Dr. Vincent  Castagne
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Dr. Vincent Castagne

Research Scientist
PORSOLT, France


Highest Degree
Ph.D. in Pharmacology from Institut de Neurosciences Cognitives et Intégratives d Aquitaine, France

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Area of Interest:

Pharmacology and Toxicology
100%
Drug Delivery
62%
Pharmaceutical Sciences
90%
Drug Design
75%
Medicine
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Goineau, S. and V. Castagne, 2018. Electrophysiological characteristics and pharmacological sensitivity of two lines of human induced pluripotent stem cell derived cardiomyocytes coming from two different suppliers. J. Pharmacol. Toxicol. Meth., 90: 58-66.
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  2. Goineau, S. and V. Castagne, 2017. Proarrhythmic risk assessment using conventional and new in vitro assays. Regul. Toxicol. Pharmacol., 88: 1-11.
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  3. Goineau, S. and V. Castagne, 2017. Complementarity of in vitro and in vivo models for the evaluation of gastro-protective effects of pharmacological substances. Fundam. Clin. Pharmacol., 321: 155-164.
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  4. Esneault, E., G. Peyon and V. Castagne, 2017. Efficacy of anticonvulsant substances in the 6 Hz seizure test: Comparison of two rodent species. Epilepsy Res., 134: 9-15.
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  5. Hernier, A.M., C. Froger-Colleaux and V. Castagne, 2016. CNS safety pharmacology: A focus on cognitive functions. J. Pharmacol. Toxicol. Meth., 81: 286-294.
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  6. Goineau, S. and V. Castagne, 2016. Comparison of three preclinical models for nausea and vomiting assessment. J. Pharmacol. Toxicol. Meth., 82: 45-53.
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  7. Froger-Colleaux, C. and V. Castagne, 2016. Effects of baclofen and raclopride on reinstatement of cocaine self-administration in the rat. Eur. J. Pharmacol., 777: 147-155.
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  8. Goineau, S., P. Guillaume and V. Castagne, 2015. Comparison of the effects of clonidine, loperamide and metoclopramide in two models of gastric emptying in the rat. Fundam. Clin. Pharmacol., 29: 86-94.
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  9. Esneault, E., G. Peyon, C. Froger-Colleaux and V. Castagne, 2015. Evaluation of pro-convulsant risk in the rat: Spontaneous and provoked convulsions. J. Pharmacol. Toxicol. Meth., 72: 59-66.
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  10. Le Cudennec, C. and V. Castagne, 2014. Face-to-face comparison of the predictive validity of two models of neuropathic pain in the rat: Analgesic activity of pregabalin, tramadol and duloxetine. Eur. J. Pharmacol., 735: 17-25.
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  11. Goineau, S., P. Guillaume, L. Barrais and V. Castagne, 2014. Automated analysis of delayed emesis in the telemetered ferret: detection of synergistic effects of aprepitant and ondansetron. Fundam. Clin. Pharmacol., 28: 643-651.
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  12. Porsolt, R.D., V. Castagne, E. Hayes and D. Virley, 2013. Nonhuman primates: Translational models for predicting antipsychotic-induced movement disorders. J. Pharmacol. Exp. Ther., 347: 542-546.
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  13. Goineau, S., S. Rompion, P. Guillaume, L. Barrais and V. Castagne, 2013. Using telemetry to automate the detection of emesis in the ferret: New vistas for delayed emesis assessment. J. Pharmacol. Toxicol. Meth., 68: 160-165.
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  14. Goineau, S., J.L. Lacaud, C. Legrand, E. Eveilleaux and V. Castagne, 2013. In vitro safety cardiovascular pharmacology studies: Impact of formulation preparation and analysis. Regul. Toxicol. Pharmacol., 67: 499-505.
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  15. Castagne, V., C. Froger-Colleaux, E. Esneault, A.M. Hernier, M. Lemaire and R.D. Porsolt, 2013. Central Nervous System (CNS) Safety Pharmacology Studies. In: Drug Discovery and Evaluation. Safety and Pharmacokinetic Assays, Vogel, H.G., F.J. Hock, J. Maas and D. Mayer (Eds.)., Springer, Heildelberg, pp: 15-60.
  16. Goineau, S., V. Castagne, P. Guillaume and G. Froget, 2012. The comparative sensitivity of three in vitro safety pharmacology models for the detection of lidocaine-induced cardiac effects. J. Pharmacol. Toxicol. Meth., 66: 52-58.
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  17. Castagne, V., T. Wolinsky, L. Quinn and D. Virley, 2012. Differential behavioral profiling of stimulant substances in the rat using the LABORASTM system. Pharmacol. Biochem. Behav., 101: 553-563.
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  18. Moser, P., T. Wolinsky, V. Castagne and M. Duxon, 2011. Current approaches and issues in non-clinical evaluation of abuse and dependence. J. Pharmacol. Toxicol. Meth., 63: 160-167.
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  19. Lynch, III, J.J., V. Castagne, P.C. Moser and S.W. Mittelstadt, 2011. Comparison of methods for the assessment of locomotor activity in rodent safety pharmacology studies. J. Pharmacol. Toxicol. Meth., 64: 74-80.
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  20. Froger-Colleaux, C., S. Rompion, P. Guillaume, R.D. Porsolt, V. Castagne and P. Moser, 2011. Continuous evaluation of drug withdrawal in the rat using telemetry: Effects of morphine and chlordiazepoxide. J. Pharmacol. Toxicol. Meth., 64: 81-88.
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  21. Porsolt, R.D., P.C. Moser and V. Castagne, 2010. Behavioral indices in antipsychotic drug discovery. J. Pharmacol. Exp. Ther., 333: 632-638.
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  22. Lynch, III, J.J., E.W. Shek, V. Castagne and S.W. Mittelstadt, 2010. The proconvulsant effects of leptin on glutamate receptor-mediated seizures in mice. Brain Res. Bull., 82: 99-103.
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  23. Castagne, V., P. Moser, S. Roux and R.D. Porsolt, 2010. Rodent models of depression: Forced swim and tail suspension behavioral despair tests in rats and mice. Curr. Prot. Pharmacol., 49: 5-8.
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  24. Castagne, V., R.D. Porsolt and P. Moser, 2009. Use of latency to immobility improves detection of antidepressant-like activity in the behavioral despair test in the mouse. Eur. J. Pharmacol., 616: 128-133.
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  25. Castagne, V., P.C. Moser and R.D. Porsolt, 2009. Preclinical behavioral models for predicting antipsychotic activity. Adv. Pharmacol., 57: 381-418.
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  26. Esneault, E., V. Castagne, P. Moser, C. Bonny and M. Bernaudin, 2008. D-JNKi, a peptide inhibitor of c-Jun N-terminal kinase, promotes functional recovery after transient focal cerebral ischemia in rats. Neuroscience, 152: 308-320.
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  27. Castagne, V., P. Moser and R.D. Porsolt, 2008. Behavioral Assessment of Antidepressant Activity in Rodents. In: Methods of Behavioral Analysis in Neuroscience, Buccafusco, J.J. (Ed.)., Taylor and Francis, Boca Raton, Florida.
  28. Castagne, V., M. Lemaire, I. Kheyfets, J.L. Dugina, S.A. Sergeeva and O.I. Epstein, 2008. Antibodies to S100 proteins have anxiolytic‐like activity at ultra‐low doses in the adult rat. J. Pharm. Pharmacol., 60: 309-316.
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  29. Castagne, V., R.D. Porsolt and P. Moser, 2006. Early behavioral screening for antidepressants and anxiolytics. Drug Dev. Res., 67: 729-742.
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  30. Castagne, V., M. Rougemont, M. Cuenod and K.Q. Do, 2004. Low brain glutathione and ascorbic acid associated with dopamine uptake inhibition during rat's development induce long-term cognitive deficit: Relevance to schizophrenia. Neurobiol. Dis., 15: 93-105.
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  31. Castagne, V., M. Cuenod and K.Q. Do, 2004. An animal model with relevance to schizophrenia: Sex-dependent cognitive deficits in osteogenic disorder-Shionogi rats induced by glutathione synthesis and dopamine uptake inhibition during development. Neuroscience, 123: 821-834.
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  32. Rougemont, M., K.Q. Do and V. Castagne, 2002. New model of glutathione deficit during development: Effect on lipid peroxidation in the rat brain. J. Neurosci. Res., 70: 774-783.
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  33. Lefevre, K., P.G. Clarke, E.E. Danthe and V. Castagne, 2002. Involvement of cyclin‐dependent kinases in axotomy‐induced retinal ganglion cell death. J. Comparat. Neurol., 447: 72-81.
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  34. Borsello, T., V. Mottier, V. Castagne and P.G. Clarke, 2002. Ultrastructure of retinal ganglion cell death after axotomy in chick embryos. J. Comparat. Neurol., 453: 361-371.
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  35. Castagne, V., K. Lefevre and P.G.H. Clarke, 2001. Dual role of the NF-κB transcription factor in the death of immature neurons. Neuroscience, 108: 517-526.
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  36. Castagne, V. and P.G. Clarke, 2000. Neuroprotective effects of a new glutathione peroxidase mimetic on neurons of the chick embryo's retina. J. Neurosci. Res., 59: 497-503.
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  37. Castagne, V., P. Barneoud and P.G. Clarke, 1999. Protection of axotomized ganglion cells by salicylic acid. Brain Res., 840: 162-166.
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  38. Castagne, V., M. Gautschi, K. Lefevre, A. Posada and P.G.H. Clarke, 1999. Relationships between neuronal death and the cellular redox status focus on the developing nervous system. Prog. Neurobiol., 59: 397-423.
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  39. Castagne, V., K. Lefevre, R. Natero, D.A. Becker and P.G.H. Clarke, 1999. An optimal redox status for the survival of axotomized ganglion cells in the developing retina. Neuroscience, 93: 313-320.
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  40. Castagne, V. and P.G. Clarke, 1999. Inhibitors of mitogen-activated protein kinases protect axotomized developing neurons. Brain Res., 842: 215-219.
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  41. Clarke, P.G.H., A. Posada, M.P. Primi and V. Castagne, 1998. Neuronal death in the central nervous system during development. Biomed. Pharmacother., 52: 356-362.
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  42. Castagne, V. and P.G.H. Clarke, 1998. Cooperation between glutathione depletion and protein synthesis inhibition against naturally occurring neuronal death. Neuroscience, 86: 895-902.
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  43. Castagne, V. and P.G. Clarke, 1997. Inhibition of glutathione synthesis can enhance cycloheximide-induced protection of developing neurons against axotomy. Dev. Brain Res., 102: 285-290.
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  44. Castagne, V., J.C.E. Maire and M. Gyger, 1996. Neurotoxicology and amino acid intake during development: The case of threonine. Pharmacol. Biochem. Behav., 55: 653-662.
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  45. Castagne, V. and P.G. Clarke, 1996. Axotomy-induced retinal ganglion cell death in development: Its timecourse and its diminution by antioxidants. Proc. R. Soc. Lond. B, 263: 1193-1917.
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  46. Castagne, V., J.C. Maire, D. Moennoz and M. Gyger, 1995. Effect of threonine on the behavioural development of the rat. Pharmacol. Biochem. Behav., 52: 281-289.
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  47. Castagne, V., P.A. Finot and J.C. Maire, 1994. Effects of diet-induced hyperthreoninemia. II) Tissue and extracellular amino acid levels in the brain. Life Sci., 54: 41-48.
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  48. Castagne, V., D. Moennoz, P.A. Finot and J.C. Maire, 1993. Effects of diet-induced hyperthreoninemia. I) amino acid levels in the central nervous system and peripheral tissues. Life Sci., 53: 1803-1810.
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  49. Corder, R., V. Castagne, J.M. Rivet, P. Mormede and R.C. Gaillard, 1992. Central and peripheral effects of repeated stress and high NaCl diet on neuropeptide Y. Physiol. Behav., 52: 205-210.
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  50. Castagne, V., J.M. Rivet and P. Mormede, 1990. The integrity of the ventral noradrenergic bundle (VNAB) is not necessary for a normal neuroendocrine stress response. Brain Res., 511: 349-352.
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  51. Rivet, J.M., V. Castagne, R. Corder, R. Gaillard and P. Mormede, 1989. Study of the influence of stress and adrenalectomy on central and peripheral neuropeptide Y levels. Neuroendocrinology, 50: 413-420.
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  52. Castagne, V., R. Corder, R. Gaillard and P. Mormede, 1987. Stress-induced changes of circulating neuropeptide Y in the rat: Comparison with catecholamines. Regul. Peptides, 19: 55-63.
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