Prof. Claudia  Martini

Prof. Claudia Martini

Professor
University of Pisa, Italy


Highest Degree
Ph.D. in Biochemistry from University of Pisa, Italy

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Area of Interest:

Biomedical Sciences
100%
Biochemistry
62%
Receptors
90%
Neurodegenaration
75%
Cancer
55%

Selected Publications

  1. Trincavelli, M.L., E. Da Pozzo, O. Ciampi, S. Cuboni, S. Daniele, M.P. Abbracchio and C. Martini, 2013. Regulation of erythropoietin receptor activity in endothelial cells by different Erythropoietin (EPO) derivatives: An in vitro study. Int. J. Mol. Sci., 14: 2258-2281.
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  2. Taliani, S., M.L. Trincavelli, B. Cosimelli, S. Laneri and E. Severi et al., 2013. Modulation of A2B adenosine receptor by 1-benzyl-3-ketoindole derivatives. Eur. J. Med. Chem., 69: 331-337.
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  3. Raccosta, L., R. Fontana, D. Maggioni, C. Lanterna and E.J. Villablanca et al., 2013. The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils. J. Exp. Med., 210: 1711-1728.
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  4. Martini, C., E. Da Pozzo, C. Carmassi, S. Cuboni and M.L. Trincavelli et al., 2013. Cyclic adenosine monophosphate responsive element binding protein in post-traumatic stress disorder. World J. Biol. Psychiatry, 14: 396-402.
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  5. Luykx, J.J., M.P.M. Boks, E.J. Breetvelt, M.F. Aukes and E. Strengman et al., 2013. BDNF Val66Met homozygosity does not influence plasma BDNF levels in healthy human subjects. Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 43: 185-187.
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  6. La Regina, G., R. Bai, W.M. Rensen, E. Di Cesare and A. Coluccia et al., 2013. Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors. J. Med. Chem., 56: 123-149.
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  7. Fogli, S., F. Stefanelli, A. Martelli, S. Daniele and L. Testai et al., 2013. Protective effect of high-dose montelukast on salbutamol-induced homologous desensitisation in airway smooth muscle. Pulmonary Pharmacol. Ther., 26: 693-699.
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  8. Costa, B., S. Bendinelli, P. Gabelloni, E. Da Pozzo and S. Daniele et al., 2013. Human glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor. PLoS ONE, Vol. 8. 10.1371/journal.pone.0072281.
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  9. Costa, B., A.F. Grillone, A. Salvetti, S. Rocchiccioli and P. Iacopetti et al., 2013. An antibody-free strategy for screening putative HDM2 inhibitors using crude bacterial lysates expressing GST-HDM2 recombinant protein. Drug Testing Anal., 5: 596-601.
    CrossRef  |  Direct Link  |  

  10. Trincavelli, M.L., S. Daniele, E. Orlandini, G. Navarro and V. Casado et al., 2012. A new D2 dopamine receptor agonist allosterically modulates A2A adenosine receptor signalling by interacting with the A2A/D2 receptor heteromer. Cell. Signall., 24: 951-960.
    CrossRef  |  

  11. Trincavelli, M.L., E. Da Pozzo, S. Daniele and C. Martini, 2012. The GABAA-BZR complex as target for the development of anxiolytic drugs. Curr. Top. Med. Chem., 12: 254-269.
    CrossRef  |  

  12. Taliani, S., I. Pugliesi, E. Barresi, F. Simorini and S. Salerno et al., 2012. 3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: A novel template for the design of highly selective A2B adenosine receptor antagonists. J. Med. Chem., 55: 1490-1499.
    CrossRef  |  Direct Link  |  

  13. Simoni, E., S. Daniele, G. Bottegoni, D. Pizzirani and M.L. Trincavelli et al., 2012. Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease. J. Med. Chem., 55: 9708-9721.
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  14. Scarf, A.M., C. Luus, E. Da Pozzo, S. Selleri and C. Guarino et al., 2012. Evidence for complex binding profiles and species differences at the Translocator Protein (TSPO) (18 kDa). Curr. Mol. Med., 12: 488-493.
    CrossRef  |  

  15. Maggio, B., D. Raffa, M.V. Raimondi, F. Plescia and M.L. Trincavelli et al., 2012. Synthesis, benzodiazepine receptor binding and molecular modelling of isochromeno[4,3-c]pyrazol-5(1H)-one derivatives. Eur. J. Med. Chem., 54: 709-720.
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  16. Graziano, A., M.P. Giovannoni, A. Cilibrizzi, L. Crocetti and V.D. Piaz et al., 2012. New pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones fluoroderivatives as human A1 adenosine receptor ligands. Acta Chimica Slovenica, 59: 648-655.
    PubMed  |  

  17. Giorgioni, G., D. Ambrosini, G.F. Palmieri, B. Costa, A. Di Stefano and C. Martini, 2012. Synthesis of novel 4-aryl-1,2,3,4-tetrahydroisoquinolines as probes for dopamine receptor ligands. Med. Chem., 8: 699-704.
    CrossRef  |  

  18. Dell'Osso, L., D. Marazziti, E. Da Pozzo, C. Conversano and S. Baroni et al., 2012. Gender effect on the relationship between stress hormones and panic-agoraphobic spectrum dimensions in healthy subjects. CNS Spectrums, 17: 214-220.
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  19. Daniele, S., E. Da Pozzo, M. Abelli, A. Panighini and S. Pini et al., 2012. Platelet uptake of GABA and glutamate in patients with bipolar disorder. Bipolar Disorders, 14: 301-308.
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  20. Da Pozzo, E., M.C. Barsotti, S. Bendinelli, A. Martelli and V. Calderone et al., 2012. Differential effects of fondaparinux and bemiparin on angiogenic and vasculogenesis-like processes. Thrombosis Res., 130: e113-e122.
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  21. Da Pozzo, E., B. Costa and C. Martini, 2012. Translocator Protein (TSPO) and neurosteroids: Implications in psychiatric disorders. Curr. Mol. Med., 12: 426-442.
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  22. Costa, B., S. Pini, M. Abelli, P. Gabelloni and E. Da Pozzo et al., 2012. Role of translocator protein (18 kDa) in adult separation anxiety and attachment style in patients with depression. Curr. Mol. Med., 12: 483-487.
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  23. Costa, B., E. Da Pozzo and C. Martini, 2012. Translocator protein as a promising target for novel anxiolytics. Curr. Top. Med. Chem., 12: 270-285.
    CrossRef  |  

  24. Castellano, S., S. Taliani, C. Milite, I. Pugliesi and E. Da Pozzo et al., 2012. Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein. J. Med. Chem., 55: 4506-4510.
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  25. Asteriti, S., S. Daniele, F. Porchia, M.T. Dell'anno and A. Fazzini et al., 2012. Modulation of PAR1 signalling by benzimidazole compounds. Br. J. Pharmacol., 167: 80-94.
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  26. Tuccinardi, T., A.T. Zizzari, C. Brullo, S. Daniele and F. Musumeci et al., 2011. Substituted pyrazolo[3,4-b]pyridines as human A1 adenosine antagonists: Developments in understanding the receptor stereoselectivity. Org. Biomol. Chem., 9: 4448-4455.
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  27. Scatena, A., F. Fornai, M.L. Trincavelli, S. Taliani and S. Daniele et al., 2011. 3-(Fur-2-yl)-10-(2-phenylethyl)-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one, a novel adenosine receptor antagonist with A2A-mediated neuroprotective effects. ACS Chem. Neurosci., 2: 526-535.
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  28. Poli, D., D. Catarzi, V. Colotta, F. Varano and G. Filacchioni et al., 2011. The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists. J. Med. Chem., 54: 2102-2113.
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  29. Pike, V.W., S. Taliani, T.G. Lohith, D.R. Owen and I. Pugliesi et al., 2011. Evaluation of novel N1-methyl-2-phenylindol-3-ylglyoxylamides as a new chemotype of 18 kDa translocator protein-selective ligand suitable for the development of positron emission tomography radioligands. J. Med. Chem., 54: 366-373.
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  30. Nuti, E., F. Casalini, S. Santamaria, P. Gabelloni and S. Bendinelli et al., 2011. Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors. Eur. J. Med. Chem., 46: 2617-2629.
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  31. Martini, C., S. Daniele, M. Picchetti, A. Panighini and M. Carlini et al., 2011. A2A adenosine receptor binding parameters in platelets from patients affected by pathological gambling. Neuropsychobiology, 63: 154-159.
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  32. Guerrini, G., G. Ciciani, F. Bruni, S. Selleri and F. Melani et al., 2011. New 3-, 8-disubstituted pyrazolo[5,1-c][1,2,4]benzotriazines useful for studying the interaction with the HBp-3 area (hydrogen bond point area) in the benzodiazepine site on the γ-aminobutyric acid type A (GABAA) receptor. Bioorg. Med. Chem., 19: 3074-3085.
    CrossRef  |  PubMed  |  Direct Link  |  

  33. Guerrini, G., G. Ciciani, F. Bruni, S. Selleri and C. Martini et al., 2011. Development of ligands at γ-aminobutyrric acid type A (GABAA) receptor subtype as new agents for pain relief. Bioorg. Med. Chem., 19: 7441-7452.
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  34. Fumagalli, M., S. Daniele, D. Lecca, P.R. Lee and C. Parravicini et al., 2011. Phenotypic changes, signaling pathway and functional correlates of GPR17-expressing neural precursor cells during oligodendrocyte differentiation. J. Biol. Chem., 286: 10593-10604.
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  35. Eberini, I., S. Daniele, C. Parravicini, C. Sensi, M.L. Trincavelli, C. Martini and M.P. Abbracchio, 2011. In silico identification of new ligands for GPR17: A promising therapeutic target for neurodegenerative diseases. J. Comput.-Aided Mol. Des., 25: 743-752.
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  36. Daniele, S., M.L. Trincavelli, P. Gabelloni, D. Lecca, P. Rosa, M.P. Abbracchio and C. Martini, 2011. Agonist-induced desensitization/resensitization of human G protein-coupled receptor 17: A functional cross-talk between purinergic and cysteinyl-leukotriene ligands. J. Pharmacol. Exp. Ther., 338: 559-567.
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  37. Damont, A., R. Boisgard, B. Kuhnast, F. Lemee and G. Raggiri et al., 2011. Synthesis of 6-[18F]fluoro-PBR28, a novel radiotracer for imaging the TSPO 18 kDa with PET. Bioorg. Med. Chem. Lett., 21: 4819-4822.
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  38. Costa, B., E. Da Pozzo, B. Chelli, N. Simola and M. Morelli et al., 2011. Anxiolytic properties of a 2-phenylindolglyoxylamide TSPO ligand: Stimulation of in vitro neurosteroid production affecting GABAA receptor activity. Psychoneuroendocrinology, 36: 463-472.
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  39. Cosimelli, B., S. Taliani, G. Greco, E. Novellino and A. Sala et al., 2011. Derivatives of benzimidazol-2-ylquinoline and benzimidazol-2-ylisoquinoline as selective A1 adenosine receptor antagonists with stimulant activity on human colon motility. ChemMedChem., 6: 1909-1918.
    CrossRef  |  Direct Link  |  

  40. Cosimelli, B., F. Simorini, S. Taliani, C. La Motta and F. Da Settimo et al., 2011. Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein. Eur. J. Med. Chem., 46: 4506-4520.
    CrossRef  |  Direct Link  |  

  41. Anzini, M., S. Valenti, C. Braile, A. Cappelli and S. Vomero et al., 2011. New insight into the central benzodiazepine receptor-ligand interactions: Design, synthesis, biological evaluation and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds. J. Med. Chem., 54: 5694-5711.
    CrossRef  |  Direct Link  |  

  42. Trincavelli, M.L., S. Daniele and C. Martini, 2010. Adenosine receptors: What we know and what we are learning. Curr. Top. Med. Chem., 10: 860-877.
    CrossRef  |  PubMed  |  

  43. Trincavelli, M.L., S. Cuboni, M.C. Dell'Osso, R. Maggio and K.N. Klotz et al., 2010. Receptor crosstalk: Haloperidol treatment enhances A2A adenosine receptor functioning in a transfected cell model. Purinergic Signall., 6: 373-381.
    CrossRef  |  PubMed  |  Direct Link  |  

  44. Tonazzini, I., E. Bystrenova, B. Chelli, P. Greco and P. Stoliar et al., 2010. Multiscale morphology of organic semiconductor thin films controls the adhesion and viability of human neural cells. Biophys. J., 98: 2804-2812.
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  45. Taliani, S., E. Da Pozzo, M. Bellandi, S. Bendinelli and I. Pugliesi et al., 2010. Novel irreversible fluorescent probes targeting the 18 kDa translocator protein: Synthesis and biological characterization. J. Med. Chem., 53: 4085-4093.
    CrossRef  |  PubMed  |  Direct Link  |  

  46. Taliani, S., C. La Motta, L. Mugnaini, F. Simorini and S. Salerno et al., 2010. Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: Inhibition of A3-mediated human glioblastoma cell proliferation. J. Med. Chem., 53: 3954-3963.
    CrossRef  |  PubMed  |  Direct Link  |  

  47. Reynolds, A., R. Hanani, D. Hibbs, A. Damont and E. Da Pozzo et al., 2010. Pyrazolo[1,5-a]pyrimidine acetamides: 4-Phenyl alkyl ether derivatives as potent ligands for the 18 kDa translocator protein (TSPO). Bioorg. Med. Chem. Lett., 20: 5799-5802.
    CrossRef  |  

  48. Guerrini, G., G. Ciciani, F. Bruni, S. Selleri and C. Guarino et al., 2010. New fluoro derivatives of the pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide system: Evaluation of fluorine binding properties in the benzodiazepine site on γ-aminobutyrric acid type A (GABAA) receptor. Design, synthesis, biological and molecular modeling investigation. J. Med. Chem., 53: 7532-7548.
    CrossRef  |  PubMed  |  Direct Link  |  

  49. Giorgioni, G., D. Ambrosini, C. Vesprini, A. Hudson and C. Nasuti et al., 2010. Novel imidazoline compounds as partial or full agonists of D2-like dopamine receptors inspired by I2-imidazoline binding sites ligand 2-BFI. Bioorg. Med. Chem., 18: 7085-7091.
    CrossRef  |  

  50. Gabelloni, P., E. Da Pozzo, S. Bendinelli, B. Costa and E. Nuti et al., 2010. Inhibition of metalloproteinases derived from tumours: New insights in the treatment of human glioblastoma. Neuroscience, 168: 514-522.
    CrossRef  |  PubMed  |  Direct Link  |  

  51. Dell'Osso L, E. Da Pozzo, C. Carmassi, M.L. Trincavelli, A. Ciapparelli and C. Martini, 2010. Lifetime manic-hypomanic symptoms in post-traumatic stress disorder: Relationship with the 18 kDa mitochondrial translocator protein density. Psychiatry Res., 177: 139-143.
    CrossRef  |  PubMed  |  Direct Link  |  

  52. Daniele, S., D. Lecca, M.L. Trincavelli, O. Ciampi, M.P. Abbracchio and C. Martini, 2010. Regulation of PC12 cell survival and differentiation by the new P2Y-like receptor GPR17. Cell. Signalling, 22: 697-706.
    CrossRef  |  

  53. Calleri, E., S. Ceruti, G. Cristalli, C. Martini and C. Temporini et al., 2010. Frontal affinity chromatography-mass spectrometry useful for characterization of new ligands for GPR17 receptor. J. Med. Chem., 53: 3489-3501.
    CrossRef  |  PubMed  |  Direct Link  |  

  54. Abelli, M., B. Chelli, B. Costa, L. Lari and A. Cardini et al., 2010. Reductions in platelet 18-kDa translocator protein density are associated with adult separation anxiety in patients with bipolar disorder. Neuropsychobiology, 62: 98-103.
    CrossRef  |  PubMed  |  Direct Link  |  

  55. Volpini, R., D. Dal Ben, C. Lambertucci, G. Marucci and R.C. Mishra et al., 2009. Adenosine A2A receptor antagonists: New 8-substituted 9-ethyladenines as tools for in vivo rat models of Parkinson's disease. ChemMedChem, 4: 1010-1019.
    CrossRef  |  PubMed  |  Direct Link  |  

  56. Tuccinardi, T., S. Taliani, M. Bellandi, F. Da Settimo, E. Da Pozzo, C. Martini and A. Martinelli, 2009. A virtual screening study of the 18 kDa translocator protein using pharmacophore models combined with 3D-QSAR studies. ChemMedChem, 4: 1686-1694.
    CrossRef  |  PubMed  |  Direct Link  |  

  57. Taliani, S., F. Da Settimo, E. Da Pozzo, B. Chelli and C. Martini, 2009. Translocator protein ligands as promising therapeutic tools for anxiety disorders. Curr. Med. Chem., 16: 3359-3380.
    CrossRef  |  PubMed  |  

  58. Taliani, S., B. Cosimelli, F. Da Settimo, A.M. Marini and C. La Motta et al., 2009. Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the γ-aminobutyric acid-A (GABAA) α2 benzodiazepine receptor. J. Med. Chem., 52: 3723-3734.
    CrossRef  |  PubMed  |  Direct Link  |  

  59. Pugliese, A.M., M.L. Trincavelli, D. Lecca, E. Coppi and M. Fumagalli et al., 2009. Functional characterization of two isoforms of the P2Y-like receptor GPR17: [35S]GTPγS binding and electrophysiological studies in 1321N1 cells. Am. J. Physiol.-Cell Physiol., 297: C1028-C1040.
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  60. Guerrini, G., G. Ciciani, G. Cambi, F. Bruni and S. Selleri et al., 2009. Synthesis, in vivo evaluation and molecular modeling studies of new pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide derivatives. Identification of a bifunctional hydrogen bond area related to the inverse agonism. J. Med. Chem., 52: 4668-4682.
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  61. Costa, B., S. Pini, P. Gabelloni, M. Abelli and L. Lari et al., 2009. Oxytocin receptor polymorphisms and adult attachment style in patients with depression. Psychoneuroendocrinology, 34: 1506-1514.
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  62. Costa, B., S. Pini, P. Gabelloni, E. Da Pozzo and M. Abelli et al., 2009. The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals. Endocrinology, 150: 5438-5445.
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  63. Costa, B., S. Pini, C. Martini, M. Abelli and P. Gabelloni et al., 2009. Mutation analysis of oxytocin gene in individuals with adult separation anxiety. Psychiatry Res., 168: 87-93.
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  64. Costa, B., S. Pini, C. Martini, M. Abelli and P. Gabelloni et al., 2009. Ala147Thr substitution in translocator protein is associated with adult separation anxiety in patients with depression. Psychiatric Genet., 19: 110-111.
    CrossRef  |  PubMed  |  

  65. Colotta, V., O. Lenzi, D. Catarzi, F. Varano and G. Filacchioni et al., 2009. Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a new scaffold to develop potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation and ligand-receptor modeling studies. J. Med. Chem., 52: 2407-2419.
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