Dr. Maria de Fatima Moreira Martel

Dr. Maria de Fatima Moreira Martel

Associate Professor
University of Porto, Portugal


Highest Degree
Ph.D. in Human Biology from University of Porto, Portugal

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Area of Interest:

Biomedical Sciences
100%
Translational Medicine
62%
Epitelial Transport
90%
Organic Cations
75%
Catecholamines
55%

Education

2006

Ph.D.

University of Porto, Portugal

Human Biology

Selected Publications

  1. Moreira, L., I. Araujo, T. Costa, A. Correia-Branco, A. Faria, F. Martel and E. Keating, 2013. Quercetin and epigallocatechin gallate inhibit glucose uptake and metabolism by breast cancer cells by an estrogen Receptor-independent mechanism. Exp. Cell Res., 319: 1784-1795.
    CrossRef  |  

  2. Martins, M.J. and F. Martel, 2013. An innovative laboratory research practice supporting introduction to research methodology in the medical undergraduate curriculum: The students' perspective. J. Contemporary Med. Educ., 1: 3-8.
    CrossRef  |  

  3. Araujo, J.R., A. Correia-Branco, L. Moreira, C. Ramalho, F. Martel and E. Keating, 2013. Folic acid uptake by the human syncytiotrophoblast is affected by gestational diabetes, hyperleptinemia, and TNF-α. Pediatr. Res., 73: 388-894.
    CrossRef  |  PubMed  |  Direct Link  |  

  4. Lemos, C., A. Faria, M. Meireles, F. Martel, R. Monteiro and C. Calhau, 2012. Thiamine is a substrate of organic cation transporters in Caco-2 cells. Eur. J. Pharmacol., 682: 37-42.
    CrossRef  |  

  5. Goncalves, P., T. Catarino, I. Gregorio and F. Martel, 2012. Inhibition of butyrate uptake by the primary bile salt chenodeoxycholic acid in intestinal epithelial cells. J. Cell. Biochem., 113: 2937-2947.
    CrossRef  |  

  6. Goncalves, P., I. Gregorio, T.A. Catarino and F. Martel, 2012. The effect of oxidative stress upon the intestinal epithelial uptake of butyrate. Eur. J. Pharmacol., 699: 88-100.
    CrossRef  |  

  7. Goncalves, P., I. Gregorio, J.R. Araujo and F. Martel, 2012. The effect of clotrimazole on energy substrate uptake and carcinogenesis in intestinal epithelial cells. Anti-Cancer Drugs, 23: 220-229.

  8. Couto, M.R., P. Goncalves, T. Catarino, J.R. Araujo, A. Correia-Branco and F. Martel, 2012. The effect of oxidative stress upon the intestinal uptake of folic acid: In vitro studies with Caco-2 cells. Cell Biol. Toxicol., 28: 369-381.
    CrossRef  |  

  9. Goncalves, P., J.R. Araujo, M.J. Pinho and F. Martel, 2011. In vitro studies on the inhibition of colon cancer by butyrate and polyphenolic compounds. Nutr. Cancer, 63: 282-294.
    CrossRef  |  

  10. Goncalves, P., J.R. Araujo and F. Martel, 2011. Characterization of butyrate uptake by nontransformed intestinal epithelial cell lines. J. Membrane Biol., 240: 35-46.
    CrossRef  |  

  11. Goncalves, P., I. Gregorio and F. Martel, 2011. The Short-chain fatty acid butyrate is a substrate of breast cancer resistance protein. Am. J. Physiol.-Cell Physiol., 301: C984-C994.
    CrossRef  |  

  12. Tavares, S., J. Sousa, P. Goncalves, J.R. Araujo and F. Martel, 2010. The effect of folate status on the uptake of physiologically relevant compounds by Caco-2 cells. Eur. J. Pharmacol., 640: 29-37.

  13. Goncalves, P., J.R. Araujo and F. Martel, 2010. Effect of some natural mineral waters in nutrient uptake by Caco-2 cells. Int. J. Vitamin Nutr. Res., 80: 131-143.
    CrossRef  |  

  14. Faria, A., R. Monteiro, D. Pestana, F. Martel, V. de Freitas, N. Mateus and C. Calhau, 2010. Impact of high extracellular glucose levels on the intestinal uptake of organic cations. Cytotechnology, 62: 23-29.

  15. Araujo, J.R., P. Goncalves and F. Martel, 2010. Characterization of uptake of folates by rat and human blood-brain barrier endothelial cells. BioFactors, 36: 201-209.
    CrossRef  |  

  16. Keating, E., P. Goncalves, I. Campos, F. Costa and F. Martel, 2009. Folic acid uptake by the human syncytiotrophoblast: Interference by pharmacotherapy, drugs of abuse and pathological conditions. Reproductive Toxicol., 28: 511-520.
    CrossRef  |  

  17. Keating, E., P. Goncalves, F. Costa, I. Campos, M.J. Pinho, I. Azevedo and F. Martel, 2009. Comparison of the transport characteristics of bioactive substances in IUGR and normal placentas. Pediatric Res., 66: 495-500.
    CrossRef  |  

  18. Goncalves, P., J.R. Araujo, M.J. Pinho and F. Martel, 2009. Modulation of butyrate transport in Caco-2 cells. Naunyn-Schmiedeberg's Arch. Pharmacol., 379: 325-336.
    CrossRef  |  

  19. Faria, A., D. Pestana, J. Azevedo, F. Martel, V. de Freitas, I. Azevedo, N. Mateus and C. Calhau, 2009. Absorption of anthocyanins through intestinal epithelial cells-Putative involvement of GLUT2. Mol. Nutr. Food Res., 53: 1430-1437.
    CrossRef  |  

  20. Araujo, J.R., P. Goncalves and F. Martel, 2009. Effect of cannabinoids upon the uptake of folic acid by BeWo cells. Pharmacology, 83: 170-176.
    CrossRef  |  PubMed  |  Direct Link  |  

  21. Santos, A., P. Goncalves, J.R. Araujo and F. Martel, 2008. Intestinal permeability to glucose after experimental traumatic brain injury: Effect of gadopentetate dimeglumine administration. Basic Clin. Pharmacol. Toxicol., 103: 247-254.
    CrossRef  |  

  22. Mota, A., P. Silva, D. Neves, C. Lemos and C. Calhau et al., 2008. Characterization of rat heart alkaline phosphatase isoenzymes and modulation of activity. Braz. J. Med. Biol. Res., 41: 600-609.
    Direct Link  |  

  23. Keating, E., C. Lemos, P. Goncalves and F. Martel, 2008. Acute and chronic effects of some dietary bioactive compounds on folic acid uptake and on the expression of folic acid transporters by the human trophoblast cell line BeWo. J. Nutr. Biochem., 19: 91-100.
    CrossRef  |  

  24. Goncalves, P., J.R. Araujo, I. Azevedo and F. Martel, 2008. Lack of a significant effect of cannabinoids upon the uptake of 2-deoxy-D-glucose by Caco-2 cells. Pharmacology, 82: 30-37.
    CrossRef  |  

  25. Goncalves, P., J.R. Araujo and F. Martel, 2008. The effect of high glucose on SERT, the human plasmalemmal serotonin transporter. Nutr. Neurosci., 11: 244-250.
    CrossRef  |  

  26. Azenha, M.A., R. Evangelista, F. Martel and M.T. Vasconcelos, 2008. Estimate of the digestibility, assimilability and intestinal permeability of butyltins occurring in wine. Food Chem. Toxicol., 46: 767-773.
    CrossRef  |  

  27. Araujo, J.R., P. Goncalves and F. Martel, 2008. Modulation of glucose uptake in a human choriocarcinoma cell line (BeWo) by dietary bioactive compounds and drugs of abuse. J. Biochem., 144: 177-186.
    CrossRef  |  PubMed  |  Direct Link  |  

  28. Ribeiro, L., F. Martel and I. Azevedo, 2007. Short-term exposure to somatostatin or muscarinic agonists reduce acetylcholine-induced 3H-MPP+ release from bovine adrenal medullary cells. J. Biomed. Sci., 14: 347-355.
    CrossRef  |  

  29. Lemos, C., G.J. Peters, G. Jansen, F. Martel and C. Calhau, 2007. Modulation of folate uptake in cultured human colon adenocarcinoma Caco-2 cells by dietary compounds. Eur. J. Nutr., 46: 329-336.
    CrossRef  |  

  30. Keating, E., P. Goncalves, C. Lemos, F. Costa and I. Campos et al., 2007. Progesterone inhibits folic acid transport in human trophoblasts. J. Membrane Biol., 216: 143-152.
    CrossRef  |  

  31. Ribeiro, L., F. Martel and I. Azevedo, 2006. The release of 3H-1-methyl-4-phenylpyridinium from bovine adrenal chromaffin cells is modulated by somatostatin. Regul. Pept., 137: 107-113.
    CrossRef  |  

  32. Martel, F., P. Goncalves and I. Azevedo, 2006. Absorption of folate by Caco-2 cells is not affected by high glucose concentration. Eur. J. Pharmacol., 551: 19-26.
    CrossRef  |  

  33. Keating, E., C. Lemos, I. Azevedo and F. Martel, 2006. Comparison of folic acid uptake characteristics by human placental choriocarcinoma cells at acidic and physiological pH. Can. J. Physiol. Pharmacol., 84: 247-255.
    CrossRef  |  

  34. Keating, E., C. Lemos, I. Azevedo and F. Martel, 2006. Characteristics of thiamine uptake by the BeWo human trophoblast cell line. J. Biochem. Mol. Biol., 39: 383-393.
    Direct Link  |  

  35. Monteiro, R., C. Calhau, F. Martel, P. Guedes de Pinho and I. Azevedo, 2005. Intestinal uptake of MPP+ is differently affected by red and white wine. Life Sci., 76: 2483-2496.
    CrossRef  |  

  36. Monteiro, R., C. Calhau, F. Martel, A. Faria, N. Mateus and I. Azevedo, 2005. Modulation of MPP+ uptake by tea and some of its components in Caco-2 cells. Naunyn-Schmiedeberg's Arch. Pharmacol., 372: 147-152.
    CrossRef  |  

  37. Lemos, C., I. Azevedo and F. Martel, 2005. Effect of red wine on the intestinal absorption of thiamine and folate in the rat: Comparison with the effect of ethanol alone. Alcoholism: Clin. Exp. Res., 29: 664-671.
    CrossRef  |  

  38. Martel, F., R. Monteiro, C. Lemos and M.A. Vieira-Coelho, 2004. In vitro and in vivo effect of fluoxetine on the permeability of 3H-serotonin across rat intestine. Can. J. Physiol. Pharmacol., 82: 940-950.
    CrossRef  |  

  39. Keating, E., C. Lemos, R. Monteiro, I. Azevedo and F. Martel, 2004. The effect of a series of organic cations upon the plasmalemmal serotonin transporter, SERT. Life Sci., 76: 103-119.
    CrossRef  |  

  40. Azenha, M.A., R. Evangelista, F. Martel and M.T. Vasconcelos, 2004. Estimation of the human intestinal permeability of butyltin species using the Caco-2 cell line model. Food Chem. Toxicol., 42: 1431-1442.
    CrossRef  |  

  41. Martel, F., R. Monteiro and C. Lemos, 2003. Uptake of serotonin at the apical and basolateral membranes of human intestinal epithelial (Caco-2) cells occurs through the neuronal serotonin transporter (SERT). J. Pharmacol. Exp. Therapeut., 306: 355-362.
    CrossRef  |  

  42. Martel, F. and E. Keating, 2003. Uptake of 1-methyl4-phenylpyridinium (MPP+) by the JAR human placental choriocarcinoma cell line: Comparison with 5-hydroxytryptamine. Placenta, 24: 361-369.
    CrossRef  |  

  43. Calhau, C., F. Martel, C. Hipolito-Reis and I. Azevedo, 2003. Effect of thiamine on3 H-MPP+ uptake by Caco-2 cells. Pharmacol. Res., 48: 579-584.
    CrossRef  |  

  44. Ribeiro, L., I. Azevedo and F. Martel, 2002. Comparison of the effect of cyclic AMP on the content and release of dopamine and 1-methyl-4-phenylpyridinium (MPP+) in PC12 cells. Auton. Autacoid Pharmacol., 22: 277-289.
    CrossRef  |  

  45. Martel, F., E. Keating, C. Calhau and I. Azevedo, 2002. Uptake of (3)H-1-methyl-4-phenylpyridinium ((3)H-MPP(+)) by human intestinal Caco-2 cells is regulated by phosphorylation/dephosphorylation mechanisms. Biochem. Pharmacol., 63: 1565-1573.

  46. Martel, F., D. Grundemann and E. Schomig, 2002. A simple method for elimination of false positive results in RT-PCR. J. Biochem. Mol. Biol., 35: 248-250.
    PubMed  |  

  47. Calhau, C., F. Martel, S. Pinheiro-Silva, H. Pinheiro, P. Soares-da-Silva, C. Hipolito-Reis and I. Azevedo, 2002. Modulation of insulin transport in rat brain microvessel endothelial cells by an ecto-phosphatase activity. J. Cell. Biochem., 84: 389-400.
    CrossRef  |  

  48. Calhau, C., F. Martel, P. Soares-da-Silva, C. Hipolito-Reis and I. Azevedo, 2002. Regulation of [3H]MPP+ transport by phosphorylation/dephosphorylation pathways in RBE4 cells: Role of ecto-alkaline phosphatase. Naunyn-Schmiedeberg's Arch. Pharmacol., 365: 349-356.
    CrossRef  |  

  49. Calhau, C., F. Martel, C. Hipolito-Reis and I. Azevedo, 2002. Modulation of uptake of organic cationic drugs in cultured human colon adenocarcinoma Caco-2 cells by an ecto-alkaline phosphatase activity. J. Cell. Biochem., 87: 408-416.
    PubMed  |  

  50. Martel, F., E. Keating, C. Calhau, D. Grundemann, E. Schomig and I. Azevedo, 2001. Regulation of human extraneuronal monoamine transporter (hEMT) expressed in HEK293 cells by intracellular second messenger systems. Naunyn-Schmiedeberg's Arch. Pharmacol., 364: 487-495.
    PubMed  |  

  51. Martel, F., E. Keating and I. Azevedo, 2001. Effect of P-glycoprotein modulators on the human extraneuronal monoamine transporter. Eur. J. Pharmacol., 422: 31-37.
    CrossRef  |  Direct Link  |  

  52. Martel, F., D. Grundemann, C. Calhau and E. Schomig, 2001. Apical uptake of organic cations by human intestinal Caco-2 cells: Putative involvement of ASF transporters. Naunyn-Schmiedeberg's Arch. Pharmacol., 363: 40-49.
    CrossRef  |  

  53. Martel, F., C. Calhau, P. Soares-da-Silva and I. Azevedo, 2001. Transport of [3H]MPP+ in an immortalized rat brain microvessel endothelial cell line (RBE 4). Naunyn-Schmiedeberg's Arch. Pharmacol., 363: 1-10.
    CrossRef  |  Direct Link  |  

  54. Martel, F., C. Calhau and I. Azevedo, 2000. Characterization of the transport of the organic cation [3H]MPP+ in human intestinal epithelial (Caco-2) cells. Naunyn-Schmiedeberg's Arch. Pharmacol., 361: 505-513.
    CrossRef  |  

  55. Calhau, C., F. Martel, D. Moura and I. Azevedo, 2000. Somatostatin inhibits the release of noradrenaline induced by electrical stimulation of the rat mesenteric artery. Pharmacol. Res., 41: 497-501.
    CrossRef  |  Direct Link  |  

  56. Calhau, C., F. Martel, C. Hipolito-Reis and I. Azevedo, 2000. Effect of P-glycoprotein modulators on alkaline phosphatase activity in cultured rat hepatocytes. Cell. Physiol. Biochem., 10: 195-202.
    PubMed  |  

  57. Calhau, C., F. Martel, C. Hipolito-Reis and I. Azevedo, 2000. Differences between duodenal and jejunal rat alkaline phosphatase. Clin. Biochem., 33: 571-577.
    CrossRef  |  Direct Link  |  

  58. Martel, F., L. Ribeiro, C. Calhau and I. Azevedo, 1999. Inhibition by levamisole of the organic cation transporter rOCT1 in cultured rat hepatocytes. Pharmacol. Res., 40: 275-279.
    CrossRef  |  Direct Link  |  

  59. Martel, F., L. Ribeiro, C. Calhau and I. Azevedo, 1999. Comparison between uptake2 and rOCT1: Effects of catecholamines, metanephrines and corticosterone. Naunyn-Schmiedeberg's Arch. Pharmacol., 359: 303-309.
    CrossRef  |  Direct Link  |  

  60. Martel, F., L. Ribeiro, C. Calhau and I. Azevedo, 1999. Characterization of the efflux of the organic cation MPP+ in cultured rat hepatocytes. Eur. J. Pharmacol., 379: 211-218.
    CrossRef  |  Direct Link  |  

  61. Schomig, E., F. Spitzenberger, M. Engelhardt, F. Martel, N. Ording and D. Grundemann, 1998. Molecular cloning and characterization of two novel transport proteins from rat kidney. FEBS Lett., 425: 79-86.
    CrossRef  |  

  62. Martel, F., M.J. Martins, C. Calhau, C. Hipolito-Reis and I. Azevedo, 1998. Postnatal development of organic cation transport in the rat live. Pharmacol. Res., 37: 131-136.
    PubMed  |  

  63. Martel, F., C. Calhau, M.J. Martins and I. Azevedo, 1998. Uptake of [3H]-adrenaline by freshly isolated rat hepatocytes: Putative involvement of P-glycoprotein. J. Auton. Pharmacol., 18: 57-64.
    CrossRef  |  

  64. Martel, F., C. Calhau and C. Hipolito-Reis, 1998. Effect of bile duct obstruction on hepatic uptake of 1-methyl-4-phenylpyridinium in the rat. Pharmacol. Res., 37: 497-504.
    CrossRef  |  Direct Link  |  

  65. Grundemann, D., J. Babin-Ebell, F. Martel, N. Ording, A. Schmidt and E. Schomig, 1997. Primary structure and functional expression of the apical organic cation transporter from kidney epithelial LLC-PK1 cells. J. Biol. Chem., 272: 10408-10413.
    PubMed  |  

  66. Calhau, C., F. Martel, M.N.M.P. Alcada and I. Azevedo, 1997. Prevention by a somatostatin analogue of the hypertensive and cardiovascular structural changes induced by blockade of adenosine receptors. J. Auton. Pharmacol., 17: 243-247.
    CrossRef  |  

  67. Russ, H., K. Staust, F. Martel, M. Gliese and E. Schomig, 1996. The extraneuronal transporter for monoamine transmitters exists in cells derived from human central nervous system glia. Eur. J. Neurosci., 8: 1256-1264.
    CrossRef  |  

  68. Martel, F., T. Vetter, H. Russ, D. Grundemann, I. Azevedo, H. Koepsell and E. Schomig, 1996. Transport of small organic cations in the rat liver. The role of the organic cation transporter OCT1. Naunyn-Schmiedeberg's Arch. Pharmacol., 354: 320-326.
    CrossRef  |  Direct Link  |  

  69. Martel, F., M.J. Martins, C. Hipolito-Reis and I. Azevedo, 1996. Inward transport of [3H]-1-methyl-4-phenylpyridinium in rat isolated hepatocytes: Putative involvement of a P-glycoprotein transporter. Br. J. Pharmacol., 119: 1519-1524.
    PubMed  |  

  70. Martel, F., M.J. Martins and I. Azevedo, 1996. Inward transport of 3H-MPP+ in freshly isolated rat hepatocytes: Evidence for interaction with catecholamines. Naunyn-Schmiedeberg's Arch. Pharmacol., 354: 305-311.
    PubMed  |  

  71. Martel, F. and I. Azevedo, 1995. The fate of [3H]-(−)-noradrenaline in the perfused rat liver. J. Auton. Pharmacol., 15: 309-319.
    CrossRef  |  

  72. Martel, F., I. Azevedo and W. Osswald, 1994. Uptake of 3H-catecholamines by rat liver cells occurs mainly through a system which is distinct from uptake1 or uptake2. Naunyn-Schmiedeberg's Arch. Pharmacol., 350: 130-135.
    CrossRef  |  

  73. De Almeida, J.A.F., F. Martel, I. Azevedo and W. Osswald, 1994. Metabolism of [3H]noradrenaline by umbilical arteries and placental bed tissue obtained from normotensive and preeclamptic human pregnancies. J. Matern. Fetal. Invest., 4: 81-85.

  74. Martel, F., I. Azevedo and W. Osswald, 1993. Uptake and metabolism of 3H-adrenaline and 3H-noradrenaline by isolated hepatocytes and liver slices of the rat. Naunyn-Schmiedeberg's Arch. Pharmacol., 348: 450-457.
    CrossRef  |  

  75. Martel, F., I. Azevedo and W. Osswald, 1993. Extraneuronal uptake and O-methylation of 3H-adrenaline in the rabbit aorta. Naunyn-Schmiedeberg's Arch. Pharmacol., 347: 363-370.
    PubMed  |  

  76. Branco, D., M. Caramona, F. Martel, J.A.F. de Almeida and W. Osswald, 1992. Predominance of oxidative deamination in the metabolism of exogenous noradrenaline by the normal and chemically denervated human uterine artery. Naunyn-Schmiedeberg's Arch. Pharmacol., 346: 286-293.
    CrossRef  |  

  77. Borges, N., F. Martel, D. Branco and W. Osswald, 1992. Effects of nebivolol stereoisomers on the action of adrenaline on blood pressure, heart rate and blood levels of noradrenaline and DOPEG. J. Auton. Pharmacol., 12: 441-448.
    PubMed  |  

  78. Albino-Teixeira, A., I. Azevedo, F. Martel and W. Osswald, 1991. Superoxide dismutase partially prevents sympathetic denervation by 6-hydroxydopamine. Naunyn-Schmiedeberg's Arch. Pharmacol., 344: 36-40.
    CrossRef  |