Dr. Dejan  Nikolic

Dr. Dejan Nikolic

Professor
University of Illinois, USA


Highest Degree
Ph.D. in Medicinal Chemistry from University of Illinois, USA

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Area of Interest:

Biomedical Sciences
100%
Natural Products
62%
Drug Discovery
90%
Medicinal Chemistry
75%
Mass Spectrometry
55%

Selected Publications

  1. Stanojkovic, T., B. Kolundzija, A. Ciric, M. Sokovic, D. Nikolic and T. Kundakovic, 2013. Cytotoxicity and antimicrobial activity of Satureja kitabelli Wirzb. Ex Heuff (Lamiaceae). Digest J. Nanomet. Nanostruct., 8: 845-854.

  2. Nikolic, D. and R.B. van Breemen, 2013. Analytical methods for quantitation of prenylated flavonoids from hops. Curr. Anal. Chem., 9: 71-85.
    PubMed  |  

  3. Kabirov, K.K., I.M. Kapetanovic, D.M. Benbrook, N. Dinger and I. Mankovskaya et al., 2013. Oral toxicity and pharmacokinetic studies of SHetA2, a new chemopreventive agent, in rats and dogs. Drug. Chem. Toxicol., 36: 284-295.
    PubMed  |  

  4. Yuan, Y., X. Qiu, D. Nikolic, J.H. Dahl and R.B. van Breemen, 2012. Method development and validation for UHPLC-MS-MS determination of hop prenylflavonoids in human serum. J. AOAC Int., 95: 1744-1749.
    PubMed  |  

  5. Nikolic, D., T. Goedecke, S.N. Chen, J. White, D. Lankin, G.F. Pauli and R.B. van Breemen, 2012. Mass spectrometric dereplication of nitrogen-containing constituents of black cohosh (Cimicifuga racemosa L.). Fitoterapia, 83: 441-460.
    PubMed  |  

  6. Hu, C., D. Nikolic, A.L. Eggler, A.D. Mesecar and R.B. van Breemen, 2012. Screening for natural chemoprevention agents that modify human Keap1. Anal. Biochem., 421: 108-114.
    PubMed  |  

  7. Godecke, T., P. Yao, J. Napolitano, D. Nikolic and B.M. Dietz et al., 2012. Integrated standardization concept for Angelica botanicals using quantitative NMR Fitoterapia, 83: 18-32.
    CrossRef  |  PubMed  |  

  8. Dong, S.H., D. Nikolic, C. Simmler, Q. Feng and R.B. van Breemen et al., 2012. Diarylheptanoids from Dioscorea villosa (Wild Yam). J. Nat. Prod., 75: 2168-2177.
    CrossRef  |  Direct Link  |  

  9. Li, J., T. Godecke, S.N. Chen, A. Imai and D.C. Lankin et al., 2011. In vitro metabolic interactions between black cohosh (Cimicifuga racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4. Xenobiotica, 41: 1021-1030.
    PubMed  |  

  10. Chen, S.N., B.J. Friesen, D. Webster, D. Nikolic and R.B. van Breemen et al., 2011. Chemical components from the fruits of Vitex agnus-castus. Fitoterapia 82: 528-533.

  11. Cao, H., R. Yu, Y. Tao, D. Nikolic and R.B. van Breemen, 2011. Measurement of cyclooxygenase inhibition using liquid chromatography-tandem mass spectrometry. J. Pharmaceut. Biomed. Anal., 54: 230-235.
    CrossRef  |  PubMed  |  Direct Link  |  

  12. Van Breemen, R.B., W. Liang, S. Banuvar, L. Shulman and Y. Pang et al., 2010. Pharmacokinetics of 23-epi-26-deoxyactein in women following oral administration of a standardized extract of Cimicifuga racemosa L. (Nutt.) (black cohosh). Clin. Pharmacol. Therapeut., 87: 219-225.
    PubMed  |  

  13. Nikolic, D., 2010. A liquid chromatography-mass spectrometric assay for measuring activity of human 8-oxoguanine-DNA-glycosylase. Anal. Biochem., 396: 275-279.
    PubMed  |  

  14. Inui, T., Y. Wang, D. Nikolic, S. Franzblau, D. Smith and G.F. Pauli, 2010. Sesquiterpenes from Oplopanax horridus. J. Nat. Prod., 73: 563-567.
    PubMed  |  

  15. Bolca, S., J. Li, D. Nikolic N. Roche and P. Blondeel et al., 2010. Disposition of hop prenylflavonoids in normal breast tissue. Mol. Nutr. Food. Res., 54: S284-S294.
    PubMed  |  

  16. Huang, Y., D. Nikolic, S. Pendland, B. Doyle, T.D. Locklear and G.B. Mahady, 2009. Effects of cranberry extracts on ursolic acid derivatives on P-fimbriated Escherichia coli, COX-2 activity, pro-inflammatory cytokine release and the NF-κβ transcriptional response in vitro. Pharm. Biol., 47: 18-25.
    PubMed  |  

  17. Godecke, T., D. Nikolic, D. Lankin, S.N. Chen and S.L. Powell et al., 2009. Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts. Phytochem. Anal., 20: 120-133.
    PubMed  |  

  18. Godecke, T., D. Lankin, D. Nikolic, S.N. Chen, R. van Breemen, N. Farnsworth and G.F. Pauli, 2009. Guanidine alkaloids and Pictet-Spengler adducts from black cohosh. J. Nat. Prod., 72: 433-437.
    PubMed  |  

  19. Geller, S.E., S. Banuvar, L.P. Shulman, G. Epstein and Y. Zhou et al., 2009. Efficacy and safety of black cohosh and red clover for the management of vasomotor symptoms: A randomized controlled trial. Menopause, 16: 1156-1166.
    PubMed  |  

  20. Powell, S.L., T. Godecke, D. Nikolic, S.N. Chen and B. Dietz et al., 2008. In vitro serotonergic activity of black cohosh (Cimicifuga racemosa) and identification of a potential active constituent, Nω-methylserotonin. J. Agric. Food Chem., 56: 11718-11726.
    PubMed  |  

  21. Guo, J., D. Liu, D. Nikolic, D. Zhu, J.M. Pezzuto and R.B. van Breemen, 2008. In vitro metabolism of isoliquiritigenin by human liver microsomes. Drug Metab. Dispos., 36: 461-468.
    PubMed  |  

  22. Chen, S.N., A. Turner, B. Jaki, D. Nikolic, R.B. van Breemen, B. Friesen and G.F. Pauli, 2008. An experimental implementation of chemical subtraction. J. Pharm. Biomed. Anal., 46: 692-698.
    CrossRef  |  PubMed  |  

  23. Turner, A., S.N. Chen, D. Nikolic, R.B. van Breemen, N.R. Farnsworth and G.F. Pauli, 2007. Coumaroyl iridoids and a depside from cranberry (Vaccinium macrocarpon). J. Nat. Prod., 70: 253-258.
    PubMed  |  

  24. Pang, Y., D. Nikolic, D. Zhu, L.R. Chadwick, G.F. Pauli, N.R. Farnsworth and R.B. van Breemen, 2007. Binding of the hop (Humulus lupulus L.) chalcone xanthohumol to cytosolic proteins in Caco-2 intestinal epithelial cells. Mol. Nutr. Food. Res., 51: 872-879.
    CrossRef  |  PubMed  |  

  25. Chen, S.N., D. Lankin, D. Nikolic, D.S. Fabricant and Z.Z. Lu et al., 2007. Chlorination diversifies Cimicifuga racemosa tripetrpene glycosides. J. Nat. Prod., 70: 1016-1023.
    PubMed  |  

  26. Wang, Z., H. Yuan, D. Nikolic, R.B. van Breemen and R.B. Silverman, 2006. (±)-(1S,2R,5S)-5-amino-2-fluorocyclohex-3-ene carboxylic acid. A potent GABA aminotransferase inactivator that irreversibly inhibits through an elimination-aromatization pathway. Biochemistry, 45: 14513-14522.
    PubMed  |  

  27. Nikolic, D., Y. Li, L.R. Chadwick and R.B. van Breemen, 2006. Intestinal permeability and hepatic metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus L.). Pharm. Res., 23: 864-872.

  28. Guo, J., D. Nikolic, L.R. Chadwick, G.F. Pauli and R.B. van Breemen, 2006. Identification of human hepatic cytochromes P450 isoforms involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.). Drug Metab. Dispos., 34: 1152-1159.

  29. Deng, S., S.N. Chen, P. Yao, D. Nikolic and R.B. van Breemen et al., 2006. Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis. J. Nat. Prod., 69: 536-541.
    PubMed  |  

  30. Deng, S., S.N. Chen, J. Lu, Z.J. Wang and D. Nikolic et al., 2006. GABAergic phthalide dimers from Angelica sinensis (Oliv.) diels. Phytochem. Anal., 17: 398-405.
    PubMed  |  

  31. Booth, N.L., C.R. Overk, P. Yao, J.E. Burdette and D. Nikolic et al., 2006. The chemical and biological profile of a red clover (Trifolium pretense) phase II clinical extract., J. Altern. Complement. Med., 12: 133-139.
    PubMed  |  

  32. Zhu, Y., D. Nikolic, R.B. van Breemen and R.B. Silverman, 2005. Mechanism of inactivation of inducible nitric oxide synthase by amidines. Irreversible inactivation without inactivator modification. J. Am. Chem. Soc., 127: 858-868.
    PubMed  |  

  33. Overk, C.R., P. Yao, L.R. Chadwick, D. Nikolic and Y. Sun et al., 2005. Comparison of estrogenic activities of pure compounds found in hops and red clover. J. Agric. Food Chem., 53: 6246-6253.

  34. Nikolic, D., Y. Li, L.R. Chadwick, G.F. Pauli and R.B. van Breemen, 2005. Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes. J. Mass Spectrom., 40: 289-299.
    PubMed  |  

  35. Fabricant, D., D. Nikolic, D. Lankin, S.N. Chen and B. Jaki et al., 2005. Cimipronidine: A cyclic guanidine alkaloid from Cimicifuga racemosa (L.) nutt. J. Nat. Prod., 68: 1266-1270.

  36. Nikolic, D., Y. Li, L.R. Chadwick, S. Grubjesic, P. Schwab and R.B. van Breemen, 2004. Metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus L.) by human liver microsomes. Drug Metab. Dispos., 32: 272-279.

  37. Nikolic, D. and R.B. van Breemen, 2004. New metabolic pathways for flavanones catalyzed by rat liver microsomes. Drug Metab. Dispos., 32: 387-397.
    PubMed  |  

  38. Liu, J., J. Burdette, Y. Sun, S. Deng and S.M. Schlecht et al., 2004. Isolation of linoleic acid as an estrogen-like compound from the fruits of Vitex agnus-castus L. (chaste berry). Phytomedicine, 11: 18-23.
    PubMed  |  

  39. Li, Y., S. Grubjesic, D. Nikolic, J.W. Kosmeder, R.M. Moriarty, J.M. Pezzuto and R.B. van Breemen, 2004. In vitro assessment of intestinal permeability and hepatic metabolism of 4'-bromoflavone, a promising cancer chemopreventive agent. Xenobiotica, 34: 535-547.
    PubMed  |  

  40. Li, Y., J. Yao, M. Chang, D. Nikolic and L. Yu et al., 2004. Equine catechol estrogen 4-hydroxyequilenin is a more potent inhibitor of the variant form of catechol-O-methyltransferase. Chem. Res. Toxicol., 17: 512-520.
    PubMed  |  

  41. Chadwick, L.R., D. Nikolic, J.E. Burdette, C.R. Overk and J.L. Bolton et al., 2004. Estrogens and congeners from spent hops. J. Nat. Prod., 67: 2024-2032.
    PubMed  |  

  42. Booth, N.L., D. Nikolic, S. Geller, R.B. van Breemen and S.E. Geller et al., 2004. Confusion regarding anticoagulant coumarins in dietary supplements. Clin. Pharmacol. Ther., 76: 511-516.
    PubMed  |  

  43. Su, B.N., M. Cuendet, D. Nikolic, H. Kristinsson and K. Ingolfdottir et al., 2003. NMR study of fumarprotocetraric acid, a complex lichen depsidone derivative from Cladonia furcata. Magn. Reson. Chem., 41: 391-394.
    Direct Link  |  

  44. Su, B.N., E.J. Park, D. Nikolic, J.S. Vigo and J. Graham et al., 2003. Isolation and characterization of miscellaneous secondary metabolites of Deprea subtriflora. J. Nat. Prod., 66: 1089-1093.
    PubMed  |  

  45. Su, B.N., E.J. Park, D. Nikolic, B.D. Santarsiero and A.D. Mesecar et al., 2003. Activity-guided isolation of novel norwithanolides from Deprea subtriflora with potential cancer chemopreventive activity. J. Org. Chem., 68: 2350-2361.
    PubMed  |  

  46. Lu, X., D. Nikolic, D. Mitchell, R.B. van Breemen, J.A. Mersfelder, R. Hille and R.B. Silverman, 2003. A mechanism for substrate-induced formation of 6-hydroxyflavin mononucleotide catalyzed by C30A trimethylamine dehydrogenase. Bioorg. Med. Chem. Lett., 13: 4129-4132.
    PubMed  |  

  47. Koloumbos, V.N., D.F. Tsipi, A.E. Hiskia, D. Nikolic and R.B. van Breemen, 2003. Identification of photocatalytic degradation products of diazinon in TiO2 aqueous suspensions using GC/MS/MS and LC-MS with quadrupole time-of-flight mass spectrometry. J. Am. Soc. Mass Spectrom., 14: 803-817.
    PubMed  |  

  48. Yang, Y., D. Nikolic, S.M. Swanson and R.B. van Breemen, 2002. Quantitative determination of N7-Methyldeoxyguanosine and O6-Methyldeoxyguanosine in DNA by LC-UV-MS-MS. Anal. Chem., 74: 5376-5382.

  49. Johnson, B., D. Nikolic and R.B. van Breemen, 2002. Applications of pulsed ultrafiltration mass spectrometry. Mass Spectrom. Rev., 21: 76-86.
    PubMed  |  

  50. Nikolic, D. and R.B. van Breemen, 2001. DNA oxidation induced by cyclooxygenase-2. Chem. Res. Toxicol., 14: 351-354.
    CrossRef  |  PubMed  |  Direct Link  |  

  51. Mitchell, D.J., D. Nikolic, R.B. van Breemen and R.B. Silverman, 2001. Inactivation of monoamine oxidase B by 1-phenylcyclopropylamine: Mass spectral evidence for the flavin adduct. Bioorg. Med. Chem. Lett., 11: 1757-1760.
    PubMed  |  

  52. Mitchell, D.J., D. Nikolic, E. Rivera, S.O. Sablin, R.B. van Breemen, T.P. Singer and R.B. Silverman, 2001. Spectrometric evidence for the flavin-1-phenylcyclopropylamine inactivator adduct with monoamine oxidase N. Biochemistry, 40: 5447-5456.
    PubMed  |  

  53. Mitchell, D.J. D. Nikolic, M.H. Jang, R.B. van Breemen, R. Hille and R.B. Silverman, 2001. Inactivation of C30A trimethylamine dehydrogenase by N-Cyclopropyl-a-methylbenzylamine, 1-phenylcyclopropylamine and phenylhydrazine. Biochemistry, 40: 8523-8530.
    PubMed  |  

  54. Nikolic, D., S.H. Goudarzi, D.G. Corley, S. Gafner, J.M. Pezzuto and R.B. van Breemen, 2000. Evaluation of cyclooxygenase-2 inhibitors using pulsed ultrafiltration-mass spectrometry. Anal. Chem., 72: 3853-3859.
    PubMed  |  

  55. Hamm, M.L., D. Nikolic, R.B. van Breemen and J.A. Piccirilli, 2000. Unconventional origin of metal ion rescue in the hammerhead ribozyme reaction: Mn2+ -assisted redox conversion of 2'-mercaptocytidine to cytidine. J. Am. Chem. Soc., 122: 12069-12078.
    Direct Link  |  

  56. van Breemen, R.B., D. Nikolic and J.L. Bolton, 1998. Metabolic screening using on-line ultrafiltration mass spectrometry. Drug Metab. Dispos., 26: 85-90.
    PubMed  |  Direct Link  |  

  57. Zhao, Y.Z., R.B. van Breemen, D. Nikolic, C.R. Huang, C.P. Woodbury, A.B. Schilling and D.L. Venton, 1997. Screening solution phase combinatorial libraries using pulsed ultrafiltration/electrospray mass spectrometry. J. Med. Chem., 40: 4006-4012.
    PubMed  |  

  58. Zhang, H.Q., R.P. Dixon, M.M. Marletta, D. Nikolic, R.B. van Breemen and R.B. Silverman, 1997. Mechanism of inactivation of neuronal nitric oxide synthase by N-allyl-L-arginine. J. Am. Chem. Soc., 119: 10888-10902.
    Direct Link  |  

  59. Van Breemen, R.B., C.R. Huang, D. Nikolic, C.P. Woodbury, Y.Z. Zhao and D.L. Venton, 1997. Pulsed ultrafiltration mass spectrometry: A new method for screening combinatorial libraries. Anal. Chem., 69: 2159-2164.
    CrossRef  |  Direct Link  |