Dr. Jean-Marc Sabatier
My Social Links

Dr. Jean-Marc Sabatier

Research Scientist
Industry Research Laboratory, France

Highest Degree
Ph.D. in Biology from Industry Research Laboratory, France

Share this Profile

Biography

Dr. Jean-Marc Sabatier is currently working as Director of Research at Centre National De La Recherche Scientifique (CNRS), France. He obtained his Ph.D. in Biology from Industry Research Laboratory, France. His area of expertise includes Drug Design and Synthesis (peptides and related compounds), Optimization of Peptide Structure/Conformation (to improve bioactivity, selectivity, solubility, and/or stability), Peptide and Protein Engineering, Development of Peptide Based in Vitro Assays (diagnostic tests, etc.), Toxicology, and Evaluation of Research Projects. He was received Award of the best Scientific Advance, XVIIeme Rencontres Transfrontalieres Capteurs et Biocapteurs, Tarragona (Spain), Award of best communication, 1996, Achievement Award (ABI, Raleigh, US), International Man of the Year Award (IBC, Cambridge, UK), and Neosystem Award for the most distinguished work on structure-activity relationship studies of peptides, 9th Peptides & Proteins Meeting, Aussois (France). He is professional member of The International Neuropeptide Society; The New-York Academy of Sciences; American Society for Microbiology; American Peptide Society (charter member); American Society for Biochemistry and Molecular Biology (on behalf of the editor of J. Biol. Chem.); Biochemical Society (on behalf of the Editor of The Biochemical Journal); Federation of American Societies for Experimental Biology; European Peptide Society; International Society on Toxinology; Societe Francaise des Peptides et des Proteines; Societe Francaise de Biochimie et Biologie Moleculaire; Societe Francaise de Microbiologie; Groupement Detude Des Polypeptides Actifs; Association pour la Promotion de la Recherche en Interactions Cellulaires. He has published 130 articles in journals as well 160 congress reports and 53 patents contributed as author/co-author. He is member of editorial board in more than 28 journals.

Area of Interest:

Chemistry
100%
Biochemistry
62%
Protein Chemistry
90%
Drug Design
75%
Synthesis
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Mousslim, M., A. Pagano, N. Andreotti, F. Garrouste and S. Thuault et al., 2017. Peptide screen identifies a new NADPH oxidase inhibitor: Impact on cell migration and invasion. Eur. J. Pharmacol., 794: 162-172.
    CrossRef  |  Direct Link  |  
  2. Memariani, H., D. Shahbazzadeh, J.M. Sabatier, M. Memariani, A. Karbalaeimahdi and K.P. Bagheri, 2016. Mechanism of action and in vitro activity of short hybrid antimicrobial peptide PV3 against Pseudomonas aeruginosa. Biochem. Biophys. Res. Commun., 479: 103-108.
    CrossRef  |  Direct Link  |  
  3. Ghodhbane, H., V. Alessandria, M. Snoussi, L. Elleuch and I. Trabelsi et al., 2016. Genetic characterization of lactic acid bacteria isolated from tunisian milk waste and their antimicrobial activity against some bacteria implicated in nosocomial infections. Infect. Disord. Drug Targets, 16: 182-191.
    Direct Link  |  
  4. Oukkache, N., R. ElJaoudi, , F. Chgoury, M.T. Rocha and J.M. Sabatier, 2015. Characterization of Am IT, an anti-insect β-toxin isolated from the venom of scorpion Androctonus mauretanicus. Acta Physiol. Sinica, 67: 295-304.
    PubMed  |  
  5. Oukkache, N., M.R.A. Rusmili, I. Othman, N. Ghalim, F. Chgoury, L. Boussadda and J.M. Sabatier, 2015. Comparison of the neurotoxic and myotoxic effects of two moroccan scorpion venoms and their neutralization by experimental polyclonal antivenom. Life sci., 124: 1-7.
    CrossRef  |  Direct Link  |  
  6. Murthy, S.R., T. Sherrin, C. Jansen, I. Nijholt, M. Robles, A.M. Dolga and T. Blank, 2015. Small-conductance ca 2+-activated potassium type 2 channels regulate the formation of contextual fear memory. PLoS One, 10.1371/journal.pone.0127264.
    CrossRef  |  Direct Link  |  
  7. Ghodhbane, H., S. Elaidi, J.M. Sabatier, S. Achour, J. Benhmida and I. Regaya, 2015. Bacteriocins active against multi-resistant gram negative bacteria implicated in nosocomial infections. Infect. Disord. Drug Targets, 15: 2-12.
    Direct Link  |  
  8. Dardevet, L., D. Rani, T.A.E. Aziz, I. Bazin, J.M. Sabatier, M. Fadl and M. De Waard, 2015. Chlorotoxin: A helpful natural scorpion peptide to diagnose glioma and fight tumor invasion. Toxins, 7: 1079-1101.
    CrossRef  |  Direct Link  |  
  9. Aidi-Knani, S., L. Pezard, B. Mpari, J.B. Hamida, J.M. Sabatier, C. Mourre and I. Regaya, 2015. Correspondences between the binding characteristics of a non-natural peptide, Lei-Dab7, and the distribution of SK subunits in the rat central nervous system. Eur. J. Pharmacol., 752: 106-111.
    CrossRef  |  Direct Link  |  
  10. Yang, W., J. Feng, F. Xiang, Z. Xie, G. Zhang, J.M. Sabatier and Y. Wu, 2014. Endogenous animal toxin-like human β-defensin 2 inhibits own K+ channels through interaction with channel extracellular pore region. Cell. Mol. Life Sci., 72 : 845-853.
    CrossRef  |  Direct Link  |  
  11. Oukkache, N., R. El Jaoudi, N. Ghalim, F. Chgoury, B. Bouhaouala, N. El Mdaghri and J.M. Sabatier, 2014. Evaluation of the lethal potency of scorpion and snake venoms and comparison between intraperitoneal and intravenous injection routes. Toxins, 6: 1873-1881.
    CrossRef  |  PubMed  |  
  12. Chen, Z., Y. Hu, J. Hu, W. Yang and J.M. Sabatier et al., 2014. Unusual binding mode of scorpion toxin BmKTX onto potassium channels relies on its distribution of acidic residues. Biochem. Biophys. Res. Comm., 447: 70-76.
    CrossRef  |  PubMed  |  
  13. Accary, C., S. Hraoui-Bloquet, M. Hamze, Y. Mallem and F. El Omar et al., 2014. Protein content analysis and antimicrobial activity of the crude venom of Montivipera Bornmuelleri, a viper from Lebanon. Disord. Drug Targets, 14: 49-55.
    PubMed  |  
  14. Tisseyre, C., E. Bahembera, L. Dardevet, J.M. Sabatier, M. Ronjat and M. De Waard, 2013. Cell penetration properties of a highly efficient mini Maurocalcine peptide. Pharmaceuticals, 6: 320-339.
    CrossRef  |  Direct Link  |  
  15. Regaya, I., S. Aidi-Knani, Y. By, C. Condo and V. Gerolami et al., 2013. SKCa channels blockage increases the expression of Adenosine A2A receptor in Jurkat human T cells. Biores. Open Access, 2: 163-168.
    CrossRef  |  PubMed  |  
  16. Feng, J., Y. Hu, H. Yi, S. Yin and S. Han et al., 2013. Two conserved arginine residues from the SK3 channel outer vestibule control selectivity of recognition by scorpion toxins. J. Biol. Chem., 288: 12544-12553.
    CrossRef  |  PubMed  |  
  17. Bazin, I., N. Andreotti, A.I. Hassine, M. De Waard, J.M. Sabatier and C. Gonzalez, 2013. Peptide binding to Ochratoxin A mycotoxin: A new approach in conception of biosensors. Biosensors Bioelect., 40: 240-246.
    CrossRef  |  PubMed  |  
  18. Andreotti, N. and J.M. Sabatier, 2013. The deciphered genome of Mesobuthus martensii uncovers the resistance mysteries of scorpion to its own venom and toxins at the ion channel level. Toxins, 5: 2209-2211.
    CrossRef  |  Direct Link  |  
  19. Poillot, C., H. Bichraoui, C. Tisseyre, E. Bahemberae and N. Andreotti et al., 2012. Small efficient cell-penetrating peptides derived from scorpion toxin maurocalcine. J. Biol. Chem., 287: 17331-17342.
  20. Lasta, S., H. Ouzari, N. Andreotti, Z. Fajloun and P. Mansuelle et al., 2012. Lacticin LC14, a new bacteriocin produced by Lactococcus lactis BMG6.14: Isolation, purification and partial characterization. Infect. Disord. Drug Targets, 12: 316-325.
    Direct Link  |  
  21. Kasumu, A.W., C. Hougaard, F. Rode, T.A. Jacobsen and J.M. Sabatier et al., 2012. Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar Ataxia type 2. Chem. Biol., 19: 1340-1353.
    CrossRef  |  
  22. Andreotti, N., H. Ziadi, S. Mouhat, M. De Waard and J.M. Sabatier, 2012. Strategies toward structural and functional optimization of animal peptide toxins. Int. J. Med. Biomed. Res., 1: 91-96.
    Direct Link  |  
  23. Fajloun, Z., N. Andreotti, M. Fathallah, J.M. Sabatier and M. De Waard et al., 2011. Analysis of the interacting surface of maurotoxin with the voltage-gated Shaker B K+ channel. Pept. Sci., 17: 200-210.
    CrossRef  |  
  24. Kallech-Ziri, O., J. Luis, Z. Fajloun, J.M. Sabatier and M. Lehmann et al., 2010. Structure-function relationships of KTS disintegrins and design of antiangiogenic drugs. Lett. Drug Design Discovery, 7: 36-40.
  25. Bregeon, F., J.G. Steinberg, N. Andreotti, J.M. Sabatier and S. Delpierre et al., 2010. SP receptor blockade decreases stretch-induced lung cytokines and lung injury. J. Physiol., 588: 1309-1319.
    PubMed  |  
  26. Andreotti, N., B. Jouirou, S. Mouhat, L. Mouhat and J.M. Sabatier, 2010. Therapeutic Value of Peptides from Animal Venoms. In: Amino ACIDS, Peptides and Proteins, Comprehensive Natural Products II Chemistry and Biology, Mander, L. and H.D. Lui (Eds.). Elsevier, Oxford, pp: 287-303.
  27. Nijholt, I., H. Van den Akker, M.J. Kye, J.M. Sabatier and H. Knaus et al., 2009. Small-conductance Ca2+-activated potassium type 2 channels regulate the formation of contextual fear memory. J. Neurosci. in press. .
  28. Regaya, I., N. Andreotti, E. Di Luccio, M. De Waard and J.M. Sabatier et al., 2008. Effect of Cu2+ on the oxidative folding of synthetic Maurotoxin in vitro. J. Biomol. Struct. Dyn., 26: 75-82.
    Direct Link  |  
  29. Ram, N., N. Weiss, I. Texier-Nogues, S. Aroui and N. Andreotti et al., 2008. Design of a disulfide-less, pharmacologically-inert and chemically-competent analog of Maurocalcine for the efficient transport of impermeant compounds into cells. J. Biol. Chem., 283: 27048-27056.
    Direct Link  |  
  30. Pimentel, C., M.S. Barek, V. Visan, S. Grissmer and F. Sampieri et al., 2008. Chemical synthesis and 1H-NMR 3D structure determination of AgTx2-MTX chimera, a new potential blocker for Kv1.2 channel, derived from MTX and AgTx2 scorpion toxins. Protein Sci., 17: 107-118.
    CrossRef  |  PubMed  |  
  31. Mouhat, S., N. Andreotti, B. Jouirou and J.M. Sabatier, 2008. Animal toxins acting on voltage-gated potassium channels. Curr. Pharm. Des., 14: 2503-2518.
    PubMed  |  
  32. Lasta, S., Z. Fajloun, H. Darbon, P. Mansuelle and N. Andreotti et al., 2008. Chemical synthesis and characterization of J46 peptide, an atypical class IIa bacteriocin from Lactococcus lactis subsp. cremoris J46 strain. J. Antibiotics, 61: 89-93.
    PubMed  |  
  33. Wulff, H., A. Kolski-Andreaco, A. Sankaranayanan, J.M. Sabatier and V. Shakkottai et al., 2007. Modulators of small and intermediate conductance calcium-activated potassium channels and their therapeutic indications. Curr. Med. Chem., 14: 1437-1457.
    PubMed  |  
  34. Pouvreau, S., L. Csernoch, B. Allard, J.M. Sabatier and M. De Waard et al., 2006. Transient loss of voltage control of Ca2+ release in the presence of maurocalcine in skeletal muscle. Biophys. J., 91: 2206-2215.
    PubMed  |  
  35. Mouhat, S., G. Teodorescu, D. Homerick, V. Visan and H. Wulff et al., 2006. Pharmacological profiling of OSK1 analogues with a trimmed N-terminal domain.. Mol. Pharmacol., 69: 354-362.
    PubMed  |  
  36. Guieu, R., E. Fenouillet, C. Devaux, Z. Fajloun and L. Carrega et al., 2006. CD26 modulates nociception in mice via its dipeptidyl-peptidase IV activity. Behav. Brain Res., 166: 230-235.
    PubMed  |  
  37. Courcambeck, J., M. Bouzidi, R. Perbost, B. Jouirou and N. Amrani et al., 2006. Resistance of Hepatitis C virus to NS3-4A protease inhibitors: Molecular mechanism of drug resistance induced by R155Q, A156T, D168A and D168V mutations. Antiviral Ther., 11: 847-855.
    PubMed  |  
  38. Boisseau, S., K. Mabrouk, R. Narendra, N. Garmy and V. Collin et al., 2006. Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. Biochem. Biophys. Acta, 1758: 308-319.
    PubMed  |  
  39. Beraud-Juven, E., A. Viola, I. Regaya, C. Gouny and P. Siaud et al., 2006. Block of neural Kv1.1 potassium channels for neuroinflammatory disease therapy. Ann. Neurol., 60: 586-596.
    PubMed  |  
  40. Szappanos, H., S. Smida-Rezgui, J. Cseri, C. Simut and J.M. Sabatier et al., 2005. Differential effects of maurocalcine on Ca2+ release events and depolarisation-induced Ca2+ release in rat skeletal muscle. J. Physiol., 565: 843-853.
  41. Olfa, K.Z., L. Jose, D. Salma, B. Amine and S.A. Najet et al., 2005. Lebestatin, a disintegrin from Macrovipera venom, inhibits integrin-mediated cell adhesion, migration and angiogenesis. Lab. Invest., 85: 1507-1516.
    CrossRef  |  PubMed  |  
  42. Mouhat, S., V. Visan, S. Ananthakrishnan, H. Wulff and S. Grissmer et al., 2005. K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom. Biochem. J., 385: 95-104.
    CrossRef  |  PubMed  |  
  43. Mouhat, S., M. De Waard, J.M. Sabatier and J. Peptide, 2005. Contribution of the functional dyad of animal toxins acting on voltage-gated Kv1-type channels. Sciences, 11: 65-68.
    PubMed  |  
  44. M'Barek, S., B. Chagot, N. Andreotti, V. Visan and P. Mansuelle et al., 2005. Acting on the number of molecular contacts between Maurotoxin and Kv1.2 channel impacts ligand affinity. Proteins, 60: 401-411.
    PubMed  |  
  45. Esteve, E., K. Mabrouk, A. Dupuis, S. Smida-Rezgui and X. Altafaj et al., 2005. Transduction of the scorpion toxin maurocalcine into cells. Evidence that the toxin crosses the plasma membrane. J. Biol. Chem., 280: 12833-12839.
    CrossRef  |  PubMed  |  
  46. Colgin, L., Y. Jia, J.M. Sabatier and G. Lynch, 2005. Blockade of NMDA receptors enhances spontaneous sharp waves in rat hippocampal slices. Neurosci. Lett., 385: 46-51.
  47. Carrega, L., A. Mosbah, G. Ferrat, C. Beeton and N. Andreotti et al., 2005. The impact of the fourth disulfide bridge in scorpion toxins of the alfa-KTx6 sub-family. Proteins, 61: 1010-1023.
    PubMed  |  
  48. Andreotti, N., E. Di Luccio, F. Sampieri, M. De Waard and J.M. Sabatier et al., 2005.. Molecular modeling and docking simulations of scorpion toxins and related analogues on human SKCa2 and SKCa3 channels. Peptides, 26: 1095-1108.
    PubMed  |  
  49. Altafaj, X., W. Cheng, E. Esteve, J. Urbani and D. Grunwald et al., 2005. Maurocalcine and domain A of the II-III loop of the dihydropyridine receptor Cav1.1 subunit share common binding sites on the skeletal ryanodine receptor. J. Biol. Chem., 280: 4013-4016.
    CrossRef  |  PubMed  |  
  50. Visan, V., Z. Fajloun, J.M. Sabatier and S. Grissmer, 2004. Mapping of maurotoxin (MTX) binding sites on hKv1.2, hKv1.3 and hIKCa1 channels. Mol. Pharmacol., 66: 1103-1112.
    PubMed  |  
  51. Visan, V., J.M. Sabatier and S. Grissmer, 2004. Block of maurotoxin and charybdotoxin on human intermediate-conductance calcium-activated potassium channels (hIKCa1). Toxicon, 43 : 973-980.
    PubMed  |  
  52. Regaya, I., T. Pham, N. Andreotti, N. Sauze and L. Carrega et al., 2004. Small conductance calcium-activated K+ channels, SKCa, but not voltage-gated K+ (Kv) channels, are implicated in the antinociception induced by CGS21680, a A2A adenosine receptor agonist. Life Sci., 76: 367-377.
  53. Regaya , I., C. Beeton, G. Ferrat, N. Andreotti and H. Darbon et al., 2004. Evidence for domain-specific recognition of SK and Kv channels by MTX and HsTx1 scorpion toxins. J. Biol. Chem., 279: 55690-55696.
    PubMed  |  
  54. Mouhat, S., B. Jouirou, A. Mosbah, M. De Waard and J.M. Sabatier et al., 2004.. Diversity of folds in animal toxins acting on ion channels. Biochem. J., 378: 717-726.
    Direct Link  |  
  55. Mouhat, S., A. Mosbah, V. Visan, H. Wulff and M. Delepierre et al., 2004. The functional dyad of scorpion toxin Pi1 is not by itself a prerequisite for toxin binding to the voltage-gated Kv1.2 potassium channels. Biochem. J., 377: 25-36.
    Direct Link  |  
  56. M'Barek, S., Z. Fajloun, S. Cestele, C. Devaux and P. Mansuelle et al., 2004. First chemical synthesis of a scorpion alfa-toxin affecting sodium channels: The AaH I toxin of Androctonus australis Hector. J. Peptide Sci., 10: 666-677.
    PubMed  |  
  57. Jouirou, B., S. Mouhat, N. Andreotti, M. De Waard and J.M. Sabatier et al., 2004. Toxin determinants required for interaction with voltage-gated K+ channels. Toxicon, 43: 909-914.
    CrossRef  |  
  58. Jouirou, B., A. Mosbah, V. Visan, S. Grissmer and S. M'Barek et al., 2004. Cobatoxin 1 from Centruroides noxius scorpion venom: Chemical synthesis, 3-D structure in solution, pharmacology and docking on K+ channels. Biochem. J., 377: 37-49.
    PubMed  |  
  59. MBarek, S., I. Lopez-Gonzalez, N. Andreotti, E. di Luccio and V. Visan et al., 2003.. A maurotoxin with constrained standard disulfide bridging-Innovative strategy of chemical synthesis, pharmacology and docking on K+ channels. J. Biol. Chem., 278: 31095-31104.
    Direct Link  |  
  60. M'Barek, S., A. Mosbah, G. Sandoz, P. Mansuelle and Z. Fajloun et al., 2003. Synthesis and characterization of Pi4, a scorpion toxin from Pandinus imperator that acts on K+ channels. Eur. J. Biochem., 270: 3583-3592.
    PubMed  |  
  61. Guijarro, J.I., S. M'Barek, F. Gomez-Lagunas, D. Garnier and H. Rochat et al., 2003. Solution structure of Pi4, a short four-disulfide-bridged scorpion toxin specific of potassium channels. Protein Sci., 12: 1844-1854.
    PubMed  |  
  62. Esteve, E., S. Smida-Rezgui, S. Sarkozi, I. Regaya and L. Chen et al., 2003. Critical amino acid residues determine the binding affinity and the Ca2+ release efficacy of maurocalcine in skeletal muscle cells. J. Biol. Chem., 278: 37822-37831.
    Direct Link  |  
  63. Chen, L., E. Esteve, J.M. Sabatier, M. Ronjat and M. De Waard et al., 2003. Maurocalcine and peptide A stabilize distinct subconductance states of ryanodine receptor type 1 (RyR1) revealing a proportional gating mechanism. J. Biol. Chem., 278: 16095-16106.
    CrossRef  |  
  64. Castle, N.A., D.B. London, C. Creech, Z. Fajloun and J. Stocker et al., 2003. Maurotoxin, a potent inhibitor of intermediate conductance Ca2+-activated potassium channels. Mol. Pharmacol., 63: 409-418.
  65. Geib, S., G. Sandoz, V. Cornet, K. Mabrouk and O. Fund-Saunier et al., 2002. The interaction between the I-II loop and the III-IV loop of Cav2.1 contributes to voltage-dependent inactivation in a β-dependent manner. J. Biol. Chem., 277: 10003-10013.
    PubMed  |  
  66. Fathallah, M., G. Sandoz, K. Mabrouk, S. Geib and J. Urbani et al., 2002.. Modeling of the III-IV loop, a domain involved in calcium channel Cav2.1 inactivation, highlights a structural homology with the gamma subunit of G proteins. Eur. J. Neurosci., 16: 219-228.
    CrossRef  |  
  67. Fajloun, Z., G. Ferrat, E. Carlier, S. M'Barek and I. Regaya et al., 2002. Synthesis, 3-D structure and pharmacology of a reticulated chimera derived from maurotoxin and Tsk scorpion toxins. Biochem. Biophys. Res. Comm., 291: 640-648.
    CrossRef  |  PubMed  |  Direct Link  |  
  68. Di Luccio, E., A. Matavel, S. Opi, I. Regaya and G. Sandoz et al., 2002. Evolution of Maurotoxin conformation and blocking efficacy towards Shaker B channels during the course of folding and oxidation in vitro. Biochem. J., 361: 409-416.
    Direct Link  |  
  69. De Mareuil, J., K. Mabrouk, E. Doria, M. Moulard and S. De Chasteigner et al., 2002. Liposomal encapsulation enhances SPC3 antiviral efficacy against human immunodeficiency virus type 1 infection in human lymphocytes. Antiviral Res., 54: 175-188.
    PubMed  |  
  70. Shakkottai, V.G., I. Regaya, H. Wulff, Z. Fajloun and H. Tomita et al., 2001. Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. J. Biol. Chem., 276: 43145-43151.
    CrossRef  |  PubMed  |  
  71. Ferchichi, M., M. Fathallah, P. Mansuelle, H. Rochat, J.M. Sabatier, M. Manai and K. Mabrouk, 2001. Chemical synthesis, molecular modeling, and antimicrobial activity of a novel bacteriocin, MMFII. Biochem. Biophys. Res. Comm., 289: 13-18.
    CrossRef  |  PubMed  |  Direct Link  |  
  72. Di Luccio, E., D.O. Azulay, I. Regaya, Z. Fajloun and G. Sandoz et al., 2001. Parameters affecting in vitro oxidation/folding of Maurotoxin, a four disulfide-bridged scorpion toxin. Biochem. J., 358: 681-692.
    PubMed  |  
  73. Carlier, E., Z. Fajloun, P. Mansuelle, M. Fathallah and A. Mosbah et al., 2001. Disulfide bridge reorganization induced by proline mutations in Maurotoxin. FEBS Lett., 489: 202-207.
    CrossRef  |  Direct Link  |  
  74. Beeton, C., J. Barbaria, P. Giraud, J. Devaux and A.M. Benoliel et al., 2001. Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation. J. Immunol., 166: 936-944.
    PubMed  |  
  75. Beeton, C., J. Barbaria, A.M. Benoliel, P. Giraud and M. Gola et al., 2001. Kaliotoxin, a voltage-gated potassium channel blocker, inhibits encephalitogenic T cell activation. J. Immunol., 166: 936-944.
  76. Mosbah, A., R. Kharrat, Z. Fajloun, G. Renisio and E. Blanc et al., 2000. A new fold in the scorpion toxin family, associated with an activity on a ryanodine-sensitive calcium channel. Proteins, 40: 436-442.
    PubMed  |  
  77. Lecomte, C., R. Ben Khalifa, M.F. Martin-Eauclaire, R. Kharrat and M. El Ayeb et al., 2000. Maurotoxin and the Kv1.1 channel: Voltage-dependent binding upon enantiomerization of the scorpion toxin disulfide bridge Cys31-Cys34. J. Peptide Res., 55: 246-254.
    CrossRef  |  PubMed  |  Direct Link  |  
  78. Fajloun, Z., R. Kharrat, L. Chen, C. Lecomte and E. di Luccio et al., 2000. Chemical synthesis and characterization of Maurocalcine, a scorpion toxin that activates Ca2+ release channel/ryanodine receptors. FEBS Lett., 469: 179-185.
    CrossRef  |  Direct Link  |  
  79. Fajloun, Z., G. Ferrat, C. Carlier, M. Fathallah and C. Lecomte et al., 2000. Synthesis, 1H-NMR structure and activity of a three disulfide-bridged Maurotoxin analog designed to restore the consensus motif of scorpion toxins. J. Biol. Chem., 275: 13605-13612.
    CrossRef  |  Direct Link  |  
  80. Fajloun, Z., E. Carlier, C. Lecomte, S. Geib and E. di Luccio et al., 2000. Chemical synthesis and characterization of Pi1, a scorpion toxin from Pandinus imperator active on K+ channels. Eur. J. Biochem., 267: 5149-5155.
    CrossRef  |  PubMed  |  Direct Link  |  
  81. Fajloun, Z., A. Mosbah, E. Carlier, P. Mansuelle and G. Sandoz et al., 2000. Maurotoxin versus Pi1/HsTx1 scorpion toxins: Toward new insights in the understanding of their distinct disulfide bridge patterns. J. Biol. Chem., 275: 39394-39402.
    CrossRef  |  PubMed  |  Direct Link  |  
  82. Carlier, E., S. Geib, M. De Waard, V. Avdonin and T. Hoshi et al., 2000. Effect of maurotoxin, a four disulfide-bridged toxin from the chactoid scorpion Scorpio maurus, on Shaker K+ channels. J. Peptide Res., 55: 419-427.
    CrossRef  |  Direct Link  |  
  83. Carlier, E., M. de Waard, K. Mabrouk, Z. Fajloun, H. Rochat, J.M. Sabatier and M. Moulard, 2000. Ion channel activation by SPC3, a peptide derived from the HIV-1 gp120 V3 loop. J. Peptide Res., 56: 427-437.
    CrossRef  |  PubMed  |  Direct Link  |  
  84. Bichet, D., C. Lecomte, J.M. Sabatier, R. Felix and M. De Waard, 2000. Reversibility of the Ca2+ channel α1-β subunit interaction. Biochem. Biophys. Res. Commun., 277: 729-735.
    CrossRef  |  Direct Link  |  
  85. Avdonin, V., B. Nolan, J.M. Sabatier, M. de Waard and T. Hoshi, 2000. Mechanisms of maurotoxin action on Shaker potassium channels. Biophys. J., 79: 776-787.
    CrossRef  |  Direct Link  |  
  86. Avdonin, V., B. Nolan, J.M. Sabatier, M. De Waard and T. Hoshi et al., 2000. Biophysical and molecular mechanisms of the action of Maurotoxin on Shaker potassium channels. Biophys. J., 79: 776-787.
  87. Moulard, M., K. Mabrouk, I. Martin, H. Rochat, J. Van Rietschoten and J.M. Sabatier, 1999. V3 loop-derived peptide SPC3 inhibits infection of CD4- negative and Galactosylceramide- negative cells by LAV-2/B. J. Peptide Res., 53: 647-655.
    CrossRef  |  
  88. Lecomte, C., G. Ferrat, Z. Fajloun, J. Van Rietschoten and H. Rochat et al., 1999. Chemical synthesis and structure-activity of Ts K, a novel scorpion toxin acting on apamin-sensitive SK channel. J. Peptide Res., 54: 369-376.
    CrossRef  |  PubMed  |  Direct Link  |  
  89. Darbon, H., E. Blanc and J.M. Sabatier, 1999. Three-dimensional structure of scorpion toxins: Towards a new model of interaction with potassium channels. Perspect. Drug Discovery Des., 15/16: 40-60.
    CrossRef  |  
  90. Rochat, H., R. Kharrat, J.M. Sabatier, P. Mansuelle and M. Crest et al., 1998. Maurotoxin, a four disulfide bridges scorpion toxin acting on K+ channels. Toxicon, 36: 1609-1611.
    CrossRef  |  PubMed  |  Direct Link  |  
  91. Lecomte, C., J.M. Sabatier, J. van Rietschoten and H. Rochat, 1998. Synthetic peptides as tools to investigate the structure and pharmacology of potassium channel-acting short-chain scorpion toxins. Biochimie, 80: 151-154.
    CrossRef  |  PubMed  |  Direct Link  |  
  92. Barbouche, R., R. Miquelis, J.M. Sabatier and E. Enouillet, 1998. SPC3, an anti-HIV peptide construct derived from the viral envelope, binds and enters HIV target cells. J. Peptide Sci., 4: 479-485.
    PubMed  |  
  93. Barbouche, R., J.M. Sabatier and E. Fenouillet, 1998. An anti-HIV peptide construct derived from the cleavage region of the Env precursor acts on Env fusogenicity through the presence of a functional cleavage sequence. Virology, 247: 137-143.
    CrossRef  |  PubMed  |  
  94. Barbouche, R., E. Fenouillet, M.J. Papandreou, M.P. Kieny and J.M. Sabatier, 1998. Properties of HIV envelope expressed in the presence of SPC3, an Env-derived peptide drug under phase II clinical trials. J. Peptide Res., 52: 283-288.
    PubMed  |  
  95. Zenouaki, I., R. Kharrat, J.M. Sabatier, C. Devaux and H. Karoui et al., 1997. In vivo protection against Androctonus australis hector scorpion toxin and venom by immunization with a synthetic analog of toxin II. Vaccine, 15: 187-194.
    CrossRef  |  PubMed  |  
  96. Devaux, C., O. Clot-Faybesse, M. Juin, K. Mabrouk, J.M. Sabatier and H. Rochat, 1997. Monoclonal antibodies neutralizing the toxin II from Androctonus australis Hector scorpion venom: Usefulness of a synthetic, non-toxic analog. FEBS 421: 456-460.
    CrossRef  |  Direct Link  |  
  97. Calabro, V., J.M. Sabatier, E. Blanc, C. Lecomte, J. Van Rietschoten and H. Darbon, 1997. Differential involvement of disulfide bridges on the folding of a scorpion toxin. J. Peptide Res., 50: 39-47.
    PubMed  |  
  98. Blanc, E., J.M. Sabatier, R. Kharrat, S. Meunier, M. El Ayeb, J. Van Rietschoten and H. Darbon, 1997. Solution structure of Maurotoxin, a scorpion toxin from Scorpio maurus, with high affinity for voltage-gated potassium channels. Proteins, 29: 321-333.
    PubMed  |  
  99. Blanc, E., C. Lecomte, J. van Rietschoten, J.M. Sabatier and H. Darbon, 1997. Solution structure of TsKapa, a charybdotoxin-like scorpion toxin from Tityus serrulatus with high affinity for apamin-sensitive Ca2+-activated K+ channels. Proteins, 29: 359-369.
    PubMed  |  
  100. Sabatiera, J.M., K. Mabrouka, M. Moulard, H. Rochat, J. Van Rietschoten and E. Fenouillet, 1996. Anti-HIV activity of multibranched peptide constructs derived either from the cleavage sequence or from the transmembrane domain (gp41) of the human immunodeficiency virus type 1 envelope. Virology, 223: 406-408.
    CrossRef  |  Direct Link  |  
  101. Sabatier, J.M., C. Lecomte, K. Mabrouk, H. Darbon and R. Oughideni et al., 1996. Synthesis and characterization of Leiurotoxin I analogs lacking one disulfide bridge: Evidence that disulfide pairing 3-21 is not required for full toxin activity. J. Biochem., 35: 10641-10647.
    CrossRef  |  Direct Link  |  
  102. Kharrat, R., K. Mabrouk, M. Crest, H. Darbon and R. Oughideni et al., 1996. Chemical synthesis and characterization of maurotoxin, a short scorpion toxin with four disulfide bridges that acts on K+ channels. Eur. J. Biochem., 242: 491-498.
    CrossRef  |  Direct Link  |  
  103. Fantini, J., N. Yahi, K. Mabrouk, H. Rochat, J. Van Rietschoten and J.M. Sabatier, 1996. V3 loop-derived multibranched peptides as inhibitors of HIV infection in CD4+ and CD4- cells. Perspect. Drug Discov. Des., 5: 243-250.
    CrossRef  |  Direct Link  |  
  104. Yahi, N., J.M. Sabatier, S. Baghdiguian, F.G. Scarano and J. Fantini et al., 1995. Synthetic multimeric peptides derived from the principal neutralization domain (V3 loop) of HIV-1 gp120 bind to galactosylceramide and block HIV-1 infection in a human CD4-negative mucosal epithelial cell line. J. Virol., 69: 320-325.
    PubMed  |  
  105. Yahi, N., J. Fantini, S. Baghdiguian, K. Mabrouk and H. Rochat et al., 1995. SPC3, a synthetic peptide derived from the V3 domain of HIV-1 gp120, inhibits HIV-1 entry into CD4+ and CD4- cells by two distinct mechanisms. Proc. Natl. Acad. Sci. USA., 92: 4867-4871.
    Direct Link  |  
  106. Sabatier, J.M., S. Baghdiguian, N. Yahi, H. Rochat and J. Van Rietschoten et al., 1995. SPC3, a nontoxic peptide inhibitor of HIV infection. In vitro Cell. Dev. Biol. Anim., 31: 415-418.
    PubMed  |  
  107. Inisan, A.G., S. Meunier, O. Fedelli, M. Altbach and V. Fremont et al., 1995. Structure-activity relationship study of a scorpion toxin with high affinity for apamin-sensitive potassium channels by means of the solution structure of analogues. Int. J. Peptide Protein Res., 45: 441-450.
    PubMed  |  
  108. Fantini, J., S. Baghdiguian, J.M. Sabatier and N. Yahi, 1995. Role des glycolipides dans linfection des cellules par le virus du SIDA. OCL. Oleagineux Corps Gras Lipides, 2: 104-107.
    Direct Link  |  
  109. Yahi, N., J.M. Sabatier, P. Nickel, K. Mabrouk and F. Gonzalez-Scarano et al., 1994. Suramin inhibits binding of the V3 region of human immunodeficiency virus type 1 envelope glycoprotein gp120 to galactosyl ceramide (GalCer). J. Biol. Chem., 269: 24349-24353.
    Direct Link  |  
  110. Yahi, N., J. Fantini, K. Mabrouk, J. van Rietschoten and H. Rochat et al., 1994. Evaluation of multi-branched peptides as inhibitors of HIV infection. Lett. Pept. Sci., 1: 17-24.
    CrossRef  |  
  111. Yahi, N., J. Fantini, K. Mabrouk, C. Tamalet and P. De Micco et al., 1994. Multi-branched V3 peptides inhibit human immunodeficiency virus infection in human lymphocytes and macrophages. J. Virol., 68: 5714-5720.
    PubMed  |  
  112. Sabatier, J.M., V. Fremont, K. Mabrouk, M. Crest and H. Darbon et al., 1994. Leiurotoxin I, a scorpion toxin specific for Ca2+-activated K+ channels: Structure-activity analysis using synthetic analogs. Int. J. Pept. Protein Res., 43: 486-495.
  113. Fantini, J., N. Yahi, K. Mabrouk, J. Van Rietschoten and H. Rochat et al., 1994. Multi-branched V3 peptides as HIV inhibitors. Curr. Top. Pept. Protein Res., 1: 11-24.
  114. Benjouad, A., E. Fenouillet, J.C. Gluckman and J.M. Sabatier, 1994. Multi-Branched Peptide Constructs (MBPC) of the V3 loop of envelope glycoprotein gp120 inhibit human immunodeficiency virus-induced syncytium formation. Antiviral Chem. Chemother., 5: 195-196.
    Direct Link  |  
  115. Tordjman, M., G. Fontan, V. Rabillon, J. Martin and C. Trep et al., 1993. Characterization of minor and major antigenic regions within the hepatitis B virus nucleocapsid (HBcAg). J. Med.Virol., 41: 221-229.
    CrossRef  |  
  116. Sabatier, J.M., H. Zerrouk, H. Darbon, K. Mabrouk and A. Benslimane et al., 1993. P05, a new leiurotoxin I scorpion toxin: Synthesis and structure-activity relationships of the alfa-amidated analog, a ligand of Ca2+-activated K+ channels with increased affinity. Biochemistry, 32: 2763-2770.
    Direct Link  |  
  117. Meunier, S., J.M. Bernassau, J.M. Sabatier, M.F. Martin-Eauclaire and J. van Rietschoten et al., 1993. Solution structure of P05-NH2, a scorpion toxin analog with high affinity for apamin-sensitive potassium channel. Biochemistry, 32: 11969-11976.
    PubMed  |  
  118. Fantini, J., N. Yahi, K. Mabrouk, J. Van Rietschoten and H. Rochat et al., 1993. Multi-branched peptides based on the HIV-1 V3 loop consensus motif inhibit HIV-1 and HIV-2 infection in CD4+ and CD4- cells. Acad. Sci., 316: 1381-1387.
    PubMed  |  
  119. Benjouad, A., K. Mabrouk, M. Moulard, J.C. Gluckman and H. Rochat et al., 1993. Cytotoxic effect on lymphocytes of Tat from human immunodeficiency virus type 1. FEBS, 319: 119-124.
    PubMed  |  
  120. Sabatier, J.M., J. Van Rietschoten, C. Granier and E. Bahraoui, 1991. La proteine Nef du virus HIV-1: Facteur de controverse. Med. Sci., 7: 62-65.
  121. Sabatier, J.M., E. Vives, K. Mabrouk, A. Benjouad and H. Rochat et al., 1991. Evidence for neurotoxic activity of Tat from human immunodeficiency virus type 1. J. Virol., 65: 961-967.
    PubMed  |  
  122. Mabrouk, K., R.J. van, E. Vives, H. Darbon and H. Rochat et al., 1991. Lethal neurotoxicity in mice of the basic domains of HIV and SIV Rev proteins: Study of these regions by circular dichroism. FEBS, 289: 13-17.
    PubMed  |  
  123. Sabatier, J.M., G. Fontan, E. Loret, K. Mabrouk and H. Rochat et al., 1990. Large fragments of Nef-protein and gp110 envelope glycoprotein from HIV-1: Synthesis, CD analysis and immunoreactivity. Int. J. Pept. Protein Res., 35: 63-72.
    PubMed  |  
  124. Bahraoui, E., M. Yagello, J.N. Billaud, J.M. Sabatier and B. Guy et al., 1990. Immunogenicity and antigenicity of the Human Immunodeficiency Virus (HIV) recombinant nef gene product. Mapping of T- and B-cell epitopes in immunized chimpanzees. AIDS Res. Hum. Retrovir., 6: 1087-1098.
  125. Bahraoui, E., A. Benjouad, J.M. Sabatier, J.P. Allain and Y. Laurian et al., 1990. Relevance of anti-Nef antibodies detection as an early serological marker of HIV infection. Blood, 76: 257-264.
    Direct Link  |  
  126. Sabatier, J.M., B. Clerget, G. Fontan, E. Fenouillet and C. Granier et al., 1989. Use of synthetic peptides for the detection of antibodies against the Nef regulating protein in sera of HIV-infected patients. AIDS, 3: 215-220.
    PubMed  |  
  127. Grandas, A., F. Albericio, E. Pedroso, E. Giralt and J.M. Sabatier et al., 1989. Convergent solid phase peptide synthesis VII. Good yields in the coupling of protected segments on a solid support. Tetrahedron, 45: 4637-4648.
    CrossRef  |  
  128. Goyard, S., C. Orlando, J.M. Sabatier, E. Labruyere and J. D'Alayer et al., 1989. Identification of a common domain in calmodulin-activated eukaryotic and bacterial adenylate cyclases. Biochemistry, 28: 1964-1967.
    PubMed  |  
  129. Bahraoui, E., B. Clerget, C. Granier, J. van Rietschoten and J.M. Sabatier et al., 1989. Accessibility of the highly conserved amino- and carboxy-terminal regions from HIV-1 external envelope glycoprotein. AIDS Res. Hum. Retrovir., 5: 451-463.
    PubMed  |  
  130. Sabatier, J.M., M. Tessier-Rochat, C. Granier, J. Van Rietschoten and E. Pedroso et al., 1987. Convergent solid phase peptide synthesis VI: Syntheses by the Fmoc-amino acids with a modified protocol of two protected segments: Sequence 5-17 and 18-31 of the neurotoxin II of the scorpion Androctonus australis Hector. Tetrahedron, 43: 5973-5980.
    Direct Link  |  
  131. Sabatier, J.M., H. Darbon, P. Fourquet, H. Rochat and J. Van Rietschoten et al., 1987. Reduction and reoxidation of the neurotoxin II from the scorpion Androctonus australis Hector. Int. J. Pept. Protein Res., 30: 125-134.
    PubMed  |  
  132. Trifilieff, E., B. Luu, J.L. Nussbaum, M.A. Espinosa de los and J.M. Sabatier et al., 1986. A specific immunological probe for the major myelin proteolipid; Confirmation of a deletion in DM 20. FEBS, 198: 235-239.
    PubMed  |