimerae regulates EGF receptor binding affinity. J. Cell. Biol., 116: 627-633.
    CrossRef  |  Direct Link  |  
  179. Tanti, J.F., N. Gautier, M. Cormont, V. Baron, E. Van Obberghen and Y. Le Marchand-Brustel, 1992. Potential involvement of the carboxy-terminus of the Glut1 transporter in glucose transport. Endocrinology, 131: 2319-2324.
    CrossRef  |  Direct Link  |  
  180. Scimeca, J.C., T.T. Nguyen, C. Filloux and E. Van Obberghen, 1992. Nerve Growth Factor (NGF)-induced phosphorylation cascade in PC12 pheochromocytoma cells: Association of S6 kinase II with the MAP-kinase, ERK1. J. Biol. Chem., 267: 17369-17374.
    Direct Link  |  
  181. Scimeca, J.C., R. Ballotti, C. Filloux and E. Van Obberghen, 1992. Insulin and orthovanadate stimulate multiple phosphotyrosine-containing serine kinases. Mol. Cell. Biochem., 109: 139-147.
    Direct Link  |  
  182. Peraldi, P., S. Hauguel-de Mouzon, A. Alengrin and E. Van Obberghen, 1992. Dephosphorylation of human IGF-I receptors by membrane-associated tyrosine phosphatases. Biochem. J., 285: 71-78.
    Direct Link  |  
  183. Olichon-Berthe, C., E. Van Obberghen and Y. Le Marchand-Brustel, 1992. Effect of cold acclimation on the expresson of glucose transporter Glut 4. Mol. Cell. Endocrinol., 89: 11-18.
    Direct Link  |  
  184. Kaliman, P., V. Baron, N. Gautier and E. Van Obberghen, 1992. Antipeptide to the IGF-I receptor sequence 1232-1246 inhibits the receptor kinase activity. J. Biol. Chem., 267: 10645-10651.
    Direct Link  |  
  185. Giorgetti, S., R. Ballotti, A. Kowalski-Chauvel, M. Cormont and E. Van Obberghen, 1992. Insulin stimulates PI 3-kinase activity in rat adipocytes. Eur. J. Biochem., 207: 599-606.
    CrossRef  |  Direct Link  |  
  186. Cormont, M., T. Grémeaux, J.F. Tanti, E. Van Obberghen and Y. Le Marchand-Brustel, 1992. Polymixin B inhibits insulin-induced glucose transporter and IGF II receptor translocation in isolated adipocytes. Eur. J. Biochem., 207: 185-193.
    CrossRef  |  Direct Link  |  
  187. Baron, V., P. Kaliman, N. Gautier and E. Van Obberghen, 1992. The insulin receptor activation process involves localized conformational changes. J. Biol. Chem., 267: 23290-23294.
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  188. Ballotti, R., V. Baron, N. Gautier, P. Hainaut and J.C. Scimeca et al., 1992. Activation and regulation of the insulin receptor kinase. Diabete Metab., 18: 98-103.
    Direct Link  |  
  189. Ballotti, R., S. Tartare and E. Van Obberghen, 1992. Le récepteur de l'insuline: mécanisme d'activation et transmission du message. Path. Biol., 40: 754-762.
  190. Tartare, S., R. Ballotti, R. Lammers, F. Alengrin, T. Dull, J. Schlessinger, A. Ullrich and E. Van Obberghen, 1991. Tyrosine Transphosphorylation and Serine/Threonine Phosphorylation of Kinase-Deficient Epidermal Growth Factor (EGF) Receptor Mediated by Insulin-EGF Receptor Chimerae. J. Biol. Chem., 266: 9900-9906.
  191. Tartare, S., R. Ballotti and E. Van Obberghen, 1991. Interaction between heterologous receptor tyrosine kinases: Hormone-stimulated insulin receptors activate unoccupied IGF-I receptors. FEBS Lett., 295: 219-222.
    Direct Link  |  
  192. Tanti, JF., T. Grémeaux, E. Van Obberghen and Y. Le Marchand-Brustel Y, 1991. Effects of okadaic acid, an inhibitor of protein phosphatases-1 and -2A on glucose transport and metabolism in skeletal muscle. J. Biol. Chem., 266: 2099-2103.
    Direct Link  |  
  193. Scimeca, JC., R. Ballotti, TT. Nguyen , C. Filloux and E. Van Obberghen, 1991. Tyrosine and threonine phosphorylation of an immunoaffinity-purified 44 kDa-MAP-kinase. Biochemistry, 30: 9313-9319.
    Direct Link  |  
  194. Hainaut, P., S. Giorgetti, A. Kowalski, R. Ballotti and E. Van Obberghen, 1991. Antibodies to phosphotyrosine injected in Xenopus Laevis oocytes modulate maturation induced by insulin/IGF-I. Exp. Cell. Res., 195: 129-136.
    Direct Link  |  
  195. Hainaut, P., S. Giorgetti, A. Kowalski and E. Van Obberghen, 1991. Insulin-like effects of vanadate on glucose uptake and on maturation in xenopus laevis oocytes. Cell Regul., 2: 317-327.
    Direct Link  |  
  196. Hainaut, P., A. Kowalski, Y. Le Marchand-Brustel, S. Giorgetti and E. Van Obberghen, 1991. Effects of insulin, insulin-like growth factor-I (IGF-I) and progesterone on glucose and amino acid uptake in xenopus laevis oocytes. Mol. Cell. Endocrinol., 75: 133-139.
    Direct Link  |  
  197. Hainaut, P., A. Kowalski, S. Giorgetti, V. Baron and E. Van Obberghen, 1991. Insulin and insulin-like growth factor-I (IGF-I) receptors in xenopus laevis oocytes: comparison with insulin receptors from liver and muscle. Biochem J., 273: 673-678.
    Direct Link  |  
  198. Cormont, M., Y. Le Marchand-Brustel, E. Van Obberghen, A. Spiegel and GWG. Sharp, 1991. Identification of G protein alpha subunits in RINm5F cells and their selective interaction with galanin receptor. Diabetes, 40: 1170-1176.
    Direct Link  |  
  199. Cormont, M., J.F. Tanti, T. Grémeaux, E. Van Obberghen and Y. Le Marchand-Brustel, 1991. Subcellular distribution of low molecular weight GTP-binding proteins in adipocytes. Co-localization with the glucose transporter Glut 4. Endocrinology, 129: 3343-3350.
    CrossRef  |  Direct Link  |  
  200. Baron-Van Evercooren, A., C. Olichon-Berthe, A. Kowalski, G. Visciano Van and E. Obberghen, 1991. Expression of IGF-I and insulin receptor genes in the rat central nervous system: A developmental, regional and cellular analysis. J. Neurosci. Res., 28: 244-253.
    CrossRef  |  Direct Link  |  
  201. Baron, V., N. Gautier, P. Kaliman, J. Dolais-Kitabgi and E. van Obberghen, 1991. The carboxyl-terminus domain of the insulin receptor: Its potential role in growth promoting effects. Biochemistry, 30: 9365-9370.
    CrossRef  |  Direct Link  |  
  202. Ballotti, R., S. Tartare, A. Chauvel, J.C. Scimeca, F. Allengrin and E. Van Obberghen, 1991. Phenylarsine oxide stimulates a cytosolic tyrosine kinase activity and glucose transport in mouse fibroblasts. Exp. Cell Res., 197: 300-306.
    Direct Link  |  
  203. Rochet, N., J.L. Sadoul, B. Ferrua, J. Kubar and J.F. Tanti et al., 1990. Autoantibodies to the insulin receptor are infrequent findings in Type 1 (insulin-dependent) diabetes mellitus of recent onset. Diabetologia, 33: 411-416.
    CrossRef  |  Direct Link  |  
  204. Le Marchand-Brustel, Y., N. Rochet, T. Grémeaux, I. Marot and E. Van Obberghen, 1990. Effect of an α-glycosidase inhibitor on experimentally-induced obesity in mice. Diabetologia, 33: 24-30.
    CrossRef  |  Direct Link  |  
  205. Le Marchand-Brustel, Y., C. Olichon-Berthe, T. Grémeaux, J.F. Tanti, N. Rochet and E. Van Obberghen, 1990. Glucose transporter defect in insulin sensitive tissues of lean and obese mice. Effect of the thermogenic agent, BRL 26830A. Endocrinology, 127: 2687-2695.
    Direct Link  |  
  206. Lammers, R., E. Van Obberghen, R. Ballotti, J. Schlessinger and A. Ullrich, 1990. Transphosphorylation as a possible mechanism for insulin and EGF receptor activation. J. Biol. Chem., 265: 16886-16890.
    Direct Link  |  
  207. Baron, V., N. Gautier, A. Komoriya, P. Hainaut and J.C. Scimeca et al. 1990. Insulin binding to its receptor induces a conformational change in the receptor C-terminus. Biochemistry, 29: 4634-4641.
    CrossRef  |  Direct Link  |  
  208. Tanti, J.F., N. Rochet, T. Grémeaux, E. Van Obberghen and Y. Le Marchand-Brustel, 1989. Insulin-stimulated glucose transport in muscle. Evidence for a protein-kinase-C-dependent component which is unaltered in insulin-resistant mice. Biochem. J., 258: 141-146.
    CrossRef  |  Direct Link  |  
  209. Sharp, G.W.G., Y. Le Marchand-Brustel, T. Yada, L.L. Russo, C.R. Bliss, M. Cormont, L. Monge and E. Van Obberghen, 1989. Galanin can inhibit insulin release by a mechanism other than membrane hyperpolarization or inhibition of adenylate cyclase. J. Biol. Chem., 264: 7302-7309.
    Direct Link  |  
  210. Scimeca, J.C., R. Ballotti, F. Alengrin, A.M. Honegger, A. Ullrich, J. Schlessinger and E. Van Obberghen, 1989. Metabolic effects induced by Epidermal Growth Factor (EGF) in cells expressing EGF receptor mutants. J. Biol. Chem., 264: 6831-6835.
    Direct Link  |  
  211. Rochet, N., S. Blanche, J.C. Carel, A. Fischer, F.L. Deist, C. Griscelli, E. Van Obberghen and Y. Le Marchand-Brustel, 1989. Hypoglycaemia induced by antibodies to insulin receptor following a bone marrow transplantation in an immunodeficient child. Diabetologia, 32: 167-172.
    CrossRef  |  Direct Link  |  
  212. Le Marchand-Brustel, Y., R. Ballotti, T. Grémeaux, J.F. Tanti, D. Brandenburg and E. Van Obberghen, 1989. Functional labeling of insulin receptor subunits in live cells. Alpha 2 beta 2 species is the major autophosphorylated form. J. Biol. Chem., 264: 21316-21321.
    Direct Link  |  
  213. Kubar, J. and E. Van Obberghen, 1989. Oligomeric states of insulin receptor: binding and autophosphorylation properties. Biochemistry, 28: 1086-1093.
    CrossRef  |  Direct Link  |  
  214. Baron, V., N. Gautier, N. Rochet, R. Ballotti, B. Rossi, S. Saint-Pierre, E. Van Obberghen and J. Dolais-Kitabgi, 1989. Antibodies to insulin receptor tyrosine kinase stimulate its activity towards exogenous substrates without inducing receptor autophosphorylation. Biochem J., 260: 749-756.
    CrossRef  |  Direct Link  |  
  215. Ballotti, R., Y. Le Marchand-Brustel, S. Gammeltoft and E. Van Obberghen, 1989. Insulin receptor: tyrosine kinase activity and insulin action. Reprod. Nutr. Dev., 29: 653-661.
    Direct Link  |  
  216. Ballotti, R., R. Lammers, J.C. Scimeca, T. Dull, J. Schlessinger, A. Ullrich and E. Van Obberghen, 1989. Intermolecular transphosphorylation between insulin receptors and EGF-insulin receptor chimerae. EMBO J., 8: 3303-3309.
    CrossRef  |  Direct Link  |  
  217. Ballotti, R., J.C. Scimeca, A. Kowalski and E. Van Obberghen, 1989. Antiphosphotyrosine antibodies modulate insulin receptor kinase activity and insulin action. Cell. Signal., 1: 195-204.
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  218. Van Obberghen, E., J. Kamholz, J.G. Bishop, C. Zomzely-Neurath and R.A. Lazzarini, 1988. Human γ enolase: Isolation of a cDNA clone and expression in normal and tumor tissues of human origin. J. Neurosci. Res., 19: 450-456.
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  219. Rochet, N., J.F. Tanti, T. Gremeaux, E. Van Obberghen and Le Marchand-Brustel, 1988. Effect of a thermogenic agent, BRL 26830A, on insulin receptors in obese mice. Amer. J. Physiol., 255: E101-E109.
    CrossRef  |  Direct Link  |  
  220. Honegger, A., T.J. Dull, F. Bellot, E. Van Obberghen, D. Szapary, Z. Schmidt, A. Ullrich and Schlessinger, 1988. Biological activities of EGF-receptor mutants with individually altered autophosphorylation sites. EMBO, J., 7: 3045-3052.
    CrossRef  |  Direct Link  |  
  221. Gammeltoft, S., R. Ballotti, F.C. Nielsen, A. Kowalski and E. Van Obberghen, 1988. Receptors for Insulin-like Growth Factors in the Central Nervous System: Structure and Function. Hormone, Metab. Res., 20: 436-442.
    CrossRef  |  Direct Link  |  
  222. Gammeltoft, S., R. Ballotti, A. Kowalski, B. Westermark and E. Van Obberghen, 1988. Expression of two types of receptor for insulin-like growth factors in human malignant glioma. Cancer Res., 48: 1233-1237.
    Direct Link  |  
  223. Tanti, J.F., T. Grémeaux, N. Rochet, E. Van Obberghen and Y. Le Marchand-Brustel, 1987. Effect of cyclic AMP-dependent protein kinase on insulin receptor tyrosine kinase activity. Biochem. J., 245: 19-26.
    CrossRef  |  Direct Link  |  
  224. Le Marchand-Brustel, Y., J.F. Tanti, A. Debant, T. Gremeaux and R. Ballotti et al., 1987. Altérations physiopathologiques de la tyrosine kinase du récepteur de l'insuline. Ann. Endocr., 48: 45-46.
  225. Honegger, A.M., T.J. Dull, S. Felder, E. Van Obberghen and F. Bellot et al., 1987. Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing. Cell, 51: 199-209.
    CrossRef  |  Direct Link  |  
  226. Honegger, A.M., D. Szapary, A. Schmidt, R. Lyall, E. Van Obberghen, T.J. Dull, A. Ullrich and J. Schlessinger, 1987. A mutant EGF-receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis. Mol. Cell. Biol., 7: 4568-4571.
    Direct Link  |  
  227. Gremeaux, T., J.F. Tanti, E. Van Obberghen and Y. Le Marchand-Brustel, 1987. Polymyxin B selectively inhibits insulin effects on transport in isolated muscle. Am. J. Physiol., 252: E248-E254.
    Direct Link  |  
  228. Gremeaux, T., J.F. Tanti, E. Van Obberghen and Y. Le Marchand-Brustel, 1987. Alteration of insulin receptor kinase in obese, insulin-resistant mice. Biochimie, 69: 387-393.
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  229. Debant, A., M. Guerre-Millo, Y. Le Marchand-Brustel, P. Freychet, M. Lavau and E. Van Obberghen, 1987. The adipocyte insulin receptor kinase from young obese Zucker rats is hyperresponsive to insulin. Amer. J. Physiol., 252: E273-E277.
  230. Ballotti, R., F.C. Nielsen, N. Pringle, A. Kowalski, W.D. Richardson, E. Van Obberghen and S. Gammeltoft, 1987. Insulin-like Growth Factor-I in cultured rat astrocytes. Expression of the gene and receptor tyrosine kinase. EMBO J., 6: 3633-3639.
    CrossRef  |  Direct Link  |  
  231. Ballotti, R., A. Kowalski, M.F. White, Y. Le Marchand-Brustel and E. Van Obberghen, 1987. Insulin stimulates tyrosine phosphorylation of its receptor β-subunit in intact rat hepatocytes. Biochem. J., 241: 99-104.
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  232. Van Obberghen, E. and S. Gammeltoft, 1986. Insulin receptors: Structure and Function. Experientia, 42: 727-734.
  233. Tanti, J.F., T. Grémeaux, D. Brandenburg, E. Van Obberghen and Y. Le Marchand-Brustel, 1986. Brown adipose tissue in lean and obese mice: Insulin-receptor binding and tyrosine kinase activity. Diabetes, 35: 1243-1248.
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  234. Gammeltoft, S. and E. Van Obberghen, 1986. Protein kinase activity of the insulin receptor. Biochem. J., 235: 1-11.
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  235. Carpentier, J.L., H. Gazzano, E. Van Obberghen, M. Fehlmann, P. Freychet and L. Orci, 1986. Intracellular pathway followed by the insulin receptor covalently coupled to 125I-photoreactive insulin during internalization and recycling. J. Cell Biol., 102: 989-996.
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  236. Carpentier, J.L., A. Robert, G. Grunberger, E. Van Obberghen, P. Freychet, L. Orci and P. Gorden, 1986. Receptor-mediated endocytosis of polypeptide hormones is a regulated process: inhibition of [125I]iodoinsulin internalization in hypoinsulinemic diabetes of rat and man. J. Clin. Endocr. Metab., 63: 151-155.
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  237. Ballotti, R., A. Kowalski, Y. Le Marchand-Brustel and E. Van Obberghen, 1986. Presence of an insulin-stimulated serine kinase in cell extracts from IM-9 cells. Biochem. Biophys. Res. Commun., 139: 179-185.
    PubMed  |  Direct Link  |  
  238. Van Obberghen, E., R. Ballotti, Y. Le Marchand-Brustel, M. Fehlmann, B. Rossi, S. Gammeltoft and A. Kowalski, 1985. Insulin receptor: An Integrated System for Transmembrane Hormone Signaling. In: Regulatory Peptides in Digestive, Nervous and Endocrine Systems, Lewin, M.J.M. and S. Bonfils (Eds.). Vol. 25, Elsevier, Amsterdam pp: 185-193.
  239. Van Obberghen, E., R. Ballotti, H. Gazzano, M. Fehlmann and B. Rossi et al., 1985. The insulin receptor kinase. Biochimie, 67: 1119-1124.
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  240. Sadoul, J.L., J.F. Peyron, R. Ballotti, A. Debant, M. Fehlmann and E. Van Obberghen, 1985. Identification of a cellular 110,000 Da protein substrate for the insulin receptor kinase. Biochem. J., 227: 887-892.
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  241. Robert, A., J.L. Carpentier, E. Van Obberghen, B. Canivet, P. Gorden and L. Orci, 1985. The endosomal compartment of rat hepatocytes: Its characterization in the course of 125I-insulin internalization. Exp. Cell Res., 159: 113-126.
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  242. Peyron, J.F., M. Samson, E. Van Obberghen, D. Brandenburg and M. Fehlmann, 1985. Appearance of a functional insulin receptor during rabbit embryogenesis. Diabetologia, 28: 369-372.
    CrossRef  |  Direct Link  |  
  243. Le Marchand-Brustel, Y., T. Grémeaux, R. Ballotti and E. Van Obberghen, 1985. Insulin receptor tyrosine kinase is defective in skeletal muscle of insulin-resistant obese mice. Nature, 315: 676-679.
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  244. Gazzano, H., P. Halban, M. Prentki, R. Ballotti, D. Brandenburg, M. Fehlmann and E. Van Obberghen, 1985. Identification of functional insulin receptors on membranes from an insulin producing cell line (RINm5F). Biochem. J., 226: 867-872.
    CrossRef  |  Direct Link  |  
  245. Gammeltoft, S., M. Fehlmann and E. Van Obberghen, 1985. Structure and Function of Insulin Receptors in Rat and Human Brain In: Regulatory Peptides in Digestive, Nervous and Endocrine Systems, Lewin, M.J.M. and S. Bonfils (Eds.). Vol. 25, Elsevier, Amsterdam, pp: 195-199.
  246. Gammeltoft, S., M. Fehlmann and E. Van Obberghen, 1985. Insulin receptors in the mammalian central nervous system: Binding characteristics and subunit structure. Biochimie, 67: 1147-1153.
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  247. Gammeltoft, S., G.K. Haselbacher, R.E. Humbel, M. Fehlmann and E. Van Obberghen, 1985. Two types of receptor for insulin‐like growth factors in mammalian brain. EMBO J., 4: 3407-3412.
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  248. Fehlmann, M., Y. Chvatchko, D. Brandenburg, E. Van Obberghen and N. Brossette, 1985. The subunit structure of the insulin receptor and molecular interactions with major histocompatibility complex antigens. Biochimie, 67: 1155-1159.
    CrossRef  |  Direct Link  |  
  249. Fehlmann, M., J.F. Peyron, M. Samson, E. Van Obberghen, D. Brandenburg and N. Brossette, 1985. Molecular association between MHC class I antigens and insulin receptors in mouse liver membranes. Proc. Natl. Acad. Sci., 82: 8634-8637.
    Direct Link  |  
  250. Carpentier, J.L., M. Fehlmann, E. Van Obberghen, P. Gorden and L. Orci, 1985. Insulin receptor internalization and recycling: Mechanism and significance. Biochimie, 67: 1143-1145.
    CrossRef  |  Direct Link  |  
  251. Carpentier, J.L., M. Fehlmann, E. Van Obberghen, P. Gorden and L. Orci, 1985. A possible explanation for non-linear dissociation of 125I-insulin from cell surface receptors on isolated rat hepatocytes. Diabetes, 34: 1002-1007.
  252. Van Obberghen, E., H. Gazzano, A. Kowalski, M. Fehlmann, B. Rossi and G. Ponzio, 1984. The insulin receptor-kinase complex: An integrated system for transmembrane hormone signalling. Biochem. Soc. Trans., 12: 762-766.
  253. Van Obberghen, E., 1984. The insulin receptor: Its structure and function. Biochem. Pharmacol., 33: 889-896.
  254. Van Obberghen, E., 1984. Polypeptide hormones: Pathology and clinical aspects. Acta Histochem. Suppl., 29: 51-55.
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  255. Gammeltoft, S., A. Kowalski, M. Fehlmann and E. Van Obberghen, 1984. Insulin receptors in rat brain: Insulin stimulates phosphorylation of its receptor β-subunit. FEBS Lett., 172: 87-90.
    CrossRef  |  Direct Link  |  
  256. Chvatchko, Y., H. Gazzano, E. Van Obberghen and M. Fehlmann, 1984. Subunit arrangement of insulin receptors in hepatoma cells. Mol. Cell. Endocrinol., 36: 59-65.
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  257. Chvatchko, Y., E. Van Obberghen and M. Fehlmann, 1984. Internalization and recycling of insulin receptors in hepatoma cells. Absence of regulation by receptor occupancy. Biochem. J., 222: 111-117.
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  258. Brossette, N., E. Van Obberghen and M. Fehlmann, 1984. Interaction between insulin receptors and major histocompatibility complex antigens in mouse liver membranes. Diabetologia, 27: 74-76.
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  259. Van Obberghen, E., M. Kasuga and J.A. Hedo, 1983. Structure of the insulin receptor: Studies by external and internal labeling techniques. Reprod. Nutr. Dev., 23: 357-366.
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  260. Van Obberghen, E., B. Rossi, A. Kowalski, H. Gazzano and G. Ponzio, 1983. Receptor-mediated phosphorylation of the hepatic insulin receptor: Evidence that the 95 K receptor subunit is its own kinase. Proc. Natl. Acad. Sci., 80: 945-949.
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  261. Kowalski, A., H. Gazzano, M. Fehlmann and E. Van Obberghen, 1983. Dephosphorylation of the hepatic insulin receptor: Absence of phosphatase activity in purified receptors. Biochem. Biophys. Res. Commun., 117: 885-893.
    CrossRef  |  Direct Link  |  
  262. Kasuga, M., J.L. Carpentier, E. Van Obberghen, L. Orci and P. Gorden, 1983. 125I-anti-insulin receptor Fab is internalized by cultured human lymphocytes. Biochem. Biophys. Res. Commun., 114: 230-233.
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  263. Gazzano, H., A. Kowalski, M. Fehlmann and E. Van Obberghen, 1983. Two different protein kinase activities are associated with the insulin receptor. Biochem. J. 216: 575-582.
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  264. Fehlmann, M., J.L. Carpentier, E. Van Obberghen, D. Brandenburg, L. Orci and P. Freychet, 1983. Internalization and Recycling of Insulin Receptors in Rat Hepatocytes In: Hormones and Cell regulation, Dumont, J.E., J. Nunez and R. Denton (Eds.). Vol. 7, Elsevier Biochemical Press, USA, pp: 59-71.
  265. Fan, J.Y., J.L. Carpentier, P. Gorden, E. Van Obberghen, N.M. Blackett, C. Grunfeld and L. Orci, 1983. The interaction of 125I-insulin with cultured 3T3-L1 adipocytes: Quantitative analysis by the hypothecal grain method. J. Histochem. Cytochem., 31: 859-870.
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  266. Fan, J.Y., J.L. Carpentier, E. Van Obberghen, C. Grunfeld, P. Gorden and L. Orci, 1983. Surface interactions and intracellular localization of cationic ferritin: Similarity to 125I-insulin in 3T3-L1 adipocytes. Eur. J. Cell. Biol., 31: 125-131.
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  267. Fan, J.Y., J.L. Carpentier, E. Van Obberghen, C. Grunfeld, P. Gorden and L. Orci, 1983. Morphological changes of the 3T3-L1 fibroblast plasma membrane upon differentiation to the adipocyte form. J. Cell Sci., 61: 219-230.
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  268. Chvatchko, Y., E. Van Obberghen, N. Kiger and M. Fehlmann, 1983. Immunoprecipitation of insulin receptors by antibodies against class I antigens of the murine-2 major histocompatibility complex. FEBS Lett., 163: 207-211.
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  269. Carpentier, J.L., H. Gazzano, E. Van Obberghen, M. Fehlmann, P. Freychet and L. Orci, 1983. Internalization and recycling of 125I-photoreactive insulin-receptor complexes in hepatocytes in primary culture. Mol. Cell. Endocrinol., 47: 243-255.
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  270. Van Obberghen, E., M. Kasuga, J.A. Hedo and K.M. Yamada, 1982. Structural Features of the Insulin Receptor: Studies by External and Internal Labeling Techniques. In: Hormones and Cell Regulation, Dumont, J.E., J. Nunez and G. Schultz (Eds.). Vol. 6, Elsevier Biomedical Press, USA, pp: 277-293.
  271. Van Obberghen, E., C. Grunfeld, L.C. Harrison, A. Karlsson, M. Muggeo and C.R. Kahn, 1982. Autoantibodies to the insulin receptor and insulin-resistant diabetes. Hormone Res., 16: 280-288.
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  272. Van Obberghen, E. and A. Kowalski, 1982. Phosphorylation of the hepatic insulin receptor: Stimulating effect of insulin on intact cells and in a cell-free system. FEBS Lett., 143: 179-182.
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  273. Kasuga, M., E. van Obberghen, P. Nissley and M. Rechler, 1982. Structure of the insulin-like growth factor receptor in chicken embryo fibroblasts. Proc. Natl. Acad. Sci., 79: 1864-1868.
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  274. Harrison, L.C., A. Itin, M. Kasuga and E. Van Obberghen, 1982. The insulin receptor on the human lymphocyte: Insulin-induced down-regulation of 126,000 and 90,000 glycosylated subunits. Diabetologia, 22: 233-238.
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