Dr. Halyna P. Kopylchuk
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Dr. Halyna P. Kopylchuk

Professor
Yuriy Fedkovych Chernivtsi National University, Ukraine

Highest Degree
Ph.D. in Biochemistry from Yuriy Fedkovych Chernivtsi National University, Ukraine

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Area of Interest:

Molecular Sciences
100%
Medical Biology
62%
Biotechnology
90%
Biochemistry
75%
Metabolism
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Voloshchuk, O.M., G.P. Kopylchuk and K.V. Larionova, 2018. Peculiarities of tyrosine metabol-ism in the rat liver under the condition of protein deficiency. Biol. Syst., 10: 3-7.
    CrossRef  |  
  2. Voloshchuk O.M., G.P. Kopylchuk and Y.I. Mishyna, 2018. Аctivity of the mitochondrial isoenzymes of endogenous aldehydes catabolism under the conditions of acetaminophen-induced hepatitis. Ukr. Biochem. J., 90: 42-47.
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  3. Voloshchuk, O.N. and G.P. Kopylchuk, 2017. Cellular immunity state of protein-deficient rats with the toxic liver injury. J. Stress Physiol. Biochem., 13: 19-25.
  4. Kopylchuk, H.P., I.M. Nykolaichuk and O.M. Zhuretska, 2017. Rat liver arginase system under acetaminophen-induced toxic injury and protein deprivation. Ukr. Biochem. J., 89: 92-98.
    CrossRef  |  
  5. Voloshchuk, O.N. and G.P. Kopylchuk, 2016. Bandura SV activity of the energy supply marker enzymes of blood leycocytes' mitochondria under the conditions of alimentary deprivation of protein. Problems Biol. Med. Farmaceutical Chem., 1: 33-37.
  6. Voloshchuk, O.N. and G.P. Kopylchuk, 2016. Activity of liver mitochondrial NAD+-dependent dehydrogenases of the krebs cycle in rats with acetaminophen-induced hepatitis developed under conditions of alimentary protein deficiency. Biomeditsinskaia Khimiia, 62: 169-172.
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  7. Voloshchuk, O.N. and G.P. Kopylchuk, 2016. Activity of liver mitochondrial Krebs cy-cle NAD+-dependent dehydrogenases in rats with hepatitis induced by acetaminophen under conditions of alimentary protein deficiency. Biochem. (Moscow) Supplement Se-ries B: Biomed. Chem., 10: 283-286.
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  8. Kopylchuk, G.P., 2016. Features of the desulfurization pathway of sulfur containing amino acids in rat hepatocytes under the conditions of protein deficiency and toxic injury. Ukr. Biochem. J., 88: 68-68.
  9. Kopylchuk, G.P. and O.M. Voloshchuk, 2016. Peculiarities of the free radical processes in rat liver mitochondria under toxic hepatitis on the background of alimentary protein deficiency. Ukrainian Biochem. J., 88: 66-72.
  10. Voloshchuk, O.N., G.P. Kopylchuk and О.D. Badyak, 2015. Activity of the malate-aspartate shuttle mitochondrial enzymes in rats under the conditions of alimentary deficiency of protein. Zhurnal Fundamental'noj Mediciny I Biologii, 2: 32-36.
  11. Voloshchuk, O.N. and G.P. Kopylchuk, 2015. The ratio of ubiquinone redox forms in the liver mitochondria under toxic hepatitis induced on the background of alimentary protein deficiency. Problems Nutr., 84: 84-89.
  12. Voloshchuk, O.N. and G.P. Kopylchuk, 2015. The peculiarities of the structural and functional state of the cytochrome component of the liver mitochondrial respiratory chain under conditions of acetaminophen-induced hepatitis on the background of alimentary protein deprivation. Biophysics, 60: 420-424.
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  13. Voloshchuk, O.N. and G.P. Kopylchuk, 2015. Structural-functional state of the cytochromic part of liver mitochondria respiratory chain under the conditions of alimentary deprivation of protein. Problems Biol. Med. Farm. Chem., 1: 43-46.
  14. Voloshchuk, O.N. and G.P. Kopylchuk, 2015. Activity of the respiratory chain enzymes of blood leucocytes’ mitochondria under the conditions of toxic hepatitis induced against the background alimentary deprivation of protein. J. Stress Physiol. Biochem., 11: 51-57.
  15. Kopylchuk, G.P., I.M. Buchkovska and R.O. Nikolayev, 2015. Indicators of endogenous intoxication in rats with toxic hepatitis under the conditions of alimentary deficiency of protein. Ukr. Biochem. J., 87: 107-107.
  16. Kopylchuk, G.P. and O.N. Voloshchuk, 2015. NADH: Ubiquinone reductase and succinate dehydrogenase activity in the liver of rats with acetaminophen-induced toxic hepatitis on the background of alimentary protein deficiency. Ukr. Biochem. J., 87: 20-25.
  17. Kopylchuk, G.P. and O.N. Voloshchuk, 2015. Modeling of the acetaminophen-induced disturbances of the bile producing liver function under the conditions of alimentary deprivation of protein. Biomedicine, 2: 30-36.
  18. Kopylchuk, G.P. and I.M. Buchkovskaia, 2014. Activity of L-arginine metabolism enzymes in the rat liver subcellular fractions under the conditions of alimentary protein deprivation. Problems Nutr., 83: 15-21.
  19. Kopyl'chuk, G.P. and I.M. Buchkovska, 2014. State of the glutathione system in rat liver cells under the conditions of low-protein ration and acute hepatotoxicity. Ukr. Biochem. J., 86: 165-166.
  20. Kopyl'chuk, G.P. and T.G. Kadaiskaia, 2013. State of the energy-supply system of the liver mitochondria under the conditions of alimentary deficiency of protein. Voprosy Pitaniia, 83: 12-16.
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  21. Marchenko, M.M., H.P. Kopyl'chuk, I.O. Shmarakov and I.M. Buchkovs'ka, 2011. Ac-tivity of enzymatic detoxification systems in the mice liver under conditions of different retinoid provision. Ukrains' kyi Biokhimichnyi Zhurnal, 84: 42-47.
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  22. Kopyl'chuk, G.P., I.A. Shmarakov, I.M. Buchkovskaia, M.M. Marchenko and V.S. Blener, 2011. Cytochrome p450 system components and nitric oxide synthase activity in mouse liver under conditions of retinoid stores absence. Biomeditsinskaia Khimiia, 58: 549-555.
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  23. Marchenko, M.M., G.P. Kopylchuk, I.O. Shmarakov and L.V. Blynda, 2009. Genotoxicity estimation of tumor growth in organisms preliminary irradiated at low doses. Biopolymers Cell, 25: 234-239.
    CrossRef  |  
  24. Marchenko, M.M., G.P. Kopyl'chuk and O.V. Ketsa, 2009. Low doses of X-ray irradia-tion influence the liver detoxication system in rats with transplanted Guerin's carcinoma. Biochemistry (Moscow) Suppl. Ser. B: Biomed. Chem., 3: 377-381.
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  25. Marchenko, M.M., H.P. Kopyl'chuk and O.M. Voloshchuk, 2007. Effect of low doses of ionizing radiaton on the fractional content of mitochondrial proteins and mtDNA in Guerin's carcinoma. Ukrains'kyi Biokhimichnyi Zhurnal, 80: 114-119.
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  26. Marchenko, M.M., G.P. Kopyl'chuk and O.M. Voloshchuk, 2007. Oxidative destruction of mitochondrial translation products after fractionated irradiation of rats with tumor. Bull. Exp. Biol. Med., 144: 520-522.
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  27. Kopylchuk, H.P., I.O. Shmarakov and M.M. Marchenko, 2007. A possible mechanism of antitumor activity of 5 (5’, 6’ benZocoumAroyl 3’) methylaminouracil in vivo. Exp. Oncol., 29: 320-322.
  28. Kopyl'chuk, H.P., M.M. Marchenko and H.V. Iakovyshyn, 2007. Histone specific pro-teinase and DNase activity of spleen lymphocyte nuclei during oncogenesis and under the effect of hydrobromide-5-(5', 6'benzocoumaroyl-3')-methylaminouracil. Ukrains' kyi Biokhimichnyi Zhurnal, 80: 40-45.
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  29. Shmarakov, I., G. Kopylchuk and M. Marchenko, 2006. Molecular stability of Huerin's carcinoma nuclear DNA during oncogenesis. FEBS J., 273: 187-187.
  30. Marchenko, M.M., G.P. Kopyl'chuk, I.A. Shmarakov, O.V. Ketsa and V.N. Kushnir, 2006. Synthesis and antitumor activity of 5-(5′, 6'-benzocoumaro-3'-yl) methylaminouracil hydrobromide and its liposomal medicinal form. Pharm. Chem. J., 40: 296-297.
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  31. Marchenko, M.M., G.P. Kopyl'chuk and I.A. Shmarakov, 2005. Effect of preliminary ir-radiation on DNA-ase activity and DNA fragmentation degree in the nuclei of Guerin's carcinoma cells. Voprosy Onkologii, 52: 63-65.
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  32. Marchenko, M.M., G.P. Kopyl'chuk and I.O. Shmarakov, 2004. Dnase activity and chromatin fragmentation in cell nuclei in the process of tumor growth. Biopolymers Cell, 20: 511-514.
    CrossRef  |  
  33. Kopyl'chuk, G.P., I.A. Shmarakov and M.M. Marchenko, 2004. Effect of tumor growth and preliminary irradiation on the state of DNA degradation processes in the liver cell nuclei. Radiatsionnaia Biologiia Radioecologiia, 45: 397-404.
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  34. Marchenko, M.M., H.P. Kopyl'chuk and I.O. Shmarakov, 2003. Extracellular DNA fragments and DNAse activity in blood serum of rats with transplantated Guerin's carci-noma after multiple exposures to low doses of X-irradiation. Ukrains' Kyi Biokhimichnyi Zhurnal, 76: 131-135.
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  35. Marchenko, M.M., G.P. Kopilchuk and O.V. Grigorjeva, 2002. Histone hydrolysis in in-sulated nuclei of carcinoma and in liver cells of rats with Keren's carcinoma at tumor growth. Biopolymers Cell, 18: 406-410.
    CrossRef  |  
  36. Kopylchuk, G.P., L.V. Khuda and M.M. Marchenko, 2002. Proteins oxidative modifica-tion of liver and HEREN'S carcinoma chromatin in the rats. Ukrainskii Biokhimicheskii Zhurnal, 74: 111-114.
  37. Marchenko, M.M., G.P. Kopyl'chuk and E.V. Grigor'eva, 2001. Influence of small doses of fractionated X-ray radiation on the activity of histone-specific proteases and the con-tent of malonic dialdehyde in chromatin of the cells of rat liver. Radiatsionnaia Biologiia Radioecologiia, 42: 488-491.
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  38. Marchenko, M.M., H.P. Kopyl'chuk and O.V. Hrygor'ieva, 1999. Activity of cytoplas-mic proteinases from rat liver in Heren's carcinoma during tumor growth and treatment with medicinal herbs. Ukrains' kyi Biokhimichnyi Zhurnal, 72: 91-94.
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