Hi, I am Marc Poirot, My LiveDNA is 33.6334
 
   
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Dr. Marc Poirot
 
Highest Degree: Ph.D. in Chemistry from Universite Paul Sabatier, Toulouse, France
 
Institute: Institut National de la Sante et de la Recherche Medicale, France
 
Area of Interest: Chemistry
  •   Drug Design Discovery
  •   Pharmacology
  •   Medicinal Chemistry
  •   Cholesterol Metabolism
 
URL: http://livedna.org/33.6334
 
My SELECTED Publications
1:   Betbeder, D., J.J. Perie, T. Baltz, M. Poirot and J.C. Faye, 1993. Characterization of a benzyl-phenoxy-ethanamine binding protein in Trypanosoma equiperdum and the possible relation between binding affinity and trypanocidal activity. Mol. Biochem. Parasitol., 58: 311-316.
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2:   Brillouet, S., O. Caselles, L.O. Dierickx, B. Mestre and J. Nalis et al., 2007. Preclinical evaluation of new radioligand of cholecystokinin/gastrin receptors in endocrine tumors xenograft nude mice. Nucl. Inst. Meth. Phys. Res. Sect. A: Accelerat. Spectromet. Detect. Assoc. Equip., 571: 160-164.
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3:   Brillouet, S., S. Dorbes, F. Courbon, C. Picard and J.P. Delord et al., 2010. Development of a new radioligand for cholecystokinin receptor subtype 2 scintigraphy: From molecular modeling to In vivo evaluation. Bioorg. Med. Chem., 18: 5400-5412.
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4:   Brillouet, S., S. Dorbes, S. Silvente-Poirot, B. Mestre-Voegtle, C. Picard, M. Poirot and F. Courbon, 2010. Peptidic targeting in nuclear oncology: Interest of molecular modelling. Med. Nul. Imagerie Function.Metabol., 34: 289-294.
5:   Chailleux, C., M. Poirot, F. Mesange, F. Bayard and J.C. Faye, 1994. Characterization of the membranous antiestrogen binding protein: I. Partial purification of the protein in its active state. J. Recept. Res., 14: 23-35.
PubMed  |  Direct Link  |  
6:   Chapuy-Regaud, S., C. Subra, M. Requena, P. de Medina and S. Amara et al., 2013. Progesterone and a phospholipase inhibitor increase the endosomal bis(monoacylglycero)phosphate content and block HIV viral particle intercellular transmission. Biochimie, 95: 1677-1688.
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7:   Dalenc, F., C. Giamarchi, M. Petit, M. Poirot, G. Favre and J.C. Faye, 2005. Farnesyl-transferase inhibitor R115,777 enhances tamoxifen inhibition of MCF-7 cell growth through estrogen receptor dependent and independent pathways. Breast Cancer Res., 7: R1159-R1167.
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8:   Dalenc, F., M. Poirot and S. Silvente-Poirot, 2015. Dendrogenin A: A mammalian metabolite of cholesterol with tumor suppressor and neurostimulating properties. Curr. Med. Chem., 22: 3533-3549.
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9:   Darblade, B., D. Caillaud, M. Poirot, M. Fouque and J.C. Thiers et al., 2001. Alteration of plasmalemmal caveolae mimics endothelial dysfunction observed in atheromatous rabbit aorta. Cardiovasc. Res., 50: 566-576.
PubMed  |  Direct Link  |  
10:   De Medina, P., B. Payre, N. Boubekeur, J. Bertrand-Michel and F. Terce, S. Silvente-Poirot and M. Poirot, 2009. Ligands of the antiestrogen-binding site induce active cell death and autophagy in human breast cancer cells through the modulation of cholesterol metabolism. Cell Death Differ., 16: 1372-1384.
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11:   De Medina, P., B.L. Payre, J. Bernad, I. Bosser and B. Pipy et al., 2004. Tamoxifen is a potent inhibitor of cholesterol esterification and prevents the formation of foam cells. J. Pharmacol. Exp. Ther., 308: 1165-1173.
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12:   De Medina, P., G. Favre and M. Poirot, 2004. Multiple targeting by the antitumor drug tamoxifen: a structure-activity study. Curr. Med. Chem. Anticancer Agents, 4: 491-508.
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13:   De Medina, P., M. Paillasse, B. Payre, S. Silvente-Poirot and M. Poirot, 2009. Synthesis of new alkylaminooxysterols with potent cell differentiating activities: Identification of leads for the treatment of cancer and neurodegenerative diseases. J. Med. Chem., 52: 7765-7777.
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14:   De Medina, P., M. Paillasse, G. Segala, M. Voisin and L. Mhamdi et al., 2013. Discovery of Dendrogenin A: A new cholesterol metabolite that triggers antitumor activities. Nat. Commun., Vol., 4 .
15:   De Medina, P., M.R. Paillasse, G. Segala, F. Khallouki and S. Brillouet et al., 2011. Importance of cholesterol and oxysterols metabolism in the pharmacology of tamoxifen and other AEBS ligands. Chem. Phys. Lipids, 164: 432-437.
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16:   De Medina, P., M.R. Paillasse, G. Segala, T. al Saati and J. Boyes et al., 2012. Technical note: Hapten synthesis, antibody production and development of an enzyme-linked immunosorbent assay for detection of the natural steroidal alkaloid Dendrogenin A. Biochimie, 95: 482-488.
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17:   De Medina, P., M.R. Paillasse, S. Segala, M. Poirot and S. Silvente-Poirot, 2010. Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands. Proc. Natl. Acad. Sci. USA., 107: 13520-13525.
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18:   De Medina, P., N. Boubekeur, P. Balaguer, G. Favre, S. Silvente-Poirot and M. Poirot, 2006. The prototypical inhibitor of cholesterol esterification, Sah 58-035 [3-[decyldimethylsilyl]-N-[2-(4-methylphenyl)-1-phenylethyl]propanamide], is an agonist of estrogen receptors. J. Pharmacol. Exp. Ther., 319: 139-149.
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19:   De Medina, P., R. Casper, J.F. Savouret and M. Poirot, 2005. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J. Med. Chem., 48: 287-291.
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20:   De Medina, P., S. Genovese, M.R. Paillasse, M. Mazaheri and S. Caze-Subra et al., 2010. Auraptene is an inhibitor of cholesterol esterification and a modulator of estrogen receptors. Mol. Pharmacol., 78: 827-836.
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21:   De Medina, P., S. Silvente-Poirot and M. Poirot, 2009. Tamoxifen and AEBS ligands induced apoptosis and autophagy in breast cancer cells through the stimulation of sterol accumulation. Autophagy, 5: 1066-1067.
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22:   Delarue, F., B. Kedjouar, F. Mesange, F. Bayard, J.C. Faye and M. Poirot, 1999. Modifications of benzylphenoxy ethanamine antiestrogen molecules: Influence affinity for antiestrogen binding site (AEBS) and cell cytotoxicity. Biochem. Pharmacol., 57: 657-661.
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23:   Doisneau-Sixou, S.F., P. Cestac, S. Chouini, J.S. Carroll and A.D. Hamilton et al., 2003. Contrasting effects of prenyltransferase inhibitors on estrogen-dependent cell cycle progression and estrogen receptor-mediated transcriptional activity in MCF-7 cells. Endocrinology, 144: 989-998.
PubMed  |  Direct Link  |  
24:   Dorbes, S., B. Mestre-Voegtle, Y. Coulais, C. Picard, S. Silvente-Poirot, M. Poirot and E. Benoist, 2010. Synthesis, characterization and In vitro evaluation of new oxorhenium- and oxotechnetium-CCK4 derivatives as molecular imaging agents for CCK2-receptor targeting. Eur. J. Med. Chem., 45: 423-429.
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25:   Fargin, A., F. Bayard, J.C. Faye, M. Traore, M. Poirot, A. Klaebe and J.J. Perie, 1988. Further evidence for a biological role of anti-estrogen-binding sites in mediating the growth inhibitory action of diphenylmethane derivatives. Chem. Biol. Interact, 66: 101-109.
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26:   Fransson, A., P. de Medina, M.R. Paillasse, S. Silvente-Poirot, M. Poirot and M. Ulfendahl, 2015. Dendrogenin A and B two new steroidal alkaloids increasing neural responsiveness in the deafened guinea pig. Front. Aging Neurosci., Vol. 7. .
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27:   Gales, C., D. Sanchez, M. Poirot, S. Pyronnet and L. Buscail et al., 2003. High tumorigenic potential of a constitutively active mutant of the cholecystokinin 2 receptor. Oncogene, 22: 6081-6089.
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28:   Gales, C., M. Poirot, J. Taillefer, B. Maigret and J. Martinez et al., 2003. Identification of tyrosine 189 and asparagine 358 of the cholecystokinin 2 receptor in direct interaction with the crucial C-terminal amide of cholecystokinin by molecular modeling, site-directed mutagenesis and structure/affinity studies. Mol. Pharmacol., 63: 973-982.
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29:   Garnier, M., C. Giamarchi, I. Delrieu, M.C. Rio and P. Chinestra et al., 2003. Insulin and estrogen receptor ligand influence the FGF-2 activities in MCF-7 breast cancer cells. Biochem. Pharmacol., 65: 629-636.
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30:   Garnier, M., M. Poirot, F. Bayard and J.C. Faye, 1991. A Mr 45,000 secreted protein is specifically induced by tamoxifen: Identification in the human breast cancer cell line, MCF-7, adapted to grow in chemically defined medium. J. Cell. Pharmacol., 2: 83-91.
31:   Guyot, E., X. Coumoul, J.F. Chasse, F. Khallouki, J.F. Savouret, M. Poirot, R. Barouki, 2012. Identification of a new stilbene-derived inducer of paraoxonase 1 and ligand of the Aryl hydrocarbon Receptor. Biochem. Pharmacol., 83: 627-632.
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32:   Iuliano, L., P.J. Crick, C. Zerbinati, L. Tritapepe and J. Abdel-Khalik et al., 2015. Cholesterol metabolites exported from human brain. Steroids, 99: 189-193.
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33:   Jordan, V.C., 2011. Four decades of discovery in breast cancer research and treatment--an interview with V. Craig Jordan. Interview by Marc Poirot. Int. J. Dev. Biol., 55: 703-712.
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34:   Kedjouar, B., P. De Medina, M. Oulad-Abdelghani, B. Payre and S. Silvente-Poirot et al., 2004. Molecular characterization of the microsomal tamoxifen binding site. J. Biol. Chem., 279: 34048-34061.
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35:   Kedjouar, B., S. Daunes, B.J. Vilner, W.D. Bowen, A. Klaebe, J.C. Faye and M. Poirot, 1999. Structural similitudes between cytotoxic antiestrogen-binding site (AEBS) ligands and cytotoxic sigma receptor ligands. Evidence for a relationship between cytotoxicity and affinity for AEBS or sigma-2 receptor but not for sigma-1 receptor. Biochem. Pharmacol., 58: 1927-1939.
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36:   Khalifa, S.A.M., P. de Medina, A. Erlandsson, H.R. El Seedi, S. Silvente-Poirot and M. Poirot, 2014. The novel steroidal alkaloids dendrogenin A and B promote proliferation of adult neural stem cells. Biochem. Biophys. Res. Commun., 446: 681-686.
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37:   Khallouki, F., P. de Medina, S. Caze-Subra, K. Bystricky, P. Balaguer, M. Poirot and S. Silvente-Poirot, 2016. Molecular and biochemical analysis of the estrogenic and proliferative properties of vitamin e compounds. Frontiers Oncol., Vol. 5. .
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38:   Klionsky, D.J., F.C. Abdalla, H. Abeliovich, R.T. Abraham and A. Acevedo-Arozena et al., 2012. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8: 445-544.
PubMed  |  Direct Link  |  
39:   Klionsky, D.J., K. Abdelmohsen, A. Abe, M.J. Abedin and H. Abeliovich et al., 2016. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 12: 1-222.
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40:   Mauxion, T., J. Barbet, J. Suhard , J.P. Pouget, M. Poirot and M. Bardies, 2013. Improved realism of hybrid mouse models may not be sufficient to generate reference dosimetric data. Med. Phys., Vol., 40. 10.1118/1.4800801.
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41:   Mesange, F., M. Sebbar, B. Kedjouar, J. Capdevielle and J.C. Guillemot et al., 1998. Microsomal epoxide hydrolase of rat liver is a subunit of theanti-oestrogen-binding site. Biochem. J., 334: 107-112.
PubMed  |  Direct Link  |  
42:   Mesange, F., M. Sebbar, J. Capdevielle, J.C. Guillemot, P. Ferrara, F. Bayard, M. Poirot and J.C. Faye, 2002. Identification of two tamoxifen target proteins by photolabeling with 4-(2-morpholinoethoxy)benzophenone. Bioconjug. Chem., 13: 766-772.
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43:   Paillas, S., A. Causse, P. de Medina, M. Poirot and V. Denis et al., 2012. MAPK14 p38alpha confers Irinotecan resistance to tp53-defective cells by inducing survival autophagy. Autophagy, 8: 1098-1112.
44:   Paillasse, M.R., C. Deraeve, P. de Medina, L. Mhamdi, G. Favre, M. Poirot and S. Silvente-Poirot, 2006. Insights into the cholecystokinin 2 receptor binding site and processes of activation. Mol. Pharmacol., 70: 1935-1945.
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45:   Paillasse, M.R., N. Saffon, H. Gornitzka, S. Silvente-Poirot, M. Poirot and P. de Medina, 2012. Surprising unreactivity of cholesterol-5,6-epoxides towards nucleophiles. J. Lipid Res., 53: 718-725.
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46:   Paillasse, M.R., P. de Medina, G. Amouroux, L. Mhamdi, M. Poirot and S. Silvente-Poirot, 2009. Signaling through cholesterol esterification: A new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion. J. Lipid Res., 50: 2203-2211.
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47:   Payre, B., P. de Medina, N. Boubekeur, L. Mhamdi and J. Bertrand-Michel et al., 2008. Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism. Mol. Cancer Ther., 7: 3707-3717.
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48:   Plisov, S.Y., M.E. Poirot, K.J. Modarress, A.H. Cavanaugh, D.P. Edwards and S.S. Simons Jr., 1998. Different populations of progesterone receptor-steroid complexes in binding to specific DNA sequences: Effects of salts on kinetics and specificity. J. Steroid Biochem. Mol. Biol., 67: 251-266.
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49:   Poirot, M. and S. Silvente-Poirot, 2012. Cholesterol-5,6-epoxides: Chemistry, biochemistry, metabolic fate and cancer. Biochimie, 95: 622-631.
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50:   Poirot, M. and S. Silvente-Poirot, 2013. Oxysterols and related sterols: Implication in physiopathology and pharmacology. Biochem. Pharmacol., 86: 1-2.
51:   Poirot, M., C. Chailleux, A. Fargin, F. Bayard and J.C. Faye, 1990. A potent and selective photoaffinity probe for the anti-estrogen binding site of rat liver. J. Biol. Chem., 265: 17039-17043.
PubMed  |  Direct Link  |  
52:   Poirot, M., C. Chailleux, F. Bayard and J.C. Faye, 1992. Cytosolic type II estrogen binding site in rat uterus: Specific photolabeling with estrone. J. Recept. Res., 12: 217-231.
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53:   Poirot, M., C. Chailleux, F. Mesange, F. Bayard and J.C. Faye, 1994. Characterization of the membranous antiestrogen binding protein: II Purification to homogeneity. J. Recept. Res., 14: 37-46.
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54:   Poirot, M., M. Garnier, F. Bayard, I. Riviere and M. Traore et al., 1990. The anti-proliferative properties of 4-benzylphenoxy ethanamine derivatives are mediated by the anti-estrogen binding site (ABS), whereas the anti-estrogenic effects of trifluopromazine are not. Biochem. Pharmacol., 40: 425-429.
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55:   Poirot, M., P. De Medina, F. Delarue, J.J. Perie, A. Klaebe and J.C. Faye, 2000. Synthesis, binding and structure-affinity studies of new ligands for the microsomal anti-estrogen binding site (AEBS). Bioorg. Med. Chem., 8: 2007-2016.
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56:   Poirot, M., S. Silvente-Poirot and R.R. Weichselbaum, 2012. Cholesterol metabolism and resistance to tamoxifen in breast cancers. Curr. Opin. Pharmacol., 12: 683-689.
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57:   Record, M., C. Subra, S. Silvente-Poirot and M. Poirot, 2011. Exosomes as intercellular signalosomes and pharmacological effectors. Biochem. Pharmacol., 81: 1171-1182.
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58:   Record, M., K. Carayon, M. Poirot and S. Silvente-Poirot, 2014. Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies. Biochimica Biophysica Acta (BBA)-Mol. Cell Biol. Lipids, 1841: 108-120.
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59:   Record, M., M. Poirot and S. Silvente-Poirot, 2014. Emerging concepts on the role of exosomes in lipid metabolic diseases. Biochimie, 96: 67-74.
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60:   Savouret, J.F., R. Casper and M. Poirot, 2006. Resveratrol and its derivatives: A new family of antagonists of the aryl hydrocarbon receptor. Actualitu. Chimiqu., 303: 34-36.
61:   Segala, G., P. de Medina, L. Iuliano, C. Zerbinati and M.R. Paillasse et al., 2013. 5,6-Epoxy-cholesterols contribute to the anticancer pharmacology of Tamoxifen in breast cancer cells. Biochem. Pharmacol., 86: 175-189.
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62:   Silvente-Poirot, S. and M. Poirot, 2012. Cholesterol epoxide hydrolase and cancer. Curr. Opin. Pharmacol., 12: 696-703.
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63:   Silvente-Poirot, S. and M. Poirot, 2012. Cholesterol metabolism and cancer: The good, the bad and the ugly. Curr. Opin. Pharmacol., 12: 673-676.
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64:   Silvente-Poirot, S. and M. Poirot, 2014. Cholesterol and cancer in the balance. Science, 343: 1445-1446.
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65:   Sola, B., M. Poirot, P. de Medina, S. Bustany, V. Marsaud, S. Silvente-Poirot and J.M. Renoir, 2013. Antiestrogen-binding site ligands induce autophagy in myeloma cells that proceeds through alteration of cholesterol metabolism. Oncotarget, 4: 911-922.
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66:   Subra, C., D. Grand, K. Laulagnier, A. Stella and G. Lambeau et al., 2010. Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins. J. Lipid Res., 51: 2105-2120.
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67:   Tosolini, M., F. Pont, D. Betous, E. Ravet and L. Ligat et al., 2015. Human monocyte recognition of adenosine-based cyclic di-nucleotides unveils the A2a GPCR tonic inhibition of mitochondrial-induced cell death. Mol. Cell Biol., 35: 479-495.
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68:   Voisin, M., S. Silvente-Poirot and M. Poirot, 2014. One step synthesis of 6-oxo-cholestan-3β, 5α-diol. Biochem. Biophys. Res. Commun., 446: 782-785.
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