Dr. Gabor Szenasi
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Dr. Gabor Szenasi

Senior Research Fellow
Semmelweis University, Hungary

Highest Degree
Ph.D. in Biology from Hungarian Academy of Sciences, Hungary

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Area of Interest:

Pharmacology and Toxicology
100%
Cardiovascular Pharmacology
62%
Nanomedicine
90%
Chronobiology
75%
Nephrology
55%

Research Publications in Numbers

Books
0
Chapters
1
Articles
150
Abstracts
3

Selected Publications

  1. Tod, P., N. Farkas, D. Németh, G. Szénási and Á. Vincze et al., 2021. Initial renal function (EGFR) is a prognostic marker of severe acute pancreatitis: a cohort-analysis of 1,224 prospectively collected cases. Front. Med., Vol. 8. 10.3389/fmed.2021.671917.
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  2. Róka, B., P. Tod, T. Kaucsár, É.N. Bukosza and I. Vörös et al., 2021. Delayed contralateral nephrectomy halted post-ischemic renal fibrosis progression and inhibited the ischemia-induced fibromir upregulation in mice. Biomedicine, Vol. 9. 10.3390/biomedicines9070815.
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  3. Révész, C., A.A. Wasik, M. Godó, P. Tod, S. Lehtonen, G. Szénási and P. Hamar, 2021. Cold saline perfusion before ischemia-reperfusion is harmful to the kidney and is associated with the loss of ezrin, a cytoskeletal protein, in rats. Biomed., Vol. 9. 10.3390/biomedicines9010030.
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  4. Milosevits, G., T. Mészáros, E. Őrfi, T. Bakos and M. Garami et al., 2021. Complement-mediated hypersensitivity reactions to an amphotericin B-containing lipid complex (Abelcet) in pediatric patients and anesthetized rats: benefits of slow infusion. Nanomed. Nanotechnol., Biol. Med., Vol. 34. 10.1016/j.nano.2021.102366.
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  5. Kaucsár, T., B. Róka, P. Tod, P.T. Do, Z. Hegedűs, G. Szénási and P. Hamar, 2021. Divergent regulation of lncRNA expression by ischemia in adult and aging mice. GeroSci., 10.1007/s11357-021-00460-9.
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  6. Harsing, L.G., G. Szénási, T. Zelles and L. Köles, 2021. Purinergic–glycinergic interaction in neurodegenerative and neuroinflammatory disorders of the retina. Int. J. Mol. Sci., Vol. 22. 10.3390/ijms22126209.
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  7. Vereckei, A., A. Simon, G. Szénási, G. Katona and L. Hankó et al., 2020. Usefulness of a novel electrocardiographic score to estimate the pre-test probability of acute pulmonary embolism. Am. J. Cardiol., 130: 143-151.
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  8. Tod, P., E.N. Bukosza, B. Róka, T. Kaucsár and A. Fintha et al., 2020. Post-ischemic renal fibrosis progression is halted by delayed contralateral nephrectomy: the involvement of macrophage activation. Int. J. Mol. Sci., Vol. 21. 10.3390/ijms21113825.
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  9. Tod, P., B. Róka, T. Kaucsár, K. Szatmári and M. Vizovišek et al., 2020. Time-dependent miRNA profile during septic acute kidney injury in mice. Int. J. Mol. Sci., Vol. 21. 10.3390/ijms21155316.
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  10. Szentmihu00e1lyi, K., A. Blu00e1zovics, Z. May, M. Mohai and K. Su00fcle et al., 2020. Metal element alteration in the lung by cisplatin and CV247 administration. Biomed. Pharmacother., 10.1016/j.biopha.2020.110307.
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  11. Bukosza, E.N., C. Kornauth, K. Hummel, H. Schachner and N. Huttary et al., 2020. ECM characterization reveals a massive activation of acute phase response during FSGS. Int. J. Mol. Sci., Vol. 21. 10.3390/ijms21062095.
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  12. Őrfi, E., T. Mészáros, M. Hennies, T. Fülöp and L. Dézsi et al., 2019. Acute physiological changes caused by complement activators and amphotericin B-containing liposomes in mice. Int. J. Nanomed., 14: 1563-1573.
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  13. Szabó, É., G. Koványi-Lax, G. Szénási, A. Dancsó and L. Kiss et al., 2019. A novel tool for structure assignment of hydroxylated metabolites of (arylpiperazinylbutyl)oxindole derivatives based on relative HPLC retention times. J. Pharm. Biomed. Anal., 170: 102-111.
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  14. Róka, B., P. Tod, T. Kaucsár, M. Vizovišek and R. Vidmar et al., 2019. The acute phase response is a prominent renal proteome change in sepsis in mice. Int. J. Mol. Sci., Vol. 21. 10.3390/ijms21010200.
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  15. Dézsi, L., T. Mészáros, E. Őrfi, T. Fülöp and M. Hennies et al., 2019. Complement activation-related pathophysiological changes in anesthetized rats: activator-dependent variations of symptoms and mediators of pseudoallergy. Molecules, Vol. 24. 10.3390/molecules24183283.
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  16. Bukosza, E.N., T. Kaucsár, M. Godó, E. Lajtár and P. Tod et al., 2019. Glomerular collagen deposition and lipocalin-2 expression are early signs of renal injury in prediabetic obese rats. Int. J. Mol. Sci., Vol. 20. 10.3390/ijms20174266.
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  17. Baska, F., A. Sipos, Z. Őrfi, Z. Nemes and J. Dobos et al., 2019. Discovery and development of extreme selective inhibitors of the ITD and D835Y mutant FLT3 kinases. Eur. J. Medic. Chem., Vol. 184. 10.1016/j.ejmech.2019.111710.
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  18. Nagy, C.T., G. Koncsos, Z.V. Varga, T. Baranyai and S. Tuza et al., 2018. Selegiline reduces adiposity induced by high-fat, high-sucrose diet in male rats. Br. J. Pharmacol., 175: 3713-3726.
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  19. Kölling, M., T. Kaucsar, C. Schauerte, A. Hübner and A. Dettling et al., 2017. Therapeutic MIR-21 silencing ameliorates diabetic kidney disease in mice. Mol. Ther., 25: 165-180.
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  20. Kökény, G., L. Fang, C. Révész, M.M. Mózes, P. Vörös, G. Szénási and L. Rosivall, 2017. The effect of combined treatment with the (pro)renin receptor blocker hrp and quinapril in type 1 diabetic rats. Kidney Blood Pressure Res., 42: 109-122.
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  21. Gacsályi, I., K. Móricz, G. Gigler, J. Wellmann and K. Nagy et al., 2017. Behavioural pharmacology of the α5-gaba a receptor antagonist s44819: enhancement and remediation of cognitive performance in preclinical models. Neuropharmacology, 125: 30-38.
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  22. Czirok, S., L. Fang, T. Radovits, G. Szabó and G. Szénási et al., 2017. Cinaciguat ameliorates glomerular damage by reducing ERK1/2 activity and TGF-ß expression in type-1 diabetic rats. Sci. Rep., 10.1038/s41598-017-10125-3.
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  23. Vereckei, A., Z. Szelényi, V. Kutyifa, E. Zima and G. Szénási et al., 2016. Novel electrocardiographic dyssynchrony criteria improve patient selection for cardiac resynchronization therapy. EP Europace, 20: 97-103.
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  24. Kaucsár, T., M. Godó, C. Révész, M. Kovács and A. Mócsai et al., 2016. Urine/plasma neutrophil gelatinase associated lipocalin ratio is a sensitive and specific marker of subclinical acute kidney injury in mice. PLoS ONE, 10.1371/journal.pone.0148043.
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  25. Fazakas, Á., Z. Szelényi, G. Szénási, G. Nyírő and P.M. Szabó et al., 2016. Genetic predisposition in patients with hypertension and normal ejection fraction to oxidative stress. J. Am. Soc. Hypertens., 10: 124-132.
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  26. Szelényi, Z., Á. Fazakas, G. Szénási, N. Tegze and B. Fekete et al., 2015. The mechanism of reduced longitudinal left ventricular systolic function in hypertensive patients with normal ejection fraction. J. Hypertens., 33: 1962-1969.
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  27. Szalay, C.I., K. Erdélyi, G. Kökény, E. Lajtár and M. Godó et al., 2015. Oxidative/nitrative stress and inflammation drive progression of doxorubicin-induced renal fibrosis in rats as revealed by comparing a normal and a fibrosis-resistant rat strain. PLoS ONE, 10.1371/journal.pone.0127090.
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  28. Ling, I., B. Mihalik, L.A. Etherington, G. Kapus and A. Pálvölgyi et al., 2015. A novel gabaa alpha 5 receptor inhibitor with therapeutic potential. Eur. J. Pharmacol., 764: 497-507.
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  29. Szentmihalyi, K., Z. May, G. Szenasi, C. Mathe, A. Sebesteny, M. Albert and A. Blazovics, 2014. Cisplatin administration influences on toxic and non-essential element metabolism in rats. J. Trace Elements Med. Biol., 28: 317-321.
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  30. Kaucsar, T., C. Bodor, M. Godo, C. Szalay and C. Revesz et al., 2014. LPS-induced delayed preconditioning is mediated by Hsp90 and involves the heat shock response in mouse kidney. PloS ONE, Vol. 9. 10.1371/journal.pone.0092004.
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  31. Dezsi, L., T. Fulop, T. Meszaros, G. Szenasi and R. Urbanics et al., 2014. Features of complement activation-related pseudoallergy to liposomes with different surface charge and PEGylation: Comparison of the porcine and rat responses. J. Controlled Release, 195: 2-10.
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  32. Mathe, C., G. Szenasi, A. Sebesteny, A. Blazovics, K. Szentmihalyi, P. Hamar and M. Albert, 2013. Protective effect of CV247 against cisplatin nephrotoxicity in Hum. Exp. Toxicol., 33: 789-799.
    CrossRef  |  PubMed  |  Direct Link  |  
  33. Harsing, L.G., M. Albert, P. Matyus and G. Szenasi, 2012. Inhibition of hypoxia-induced [3H]glycine release from chicken retina by the glycine transporter type-1 (GlyT-1) inhibitors NFPS and Org-24461. Exp. Eye Res., 94: 6-12.
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  34. Volk, B., I. Gacsalyi, K. Pallagi, L. Poszavacz, I. Gyonos and E. Szaba et al., 2011. Optimization of (Arylpiperazinylbutyl)oxindoles exhibiting selective 5-HT7 receptor antagonist activity. J. Med. Chem., 54: 6657-6669.
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  35. Szentandrassy, N., G. Harmati, V. Farkas, B. Horvath and B. Hegyi et al., 2011. Modified cAMP derivatives: Powerful tools in heart research. Curr. Med. Chem., 18: 3729-3736.
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  36. Kovacs, A.D., A. Saje, A. Wong, G. Szenasi and P. Kiricsi et al., 2011. Temporary inhibition of AMPA receptors induces a prolonged improvement of motor performance in a mouse model of juvenile Batten disease. Neuropharmacology, 60: 405-409.
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  37. Harmati, G., T. Banyasz, L. Barandi, N. Szentandrassy and B. Horvath et al., 2011. Effects of β-adrenoceptor stimulation on delayed rectifier K+ currents in canine ventricular cardiomyocytes. Br. J. Pharmacol., 162: 890-896.
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  38. Kovacs, A., K. Moricz, M. Albert, A. Benedek, L.G. Harsing Jr. and G. Szenasi, 2010. Decreased vasoconstrictor responses in remote cerebral arteries after focal brain ischemia and reperfusion in the rat, in vitro. Eur. J. Pharmacol., 644: 154-159.
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  39. Vereckei, A., G. Duray, G. Szenasi, G.T. Altemose and J.M. Miller, 2008. New algorithm using only lead aVR for differential diagnosis of wide QRS complex tachycardia. Heart Rhythm., 5: 89-98.
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  40. Szenasi, G., M. Vegh, G. Szabo, S. Kertesz and G. Kapus et al., 2008. 2,3-Benzodiazepine-type AMPA receptor antagonists and their neuroprotective effects. Neurochem. Int., 52: 166-183.
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  41. Sas, K., H. Robotka, E. Rozsa, M. Agoston and G. Szenasi et al., 2008. Kynurenine diminishes the ischemia-induced histological and electrophysiological deficits in the rat hippocampus. Neurobiol. Dis., 32: 302-308.
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  42. Kompagne, H., G. Bardos, G. Szenasi, I. Gacsalyi, L.G. Harsing Jr. and G. Levay, 2008. Chronic mild stress generates clear depressive but ambiguous anxiety-like behaviour in rats. Behav. Brain Res., 193: 311-314.
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  43. Vereckei, A., G. Duray, G. Szenasi, G.T. Altemose and J.M. Miller, 2007. Application of a new algorithm in the differential diagnosis of wide QRS complex tachycardia. Eur. Heart J., 28: 589-600.
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  44. Gigler, G., K. Moricz, M. Agoston, A. Simo and M. Albert et al., 2007. Neuroprotective and anticonvulsant effects of EGIS-8332, a non-competitive AMPA receptor antagonist, in a range of animal models. Br. J. Pharmacol., 152: 151-160.
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  45. Gigler, G., G. Szenasi, A. Simo, G. Levay and L.G. Harsing Jr., et al., 2007. Neuroprotective effect of L-kynurenine sulfate administered before focal cerebral ischemia in mice and global cerebral ischemia in Gerbils. Eur. J. Pharmacol., 564: 116-122.
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  46. Matucz, E., K. Moricz, G. Gigler, A. Benedek and J. Barkoczy et al., 2006. Therapeutic time window of neuroprotection by non-competitive AMPA antagonists in transient and permanent focal cerebral ischemia in rats. Brain Res., 1123: 60-67.
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  47. Benedek, A., K. Moricz, Z. Juranyi, G. Gigler and G. Levay et al., 2006. Albert M. Use of TTC staining for the evaluation of tissue injury in the early phases of reperfusion after focal cerebral ischemia in rats. Brain Res., 1116: 159-165.
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