Dr. Ilona  Petrikovics

Dr. Ilona Petrikovics

Associate Professor
Sam Houston State University, USA


Highest Degree
Ph.D. in Medicinal Biology from University Medical School, Hungary

Share this Profile

Area of Interest:

Biomedical Sciences
100%
Enzyme Mechanism
62%
Drug Antagonism
90%
Drug Formulation
75%
Medical Education
55%

Education

2006

Ph.D.

University Medical School, Hungary

Medicinal Biology

Selected Publications

  1. Wijesooriya, C., M. Budai, L. Budai, M.E. Szilasi and I. Petrikovics, 2013. Optimization of liposomal encapsulation for ceftazidime for developing a potential eye drop formulation. J. Basic Clin. Pharm., 4: 73-75.
    CrossRef  |  PubMed  |  Direct Link  |  

  2. Marziaz, M.L., K. Frazier, P.B. Guidry, R.A. Ruiz, I. Petrikovics and D.C. Haines, 2013. Comparison of brain mitochondrial cytochrome c oxidase activity with cyanide LD50 yields insight into the efficacy of prophylactics. J. Applied Toxicol., 33: 50-55.
    CrossRef  |  PubMed  |  Direct Link  |  

  3. Kovacs, K., M. Ancha, M. Jane, S. Lee and S. Angalakurthi et al., 2013. Identification, Solubility enhancement and in vivo testing of a cyanide antidote candidate. Eur. J. Pharm. Sci., 49: 352-358.
    CrossRef  |  PubMed  |  Direct Link  |  

  4. Budai, L., N. Kaszas, P. Grof, K. Lenti and K. Maghami et al., 2013. Liposomes for topical use: A physico-chemical comparison of vesicles prepared from egg or soy lecithin. Sci. Pharm. (In Press). 10.3797/scipharm.1305-11.
    CrossRef  |  PubMed  |  Direct Link  |  

  5. Yu, J.C.C., S. Martin, J. Nasr, K. Stafford, D.E. Thompson and I. Petrikovics, 2012. LC-MS/MS analysis of 2-aminothiazoline-4-carboxylic acid as a forensic biomarker for cyanide poisoning. J. World Methodol., 2: 33-41.
    Direct Link  |  

  6. Szilasi, M., M. Budai, L. Budai and I. Petrikovics, 2012. Nanoencapsulated and microencapsulated enzymes in drug antidotal therapy. Toxicol. Ind. Health, 28: 522-531.
    CrossRef  |  PubMed  |  Direct Link  |  

  7. Petrikovics, I., M. Wales, M. Budai, J.C.C. Jorn and M. Szilasi, 2012. Nano-intercalated organophosphorus-hydrolyzing enzymes in organophosphorus antagonism. AAPS PharmSciTech., 13: 112-117.
    CrossRef  |  PubMed  |  Direct Link  |  

  8. Petrikovics, I., J.C.C. Yu, D.E. Thompson, P. Jayanna and B.A. Logue et al., 2012. Plasma persistence of 2-aminothiazoline-4-carboxylic acid in rat system determined by liquid chromatography tandem spectrometry. J. Chromatography B, 891-892: 81-84.
    CrossRef  |  PubMed  |  Direct Link  |  

  9. Manage, B.W.M. and I. Petrikovics, 2012. Confidence limit calculation for antidotal potency ratio derived from lethal dose 50. J. World Methodol., 3: 7-10.
    Direct Link  |  

  10. Bhandari, R.K., R.P. Oda, S.I. Youso, I. Petrikovics, V.S. Bebarta, G.A. Rockwoodand B.A. Logue, 2012. Simultaneous determination of cyanide and thiocyanate in plasma by chemical ionization gas chromatography mass-spectrometry (CI-GC-MS). Analyt. Bioanalytical Chem., 404: 2287-2294.
    CrossRef  |  PubMed  |  Direct Link  |  

  11. Petrikovics, I., P. Jayanna, J. Childress, M. Budai, S. Martin, G. Kuzmitcheva and G.A. Rockwood, 2011. Optimization of liposomal lipid composition for a new, reactive sulfur donor, and in vivo efficacy studies on mice to antagonize cyanide intoxication. J. Drug Delivery, (In Press). 10.1155/2011/928626.
    CrossRef  |  PubMed  |  Direct Link  |  

  12. Petrikovics, I., D.E. Thompson, G.A. Rockwood and B.A. Logue et al., 2011. Organ-Distribution of the metabolite 2-aminothiazoline-4-carboxylic acid in a rat model following cyanide exposure. Biomarkers, 16: 686-690.
    CrossRef  |  PubMed  |  Direct Link  |  

  13. Petrikovics, I., S.I. Baskin, K.M. Beigel, B.J. Schapiro and G.A. Rockwood et al., 2010. Nano-intercalated rhodanese in cyanide antagonism. Nanotoxicology, 4: 247-254.
    CrossRef  |  PubMed  |  Direct Link  |  

  14. Jackson, R., I. Petrikovics, E.P. Lai and J.C.C., Yu, 2010. Molecularly imprinted polymer stir bar sorption extraction and electrospray ionization tandem mass spectrometry for determination of 2-aminothiazoline-4-carboxylic acid as a marker for cyanide exposure in forensic urine analysis. Analyt. Methods, 2: 552-557.
    CrossRef  |  Direct Link  |  

  15. Petrikovics, I., M. Budai, S.I. Baskin, G.A. Rockwood and J. Childress et al., 2009. Characterization of liposomal vesicles encapsulating rhodanese for cyanide antagonism. Drug Delivery, 16: 312-319.
    CrossRef  |  PubMed  |  Direct Link  |  

  16. Budai, M., P. Chapela, L. Budai, M.E. Wales and I. Petrikovics et al., 2009. Liposomal oxytetracycline and doxycycline: studies on enhancement of encapsulation efficiency. Drug Discov. Ther., 3: 13-17.
    PubMed  |  Direct Link  |  

  17. Budai, M. P. Chapela, P. Grof, I. Klebovich and A. Zimmer et al., 2009. Physicochemical characterization of stealth liposomes encapsulating an organophosphate hydrolyzing enzyme. J. Liposome Res., 2: 163-168.
    CrossRef  |  PubMed  |  Direct Link  |  

  18. Petrikovics, I., M.E. Wales, J.C. Jaszberenyi, M. Budai and S.I. Baskin et al., 2007. Enzyme-based intravascular defense against organophosphorus neurotoxins: Synergism of dendritic-enzyme complexes with 2-PAM and atropine. Nanotoxicology, 1: 85-92.
    CrossRef  |  Direct Link  |  

  19. Baskin, S.I., I. Petrikovics, G.E. Platoff, G.A. Rockwood and B.A. Logue, 2006. Spectrophotometric analysis of the cyanide metabolite 2-aminothiazoline-4-carboxylic acid (ATCA). Toxicol. Methods Mechanism, 16: 339-345.
    CrossRef  |  PubMed  |  Direct Link  |  

  20. Logue, B.A., N.P. Kirschten, I. Petrikovics, M.A. Moser, G.A. Rockwood and S.I. Baskin, 2005. Determination of the cyanide metabolite 2-aminothiazoline-4-carboxylic acid in urine and plasma by gas chromatography-mass spectrometry. J. Chromatography, 819: 237-244.
    CrossRef  |  PubMed  |  Direct Link  |  

  21. Arsenault, W.G., D.M. Boothe, S.G. Gordon, M.W. Miller, J.R. Chalkley and I. Petrikovics, 2005. Pharmacokinetics of carvedilol after intravenous and oral administration in conscious healthy dogs. Am. J. Vet. Res., 66: 2172-2176.
    CrossRef  |  PubMed  |  Direct Link  |  

  22. Petrikovics, I., D. Papahadjapoulos, K. Hong, T.C. Cheng and S.I. Baskin et al., 2004. Comparing therapeutic and prophylactic protection against the lethal effects of paraoxon. Toxicol. Sci., 77: 258-262.
    CrossRef  |  PubMed  |  Direct Link  |  

  23. Cheng, T.C., S.P. Harvey, J.J. De Frank, I. Petrikovics and V.P. Rastogi, 2004. Bacterial Ezymes- Potential Applications for Personnel/Casualty Decontamination Against G,V and H,D Chemical Agents. In: Pharmacological Perspectives of Toxic Chemicals and Their Antidotes, Flora, S.J.S., J.A. Romano S.I. Baskin and K. Sekhar (Eds.). Narosa Publishing House, New Delhi, India, pp: 87-95.

  24. Baskin, S.I., I. Petrikovics, J.S. Kurche, J.D. Nicholson, B.A. Logue, B.I. Maliner and G.A. Rockwood, 2004. Insights on Cyanide Toxicity and Methods of Treatment. In: Pharmacological Perspectives of Toxic Chemicals and their Antidotes, Flora, S.J.S., J.A. Romano, S.I. Baskin and K. Sekhar (Eds.). Narosa Publishing House, New Delhi, India, pp: 105-146.

  25. Petrikovics, I., T.C. Cheng, D. Papahadjapoulos, K. Hong and R. Yin et al., 2000. Long Circulating liposomes encapsulating organophosphorus acid anhydrolase in diisopropylfluorophosphate antagonism. Toxicol. Sci., 57: 16-21.
    CrossRef  |  PubMed  |  Direct Link  |  

  26. Petrikovics, I., K. Hong, D. Papahadjapoulos, P. Yuzapavik and et al., 2000. In vitro studies on sterically stabilized liposomes (sl) as enzyme carriers in organophosphorus (OP) antagonism. Drug Delivery, 7: 83-89.
    CrossRef  |  PubMed  |  Direct Link  |  

  27. Petrikovics, I., K. Hong, G. Omburo, Q. Hu and L. Pei et al., 1999. Antagonism of paraoxon intoxication by recombinant phosphotriesterase encapsulated within sterically stabilized liposomes. Toxicol. Applied Pharmacol., 156: 56-63.
    CrossRef  |  PubMed  |  Direct Link  |  

  28. Way, J.L., L. Pei, I. Petrikovics, D.W. McGuinn and C. Tamulinas et al., 1996. Organophosphorus Antagonism by Resealed Erythrocytes Containing Recombinant Paraoxonase. In: Erythrocytes as Drug Carriers in Medicine, Sprandel, U. and J.L. Way (Eds.). Plenum Press, New York, pp: 89-92.
    CrossRef  |  Direct Link  |  

  29. Petrikovics, I., E.P. Cannon, W.D. McGuinn, L. Pei and J.L. Way, 1995. Cyanide antagonism with organic thiosulfonates and carrier red blood cells containing rhodanese. Fundamental Applied Toxicol., 24: 1-8.

  30. Pei, L., I. Petrikovics and J.L. Way, 1995. Antagonism of the lethal effect of paraoxon by carrier erythrocytes containing organophosphorous acid anhydrase. Fundamental Applied Toxicol., 28: 209-214.

  31. Petrikovics, I., W.D. McGuinn, E.P. Cannon, L. Pei and J.L. Way, 1994. Encapsulation of rhodanese and organic thiosulfonates by mouse erythrocytes. Fundamental Applied Toxicol., 23: 70-75.
    CrossRef  |  PubMed  |  Direct Link  |  

  32. Pei, L., W.D. McGuinn, G. Omburo, A.H. Zitzer, I. Petrikovics and J.L. Way, 1994. Spectrophotometric determination of paraoxonase within mouse carrier red blood cells. Biochem. Applied Biotechnol., 23: 35-41.
    PubMed  |  

  33. Pei, L., G. Omburo, W.D. McGuinn, I. Petrikovics and K. Dave et al., 1994. Encapsulation of phosphotriesterase within murine erythrocytes. Toxicol. Applied Pharmacol., 124: 296-301.
    CrossRef  |  PubMed  |  Direct Link  |  

  34. McGuinn, W.D., L. Baxter, L. Pei, I. Petrikovics, E.P. Cannon and J.L. Way, 1994. Antagonism of the lethal effects of cyanide by a synthetic water-soluble cobalt(III) porphyrin compound. Fundamental Applied Toxicol., 23: 76-80.
    CrossRef  |  PubMed  |  Direct Link  |  

  35. Cannon, E.P., P. Leung, A.H. Zitzer, I. Petrikovics, J. Deloach and J.L. Way, 1994. Antagonism of cyanide intoxication with murine carrier erythrocytes containing bovine rhodanese and sodium thiosulfate. J. Toxicol. Environ. Health, 41: 267-274.
    CrossRef  |  PubMed  |  Direct Link  |  

  36. Petrikovics, I., W.D. McGuinn, E.P. Cannon, L. Pei, L. Pu, A. Chen and J.L. Way, 1993. Carrier Red Blood Cells in Cyanide Antagonism. In: Resealed Carrier Red Blood Cells as Bioreactors, DeLoach, J.R. and J.L. Way (Eds.). Vol. 92, Pergamon Press, Oxford, UK., pp: 125-129.

  37. Pei, L., W.D. McGuinn, I. Petrikovics, L. Pu and J.L. Way, 1993. Hydrolysis of Paraoxon by Paraoxonase Encapsulated within Carrier Murine Erythrocytes. In: Resealed Carrier Red Blood Cells as Bioreactors, DeLoach, J.R. and J.L. Way (Eds.). Vol. 92, Pergamon Press, Oxford, UK., pp: 131-135.

  38. Pei, L., W.D. McGuinn, I. Petrikovics, E.P. Cannon and J.L. Way, 1993. Determination of organophorous acid anhydrase in blood. Toxicol. Methods, 3: 261-267.
    CrossRef  |  Direct Link  |  

  39. McGuinn, W.D., E.P. Cannon, C.K. Chui, L. Pei, I. Petrikovics and J.L. Way, 1993. The encapsulation of squid diisopropylphosphorofluoridate-hydrolyzing enzyme within mouse erythrocytes. Fundam. Applied Toxicol., 21: 38-43.
    CrossRef  |  PubMed  |  Direct Link  |  

  40. Way, J.L., L. Baxter, W.D. McGuinn, H.A. Zitzer and I. Petrikovics, 1992. Occupational Hazards and Ocular Toxicity. In: Ophthalmic Toxicology, Chiou, G.C.Y. (Ed.). Raven Press Ltd., New York, pp: 291-305.

  41. Way, J.L., E.P. Cannon, P. Leung, H.A. Zitzer, L. Pei and I. Petrikovics, 1992. Antagonism of the Lethal Effects of Cyanide with Resealed Erythrocytes Containing Rhodanese and Thiosulfate. In: The Use of Resealed Erythrocytes as Carriers and Bioreactors, Magnani, M. and J.R. Deloach (Eds.). Plenum Press, New York, pp: 159-163.
    CrossRef  |  PubMed  |  Direct Link  |  

  42. Cannon, E.P., A.H. Zitzer, D.W. McGuinn, I. Petrikovics, P. Leung and J.L. Way, 1992. Antagonism of the lethal effects of cyanide with rhodanese containing murine carrier erythrocytes. Proc. West. Pharmacol. Soc., 35: 187-190.
    PubMed  |  

  43. Petrikovics, I., J.C. Jaszberenyi, F. Hernadi, F. Sztaricskai, R. Bognar, G. Batta and L. Benesch, 1991. Synthesis and bioactivity of β-lactamase inhibitory iodopenicillanic acid derivatives. Acta Chim. Acad. Sci. Hung., 128: 41-52.

  44. Leung, P., E.P. Cannon, I. Petrikovics and J.L. Way, 1991. In vivo studies on rhodanese encapsulation in mouse carrier erythrocytes. Toxicol. Applied Pharmacol., 110: 268-274.
    CrossRef  |  PubMed  |  Direct Link  |  

  45. Jaszberenyi, J.C., J. Pitlik, K. Kollar, I. Petrikovics, K. Erdodine-Kover and G. Batta, 1989. Synthesis and 1,3-dipolar cycloadditions of 2-methylenecephalosporins. Acta Chim. Acad. Sci. Hung., 126: 81-97.

  46. Hernadi, F., I. Petrikovics, J.C. Jaszberenyi and M. Frommer-Filep, 1989. Inhibition of β-lactamases by halopenicillanic acid derivatives. Int. J. Exp. Clin. Chemotheraphy, 2: 209-214.

  47. Hernadi, F., J.C. Jaszberenyi and I. Petrikovics, 1986. Complex analysis methods for study of β-lactamase inhibitors. Am. Clin. Prod. Rev., 5: 18-27.

  48. Kiss, L., Z. Gal, B.L. Tothmartinez and I. Petrikovics, 1983. Use of chromatofocusing for separation of β-lactamases: II. β-Lactamase of a characterized Pseudomonas aeruginosa strain. J. Chromatography A, 262: 379-384.
    CrossRef  |  PubMed  |  Direct Link  |  

  49. Jaszberenyi, J.C., I. Petrikovics, E.T. Gunda and S. Hosztafi, 1982. On the mannich-reaction of cephalosporin sulphoxides and sulphones. Acta Chim. Acad. Sci. Hung., 110: 81-84.

  50. Jaszberenyi, J.C., Z. Dinya, M. Punyiczki, E.K. Kover, J. Schag and I. Petrikovics, 1981. Synthesis and β-lactamase inhibitory properties of derivatives of β-lactam antibiotics. Biol. Nat. Prod., 3: 78-81.