Dr. Pedro Miguel Ribeiro Viana Baptista

Dr. Pedro Miguel Ribeiro Viana Baptista

Associate Professor
Universidade Nova de Lisboa, Portugal


Highest Degree
Ph.D. in Human Molecular Genetics from University of London, UK

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Area of Interest:

Molecular Sciences
100%
Molecular Genetics
62%
Biotechnology
90%
Nanodiagnostics
75%
Gene Therapy
55%

Education

2000

Ph.D.

University of London, UK

Human Molecular Genetics

Selected Publications

  1. Veigas, B., R. Branquinho, J.V. Pinto, P.J. Wojcik, R. Martins, E. Fortunato and P.V. Baptista, 2014. Ion sensing (EIS) real-time quantitative monitorization of isothermal DNA amplification. Biosens. Bioelectron., 52: 50-55.
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  2. Quaresma, P., I. Osorio, G. Doria, P.A. Carvalho and A. Pereira et al., 2014. Star-shaped magnetite@gold nanoparticles for protein magnetic separation and SERS detection. RSC Adv., 4: 3659-3667.
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  3. Conde, J., M. Larguinho, A. Cordeiro, L.R. Raposo and P.M. Costa et al., 2014. Gold-Nanobeacons for gene therapy: evaluation of genotoxicity, cell toxicity and proteome profiling analysis. Nanotoxicology, 8: 521-532.
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  4. Veigas, B., P. Pedrosa, I. Couto, M. Viveiros and P.V. Baptista, 2013. Isothermal DNA amplification coupled to Au-nanoprobes for detection of mutations associated to Rifampicin resistance in Mycobacterium tuberculosis. J. Nanobiotechnol., Vol. 11. 10.1186/1477-3155-11-38.
    CrossRef  |  Direct Link  |  

  5. Larguinho, M., P.M. Costa, G. Sousa, M.H. Costa, M.S. Diniz and P.V. Baptista, 2013. Histopathological findings on Carassius auratus hepatopancreas upon exposure to acrylamide: Correlation with genotoxicity and metabolic alterations. J. Applied Toxicol. (In Press). 10.1002/jat.2936.
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  6. Larguinho, M., J.L. Capelo and P.V. Baptista, 2013. Fast nucleotide identification through fingerprinting using gold nanoparticle-based surface-assisted laser desorption/ionization. Talanta, 105: 417-421.
    CrossRef  |  Direct Link  |  

  7. Cordeiro, M., L. Giestas, J.C. Lima and P. Baptista, 2013. Coupling an universal primer to SBE combined spectral codification strategy for single nucleotide polymorphism analysis. J. Biotechnol., 168: 90-94.
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  8. Conde, J., J.M. de la Fuente and P.V. Baptista, 2013. Nanomaterials for reversion of multidrug resistance in cancer: A new hope for an old idea? Front. Pharmacol., Vol. 4. 10.3389/fphar.2013.00134.
    CrossRef  |  Direct Link  |  

  9. Conde, J., J. Rosa, J.M. de la Fuente and P.V. Baptista, 2013. Gold-nanobeacons for simultaneous gene specific silencing and intracellular tracking of the silencing events. Biomaterials, 34: 2516-2523.
    CrossRef  |  

  10. Conde, J., F. Tian, Y. Hernandez, C. Bao and D. Cui et al., 2013. In vivo tumor targeting via nanoparticle-mediated therapeutic siRNA coupled to inflammatory response in lung cancer mouse models. Biomaterials, 34: 7744-7753.
    CrossRef  |  PubMed  |  Direct Link  |  

  11. Carlos, F.F., J. Silva-Nunes, O. Flores, M. Brito, G. Doria, L. Veiga and P.V. Baptista, 2013. Association of FTO and PPARG polymorphisms with obesity in Portuguese women. Diabetes Metab. Syndrome Obesity, 6: 241-245.
    CrossRef  |  Direct Link  |  

  12. Cabral, R.M. and P.V. Baptista, 2013. The chemistry and biology of gold nanoparticle-mediated photothermal therapy: Promises and challenges. Nano Life, Vol. 3, No. 3. 10.1142/S179398441330001X.
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  13. Branquinho, R., J.V. Pinto, T. Busani, P. Barquinha and L. Pereira et al., 2013. Plastic compatible sputtered Ta2O5 sensitive layer for oxide semiconductor TFT sensors. J. Display Technol., 9: 723-728.
    CrossRef  |  Direct Link  |  

  14. Bernacka-Wojcik, I., P. Lopes, A.C. Vaz, B. Veigas and P.J. Wojcik et al., 2013. Bio-microfluidic platform for gold nanoprobe based DNA detection: Application to Mycobacterium tuberculosis. Biosens. Bioelectron., 48: 87-93.
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  15. Veigas, B., J.M. Jacob, M.N. Costa, D.S. Santos and M. Viveiros et al., 2012. Gold on paper-paper platform for Au-nanoprobe TB detection. Lab Chip, 12: 4802-4808.
    CrossRef  |  PubMed  |  

  16. Sanz, V., J. Conde, Y. Hernandez, P.V. Baptista, M.R. Ibarra and J.M. de la Fuente, 2012. Effect of PEG biofunctional spacers and TAT peptide on dsRNA loading on gold nanoparticles. J. Nanoparticle Res., Vol. 14. 10.1007/s11051-012-0917-2.
    CrossRef  |  Direct Link  |  

  17. Rosa, J., J. Conde, J.M. de la Fuente, J.C. Lima and P.V. Baptista, 2012. Gold-nanobeacons for real-time monitoring of RNA synthesis. Biosens. Bioelectron., 36: 161-167.
    CrossRef  |  Direct Link  |  

  18. Machado, D., I. Couto, J. Perdigao, L. Rodrigues and I. Portugal et al., 2012. Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis. PLoS ONE, Vol. 7. 10.1371/journal.pone.0034538.
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  19. Larguinho, M. and P.V. Baptista, 2012. Gold and silver nanoparticles for clinical diagnostics: From genomics to proteomics. J. Proteomics, 75: 2811-2823.
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  20. Guirgis, B.S.S., C. Sa e Cunha, I. Gomes, M. Cavadas and I. Silva et al., 2012. Gold nanoparticle-based fluorescence immunoassay for Malaria antigen detection. Anal. Bioanal. Chem., 402: 1019-1027.
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  21. Dos Santos, M.M., M.J. Queiroz and P.V. Baptista, 2012. Enhancement of antibiotic effect via gold: Silver-alloy nanoparticles. J. Nanoparticle Res., Vol. 14. 10.1007/s11051-012-0859-8.
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  22. Doria, G., J. Conde, B. Veigas, L. Giestas and C. Almeida et al., 2012. Noble metal nanoparticles for biosensing applications. Sensors, 12: 1657-1687.
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  23. Conde, J., P.V. Baptista, Y. Hernandez, V. Sanz and J.M. de la Fuente, 2012. Modification of plasmid DNA topology by histone-mimetic gold nanoparticles. Nanomedicine, 7: 1657-1666.
    CrossRef  |  PubMed  |  Direct Link  |  

  24. Conde, J., J. Rosa, J.C. Lima and P.V. Baptista, 2012. Nanophotonics for molecular diagnostics and therapy applications. Int. J. Photoenergy. 10.1155/2012/619530.
    CrossRef  |  Direct Link  |  

  25. Conde, J., G. Doria, J.M. de la Fuente, P.V. Baptista, 2012. RNA Quantification using Noble Metal Nanoprobes-Application to Cancer Diagnostics. In: Nanoparticles in Biology and Medicine: Methods and Protocols (Methods in Molecular Biology, Volume 906), Soloviev, M. (Ed.). Chapter 6, Humana Press, USA., ISBN-13: 9781617799525, pp: 71-87.

  26. Conde, J., G. Doria and P. Baptista, 2012. Noble metal nanoparticles applications in cancer. J. Drug Delivery. 10.1155/2012/751075.
    CrossRef  |  Direct Link  |  

  27. Conde, J., A. Ambrosone, V. Sanz, Y. Hernandez and V. Marchesano et al., 2012. Design of multifunctional gold nanoparticles for in vitro and in vivo gene silencing. ACS Nano, 6: 8316-8324.
    CrossRef  |  Direct Link  |  

  28. Baptista, P.V., 2012. RNA quantification with gold nanoprobes for cancer diagnostics. Clin. Lab. Med., 32: 1-13.
    CrossRef  |  Direct Link  |  

  29. Baptista, P.V., 2012. Could gold nanoprobes be an important tool in cancer diagnostics? Expert Rev. Mol. Diagn., 12: 541-543.
    CrossRef  |  Direct Link  |  

  30. Veigas, B., G. Doria and P.V. Baptista, 2011. Nanodiagnostics for Tuberculosis. In: Understanding Tuberculosis: Global Experiences and Innovative Approaches to the Diagnosis, Cardona, P.J. (Ed.). Chapter 12, InTech Publishers, Rijeka, Croatia, ISBN: 978-953-307-938-7, pp: 257-276.
    Direct Link  |  

  31. Rosa, J.P., J.C. Lima and P.V. Baptista, 2011. Experimental photophysical characterization of fluorophores in the vicinity of gold nanoparticles. Nanotechnology, Vol. 22. 10.1088/0957-4484/22/41/415202.
    CrossRef  |  Direct Link  |  

  32. Giestas, L., J.C. Lima and P.V. Baptista, 2011. Coupling single base extension to a spectral codification tool for increased throughput screening. J. Biotechnol., 154: 199-204.
    CrossRef  |  Direct Link  |  

  33. Branquinho, R., B. Veigas, J.V. Pinto, R. Martins, E. Fortunato and P.V. Baptista, 2011. Real-time monitoring of PCR amplification of proto-oncogene c-MYC using a Ta2O5 electrolyte-insulator-semiconductor sensor. Biosens. Bioelectron., 28: 44-49.
    CrossRef  |  Direct Link  |  

  34. Baptista, P.V., G. Doria, P. Quaresma, M. Cavadas and C.S. Neves et al., 2011. Nanoparticles in molecular diagnostics. Prog. Mol. Biol. Transl. Sci., 104: 427-488.
    CrossRef  |  PubMed  |  Direct Link  |  

  35. Baptista, P.V., G. Doria, P. Quaresma, M. Cavadas and C.S. Neves et al., 2011. Nanoparticles in Molecular Diagnostics. In: Progress in Molecular Biology and Translational Science, Volume 104: Nanoparticles in Translational Science and Medicine, Villaverde, A. (Ed.). Chapter 11, Academic Press, USA., ISBN-13: 9780124160200, pp: 427-488.

  36. Veigas, B., D. Machado, J. Perdigao, I. Portugal, I. Couto, M. Viveiros and P.V. Baptista, 2010. Au-nanoprobes for detection of SNPs associated with antibiotic resistance in Mycobacterium tuberculosis. Nanotechnology, Vol. 21. 10.1088/0957-4484/21/41/415101.
    CrossRef  |  Direct Link  |  

  37. Silva, L.B., B. Veigas, G. Doria, P. Costa and J. Inacio et al., 2010. Portable optoelectronic biosensing platform for identification of mycobacteria from the Mycobacterium tuberculosis complex. Biosens. Bioelectron., 26: 2012-2017.
    CrossRef  |  Direct Link  |  

  38. Pinheiro, A.V., J. Conde, A.J. Parola, J.C. Lima and P.V. Baptista, 2010. Use of cyclodextrins as scavengers of inhibitory photo-products in light controlled in vitro synthesis of RNA. J. Photochem. Photobiol. A: Chem., 213: 147-151.
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  39. Pinheiro, A.V., A.J. Parola, P.V. Baptista and J.C. Lima, 2010. pH effect on the photochemistry of 4-methylcoumarin phosphate esters: Caged-phosphate case study. J. Phys. Chem. A, 114: 12795-12803.
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  40. Neves, C.S., P. Quaresma, P.V. Baptista, P.A. Carvalho, J.P. Araujo, E. Pereira and P. Eaton, 2010. New insights into the use of magnetic force microscopy to discriminate between magnetic and nonmagnetic nanoparticles. Nanotechnology, Vol. 21. 10.1088/0957-4484/21/30/305706.
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  41. Larguinho, M., H.M. Santos, G. Doria, H. Scholz, P.V. Baptista and J.L. Capelo, 2010. Development of a fast and efficient ultrasonic-based strategy for DNA fragmentation. Talanta, 81: 881-886.
    CrossRef  |  

  42. Doria, G., M. Larguinho, J.T. Dias, E. Pereira, R. Franco and P.V. Baptista, 2010. Gold-silver-alloy nanoprobes for one-pot multiplex DNA detection. Nanotechnology, Vol. 21. 10.1088/0957-4484/21/25/255101.
    CrossRef  |  Direct Link  |  

  43. Doria, G., B.G. Baumgartner, R. Franco and P.V. Baptista, 2010. Optimizing Au-nanoprobes for specific sequence discrimination. Colloids Surf. B: Biointerfaces, 77: 122-124.
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  44. Costa, P., A. Amaro, A. Botelho, J. Inacio and P.V. Baptista, 2010. Gold nanoprobe assay for the identification of mycobacteria of the Mycobacterium tuberculosis complex. Clin. Microbiol. Infect., 16: 1464-1469.
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  45. Conde, J., J.M. de la Fuente and P.V. Baptista, 2010. RNA quantification using gold nanoprobes-application to cancer diagnostics. J. Nanobiotechnol., Vol. 8. 10.1186/1477-3155-8-5.
    CrossRef  |  Direct Link  |  

  46. Conde, J., J.M. de la Fuente and P.V. Baptista, 2010. In vitro transcription and translation inhibition via DNA functionalized gold nanoparticles. Nanotechnology, Vol. 21. 10.1088/0957-4484/21/50/505101.
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  47. Bernacka-Wojcik, I., R. Senadeera, P.J. Wojcik, L.B. Silva and G. Doria et al., 2010. Inkjet printed and doctor blade TiO2 photodetectors for DNA biosensors. Biosens. Bioelectron., 25: 1229-1234.
    CrossRef  |  Direct Link  |  

  48. Giestas, L., V. Petrov, P.V. Baptista and J.C. Lima, 2009. General FRET-based coding for application in multiplexing methods. Photochem. Photobiol. Sci., 8: 1130-1138.
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  49. Baptista, P.V., 2009. Cancer nanotechnology-prospects for cancer diagnostics and therapy. Curr. Cancer Therapy Rev., 5: 80-88.
    CrossRef  |  

  50. Silva, L.B., P.V. Baptista, L. Raniero, G. Doria, R. Martins and E. Fortunato, 2008. Characterization of optoelectronic platform using an amorphous/nanocrystalline silicon biosensor for the specific identification of nucleic acid sequences based on gold nanoparticle probes. Sens. Actuator B: Chem., 132: 508-511.
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  51. Pinheiro, A.V., P.V. Baptista and J.C. Lima, 2008. Light activation of transcription: photocaging of nucleotides for control over RNA polymerization. Nucleic Acids Res., Vol. 36. 10.1093/nar/gkn415.
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  52. Martins, R., P. Baptista, L. Silva, L.V. Raniero, G. Doria, R. Franco and E. Fortunato, 2008. Identification of unamplified genomic DNA sequences using gold nanoparticle probes and a novel thin film photodetector. J. Non-Cryst. Solids, 354: 2580-2584.
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  53. Giestas, L., G.N.M. Ferreira, P.V. Baptista and J.C. Lima, 2008. Multiplexed spectral coding for simultaneous detection of DNA hybridization reactions based on FRET. Sens. Actuator B: Chem., 134: 146-157.
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  54. Baptista, P.V., E. Pereira, P. Eaton, G. Doria and A. Miranda et al., 2008. Gold nanoparticles for the development of clinical diagnosis methods. Anal. Bioanal. Chem., 391: 943-950.
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  55. Martins, R., P.V. Baptista, L. Raniero, G. Doria, L. Silva, R. Franco and E. Fortunato, 2007. Amorphous/nanocrystalline silicon biosensor for the specific identification of unamplified nucleic acid sequences using gold nanoparticle probes. Applied Phys. Lett., Vol. 90. 10.1063/1.2431449.
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  56. Gaspar, J.F., P.V. Baptista and J. Rueff, 2007. Gold nanoparticle based systems in genetics. Curr. Pharmacogenomics, 5: 39-47.
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  57. Eaton, P., G. Doria, E. Pereira, P.V. Baptista and R. Franco, 2007. Imaging gold nanoparticles for DNA sequence recognition in biomedical applications. IEEE Trans. NanoBiosci., 6: 282-288.
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  58. Doria, G., R. Franco and P. Baptista, 2007. Nanodiagnostics: Fast colorimetric method for single nucleotide polymorphism/mutation detection. IET Nanobiotechnol., 1: 53-57.
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  59. Baptista, P.V., M. Koziol-Montewka, J. Paluch-Oles, G. Doria and R. Franco, 2006. Gold-nanoparticle-probe-based assay for rapid and direct detection of Mycobacterium tuberculosis DNA in clinical samples. Clin. Chem., 52: 1433-1434.
    CrossRef  |  Direct Link  |  

  60. Baptista, P.V., G. Doria, D. Henriques, E. Pereira and R. Franco, 2005. Colorimetric detection of eukaryotic gene expression with DNA-derivatized gold nanoparticles. J. Biotechnol., 119: 111-117.
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  61. Baptista, P.V., 2005. Principles in genetic risk assessment. Ther. Clin. Risk Manage., 1: 15-20.
    PubMed  |  

  62. Groet, J., J.H. Ives, A.P. South, P.R. Baptista and T.A. Jones et al., 1998. Bacterial contig map of the 21q11 region associated with Alzheimer's disease and abnormal myelopoiesis in down syndrome. Genome Res., 8: 385-389.
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  63. Flomen, R.H., R. Vatcheva, P.A. Gorman, P.R. Baptista and J. Groet et al., 1998. Construction and analysis of a sequence-ready map in 4q25: Rieger syndrome can be caused by haploinsufficiency of RIEG, but also by chromosome breaks ≈90 kb upstream of this gene. Genomics, 47: 409-413.
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