Hi, I am Claudia Martini, My LiveDNA is 39.5920
 
   
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Prof. Claudia Martini
 
Highest Degree: Ph.D. in Biochemistry from University of Pisa, Italy
 
Institute: University of Pisa, Italy
 
Area of Interest: Biomedical Sciences
  •   Signal Transduction
  •   Receptors
  •   Neurodegenaration
  •   Cancer
 
URL: http://livedna.org/39.5920
 
My SELECTED Publications
1:   Abelli, M., B. Chelli, B. Costa, L. Lari and A. Cardini et al., 2010. Reductions in platelet 18-kDa translocator protein density are associated with adult separation anxiety in patients with bipolar disorder. Neuropsychobiology, 62: 98-103.
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2:   Anzini, M., S. Valenti, C. Braile, A. Cappelli and S. Vomero et al., 2011. New insight into the central benzodiazepine receptor-ligand interactions: Design, synthesis, biological evaluation and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds. J. Med. Chem., 54: 5694-5711.
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3:   Asteriti, S., S. Daniele, F. Porchia, M.T. Dell'anno and A. Fazzini et al., 2012. Modulation of PAR1 signalling by benzimidazole compounds. Br. J. Pharmacol., 167: 80-94.
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4:   Calleri, E., S. Ceruti, G. Cristalli, C. Martini and C. Temporini et al., 2010. Frontal affinity chromatography-mass spectrometry useful for characterization of new ligands for GPR17 receptor. J. Med. Chem., 53: 3489-3501.
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5:   Castellano, S., S. Taliani, C. Milite, I. Pugliesi and E. Da Pozzo et al., 2012. Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein. J. Med. Chem., 55: 4506-4510.
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6:   Colotta, V., O. Lenzi, D. Catarzi, F. Varano and G. Filacchioni et al., 2009. Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a new scaffold to develop potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation and ligand-receptor modeling studies. J. Med. Chem., 52: 2407-2419.
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7:   Cosimelli, B., F. Simorini, S. Taliani, C. La Motta and F. Da Settimo et al., 2011. Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein. Eur. J. Med. Chem., 46: 4506-4520.
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8:   Cosimelli, B., S. Taliani, G. Greco, E. Novellino and A. Sala et al., 2011. Derivatives of benzimidazol-2-ylquinoline and benzimidazol-2-ylisoquinoline as selective A1 adenosine receptor antagonists with stimulant activity on human colon motility. ChemMedChem., 6: 1909-1918.
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9:   Costa, B., A.F. Grillone, A. Salvetti, S. Rocchiccioli and P. Iacopetti et al., 2013. An antibody-free strategy for screening putative HDM2 inhibitors using crude bacterial lysates expressing GST-HDM2 recombinant protein. Drug Testing Anal., 5: 596-601.
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10:   Costa, B., E. Da Pozzo and C. Martini, 2012. Translocator protein as a promising target for novel anxiolytics. Curr. Top. Med. Chem., 12: 270-285.
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11:   Costa, B., E. Da Pozzo, B. Chelli, N. Simola and M. Morelli et al., 2011. Anxiolytic properties of a 2-phenylindolglyoxylamide TSPO ligand: Stimulation of in vitro neurosteroid production affecting GABAA receptor activity. Psychoneuroendocrinology, 36: 463-472.
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12:   Costa, B., S. Bendinelli, P. Gabelloni, E. Da Pozzo and S. Daniele et al., 2013. Human glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor. PLoS ONE, Vol. 8. 10.1371/journal.pone.0072281.
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13:   Costa, B., S. Pini, C. Martini, M. Abelli and P. Gabelloni et al., 2009. Ala147Thr substitution in translocator protein is associated with adult separation anxiety in patients with depression. Psychiatric Genet., 19: 110-111.
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14:   Costa, B., S. Pini, C. Martini, M. Abelli and P. Gabelloni et al., 2009. Mutation analysis of oxytocin gene in individuals with adult separation anxiety. Psychiatry Res., 168: 87-93.
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15:   Costa, B., S. Pini, M. Abelli, P. Gabelloni and E. Da Pozzo et al., 2012. Role of translocator protein (18 kDa) in adult separation anxiety and attachment style in patients with depression. Curr. Mol. Med., 12: 483-487.
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16:   Costa, B., S. Pini, P. Gabelloni, E. Da Pozzo and M. Abelli et al., 2009. The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals. Endocrinology, 150: 5438-5445.
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17:   Costa, B., S. Pini, P. Gabelloni, M. Abelli and L. Lari et al., 2009. Oxytocin receptor polymorphisms and adult attachment style in patients with depression. Psychoneuroendocrinology, 34: 1506-1514.
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18:   Da Pozzo, E., B. Costa and C. Martini, 2012. Translocator Protein (TSPO) and neurosteroids: Implications in psychiatric disorders. Curr. Mol. Med., 12: 426-442.
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19:   Da Pozzo, E., M.C. Barsotti, S. Bendinelli, A. Martelli and V. Calderone et al., 2012. Differential effects of fondaparinux and bemiparin on angiogenic and vasculogenesis-like processes. Thrombosis Res., 130: e113-e122.
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20:   Damont, A., R. Boisgard, B. Kuhnast, F. Lemee and G. Raggiri et al., 2011. Synthesis of 6-[18F]fluoro-PBR28, a novel radiotracer for imaging the TSPO 18 kDa with PET. Bioorg. Med. Chem. Lett., 21: 4819-4822.
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21:   Daniele, S., D. Lecca, M.L. Trincavelli, O. Ciampi, M.P. Abbracchio and C. Martini, 2010. Regulation of PC12 cell survival and differentiation by the new P2Y-like receptor GPR17. Cell. Signalling, 22: 697-706.
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22:   Daniele, S., E. Da Pozzo, M. Abelli, A. Panighini and S. Pini et al., 2012. Platelet uptake of GABA and glutamate in patients with bipolar disorder. Bipolar Disorders, 14: 301-308.
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23:   Daniele, S., M.L. Trincavelli, P. Gabelloni, D. Lecca, P. Rosa, M.P. Abbracchio and C. Martini, 2011. Agonist-induced desensitization/resensitization of human G protein-coupled receptor 17: A functional cross-talk between purinergic and cysteinyl-leukotriene ligands. J. Pharmacol. Exp. Ther., 338: 559-567.
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24:   Dell'Osso L, E. Da Pozzo, C. Carmassi, M.L. Trincavelli, A. Ciapparelli and C. Martini, 2010. Lifetime manic-hypomanic symptoms in post-traumatic stress disorder: Relationship with the 18 kDa mitochondrial translocator protein density. Psychiatry Res., 177: 139-143.
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25:   Dell'Osso, L., D. Marazziti, E. Da Pozzo, C. Conversano and S. Baroni et al., 2012. Gender effect on the relationship between stress hormones and panic-agoraphobic spectrum dimensions in healthy subjects. CNS Spectrums, 17: 214-220.
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26:   Eberini, I., S. Daniele, C. Parravicini, C. Sensi, M.L. Trincavelli, C. Martini and M.P. Abbracchio, 2011. In silico identification of new ligands for GPR17: A promising therapeutic target for neurodegenerative diseases. J. Comput.-Aided Mol. Des., 25: 743-752.
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27:   Fogli, S., F. Stefanelli, A. Martelli, S. Daniele and L. Testai et al., 2013. Protective effect of high-dose montelukast on salbutamol-induced homologous desensitisation in airway smooth muscle. Pulmonary Pharmacol. Ther., 26: 693-699.
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28:   Fumagalli, M., S. Daniele, D. Lecca, P.R. Lee and C. Parravicini et al., 2011. Phenotypic changes, signaling pathway and functional correlates of GPR17-expressing neural precursor cells during oligodendrocyte differentiation. J. Biol. Chem., 286: 10593-10604.
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29:   Gabelloni, P., E. Da Pozzo, S. Bendinelli, B. Costa and E. Nuti et al., 2010. Inhibition of metalloproteinases derived from tumours: New insights in the treatment of human glioblastoma. Neuroscience, 168: 514-522.
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30:   Giorgioni, G., D. Ambrosini, C. Vesprini, A. Hudson and C. Nasuti et al., 2010. Novel imidazoline compounds as partial or full agonists of D2-like dopamine receptors inspired by I2-imidazoline binding sites ligand 2-BFI. Bioorg. Med. Chem., 18: 7085-7091.
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31:   Giorgioni, G., D. Ambrosini, G.F. Palmieri, B. Costa, A. Di Stefano and C. Martini, 2012. Synthesis of novel 4-aryl-1,2,3,4-tetrahydroisoquinolines as probes for dopamine receptor ligands. Med. Chem., 8: 699-704.
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32:   Graziano, A., M.P. Giovannoni, A. Cilibrizzi, L. Crocetti and V.D. Piaz et al., 2012. New pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones fluoroderivatives as human A1 adenosine receptor ligands. Acta Chimica Slovenica, 59: 648-655.
PubMed  |  
33:   Guerrini, G., G. Ciciani, F. Bruni, S. Selleri and C. Guarino et al., 2010. New fluoro derivatives of the pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide system: Evaluation of fluorine binding properties in the benzodiazepine site on γ-aminobutyrric acid type A (GABAA) receptor. Design, synthesis, biological and molecular modeling investigation. J. Med. Chem., 53: 7532-7548.
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34:   Guerrini, G., G. Ciciani, F. Bruni, S. Selleri and C. Martini et al., 2011. Development of ligands at γ-aminobutyrric acid type A (GABAA) receptor subtype as new agents for pain relief. Bioorg. Med. Chem., 19: 7441-7452.
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35:   Guerrini, G., G. Ciciani, F. Bruni, S. Selleri and F. Melani et al., 2011. New 3-, 8-disubstituted pyrazolo[5,1-c][1,2,4]benzotriazines useful for studying the interaction with the HBp-3 area (hydrogen bond point area) in the benzodiazepine site on the γ-aminobutyric acid type A (GABAA) receptor. Bioorg. Med. Chem., 19: 3074-3085.
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36:   Guerrini, G., G. Ciciani, G. Cambi, F. Bruni and S. Selleri et al., 2009. Synthesis, in vivo evaluation and molecular modeling studies of new pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide derivatives. Identification of a bifunctional hydrogen bond area related to the inverse agonism. J. Med. Chem., 52: 4668-4682.
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37:   La Regina, G., R. Bai, W.M. Rensen, E. Di Cesare and A. Coluccia et al., 2013. Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors. J. Med. Chem., 56: 123-149.
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38:   Luykx, J.J., M.P.M. Boks, E.J. Breetvelt, M.F. Aukes and E. Strengman et al., 2013. BDNF Val66Met homozygosity does not influence plasma BDNF levels in healthy human subjects. Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 43: 185-187.
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39:   Maggio, B., D. Raffa, M.V. Raimondi, F. Plescia and M.L. Trincavelli et al., 2012. Synthesis, benzodiazepine receptor binding and molecular modelling of isochromeno[4,3-c]pyrazol-5(1H)-one derivatives. Eur. J. Med. Chem., 54: 709-720.
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40:   Martini, C., E. Da Pozzo, C. Carmassi, S. Cuboni and M.L. Trincavelli et al., 2013. Cyclic adenosine monophosphate responsive element binding protein in post-traumatic stress disorder. World J. Biol. Psychiatry, 14: 396-402.
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41:   Martini, C., S. Daniele, M. Picchetti, A. Panighini and M. Carlini et al., 2011. A2A adenosine receptor binding parameters in platelets from patients affected by pathological gambling. Neuropsychobiology, 63: 154-159.
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42:   Nuti, E., F. Casalini, S. Santamaria, P. Gabelloni and S. Bendinelli et al., 2011. Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors. Eur. J. Med. Chem., 46: 2617-2629.
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43:   Pike, V.W., S. Taliani, T.G. Lohith, D.R. Owen and I. Pugliesi et al., 2011. Evaluation of novel N1-methyl-2-phenylindol-3-ylglyoxylamides as a new chemotype of 18 kDa translocator protein-selective ligand suitable for the development of positron emission tomography radioligands. J. Med. Chem., 54: 366-373.
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44:   Poli, D., D. Catarzi, V. Colotta, F. Varano and G. Filacchioni et al., 2011. The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists. J. Med. Chem., 54: 2102-2113.
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45:   Pugliese, A.M., M.L. Trincavelli, D. Lecca, E. Coppi and M. Fumagalli et al., 2009. Functional characterization of two isoforms of the P2Y-like receptor GPR17: [35S]GTPγS binding and electrophysiological studies in 1321N1 cells. Am. J. Physiol.-Cell Physiol., 297: C1028-C1040.
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46:   Raccosta, L., R. Fontana, D. Maggioni, C. Lanterna and E.J. Villablanca et al., 2013. The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils. J. Exp. Med., 210: 1711-1728.
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47:   Reynolds, A., R. Hanani, D. Hibbs, A. Damont and E. Da Pozzo et al., 2010. Pyrazolo[1,5-a]pyrimidine acetamides: 4-Phenyl alkyl ether derivatives as potent ligands for the 18 kDa translocator protein (TSPO). Bioorg. Med. Chem. Lett., 20: 5799-5802.
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48:   Scarf, A.M., C. Luus, E. Da Pozzo, S. Selleri and C. Guarino et al., 2012. Evidence for complex binding profiles and species differences at the Translocator Protein (TSPO) (18 kDa). Curr. Mol. Med., 12: 488-493.
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49:   Scatena, A., F. Fornai, M.L. Trincavelli, S. Taliani and S. Daniele et al., 2011. 3-(Fur-2-yl)-10-(2-phenylethyl)-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one, a novel adenosine receptor antagonist with A2A-mediated neuroprotective effects. ACS Chem. Neurosci., 2: 526-535.
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50:   Simoni, E., S. Daniele, G. Bottegoni, D. Pizzirani and M.L. Trincavelli et al., 2012. Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease. J. Med. Chem., 55: 9708-9721.
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51:   Taliani, S., B. Cosimelli, F. Da Settimo, A.M. Marini and C. La Motta et al., 2009. Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the γ-aminobutyric acid-A (GABAA) α2 benzodiazepine receptor. J. Med. Chem., 52: 3723-3734.
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52:   Taliani, S., C. La Motta, L. Mugnaini, F. Simorini and S. Salerno et al., 2010. Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: Inhibition of A3-mediated human glioblastoma cell proliferation. J. Med. Chem., 53: 3954-3963.
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53:   Taliani, S., E. Da Pozzo, M. Bellandi, S. Bendinelli and I. Pugliesi et al., 2010. Novel irreversible fluorescent probes targeting the 18 kDa translocator protein: Synthesis and biological characterization. J. Med. Chem., 53: 4085-4093.
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54:   Taliani, S., F. Da Settimo, E. Da Pozzo, B. Chelli and C. Martini, 2009. Translocator protein ligands as promising therapeutic tools for anxiety disorders. Curr. Med. Chem., 16: 3359-3380.
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55:   Taliani, S., I. Pugliesi, E. Barresi, F. Simorini and S. Salerno et al., 2012. 3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: A novel template for the design of highly selective A2B adenosine receptor antagonists. J. Med. Chem., 55: 1490-1499.
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56:   Taliani, S., M.L. Trincavelli, B. Cosimelli, S. Laneri and E. Severi et al., 2013. Modulation of A2B adenosine receptor by 1-benzyl-3-ketoindole derivatives. Eur. J. Med. Chem., 69: 331-337.
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57:   Tonazzini, I., E. Bystrenova, B. Chelli, P. Greco and P. Stoliar et al., 2010. Multiscale morphology of organic semiconductor thin films controls the adhesion and viability of human neural cells. Biophys. J., 98: 2804-2812.
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58:   Trincavelli, M.L., E. Da Pozzo, O. Ciampi, S. Cuboni, S. Daniele, M.P. Abbracchio and C. Martini, 2013. Regulation of erythropoietin receptor activity in endothelial cells by different Erythropoietin (EPO) derivatives: An in vitro study. Int. J. Mol. Sci., 14: 2258-2281.
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59:   Trincavelli, M.L., E. Da Pozzo, S. Daniele and C. Martini, 2012. The GABAA-BZR complex as target for the development of anxiolytic drugs. Curr. Top. Med. Chem., 12: 254-269.
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60:   Trincavelli, M.L., S. Cuboni, M.C. Dell'Osso, R. Maggio and K.N. Klotz et al., 2010. Receptor crosstalk: Haloperidol treatment enhances A2A adenosine receptor functioning in a transfected cell model. Purinergic Signall., 6: 373-381.
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61:   Trincavelli, M.L., S. Daniele and C. Martini, 2010. Adenosine receptors: What we know and what we are learning. Curr. Top. Med. Chem., 10: 860-877.
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62:   Trincavelli, M.L., S. Daniele, E. Orlandini, G. Navarro and V. Casado et al., 2012. A new D2 dopamine receptor agonist allosterically modulates A2A adenosine receptor signalling by interacting with the A2A/D2 receptor heteromer. Cell. Signall., 24: 951-960.
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63:   Tuccinardi, T., A.T. Zizzari, C. Brullo, S. Daniele and F. Musumeci et al., 2011. Substituted pyrazolo[3,4-b]pyridines as human A1 adenosine antagonists: Developments in understanding the receptor stereoselectivity. Org. Biomol. Chem., 9: 4448-4455.
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64:   Tuccinardi, T., S. Taliani, M. Bellandi, F. Da Settimo, E. Da Pozzo, C. Martini and A. Martinelli, 2009. A virtual screening study of the 18 kDa translocator protein using pharmacophore models combined with 3D-QSAR studies. ChemMedChem, 4: 1686-1694.
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65:   Volpini, R., D. Dal Ben, C. Lambertucci, G. Marucci and R.C. Mishra et al., 2009. Adenosine A2A receptor antagonists: New 8-substituted 9-ethyladenines as tools for in vivo rat models of Parkinson's disease. ChemMedChem, 4: 1010-1019.
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