Dr. Lorenzo Jose Fraile Sauce

Dr. Lorenzo Jose Fraile Sauce

Research Scientist
Universitat de Lleida, Spain


Highest Degree
Ph.D. in Veterinary Sciences from Universidad de Zaragoza, Spain

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Biography

Dr. Lorenzo Jose Fraile Sauce is currently working as Lecturer at University of Lleida Spain. He has completed his Ph.D. in Veterinary Sciences from Universidad de Zayragoza, Spain. His main area of interest focuses on Pharmacology and Toxicology and Animal and Veterinary Sciences. His area of expertise includes Epidemiology, Veterinary science, Pharmacology, Pharmacokineticsl, PK/PD models, Infectious Diseases, Vaccinology, Immune response, Antimicrobials, Treatment, Pig Medicine, Pig production, Animal Science Immunology, Vaccine, and Animal production. He has published b79 research articles in journals contributed as author/co-author.

Area of Interest:

Biomedical Sciences
100%
Immunology
62%
Veterinary Microbiology
90%
Vaccine
75%
Immunopathology
55%

Selected Publications

  1. Munoz-Gonzaez, S., N. Ruggli, R. Rosell, L. Josue Perez, and M.T. Frias-Leuporea et al., 2015. Postnatal persistent infection with classical swine fever virus and its immunological implications. PLoS One, 10: 1-22.
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  2. Martinez-Orellana, P., J. Martorell, B. Vidana , N. Majo, A. Falcon et al., 2015. Clinical response to pandemic H1N1 influenza virus from a fatal and mild case in ferrets. Virol.J., 12: 48-57.
    CrossRef  |  

  3. Fraile, L., Y. Saco. L. Grau-Roma, M. Nofrarias and S. Lopez-Soria et al., 2015. Serum haptoglobin dynamics in pigs vaccinated or not vaccinated against porcine circovirus type 2. Porcine Health Manag., Vol.1. 10.1186/2055-5660-1-3.
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  4. Fraile, L., J. Segales, G. Tico, S. Lopez-Soria and O. Valero et al., 2015. Virological and serological characterization of vaccinated and non-vaccinated piglet subpopulations coming from vaccinated and non-vaccinated sows. Prev. Vet. Med., 119: 153-161.
    CrossRef  |  PubMed  |  Direct Link  |  

  5. Dieste-Perez, L., L. Fraile, M.J. de Miguel, M. Barberan, J.M. Blasco and M. Munoz, 2015. Studies on a suitable antibiotic therapy for treating swine brucellosis. J. Vet. Pharmacol. Ther., 38: 357-364.
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  6. Crisci, E., L. Fraile, R. Novellas, Y. Espada and R. Cabezon et al., 2015. In vivo tracking and immunological properties of pulsed porcine monocyte-derived dendritic cells. Mol. Immunol., 63: 343-354.
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  7. Crisci, E., L. Fraile, R. Novellas, Y. Espada and R. Cabezon et al., 2015. In vivo tracking and immunological properties of pulsed porcine monocyte-derived dendritic cells. Mol. Immunol., 63: 343-354.
    CrossRef  |  PubMed  |  Direct Link  |  

  8. Cano, G., M. Hows, R. Janes, A. Morillo and L. Fraile , 2015. Dose dependent penetration of tulathromycin in pig tonsils. Pharmacologia, 6: 110-113.
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  9. Cameron-Veas, K., M. Sola-Gines, M.A. Moreno, L. Fraile and L. Migura-Garcia, 2015. Impact of the use of β-lactam antimicrobials on the emergence of Escherichia coli isolates resistant to cephalosporins under standard pig-rearing conditions. Appl. Environ. Microbiol., 81: 1782-1787.
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  10. Cameron-Veas K., M. Sola-Gines, M.A. Moreno, L. Fraile and L. Migura, 2015. Impact of the use of beta-lactam antimicrobials on the emergence of Escherichia coli resistant to cephalosporins under standard pig rearing conditions. Appl.Environ. Microbiol., 81: 1782-1787.
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  11. Armengol, R. and L. Fraile, 2015. Comparison of two treatment strategies for cows with metritis in high-risk lactating dairy cows. Theriogenology, 83: 1344-1351.
    CrossRef  |  PubMed  |  Direct Link  |  

  12. Vilalta, C., H. Giboin, M. Schneider, F. El Garch and L. Fraile, 2014. Pharmacokinetic/pharmacodynamic evaluation of marbofloxacin in the treatment of Haemophilus parasuis and Actinobacillus pleuropneumoniae infections in nursery and fattener pigs using Monte Carlo simulations. J. Vet. Pharmacol. Ther., 37: 542-549.
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  13. Tarradas, J., M.E. de la Torre, R. Rosell, L.J. Perez and J. Pujols et al., 2014. The impact of CSFV on the immune response to control infection. Virus Res., 185: 82-91.
    CrossRef  |  PubMed  |  Direct Link  |  

  14. Sibila, M., V. Aragon, L. Fraile and J. Segales, 2014. Comparison of four lung scoring systems for the assessment of the pathological outcomes derived from Actinobacillus pleuropneumoniae experimental infections. BMC Vet. Res., 10: 165-165.
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  15. Sibila, M., V. Aragon, L. Fraile and J. Segales, 2014. Comparison of four lung scoring systems for the assessment of the pathological outcomes derived from Actinobacillus pleuropneumoniae experimental infections. BMC Vet. Res., 10: 165-165.
    CrossRef  |  PubMed  |  Direct Link  |  

  16. Pileri, E., M. Cortey, F. Rodriguez, M. Sibila, L. Fraile and J. Segales, 2014. Comparison of the immunoperoxidase monolayer assay and three commercial ELISAs for detection of antibodies against porcine circovirus type 2. Vet. J., 201: 429-432.
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  17. Pileri, E., M. Cortey, F. Rodriguez, M. Sibila, L. Fraile and J. Segales, 2014. Comparison of the immunoperoxidase monolayer assay and three commercial ELISAs for detection of antibodies against porcine circovirus type 2. Vet. J., 201: 429-432.
    CrossRef  |  PubMed  |  Direct Link  |  

  18. Garcia-Migura, L., R.S. Hendriksen, L. Fraile and F.M. Aarestrup, 2014. Antimicrobial resistance of zoonotic and commensal bacteria in Europe: The missing link between consumption and resistance in veterinary medicine. Vet. Microbiol., 170: 1-9.
    CrossRef  |  PubMed  |  Direct Link  |  

  19. Garcia-Migura, L., R.S. Hendriksen, L. Fraile and F.M. Aarestrup, 2014. Antimicrobial resistance of zoonotic and commensal bacteria in Europe: The missing link between consumption and resistance in veterinary medicine. Vet. Microbiol., 170: 1-9.
    CrossRef  |  PubMed  |  Direct Link  |  

  20. Dieste-Perez, L., L. Fraile, M.J. de Miguel, M. Barberan, J.M. Blasco and M. Munoz, 2014. Studies on a suitable antibiotic therapy for treating swine brucellosis. J. Vet. Pharmacol. Ther. 10.1111/jvp.12189.
    CrossRef  |  PubMed  |  Direct Link  |  

  21. Crisci, E., L. Fraile, S. Valentino, L. Martinez-Guino, B. Bottazzi, A. Mantovani and M. Montoya, 2014. Immune characterization of long pentraxin in pigs. Vet. Microbiol., 168: 185-192.
    CrossRef  |  Direct Link  |  

  22. Baratelli, M., L. Cordoba, L.J. Perez, J. Maldonado, L. Fraile, J.I. Nunez and M. Montoya, 2014. Genetic characterization of influenza A viruses circulating in pigs and isolated in north-east Spain during the period 2006-2007 Res. Vet. Sci., 96: 380-388.
    CrossRef  |  Direct Link  |  

  23. Sibila, M., L. Fraile, G. Tico, S. Lopez-Soria and M. Nofrarias et al., 2013. Humoral response and colostral antibody transfer following one-dose pre-mating vaccination of sows against porcine circovirus type-2. Vet. J., 197: 881-883.
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  24. Mussa, T., M. Ballester, E. Silva-Campa, M. Baratelli and N. Busquets et al., 2013. Infection by swine, human or avian influenza viruses differentially activates porcine dendritic cells cytokine profile. Vet. Immunol. Immunopathol., 154: 25-35.
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  25. Crisci, E., T. Mussa, L. Fraile and M. Montoya, 2013. Review: Influenza virus in pigs. Mol. Immunol., 55: 200-211.
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  26. Crisci, E., L. Fraile, S. Valentino, L. Martinez-Guino, B. Bottazzi, A. Mantovani and M. Montoya, 2013. Immune characterization of long pentraxin 3 in pigs infected with influenza virus. Vet. Microbiol., 10.1016/j.vetmic.2013.10.004.
    CrossRef  |  

  27. Crisci, E., T. Mussa, L. Fraile and M. Montoya, 2013. Review on influenza virus in pigs. Mol. Immunol., 55: 200-211.
    CrossRef  |  Direct Link  |  

  28. Baratelli, M., L. Cordoba, L.J. Perez, J. Maldonado, L. Fraile, J.I. Nunez and M. Montoya, 2013. Genetic characterization of influenza A viruses circulating in pigs and isolated in north-east Spain during the period 2006-2007. Res. Vet. Sci., 10.1016/j.rvsc.2013.12.006.
    CrossRef  |  

  29. Vilalta,C., T. Alcala, R. Lopez-Jimenez, M. Nofrarias and S. Lopez-Soria et al., 2012. Clinical efficacy of acetyl salicylic acid as an adjunct to the antibacterial treatment of porcine respiratory disease complex. J. Swine Health Prod., 20: 10-16.

  30. Vilalta, C., N. Galofre, V. Aragon, A.M. Perez de Rozas and L. Fraile, 2012. Effect of marbofloxacin on Haemophilus parasuis nasal carriage. Vet. Microbiol., 159: 123-129.
    CrossRef  |  

  31. Tarradas, J., M. Monso, L. Fraile, B.G. de la Torre and M. Munoz et al., 2012. A T-cell epitope on NS3 non-structural protein enhances the B and T cell responses elicited by dendrimeric constructions against CSFV in domestic pigs. Vet. Immunol. Immunopathol., 150: 36-46.
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  32. Nieto, D., M. Aramouni, M. Sibila, L. Fraile, T. Kekarainen and J. Segales, 2012. Lack of effect of piglet vaccination against Porcine circovirus type 2 (PCV2) on serum viral loads of Torque teno sus virus 2 (TTSuV2). Vet. Microbiol., 157: 8-12.
    CrossRef  |  PubMed  |  

  33. Mussa, T., C. Rodriguez-Carino, A. Sanchez-Chardi, M. Baratelli and M. Costa-Hurtado et al., 2012. Differential interactions of virulent and non-virulent H. parasuis strains with naive or swine influenza virus pre-infected dendritic cells. Vet. Res., Vol. 43. 10.1186/1297-9716-43-80.
    CrossRef  |  

  34. Grau-Roma, L., P. Baekbo, N. Rose, P. Wallgren, L. Fraile, L.E. Larsen and J. Segales, 2012. Clinical and laboratorial studies on postweaning multisystemic wasting syndrome (PMWS) affected herds in Denmark, France, Spain and Sweden: Disease progression and a proposal of herd case definition. J. Swine Health Prod., 20: 129-136.
    Direct Link  |  

  35. Grau-Roma, L., A. Stockmarr, C.S. Kristensen, C. Enoe and S. Lopez-Soria et al., 2012. Infectious risk factors for individual postweaning multisystemic wasting syndrome (PMWS) development in pigs from affected farms in Spain and Denmark. Res. Vet. Sci., 93: 1231-1240.
    CrossRef  |  

  36. Fraile, L., M. Sibila, M. Nofrarias, R. Lopez-Jimenez and E. Huerta et al., 2012. Effect of sow and piglet porcine circovirus type 2 (PCV2) vaccination on piglet mortality, viremia, antibody titer and production parameters. Vet. Microbiol., 161: 229-234.
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  37. Fraile, L., L. Grau-Roma, P. Sarasola, N. Sinovas and M. Nofrarias et al., 2012. Inactivated PCV2 one shot vaccine applied in 3-week-old piglets: Improvement of production parameters and interaction with maternally derived immunity. Vaccine, 30: 1986-1992.
    CrossRef  |  

  38. Fraile, L., E. Crisci, L. Cordoba, M.A. Navarro, J. Osada and M. Montoya, 2012. Immunomodulatory properties of Beta-sitosterol in pig immune responses. Int. Immunopharmacol., 13: 316-321.
    CrossRef  |  

  39. Fraile, L., 2012. Control or eradication? Costs and benefits in the case of PRRSV. Vet. Rec., 170: 223-224.
    CrossRef  |  

  40. Crisci, E., L. Fraile, N. Moreno, E. Blanco and R. Cabezon et al., 2012. Chimeric calicivirus-like particles elicit specific immune responses in pigs. Vaccine, 30: 2427-2439.
    CrossRef  |  

  41. Vilalta, C., M. Schneider, R. Lopez-Jimenez, J.M. Caballero, M. Gottschalk and L. Fraile, 2011. Marbofloxacin reaches high concentration in pig tonsils in a dose-dependent fashion. J. Vet. Pharmacol. Ther., 34: 95-97.
    CrossRef  |  

  42. Tarradas, J., M. Monso, M. Munoz, R. Rosell and L. Fraile et al., 2011. Partial protection against classical swine fever virus elicited by dendrimeric vaccine-candidate peptides in domestic pigs. Vaccine, 29: 4422-4429.
    CrossRef  |  

  43. Tarradas, J., B. Alvarez, L. Fraile, R. Rosell and M. Munoz et al., 2011. Immunomodulatory effect of swine CCL20 chemokine in DNA vaccination against CSFV. Vet. Immunol. Immunopathol., 142: 243-251.
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  44. Saco, Y., L. Fraile, M. Gimenez, A. Alegre and R. Lopez-Jimenez et al., 2011. Serum acute phase proteins as biomarkers of pleuritis and cranio-ventral pulmonary consolidation in slaughter-aged pigs. Res. Vet. Sci., 91: 52-57.
    CrossRef  |  

  45. Mussa, T., C. Rodriguez-Carino, M. Pujol, L. Cordoba and N. Busquets et al., 2011. Interaction of porcine conventional dendritic cells with swine influenza virus. Virology, 420: 125-134.
    CrossRef  |  

  46. Grau-Roma, L., L. Fraile and J. Segales, 2011. Recent advances in the epidemiology, diagnosis and control of diseases caused by porcine circovirus type 2. Vet. J., 187: 23-32.
    CrossRef  |  

  47. Silva-Campa, E., L. Cordoba, L. Fraile, L. Flores-Mendoza, M. Montoya and J. Hernandez, 2010. European genotype of porcine reproductive and respiratory syndrome (PRRSV) infects monocyte-derived dendritic cells but does not induce Treg cells. Virology, 396: 264-271.
    CrossRef  |  

  48. Saco, Y., L. Fraile, M. Gimenez, R. Pato, M. Montoya and A. Bassols, 2010. Haptoglobin serum concentration is a suitable biomarker to assess the efficacy of a feed additive in pigs. Animal, 4: 1561-1567.
    CrossRef  |  PubMed  |  

  49. Saco, Y., L. Fraile, M. Gimenez, F. Canalias and A. Bassols, 2010. Validation of an immunoturbidimetric method for determination of porcine serum C-reactive protein. Res. Vet. Sci., 89: 159-162.
    CrossRef  |  

  50. Fraile, L., A. Alegre, R. Lopez-Jimenez, M. Nofrarias and J. Segales, 2010. Risk factors associated with pleuritis and cranio-ventral pulmonary consolidation in slaughter-aged pigs. Vet. J., 184: 326-333.
    CrossRef  |  

  51. Busquets, N., J. Segales, L. Cordoba, T. Mussa and E. Crisci et al., 2010. Experimental infection with H1N1 European swine influenza virus protects pigs from an infection with the 2009 pandemic H1N1 human influenza virus. Vet. Res., Vol. 41. 10.1051/vetres/2010046.
    CrossRef  |  PubMed  |  

  52. Aragon, V., M. Cerda-Cuellar, L. Fraile, M. Mombarg and M. Nofrarias et al., 2010. Correlation between clinico-pathological outcome and typing of Haemophilus parasuis field strains. Vet. Microbiol., 142: 387-393.
    CrossRef  |  

  53. Segales, J., A. Urniza, A. Alegre, T. Bru and E. Crisci et al., 2009. A genetically engineered chimeric vaccine against porcine circovirus type 2 (PCV2) improves clinical, pathological and virological outcomes in postweaning multisystemic wasting syndrome affected farms. Vaccine, 27: 7313-7321.
    CrossRef  |  

  54. Grau-Roma, L., P.M. Heegaard, C.K. Hjulsager, M. Sibila and C.S. Kristensen et al., 2009. Pig-major acute phase protein and haptoglobin serum concentrations correlate with PCV2 viremia and the clinical course of postweaning multisystemic wasting syndrome. Vet. Microbiol., 138: 53-61.
    CrossRef  |  

  55. Grau-Roma, L., C.K. Hjulsager, M. Sibila, C.S. Kristensen and S. Lopez-Soria et al., 2009. Infection, excretion and seroconversion dynamics of porcine circovirus type 2 (PCV2) in pigs from post-weaning multisystemic wasting syndrome (PMWS) affected farms in Spain and Denmark. Vet. Microbiol., 135: 272-282.
    CrossRef  |  

  56. Fraile, L.J., E. Crisci, J. Weenberg, M. Armadans and L. Mendoza et al., 2009. Effect of treatment with phytosterols in three herds with porcine respiratory disease complex. J. Swine Health Prod., 17: 32-41.

  57. Fraile, L., M. Calsamiglia, E. Mateu, A. Espinal and A. Cuxart et al., 2009. Prevalence of infection with porcine circovirus-2 (PCV-2) and porcine reproductive and respiratory syndrome virus (PRRSV) in an integrated swine production system experiencing postweaning multisystemic wasting syndrome. Can. J. Vet. Res., 73: 308-312.
    Direct Link  |  

  58. Crisci, E., H. Almanza, I. Mena, L. Cordoba and E. Gomez-Casado et al., 2009. Chimeric calicivirus-like particles elicit protective anti-viral cytotoxic responses without adjuvant. Virology, 387: 303-312.
    CrossRef  |  

  59. Grau-Roma, L., E. Crisci, M. Sibila, S. Lopez-Soria and M. Nofrarias et al., 2008. A proposal on porcine circovirus type 2 (PCV2) genotype definition and their relation with postweaning multisystemic wasting syndrome (PMWS) occurrence. Vet. Microbiol., 128: 23-35.
    CrossRef  |  

  60. Calsamiglia, M., L. Fraile, A. Espinal, A. Cuxart and C. Seminati et al., 2007. Sow porcine circovirus type 2 (PCV2) status effect on litter mortality in postweaning multisystemic wasting syndrome (PMWS). Res. Vet. Sci., 82: 299-304.
    CrossRef  |  

  61. Rueda, S., L.J. Fraile, M.A. Bregante, M.A. Garcia and C. Solans, 2002. Penetration of diltiazem into breast milk and its pharmacokinetics in the lactating rabbit. Xenobiotica, 32: 119-130.
    CrossRef  |  

  62. Fraile, L.J., M.A. Bregante, M.A. Garcia and C. Solans, 2001. Development of diltiazem deacetylase and demethylase activities during ontogeny in rabbit. Xenobiotica, 31: 409-422.
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  63. Fraile, L.J., M.A. Bregante, M.A. Garcia and C. Solans, 2001. Altered diltiazem metabolism in the neonatal rabbit following intra-uterine chronic exposure to diltiazem. Xenobiotica, 31: 177-185.
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  64. Solans, C., M.A. Bregante, J.J. Aramayona, L.J. Fraile and M.A. Garcia, 2000. Pharmacokinetics of verapamil in New Zealand white rabbits during ontogeny. Neonatology, 78: 321-326.
    CrossRef  |  

  65. Solans, C., M.A. Bregante, J.J. Aramayona, L.J. Fraile and M.A. Garcia, 2000. Comparison of the pharmacokinetics of verapamil in the pregnant and non-pregnant rabbit: Study of maternal and foetal tissue levels. Xenobiotica, 30: 93-102.
    CrossRef  |  Direct Link  |  

  66. Solans, C., J.J. Aramayona, M.A. Bregante, L.J. Fraile, S. Rueda and M.A. Garcia, 2000. Pharmacokinetics of verapamil in lactating rabbits: Prediction of verapamil distribution into rabbit milk. Gen. Pharmacol.: Vasc. Syst., 34: 237-243.
    CrossRef  |  

  67. Bregante, M.A., J.J. Aramayona, L.J. Fraile, M.A. Garcia and C. Solans, 2000. Diltiazem blood pharmacokinetics in the pregnant and non-pregnant rabbit: Maternal and foetal tissue levels. Xenobiotica, 30: 831-841.
    Direct Link  |  

  68. Bregante, M.A., P. Saez, J.J. Aramayona, L. Fraile, M.A. Garcia and C. Solans, 1999. Comparative pharmacokinetics of enrofloxacin in mice, rats, rabbits, sheep and cows. Am. J. Vet. Res., 60: 1111-1116.
    PubMed  |  

  69. Garcia, M.A., C. Solans, J.J. Aramayona, L.J. Fraile, M.A. Bregante and J.R. Castillo, 1998. A common method for the determination of several calcium channel blockers using an HPLC system with ultraviolet detection. Talanta, 47: 1245-1254.
    PubMed  |  

  70. Garcia, M.A., J.J. Aramayona, M.A. Bregante, L.J. Fraile and C. Solans, 1997. Simultaneous determination of verapamil and norverapamil in biological samples by high-performance liquid chromatography using ultraviolet detection. J. Chromatogr. B: Biomed. Sci. Applic., 693: 377-382.
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  71. Fraile, L.J., J.J. Aramayona, M.A. Bregante, M.A. Garcia and C. Solans, 1997. Enhanced diltiazem deacetylase activity in pre-term and full-term rabbits compared with adult rabbits. Neonatology, 72: 51-61.
    CrossRef  |  

  72. Fraile, L.J., C. Martinez, J.J. Aramayona, A.R. Abadia, M.A. Bregante and M.A. Garcia, 1997. Limited capacity of neonatal rabbits to eliminate enrofloxacin and ciprofloxacin. Vet. Q., 19: 162-167.
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  73. Aramayona, J.J., M.A. Bregante, C. Solans, S. Rueda, L.J. Fraile and M.A. Garcia, 1997. Pharmacokinetics of fosfomycin in chickens after a single intravenous dose and tissue levels following chronic oral administration. Vet. Res., 28: 581-588.
    PubMed  |  

  74. Fraile, L.J., J.J. Aramayona, M.A. Bregante, M.A. Garcia and A.R. Abadia, 1996. Deacetylation of diltiazem by several rabbit tissues. Pharm. Res., 13: 1875-1880.
    CrossRef  |  

  75. Aramayona, J.J., J. Mora, L.J. Fraile, M.A. Garcia, A.R. Abadia and M.A. Bregante, 1996. Penetration of enrofloxacin and ciprofloxacin into breast milk and pharmacokinetics of the drugs in lactating rabbits and neonatal offspring. Am. J. Vet. Res., 57: 547-553.
    PubMed  |  

  76. Aramayona, J.J., M.A. Garcia, L.J. Fraile, A.R. Abadia and M.A. Bregante, 1994. Placental transfer of enrofloxacin and ciprofloxacin in rabbits. Am. J. Vet. Res., 55: 1313-1315.
    PubMed  |