Dr. Paolo M. Comoglio
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Dr. Paolo M. Comoglio

Dean
Candiolo Cancer Institute, Italy

Highest Degree
PostDoc Fellow in Medicine from Washington University, St. Louis, USA

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Area of Interest:

Biomedical Sciences
100%
Antiphosphotyrosine Antibody
62%
Protein Tyrosine Kinase
90%
Cancer Cell
75%
Physiological Mechanisms
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
362
Abstracts
0

Selected Publications

  1. Sponziello, M., S. Benvenuti, A. Gentile, V. Pecce and F. Rosignolo et al., 2018. Whole exome sequencing identifies a germline MET mutation in two siblings with hereditary wild-type RET medullary thyroid cancer. Hum. Mutat., 39: 371-377.
    CrossRef  |  Direct Link  |  
  2. Milan, M., S. Benvenuti, A.M. Balderacchi, A.R. Virzi and A. Gentile et al., 2018. RON tyrosine kinase mutations in brain metastases from lung cancer. ERJ Open Res., Vol. 4. 10.1183/23120541.00083-2017.
    CrossRef  |  Direct Link  |  
  3. Luraghi, P., V. Bigatto, E. Cipriano, G. Reato and F. Orzan et al., 2018. A molecularly annotated model of patient-derived colon cancer stem-like cells to assess genetic and nongenetic mechanisms of resistance to anti-EGFR therapy. Clin. Cancer Res., 24: 807-820.
    CrossRef  |  Direct Link  |  
  4. Stella, G.M., S. Benvenuti, A. Gentile and P.M. Comoglio, 2017. MET activation and physical dynamics of the metastatic process: The paradigm of cancers of unknown primary origin. EBioMedicine, 24: 34-42.
    CrossRef  |  Direct Link  |  
  5. Orzan, F., F. de Bacco, G. Crisafulli, S. Pellegatta and B. Mussolin et al., 2017. Genetic evolution of glioblastoma stem-like cells from primary to recurrent tumor. Stem Cells, 35: 2218-2228.
    CrossRef  |  Direct Link  |  
  6. Mira, A., V. Morello, M.V. Cespedes, T. Perera, P.M. Comoglio, R. Mangues and P. Michieli, 2017. Stroma-derived HGF drives metabolic adaptation of colorectal cancer to angiogenesis inhibitors. Oncotarget, 8: 38193-38213.
    CrossRef  |  Direct Link  |  
  7. Apicella, M., C. Migliore, T. Capeloa, S. Menegon and M. Cargnelutti et al., 2017. Dual MET/EGFR therapy leads to complete response and resistance prevention in a MET-amplified gastroesophageal xenopatient cohort. Oncogene, 36: 1200-1210.
    CrossRef  |  Direct Link  |  
  8. Sartore-Bianchi, A., L. Trusolino, C. Martino, K. Bencardino and S. Lonardi et al., 2016. Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): A proof-of-concept, multicentre, open-label, phase 2 trial. Lancet Oncol., 17: 738-746.
    CrossRef  |  Direct Link  |  
  9. Sala, V., S. Gallo, S. Gatti, E. Medico and E. Vigna et al., 2016. Cardiac concentric hypertrophy promoted by activated Met receptor is mitigated in vivo by inhibition of Erk1,2 signalling with Pimasertib. J. Mol. Cell. Cardiol., 93: 84-97.
    CrossRef  |  Direct Link  |  
  10. Pupo, E., N. Ducano, B. Lupo, E. Vigna and D. Avanzato et al., 2016. Rebound effects caused by withdrawal of MET kinase inhibitor are quenched by a MET therapeutic antibody. Cancer Res., 76: 5019-5029.
    CrossRef  |  Direct Link  |  
  11. Moran, S., A. Martinez-Cardus, S. Sayols, E. Musulen and C. Balana et al., 2016. Epigenetic profiling to classify cancer of unknown primary: A multicentre, retrospective analysis. Lancet Oncol., 17: 1386-1395.
    CrossRef  |  Direct Link  |  
  12. Lupo, B., J. Vialard, F. Sassi, P. Angibaud and A. Puliafito et al., 2016. Tankyrase inhibition impairs directional migration and invasion of lung cancer cells by affecting microtubule dynamics and polarity signals. BMC Biol., Vol. 14. 10.1186/s12915-016-0226-9.
    CrossRef  |  Direct Link  |  
  13. De Bacco, F., A. D'Ambrosio, E. Casanova, F. Orzan and R. Neggia et al., 2016. MET inhibition overcomes radiation resistance of glioblastoma stem-like cells. EMBO Mol. Med., 8: 550-568.
    CrossRef  |  Direct Link  |  
  14. D'Amico, L., D. Belisario, G. Migliardi, C. Grange and B. Bussolati et al., 2016. C-met inhibition blocks bone metastasis development induced by renal cancer stem cells. Oncotarget, 7: 45525-45537.
    CrossRef  |  Direct Link  |  
  15. Cignetto, S., C. Modica, C. Chiriaco, L. Fontani and P. Milla et al., 2016. Dual constant domain-Fab: A novel strategy to improve half‐life and potency of a Met therapeutic antibody. Mol. Oncol., 10: 938-948.
    CrossRef  |  Direct Link  |  
  16. Vigna, E., C. Chiriaco, S. Cignetto, L. Fontani, C. Basilico, F. Petronzelli and P.M. Comoglio, 2015. Inhibition of ligand-independent constitutive activation of the Met oncogenic receptor by the engineered chemically-modified antibody DN30. Mol. Oncol., 9: 1760-1772.
    CrossRef  |  Direct Link  |  
  17. Vigna, E. and P.M. Comoglio, 2015. Targeting the oncogenic Met receptor by antibodies and gene therapy. Oncogene, 34: 1883-1889.
    CrossRef  |  Direct Link  |  
  18. Cargnelutti, M., S. Corso, M. Pergolizzi, L. Mevellec and D.L. Aisner et al., 2015. Activation of RAS family members confers resistance to ROS1 targeting drugs. Oncotarget, 6: 5182-5194.
    CrossRef  |  Direct Link  |  
  19. Bigatto, V., F. de Bacco, E. Casanova, G. Reato and L. Lanzetti et al., 2015. TNF-α promotes invasive growth through the MET signaling pathway. Mol. Oncol., 9: 377-388.
    CrossRef  |  Direct Link  |  
  20. Vigna, E., G. Pacchiana, C. Chiriaco, S. Cignetto, L. Fontani, P. Michieli and P.M. Comoglio, 2014. Targeted therapy by gene transfer of a monovalent antibody fragment against the Met oncogenic receptor. J. Mol. Med., 92: 65-76.
    CrossRef  |  Direct Link  |  
  21. Rocci, A., M. Gambella, S. Aschero, I. Baldi and L. Trusolino et al., 2014. MET dysregulation is a hallmark of aggressive disease in multiple myeloma patients. Br. J. Haematol., 164: 841-850.
    CrossRef  |  Direct Link  |  
  22. Pennacchietti, S., M. Cazzanti, A. Bertotti, W.M. Rideout and M. Han et al., 2014. Microenvironment-derived HGF overcomes genetically determined sensitivity to anti-MET drugs. Cancer Res., 74: 6598-6609.
    CrossRef  |  Direct Link  |  
  23. Martin, V., S. Corso, P.M. Comoglio and S. Giordano, 2014. Increase of MET gene copy number confers resistance to a monovalent MET antibody and establishes drug dependence. Mol. Oncol., 8: 1561-1574.
    CrossRef  |  Direct Link  |  
  24. Luraghi, P., G. Reato, E. Cipriano, F. Sassi and F. Orzan et al., 2014. MET signaling in colon cancer stem-like cells blunts the therapeutic response to EGFR inhibitors. Cancer Res., 74: 1857-1869.
    CrossRef  |  Direct Link  |  
  25. Gentile, A., L. Lazzari, S. Benvenuti, L. Trusolino and P.M. Comoglio, 2014. The ROR1 pseudokinase diversifies signaling outputs in MET-addicted cancer cells. Int. J. Cancer, 135: 2305-2316.
    CrossRef  |  Direct Link  |  
  26. Gallo, S., S. Gatti, V. Sala, R. Albano and P. Costelli et al., 2014. Agonist antibodies activating the Met receptor protect cardiomyoblasts from cobalt chloride-induced apoptosis and autophagy. Cell Death Dis., Vol. 5. 10.1038/cddis.2014.155.
    CrossRef  |  Direct Link  |  
  27. Boccaccio, C., P. Luraghi and P.M. Comoglio, 2014. MET-mediated resistance to EGFR inhibitors: An old liaison rooted in colorectal cancer stem cells. Cancer Res., 74: 3647-3651.
    CrossRef  |  Direct Link  |  
  28. Boccaccio, C. and P.M. Comoglio, 2014. MET, a driver of invasive growth and cancer clonal evolution under therapeutic pressure. Curr. Opin. Cell Biol., 31: 98-105.
    CrossRef  |  Direct Link  |  
  29. Benvenuti, S., A. Gentile, L. Lazzari, A. Arnesano, L. Trusolino and P.M. Comoglio, 2014. An 'in-cell trial' to assess the efficacy of a monovalent anti-MET antibody as monotherapy and in association with standard cytotoxics. Mol. Oncol., 8: 378-388.
    CrossRef  |  Direct Link  |  
  30. Stella, G.M., M. Luisetti, E. Pozzi and P.M. Comoglio, 2013. Oncogenes in non-small-cell lung cancer: Emerging connections and novel therapeutic dynamics. Lancet Respir. Med., 1: 251-261.
    CrossRef  |  Direct Link  |  
  31. Gastaldi, S., F. Sassi, P. Accornero, D. Torti and F. Galimi et al., 2013. Met signaling regulates growth, repopulating potential and basal cell-fate commitment of mammary luminal progenitors: Implications for basal-like breast cancer. Oncogene, 32: 1428-1440.
    CrossRef  |  Direct Link  |  
  32. Burbridge, M.F., C.J. Bossard, C. Saunier, I. Fejes and A. Bruno et al., 2013. S49076 is a novel kinase inhibitor of MET, AXL and FGFR with strong preclinical activity alone and in association with bevacizumab. Mol. Cancer Therapeut., 12: 1749-1762.
    CrossRef  |  Direct Link  |  
  33. Boccaccio, C. and P.M. Comoglio, 2013. The MET oncogene in glioblastoma stem cells: Implications as a diagnostic marker and a therapeutic target. Cancer Res., 73: 3193-3199.
    CrossRef  |  Direct Link  |  
  34. Bardelli, A., S. Corso, A. Bertotti, S. Hobor and E. Valtorta et al., 2013. Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer. Cancer Discov., 3: 658-673.
    CrossRef  |  Direct Link  |  
  35. Torti, D., F. Sassi, F. Galimi, S. Gastaldi and T. Perera et al., 2012. A preclinical algorithm of soluble surrogate biomarkers that correlate with therapeutic inhibition of the MET oncogene in gastric tumors. Int. J. Cancer, 130: 1357-1366.
    CrossRef  |  Direct Link  |  
  36. Migliore, C., V. Martin, V.P. Leoni, A. Restivo and L. Atzori et al., 2012. MiR-1 downregulation cooperates with MACC1 in promoting MET overexpression in human colon cancer. Clin. Cancer Res., 18: 737-747.
    CrossRef  |  PubMed  |  Direct Link  |  
  37. Migliardi, G., F. Sassi, D. Torti, F. Galimi and E.R. Zanella et al., 2012. Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas. Clin. Cancer Res., 18: 2515-2525.
    CrossRef  |  Direct Link  |  
  38. De Bacco, F., E. Casanova, E. Medico, S. Pellegatta and F. Orzan et al., 2012. The MET oncogene is a functional marker of a glioblastoma stem cell subtype. Cancer Res., 72: 4537-4550.
    CrossRef  |  Direct Link  |  
  39. Stella, G.M., S. Benvenuti, D. Gramaglia, A. Scarpa and A. Tomezzoli et al., 2011. MET mutations in Cancers of Unknown Primary origin (CUPs). Hum. Mutat., 32: 44-50.
    CrossRef  |  Direct Link  |  
  40. Schelter, F., M. Grandl, B. Seubert, S. Schaten and S. Hauser et al., 2011. Tumor cell-derived Timp-1 is necessary for maintaining metastasis-promoting Met-signaling via inhibition of Adam-10. Clin. Exp. Metastasis, 28: 793-802.
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  41. Hwang, C.I., A. Matoso, D.C. Corney, A. Flesken-Nikitin and S. Korner et al., 2011. Wild-type p53 controls cell motility and invasion by dual regulation of MET expression. Proc. Natl. Acad. Sci. USA., 108: 14240-14245.
    CrossRef  |  Direct Link  |  
  42. Gentile, A., L. Lazzari, S. Benvenuti, L. Trusolino and P.M. Comoglio, 2011. Ror1 is a pseudokinase that is crucial for Met-driven tumorigenesis. Cancer Res., 71: 3132-3141.
    CrossRef  |  Direct Link  |  
  43. Galimi, F., D. Torti, F. Sassi, C. Isella and D. Cora et al., 2011. Genetic and expression analysis of MET, MACC1 and HGF in metastatic colorectal cancer: Response to met inhibition in patient xenografts and pathologic correlations. Clin. Cancer Res., 17: 3146-3156.
    CrossRef  |  Direct Link  |  
  44. De Bacco, F., P. Luraghi, E. Medico, G. Reato and F. Girolami et al., 2011. Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer. J. Natl. Cancer Inst., 103: 645-661.
    CrossRef  |  Direct Link  |  
  45. Bertotti, A., G. Migliardi, F. Galimi, F. Sassi and D. Torti et al., 2011. A molecularly annotated platform of patient-derived xenografts (“xenopatients”) identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer. Cancer Discov., 1: 508-523.
    CrossRef  |  Direct Link  |  
  46. Benvenuti, S., L. Lazzari, A. Arnesano, G.L. Chiavi, A. Gentile and P.M. Comoglio, 2011. Ron kinase transphosphorylation sustains MET oncogene addiction. Cancer Res., 71: 1945-1955.
    CrossRef  |  Direct Link  |  
  47. Trusolino, L., A. Bertotti and P.M. Comoglio, 2010. MET signalling: Principles and functions in development, organ regeneration and cancer. Nat. Rev. Mol. Cell Biol., 11: 834-848.
    CrossRef  |  Direct Link  |  
  48. Stella, G.M., S. Benvenuti and P.M. Comoglio, 2010. Targeting the MET oncogene in cancer and metastases. Expert Opin. Invest. Drugs, 19: 1381-1394.
    CrossRef  |  Direct Link  |  
  49. Schelter, F., J. Kobuch, M.L. Moss, J.D. Becherer, P.M. Comoglio, C. Boccaccio and A. Kruger, 2010. A Disintegrin and Metalloproteinase-10 (ADAM-10) mediates DN30 antibody-induced shedding of the met surface receptor. J. Biol. Chem., 285: 26335-26340.
    CrossRef  |  Direct Link  |  
  50. Pacchiana, G., C. Chiriaco, M.C. Stella, F. Petronzelli and R. de Santis et al., 2010. Monovalency unleashes the full therapeutic potential of the DN-30 anti-Met antibody. J. Biol. Chem., 285: 36149-36157.
    CrossRef  |  Direct Link  |  
  51. Gastaldi, S., P.M. Comoglio and L. Trusolino, 2010. The Met oncogene and basal-like breast cancer: Another culprit to watch out for? Breast Cancer Res., Vol. 12. 10.1186/bcr2617.
    CrossRef  |  Direct Link  |  
  52. Franco, M., C. Muratori, S. Corso, E. Tenaglia and A. Bertotti et al., 2010. The tetraspanin CD151 is required for Met-dependent signaling and tumor cell growth. J. Biol. Chem., 285: 38756-38764.
    CrossRef  |  Direct Link  |  
  53. Corso, S., E. Ghiso, V. Cepero, J.R. Sierra and C. Migliore et al., 2010. Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition. Mol. Cancer, Vol. 9. 10.1186/1476-4598-9-121.
    CrossRef  |  Direct Link  |  
  54. Cepero, V., J.R. Sierra, S. Corso, E. Ghiso and L. Casorzo et al., 2010. MET and KRAS gene amplification mediates acquired resistance to MET tyrosine kinase inhibitors. Cancer Res., 70: 7580-7590.
    CrossRef  |  Direct Link  |  
  55. Casazza, A., V. Finisguerra, L. Capparuccia, A. Camperi and J.M. Swiercz et al., 2010. Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice. J. Clin. Invest., 120: 2684-2698.
    CrossRef  |  Direct Link  |  
  56. Cantelmo, A.R., R. Cammarota, D.M. Noonan, C. Focaccetti, P.M. Comoglio, M. Prat and A. Albini, 2010. Cell delivery of Met docking site peptides inhibit angiogenesis and vascular tumor growth. Oncogene, 29: 5286-5298.
    CrossRef  |  Direct Link  |  
  57. Bertotti, A., C. Bracco, F. Girolami, D. Torti and S. Gastaldi et al., 2010. Inhibition of Src impairs the growth of met-addicted gastric tumors. Clin. Cancer Res., 16: 3933-3943.
    CrossRef  |  Direct Link  |  
  58. Stella, M.C., L. Trusolino and P.M. Comoglio, 2009. The Slit/Robo system suppresses hepatocyte growth factor-dependent invasion and morphogenesis. Mol. Biol. Cell, 20: 642-657.
    CrossRef  |  Direct Link  |  
  59. Galluzzo, M., S. Pennacchietti, S. Rosano, P.M. Comoglio and P. Michieli, 2009. Prevention of hypoxia by myoglobin expression in human tumor cells promotes differentiation and inhibits metastasis. J. Clin. Invest., 119: 865-875.
    CrossRef  |  Direct Link  |  
  60. Finkbeiner, M.R., A. Astanehe, K. To, A. Fotovati and A.H. Davies et al., 2009. Profiling YB-1 target genes uncovers a new mechanism for MET receptor regulation in normal and malignant human mammary cells. Oncogene, 28: 1421-1431.
    CrossRef  |  Direct Link  |  
  61. Boccaccio, C. and P.M. Comoglio, 2009. Genetic link between cancer and thrombosis. J. Clin. Oncol., 27: 4827-4833.
    CrossRef  |  Direct Link  |  
  62. Balakrishnan, A., J.Y. Penachioni, S. Lamba, F.E. Bleeker and C. Zanon et al., 2009. Molecular profiling of the “plexinome” in melanoma and pancreatic cancer. Hum. Mutat., 30: 1167-1174.
    CrossRef  |  Direct Link  |  
  63. Zucali, P.A., M.G. Ruiz, E. Giovannetti, A. Destro and M. Varella-Garcia et al., 2008. Role of cMET expression in non-small-cell lung cancer patients treated with EGFR tyrosine kinase inhibitors. Ann. Oncol., 19: 1605-1612.
    CrossRef  |  Direct Link  |  
  64. Vigna, E., G. Pacchiana, M. Mazzone, C. Chiriaco and L. Fontani et al., 2008. “Active” cancer immunotherapy by anti-Met antibody gene transfer. Cancer Res., 68: 9176-9183.
    CrossRef  |  Direct Link  |  
  65. Takahara, T., F. Xue, M. Mazzone, Y. Yata and K. Nonome et al., 2008. Metron factor-1 prevents liver injury without promoting tumor growth and metastasis. Hepatology, 47: 2010-2025.
    CrossRef  |  Direct Link  |  
  66. Sierra, J.R., S. Corso, L. Caione, V. Cepero and P. Conrotto et al., 2008. Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages. J. Exp. Med., 205: 1673-1685.
    CrossRef  |  Direct Link  |  
  67. Rolny, C., L. Capparuccia, A. Casazza, M. Mazzone and A. Vallario et al., 2008. The tumor suppressor semaphorin 3B triggers a prometastatic program mediated by interleukin 8 and the tumor microenvironment. J. Exp. Med., 205: 1155-1171.
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  68. Perk, L.R., M. Stigter-van Walsum, G.W.M. Visser, R.W. Kloet and M.J. Vosjan et al., 2008. Quantitative PET imaging of Met-expressing human cancer xenografts with 89Zr-labelled monoclonal antibody DN30. Eur. J. Nucl. Med. Mol. Imaging, 35: 1857-1867.
    CrossRef  |  Direct Link  |  
  69. Migliore, C., A. Petrelli, E. Ghiso, S. Corso and L. Capparuccia et al., 2008. MicroRNAs impair MET-mediated invasive growth. Cancer Res., 68: 10128-10136.
    CrossRef  |  Direct Link  |  
  70. Gentile, A., L. Trusolino and P.M. Comoglio, 2008. The Met tyrosine kinase receptor in development and cancer. Cancer Metastasis Rev., 27: 85-94.
    CrossRef  |  Direct Link  |  
  71. Gentile, A., L. D'Alessandro, L. Lazzari, B. Martinoglio and A. Bertotti et al., 2008. Met-driven invasive growth involves transcriptional regulation of Arhgap12. Oncogene, 27: 5590-5598.
    CrossRef  |  Direct Link  |  
  72. Corso, S., C. Migliore, E. Ghiso, G. de Rosa, P.M. Comoglio and S. Giordano, 2008. Silencing the MET oncogene leads to regression of experimental tumors and metastases. Oncogene, 27: 684-693.
    CrossRef  |  Direct Link  |  
  73. Comoglio, P.M., S. Giordano and L. Trusolino, 2008. Drug development of MET inhibitors: Targeting oncogene addiction and expedience. Nat. Rev. Drug Discov., 7: 504-516.
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  74. Cassano, M., S. Biressi, A. Finan, L. Benedetti and C. Omes et al., 2008. Magic-factor 1, a partial agonist of Met, induces muscle hypertrophy by protecting myogenic progenitors from apoptosis. PLoS ONE, Vol. 3. 10.1371/journal.pone.0003223.
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  75. Basilico, C., A. Arnesano, M. Galluzzo, P.M. Comoglio and P. Michieli, 2008. A high affinity hepatocyte growth factor-binding site in the immunoglobulin-like region of Met. J. Biol. Chem., 283: 21267-21277.
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  76. Rasola, A., M. Fassetta, F. de Bacco, L. D'Alessandro, D. Gramaglia, M.F. Di Renzo and P.M. Comoglio, 2007. A positive feedback loop between hepatocyte growth factor receptor and β-catenin sustains colorectal cancer cell invasive growth. Oncogene, 26: 1078-1087.
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  77. Fazzari, P., J. Penachioni, S. Gianola, F. Rossi and B.J. Eickholt et al., 2007. Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis. BMC Dev. Biol., Vol. 7. 10.1186/1471-213X-7-55.
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  78. Comoglio, P., L. Trusolino and C. Boccaccio, 2007. Scatter factor-dependent branching morphogenesis: Structural and histological features. Eur. J. Histochem., 51: 79-92.
    PubMed  |  
  79. Benvenuti, S. and P.M. Comoglio, 2007. The MET receptor tyrosine kinase in invasion and metastasis. J. Cell. Physiol., 213: 316-325.
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  80. Arena, S., A. Pisacane, M. Mazzone, P.M. Comoglio and A. Bardelli, 2007. Genetic targeting of the kinase activity of the Met receptor in cancer cells. Proc. Natl. Acad. Sci. USA., 104: 11412-11417.
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  81. Petrelli, A., P. Circosta, L. Granziero, M. Mazzone and A. Pisacane et al., 2006. Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity. Proc. Natl. Acad. Sci. USA., 103: 5090-5095.
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  82. Patane, S., S. Avnet, N. Coltella, B. Costa and S. Sponza et al., 2006. MET overexpression turns human primary osteoblasts into osteosarcomas. Cancer Res., 66: 4750-4757.
    CrossRef  |  Direct Link  |  
  83. Mazzone, M. and P.M. Comoglio, 2006. The Met pathway: Master switch and drug target in cancer progression. FASEB J., 20: 1611-1621.
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  84. Coltella, N., A. Rasola, E. Nano, C. Bardella and M. Fassetta et al., 2006. p38 MAPK turns hepatocyte growth factor to a death signal that commits ovarian cancer cells to chemotherapy-induced apoptosis. Int. J. Cancer, 118: 2981-2990.
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  85. Boccaccio, C. and P.M. Comoglio, 2006. Invasive growth: A MET-driven genetic programme for cancer and stem cells. Nat. Rev. Cancer, 6: 637-645.
    CrossRef  |  Direct Link  |  
  86. Bertotti, A., P.M. Comoglio and L. Trusolino, 2006. β4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth. J. Cell Biol., 175: 993-1003.
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  87. Valabrega, G., F. Montemurro, I. Sarotto, A. Petrelli and P. Rubini et al., 2005. TGFα expression impairs Trastuzumab-induced HER2 downregulation. Oncogene, 24: 3002-3010.
    CrossRef  |  Direct Link  |  
  88. Stella, M.C., L. Trusolino, S. Pennacchietti and P.M. Comoglio, 2005. Negative feedback regulation of Met-dependent invasive growth by Notch. Mol. Cell. Biol., 25: 3982-3996.
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  89. Ghigna, C., S. Giordano, H. Shen, F. Benvenuto and F. Castiglioni et al., 2005. Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene. Mol. Cell, 20: 881-890.
    CrossRef  |  Direct Link  |  
  90. Corso, S., P.M. Comoglio and S. Giordano, 2005. Cancer therapy: Can the challenge be MET? Trends Mol. Med., 11: 284-292.
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  91. Conrotto, P., D. Valdembri, S. Corso, G. Serini and L. Tamagnone et al., 2005. Sema4D induces angiogenesis through Met recruitment by Plexin B1. Blood, 105: 4321-4329.
    CrossRef  |  Direct Link  |  
  92. Comoglio, P.M. and L. Trusolino, 2005. Cancer: The matrix is now in control. Nature Med., 11: 1156-1159.
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  93. Christensen, C., N. Ambartsumian, G. Gilestro, B. Thomsen and P. Comoglio et al., 2005. Proteolytic processing converts the repelling signal Sema3E into an inducer of invasive growth and lung metastasis. Cancer Res., 65: 6167-6177.
    CrossRef  |  Direct Link  |  
  94. Boccaccio, C., G. Sabatino, E. Medico, F. Girolami and A. Follenzi et al., 2005. The MET oncogene drives a genetic programme linking cancer to haemostasis. Nature, 434: 396-400.
    CrossRef  |  Direct Link  |  
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  189. Maina, F., F. Casagranda, E. Audero, A. Simeone, P.M. Comoglio, R. Klein and C. Ponzetto, 1996. Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development. Cell, 87: 531-542.
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  190. Maier, J.A.M., M. Mariotti, P.M. Comoglio and M.R. Soria, 1996. Interleukin 1 induces an autocrine loop hepatocyte growth factor/c-Met in murine Kaposi-like spindle cells. Oncogene, 13: 1009-1015.
    PubMed  |  
  191. Maestrini, E., L. Tamagnone, P. Longati, O. Cremona and M. Gulisano et al., 1996. A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor. Proc. Natl. Acad. Sci., 93: 674-678.
    CrossRef  |  Direct Link  |  
  192. Longati, P., D. Albero and P.M. Comoglio, 1996. Hepatocyte growth factor is a pleiotropic factor protecting epithelial cells from apoptosis. Cell Death Differ., 3: 23-28.
    PubMed  |  
  193. Graziani, A., F. Galimi, E. Medico, E. Cottone, D. Gramaglia, C. Boccaccio and P.M. Comoglio, 1996. The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation 1. J. Biol. Chem., 271: 6590-6593.
    CrossRef  |  Direct Link  |  
  194. Grano, M., F. Galimi, G. Zambonin, S. Colucci, E. Cottone, A.Z. Zallone and P.M. Comoglio, 1996. Hepatocyte growth factor is a coupling factor for osteoclasts and osteoblasts in vitro. Proc. Natl. Acad. Sci. USA., 93: 7644-7648.
    CrossRef  |  Direct Link  |  
  195. Gambarotta, G., C. Boccaccio, S. Giordano, M. Ando, M.C. Stella and P.M. Comoglio, 1996. Ets up-regulates MET transcription. Oncogene, 13: 1911-1917.
    PubMed  |  
  196. Ferracini, R., M. Olivero, M.F. di Renzo, M. Martano and C. de Giovanni et al., 1996. Retrogenic expression of the MET proto-oncogene correlates with the invasive phenotype of human rhabdomyosarcomas. Oncogene, 12: 1697-1705.
    PubMed  |  
  197. Comoglio, P.M. and C. Boccaccio, 1996. The HGF receptor family: Unconventional signal transducers for invasive cell growth. Genes Cells, 1: 347-354.
    CrossRef  |  PubMed  |  Direct Link  |  
  198. Collesi, C., M.M. Santoro, G. Gaudino and P.M. Comoglio, 1996. A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype. Mol. Cell. Biol., 16: 5518-5526.
    CrossRef  |  PubMed  |  Direct Link  |  
  199. Bardelli, A., P. Longati, D. Albero, S. Goruppi, C. Schneider, C. Ponzetto and P.M. Comoglio, 1996. HGF receptor associates with the anti‐apoptotic protein BAG‐1 and prevents cell death. EMBO J., 15: 6205-6212.
    CrossRef  |  Direct Link  |  
  200. Silvagno, F., A. Follenzi, M. Arese, M. Prat and E. Giraudo et al., 1995. In vivo activation of met tyrosine kinase by heterodimeric hepatocyte growth factor molecule promotes angiogenesis. Arterioscler. Thromb. Vasc. Biol., 15: 1857-1865.
    CrossRef  |  Direct Link  |  
  201. Ridley, A.J., P.M. Comoglio and A. Hall, 1995. Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac and Rho in MDCK cells. Mol. Cell. Biol., 15: 1110-1122.
    CrossRef  |  Direct Link  |  
  202. Naldini, L., E. Vigna, A. Bardelli, A. Follenzi, F. Galimi and P.M. Comoglio, 1995. Biological activation of pro-HGF (hepatocyte growth factor) by urokinase is controlled by a stoichiometric reaction. J. Biol. Chem., 270: 603-611.
    CrossRef  |  Direct Link  |  
  203. Grigioni, W.F., M. Fiorentino, A. d'Errico, A. Ponzetto, T. Crepaldi, M. Prat and P.M. Comoglio, 1995. Overexpression of c‐met protooncogene product and raised Ki67 index in hepatocellular carcinomas with respect to benign liver conditions. Hepatology, 21: 1543-1546.
    CrossRef  |  Direct Link  |  
  204. Gaudino, G., V. Avantaggiato, A. Follenzi, D. Acampora, A. Simeone and P.M. Comoglio, 1995. The proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissues. Oncogene, 11: 2627-2637.
    PubMed  |  
  205. Ferracini, R., M.F. di Renzo, K. Scotlandi, N. Baldini and M. Olivero et al., 1995. The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit. Oncogene, 10: 739-749.
    PubMed  |  
  206. Di Renzo, M.F., R. Poulsom, M. Olivero, P.M. Comoglio and N.R. Lemoine, 1995. Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer. Cancer Res., 55: 1129-1138.
    Direct Link  |  
  207. Zhen, Z., S. Giordano, P. Longati, E. Medico, M. Campiglio and P.M. Comoglio, 1994. Structural and functional domains critical for constitutive activation of the HGF-receptor (Met). Oncogene, 9: 1691-1697.
    PubMed  |  
  208. Yamada, T., H. Tsubouchi, Y. Daikuhara, M. Prat, P.M. Comoglio, P.L. McGeer and E.G. McGeer, 1994. Immunohistochemistry with antibodies to hepatocyte growth factor and its receptor protein (c-MET) in human brain tissues. Brain Res., 637: 308-312.
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  209. Vigna, E., L. Naldini, L. Tamagnone, P. Longati and A. Bardelli et al., 1994. Hepatocyte growth factor and its receptor, the tyrosine kinase encoded by the c-MET proto-oncogene. Cell. Mol. Biol. (Noisy-le-Grand, France), 40: 597-604.
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  210. Ponzetto, C., A. Bardelli, Z. Zhen, F. Maina and P. dalla Zonca et al., 1994. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell, 77: 261-271.
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  211. Longati, P., A. Bardelli, C. Ponzetto, L. Naldini and P.M. Comoglio, 1994. Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor). Oncogene, 9: 49-57.
    PubMed  |  
  212. Gaudino, G., A. Follenzi, L. Naldini, C. Collesi and M. Santoro et al., 1994. RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. EMBO J., 13: 3524-3532.
    CrossRef  |  Direct Link  |  
  213. Gandino, L., P. Longati, E. Medico, M. Prat and P.M. Comoglio, 1994. Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase. J. Biol. Chem., 269: 1815-1820.
    Direct Link  |  
  214. Gambarotta, G., S. Pistoi, S. Giordano, P.M. Comoglio and C. Santoro, 1994. Structure and inducible regulation of the human MET promoter. J. Biol. Chem., 269: 12852-12857.
    Direct Link  |  
  215. Galimi, F., G.P. Bagnara, L. Bonsi, E. Cottone, A. Follenzi, A. Simeone and P.M. Comoglio, 1994. Hepatocyte growth factor induces proliferation and differentiation of multipotent and erythroid hemopoietic progenitors. J. Cell Biol., 127: 1743-1754.
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  216. Di Renzo, M.F., M. Olivero, D. Katsaros, T. Crepaldi and P. Gaglia et al., 1994. Overexpression of the Met/HGF receptor in ovarian cancer. Int. J. Cancer, 58: 658-662.
    CrossRef  |  Direct Link  |  
  217. Crepaldi, T., M. Prat, S. Giordano, E. Medico and P.M. Comoglio, 1994. Generation of a truncated hepatocyte growth factor receptor in the endoplasmic reticulum. J. Biol. Chem., 269: 1750-1755.
    Direct Link  |  
  218. Crepaldi, T., A.L. Pollack, M. Prat, A. Zborek, K. Mostov and P.M. Comoglio, 1994. Targeting of the SF/HGF receptor to the basolateral domain of polarized epithelial cells. J. Cell Biol., 125: 313-320.
    CrossRef  |  Direct Link  |  
  219. Boccaccio, C., G. Gaudino, G. Gambarotta, F. Galimi and P.M. Comoglio, 1994. Hepatocyte growth factor (HGF) receptor expression is inducible and is part of the delayed-early response to HGF. J. Biol. Chem., 269: 12846-12851.
    Direct Link  |  
  220. Bellusci, S., G. Moens, G. Gaudino, P. Comoglio, T. Nakamura, J.P. Thiery and J. Jouanneau, 1994. Creation of an hepatocyte growth factor/scatter factor autocrine loop in carcinoma cells induces invasive properties associated with increased tumorigenicity. Oncogene, 9: 1091-1099.
    PubMed  |  
  221. Bardelli, A., C. Ponzetto and P.M. Comoglio, 1994. Identification of functional domains in the hepatocyte growth factor and its receptor by molecular engineering. J. Biotechnol., 37: 109-122.
    CrossRef  |  Direct Link  |  
  222. Weidner, K.M., G. Hartmann, L. Naldini, P.M. Comoglio and M. Sachs et al., 1993. Molecular characteristics of HGF-SF and its role in cell motility and invasion. EXS., 65: 311-328.
    PubMed  |  
  223. Villa-Moruzzi, E., S. Lapi, M. Prat, G. Gaudino and P.M. Comoglio, 1993. A protein tyrosine phosphatase activity associated with the hepatocyte growth factor/scatter factor receptor. J. Biol. Chem., 268: 18176-18180.
    Direct Link  |  
  224. Ponzetto, C., A. Bardelli, F. Maina, P. Longati and G. Panayotou et al., 1993. A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor. Mol. Cell. Biol., 13: 4600-4608.
    CrossRef  |  Direct Link  |  
  225. Natali, P.G., M.R. Nicotra, M.F. di Renzo, M. Prat, A. Bigotti, R. Cavaliere and P.M. Comoglio, 1993. Expression of the c-Met/HGF receptor in human melanocytic neoplasms: Demonstration of the relationship to malignant melanoma tumour progression. Br. J. Cancer, 68: 746-750.
    CrossRef  |  PubMed  |  Direct Link  |  
  226. Graziani, A., D. Gramaglia, P. dalla Zonca and P.M. Comoglio, 1993. Hepatocyte growth factor/scatter factor stimulates the Ras-guanine nucleotide exchanger. J. Biol. Chem., 268: 9165-9168.
    PubMed  |  Direct Link  |  
  227. Giordano, S., Z. Zhen, E. Medico, G. Gaudino, F. Galimi and P.M. Comoglio, 1993. Transfer of motogenic and invasive response to scatter factor/hepatocyte growth factor by transfection of human MET protooncogene. Proc. Natl. Acad. Sci., 90: 649-653.
    CrossRef  |  Direct Link  |  
  228. Galimi, F., M.F. Brizzi and P.M. Comoglio, 1993. The hepatocyte growth factor and its receptor. Stem Cells, 11: 22-30.
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  229. Di Renzo, M.F., A. Bertolotto, M. Olivero, P. Putzolu and T. Crepaldi et al., 1993. Selective expression of the Met/HGF receptor in human central nervous system microglia. Oncogenem, 8: 219-222.
    PubMed  |  
  230. Comoglio, P.M., 1993. Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells. EXS., 65: 131-165.
    PubMed  |  
  231. Buzzetti, F., M.G. Brasca, A. Crugnola, S. Fustinoni and A. Longo et al., 1993. Cinnamamide analogs as inhibitors of protein tyrosine kinases. Farmaco, 48: 615-636.
    PubMed  |  
  232. Saccone, S., R.P. Narsimhan, G. Gaudino, L. Dalpra, P.M. Comoglio and G. della Valle, 1992. Regional mapping of the human hepatocyte growth factor (HGF)-scatter factor gene to chromosome 7q21.1. Genomics, 13: 912-914.
    PubMed  |  
  233. Rege-Cambrin, G., P. Scaravaglio, F. Carozzi, S. Giordano, C. Ponzetto, P.M. Comoglio and G. Saglio, 1992. Karyotypic analysis of gastric carcinoma cell lines carrying an amplified c-met oncogene. Cancer Genet., 64: 170-173.
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  234. Naldini, L., L. Tamagnone, E. Vigna, M. Sachs and G. Hartmann et al., 1992. Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor. EMBO J., 11: 4825-4833.
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  235. Hartmann, G., L. Naldini, K.M. Weidner, M. Sachs, E. Vigna, P.M. Comoglio and W. Birchmeier, 1992. A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis. Proc. Natl. Acad. Sci., 89: 11574-11578.
    CrossRef  |  Direct Link  |  
  236. Giordano, S., M.F. di Renzo, M. Olivero, A. Mondino, Z. Zhen, E. Medico and P.M. Comoglio, 1992. The c-met/HGF receptor in human tumours. Eur. J. Cancer Prev., 1: 45-50.
    Direct Link  |  
  237. Bussolino, F., M.F. di Renzo, M. Ziche, E. Bocchietto and M. Olivero et al., 1992. Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J. Cell Biol., 119: 629-641.
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  238. Bardelli, A., F. Maina, I. Gout, M.J. Fry, M.D. Waterfield, P.M. Comoglio and C. Ponzetto, 1992. Autophosphorylation promotes complex formation of recombinant hepatocyte growth factor receptor with cytoplasmic effectors containing SH2 domains. Oncogene, 7: 1973-1978.
    PubMed  |  
  239. Prat, M., T. Crepaldi, L. Gandino, S. Giordano, P. Longati and P. Comoglio, 1991. C-terminal truncated forms of Met, the hepatocyte growth factor receptor. Mol. Cell. Biol., 11: 5954-5962.
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  240. Prat, M., R.P. Narsimhan, T. Crepaldi, M.R. Nicotra, P.G. Natali and P.M. Comoglio, 1991. The receptor encoded by the human C‐MET oncogene is expressed in hepatocytes, epithelial cells and solid tumors. Int. J. Cancer, 49: 323-328.
    CrossRef  |  Direct Link  |  
  241. Prat, M., M.F. Di Renzo, G. Gaudino, C. Ponzetto and P.M. Comoglio, 1991. Phosphotyrosine antibodies as probes for activated oncogene products endowed with tyrosine kinase activity. Ann. Ist Super Sanita, 27: 175-181.
    Direct Link  |  
  242. Ponzetto, C., S. Giordano, F. Peverali, G.D. Valle, M.L. Abate, G. Vaula and P.M. Comoglio, 1991. C-met is amplified but not mutated in a cell line with an activated met tyrosine kinase. Oncogene, 6: 553-559.
  243. Naldini, L., E. Vigna, R.P. Narsimhan, G. Gaudino, R. Zarnegar, G.K. Michalopoulos and P.M. Comoglio, 1991. Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET. Oncogene, 6: 501-504.
    Direct Link  |  
  244. Naldini, L., E. Vigna, R. Ferracini, P. Longati, L. Gandino, M. Prat and P.M. Comoglio, 1991. The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylation. Mol. Cell. Biol., 11: 1793-1803.
    CrossRef  |  Direct Link  |  
  245. Mondino, A., S. Giordano and P.M. Comoglio, 1991. Defective posttranslational processing activates the tyrosine kinase encoded by the MET proto-oncogene (hepatocyte growth factor receptor). Mol. Cell. Biol., 11: 6084-6092.
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  246. Lehtola, L., L. Sistonen, P. Koskinen, H. Lehvaslaiho, K. Alitalo, M.F.D. Renzo and P.M. Comoglio, 1991. Constitutively activated neu oncoprotein tyrosine kinase interferes with growth factor‐induced signals for gene activation. J. Cell. Biochem., 45: 69-81.
    CrossRef  |  Direct Link  |  
  247. Graziani, A., D. Gramaglia, L.C. Cantley and P.M. Comoglio, 1991. The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase. J. Biol. Chem., 266: 22087-22090.
    Direct Link  |  
  248. Gandino, L., L. Munaron, L. Naldini, R. Ferracini, M. Magni and P.M. Comoglio, 1991. Intracellular calcium regulates the tyrosine kinase receptor encoded by the MET oncogene. J. Biol. Chem., 266: 16098-16104.
    Direct Link  |  
  249. Ferracini, R., P. Longati, L. Naldini, E. Vigna and P.M. Comoglio, 1991. Identification of the major autophosphorylation site of the Met/hepatocyte growth factor receptor tyrosine kinase. J. Biol. Chem., 266: 19558-19564.
    Direct Link  |  
  250. Di, M.R., R.P. Narsimhan, M. Olivero, S. Bretti and S. Giordano et al., 1991. Expression of the Met/HGF receptor in normal and neoplastic human tissues. Oncogene, 6: 1997-2003.
    Direct Link  |  
  251. Sturani, E., R. Zippel, L. Morello, R. Brambilla, P.M. Comoglio and L. Alberghina, 1990. Kinetics of tyrosine phosphorylation and internalization of human EGF receptors overexpressed in NIH 3T3 fibroblasts. Exp. Cell Res., 191: 323-327.
    CrossRef  |  Direct Link  |  
  252. Naldini, L., D. Cirillo, T.W. Moody, P.M. Comoglio, J. Schlessinger and R. Kris, 1990. Solubilization of the receptor for the neuropeptide gastrin-releasing peptide (bombesin) with functional ligand binding properties. Biochemistry, 29: 5153-5160.
    CrossRef  |  Direct Link  |  
  253. Lehvaslaiho, H., L. Sistonen, M.F. Di Renzo, J. Partanen, P. Comoglio, E. Holtta and K. Alitalo, 1990. Regulation by EGF is maintained in an overexpressed chimeric EGFR/neu receptor tyrosine kinase. J. Cell. Biochem., 42: 123-133.
    CrossRef  |  Direct Link  |  
  254. Gandino, L., M.F. Di Renzo, S. Giordano, F. Bussolino and P.M. Comoglio, 1990. Protein kinase-c activation inhibits tyrosine phosphorylation of the c-met protein. Oncogene, 5: 721-725.
    Direct Link  |  
  255. De, R.C., L. Gozzini, R. Mena, M. Brugnolotti and M. Ciomei et al., 1990. Bombesin receptor antagonists [corrected]. 1. Analogues with deleted, inverted or substituted amino acid residues. Farmaco, 45: 1251-1263.
    Direct Link  |  
  256. Comoglio, P.M., M.F.D. Renzo, G. Gaudino, C. Ponzetto and M. Prat, 1990. Tyrosine kinase and control of cell proliferation. Am. Rev. Respiratory Dis. Fifth, 142: S16-S19.
    CrossRef  |  Direct Link  |  
  257. Cirillo, D., L. Naldini, T.W. Moody, P. Comoglio, J. Schlessinger and R. Kris, 1990. Characterization of the detergent solubilized receptor for gastrin-releasing peptide. Peptides, 11: 737-745.
    CrossRef  |  Direct Link  |  
  258. Bretti, S., A.P. Cappa, P.M. Comoglio and M.R. Di, 1990. Tyrosine-phosphorylated proteins in human breast carcinoma. J. Nuclear Med. Allied Sci., 34: 205-210.
    Direct Link  |  
  259. Zippel, R., L. Morello, R. Brambilla, P.M. Comoglio, L. Alberghina and E. Sturani, 1989. Inhibition of phosphotyrosine phosphatases reveals candidate substrates of the PDGF receptor kinase. Eur. J. Cell Biol., 50: 428-434.
    Direct Link  |  
  260. Prat, M., E. Medico, P. Rossino, C. Garrino and P.M. Comoglio, 1989. Biochemical and immunological properties of the human carcinoma-associated CAR-3 epitope defined by the monoclonal antibody AR-3. Cancer Res., 49: 1415-1421.
    Direct Link  |  
  261. Prat, M., E. Medico, C. Garrino and P.M. Comoglio, 1989. Biochemical and immunological properties of the human carcinoma antigen car‐5 defined by the monoclonal antibody BD‐5. Int. J. Cancer, 44: 67-74.
    CrossRef  |  Direct Link  |  
  262. King, C.R., I. Borrello, L. Porter, P. Comoglio and J. Schlessinger, 1989. Ligand-independent tyrosine phosphorylation of EGF receptor and the erbB-2/neu proto-oncogene product is induced by hyperosmotic shock. Oncogene, 4: 13-18.
    Direct Link  |  
  263. Giordano, S., M.F. Di Renzo, R.P. Narsimhan, C.S. Cooper, C. Rosa and P.M. Comoglio, 1989. Biosynthesis of the protein encoded by the c-met proto-oncogene. Oncogene, 4: 1383-1388.
  264. Giordano, S., C. Ponzetto, M.F. Di Renzo, C.S. Cooper and P.M. Comoglio, 1989. Tyrosine kinase receptor indistinguishable from the c-met protein. Nature, 339: 155-156.
    CrossRef  |  Direct Link  |  
  265. Comoglio, P.M., 1989. Growth factor receptors and class 1 oncogenes in cancer. Anim. Genet., 20: 348-350.
    CrossRef  |  Direct Link  |  
  266. Calorini, L., A. Fallani, D. Tombaccini, E. Barletta and G. Mugnai et al., 1989. Lipid characteristics of RSV-transformed Balb/c 3T3 cell lines with different spontaneous metastatic potentials. Lipids, 24: 685-690.
    CrossRef  |  Direct Link  |  
  267. Brusa, P., F. Pietribiasi, G. Bussolati, F. Dosio and R. Arione et al., 1989. Blocked and not blocked whole-ricin-antibody immunotoxins: Intraperitoneal therapy of human tumour xenografted in nude mice. Cancer Immunol. Immunotherapy, 29: 185-192.
    CrossRef  |  Direct Link  |  
  268. Bretti, S., P. Neri, L. Lozzi, M. Rustici, P. Comojlio, F. Giancotti and G. Tarone, 1989. Inhibition of experimental metastasis of murine fibrosarcoma cells by oligopeptide analogues to the fibronectin cell‐binding site. Int. J. Cancer, 43: 102-106.
    CrossRef  |  Direct Link  |  
  269. Zippel, R., L. Morello, L. Toschi, L. Alberghina, P.M. Comoglio and E. Sturani, 1988. Effect of the growth conditions on the expression of cell-surface-associated platelet-derived growth factor receptors in mouse fibroblasts. Biochimica et Biophysica Acta (BBA)-Bioenergetics, 971: 351-357.
    CrossRef  |  Direct Link  |  
  270. Sturani, E., R. Zippel, L. Toschi, L. Morello, P.M. Comoglio and L. Alberghina, 1988. Kinetics and regulation of the tyrosine phosphorylation of epidermal growth factor receptor in intact A431 cells. Mol. Cell. Biol., 8: 1345-1351.
    CrossRef  |  Direct Link  |  
  271. Prat, M., E. Medico, P. Piantino, S. Bretti, F.P. Rossini and P.M. Comoglio, 1988. The monoclonal antibody-defined CAR-3 antigen is a serological marker associated with pancreatic carcinoma. Int. J. Biol. Markers, 3: 29-35.
    Direct Link  |  
  272. Marchisio, P.C., N. D'Urso, P.M. Comoglio, F.G. Giancotti and G. Tarone, 1988. Vanadate‐treated baby hamster kidney fibroblasts show cytoskeleton and adhesion patterns similar to their rous sarcoma virus‐transformed counterparts. J. Cell. Biochem., 37: 151-159.
    CrossRef  |  Direct Link  |  
  273. King, C.R., I. Borrello, F. Bellot, P. Comoglio and J. Schlessinger, 1988. Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB‐2 protein in the mammary tumor cell line SK‐BR‐3. EMBO J., 7: 1647-1651.
    CrossRef  |  Direct Link  |  
  274. Giordano, S., M.F. Di Renzo, R.P. Narsimhan, L. Tamagnone, E.V. Gerbaudo, L. Chiado‐Piat and P.M. Comoglio, 1988. Evidence for autocrine activation of a tyrosine kinase in a human gastric carcinoma cell line. J. Cell. Biochem., 38: 229-236.
    CrossRef  |  Direct Link  |  
  275. Giordano, S., M.F. Di Renzo, R. Ferracini, L. Chiado-Piat and P.M. Comoglio, 1988. p145, a protein with associated tyrosine kinase activity in a human gastric carcinoma cell line. Mol. Cell. Biol., 8: 3510-3517.
    CrossRef  |  Direct Link  |  
  276. Gaudino, G., M. Cilli, L. Gandino, P. Rossino, A. Mondino and P.M. Comoglio, 1988. A tyrosine protein kinase activated by bombesin in normal fibroblasts and small cell carcinomas. Ann. N. Y. Acad. Sci., 547: 293-302.
    CrossRef  |  Direct Link  |  
  277. Gaudino, G., D. Cirillo, L. Naldini, P. Rossino and P.M. Comoglio, 1988. Activation of the protein-tyrosine kinase associated with the bombesin receptor complex in small cell lung carcinomas. Proc. Nat. Acad. Sci., 85: 2166-2170.
    CrossRef  |  Direct Link  |  
  278. Comoglio, P.M., M.F. Di Renzo, R. Ferracini, G. Gaudino and S. Giordano, 1988. Detection of deregulated tyrosine-kinases in experimental and human metastatic tumors. Adv. Exp. Med. Biol., 233: 303-308.
    Direct Link  |  
  279. Cattel, L., L. Delprino, P. Brusa, F. Dosio, P.M. Comoglio and M. Prat, 1988. Comparison of blocked and non-blocked ricin-antibody immunotoxins against human gastric carcinoma and colorectal adenocarcinoma cell lines. Cancer Immunol. Immunotherapy, 27: 233-240.
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  280. Allavena, G., A. Melchiori, S. Carlone, M.F. Di Renzo and P. Comoglio et al., 1988. High chemotactic motility and growth in hard agar of a variant of RSV-transformed fibroblasts are lost in late passages. Tumori J., 74: 1-6.
    CrossRef  |  Direct Link  |  
  281. Underhill, C.B., S.J. Green, P.M. Comoglio and G. Tarone, 1987. The hyaluronate receptor is identical to a glycoprotein of Mr 85,000 (gp85) as shown by a monoclonal antibody that interferes with binding activity. J. Biol. Chem., 262: 13142-13146.
    Direct Link  |  
  282. Prat, M., S. Bretti, M. Amedeo, S. Landolfo and P.M. Comoglio, 1987. Monoclonal antibodies against murine IFN-gamma abrogate in vivo tumor immunity against RSV-induced murine sarcomas. J. Immunol., 138: 4530-4533.
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  283. Prat, M., P. Rossino, G. Bussolati, I. Morra and P.M. Comoglio, 1987. Production of monoclonal antibodies for the immunohistochemical detection of gastric carcinomas. Cancer Detection Prevention, 10: 293-301.
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  284. Prat, M., B. Griselli, A. Bernardi, P. Rossino, G.L. Candelaresi, A.P. Cappa and P.M. Comoglio, 1987. Expression of the monoclonal antibody-defined CAR-3 epitope on neoplastic and preneoplastic lesions of the colon mucosa. Eur. J. Cancer Clin. Oncol., 23: 923-932.
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  285. Gribaudo, G., M.F. Di Renzo, L. Naldini, P.M. Comoglio, G. Cavallo and S. Landolfo, 1987. Interferon-gamma inhibits cell replication, but not pp60src activity of RSV-transformed fibroblasts. Microbiologica, 10: 47-53.
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  286. Giordano, S., M.F. Di Renzo, D. Cirillo, L. Naldini, L.C. Piat and P.M. Comoglio, 1987. Proteins phosphorylated on tyrosine as markers of human tumor cell lines. Int. J. Cancer, 39: 482-487.
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  287. Giancotti, F.G., P.M. Comoglio and G. Tarone, 1987. Interaction of fibroblasts, hemopoietic cells and platelets with extracellular matrix: Characterization and role of a common cell surface glycoprotein. Ann. N. Y. Acad. Sci., 511: 65-76.
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  288. Comoglio, P.M., M.F. Renzo and G. Gaudino, 1987. Protein tyrosine kinases associated with human malignancies. Ann. N. Y. Acad. Sci., 511: 256-261.
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  289. Albini, A., G. Allavena, A. Melchiori, F. Giancotti and H. Richter et al., 1987. Chemotaxis of 3T3 and SV3T3 cells to fibronectin is mediated through the cell-attachment site in fibronectin and a fibronectin cell surface receptor. J. Cell Biol., 105: 1867-1872.
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  290. Zippel, R., E. Sturani, L. Toschi, L. Naldini, L. Alberghina and P.M. Comoglio, 1986. In vivo phosphorylation and dephosphorylation of the platelet-derived growth factor receptor studied by immunoblot analysis with phosphotyrosine antibodies. Biochimica et Biophysica Acta (BBA)-General Subjects, 881: 54-61.
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  291. Sturani, E., L.M. Vicentini, R. Zippel, L. Toschi, A. Pandiella-Alonso, P.M. Comoglio and J. Meldolesi, 1986. PDGF-induced receptor phosphorylation and phosphoinositide hydrolysis are unaffected by protein kinase C activation in mouse Swiss 3T3 and human skin fibroblasts. Biochem. Biophys. Res. Commun., 137: 343-350.
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  292. Saggioro, D., R. Ferracini, M.F. Di Renzo, L. Naldini, L. Chieco‐Bianchi and P.M. Comoglio, 1986. Protein phosphorylation at tyrosine residues IN v‐abl transformed mouse lymphocytes and fibroblasts. Int. J. Cancer, 37: 623-628.
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  293. Prat, M., G.C. Corbascio, P. Rossino, F. Tusco, P.M. Comoglio and P.C. Marchisio, 1986. Production of a monoclonal antibody reacting with vimentin, a structural protein of intermediate filaments. Basic Applied Histochem., 30: 417-424.
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  294. Palumbo, A.P., P. Rossino and P.M. Comoglio, 1986. Bombesin stimulation of c-fos and c-myc gene expression in cultures of Swiss 3T3 cells. Exp. Cell Res., 167: 276-280.
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  295. Naldini, L., A. Stacchini, D.M. Cirillo, M. Aglietta, F. Gavosto and P.M. Comoglio, 1986. Phosphotyrosine antibodies identify the p210c-abl tyrosine kinase and proteins phosphorylated on tyrosine in human chronic myelogenous leukemia cells. Mol. Cell. Biol., 6: 1803-1811.
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  296. Giancotti, F.G., P.M. Comoglio and G. Tarone, 1986. Fibronectin-plasma membrane interaction in the adhesion of hemopoietic cells. J. Cell Biol., 103: 429-437.
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  297. Giancotti, F.G., P.M. Comoglio and G. Tarone, 1986. A 135000 molecular weight plasma membrane glycoprotein involved in fibronectin-mediated cell adhesion: Immunofluorescence localization in normal and RSV-transformed fibroblasts. Exp. Cell Res., 163: 47-62.
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  298. Di Renzo, M.F., R. Ferracini, L. Naldini, S. Giordano and P.M. Comoglio, 1986. Immunological detection of proteins phosphorylated at tyrosine in cells stimulated by growth factors or transformed by retroviral‐oncogene‐coded tyrosine kinases. FEBS J., 158: 383-391.
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  299. Cirillo, D.M., G. Gaudino, L. Naldini and P.M. Comoglio, 1986. Receptor for bombesin with associated tyrosine kinase activity. Mol. Cell. Biol., 6: 4641-4649.
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  300. Tarone, G., D. Cirillo, F.G. Giancotti, P.M. Comoglio and P.C. Marchisio, 1985. Rous sarcoma virus-transformed fibroblasts adhere primarily at discrete protrusions of the ventral membrane called podosomes. Exp. Cell Res., 159: 141-157.
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  301. Saggioro, D., M.F. Di Renzo, P.M. Comoglio and L. Chieco-Bianchih, 1985. Different cellular substrates of Abelson leukemia virus transforming protein kinase in murine fibroblasts and lymphocytes. Haematol Blood Transfus, 29: 298-301.
  302. Prat, M., I. Morra, G. Bussolati and P.M. Comoglio, 1985. CAR-3, a monoclonal antibody-defined antigen expressed on human carcinomas. Cancer Res., 45: 5799-5807.
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  303. Prat, M., G. Bussolati, M.R. Spinnato and P.M. Comoglio, 1985. Monoclonal antibodies against the human epidermoid carcinoma A 431. Cancer Detection Prevention, 8: 169-179.
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  304. Giancotti, F.G., G. Tarone, K. Knudsen, C. Damsky and P.M. Comoglio, 1985. Cleavage of a 135 kD cell surface glycoprotein correlates with loss of fibroblast adhesion to fibronectin. Exp. Cell Res., 156: 182-190.
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  305. Fischer, S., R. Fagard, P. Comoglio and G. Gacon, 1985. Phosphoinositides are not phosphorylated by the very active tyrosine protein kinase from the murine lymphoma LSTRA. Biochem. Biophys. Res. Commun., 132: 481-489.
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  306. Doneda, L., M.F. Di Renzo, P.M. Comoglio and L. Larizza, 1985. Role of heterochromatin variation in the instability of a marker chromosome during tumor progression. Cancer Genet. Cytogenetics, 15: 283-291.
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  307. Di Renzo, M.F., G. Tarone, P.M. Comoglio and P.C. Marchisio, 1985. Organization of cytoskeleton and fibronectin matrix in Rous Sarcoma Virus (RSV)-transformed fibroblast lines with different metastatic potential. Eur. J. Cancer Clin. Oncol., 21: 85-96.
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  308. Comoglio, P.M., M. Prat and S. Bretti, 1985. Enhancement of immunity against RSV-induced sarcomas by generation of hapten-reactive helper T lymphocytes. Immunology, 54: 289-295.
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  309. Tarone, G., R. Ferracini, G. Galetto and P. Comoglio, 1984. A cell surface integral membrane glycoprotein of 85,000 mol wt (gp85) associated with triton X-100-insoluble cell skeleton. J. Cell Biol., 99: 512-519.
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  310. Tarone, G., M.R. Amedeo, M.F. Di Renzo and P. Comoglio, 1984. Monoclonal antibodies to the collagen binding domain of human plasma fibronectin. Pathobiology, 52: 225-236.
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  311. Prat, M., G. Gribaudo, P.M. Comoglio, G. Cavallo and S. Landolfo, 1984. Monoclonal antibodies against murine gamma interferon. Proc. Nat. Acad. Sci., 81: 4515-4519.
    CrossRef  |  Direct Link  |  
  312. Marchisio, P.C., M.F. Di Renzo and P.M. Comoglio, 1984. Immunofluorescence localization of phosphotyrosine containing proteins in RSV-transformed mouse fibroblasts. Exp. Cell Res., 154: 112-124.
    CrossRef  |  Direct Link  |  
  313. Gacon, G., R. Fagard, J.P. Boissel, S. Fischer and L. Reibel et al., 1984. Identification of a 58,000 daltons phosphoprotein with tyrosine protein kinase activity in a murine lymphoma cell line. Biochem. Biophys. Res. Commun., 122: 563-570.
    CrossRef  |  Direct Link  |  
  314. Comoglio, P.M., M.F. Di Renzo, G. Tarone, F.G. Giancotti, L. Naldini and P.C. Marchisio, 1984. Detection of phosphotyrosine‐containing proteins in the detergent‐insoluble fraction of RSV‐transformed fibroblasts by azobenzene phosphonate antibodies. EMBO J., 3: 483-489.
    CrossRef  |  Direct Link  |  
  315. Cofano, F., P.M. Comoglio, S. Landolfo and G. Tarone, 1984. Mouse immune interferon enhances fibronectin production of elicited macrophages. J. Immunol., 133: 3102-3106.
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  316. Cirillo, D., P.M. Comoglio, L. Naldini, P.C. Marchisio and I.P. Ronchetti, 1984. Visualization of phosphotyrosine containing molecules within the detergent insoluble cell matrix of v-src transformed fibroblasts. Cell Biol. Int. Rep., 8: 959-969.
    CrossRef  |  Direct Link  |  
  317. Prat, M., M.F. Di Renzo and P.M. Comoglio, 1983. Characterization of T lymphocytes mediating in vivo protection against RSV‐induced murine sarcomas. Int. J. Cancer, 31: 757-764.
    CrossRef  |  Direct Link  |  
  318. Di Renzo, M.F., L. Doneda, L. Larizza and P.M. Comoglio, 1983. Metastatic clones selected from an RSV‐induced mouse sarcoma share a common marker chromosome. Int. J. Cancer, 31: 455-461.
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  319. Tarone, G., G. Galetto, M. Prat and P.M. Comoglio, 1982. Cell surface molecules and fibronectin-mediated cell adhesion: Effect of proteolytic digestion of membrane proteins. J. Cell Biol., 94: 179-186.
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  320. Ferracini, R., M. Prat and P.M. Comoglio, 1982. Dissection of the antigenic determinants expressed on the cell surface of rsv‐transformed fibroblasts by monoclonal antibodies. Int. J. Cancer, 29: 477-481.
    CrossRef  |  Direct Link  |  
  321. Bertini, M., G. Galetto and P.M. Comoglio, 1982. Immune complexes and circulating antibodies against autologous leukaemic cells in patients with acute leukaemias. Immunology, 45: 569-575.
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  322. Tarone, G., P. Ceschi, M. Prat and P.M. Comoglio, 1981. Transformation-sensitive protein with molecular weight of 45,000 secreted by mouse fibroblasts. Cancer Res., 41: 3648-3652.
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  323. Prat, M., G. Tarone and P.M. Comoglio, 1981. Mouse fibroblasts transformed by rous sarcoma virus express a virus‐specific non‐virion transplantation antigen. Int. J. Cancer, 27: 797-805.
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  324. Tarone, G., M. Prat and P.M. Comoglio, 1980. Identification and partial characterization of five major membrane glycoproteins of BHK fibroblasts. J. Membrane Biol., 53: 55-61.
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  325. Prat, M., F. Tato, G. Tarone and P.M. Comoglio, 1980. Target antigens for antibodies and complement at the cell surface of RSV-transformed fibroblasts. Immunology, 39: 179-185.
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  326. Prat, M., F. Tato, G. Tarone and P.M. Comoglio, 1980. Interaction between cellular and viral genes in the expression of the RSV‐induced transformation‐specific cell‐surface antigen VCSA. Int. J. Cancer, 25: 355-362.
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  327. Sartore, S., G. Tarone, M. Cantini, S. Schiaffino and P.M. Comoglio, 1979. Cell surface changes during muscle differentiation in vitro: A study with the probe 2, 4, 6-trinitrobenzene sulphonate. Cell Differentiation, 8: 1-9.
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  328. Comoglio, P.M., B. Pani, M. Prat, G. Tarone and C. Monti-Bragadin, 1979. Relationship between Rous sarcoma virus-induced expression of membrane antigen and phenotypic transformation. Cancer Res., 39: 4744-4748.
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  329. Comoglio, P.M., M. Prat and M. Bertini, 1978. A virus-induced non-virion antigen specific for transformation at the surface of RSV-transformed fibroblasts. Nature, 273: 381-383.
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  330. Comoglio, P.M., M. Bertini and M. Prat, 1978. Tumor‐specific and tumor‐associated membrane antigens of rous sarcoma virus transformed hamster fibroblasts. Int. J. Cancer, 22: 55-62.
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  331. Comoglio, P.M., G. Tarone and M. Bertini, 1978. Immunochemical purification of probe‐labeled plasma membrane proteins: An approach to the molecular anatomy of the cell surface. J. Cell. Biochem., 8: 39-49.
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  332. Tarone, G. and P.M. Comoglio, 1977. Plasma membrane proteins exposed on the outer surface of control and Rous sarcoma virus-transformed hamster fibroblasts. Exp. Cell Res., 110: 143-152.
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  333. Comoglio, P.M., G. Tarone, M. Bertini and M. Prat, 1977. Structure of the cell membrane and tumor antigens of the cell surface of BHK fibroblasts transformed by RSV (proceedings). Minerva Med., 68: 3533-3534.
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  334. Bertini, M., C. Marinone, M. Giovarelli and P.M. Comoglio, 1977. Primary humoral immune response against tumor membrane antigens and foreign antigens by plasma cell tumor bearer mice. Giornale di batteriol. Virol. Ed Immunol., 70: 144-156.
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  335. Tarone, G. and P.M. Comoglio, 1976. Binding of serum polypeptides to the plasma membrane outer surface. FEBS Lett., 67: 364-367.
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  336. Prat, M. and P.M. Comoglio, 1976. Involvement of sialic acids in the immunological specificity of plasma membrane glycoproteins. Immunochemistry, 13: 97-102.
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  337. Prat, M. and P.M. Comoglio, 1976. A solid-state competitive binding radioimmunoassay for measurement of antigens solubilized from membranes. J. Immunol. Methods, 9: 267-272.
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  338. Giovarelli, M., P.M. Comoglio and G. Forni, 1976. Induction of resistance or enhancement to a transplantable murine plasmacytoma by transfer of non-immune leucocytes. Br. J. Cancer, 34: 233-238.
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  339. Comoglio, P.M. and G. Forni, 1976. Molecular basis of the immunogenicity of cell surface tumor antigens. Pathobiology, 44: 150-169.
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  340. Prat, M., S. Landolfo and P.M. Comoglio, 1975. Neuraminidase sensitive antigenic determinants of plasma cell tumor membrane glycoproteins. FEBS Lett., 51: 351-354.
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  341. Prat, M., G. Tarone and P.M. Comoglio, 1975. Antigenic and immunogenic properties of membrane proteins solubilized by sodium desoxycholate, papain digestion or high ionic strength. Immunochemistry, 12: 9-17.
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  342. Comoglio, P.M., M. Bertini and G. Forni, 1975. Evidence for a membrane carrier molecule common to embryonal and tumour-specific antigenic determinants expressed by a mouse transplantable tumour. Immunology, 29: 353-364.
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  343. Comoglio, P.M., G. Tarone, M. Prat and M. Bertini, 1975. Studies on the outer surface of normal and RSV-transformed BHK fibroblast plasma membrane. Exp. Cell Res., 93: 402-410.
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  344. Vidal, R., G. Tarone, F. Peroni and P.M. Comoglio, 1974. A comparative study of SV40‐transformed fibroblast plasma membrane proteins labelled by enzymatic iodination or with trinitrobenzene sulfonate. FEBS Lett., 47: 107-112.
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  345. Forni, G. and P.M. Comoglio, 1974. Effect of solubilized membrane antigens and tumour bearer serum on tumour growth in syngeneic hosts. Br. J. Cancer, 30: 365-369.
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  346. Bertini, M., G. Forni and P.M. Comoglio, 1974. A tumour-associated membrane antigen transiently expressed by normal cells during mitosis. Clin. Exp. Immunol., 18: 101-108.
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  347. Tarone, G., M. Prat and P.M. Comoglio, 1973. Affinity chromatography purification of erythrocyte membrane proteins after selective labeling with trinitrobenzene sodium sulfonate. Biochimica et Biophysica Acta (BBA)-Biomembranes, 311: 214-221.
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  348. Forni, G. and P.M. Comoglio, 1973. Growth of syngeneic tumours in unimmunized newborn and adult hosts. Br. J. Cancer, 27: 120-127.
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  349. Comoglio, P.M. and R. Guglielmone, 1973. Immunohistochemical study of IgA transepithelial transfer into digestive tract secretions in the mouse. Immunology, 25: 71-80.
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  350. Comoglio, P.M. and G. Forni, 1973. Plasma‐cell and tumor‐associated membrane antigens of mouse plasmacytoma MOPC‐315 and MOPC‐460. Int. J. Cancer, 12: 613-625.
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  351. Comoglio, P.M. and G. Filogamo, 1973. Plasma membrane fluidity and surface motility of mouse C-1300 neuroblastoma cells. J. Cell Sci., 13: 415-420.
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  352. Comoglio, P.M. and R. Guglielmone, 1972. Two dimensional distribution of concanavalin‐A receptor molecules on fibroblast and lymphocyte plasma membranes. FEBS Lett., 27: 256-258.
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  353. Comoglio, P., 1972. Antigen-dependent mast cell differentiation in vitro. Exp. Cell Res., 72: 404-408.
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  354. Comoglio, P.M., G. Ottino and D. Cantino, 1971. Experimental study on development and behaviour of the multinucleated giant cells' in vitro'. J. Reticuloendothelial Soc., 9: 397-408.
  355. Comoglio, P.M., 1971. Immunochemical structure of the plasmatic membrane of transformed cells. Giornale Batteriol. Virol. Immunol., 64: 397-410.
  356. Comoglio, P.M. and G.M. Ottino, 1971. Morphological and biochemical changes of rat prostate organ cultures and their reaction to prostate extracts. Life Sci. Part 2, 10: 325-331.
  357. Comoglio, P.M. and G.M. Ottino, 1971. In vitro kinetics of embryonic spleen cells. Minerva Pediatrica, 23: 188-189.
  358. Ottino, G.M. and P.M. Comoglio, 1970. [Simple method for culture of lymphatic organs]. C R Assoc. Anat., 149: 945-950.
    PubMed  |  Direct Link  |  
  359. Comoglio, P.M., 1970. Affinity constant of anti-DNP secretory IgA. Giornale Batteriol. Virol. Immunol., 63: 739-743.
  360. Comoglio, P.M., D. Cantino and G.M. Ottino, 1969. Multinucleated giant cells in organ cultures of spleen. Experientia, 25: 61-62.
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  361. Comoglio, P. and G. Ottino, 1967. Action of phytohemagglutinin on the embryonal spleen in organotypic culture. Boll. Soc. Ital Biol. Sper., 43: 1162-1164.
  362. Cantino, D. and P. Comoglio, 1966. [The distribution of motor plates in the mimic muscles of the dog (Canis familiaris L.)]. Boll. Soc. Ital Biol. Sper., 42: 1201-1203.
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