Dr. Alessandro  Poggi

Dr. Alessandro Poggi

Head of Academic Department/Faculty
National Institute for Cancer Research, Italy


Highest Degree
PostDoc. in Allergology and Clinical Immunology from University of Genoa, Italy

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Area of Interest:

Biomedical Sciences
100%
Immunology
62%
Experimental Medicine
90%
Cytometry
75%
Cancer
55%

Education

2004

PostDoc.

University of Genoa, Italy

Allergology and Clinical Immunology

Selected Publications

  1. Zocchi, M.R., D. Costa, R. Venè, F. Tosetti and N. Ferrari,et al 2017. Zoledronate can induce colorectal cancer microenvironment expressing BTN3A1 to stimulate effector γδ T cells with antitumor activity. Oncoimmunology, 10.1080/2162402X.2016.1278099.
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  2. Roncella, S., S. Laurent, V. Fontana, P. Ferro and M.C. Franceschini,et al 2016. CTLA-4 in mesothelioma patients: Tissue expression, body fluid levels and possible relevance as a prognostic factor. Cancer Immunol. Immunother., 65: 909-917.
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  3. Poggi, A. and M. Giuliani, 2016. Mesenchymal stromal cells can regulate the immune response in the tumor microenvironment. Vaccines (Basel). 10.3390/vaccines4040041.
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  4. Pereira, R.C., D. Martinelli, R. Cancedda, C. Gentili and A. Poggi, 2016. Human articular chondrocytes regulate immune response by affecting directly t cell proliferation and indirectly inhibiting monocyte differentiation to professional antigen-presenting cells. Front. Immunol., 10.3389/fimmu.2016.00415.
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  5. Penna, I., A. Gigoni, D. Costa, S. Vella and D. Russo,et al 2016. The inhibition of 45A ncRNA expression reduces tumor formation, affecting tumor nodules compactness and metastatic potential in neuroblastoma cells. Oncotarget, 8: 8189-8205.
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  6. Papait, A., R. Cancedda, M. Mastrogiacomo and A. Poggi, 2016. Allogeneic platelet-rich plasma affects monocyte differentiation to dendritic cells causing an anti-inflammatory microenvironment, putatively fostering wound healing. J. Tissue. Eng. Regen. Med., 10.1002/term.2361.
    CrossRef  |  Direct Link  |  

  7. Lasiglie, D., S. Boero, I. Bauer, S. Morando and P. Damonte,et al 2016. Sirt6 regulates dendritic cell differentiation, maturation, and function. Aging (Albany NY). 8: 34-49.
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  8. Camodeca, C., E. Nuti, L. Tepshi, S. Boero and T. Tuccinardi,et al 2016. Discovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell models. Eur. J. Med. Chem., 111: 193-201.
    CrossRef  |  Direct Link  |  

  9. Zocchi, M.R., C. Camodeca, E. Nuti, A. Rossello and R. Vene,et al 2015. ADAM10 new selective inhibitors reduce NKG2D ligand release sensitizing Hodgkin lymphoma cells to NKG2D-mediated killing. Oncoimmunology, 10.1080/2162402X.2015.1123367.
    CrossRef  |  Direct Link  |  

  10. Vene, R., F. Tosetti, S. Minghelli, A. Poggi, N. Ferrari and R. Benelli, 2015. Celecoxib increases EGF signaling in colon tumor associated fibroblasts, modulating EGFR expression and degradation. Oncotarget, 6: 12310-12325.
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  11. Poggi, A. and M.R. Zocchi, 2015. Mesenchymal stromal cells as regulators of anti-tumour immune response.. Indian J. Med. Res., 141: 139-142.
    Direct Link  |  

  12. Muraglia, A., M.R. Todeschi, A. Papait, A. Poggi and R. Spano,et al 2015. Combined platelet and plasma derivatives enhance proliferation of stem/progenitor cells maintaining their differentiation potential. Cytotherapy, 17: 1793-1806.
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  13. Montecucco, F., S. Lenglet, F. Carbone, S. Boero and G. Pelli,et al 2015. Treatment with KLEPTOSE® CRYSMEB reduces mouse atherogenesis by impacting on lipid profile and Th1 lymphocyte response. Vascul. Pharmacol., 72: 197-208.
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  14. Boero, S., A. Morabito, B. Banelli, B. Cardinali and B. Dozin,et al 2015. Analysis of in vitro ADCC and clinical response to trastuzumab: Possible relevance of FcγRIIIA/FcγRIIA gene polymorphisms and HER-2 expression levels on breast cancer cell lines. J. Transl. Med., 13: 324-393.
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  15. Vecchio, D., A. Daga, E. Carra, D. Marubbi and Baio.G et al., 2014. Predictability, efficacy and safety of radiosensitization of glioblastoma-initiating cells by the ATM inhibitor KU-60019. Int. J. Cancer, 135: 479-491.
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  16. Poggi, A., A. Musso, I. Dapino and M.R. Zocchi, 2014. Mechanisms of tumor escape from immune system: role of mesenchymal stromal cells. Immunol Lett., 159: 55-72.
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  17. Poggi, A. and MR. Zocchi, 2014. Stress immunity in lymphomas: mesenchymal cells as a target of therapy. Front Biosci. (Landmark Ed.), 19: 281-290.
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  18. Musso, A., S. Catellani, P. Canevali, S. Tavella and R. Vene et al., 2014. Aminobisphosphonates prevent the inhibitory effects exerted by lymph node stromal cells on anti-tumor vδ 2 t lymphocytes in non-hodgkin lymphomas. Hematol. J., 99: 131-139.
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  19. Scabini, S., F. Montecucco, A. Nencioni, G. Zoppoli and M. Sartini et al., 2013. The effect of preoperative chemoradiotherapy on lymph nodes harvested in tme for rectal cancer. World J. Surg. Oncol., 11: 292-292.
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  20. Penna, I., I. Vassallo, M. Nizzari, D. Russo and D. Costa et al., 2013. A novel snRNA-like transcript affects amyloidogenesis and cell cycle progression through perturbation of Fe65L1 (APBB2) alternative splicing. Biochim. Biophys. Acta, 1833: 1511-1526.
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  21. Amaro, A., V. Mirisola, G. Angelini, A. Musso and F. Tosetti et al., 2013. Evidence of epidermal growth factor receptor expression in uveal melanoma: inhibition of epidermal growth factor-mediated signalling by gefitinib and cetuximab triggered antibody-dependent cellular cytotoxicity. Eur. J. Cancer, 49: 3353-3365.
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  22. Poggi, A., P. Canevali, M. Contatore and G. Ciprandi, 2012. Higher frequencies of CD161+ circulating T lymphocytes in allergic rhinitis patients compared to healthy donors. Int. Arch. Allergy Immunol., 158: 151-156.
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  23. Poggi, A. and M.R. Zocchi, 2012. Imatinib mesylate can help to direct natural immunity toward an anti-leukemic reactivity by acting on the bone marrow microenvironment. Oncoimmunology, 1: 214-216.
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  24. Montecucco, F., I. Bauer, V. Braunersreuther, S. Bruzzone and A. Poggi et al., 2012. Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction. Antioxid Redox Signal, 18: 630-641.
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  25. Magnone, M., I. Bauer, A. Poggi, E. Mannino and L. Sturla et al., 2012. NAD+ levels control Ca2+ store replenishment and mitogen-induced increase of cytosolic Ca2+ by cyclic ADP-ribose-dependent TRPM2 channel gating in human T lymphocytes. J. Biol. Chem., 287: 21067-21081.
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  26. Boggio, E., M. Melensi, S. Bocca, A. Chiocchetti and C. Comi et al., 2012. The -346T Polymorphism of the SH2D1A gene is a risk factor for development of autoimmunity/lymphoproliferation in males with defective Fas function. Hum. Immunol., 73: 585-592.
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  27. Bauer, I., A. Grozio, D. Lasiglie, G. Basile and L. Sturla et al., 2012. The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses. J. Biol. Chem., 287: 40924-40937.
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  28. Zocchi, M.R. and A. Poggi, 2011. Targeting the microenvironment in hematological malignancies: how to condition both stromal and effector cells to overcome cancer spreading. Curr. Med. Chem., 18: 5172-5173.
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  29. Ropolo, M., E. Cappelli, M. Foresta, A. Poggi, L. Proietti-De-Santis and G. Frosina, 2011. Defective resolution of pH2AX foci and enhanced DNA breakage in ionizing radiation-treated Cockayne syndrome B cells. IUBMB Life, 63: 272-276.
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  30. Poggi, A. and M.R. Zocchi, 2011. Modulating mesenchymal stromal cell function with cholesterol synthesis inhibitors. Curr. Med. Chem., 18: 5196-5205.
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  31. Mirabella, T., A. Poggi, M. Scaranari, M. Mogni and M. Lituania et al., 2011. Recruitment of host's progenitor cells to sites of human amniotic fluid stem cells implantation. Biomaterials, 32: 4218-4227.
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  32. Ghio M., P. Contini, S. Negrini, C. Mazzei, M.R. Zocchi and A. Poggi, 2011. Down regulation of human Natural Killer cell-mediated cytolysis induced by blood transfusion: Role of transforming growth factor β1 soluble Fasligand and soluble class I human leukocyte antigen. Transfusion, 51: 1567-1673.
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  33. Fenoglio, D., M.R. Zocchi, A. Parodi, P. Durando, G. Gabutitp, R. Gasparini and A. Poggi, 2011. MF-59 adjuvant influence on the functions of gammadelta T cells in HIV-1+ adults immunized with influenza seasonal vaccine. J. Prev. Med. Hyg., 52: 137-141.
    PubMed  |  Direct Link  |  

  34. Poggi, A., M. Zancolli, S. Catellani, S. Boero, A. Musso and M.R. Zocchi, 2010. Differential survival of γδT cells, αβT cells and NK cells upon engagement of NKG2D by NKG2DL-expressing leukemic cells. Int. J. Cancer, 129: 387-396.
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  35. Poggi, A., C. Prevosto, S. Catellani, I. Rocco, A. Garuti and M.R. Zocchi, 2010. Engagement of CD31 delivers an activating signal that contributes to the survival of chronic lymphocytic leukaemia cells. Br. J. Haematol., 151: 252-264.
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  36. Poggi A., A. Musso, S. Boero, P. Canevali and M.R. Zocchi, 2010. Statins as either immunomodulators or anticancer drugs: Functional activities on tumor stromal cells and natural killer cells. CMCAIAA, 9: 82-92.
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  37. Musso, A., M.R. Zocchi and A. Poggi, 2010. Relevance of the mevalonate biosynthetic pathway in the regulation of bone marrow mesenchymal stromal cell-mediated effects on T-cell proliferation and B-cell survival. Haematologica, 96: 16-23.
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  38. Foresta, M., M. Ropolo, P. Degan, I. Pettinati and I.W. Kow et al., 2010. Defective repair of 5-Hydroxy-2'-deoxycytidine in cockayne syndrome cells and its complementation by Escherichia coli formamidopyrimidine DNA glycosylase and endonuclease III. Free Radic Biol. Med., 48: 681-690.
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  39. Ropolo, M., A. Daga, F. Griffero, M. Foresta and G.L. Casartelli et al., 2009. A comparative analysis of DNA repair in stem and non-stem glioma cell cultures. Mol. Cancer Res., 7: 383-392.
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  40. Poggi, A., S. Castellani, A. Musso and M.R. Zocchi, 2009. Gammadelta T lymphocytes producing IFNγ and IL-17 in response to Candida albicans or mycobacterial antigens: Possible implications for acute and chronic inflammation. Curr. Med. Chem., 16: 4743-4749.
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  41. Fenoglio, D., A. Poggi, S. Catellani, F. Battaglia and Al. Ferrera et al., 2009. Vδ1 T lymphocytes producing IFN-γ and IL-17 are expanded in HIV-1-infected patients and respond to Candida albicans. Blood, 113: 6611-6618.
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  42. Viale, M., M. Petrillo, M. Taccagno, P. Castagnola and C. Aiello et al., 2008. Sensitivity of different resistant tumour cell lines to the two novel compounds (2Z,4E)-2-methylsulfanyl-5-(1-naphthyl)-4-nitro-2,4-pentadienoate and (1E,3E)-1,4-bis(2-naphthyl)-2,3-dinitro-1,3-butadiene. Eur. J. Pharmacol., 588: 47-51.
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  43. Ponassi, R., B. Biasotti, V. Tomati, S. Bruno and A. Poggi et al., 2008. A novel Bim-BH3-derived Bcl-XL inhibitor: Biochemical characterization, in vitro, in vivo and ex-vivo anti-leukemic activity. Cell. Cycle., 7: 3211-3224.
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  44. Poggi, A., S. Catellani, A. Bruzzone, F. Caligaris-Cappio, M. Gobbi and M.R. Zocchi, 2008. Lack of the Leukocyte-associated Ig-like receptor-1 expression in high-risk chronic lymphocytic leukaemia results in the absence of a negative signal regulating kinase activation and cell division. Leukemia, 22: 980-988.
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  45. Poggi, A. and M.R. Zocchi, 2008. Role of bone marrow stromal cells in the generation of human CD8+ regulatory T cells. Human Immunol., 69: 755-759.
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  46. Patterson, S., A. Chaidos, D.C.A. Neville, A. Poggi and T. Butters et al., 2008. Human invariant NKT cells display alloreactivity instructed by invariant TCR-CD1d interaction and killer immunoglobulin receptors. J. Immunol., 181: 3268-3276.
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  47. Lombardi, M.L., G. Terrazzano, E. Casentini, L. Gargiulo and A. Risitano et al., 2008. Paroxysmal nocturnal hemoglobinuria: Significant association with specific HLA-A, -B, -C and -DR alleles in an Italian population. Human Immunol., 69: 202-206.
    CrossRef  |  PubMed  |  Direct Link  |  

  48. Vene, R., G. Arena, A. Poggi, C. D'Arrigo and M. Mormino et al., 2007. Novel cell death pathways induced by N-(4-hydroxyphenyl)retinamide: Therapeutic implications. Mol. Cancer Ther., 6: 286-298.
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  49. Ropolo, M., P. Degan, M. Foresta, M. D'errico and D. Lasiglie et al., 2007. Complementation of the oxidatively damaged DNA repair defect in Cockayne syndrome A and B cells by Escherichia coli formamidopyrimidine DNA glycosylase. Free Radic. Biol. Med., 42: 1807-1817.
    CrossRef  |  PubMed  |  Direct Link  |  

  50. Prevosto, C., M. Zancolli, P. Canevali, M.R. Zocchi and A. Poggi, 2007. Generation of CD4+ or CD8+ regulatory T cells upon mesenchymal stem cell-lymphocyte interaction. Haematologica, 92: 881-888.
    CrossRef  |  PubMed  |  Direct Link  |  

  51. Poggi, A., M. Zancolli, S. Castellani, G. Borsellino, L. Battistini and M.R. Zocchi, 2007. Migratory pathways of γδ T cells and response to CXCR3 and CXCR4 ligands: Adhesion molecules involved and implications for multiple sclerosis pathogenesis. Ann. NY Acad. Sci., 1107: 68-78.
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  52. Poggi, A., C. Prevosto, M. Zancolli, P. Canevali, A. Musso and M.R. Zocchi, 2007. NKG2D and natural cytotoxicity receptors are involved in natural killer cell interaction with self-antigen presenting cells and stromal cells. Ann. NY Acad. Sci., 1109: 47-57.
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  53. Poggi, A., C. Castellani, D. Fenoglio, G. Borsellino, L. Battistini and M.R. Zocchi, 2007. Adhesion molecules and kinases involved in γ δ T cells migratory pathways: Implications for viral and autoimmune diseases. Curr. Med. Chem., 14: 3166-3170.
    CrossRef  |  PubMed  |  Direct Link  |  

  54. Poggi, A. and M.R. Zocchi, 2007. Human natural killer lymphocytes through the engagement of natural cytotoxicity receptors and NKG2D can trigger self-aggression. Autoimmun. Rev., 6: 295-299.
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  55. Contini, P., M.R. Zocchi, I. Pierri, A. Albarello and A. Poggi, 2007. In vivo apoptosis of CD8+ lymphocytes in acute myeloid leukemia patients: involvement of soluble HLA-I and Fas ligand. Leukemia, 21: 253-260.
    CrossRef  |  PubMed  |  Direct Link  |  

  56. Catellani, S., A. Poggi, A. Bruzzone, P. Dadati, J.L. Ravetti, M. Gobbi and M.R. Zocchi, 2007. Expansion of Vδ1 T lymphocytes producing IL-4 in low-grade non-Hodgkin lymphomas expressing UL-16-binding proteins. Blood, 109: 2078-2085.
    CrossRef  |  PubMed  |  Direct Link  |  

  57. Scielzo, C., A. Camporeale, M. Geuna, M. Alessio, A. Poggi, M.R. Zocchi and M. Chilosi, 2006. ZAP-70 is expressed by normal and malignant human B-cell subsets of different maturational stage. Leukemia, 20: 689-695.
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  58. Poggi, A. and M.R. Zocchi, 2006. HIV-1 tat triggers TGF-β production and NK cell apoptosis that is prevented by pertussis toxin B. Clin. Dev. Immunol., 13: 369-372.
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  59. Poggi, A. and M.R. Zocchi, 2006. Antigen presenting cells and stromal cells trigger human natural killer lymphocytes to autoreactivity: Evidence for the involvement of Natural Cytotoxicity Receptors (NCR) and NKG2D. Clin. Dev. Immunol., 13: 325-326.
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  60. Zocchi, M.R., P. Contini, M. Alfano and A. Poggi, 2005. Pertussis toxin (PTX) B subunit and the nontoxic PTX mutant PT9K/129G inhibit tat-induced TGF-β production by NK cells and TGF-β-mediated NK cell apoptosis 1. J. Immunol., 174: 6054-6061.
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  61. Zocchi, M.R. and A. Poggi, 2005. Triggering of apoptosis and pro-inflammatory cytokines in NK cells: Regulation by cyclosporin A. Curr. Med. Chem., 4: 115-120.
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  62. Zocchi, M.R. and A. Poggi, 2005. Editorial [Hot topic: Innate immunity and cytokines: How to regulate host response against pathogens avoiding autoreactivity (Guest Editors: M.R. Zocchi and A. Poggi)]. Curr. Med. Chem., 4: 113-114.
    Direct Link  |  

  63. Semino, C., G. Angelini, A. Poggi and A. Rubartelli, 2005. NK/iDC interaction results in IL-18 secretion by DCs at the synaptic cleft followed by NK cell activation and release of the Dc maturation factor HMGB1. Blood, 106: 609-616.
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  64. Poggi, A., S. Negrini, M.R. Zocchi, A.M. Massaro and L. Garbarino, 2005. Patients with paroxysmal nocturnal Hemoglobinuria have a high frequency of peripheral-blood T cells expressing activating isoforms of inhibiting superfamily receptors. Blood, 106: 2399-2408.
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  65. Poggi, A., P. Contini, S. Castellani, M. Setti, G. Murdaca and M.R. Zocchi, 2005. Regulation of γδ T cell survival by soluble HLA-I: Involvement of CD8 and activating killer Ig-like receptors. Eur. J. Immunol., 35: 2670-2678.
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  66. Poggi, A., C. Prevosto, A.M. Massaro, S. Negrini and S. Urbani et al., 2005. Interaction between human NK cells and bone marrow stromal cells induces NK cell triggering: Role of NKp30 and NKG2D receptors. J. Immunol., 175: 6352-6360.
    CrossRef  |  PubMed  |  Direct Link  |  

  67. Poggi, A., A.M. Massaro, S. Negrini, P. Contini and M.R. Zocchi, 2005. Tumor-induced apoptosis of human IL-2-activated NK cells: Role of natural cytotoxicity receptors. J. Immunol., 174: 2656-2660.
    CrossRef  |  PubMed  |  Direct Link  |  

  68. Poggi, A. and M.R. Zocchi, 2005. Cyclosporin A regulates human NK cell apoptosis induced by soluble HLA-I or by target cells. Autoimmun. Rev., 4: 532-536.
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  69. Contini, P., M. Ghio, A. Merlo, A. Poggi, F. Indiveri and F. Puppo, 2005. Apoptosis of antigen-specific T lymphocytes upon the engagement of CD8 by soluble HLA class I molecules is Fas ligand/Fas mediated: Evidence for the involvement of p56lck, calcium calmodulin kinase II and Calcium-Independent Protein Kinase C signaling pathways and for NF-κB and NF-AT nuclear translocation. J. Immunol., 175: 7244-7254.
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  70. Chan, W.L., N. Pejnovic, H. Hamilton, T.V. Liew, D. Popadic, A. Poggi and S.M. Khan, 2005. Atherosclerotic abdominal aortic aneurysm and the interaction between autologous human plaque-derived vascular smooth muscle cells, type 1 NKT and helper T cells. Circ. Res., 96: 675-683.
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  71. Zocchi, M.R. and A. Poggi, 2004. Role of gammadelta T lymphocytes in tumor defense. Frontiers Biosci., 9: 2588-2604.
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  72. Zocchi, M.R. and A. Poggi, 2004. PECAM-1, apoptosis and CD34+ precursors. Leukemia Lymphoma, 45: 2205-2213.
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  73. Ropoli, M., A. Geroldi, O. Rossi, P. Degan, S. Zupo, A. Poggi and G. Frosina, 2004. Expression of the Drosophila melanogaster S3 ribosomal/repair protein in T24 human bladder cells. Anticancer Res., 24: 3811-3818.
    PubMed  |  Direct Link  |  

  74. Poggi, A., C. Venturino, S. Castellani, M. Clavio and M. Miglino et al., 2004. Vδ1 T lymphocytes from B-CLL patients recognize ULBP3 expressed on leukemic B cells and up-regulated by trans-retinoic acid. Cancer Res., 64: 9172-9179.
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  75. Andrei, C., P. Margiocco, A. Poggi, L.V. Lotti, M.R. Torrisi and A. Rubartelli, 2004. Phospholipases C and A2 control lysosome-mediated IL-1β secretion: Implications for inflammatory processes. Proc. Nat. Acad. Sci. USA., 101: 9745-9750.
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  76. Spaggiari, G.M., P. Contini, S. Negrini, A. Dondero and R. Carosio et al., 2003. IFN-γ production in human NK cells through the engagement of CD8 by soluble or surface HLA class I molecules. Eur. J. Immunol., 33: 3049-3059.
    CrossRef  |  PubMed  |  Direct Link  |  

  77. Spaggiari, G.M., P. Contini, M.R. Zocchi and A. Poggi, 2003. Interaction of solubile HLA-I antigens with either CD8 or activating isoform of the inhibitory Receptor Superfamily members induces apoptosis of human NK cells via FasL/Fas interaction. Res. Trends Immunol., 5: 33-43.

  78. Poggi, A., R. Carosio, D. Fenoglio, S. Brenci and G. Murdaca et al., 2003. Migration of Vδ1 and Vδ2 T cells in response to CXCR3 and CXCR4 ligands in healthy donors and HIV-1-infected patients: Competition by HIV-1 Tat. Blood, 103: 2205-2213.
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  79. Contini, P., M. Ghio, A. Poggi, G. Filaci, F. Indiveri, S. Ferrone and P. Puppp, 2003. Soluble HLA-A,-B,-C and -G molecules induce apoptosis in T and NK CD8+ cells and inhibit cytotoxic T cell activity through CD8 ligation. Eur. J. Immunol., 33: 125-134.
    CrossRef  |  PubMed  |  Direct Link  |  

  80. Spaggiari, G.M., P. Contini, R. Carosio, M. Arvigo and M. Ghio et al., 2002. Soluble HLA class I molecules induce natural killer cell apoptosis through the engagement of CD8: Evidence for a negative regulation exerted by members of the inhibitory receptor superfamily. Blood, 99: 1706-1714.
    CrossRef  |  PubMed  |  Direct Link  |  

  81. Spaggiari, G.M., P. Contini, A. Dondero, R. Carosio, F. Puppo, F. Indiveri, M.R. Zocchi and A. Poggi, 2002. Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-activating HLA class I receptors through FasL-Fas interaction. Blood, 100: 4098-4107.
    CrossRef  |  PubMed  |  Direct Link  |  

  82. Poggi, A., R. Carosio, G.M. Spaggiari, C. Fortis and G. Tambussi et al., 2002. NK cell activation by dendritic cells is dependent on LFA-1-mediated induction of calcium-calmodulin kinase II: Inhibition by HIV-1 Tat C-terminal domain. J. Immunol., 168: 95-101.
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  83. Poggi, A., R. Carosio, A. Rubartelli and M.R. Zocchi, 2002. β3-mediated engulfment of apoptotic tumor cells by dendritic cells is dependent on CAMKII: Inhibition by HIV-1 Tat. J. Leukoc Biol., 71: 531-537.
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  84. Poggi, A., M.R. Zocchi, R. Carosio, E. Ferrero and D.F. Angelini et al., 2002. Transendothelial migratory pathways of Vδ1+TCRγδ+ and Vδ2+TCRγδ+ T lymphocytes from healthy donors and multiple sclerosis patients: Involvement of phosphatidylinositol 3 kinase and calcium calmodulin-dependent kinase II. J. Immunol., 168: 6071-6077.
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  86. Ferrarini, M., E. Ferrero, L. Dagna, A. Poggi and M.R. Zocchi, 2002. Human γδ T cells: A nonredundant system in the immune-surveillance against cancer. Trends Immunol., 23: 14-18.
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  87. Zocchi, M.R., F. Pellegatta, I. Pierri, M. Gobbi and A. Poggi, 2001. Leukocyte-associated Ig-like receptor-1 prevents granulocyte-monocyte colony stimulating factor-dependent proliferation and Akt1/PKB alpha activation in primary acute myeloid leukemia cells. Eur. J. Immunol., 31: 3667-3675.
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  88. Spaggiari, G.M., R. Carosio, D. Pende, S. Marcenaro and P. Rivera et al., 2001. NK cell-mediated lysis of autologous antigen-presenting cells is triggered by the engagement of the phosphatidylinositol 3-kinase upon ligation of the natural cytotoxicity receptors NKp30 and NKp46. Eur. J. Immunol., 31: 1656-1665.
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  89. Gardella, S., C. Andrei, L.V. Lotti, A. Poggi, M.R. Torrisi, M.R. Zocchi and A. Rubartelli, 2001. CD8+ T lymphocytes induce polarized exocytosis of secretory lysosomes by dendritic cells with release of interleukin-1β and cathepsin D. Blood, 98: 2152-2159.
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  90. Poggi, A., G.M. Spaggiari, S. Quintino, M. Setti and I. Pierri et al., 2000. Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed prevents proliferation and induces apoptosis in human acute myeloid leukemias. Haematologica, 85: 54-54.

  91. Poggi, A., F. Pellegatta, B.E. Leone, L. Moretta and M.R. Zocchi, 2000. Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-κB nuclear translocation in human myeloid leukemias. Eur. J. Immunol., 30: 2751-2758.
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  92. Gardella, S., C. Andrei, A. Poggi, M.R. Zocchi and A. Rubartelli, 2000. Control of interleukin-18 secretion by dendritic cells: Role of calcium influxes. FEBS Lett., 481: 245-248.
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  93. Ferrero, E., K. Vettoretto, A. Bondanza, A. Villa, M. Resnati, A. Poggi and M.R. Zocchi, 2000. uPA/uPAR system is active in immature dendritic cells derived from CD14+CD34+ precursors and is down-regulated upon maturation. J. Immunol., 164: 712-718.
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  94. Rubartelli, A., A. Poggi, R. Sitia and M.R. Zocchi, 1999. Reply to reinhold et al. Immunol. Today, 20: 384-385.
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  95. Poggi, A., M.R. Zocchi, P. Costa, E. Ferrero and G. Borsellino et al., 1999. IL-12-mediated NKRP1A up-regulation and consequent enhancement of endothelial transmigration of Vδ 2+ TCRγδ+ T lymphocytes from healthy donors and multiple sclerosis patients. J. Immunol., 162: 4349-4354.
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  96. Gardella, S., C. Andrei, S. Costigliolo, A. Poggi, M.R. Zocchi and A. Rubartelli, 1999. Interleukin-18 synthesis and secretion by dendritic cells are modulated by interaction with antigen-specific T cells. J. Leukoc. Biol., 66: 237-241.
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  97. Zocchi, M.R., A. Rubartelli, P. Morgavi and A. Poggi, 1998. HIV-1 Tat inhibits human natural killer cell function by blocking L-type calcium channels. J. Immunol., 161: 2938-2943.
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  98. Rubartelli, A., A. Poggi, R. Sitia and M.R. Zocchi, 1998. HIV-1 Tat: A polypeptide for all seasons. Immunol. Today, 19: 543-545.
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  99. Poggi, A., P. Costa, E. Tomasello and L. Moretta, 1998. IL-12-induced up-regulation of NKRP1A expression in human NK cells and consequent NKRP1A- mediated down-regulation of NK cell activation. Eur. J. Immunol., 28: 1611-1616.
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  100. Poggi, A., E. Tomasello, E. Ferrero, M.R. Zocchi and L. Moretta, 1998. p40/LAIR-1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte-monocyte colony-stimulating factor. Eur. J. Immunol., 28: 2086-2091.
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  101. Poggi, A., A. Rubartelli and M.R. Zocchi, 1998. Involvement of dihydropyridine-sensitive calcium channels in human dendritic cell function. Competition by HIV-1 Tat. J. Biol. Chem., 273: 7205-7209.
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  102. Ferrero, E., M. Fabbri, A. Poggi, G. Galati, S. Bernasconi and M.R. Zocchi, 1998. Tumor-driven matrix invasion by infiltrating lymphocytes: Involvement of the α1 integrin I-domain. Eur. J. Immunol., 28: 2530-2536.
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  103. Ferrero, E., A. Bondanza, B.E. Leone, S. Manici, A. Poggi and M.R. Zocchi, 1998. CD14+ CD34+ peripheral blood mononuclear cells migrate across endothelium and give rise to immunostimulatory dendritic cells. J. Immunol., 160: 2675-2683.
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  104. Zocchi, M.R., A. Poggi and A. Rubartelli, 1997. The RGD-containing domain of exogenous HIV-1 Tat inhibits the engulfment of apoptotic bodies by dendritic cells. AIDS, 11: 1227-1235.
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  105. Rubartelli, A., A. Poggi and M.R. Zocchi, 1997. The selective engulfment of apoptotic bodies by dendritic cells is mediated by the αvβ3 integrin and requires intracellular and extracellular calcium. Eur. J. Immunol., 27: 1893-1900.
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  106. Poggi, A., P. Costa, M.R. Zocchi and L. Moretta, 1997. Phenotypic and functional analysis of CD4+ NKRP1A+ human T lymphocytes. Direct evidence that the NKRP1A molecule is involved in transendothelial migration. Eur. J. Immunol., 27: 2345-2350.
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  107. Poggi, A., P. Costa, M.R. Zocchi and L. Moretta, 1997. NKRP1A molecule is involved in transendothelial migration of CD4+ human T lymphocytes. Immunol. Lett., 57: 121-123.
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  108. Poggi, A., E. Tomasello, V. Revello, L. Nanni, P. Costa and L. Moretta, 1997. p40 molecule regulates NK cell activation mediated by NK receptors for HLA class I antigens and TCR-mediated triggering of T lymphocytes. Int. Immunol., 9: 1271-1279.
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  109. Poggi, A., E. Tomasello and P. Costa, 1997. NKRP1A and p40 molecules are involved in regulation of activation and maturation of human NK cells. Res. Immunol., 148: 179-184.
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  110. Poggi, A., A. Rubartelli, L. Moretta and M.R. Zocchi, 1997. Expression and function of NKRP1A molecule on human monocytes and dendritic cells. Eur. J. Immunol., 27: 2965-2970.
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  111. Moretta, L., A. Poggi, L. Nanni, C. Bottino, G. Melioli, R. Biassoni and A. Moretta, 1997. Natural Killer Cell Antigens: Section Report. In: Leukocyte Typing VI, Kishimoto, T. (Ed.). Garland Publishing, New York, pp: 265-267.

  112. Moretta, A., R. Biassoni, C. Bottino, D. Pende and M. Vitale et al., 1997. Major histocompatibility complex class I-specific receptors on human natural killer and T lymphocytes. Immunol. Rev., 155: 105-117.
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  113. Davodeau, F., M.A. Peyrat, A. Necker, R. Dominici and F. Blanchard et al., 1997. Close phenotypic and functional similarities between human and murine αβ T cells expressing invariant TCR α-chains. J. Immunol., 158: 5603-5611.
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  114. Poggi, A., P. Costa, L. Morelli, C. Cantoni and N. Pella et al., 1996. Expression of human NKRP1A by CD34+ immature thymocytes: NKRP1A-mediated regulation of proliferation and cytolytic activity. Eur. J. Immunol., 26: 1266-1272.
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  115. Poggi, A., N. Pella, C. Cantoni, M.R. Zocchi and L. Moretta, 1996. Physical and functional association of CD45 and CD3-TCR complex on CD1+ human thymocytes. Evidence that the engagement of CD45 molecules can prevent CD1+ thymocytes from apoptosis. Int. Immunol., 8: 1947-1953.
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  116. Poggi, A., M.C. Panzeri, L. Moretta and M.R. Zocchi, 1996. CD31-triggered rearrangement of the actin cytoskeleton in human natural killer cells. Eur. J. Immunol., 26: 817-824.
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  117. Poggi, A., F. Spada, P. Costa, E. Tomasello and V. Revello et al., 1996. Dissection of lymphocyte function-associated antigen 1-dependent adhesion and signal transduction in human natural killer cells shown by the use of cholera or pertussis toxin. Eur. J. Immunol., 26: 967-975.
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  118. Mingari, M.C., A. Cambiaggi, C. Vitale, F. Schiavetti, R. Bellomo and A. Poggi, 1996. Effect of superantigens on human thymocytes: Selective proliferation of V beta 2+ cells in response to toxic shock syndrome toxin-1 and their deletion upon secondary stimulation. Int. Immunol., 8: 203-209.
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  119. Han, D., C. Pottin-Clemenceau, M.A. Imro, M. Scudeletti and C. Doucet et al., 1996. IL2 triggers a tumor progression process in a melanoma cell line MELP derived from a patient whose metastasis increased in size during IL2/INFα biotherapy. Oncogene, 12: 1015-1023.
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  120. Biassoni, R., C. Cantoni, M. Falco, S. Verdiani and C. Bottino et al., 1996. The human leukocyte antigen (HLA)-C-specific ''activatory'' or ''inhibitory'' natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions. J. Exp. Med., 183: 645-650.
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  121. Zocchi, M.R. and A. Poggi, 1995. Human gamma delta T lymphocytes use N-CAM to interact with the subendothelial matrix. J. Natl. Cancer Inst., 87: 846-847.
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  122. Poggi, A., N. Pella, L. Morelli, F. Spada and V. Revello, et al., 1995. P40, a novel surface molecule involved in the regulation of the non-major histocompatibility complex-restricted cytolytic activity in humans. Eur. J. Immunol., 25: 369-376.
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  123. Poggi, A. and M.C. Mingari, 1995. Development of human NK cells from the immature cell precursors. Semin. Immunol., 7: 61-66.
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  124. Mingari, M.C., C. Vitale, A. Cambiaggi, F. Schiavetti, G. Melioli, S. Ferrini and A. Poggi, 1995. Cytolytic T lymphocytes displaying natural killer (NK)-like activity: expression of NK-related functional receptors for HLA class I molecules (p58 and CD94) and inhibitory effect on the TCR-mediated target cell lysis or lymphokine production. Int. Immunol., 7: 697-703.
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  125. Zocchi, M.R., E. Ferrero, E. Toninelli, P. Castellani, A. Poggi and C. Rugarli, 1994. Expression of N-CAM by human renal cell carcinomas correlates with growth rate and adhesive properties. Exp. Cell Res., 214: 499-509.
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  126. Poggi, A., J.F. Demarest, P. Costa, R. Biassoni and N. Pella et al., 1994. Expression of a wide T cell receptor V beta repertoire in human T lymphocytes derived in vitro from embryonic liver cell precursors. Eur. J. Immunol., 24: 2258-2261.
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  127. Moretta, L., E. Ciccone, A. Poggi, M.C. Mingari and A. Moretta, 1994. Origin and functions of human natural killer cells. Int. J. Clin. Lab. Res., 24: 181-186.
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  128. Moretta, L., E. Ciccone, A. Poggi, M.C. Mingari and A. Moretta, 1994. Ontogeny, specific functions and receptors of human natural killer cells. Immunol. Lett., 40: 83-88.
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  129. Ferrini, S., S. Sforzini, A. Cambiaggi, A. Poggi and R. Meazza, et al., 1994. The LFA-1/ICAM cell adhesion pathway is involved in tumor-cell lysis mediated by bispecific monoclonal-antibody-targeted T lymphocytes. Int. J. Cancer, 56: 846-852.
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  130. Cantoni, C., A. Cambiaggi, S. Sforzini, A. Poggi, M. Viale, R. Biassoni and S. Ferrini, 1994. Characterization of a cyclosporin A-sensitive activation pathway in cultured T and natural killer cells. Scand J. Immunol., 39: 373-379.
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  131. Zocchi, M.R., M. Vidal and A. Poggi, 1993. Involvement of CD56/N-CAM molecule in the adhesion of human solid tumor cell lines to endothelial cells. Exp. Cell. Res., 204: 130-135.
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  132. Zocchi, M.R., A. Poggi, F. Crosti, S. Tongiani and C. Rugarli, 1993. Signal transduction in human tumor infiltrating lymphocytes. Arch. Immunol. Ther. Exp. (Warsz), 41: 33-39.
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  133. Zocchi, M.R. and A. Poggi, 1993. NCAM and lymphocyte adhesion in leucocyte adhesion deficiency (LAD) syndrome. Immunol. Today, 14: 94-95.
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  134. Zocchi, M.R. and A. Poggi, 1993. Lymphocyte-endothelial cell adhesion molecules at the primary tumor site in human lung and renal cell carcinomas. J. Natl. Cancer. Inst., 85: 246-247.
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  135. Tripodi, G., A. Poggi, A.M. Orengo, N. Pella and M. Vitale et al., 1993. Identification of a new surface molecule involved in the mechanism of cell to cell adhesion between human NK and tumor target cells. Cytotechnology, 1: S109-S111.
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  136. Poggi, A., R. Pardi, N. Pella, L. Morelli and S. Sivori et al., 1993. CD45-mediated regulation of LFA1 function in human natural killer cells. Anti-CD45 monoclonal antibodies inhibit the calcium mobilization induced via LFA1 molecules. Eur. J. Immunol., 23: 2454-2463.
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  137. Poggi, A., M. Sargiacomo, R. Biassoni, N. Pella and S. Sivori et al., 1993. Extrathymic differentiation of T lymphocytes and natural killer cells from human embryonic liver precursors. Proc. Natl. Acad. Sci. USA., 90: 4465-4469.
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  138. Zocchi, M.R., A. Poggi, F. Crosti, S. Tongiani and C. Rugarli, 1992. Signalling in human tumour infiltrating lymphocytes: The CD28 molecule is functional and is physically associated with the CD45R0 molecule. Eur. J. Cancer, 28: 749-754.
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  139. Zocchi, M.R. and A. Poggi, 1992. NCAM is Involved in the Adhesion of Human LFA1 Negative Thymic and Peripheral Lymphocytes to Endothelial Cells. In: Recent Advances in Cellular and Molecular Biology, Wegmann, R.J. and M.A. Wegmann (Eds.). Peeters Press, Leuven, Belgium, pp: 121-127.

  140. Vidal, M.J., M.R. Zocchi, A. Poggi, F. Pellegatta and S.L. Chierchia, 1992. Involvement of nitric oxide in tumor cell adhesion to cytokine-activated endothelial cells. J. Cardiovasc. Pharmacol., 12: S155-S159.
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  141. Poggi, A., 1992. The Leukocyte Common Antigen Regulates The [Ca++]I Increase Mediated Via the Lymphocyte Function Associated Antigen-1 in CD3-CD16+ Peripheral Lymphocytes. In: Recent Advances in Cellular and Molecular Biology, Wegmann, R.J. and M.A. Wegmann (Eds.). Peeters Press, Leuven, Belgium, pp: 63-69.

  142. Poggi, A. and M.R. Zocchi, 1992. Cultured human thymocytes lacking CD2 and CD11a/CD18 antigens are functional and adhere to endothelial cells via CD56 or CDw49d molecules. Cell Immunol., 140: 319-330.
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  143. Poggi, A. and M.R. Zocchi, 1992. Antigen-independent pathways of T-cell activation are functional in human immature thymocytes. Int. J Clin. Lab. Res., 21: 304-309.
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  144. Mingari, M.C., A. Poggi, R. Bellomo, N. Pella and L. Moretta, 1992. Thymic origin of some natural killer cells: clonal proliferation of human CD3-16+ cells from CD3-4-8- thymocyte precursors requires the presence of H9 leukemic cells. Int. J. Clin. Lab. Res., 21: 176-178.
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  145. Zocchi, M.R., M. Fabbri, A. Poggi and E. Gianazza, 1991. Biochemical characterization by two-dimensional electrophoresis of lymphocyte antigens involved in cell-to-cell or cell-to-matrix adhesion. Electrophoresis, 12: 527-535.
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  146. Zocchi, M.R. and A. Poggi, 1991. Activation of CD3/TCR negative human thymocytes via CD28 molecule. Cell Immunol., 136: 105-112.
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  147. Moretta, A., A. Poggi, D. Pende, G. Tripodi and A.M. Orengo et al., 1991. CD69-mediated pathway of lymphocyte activation: Anti-CD69 monoclonal antibodies trigger the cytolytic activity of different lymphoid effector cells with the exception of cytolytic T lymphocytes expressing T cell receptor alpha/beta. J. Exp. Med., 174: 1393-1398.
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  148. Mingari, M.C., A. Poggi, R. Biassoni, R. Bellomo and E. Ciccone et al., 1991. In vitro proliferation and cloning of CD3- CD16+ cells from human thymocyte precursors. J. Exp. Med., 174: 21-26.
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  149. Zocchi, M.R., F. Marelli and A. Poggi, 1990. Simultaneous cytofluorometric analysis for the expression of cytoplasmic antigens and DNA content in CD3- human thymocytes. Cytometry, 11: 883-887.
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  150. Zocchi, M.R., A. Poggi, S. Heltai, A. Villa and L. Inverardi et al., 1990. Signal requirements for activation of leukaemic T cells from a chronic lymphocytic leukaemia (T-CLL). Clin. Exp. Immunol., 82: 108-113.
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  151. Zocchi M.R., F. Marelli and A. Poggi, 1990. CD1+ thymocytes proliferate and give rise to functional cells after stimulation with monoclonal antibodies recognizing CD3, CD2 or CD28 surface molecules. Cell Immunol, 129: 394-403.
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  152. Poggi, A., R. Biassoni, N. Pella, F. Paolieri and R. Bellomo et al., 1990. In vitro expansion of CD3/TCR- human thymocyte populations that selectively lack CD3 delta gene expression: A phenotypic and functional analysis. J. Exp. Med., 172: 1409-1418.
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  153. Poggi, A., E. Maggi, R. Biagiotti, M.G. Giudizi and F. Almerigogna et al., 1990. A novel pathway of human B cell activation initiated by CK226 surface antigen. Eur. J. Immunol., 20: 1161-1165.
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  154. Heltai, S., A. Poggi, M.G. Sabbadini and M.R. Zocchi, 1990. Evaluation of cytotoxic cell-target cell conjugates. Comparison between flow cytometric analysis and 51Cr binding assay. Haematologica, 75: 191-193.
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  155. Ferrarini, M., E. Ferrero, C. Fortis, A. Poggi and M.R. Zocchi, 1990. LAK1 antigen defines two distinct subsets among human tumour infiltrating lymphocytes. Br. J. Cancer, 62: 754-757.
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  156. De Maria, A.F., M.S. Malnati, A. Poggi, D. Pende, F. Cottafava and L. Moretta, 1990. Clonal analysis of joint fluid T lymphocytes in patients with juvenile rheumatoid arthritis. J. Rheumatol., 17: 1073-1078.
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  157. Zocchi, M.R., S. Heltai and A. Poggi, 1989. Dual-parameter flow cytometric analysis of an early lymphocyte activation antigen (CK226) and DNA content. Cytometry, 10: 762-771.
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  158. Zocchi, M.R., A. Poggi, S. Mariani, E. Gianazza and C. Rugarli, 1989. Identification of a new surface molecule expressed by human LGL and LAK cells: Production of a specific monoclonal antibody and comparison with other NK/LAK markers. Cell. Immunol., 124: 144-157.
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  159. Zocchi, M.R. and A. Poggi, 1989. LAK1 and LAK2 Monoclonal Antibodies Identified two different Molecules Expressed on Large Granular Lymphocytes and Lymphokine Activated Killer Cells. In: Leukocyte Typing IV, Knapp, W. (Ed.). Oxford University Press, Oxford, UK., pp: 727-728.

  160. Poggi, A., M.R. Zocchi, L. Moretta and A. Moretta, 1989. CK226: A novel surface molecule involved in human T cell activation. Eur. J. Immunol., 19: 2069-2074.
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  161. Poggi, A. and M.R. Zocchi, 1989. Activation and Proliferation of Human T and B Lymphocytes through a Novel Surface Structure Defined by the Monoclonal Antibody CK226. In: Leukocyte Typing IV, Knapp, W. (Ed.). Oxford University Press, Oxford, UK., pp: 375-376.

  162. Pantaleo, G., M.R. Zocchi, S. Ferrini, A. Poggi and G. Tambussi et al., 1988. Human cytolytic cell clones lacking surface expression of T cell receptor alpha/beta or gamma/delta. Evidence that surface structures other than CD3 or CD2 molecules are required for signal transduction. J. Exp. Med., 168: 13-24.
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  163. Poggi, A., C. Bottino, M.R. Zocchi, G. Pantaleo and E. Ciccone et al., 1987. CD3+ WT31 peripheral T lymphocytes lack T44 (CD28), a surface molecule involved in activation of T cells bearing the α/β heterodimer. Eur. J. Immunol., 17: 1065-1068.
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  164. Pantaleo, G., D. Olive, M.R. Zocchi, A. Poggi, C. Bottino and A. Moretta, 1987. Signal Transducing Mechanisms in Human T Cell Activation. In: Genotypic and Functional Aspects of Haematopoiesis, Grignani, F., M.F. Martelli and D.Y. Mason (Eds.). Raven Press, New York, USA., pp: 197-204.

  165. Pantaleo, G., D. Olive, A. Poggi, W.J. Kozumbo, L. Moretta and A. Moretta, 1987. Transmembrane signalling via the T11-dependent pathway of human T cell activation. Evidence for the involvement of 1,2-diacylglycerol and inositol phosphates. Eur. J. Immunol., 17: 55-60.
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