Dr. Mario Dell Agli

Dr. Mario Dell Agli

Researcher
University of Milan, Italy


Highest Degree
Ph.D. in Pharmacology from University of Milan, Italy

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Area of Interest:

Pharmacology and Toxicology
100%
Pharmacognostical Research
62%
Pharmacotherapeutics
90%
Biotechnology
75%
Inflammation
55%

Education

2004

Ph.D.

University of Milan, Italy

Pharmacology

2000

M.Sc.

University of Milan, Italy

Experimental Pharmacology

1998

B.Sc.

University of Milan, Italy

Pharmaceutical Chemistry and Technology

Selected Publications

  1. Fumagalli, M., E. Sangiovanni, U. Vrhovsek, S. Piazza and M. Dell’Agli et al., 2016. Strawberry tannins inhibit IL-8 secretion in a cell model of gastric inflammation. Pharmacol. Res., 111: 703-712.
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  2. Di Lorenzo, C., E. Sangiovanni, M. Fumagalli, E. Colombo and M. Dell’Agli et al., 2016. Evaluation of the anti-inflammatory activity of raisins (Vitis vinifera L.) in human gastric epithelial cells: A comparative study. Int. J. Mol. Sci., 17: 1156-1156.
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  3. Sangiovanni, E., C. Di Lorenzo, E. Colombo, F. Colombo and M. Fumagalli et al., 2015. Effect of in vitro gastro-intestinal digestion on the anti-inflammatory activity of Vitis vinifera L. leaves. Food Funct., 6: 2453-2463.
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  4. Pancotti, A., S. Parapini, M. Dell’Agli, L. Gambini and C. Galli et al., 2015. Discovery of Oxybisbenzoylamides as a new class of antimalarial agents. Med. Chem. Commun., 6: 1173-1177.
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  5. Muto, E., M. Dell’Agli, E. Sangiovanni, N. Mitro and M. Fumagalli et al., 2015. Olive oil phenolic extract regulates interleukin-8 expression by transcriptional and posttranscriptional mechanisms in Caco-2 cells. Mol. Nutr. Food Res., 59: 1217-1221.
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  6. D’ Ambrosio, M., A. Ciocarlan, E. Colombo, A. Guerriero, C. Pizza, E. Sangiovanni, M. Dell’Agli, 2015. Structure and cytotoxic activity of sesquiterpene glycoside esters from Calendula officinalis L. : Studies on the conformation of viridiflorol. Phytochem., 117: 1-9.
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  7. Colombo, E., E. Sangiovanni, M. Fumagalli and M. Dell’Agli, 2015. Interactions between frugs and herbal drugs acting on the central nervous system. Giornale Italiano di Farmacoeconomia e Farmacoutilizzazione, 7: 5-20.

  8. Colombo, E., E. Sangiovanni, M. D’Ambrosio, E. Bosisio and A. Ciocarlan et al., 2015. A Bio-guided Fractionation to assess the inhibitory activity of Calendula officinalis L. on the NF-kB driven transcription in human gastric epithelial cells. Evidence-based Complementary Alter. Med., 10.1155/2015/727342.
    CrossRef  |  Direct Link  |  

  9. Magenta, D., E. Sangiovanni, N. Basilico, R.K. Haynes and M. Dell’Agli, 2014. Inhibition of metalloproteinase-9 secretion and gene expression by artemisinin derivatives. Acta Trop., 140: 77-83.
    CrossRef  |  Direct Link  |  

  10. Di Lorenzo, C., A. Dos Santos, F. Colombo, E. Moro, M. Dell’Agli and P. Restani, 2014. Development and validation of HPLC method to measure active amines in plant food supplements containing Citrus aurantium L. Food Control, 46: 136-142.
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  11. Sangiovanni, E., U. Vrhovsek, G. Rossoni, E. Colombo and M. Dell’Agli, et al., 2013. Ellagitannins form Rubus berries for the control of gastric inflammation: In vitro and in vivo studies. PloS One, 10.1371/journal.pone.0071762.
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  12. Molteni, R., F. Macchi, C. Zecchillo, M. Dell’Agli and E. Colombo et al., 2013. Modulation of the inflammatory response in rats chronically treated with the antidepressant agomelatine. Eur. Neuropsychopharmacol., 23: 1645-1655.
    CrossRef  |  Direct Link  |  

  13. Ilboudo, D.P., N. Basilico, S. Parapini, Y. Corbett and M. Dell’Agli, et al., 2013. Antiplasmodial and anti-inflammatory activities of canthium henriquesianum (K. Schum), a plant used in traditional medicine in burkina faso. J. Ethnopharmacol., 148: 763-769.
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  14. Di Lorenzo, C., M. Dell’Agli, M. Badea, L. Dima and E. Colombo et al., 2013. Plant food supplements with anti-inflammatory properties: A systematic review (II). Crit. Rev. Food Sci. Nutr., 53: 507-516.
    CrossRef  |  Direct Link  |  

  15. Di Lorenzo, C., M. Dell’Agli, E. Colombo, E. Sangiovanni, P. Restani, 2013. Metabolic syndrome and inflammation: A critical review of in vitro and clinical approaches for benefit assessment of plant food supplements. Evidence-Based Complementary Altern. Med., 10.1155/2013/782461.
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  16. Di Lorenzo, C., M. Dell’Agli, E. Sangiovanni, A. Dos Santos and F. Uberti et al., 2013. Correlation between catechin content and NF-kB inhibition by infusions of green and black tea. Plant Foods Hum. Nutr., 68: 149-154.
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  17. Dell’Agli, M., C. Di Lorenzo, M. Badea, E. Sangiovanni, L. Dima, E. Bosisio and P. Restani, 2013. Plant food supplements with anti-inflammatory properties: A systematic review (I). Crit. Rev. Food Sci. Nutr., 53: 403-413.
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  18. Colombo, E., E. Sangiovanni and M. Dell’Agli, 2013. A review on the anti-inflammatory activity of pomegranate in the gastrointestinal tract. Evidence-Based Complementary Altern. Med., 10.1155/2013/247145.
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  19. Vaiana, N., M. Melissa, P. Silvia, L. Peng and M. Dell’Agli et al., 2012. Antiplasmodial activities of 4-aminoquinoline–statine compounds. Bioorg. Med. Chem. Lett., 22: 5915-5918.
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  20. Sangiovanni, E., E. Colombo, M. Fumagalli, F. Abbiati, D. Caruso and M. Dell’Agli, 2012. Inhibition of NF-kB activity by minor polar components of extra-virgin olive oil at gastric level. Phytother. Res., 26: 1569-1571.
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  21. Dell’Agli, M., S. Cinzia, R. Patrizia, B. Nicoletta and C. Elisa et al., 2012. Anti-plasmodial and insecticidal activities of the essential oils of aromatic plants growing in the Mediterranean area. Malar. J., 10.1186/1475-2875-11-219.
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  22. Corsini, E., S. Enrico, A. Anna, M. Dell’Agli and R.G. Dori, 2012. In vitro characterization of the immunotoxic potential of several perfluorinated compounds (PFCs). Toxicol. Appl. Pharmacol., 258: 248-255.
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  23. Bulgari, M., E. Sangiovanni, E. Colombo, O. Maschi, D. Caruso, E. Bosisio and M. Dell’Agli, 2012. Inhibition of Neutrophil elastase and metalloprotease-9 of human adenocarcinoma gastric cells by Chamomile (Matricaria recutita L.) infusion. Phytother. Res., 26: 1817-1822.
    CrossRef  |  Direct Link  |  

  24. Cristofori, V., D. Caruso, G. Latini, M. Dell'Agli, C. Cammilli, E. Rugini and C. Bignami, 2011. Rosario muleo: Fruit quality of Italian pomegranate (Punica granatum L.) autochthonous varieties. Eur. Food Res. Technol., 10.1007/s00217-010-1390-8.
    CrossRef  |  

  25. Cristofori, V., C. Donatella, L. Gabriele, Mario Dell’Agli, C. Corrado, R. Eddo, B. Cristina and M. Rosario, 2011. Fruit quality of italian pomegranate (Punica granatum L.) autochthonous varieties. Eur. Food Res. Technol., 232: 397-403.
    CrossRef  |  Direct Link  |  

  26. Corsini, E., A. Avogadro, V. Galbiati, M. Dell'Agli, M. Marinovich, C.L. Galli and D.R. Germolec, 2011. In vitro evaluation of the immunotoxic potential of perfluorinated compounds (PFCs). Toxicol. Applied Pharmacol., 250: 108-116.
    CrossRef  |  

  27. Epis, R., E. Marcello, F. Gardoni, C. Vastagh and M. Malinverno et al., 2010. Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimers disease. Brain, 133: 3323-3335.
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  28. Dell'Agli, M., R. Fagnani, G.V. Galli, O. Maschi and F. Gilardi et al., 2010. Olive oil phenols modulate the expression of metalloproteinase 9 in THP-1 cells by acting on nuclear factor-kappaB signaling. J. Agric. Food Chem., 58: 2246-2252.
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  29. Dell'Agli, M., G.V. Galli, M. Bulgari, N. Basilico and S. Romeo et al., 2010. Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria. Malar. J., 9: 208-208.
    CrossRef  |  PubMed  |  Direct Link  |  

  30. Corsini, E., M. Dell'Agli, A. Facchi, E. De Fabiani and L. Lucchi et al., 2010. Enterodiol and enterolactone modulate the immune response by acting on nuclear factor-kappaB (NF-kappaB) signaling. J. Agric. Food Chem., 58: 6678-6684.
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  31. Dell'Agli, M., G.V. Galli, Y. Corbett, D. Taramelli and L. Lucantoni et al., 2009. Antiplasmodial activity of Punica granatum L. fruit rind. J. Ethnopharmacol., 125: 279-285.
    CrossRef  |  

  32. Dell'Agli, M., G.V. Galli, E. Bosisio and M. Dambrosio, 2009. Inhibition of NF-kB and metalloproteinase-9 expression and secretion by parthenolide derivatives. Bioorg. Med. Chem. Lett., 19: 1858-1860.
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  33. Romeo, S., S. Parapini, M. Dell'Agli, N. Vaiana and P. Magrone et al., 2008. Atovaquone-Statine double drugs with high antiplasmodial activity. Med. Chem. Parasitol., 3: 418-420.
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  34. Maschi, O., E.D. Cero, G.V. Galli, D. Caruso, E. Bosisio and M. Dell'Agli, 2008. Inhibition of human cAMP-phosphodiesterase as mechanism of the spasmolytic effect of Matricaria recutita L. J. Agric. Food Chem., 56: 5015-5020.
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  35. Galli, G.V., M. Dell'Agli, S. Parapini, N. Basilico and D. Taramelli et al., 2008. Anti-plasmodial activity of Ailanthus excelsa. Fitoterapia, 79: 112-116.
    CrossRef  |  PubMed  |  

  36. Dell'Agli, M., O. Maschi, G.V. Galli, R. Fagnani, E.D. Cero, D. Caruso and E. Bosisio, 2008. Inhibition of platelet aggregation by olive oil phenols via cAMP-phosphodiesterase. Br. J. Nutr., 99: 945-951.
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  37. Dell'Agli, M., G.V. Galli, E.D. Cero, F. Belluti and R. Matera et al., 2008. Potent inhibition of human phosphodiesterase-5 by icariin derivatives. J. Natural Products, 71: 1513-1517.
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  38. Basilico, N., E. Bosisio, F. Buelli, G. Campiani and M. Casagrande et al., 2008. Old and new targets for innovative antimalarial compounds: The different strategies of the Italian Malaria Network. Parassitologia, 50: 133-136.
    PubMed  |  Direct Link  |  

  39. Dell'Agli, M., F. Giavarini, P. Ferraboschi, G. Galli and E. Bosisio, 2007. Determination of aloesin and aloeresin a for the detection of aloe in beverages. J. Agric. Food Chem., 55: 3363-3367.
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  40. Dell'Agli, M., S. Parapini, G. Galli, N. Vaiana and D. Taramelli et al., 2006. High antiplasmodial activity of novel plasmepsin I and II inhibitors. J. Med. Chem., 49: 7440-7449.
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  41. Dell'Agli, M., R. Fagnani, N. Mitro, S. Scurati and M. Masciadri et al., 2006. Minor components of olive oil modulate pro-atherogenic adhesion molecules involved in endothelial activation. J. Agric. Food Chem., 54: 3259-3264.
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  42. Dell'Agli, M., G.V. Galli and E. Bosisio, 2006. Inhibition of cGMP-phosphodiesterase-5 by biflavones of Ginkgo biloba. Planta Medica, 72: 468-470.
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  43. Dell'Agli, M., S. Bellosta, L. Rizzi, G.V. Galli and M. Canavesi et al., 2005. A structure-activity study for the inhibition of metalloproteinase-9 activity and gene expression by analogues of gallocatechin-3-gallate. Cellular Mol. Life Sci., 62: 2896-2903.
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  44. Dell'Agli, M., M. Canavesi, G. Galli and S. Bellosta, 2005. Dietary polyphenols and regulation of gelatinases expression and activity. Thrombosis Haemostasis, 93: 751-760.
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  45. Dell'Agli, M., G.V. Galli, U. Vrhovsek, F. Mattivi and E. Bosisio, 2005. In vitro inhibition of human cGMP-specific phosphodiesterase-5 by polyphenols from red grapes. J. Agric. Food Chem., 53: 1960-1965.
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  46. Romeo, S., Mario Dell’Agli, P. Silvia, R. Luca and G. Germana et al., 2004. Plasmepsin II inhibition and antiplasmodial activity of Primaquine-Statine double drugs. Bioorg. Med. Chem. Lett., 14: 2931-2934.
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  47. Dell'Agli, M., A. Busciala and E. Bosisio, 2004. Vascular effects of wine polyphenols. Rev. Cardiovascular Res., 63: 593-602.
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  48. Bosisio, E., G. Flavio, M. Dell’Agli, G. Giovanni and G. Corrado, 2004. HPLC analysis of teucrin a in beverages flavoured with Teucrium chamaedrys L. hydroalcoholic extract. Food Food Addit. Contam., 21: 407-414.
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  49. Dell’Agli, M., P. Silvia, B. Nicoletta, V. Luisella, T. Donatella, B. Colin and B. Enrica, 2003. In vitro studies on the mechanism of action of two compounds with antiplasmodial activity: Ellagic acid and 3,4,5- trimethoxyphenyl- (6’-O-galloyl) - b - D -glucopyranoside. Planta Med., 69: 162-164.

  50. Bellosta, S., M. Dell’Agli, M. Canavesi, N. Mitro and M. Monetti et al., 2003. Inhibition of metalloproteinase-9 activity and gene expression by polyphenolic compounds isolated from the bark of Tristaniopsis calobuxus (Myrtaceae). Cell. Mol. Life Sci., 60: 1440-1448.
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  51. Dell’Agli, M and B. Enrica, 2002. Biflavones of Ginkgo biloba L. stimulate lipolysis in 3T3-L1 adipocytes. Planta Med., 68: 76-79.
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  52. Verotta, L., M. Dell’Agli, A. Giolito, M. Guerrini, P. Cabalion and E. Bosisio, 2001. In vitro antiplasmodial activity of extracts of tristaniopsis species (Myrtaceae) and identification of the active constituents: Ellagic acid and 3,4,5 trimethoxyphenyl-(6’-O-galloyl)-O-b-D-glucopyranoside. J. Nat. Prod., 64: 603-607.
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