Hi, I am Dejan Nikolic, My LiveDNA is 381.5959
 
   
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Dr. Dejan Nikolic
 
Highest Degree: Ph.D. in Medicinal Chemistry from University of Illinois, USA
 
Institute: University of Illinois, USA
 
Area of Interest: Biomedical Sciences
  •   Natural Products
  •   Drug Discovery
  •   Drug Developing
  •   Mass Spectrometry
 
URL: http://livedna.org/381.5959
 
My SELECTED Publications
1:   Bolca, S., J. Li, D. Nikolic N. Roche and P. Blondeel et al., 2010. Disposition of hop prenylflavonoids in normal breast tissue. Mol. Nutr. Food. Res., 54: S284-S294.
PubMed  |  
2:   Booth, N.L., C.R. Overk, P. Yao, J.E. Burdette and D. Nikolic et al., 2006. The chemical and biological profile of a red clover (Trifolium pretense) phase II clinical extract., J. Altern. Complement. Med., 12: 133-139.
PubMed  |  
3:   Booth, N.L., D. Nikolic, S. Geller, R.B. van Breemen and S.E. Geller et al., 2004. Confusion regarding anticoagulant coumarins in dietary supplements. Clin. Pharmacol. Ther., 76: 511-516.
PubMed  |  
4:   Cao, H., R. Yu, Y. Tao, D. Nikolic and R.B. van Breemen, 2011. Measurement of cyclooxygenase inhibition using liquid chromatography-tandem mass spectrometry. J. Pharmaceut. Biomed. Anal., 54: 230-235.
CrossRef  |  PubMed  |  Direct Link  |  
5:   Chadwick, L.R., D. Nikolic, J.E. Burdette, C.R. Overk and J.L. Bolton et al., 2004. Estrogens and congeners from spent hops. J. Nat. Prod., 67: 2024-2032.
PubMed  |  
6:   Chen, S.N., A. Turner, B. Jaki, D. Nikolic, R.B. van Breemen, B. Friesen and G.F. Pauli, 2008. An experimental implementation of chemical subtraction. J. Pharm. Biomed. Anal., 46: 692-698.
CrossRef  |  PubMed  |  
7:   Chen, S.N., B.J. Friesen, D. Webster, D. Nikolic and R.B. van Breemen et al., 2011. Chemical components from the fruits of Vitex agnus-castus. Fitoterapia 82: 528-533.
8:   Chen, S.N., D. Lankin, D. Nikolic, D.S. Fabricant and Z.Z. Lu et al., 2007. Chlorination diversifies Cimicifuga racemosa tripetrpene glycosides. J. Nat. Prod., 70: 1016-1023.
PubMed  |  
9:   Deng, S., S.N. Chen, J. Lu, Z.J. Wang and D. Nikolic et al., 2006. GABAergic phthalide dimers from Angelica sinensis (Oliv.) diels. Phytochem. Anal., 17: 398-405.
PubMed  |  
10:   Deng, S., S.N. Chen, P. Yao, D. Nikolic and R.B. van Breemen et al., 2006. Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis. J. Nat. Prod., 69: 536-541.
PubMed  |  
11:   Dong, S.H., D. Nikolic, C. Simmler, Q. Feng and R.B. van Breemen et al., 2012. Diarylheptanoids from Dioscorea villosa (Wild Yam). J. Nat. Prod., 75: 2168-2177.
CrossRef  |  Direct Link  |  
12:   Fabricant, D., D. Nikolic, D. Lankin, S.N. Chen and B. Jaki et al., 2005. Cimipronidine: A cyclic guanidine alkaloid from Cimicifuga racemosa (L.) nutt. J. Nat. Prod., 68: 1266-1270.
13:   Geller, S.E., S. Banuvar, L.P. Shulman, G. Epstein and Y. Zhou et al., 2009. Efficacy and safety of black cohosh and red clover for the management of vasomotor symptoms: A randomized controlled trial. Menopause, 16: 1156-1166.
PubMed  |  
14:   Godecke, T., D. Lankin, D. Nikolic, S.N. Chen, R. van Breemen, N. Farnsworth and G.F. Pauli, 2009. Guanidine alkaloids and Pictet-Spengler adducts from black cohosh. J. Nat. Prod., 72: 433-437.
PubMed  |  
15:   Godecke, T., D. Nikolic, D. Lankin, S.N. Chen and S.L. Powell et al., 2009. Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts. Phytochem. Anal., 20: 120-133.
PubMed  |  
16:   Godecke, T., P. Yao, J. Napolitano, D. Nikolic and B.M. Dietz et al., 2012. Integrated standardization concept for Angelica botanicals using quantitative NMR Fitoterapia, 83: 18-32.
CrossRef  |  PubMed  |  
17:   Guo, J., D. Liu, D. Nikolic, D. Zhu, J.M. Pezzuto and R.B. van Breemen, 2008. In vitro metabolism of isoliquiritigenin by human liver microsomes. Drug Metab. Dispos., 36: 461-468.
PubMed  |  
18:   Guo, J., D. Nikolic, L.R. Chadwick, G.F. Pauli and R.B. van Breemen, 2006. Identification of human hepatic cytochromes P450 isoforms involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.). Drug Metab. Dispos., 34: 1152-1159.
19:   Hamm, M.L., D. Nikolic, R.B. van Breemen and J.A. Piccirilli, 2000. Unconventional origin of metal ion rescue in the hammerhead ribozyme reaction: Mn2+ -assisted redox conversion of 2'-mercaptocytidine to cytidine. J. Am. Chem. Soc., 122: 12069-12078.
Direct Link  |  
20:   Hu, C., D. Nikolic, A.L. Eggler, A.D. Mesecar and R.B. van Breemen, 2012. Screening for natural chemoprevention agents that modify human Keap1. Anal. Biochem., 421: 108-114.
PubMed  |  
21:   Huang, Y., D. Nikolic, S. Pendland, B. Doyle, T.D. Locklear and G.B. Mahady, 2009. Effects of cranberry extracts on ursolic acid derivatives on P-fimbriated Escherichia coli, COX-2 activity, pro-inflammatory cytokine release and the NF-κβ transcriptional response in vitro. Pharm. Biol., 47: 18-25.
PubMed  |  
22:   Inui, T., Y. Wang, D. Nikolic, S. Franzblau, D. Smith and G.F. Pauli, 2010. Sesquiterpenes from Oplopanax horridus. J. Nat. Prod., 73: 563-567.
PubMed  |  
23:   Johnson, B., D. Nikolic and R.B. van Breemen, 2002. Applications of pulsed ultrafiltration mass spectrometry. Mass Spectrom. Rev., 21: 76-86.
PubMed  |  
24:   Kabirov, K.K., I.M. Kapetanovic, D.M. Benbrook, N. Dinger and I. Mankovskaya et al., 2013. Oral toxicity and pharmacokinetic studies of SHetA2, a new chemopreventive agent, in rats and dogs. Drug. Chem. Toxicol., 36: 284-295.
PubMed  |  
25:   Koloumbos, V.N., D.F. Tsipi, A.E. Hiskia, D. Nikolic and R.B. van Breemen, 2003. Identification of photocatalytic degradation products of diazinon in TiO2 aqueous suspensions using GC/MS/MS and LC-MS with quadrupole time-of-flight mass spectrometry. J. Am. Soc. Mass Spectrom., 14: 803-817.
PubMed  |  
26:   Li, J., T. Godecke, S.N. Chen, A. Imai and D.C. Lankin et al., 2011. In vitro metabolic interactions between black cohosh (Cimicifuga racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4. Xenobiotica, 41: 1021-1030.
PubMed  |  
27:   Li, Y., J. Yao, M. Chang, D. Nikolic and L. Yu et al., 2004. Equine catechol estrogen 4-hydroxyequilenin is a more potent inhibitor of the variant form of catechol-O-methyltransferase. Chem. Res. Toxicol., 17: 512-520.
PubMed  |  
28:   Li, Y., S. Grubjesic, D. Nikolic, J.W. Kosmeder, R.M. Moriarty, J.M. Pezzuto and R.B. van Breemen, 2004. In vitro assessment of intestinal permeability and hepatic metabolism of 4'-bromoflavone, a promising cancer chemopreventive agent. Xenobiotica, 34: 535-547.
PubMed  |  
29:   Liu, J., J. Burdette, Y. Sun, S. Deng and S.M. Schlecht et al., 2004. Isolation of linoleic acid as an estrogen-like compound from the fruits of Vitex agnus-castus L. (chaste berry). Phytomedicine, 11: 18-23.
PubMed  |  
30:   Lu, X., D. Nikolic, D. Mitchell, R.B. van Breemen, J.A. Mersfelder, R. Hille and R.B. Silverman, 2003. A mechanism for substrate-induced formation of 6-hydroxyflavin mononucleotide catalyzed by C30A trimethylamine dehydrogenase. Bioorg. Med. Chem. Lett., 13: 4129-4132.
PubMed  |  
31:   Mitchell, D.J. D. Nikolic, M.H. Jang, R.B. van Breemen, R. Hille and R.B. Silverman, 2001. Inactivation of C30A trimethylamine dehydrogenase by N-Cyclopropyl-a-methylbenzylamine, 1-phenylcyclopropylamine and phenylhydrazine. Biochemistry, 40: 8523-8530.
PubMed  |  
32:   Mitchell, D.J., D. Nikolic, E. Rivera, S.O. Sablin, R.B. van Breemen, T.P. Singer and R.B. Silverman, 2001. Spectrometric evidence for the flavin-1-phenylcyclopropylamine inactivator adduct with monoamine oxidase N. Biochemistry, 40: 5447-5456.
PubMed  |  
33:   Mitchell, D.J., D. Nikolic, R.B. van Breemen and R.B. Silverman, 2001. Inactivation of monoamine oxidase B by 1-phenylcyclopropylamine: Mass spectral evidence for the flavin adduct. Bioorg. Med. Chem. Lett., 11: 1757-1760.
PubMed  |  
34:   Nikolic, D. and R.B. van Breemen, 2013. Analytical methods for quantitation of prenylated flavonoids from hops. Curr. Anal. Chem., 9: 71-85.
PubMed  |  
35:   Nikolic, D. and R.B. van Breemen, 2001. DNA oxidation induced by cyclooxygenase-2. Chem. Res. Toxicol., 14: 351-354.
CrossRef  |  PubMed  |  Direct Link  |  
36:   Nikolic, D. and R.B. van Breemen, 2004. New metabolic pathways for flavanones catalyzed by rat liver microsomes. Drug Metab. Dispos., 32: 387-397.
PubMed  |  
37:   Nikolic, D., 2010. A liquid chromatography-mass spectrometric assay for measuring activity of human 8-oxoguanine-DNA-glycosylase. Anal. Biochem., 396: 275-279.
PubMed  |  
38:   Nikolic, D., S.H. Goudarzi, D.G. Corley, S. Gafner, J.M. Pezzuto and R.B. van Breemen, 2000. Evaluation of cyclooxygenase-2 inhibitors using pulsed ultrafiltration-mass spectrometry. Anal. Chem., 72: 3853-3859.
PubMed  |  
39:   Nikolic, D., T. Goedecke, S.N. Chen, J. White, D. Lankin, G.F. Pauli and R.B. van Breemen, 2012. Mass spectrometric dereplication of nitrogen-containing constituents of black cohosh (Cimicifuga racemosa L.). Fitoterapia, 83: 441-460.
PubMed  |  
40:   Nikolic, D., Y. Li, L.R. Chadwick and R.B. van Breemen, 2006. Intestinal permeability and hepatic metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus L.). Pharm. Res., 23: 864-872.
41:   Nikolic, D., Y. Li, L.R. Chadwick, G.F. Pauli and R.B. van Breemen, 2005. Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes. J. Mass Spectrom., 40: 289-299.
PubMed  |  
42:   Nikolic, D., Y. Li, L.R. Chadwick, S. Grubjesic, P. Schwab and R.B. van Breemen, 2004. Metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus L.) by human liver microsomes. Drug Metab. Dispos., 32: 272-279.
43:   Overk, C.R., P. Yao, L.R. Chadwick, D. Nikolic and Y. Sun et al., 2005. Comparison of estrogenic activities of pure compounds found in hops and red clover. J. Agric. Food Chem., 53: 6246-6253.
44:   Pang, Y., D. Nikolic, D. Zhu, L.R. Chadwick, G.F. Pauli, N.R. Farnsworth and R.B. van Breemen, 2007. Binding of the hop (Humulus lupulus L.) chalcone xanthohumol to cytosolic proteins in Caco-2 intestinal epithelial cells. Mol. Nutr. Food. Res., 51: 872-879.
CrossRef  |  PubMed  |  
45:   Powell, S.L., T. Godecke, D. Nikolic, S.N. Chen and B. Dietz et al., 2008. In vitro serotonergic activity of black cohosh (Cimicifuga racemosa) and identification of a potential active constituent, Nω-methylserotonin. J. Agric. Food Chem., 56: 11718-11726.
PubMed  |  
46:   Stanojkovic, T., B. Kolundzija, A. Ciric, M. Sokovic, D. Nikolic and T. Kundakovic, 2013. Cytotoxicity and antimicrobial activity of Satureja kitabelli Wirzb. Ex Heuff (Lamiaceae). Digest J. Nanomet. Nanostruct., 8: 845-854.
47:   Su, B.N., E.J. Park, D. Nikolic, B.D. Santarsiero and A.D. Mesecar et al., 2003. Activity-guided isolation of novel norwithanolides from Deprea subtriflora with potential cancer chemopreventive activity. J. Org. Chem., 68: 2350-2361.
PubMed  |  
48:   Su, B.N., E.J. Park, D. Nikolic, J.S. Vigo and J. Graham et al., 2003. Isolation and characterization of miscellaneous secondary metabolites of Deprea subtriflora. J. Nat. Prod., 66: 1089-1093.
PubMed  |  
49:   Su, B.N., M. Cuendet, D. Nikolic, H. Kristinsson and K. Ingolfdottir et al., 2003. NMR study of fumarprotocetraric acid, a complex lichen depsidone derivative from Cladonia furcata. Magn. Reson. Chem., 41: 391-394.
Direct Link  |  
50:   Turner, A., S.N. Chen, D. Nikolic, R.B. van Breemen, N.R. Farnsworth and G.F. Pauli, 2007. Coumaroyl iridoids and a depside from cranberry (Vaccinium macrocarpon). J. Nat. Prod., 70: 253-258.
PubMed  |  
51:   Van Breemen, R.B., C.R. Huang, D. Nikolic, C.P. Woodbury, Y.Z. Zhao and D.L. Venton, 1997. Pulsed ultrafiltration mass spectrometry: A new method for screening combinatorial libraries. Anal. Chem., 69: 2159-2164.
CrossRef  |  Direct Link  |  
52:   Van Breemen, R.B., W. Liang, S. Banuvar, L. Shulman and Y. Pang et al., 2010. Pharmacokinetics of 23-epi-26-deoxyactein in women following oral administration of a standardized extract of Cimicifuga racemosa L. (Nutt.) (black cohosh). Clin. Pharmacol. Therapeut., 87: 219-225.
PubMed  |  
53:   Wang, Z., H. Yuan, D. Nikolic, R.B. van Breemen and R.B. Silverman, 2006. (±)-(1S,2R,5S)-5-amino-2-fluorocyclohex-3-ene carboxylic acid. A potent GABA aminotransferase inactivator that irreversibly inhibits through an elimination-aromatization pathway. Biochemistry, 45: 14513-14522.
PubMed  |  
54:   Yang, Y., D. Nikolic, S.M. Swanson and R.B. van Breemen, 2002. Quantitative determination of N7-Methyldeoxyguanosine and O6-Methyldeoxyguanosine in DNA by LC-UV-MS-MS. Anal. Chem., 74: 5376-5382.
55:   Yuan, Y., X. Qiu, D. Nikolic, J.H. Dahl and R.B. van Breemen, 2012. Method development and validation for UHPLC-MS-MS determination of hop prenylflavonoids in human serum. J. AOAC Int., 95: 1744-1749.
PubMed  |  
56:   Zhang, H.Q., R.P. Dixon, M.M. Marletta, D. Nikolic, R.B. van Breemen and R.B. Silverman, 1997. Mechanism of inactivation of neuronal nitric oxide synthase by N-allyl-L-arginine. J. Am. Chem. Soc., 119: 10888-10902.
Direct Link  |  
57:   Zhao, Y.Z., R.B. van Breemen, D. Nikolic, C.R. Huang, C.P. Woodbury, A.B. Schilling and D.L. Venton, 1997. Screening solution phase combinatorial libraries using pulsed ultrafiltration/electrospray mass spectrometry. J. Med. Chem., 40: 4006-4012.
PubMed  |  
58:   Zhu, Y., D. Nikolic, R.B. van Breemen and R.B. Silverman, 2005. Mechanism of inactivation of inducible nitric oxide synthase by amidines. Irreversible inactivation without inactivator modification. J. Am. Chem. Soc., 127: 858-868.
PubMed  |  
59:   van Breemen, R.B., D. Nikolic and J.L. Bolton, 1998. Metabolic screening using on-line ultrafiltration mass spectrometry. Drug Metab. Dispos., 26: 85-90.
PubMed  |  Direct Link  |