Hi, I am Michael Schnekenburger, My LiveDNA is 33.6257
 
   
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Dr. Michael Schnekenburger
 
Highest Degree: Ph.D. in Cellular and Molecular Biology from University of Reims-Champagne-Ardenne, France
 
Institute: Laboratory of Molecular and Cellular Biology of Cancer, Luxembourg
 
Area of Interest: Molecular Sciences
  •   Tumorigenesis
  •   DNA Methylation
  •   Histone Modifications
  •   Epigenetic Modulators
 
URL: http://livedna.org/33.6257
 
My SELECTED Publications
1:   Blasius, R., A. Duvoix, F. Morceau, M. Schnekenburger and S. Delhalle et al., 2004. Curcumin stability and its effect on GSTP1-1 mRNA expression in K562 cells. Ann. NY Acad. Sci., 1030: 441-448.
2:   Cerella, C., C. Sobolewski, S. Chateauvieux, E. Henry and M. Schnekenburger et al., 2011. COX-2 inhibitors block chemotherapeutic agent-induced apoptosis prior to commitment in hematopoietic cancer cells. Biochem. Pharmacol., 82: 1277-1290.
PubMed  |  
3:   Charlet, J., M. Schnekenburger, K.W. Brown and M. Diederich, 2012. DNA demethylation increases sensitivity of neuroblastoma cells to chemotherapeutic drugs. Biochem. Pharmacol., 83: 858-865.
PubMed  |  
4:   Chateauvieux, S., S. Eifes, F. Morceau, M. Schnekenburger, E. Henry, M. Dicato and M. Diederich, 2011. Valproic Acid perturbs hematopoietic homeostasis by inhibition of erythroid differentiation and activation of the myelo-monocytic pathway via inhibition of GATA-1 and activation of PU.1. Biochem. Pharmacol., 81: 498-509.
PubMed  |  
5:   Delhalle, S., A. Duvoix, M. Schnekenburger, F. Morceau, M. Dicato and M. Diederich, 2003. An introduction to the molecular mechanisms of apoptosis. Ann. NY Acad. Sci., 1010: 1-8.
PubMed  |  
6:   Duvoix, A., F. Morceau, M. Schnekenburger, S. Delhalle, M.M. Galteau, M. Dicato and M. Diederich, 2003. Curcumin-induced cell death in two leukemia cell lines: K562 and Jurkat. Ann. NY Acad. Sci., 101: 389-392.
PubMed  |  
7:   Duvoix, A., F. Morceau, S. Delhalle, M. Schmitz and M. Schnekenburger et al., 2003. Induction of apoptosis by curcumin: Mediation by glutathione S-transferase P1-1 inhibition. Biochem. Pharmacol., 66: 1475-1483.
PubMed  |  
8:   Duvoix, A., M. Schmitz, M. Schnekenburger, M. Dicato, F. Morceau, M.M. Galteau and M. Diederich, 2003. Transcriptional regulation of glutathione S-transferase P1-1 in human leukemia. Biofactors, 17: 131-138.
PubMed  |  Direct Link  |  
9:   Duvoix, A., M. Schnekenburger, S. Delhalle, R. Blasius and P. Borde-Chiche et al., 2004. Expression of glutathione S-transferase P1-1 in leukemic cells is regulated by inducible AP-1 binding. Cancer Lett., 216: 207-219.
PubMed  |  
10:   Duvoix, A., R. Blasius, S. Delhalle, M. Schnekenburger and F. Morceau et al., 2005. Chemopreventive and therapeutic effects of curcumin. Cancer Lett., 223: 181-190.
CrossRef  |  PubMed  |  Direct Link  |  
11:   Duvoix, A., S. Delhalle, R. Blasius, M. Schnekenburger and F. Morceau et al., 2004. Effect of chemopreventive agents on glutathione S-transferase P1-1 gene expression mechanisms via activating protein 1 and nuclear factor kappaB inhibition. Biochem. Pharmacol., 68: 1101-1111.
PubMed  |  
12:   El Amrani, M., D. Lai, A. Debbab A.H. Aly and K. Siems et al., 2013. Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum. J. Nat. Prod., 77: 49-56.
CrossRef  |  Direct Link  |  
13:   Folmer, F., B. Orlikova, M. Schnekenburger, M. Dicato and M. Diederich, 2010. Naturally occurring regulators of histone acetylation/deacetylation. Curr. Nutr. Food Sci., 6: 78-99.
Direct Link  |  
14:   Grandjenette, C., M. Schnekenburger, F. Morceau, F. Mack and K. Wiechmann et al., 2015. Dual induction of mitochondrial apoptosis and senescence in chronic myelogenous leukemia by myrtucommulone A. Anti-Cancer Agents Med. Chem. (Formerly Curr. Med. Chem.-Anti-Cancer Agents), 15: 363-373.
Direct Link  |  
15:   Grandjenette, C., M. Schnekenburger, T. Karius, J. Ghelfi and A. Gaigneaux et al., 2014. 5-aza-2'-deoxycytidine-mediated c-myc Down-regulation triggers telomere-dependent senescence by regulating human telomerase reverse transcriptase in chronic myeloid leukemia. Neoplasia, 16: 511-528.
CrossRef  |  Direct Link  |  
16:   Juncker, T., C. Cerella, M.H. Teiten, F. Morceau and M. Schumacher et al., 2011. UNBS1450, a steroid cardiac glycoside inducing apoptotic cell death in human leukemia cells. Biochem. Pharmacol., 81: 13-23.
PubMed  |  
17:   Karius, T., M. Schnekenburger, J. Gelfi, J. Walter, M. Dicato and M. Diederich, 2011. Reversible epigenetic fingerprint-mediated glutathione-S-transferase P1 gene silencing in human leukemia cell lines. Biochem. Pharmacol., 81: 1329-1342.
PubMed  |  
18:   Karius, T., M. Schnekenburger, M. Dicato and M. Diederich, 2012. MicroRNAs in cancer management and their modulation by dietary agents. Biochem. Pharmacol., 83: 1591-1601.
CrossRef  |  PubMed  |  
19:   Koprinarova, M., M. Schnekenburger and M. Diederich, 2016. Role of histone acetylation in cell cycle regulation. Curr. Top. Med. Chem., 16: 732-744.
Direct Link  |  
20:   Kurita, H., M. Schnekenburger, J.L. Ovesen, Y. Xia and A. Puga, 2014. The Ah receptor recruits IKKα to its target binding motifs to phosphorylate serine-10 in histone H3 required for transcriptional activation. Toxicol. Sci., 139: 121-132.
CrossRef  |  Direct Link  |  
21:   Morceau, F., A. Duvoix, S. Delhalle, M. Schnekenburger, M. Dicato and M. Diederich, 2004. Regulation of glutathione S-transferase P1-1 gene expression by NF-kappaB in tumor necrosis factor alpha-treated K562 leukemia cells. Biochem. Pharmacol., 67: 1227-1238.
PubMed  |  
22:   Morceau, F., M. Schnekenburger, M. Dicato and M. Diederich, 2004. GATA-1: Friends, brothers and co-workers. Ann. NY Acad. Sci., 1030: 537-554.
PubMed  |  
23:   Morceau, F., M. Schnekenburger, R. Blasius, I. Buck, M. Dicato and M. Diederich, 2006. Tumor necrosis factor alpha inhibits aclacinomycin A-induced erythroid differentiation of K562 cells via GATA-1. Cancer Lett., 240: 203-212.
PubMed  |  
24:   Nunes, M.J., I. Milagre, M. Schnekenburger, M.J. Gama, M. Diederich and E. Rodrigues, 2010. SP proteins have a critical role in histone deacvetylase inhibitor-mediated derepression of CYP46A1 gene transcription. J. Neurochem., 113: 418-431.
Direct Link  |  
25:   Orlikova, B., M. Schnekenburger, M. Zloh, M. Diederich and D. Tasdemir, 2012. Natural chalcones as dual inhibitors of HDAC and NF-κB. Oncol. Rep., 28: 797-805.
PubMed  |  
26:   Ovesen, J.L., M. Schnekenburger and A. Puga, 2011. Aryl hydrocarbon receptor ligands of widely different toxic equivalence factors induce similar histone marks in target gene chromatin. Toxicol. Sci., 121: 123-131.
PubMed  |  
27:   Peng, L., C.N. Mayhew, M. Schnekenburger, E.S. Knudsen and A. Puga, 2008. Repression of Ah receptor and induction of transforming growth factor-β genes in DEN-induced mouse liver tumors. Toxicolgy, 246: 242-247.
PubMed  |  
28:   Poplineau, M., C. Doliwa, M. Schnekenburger, F. Antonicelli, M. Diederich, A. Trussardi-Regnier and J. Dufer, 2013. Epigenetically-induced changes in nuclear textural patterns affect gelatinase expression in human fibrosarcoma cells. Cell. Prolif., 46: 127-136.
PubMed  |  
29:   Poplineau, M., M. Schnekenburger, J. Dufer, A. Kosciarz and S. Brassart‐Pasco et al., 2015. The DNA hypomethylating agent, 5‐aza‐2'‐deoxycytidine, enhances tumor cell invasion through a transcription-dependent modulation of MMP-1 expression in human fibrosarcoma cells. Mol. Carcinogenesis, 54: 24-34.
CrossRef  |  Direct Link  |  
30:   Puga, A. and M. Schnekenburger, 2009. Epigenetic regulation of drug metabolism genes. Drug Metab. Rev., 41: 8-9.
31:   Reichard, J.F., M. Schnekenburger and A. Puga, 2007. Long term low-dose arsenic exposure induces loss of DNA methylation. Biochem. Biophys. Res. Commun., 352: 188-192.
PubMed  |  
32:   Reuter, S., M. Schnekenburger, S. Cristofanon, I. Buck and M.H. Teiten et al., 2009. Tumor necrosis factor alpha induces gamma-glutamyltransferase expression via nuclear factor-κB in cooperation with Sp1. Biochem. Pharmacol., 77: 397-411.
PubMed  |  
33:   Rotili, D., D. Tarantino, B. Marrocco, C. Gros and V. Masson et al., 2014. Properly substituted quinazoline analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity. PLoS One, Vol. 2014. 10.1371/journal.pone.0096941.
CrossRef  |  
34:   Schnekenburger, M. and M. Diederich, 2011. Omic technologies in human disease: Extending the network of epigenetic control. Epigenomics, 3: 539-541.
PubMed  |  
35:   Schnekenburger, M. and M. Diederich, 2012. Epigenetics offer new horizons for colorectal cancer prevention. Curr. Colorectal. Cancer Rep., 8: 66-81.
PubMed  |  
36:   Schnekenburger, M. and M. Diederich, 2014. Modulation of epigenetic mechanisms for anti-cancer intervention-New challenges and perspectives. Austin J. Genet. Genomic Res., 1: 1-2.
37:   Schnekenburger, M. and M. Diederich, 2016. DNA methylation and demethylation mechanisms as therapeutic targets? Curr. Top. Med. Chem., 16: 807-808.
38:   Schnekenburger, M., C. Florean, C. Grandjenette and M. Diederich, 2015. Editorial: Novel pharmaceutical approaches by natural compound-derived epigenetic regulators: epigenetic readers, writers and erasers as therapeutic targets. Curr. Top. Med. Chem., 16: 677-679.
Direct Link  |  
39:   Schnekenburger, M., C. Florean, C. Grandjenette, M. Dicato and M. Diederich, 2011. Epigenomics of leukemia: From mechanisms to therapeutic applications. Epigenomics, 3: 581-609.
PubMed  |  
40:   Schnekenburger, M., C. Florean, M. Dicato and M. Diederich, 2016. Epigenetic alterations as a universal feature of cancer hallmarks and a promising target for personalized treatments. Curr. Top. Med. Chem., 16: 745-776.
Direct Link  |  
41:   Schnekenburger, M., C. Grandjenette, J. Gelfi, T. Karius, B. Foliguet, M. Dicato and M. Diederich, 2011. Sustained exposure to the DNA demethylating agent, 2'-deoxy-5-azacytidine, leads to apoptotic cell death in chronic myeloid leukemia by promoting differentiation, senescence and autophagy. Biochem. Pharmacol., 81: 364-378.
PubMed  |  
42:   Schnekenburger, M., F. Morceau, A. Duvoix, S. Delhalle, C. Trentesaux, M. Dicato and M. Diederich, 2003. Expression of glutathione S-transferase P1-1 in differentiating K562: Role of GATA-1. Biochem. Biophys. Res. Commun., 311: 815-821.
PubMed  |  
43:   Schnekenburger, M., F. Morceau, A. Duvoix, S. Delhalle, C. Trentesaux, M. Dicato and M. Diederich, 2004. Increased glutathione S-transferase P1-1 expression by mRNA stabilization in hemin-induced differentiation of K562 cells. Biochem. Pharmacol., 68: 1269-1277.
PubMed  |  
44:   Schnekenburger, M., F. Morceau, E. Henry, R. Blasius, M. Dicato, C. Trentesaux and M. Diederich, 2006. Transcriptional and post-transcriptional regulation of glutathione S-transferase P1 expression during butyric acid-induced differentiation of K562 cells. Leuk Res., 30: 561-568.
PubMed  |  
45:   Schnekenburger, M., G. Talaska and A. Puga, 2007. Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activation. Mol. Cell Biol., 27: 7089-7101.
PubMed  |  
46:   Schnekenburger, M., L. Peng and A. Puga, 2007. HDAC1 bound to the Cyp1a1 promoter blocks histone acetylation associated with Ah receptor-mediated transactivation. Biochim. Biophys. Acta, 1769: 569-578.
PubMed  |  
47:   Schnekenburger, M., M. Dicato and M. Diederich, 2014. Epigenetic modulators from The Big Blue: A treasure to fight against cancer. Cancer Lett., 351: 182-197.
CrossRef  |  Direct Link  |  
48:   Schnekenburger, M., M. Dicato and M. Diederich, 2014. Plant-derived epigenetic modulators for cancer treatment and prevention. Biotechnol. Adv., 32: 1123-1132.
CrossRef  |  Direct Link  |  
49:   Schnekenburger, M., M.A. Sartor, J.L. Marlowe, J.F. Reichard and Y. Wang et al., 2009. Genomewide analysis of aryl hydrocarbon receptor binding targets reveals an extensive array of gene clusters that control morphogenetic and developmental programs. Environ. Health Perspect., 117: 1139-1146.
PubMed  |  
50:   Schnekenburger, M., T. Karius, C. Cerella and M. Diederich, 2011. Targeting inflammatory cell signaling mechanisms: A promising road to new therapeutic agents in chemoprevention and cancer therapy. J. Exp. Ther. Onco., 9: 1-4.
PubMed  |  
51:   Schumacher, M., T. Juncker, M. Schnekenburger, F. Gaascht and M. Diederich, 2011. Natural compounds as inflammation inhibitors. Genes Nutr., 6: 89-92.
Direct Link  |  
52:   Seidel, C., C. Florean, M. Schnekenburger and M. Diederich, 2012. Chromatin modifying agents in anticancer therapy. Biochimie, 94: 2264-2279.
CrossRef  |  Direct Link  |  
53:   Seidel, C., M. Schnekenburger, A. Mazumder, M.H. Teiten, G. Kirsch, M. Dicato and M. Diederich, 2016. 4-Hydroxybenzoic acid derivatives as HDAC6-specific inhibitors modulating microtubular structure and HSP90α chaperone activity against prostate cancer. Biochem. Pharmacol., 99: 31-52.
CrossRef  |  Direct Link  |  
54:   Seidel, C., M. Schnekenburger, C. Zwergel, F. Gaascht and A. Mai et al., 2014. Novel inhibitors of human histone deacetylases: Design, synthesis and bioactivity of 3-alkenoylcoumarines. Bioorganic Med. Chem. Lett., 24: 3797-3801.
CrossRef  |  Direct Link  |  
55:   Seidel, C., M. Schnekenburger, M. Dicato and M. Diederich, 2012. Histone deacetylase modulators provided by mother nature. Genes Nutr., 7: 357-367.
PubMed  |  
56:   Seidel, C., M. Schnekenburger, M. Dicato and M. Diederich, 2014. Antiproliferative and proapoptotic activities of 4-hydroxybenzoic acid-based inhibitors of histone deacetylases. Cancer Lett., 343: 134-146.
CrossRef  |  Direct Link  |  
57:   Seidel, C., M. Schnekenburger, M. Dicato and M. Diederich, 2015. Histone deacetylase 6 in health and disease. Epigenomics, 7: 103-118.
CrossRef  |  Direct Link  |  
58:   Talhi, O., M. Schnekenburger, J. Panning, D.G. Pinto and J.A. Fernandes et al., 2014. Bis (4-hydroxy-2H-chromen-2-one): Synthesis and effects on leukemic cell lines proliferation and NF-κB regulation. Bioorganic Med. Chem., 22: 3008-3015.
CrossRef  |  Direct Link  |  
59:   Trecul, A., F. Morceau, A. Gaigneaux, M. Schnekenburger, M. Dicato and M. Diederich, 2014. Valproic acid regulates erythro-megakaryocytic differentiation through the modulation of transcription factors and microRNA regulatory micro-networks. Biochem. Pharmacol., 92: 299-311.
CrossRef  |  Direct Link  |  
60:   Valente, S., Y. Liu, M. Schnekenburger, C. Zwergel and S. Cosconati et al., 2014. Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells. J. Med. Chem., 57: 701-713.
CrossRef  |  Direct Link  |