Dr. Emanuela  Masini

Dr. Emanuela Masini

Professor
University of Florence, Italy


Highest Degree
M.D. in Medicine from University of Florence, Italy

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Area of Interest:

Biomedical Sciences
100%
Autacoids
62%
Endocrinology
90%
Cannabinoids
75%
Physiology
55%

Education

2006

M.D.

University of Florence, Italy

Medicine

Selected Publications

  1. Somma, T., L. Cinci, G. Formicola, A. Pini and R. Thurmond et al., 2013. A selective antagonist of histamine H4 receptors prevents antigen-induced airway inflammation and bronchoconstriction in guinea pigs: Involvement of lipocortin-1. Br. J. Pharmacol., 170: 200-213.
    CrossRef  |  

  2. Mondovi, B., W.A. Fogel, R. Federico, C. Calinescu, M.A. Mateescu, A.C. Rosa and E. Masini, 2013. Effects of amine oxidases in allergic and Histamine-mediated conditions. Recent Patents Inflammat. Allergy Drug Discovery, 7: 20-34.
    CrossRef  |  

  3. Masini, E., F. Carta, A. Scozzafava and C.T. Supuran, 2013. Antiglaucoma carbonic anhydrase inhibitors: A patent review. Expert Opin. Ther. Pat., 23: 705-716.
    CrossRef  |  

  4. Collino, M., A. Pini, N. Mugelli, R. Mastroianni and D. Bani et al., 2013. Beneficial effect of prolonged heme oxygenase-1 activation in a rat model of chronic heart failure. Dis. Models Mech., 10.1242/dmm.011528.
    CrossRef  |  

  5. Carta, F., A. Akdemir, A. Scozzafava, E. Masini and C.T. Supuran, 2013. Xanthates and trithiocarbonates strongly inhibit carbonic anhydrases and show antiglaucoma effects in vivo. J. Med. Chem., 56: 4691-4700.
    CrossRef  |  

  6. Tarquini, R., E. Masini, G. la Villa, G. Mazzoccoli and R. Mastroianni et al., 2012. Hepato-systemic gradient of carbon monoxide in cirrhosis. Eur. J. Internal Med., 23: e14-e18.
    CrossRef  |  

  7. Pini, A., S. Viappiani, M. Bolla, E. Masini and D. Bani, 2012. Prevention of Bleomycin-induced lung fibrosis in mice by a novel approach of parallel inhibition of cyclooxygenase and nitric-oxide donation using NCX 466, a prototype cyclooxygenase inhibitor and nitric-oxide donor. J. Pharmacol. Exp. Ther., 341: 493-499.
    CrossRef  |  

  8. Pini, A., G. Mannaioni, D. Pellegrini-Giampietro, M. Beatrice Passani, R. Mastroianni, D. Bani and E. Masini, 2012. The role of cannabinoids in inflammatory modulation of allergic respiratory disorders, inflammatory pain and ischemic stroke. Current Drug Targets, 13: 984-993.
    CrossRef  |  

  9. Impagnatiello, F., B. Giambene, C. Lanzi, A. Pini and T. Somma et al., 2012. The nitric oxide donating triamcinolone acetonide NCX 434 does not increase intraocular pressure and reduces endothelin-1 induced biochemical and functional changes in the rabbit eye. Br. J. Ophthalmol., 96: 757-761.
    CrossRef  |  

  10. Failli, P., A. Vannacci, L.D.C. Mannelli, R. Motterlini and E. Masini, 2012. Relaxant effect of a water soluble carbon Monoxide-releasing molecule (CORM-3) on spontaneously hypertensive rat aortas. Cardiovascular Drugs Therapy, 26: 285-292.
    CrossRef  |  

  11. Fabrizi, F., F. Mincione, T. Somma, G. Scozzafava and F. Galassi et al., 2012. A new approach to antiglaucoma drugs: carbonic anhydrase inhibitors with or without NO donating moieties. Mechanism of action and preliminary pharmacology. J. Enzyme Inhibit. Med. Chem., 27: 138-147.
    CrossRef  |  

  12. Carta, F., M. Aggarwal, A. Maresca, A. Scozzafava, R. McKenna, E. Masini and C.T. Supuran, 2012. Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo. J. Med. Chem., 55: 1721-1730.
    CrossRef  |  

  13. Triadafilopoulos, G., A. Taddei, P. Bechi, G. Freschi and M.N. Ringressi et al., 2011. Barrett's esophagus: Proton pump inhibitors and chemoprevention I. Annals N. Y. Acad. Sci., 1232: 93-113.
    CrossRef  |  

  14. Richter, J.E., R. Penagini, D. Pohl, K. Dvorak and A. Goldman et al., 2011. Barrett's esophagus: Proton pump inhibitors and chemoprevention II. Ann. N. Y. Acad. Sci., 1232: 114-139.
    CrossRef  |  Direct Link  |  

  15. Mincione, F., F. Benedini, S. Biondi, A. Cecchi and C. Temperini et al., 2011. Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action. Bioorganic Med. Chem. Lett., 21: 3216-3221.
    CrossRef  |  

  16. Cinci, L., E. Masini, A. Bencini, B. Valtancoli, R. Mastroianni, L. Calosi and D. Bani, 2010. Suppression of allergen-induced respiratory dysfunction and airway inflammation in sensitized guinea pigs by MnII(Me2DO2A), a novel superoxide scavenger compound. Free Radical Biol. Med., 48: 1525-1534.
    CrossRef  |  

  17. Cianchi, F., S. Cuzzocrea, M.C. Vinci, L. Messerini and C.E. Comin et al., 2010. Heterogeneous expression of cyclooxygenase-2 and inducible nitric oxide synthase within colorectal tumors: Correlation with tumor angiogenesis. Digestive Liver Dis., 42: 20-27.
    CrossRef  |  

  18. Cianchi, F., M.C. Vinci, C.T. Supuran, B. Peruzzi and P. de Giuli et al., 2010. Selective inhibition of carbonic anhydrase IX decreases cell proliferation and induces ceramide-mediated apoptosis in human cancer cells. J. Pharmacol. Exp. Ther., 334: 710-719.
    CrossRef  |  Direct Link  |  

  19. Chen, Z., C. Muscoli, T. Doyle, L. Bryant and S. Cuzzocrea et al., 2010. NMDA-receptor activation and nitroxidative regulation of the glutamatergic pathway during nociceptive processing. Pain, 149: 100-106.
    CrossRef  |  

  20. Tarquini, R., E. Masini, G. la Villa, G. Barletta and M. Novelli et al., 2009. Increased plasma carbon monoxide in patients with viral cirrhosis and hyperdynamic circulation. Am. J. Gastroenterol., 104: 891-897.
    CrossRef  |  Direct Link  |  

  21. Perrino, E., C. Uliva, C. Lanzi, P.D. Soldato, E. Masini and A. Sparatore, 2009. New prostaglandin derivative for glaucoma treatment. Bioorganic Med. Chem. Lett., 19: 1639-1642.
    CrossRef  |  

  22. Ndengele, M.M., S. Cuzzocrea, E. Masini, M.C. Vinci and E. Esposito et al., 2009. Spinal ceramide modulates the development of morphine antinociceptive tolerance via peroxynitrite-mediated nitroxidative stress and neuroimmune activation. J. Pharmacol. Exp. Ther., 329: 64-75.
    CrossRef  |  Direct Link  |  

  23. Masini, E., E. Ragazzo, M.C. Vinci, S. Nistri and L. Cinci et al., 2009. A selective H 4 R antagonist prevents antigen-induced asthma-like reaction and airway inflammation in guinea pigs. Inflammat. Res., 58: 9-10.
    CrossRef  |  

  24. Manera, C., G. Saccomanni, B. Adinolfi, V. Benetti and A. Ligresti et al., 2009. Rational design, synthesis and pharmacological properties of new 1, 8-naphthyridin-2 (1 H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists. J. Med. Chem., 52: 3644-3651.
    CrossRef  |  

  25. Doyle, T., L. Bryant, I. Batinic-Haberle, J. Little and S. Cuzzocrea et al., 2009. Supraspinal inactivation of mitochondrial superoxide dismutase is a source of peroxynitrite in the development of morphine antinociceptive tolerance. Neuroscience, 164: 702-710.
    CrossRef  |  

  26. Collino, M., S. Castiglia, M. Manoni, L. Salsini, J. Chini, E. Masini and R. Fantozzi, 2009. Effects of a Semi-synthetic N-, O-sulfated glycosaminoglycan K5 polysaccharide derivative in a rat model of cerebral ischaemia/reperfusion injury. Thromb Haemost, 102: 837-845.

  27. Ceccarelli, M., D. Bani, L. Cinci, S. Nistri and C. Uliva et al., 2009. Anti-inflammatory effects of low molecular weight heparin derivative in a rat model of carrageenan-induced pleurisy. J. Cell. Mol. Med., 13: 2704-2712.
    CrossRef  |  

  28. Bryant, L., T. Doyle, Z. Chen, S. Cuzzocrea and E. Masini et al., 2009. Spinal ceramide and neuronal apoptosis in morphine antinociceptive tolerance. Neurosci. Lett., 463: 49-53.
    CrossRef  |  

  29. Nistri, S., L. Cinci, A.M. Perna, E. Masini, R. Mastroianni and D. Bani, 2008. Relaxin induces mast cell inhibition and reduces ventricular arrhythmias in a swine model of acute myocardial infarction. Pharmacol. Res., 57: 43-48.
    CrossRef  |  

  30. Masini, E., L. Giannini, S. Nistri, L. Cinci and R. Mastroianni et al., 2008. Ceramide: A key signaling molecule in a Guinea pig model of allergic asthmatic response and airway inflammation. J. Pharmacol. Exp. Ther., 324: 548-557.
    CrossRef  |  

  31. Masini, E., A. Vannacci, P. Failli, R. Mastroianni and L. Giannini et al., 2008. A carbon Monoxide-releasing molecule (CORM-3) abrogates polymorphonuclear Granulocyte-induced activation of endothelial cells and mast cells. FASEB J., 22: 3380-3388.
    CrossRef  |  

  32. Giannini, L., S. Nistri, R. Mastroianni, L. Cinci and A. Vannacci et al., 2008. Activation of cannabinoid receptors prevents Antigen-induced Asthma-like reaction in guinea pigs. J. Cell. Mol. Med., 12: 2381-2394.
    CrossRef  |  

  33. Cuzzocrea, S. and E. Masini, 2008. Plant histaminase as an investigational drug in splanchnic artery occlusion and reperfusion. Exp. Opin. Invest. Drugs, 17: 1151-1160.
    CrossRef  |  

  34. Cianchi, F., M.C. Vinci and E. Masini, 2008. Histamine in cancer: The dual faces of the coin. Cancer Biol. Ther., 7: 36-37.
    Direct Link  |  

  35. Vizzutti, F., R.G. Romanelli, U. Arena, L. Rega and M. Brogi et al., 2007. ADMA correlates with portal pressure in patients with compensated cirrhosis. Eur. J. Clin. Invest., 37: 509-515.
    CrossRef  |  

  36. Vannacci, A., L. Giannini, F. Fabrizi, C. Uliva and R. Mastroianni et al., 2007. Effects of the carbon monoxide releasing molecule CORM-3 in a coincubation model of rat mast cells with human neutrophils. Inflammation Res., 56: S13-S14.
    CrossRef  |  

  37. Masini, E., S. Cuzzocrea, D. Bani, E. Mazzon and C. Muja et al., 2007. Beneficial effects of a plant histaminase in a rat model of splanchnic artery occlusion and reperfusion. Shock, 27: 409-415.

  38. Luceri, C., L. Giannini, M. Lodovici, E. Antonucci, R. Abbate, E. Masini and P. Dolara, 2007. p-Coumaric acid, a common dietary phenol, inhibits platelet activity in vitro and in vivo. Br. J. Nutr., 97: 458-463.
    Direct Link  |  

  39. Giannini, L., R. Mastroianni, C. Mariottini, M.B. Passani, S. Nistri, P.F. Mannaioni and E. Masini, 2007. Activation of cannabinoid receptors reduces Allergen-induced oxidative stress damage during Asthma-like reaction in sensitised Guinea-pigs. Inflammation Res., 56: S11-S12.
    CrossRef  |  

  40. Giannini, L., A. Vannacci, A. Missanelli, R. Mastroianni, P.F. Mannaioni, F. Moroni and E. Masini, 2007. Amatoxin poisoning: A 15-year retrospective analysis and follow-up evaluation of 105 patients. Clin. Toxicol., 45: 539-542.
    Direct Link  |  

  41. Emanuela, M., B. Danielle, M. Cosimo, M.M. Alexandru, M.P. Francesco, F. Rodolfo and M. Bruno, 2007. Pea seedling histaminase as a novel therapeutic approach to anaphylactic and inflammatory disorders. Scient. World J., 7: 888-902.
    CrossRef  |  

  42. Carolina, M., C. Salvatore, M.N. Michael, M. Vincenzo and P. Frank et al., 2007. Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice. J. Clin. Invest., 117: 3530-3539.
    CrossRef  |  

  43. Bani, D., S. Nistri, L. Cinci, L. Giannini and M. Princivalle et al., 2007. A novel, simple bioactivity assay for relaxin based on inhibition of platelet aggregation. Regulatory Peptides, 144: 10-16.
    CrossRef  |  

  44. Vannacci, A., C. Ravaldi, L. Giannini, C.M. Rotella, E. Masini, C. Faravelli and V. Ricca, 2006. Increased nitric oxide production in eating disorders. Neurosci. Lett., 399: 230-233.
    CrossRef  |  

  45. Vannacci, A., C. Marzocca, L.A. Giannini, L. Mazzetti and S. Franchi-Micheli et al., 2006. Evaluation of the effects of a novel carbon monoxide releasing molecule (CORM-3) in an in vitro model of cardiovascular inflammation. 1. Histamine in allergy, inflammation, tissue growth and repair. Inflammation Res., 55: 5-6.
    CrossRef  |  

  46. Masini, E., S. Cuzzocrea, E. Mazzon, C. Muia, A. Vannacci, F. Fabrizi and D. Bani, 2006. Protective effects of relaxin in ischemia/reperfusion‐induced intestinal injury due to splanchnic artery occlusion. Br. J. Pharmacol., 148: 1124-1132.
    CrossRef  |  

  47. Mannaioni, P.F., A. Vannacci and E. Masini, 2006. Carbon monoxide: The bad and the good side of the coin, from neuronal death to anti-inflammatory activity. Inflammation Res., 55: 261-273.
    CrossRef  |  

  48. Galassi, F., E. Masini, B. Giambene, F., Fabrizi, C. Uliva, M. Bolla and E. Ongini, 2006. A topical nitric oxide-releasing dexamethasone derivative: Effects on intraocular pressure and ocular haemodynamics in a rabbit glaucoma model. Br. J. Ophthalmol., 90: 1414-1419.
    CrossRef  |  

  49. Franchi, A., D. Massi, M. Santucci, E. Masini and D.R. Degl'Innocenti et al., 2006. Inducible nitric oxide synthase activity correlates with lymphangiogenesis and vascular endothelial growth factor‐C expression in head and neck squamous cell carcinoma. J. Pathol., 208: 439-445.
    CrossRef  |  

  50. Cianchi, F., C. Cortesini, L. Magnelli, E. Fanti and L. Papucci et al., 2006. Inhibition of 5-lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon cancer cells. Mol. Cancer Therap., 5: 2716-2726.
    CrossRef  |  

  51. Cianchi, F., C. Cortesini, F. Perna, V. Fabbroni and C. Uliva et al., 2006. Prostaglandin E2 correlates with histamine production in human colorectal cancer. Inflammation Res., 55: 81-82.
    CrossRef  |  

  52. Bani, D., P.F. Mannaioni and E. Masini, 2006. Cardiac anaphylaxis: Pathophysiology and therapeutic perspectives. Curr. Allergy Asthma Rep., 6: 14-19.
    CrossRef  |  

  53. Bani, D., L. Giannini, A. Ciampa, E. Masini and Y. Suzuki et al., 2006. Epigallocatechin-3-gallate reduces allergen-induced asthma-like reaction in sensitized guinea pigs. J. Pharmacol. Exp. Therap., 317: 1002-1011.
    CrossRef  |  

  54. Perna, A.M., E. Masini, S. Nistri, V. Briganti and L. Chiappini et al., 2005. Novel drug development opportunity for relaxin in acute myocardial infarction: Evidences from a swine model. FASEB J., 19: 1525-1527.
    CrossRef  |  

  55. Perna, A., E. Masini, S. Nistri, T. Bani Sacchi, M. Bigazzi and D. Bani, 2005. Human recombinant relaxin reduces heart injury and improves ventricular performance in a swine model of acute myocardial infarction. Ann. N. Y. Acad. Sci., 1041: 431-433.
    CrossRef  |  

  56. Mollace, V., C. Muscoli, E. Masini, S. Cuzzocrea and D. Salvemini, 2005. Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors. Pharmacol. Rev., 57: 217-252.
    Direct Link  |  

  57. Mincione, F., M. Starnotti, E. Masini, L. Bacciottini and C. Scrivanti et al., 2005. Carbonic anhydrase inhibitors: Design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma. Bioorg. Med. Chem. Lett., 15: 3821-3827.
    CrossRef  |  

  58. Masini, E., V. Fabbroni, L. Giannini, A. Vannacci and L. Messerini et al., 2005. Histamine and histidine decarboxylase up-regulation in colorectal cancer: Correlation with tumor stage. Inflammation Res., 54: S80-S81.
    CrossRef  |  

  59. Masini, E., D. Bani, A. Vannacci, S. Pierpaoli and P.F. Mannaioni et al., 2005. Reduction of antigen-induced respiratory abnormalities and airway inflammation in sensitized guinea pigs by a superoxide dismutase mimetic. Free Radic. Biol. Med., 39: 520-531.
    CrossRef  |  

  60. Cianchi, F., C. Cortesini, N. Schiavone, F. Perna and L. Magnelli et al., 2005. The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer. Clin. Cancer Res., 11: 6807-6815.
    CrossRef  |  

  61. Bianchi, P., O. Kunduzova, E. Masini, C. Cambon and D. Bani et al., 2005. Oxidative stress by monoamine oxidase mediates receptor-independent cardiomyocyte apoptosis by serotonin and postischemic myocardial injury. Circulation, 112: 3297-3305.
    Direct Link  |  

  62. Wang, Z.Q., F. Porreca, S. Cuzzocrea, K. Galen and R. Lightfoot et al., 2004. A newly identified role for superoxide in inflammatory pain. J. Pharmacol. Exp. Ther., 309: 869-878.
    CrossRef  |  

  63. Vannacci, A., L. Giannini, M.B. Passani, A. Di Felice and S. Pierpaoli et al., 2004. The endocannabinoid 2-arachidonylglycerol decreases the immunological activation of Guinea pig mast cells: Involvement of nitric oxide and eicosanoids. J. Pharmacol. Exp. Therap., 311: 256-264.
    CrossRef  |  

  64. Suzuki, Y., E. Masini, C. Mazzocca, S. Cuzzocrea, A. Ciampa, H. Suzuki and D. Bani, 2004. Inhibition of poly (ADP-ribose) polymerase prevents allergen-induced asthma-like reaction in sensitized Guinea pigs. J. Pharmacol. Exp. Therap., 311: 1241-1248.
    CrossRef  |  

  65. Muscoli, C., V. Mollace, J. Wheatley, E. Masini, M. Ndengele, Z.Q. Wang and D. Salvemini, 2004. Superoxide-mediated nitration of spinal manganese superoxide dismutase: A novel pathway in N-methyl-D-aspartate-mediated hyperalgesia. Pain, 111: 96-103.
    CrossRef  |  

  66. Masini, E., S. Nistri, A. Vannacci, T.B. Sacchi, A. Novelli and D. Bani, 2004. Relaxin inhibits the activation of human neutrophils: involvement of the nitric oxide pathway. Endocrinology, 145: 1106-1112.
    CrossRef  |  

  67. Masini, E., A. Vannacci, L. Giannini, O. Befani and S. Nistri et al., 2004. Effect of a plant histaminase on asthmalike reaction induced by inhaled antigen in sensitized guinea pig. Eur. J. Pharmacol., 502: 253-264.
    CrossRef  |  

  68. Galassi, F., G. Renieri, A. Sodi, F. Ucci, L. Vannozzi and E. Masini, 2004. Nitric oxide proxies and ocular perfusion pressure in primary open angle glaucoma. Br. J. Ophthalmol., 88: 757-760.
    CrossRef  |  

  69. De Leval, X., M. Ilies, A. Casini, J.M. Dogne and A. Scozzafava et al., 2004. Carbonic anhydrase inhibitors: Synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity. J. Med. Chem., 47: 2796-2804.
    CrossRef  |  

  70. Dani, C., E. Masini, G. Bertini, A.M. di Felice and M. Pezzati et al., 2004. Role of heme oxygenase and bilirubin in oxidative stress in preterm infants. Pediatric Res., 56: 873-877.
    CrossRef  |  

  71. Cianchi, F., C. Cortesini, O. Fantappie, L. Messerini and I. Sardi et al., 2004. Cyclooxygenase-2 activation mediates the proangiogenic effect of nitric oxide in colorectal cancer. Clin. Cancer Res., 10: 2694-2704.
    CrossRef  |  

  72. Vannacci, A., R. Baronti, G. Zagli, C. Marzocca and S. Pierpaoli et al., 2003. Carbon monoxide modulates the response of human basophils to FcepsilonRI stimulation through the heme oxygenase pathway. Eur. J. Pharmacol., 465: 289-297.

  73. Vannacci, A., M.B. Passani, S. Pierpaoli, L. Giannini, P.F. Mannaioni and E. Masini, 2003. Nitric oxide modulates the inhibitory effect of cannabinoids on the immunological activation of guinea pig mast cells. Inflamm. Res., 52: 7-8.

  74. Vannacci, A., L. Giannini, E. Masini and P.F. Mannaioni, 2003. Cannabinoid-induced activation of ERK and AKT in mast cells may be mediated by intracellular NO production. J. Immunol., Vol. 171. .
    Direct Link  |  

  75. Pierpaoli, S., C. Marzocca, M.G. Bello, W. Schunack, P.F. Mannaioni and E. Masini, 2003. Histaminergic receptors modulate the coronary vascular response in isolated guinea pig hearts. Role of nitric oxide. Inflamm. Res., 52: 390-396.
    CrossRef  |  Direct Link  |  

  76. Mondovi, B., P. Pietrangeli, L. Morpurgo, E. Masini and R. Federico et al., 2003. Some new functions of amine oxidases. Inflammopharmacology, 11: 155-163.
    CrossRef  |  

  77. Masini, E., S. Pierpaoli, C. Marzocca, P.F. Mannaioni and P. Pietrangeli et al., 2003. Protective effects of a plant histaminase in myocardial ischaemia and reperfusion injury in vivo. Biochem. Biophys. Res. Commun., 309: 432-439.
    CrossRef  |  

  78. Masini, E., A. Vannacci, C. Marzocca, S. Pierpaoli and L. Giannini et al., 2003. Heme oxygenase-1 and the ischemia-reperfusion injury in the rat heart. Exp. Biol. Med., 228: 546-549.
    Direct Link  |  

  79. Marzocca, C., A. Vannacci, S. Cuzzocrea, D. Salvemini, P.F. Mannaioni and E. Masini, 2003. Effects of the SOD mimetic, M40403, on prostaglandin production in an in vivo model of ischemia and reperfusion in rat heart. Inflamm. Res., 52: 23-24.
    CrossRef  |  Direct Link  |  

  80. Gallo, O., N. Schiavone, L. Papucci, I. Sardi and L. Magnelli et al., 2003. Down-regulation of nitric oxide synthase-2 and cyclooxygenase-2 pathways by p53 in squamous cell carcinoma. Am. J. Pathol., 163: 723-732.
    CrossRef  |  Direct Link  |  

  81. Cianchi, F., C. Cortesini, O. Fantappie, L. Messerini and N. Schiavone et al., 2003. Inducible nitric oxide synthase expression in human colorectal cancer: Correlation with tumor angiogenesis. Am. J. Pathol., 162: 793-801.
    CrossRef  |  

  82. Vannacci, A., R. Baronti, E. Masini, C. Ravaldi and V. Ricca, 2002. Anorexia Nervosa and risk of sudden death. Am. J. Med., 112: 327-328.

  83. Vannacci, A., G. Zagli, C. Marzocca, S. Pierpaoli and M.B. Passani et al., 2002. Down-regulation by cannabinoids of the immunological activation of human basophils and guinea pig mast cells. Inflamm. Res., 51: 9-10.
    CrossRef  |  Direct Link  |  

  84. Masini, E., S. Cuzzocrea, E. Mazzon, C. Marzocca, P.F. Mannaioni and D. Salvemini, 2002. Protective effects of M40403, a selective superoxide dismutase mimetic, in myocardial ischaemia and reperfusion injury in vivo. Br. J. Pharmacol., 136: 905-917.
    CrossRef  |  

  85. Masini, E., G. Zagli, J.F. Ndisang, M. Solazzo, P.F. Mannaioni and D. Bani, 2002. Protective effect of relaxin in cardiac anaphylaxis: Involvement of the nitric oxide pathway. Br. J. Pharmacol., 137: 337-344.
    CrossRef  |  

  86. Masini, E., A. Vannacci, C. Marzocca, P. Francesco Mannaioni and O. Befani et al., 2002. A plant histaminase modulates cardiac anaphylactic response in guinea pig. Biochem. Biophys. Res. Commun., 296: 840-846.
    CrossRef  |  

  87. Gallo, O., E. Masini, B. Bianchi, L. Bruschini, M. Paglierani and A. Franchi, 2002. Prognostic significance of cyclooxygenase-2 pathway and angiogenesis in head and neck squamous cell carcinoma. Hum. Pathol., 33: 708-714.
    CrossRef  |  Direct Link  |  

  88. Franchi, A., O. Gallo, M. Paglierani, I. Sardi, L. Magnelli, E. Masini and M. Santucci, 2002. Inducible nitric oxide synthase expression in laryngeal neoplasia: Correlation with angiogenesis. Head Neck, 24: 16-23.
    CrossRef  |  Direct Link  |  

  89. Franchi, A., M. Santucci, E. Masini, I. Sardi, M. Paglierani and O. Gallo, 2002. Expression of matrix metalloproteinase 1, matrix metalloproteinase 2 and matrix metalloproteinase 9 in carcinoma of the head and neck. Cancer, 95: 1902-1910.
    CrossRef  |  

  90. Fantappie, O., E. Masini, I. Sardi, L. Raimondi and D. Bani et al., 2002. The MDR phenotype is associated with the expression of COX‐2 and iNOS in a human hepatocellular carcinoma cell line. Hepatology, 35: 843-852.
    CrossRef  |  

  91. Cuzzocrea, S., E. Mazzon, L. Dugo, I. Serraino and R. Di Paola et al., 2002. A role for superoxide in gentamicin-mediated nephropathy in rats. Eur. J. Pharmacol., 450: 67-76.
    CrossRef  |  Direct Link  |  

  92. Baronti, R., E. Masini, L. Bacciottini and P.F. Mannaioni, 2002. Differential effects of amphotericin B and liposomal amphotericin B on inflammatory cells in vitro. Inflamm. Res., 51: 259-264.
    CrossRef  |  

  93. Bani, D., R. Baronti, A. Vannacci, M. Bigazzi, T. Bani-Sacchi, P.F. Mannaioni and E. Masini, 2002. Inhibitory effects of relaxin on human basophils activated by stimulation of the FC receptor. The role of nitric oxide. Int. Immunopharmacol., 2: 1195-1204.

  94. Ndisang, J.F., R. Wang, A. Vannacci, C. Marzocca and O. Fantappie et al., 2001. Haeme oxygenase‐1 and cardiac anaphylaxis. Br. J. Pharmacol., 134: 1689-1696.
    CrossRef  |  

  95. Ndisang, J.F., R. Baronti, G. Cecere, E. Masini, D. Bani and P.F. Mannaioni, 2001. Relaxin generates nitric oxide and provides protection against cardiac anaphylaxis. Inflamm. Res., 50: 122-123.
    CrossRef  |  Direct Link  |  

  96. La Villa, G., G. Barletta, P. Pantaleo, R. Del Bene and F. Vizzutti et al., 2001. Hemodynamic, renal and endocrine effects of acute inhibition of nitric oxide synthase in compensated cirrhosis. Hepatology, 34: 19-27.
    CrossRef  |  

  97. Gallo, O., A. Franchi, L. Magnelli, I. Sardi and A. Vannacci et al., 2001. Cyclooxygenase-2 pathway correlates with VEGF expression in head and neck cancer. Implications for tumor angiogenesis and metastasis. Neoplasia, 3: 53-61.
    Direct Link  |  

  98. Cianchi, F., C. Cortesini, P. Bechi, O. Fantappie and L. Messerini et al., 2001. Up-regulation of cyclooxygenase 2 gene expression correlates with tumor angiogenesis in human colorectal cancer. Gastroenterology, 121: 1339-1347.
    CrossRef  |  

  99. Ndisang, J.F., M. Moncini, P. Gai, L. Berni, G. Cecere, E. Masini and P.F. Mannaioni, 2000. Induction of heme oxygenase provides protection against cardiac anaphylaxis. Inflamm. Res., 49: 76-77.
    CrossRef  |  Direct Link  |  

  100. Moncini, M., E. Masini, F. Gambassi and P.F. Mannaioni, 2000. Gamma-hydroxybutyric acid and alchol-related syndromes. Alcohol, 20: 1-7.

  101. Masini, E., D. Bani, I. Sardi, R. Baronti, T. Bani-Sacchi, M. Bigazzi and P.F. Mannaioni, 2000. Dual role of nitric oxide in myocardial ischemia-reperfusion. Inflamm. Res., 49: 78-79.
    CrossRef  |  Direct Link  |  

  102. Galassi, F., A. Sodi, F. Ucci, G. Renieri, B. Pieri and E. Masini, 2000. Ocular haemodynamics and nitric oxide in normal pressure glaucoma. Acta Ophthalmologica Scandinavica, 78: 37-38.
    CrossRef  |  

  103. Ndisang, J.F., P. Gai, L. Berni, C. Mirabella, R. Baronti, P.F. Mannaioni and E. Masini, 1999. Modulation of the immunological response of guinea pig mast cells by carbon monoxide. Immunopharmacology, 43: 65-73.
    CrossRef  |  

  104. Mirabella, C., R. Baronti, L.A. Berni, P. Gai, J.F. Ndisang, E. Masini and P.F. Mannaioni, 1999. Hemin and carbon monoxide modulate the immunological response of human basophils. Int. Arch. Allergy Immunol., 118: 259-260.
    CrossRef  |  

  105. Mirabella, C., J.F. Ndisang, L.A. Berni, P. Gai, E. Masini and P.F. Mannaioni, 1999. Modulation of the immunological activation of human basophils by carbon monoxide. Inflamm. Res., 48: 11-12.
    CrossRef  |  

  106. Masini, E., M. Fazi, R. Baronti, P.F. Mannaioni and P. Bechi, 1999. Role of nitric oxide and histamine in the reflux-related gastric mucosal injury in the rat. Inflamm. Res., 48: 102-103.
    CrossRef  |  

  107. Masini, E., D. Salvemini, J.F. Ndisang, P. Gai and L. Berni Et Al., 1999. Cardioprotective activity of endogenous and exogenous nitric oxide on ischaemia reperfusion injury in isolated guinea pig hearts. Inflamm. Res., 48: 561-568.
    CrossRef  |  

  108. Lorenzi, P., M. Marsili, S. Boncinelli, L.P. Fabbri and P. Fontanari et al., 1999. Searching for a general anaesthesia protocol for rapid detoxification from opioids. Eur. J. Anaesthesiol., 16: 719-727.
    CrossRef  |  

  109. Gallo, O., I. Sardi, E. Masini and A. Franchi, 1999. Relationship between p53 mutation and inducible nitric oxide synthase expression in human colorectal cancer. J. Natl. Cancer Inst., 91: 1509-1510.

  110. Masini, E., M.G. Di Bello, S. Raspanti, J.F. Ndisang, R. Baronti, P. Cappugi and P.F. Mannaioni, 1998. The role of histamine in platelet aggregation by physiological and immunological stimuli. Inflamm. Res., 47: 211-220.
    CrossRef  |  Direct Link  |  

  111. Gallo, O., I. Fini-Storchi, W.A. Vergari, E. Masini, L. Morbidelli, M. Ziche and A. Franchi, 1998. Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer. J. Natl. Cancer Inst., 90: 587-596.
    CrossRef  |  Direct Link  |  

  112. Di Bello, M.G., L. Berni, P. Gai, C. Mirabella and J.F. Ndisang et al., 1998. A regulatory role for carbon monoxide in mast cell function. Inflamm. Res., 47: 7-8.
    CrossRef  |  PubMed  |  Direct Link  |  

  113. Di Bello, M.G., E. Masini, C. Ioannides, F.J. Ndisang, S. Raspanti, T.B. Sacchi and P.F. Mannaioni, 1998. Histamine release from rat mast cells induced by the metabolic activation of drugs of abuse into free radicals. Inflamm. Res., 47: 122-130.
    CrossRef  |  PubMed  |  Direct Link  |  

  114. Bani, D., P. Failli, M.G. Bello, C. Thiemermann, T.B. Sacchi, M. Bigazzi and E. Masini, 1998. Relaxin activates the L-arginine-nitric oxide pathway in vascular smooth muscle cells in culture. Hypertension, 31: 1240-1247.
    CrossRef  |  

  115. Bani, D., E. Masini, M.G. Bello, M. Bigazzi and T.B. Sacchi, 1998. Relaxin protects against myocardial injury caused by ischemia and reperfusion in rat heart. Am. J. Pathol., 152: 1367-1376.
    PubMed  |  Direct Link  |  

  116. Masini, E., M.G. di Bello, P. Cappugi, L. Berni, C. Mirabella and P.F. Mannaioni, 1997. Platelet aggregation and platelet histamine release by immunological stimulation in atopic patients: Modulation by nitric oxide. Inflamm. Res., 46: S81-S82.
    CrossRef  |  Direct Link  |  

  117. Masini, E., D. Bani, M.G. Bello, M. Bigazzi, P.F. Mannaioni and T.B. Sacchi, 1997. Relaxin counteracts myocardial damage induced by ischemia-reperfusion in isolated guinea pig hearts: Evidence for an involvement of nitric oxide. Endocrinology, 138: 4713-4720.
    CrossRef  |  PubMed  |  Direct Link  |  

  118. Mannaioni, P.F., M.G. di Bello and E. Masini, 1997. Platelets and inflammation: Role of platelet-derived growth factor, adhesion molecules and histamine. Inflamm. Res., 46: 4-18.
    PubMed  |  Direct Link  |  

  119. Mannaioni, P.F., M.G. Bello, M.G. di Bello, W. Schunack and E. Masini, 1997. Histamine up-regulates the generation of nitric oxide and nitric oxide down-regulates the release of histamine in cardiovascular preparations. Inflamm. Res., 46: S97-S78.
    CrossRef  |  PubMed  |  Direct Link  |  

  120. Mannaioni, P.F., M.G. Bello, M.G. di Bello, C. Mirabella, P. Gai, W. Schunack and E. Masini, 1997. Interaction between histamine and nitric oxide in rat mast cells and in isolated guinea pig hearts. Int. Arch. Allergy Immunol., 113: 297-299.
    CrossRef  |  PubMed  |  Direct Link  |  

  121. Bani, D., L. Ballati, E. Masini, M. Bigazzi and T.B. Sacchi, 1997. Relaxin counteracts asthma-like reaction induced by inhaled antigen in sensitized guinea pigs. Endocrinology, 138: 1909-1915.
    CrossRef  |  PubMed  |  Direct Link  |  

  122. Masini, E., D. Salvemini, L. Mugnai, M.G. Bello, D. Bani and P.F. Mannaioni, 1996. The effectof relaxin on myocardial ischaemia-reperfusion injury and histamine release In vitro and In vivo. Inflamm. Res., 45: S27-S28.
    Direct Link  |  

  123. Mannaioni, P.F., M.G. di Bello, S. Raspanti, L. Mugnai, V. Romano and E. Masini, 1996. Free radical mediated release of histamine from rat mast cells induced by drugs of abuse. Inflamm. Res., 45: S25-S26.
    PubMed  |  Direct Link  |  

  124. Bechi, P., P. Romagnoli, S. Bacci, R. Dei, A. Amorosi, F. Cianchi and E. Masini, 1996. Helicobacter pylori and duodenal ulcer: Evidence for a histamine pathways-involving link. Am. J. Gastroenterol., 91: 2338-2343.
    PubMed  |  Direct Link  |  

  125. Masini, E., M.G. di Bello, D. Bani, M. Bigazzi, T.B. Sacchi and P.F. Mannaioni, 1995. Relaxin inhibits histamine release from mast cells: Involvement of nitric oxide production. Inflamm. Res., 44: S12-S13.
    CrossRef  |  PubMed  |  Direct Link  |  

  126. Masini, E., M. Lupini, L. Mugnai, S. Raspanti and P.F. Mannaioni, 1995. Polydeoxyribonucleotides and nitric oxide release from guinea-pig hearts during ischaemia and reperfusion. Br. J. Pharmacol., 115: 629-635.
    PubMed  |  Direct Link  |  

  127. Masini, E., L. Mugnai, M. Foschi, G. Laffi, P. Gentilini and P.F. Mannaioni, 1995. Changes in the production of nitric oxide and superoxide by inflammatory cells in liver cirrhosis. Int. Arch. Allergy Immunol., 107: 197-198.
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  128. Mannaioni, P.F., M.G. di Bello, S. Raspanti, V. Romano, T.B. Sacchi, P. Cappugi and E. Masini, 1995. Storage and release of histamine in human platelets. Inflamm. Res., 44: S16-S17.
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  129. Mannaioni, P.F., M.G. di Bello, S. Raspanti, L. Mugnai, V. Romano and E. Masini, 1995. Activation of xenobiotics into free radicals by prostaglandin-H-synthase and by rat liver microsomes. Adv. Prostaglandin Thromboxane Leukot Res., 23: 215-217.
    PubMed  |  Direct Link  |  

  130. Laffi, G., M. Foschi, E. Masini, A. Simoni and L. Mugnai et al., 1995. Increased production of nitric oxide by neutrophils and monocytes from cirrhotic patients with ascites and hyperdynamic circulation. Hepatology, 22: 1666-1673.
    CrossRef  |  PubMed  |  Direct Link  |  

  131. Di Bello, M.G., F. Gambassi, L. Mugnai, M. Lupini and T.B. Sacchi et al., 1995. Relaxin enhances the coronary outflow in perfused guinea-pig heart: Correlation with histamine and nitric oxide. Inflamm. Res., 44: S102-S103.
    CrossRef  |  PubMed  |  Direct Link  |  

  132. Bechi, P., P. Romagnoli, P. Panula, R. Dei, S. Bacci, A. Amorosi and E. Masini, 1995. Gastric mucosal histamine storing cells. Evidence for different roles of mast cells and enterochromaffin-like cells in humans. Dig. Dis. Sci., 40: 2207-2213.
    PubMed  |  Direct Link  |  

  133. Bani-Sacchi, T., M. Bigazzi, D. Bani, P.F. Mannaioni and E. Masini, 1995. Relaxin-induced increased coronary flow through stimulation of nitric oxide production. Br. J. Pharmacol., 116: 1589-1594.
    PubMed  |  Direct Link  |  

  134. Bani, D., M. Bigazzi, E. Masini, G. Bani and T.B. Sacchi, 1995. Relaxin depresses platelet aggregation: in vitro studies on isolated human and rabbit platelets. Lab. Invest., 73: 709-716.
    PubMed  |  Direct Link  |  

  135. Bani, D., E. Masini, M.G. Bello, M. Bigazzi and T.B. Sacchi, 1995. Relaxin activates the L-arginine-nitric oxide pathway in human breast cancer cells. Cancer Res., 55: 5272-5275.
    PubMed  |  Direct Link  |  

  136. Ziche, M., L. Morbidelli, E. Masini, S. Amerini and H.J. Granger et al., 1994. Nitric oxide mediates angiogenesis In vivo and endothelial cell growth and migration In vitro promoted by substance P. J. Clin. Invest., 94: 2036-2044.
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  137. Morbidelli, L., A. Parenti, E. Masini, H.J. Granger and M. Ziche, 1994. Effect of substance P and [Sar^9]-Sp-Sulfone on cyclic GMP accumulation in cultured coronary capillary endothelial cells. Neuropeptides, 26: 1-72.

  138. Masini, E., P. Bechi, R. Dei, M.G. di Bello and T.B. Sacchi, 1994. Helicobacter pylori potentiates histamine release from rat serosal mast cells induced by bile acids. Dig. Dis. Sci., 39: 1493-1500.
    CrossRef  |  Direct Link  |  

  139. Masini, E., M.G. di Bello, S. Raspanti, T.B. Sacchi, E. Maggi and P.F. Mannaioni, 1994. Platelet aggregation and histamine release by immunological stimuli. Immunopharmacology, 28: 19-29.
    CrossRef  |  PubMed  |  Direct Link  |  

  140. Masini, E., M.G. di Bello, L. Mugnani and P.F. Mannaioni, 1994. Anaphylaxis in human platelets. Br. J. Pharm., 111: 77P-77P.

  141. Masini, E., M.G. di Bello, A. Pistelli, S. Raspanti and F. Gambassi et al., 1994. Generation of nitric oxide from nitrovasodilators modulates the release of histamine from mast cells. J. Physiol. Pharmacol., 45: 41-53.
    PubMed  |  Direct Link  |  

  142. Masini, E., F. Gambassi, M.G. di Bello, L. Mugnai, S. Raspanti and P.F. Mannaioni, 1994. Nitric oxide modulates cardiac and mast cell anaphylaxis. Agents Actions, 41: C89-C90.
    CrossRef  |  PubMed  |  Direct Link  |  

  143. Masini, E., D. Bani, M. Bigazzi, P.F. Mannaioni and T. Bani-Sacchi, 1994. Effects of relaxin on mast cells. In vitro and In vivo studies in rats and guinea pigs. J. Clin. Invest., 94: 1974-1980.
    CrossRef  |  PubMed  |  Direct Link  |  

  144. Mannaioni, P.F., F. Gambassi, M.G. di Bello, P. Botti and L. Caramelli et al., 1994. Il gamma idrossibutirrato (GHB) nella medicina delle farmaco tossicodipendenze. Eur. J. Alcohol Stud., 4: 66-66.

  145. Ziche, M., L. Morbidelli, E. Masini, H. Granger, P. Geppetti and F. Ledda, 1993. Nitric oxide promotes DNA synthesis and cyclic GMP formation in endothelial cells from postcapillary venules. Biochem. Biophys. Res. Commun., 192: 1198-1203.
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  146. Pistelli, A., M.G. di Bello, S. Raspanti, E. Masini and P.F. Mannaioni, 1993. New pharmacological profiles of loratadine: Effects on platelet aggregation and histamine release from repository cells. Agents Actions, 38: C200-C202.
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  147. Masini, E., P. Bechi, R. Dei, T. Vardar, M.G. di Bello, S. Raspanti and P.F. Mannaioni, 1993. Helicobacter pylori potentiates histamine release from rat serosal mast cells. Agents Actions, 38: C197-C199.
    CrossRef  |  Direct Link  |  

  148. Mannaioni, P.P.F., M.G. di Bello, S. Raspanti, F. Gambassi, L. Mugnai and E. Masini, 1993. Histamine release by human platelets. Agents Actions, 38:: C203-C205.
    CrossRef  |  Direct Link  |  

  149. Gambassi, F., M. Lupini, M.G. di Bello, L. Mugnai, E. Masini and P.F. Mannaioni, 1993. Histamine release by free radicals: Effect of defibrotide (DFT) and its fraction Agents Action, 38: C206-C208.
    CrossRef  |  Direct Link  |  

  150. Bechi, P., R. Dei, M.G. Di Bello and E. Masini, 1993. Helicobacter pylori potentiates histamine release from serosal rat mast cells In vitro. Dig. Dis. Sci., 38: 944-949.
    CrossRef  |  PubMed  |  Direct Link  |  

  151. Bechi, P., A. Amorosi, R. Mazzanti, R. Dei, S. Bianchi, L. Mugnai and E. Masini, 1993. Reflux-related gastric mucosal injury is associated with increased mucosal histamine content in humans. Gastroenterology, 104: 1057-1063.
    PubMed  |  Direct Link  |  

  152. Masini, E., F. Gambassi, M. Lupini, A. Pistelli and P.F. Mannaioni, 1992. Correlation between nitric oxide synthesis and histamine release in mast cells from spontaneously hypertensive rats: Influence of aging. Int. Arch. Allergy Immunol., 99: 404-407.
    CrossRef  |  

  153. Masini, E., A. Pistelli, M.G. Di Bello, S. Raspanti and P.F. Mannaioni, 1992. Influence of aging on mast cells production of a nitric oxide-like factor: Comparison between normal and hypertensive rats. Agents Actions, 36: C268-C271.
    CrossRef  |  

  154. Mannaioni, P.F., M.G. Di Bello, S. Raspanti, F. Gambassi, L. Mugnai and E. Masini, 1992. Platelet histamine: Characterization of the proaggregatory effect of histamine in human platelets. Int. Arch. Allergy Immunol., 99: 394-396.
    CrossRef  |  

  155. Mannaioni, P.F., A. Pistelli, M.G. Di Bello, F. Gambassi and E. Masini, 1992. H1-receptors dependent increase in platelet aggregation is mediated by intracellular calcium. Agents Actions, 38: 401-405.
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  156. Lupini, M., F. Gambassi, L. Mugnai, S. Bianchi, E. Masini and P.F. Mannaioni, 1992. Defibrotide decreases histamine release in guinea-pig model of myocardial ischemia and reperfusion in vitro. Agents Actions, 38: 333-335.
    CrossRef  |  

  157. Gambassi, F., A. Pistelli, M.G. Di Bello, M. Lupini, P.F. Mannaioni and E. Masini, 1992. Ischemia-reperfusion injury and histamine release in isolated perfused guinea-pig heart: Effects of nitric oxide generators. Pharmacol. Res., 1: 11-12.

  158. Botti, P., A. Pistelli, F. Gambassi, A.M. Zorn and L. Caramelli et al., 1992. HBV and HCV infection in i.v. drug addicts: Coinfection with HIV. Arch. Virol. Supply, 4: 329-332.
    PubMed  |  

  159. Salvemini, D., E. Masini, A. Pistelli, P.F. Mannaioni and J.R. Vane, 1991. Nitric oxide: A regulatory mediator of mast cells reactivity. J. Cariovasc Pharmacol., 17: 258-264.
    CrossRef  |  

  160. Masini, E., S. Bianchi, L. Mugnai, F. Gambassi, M. Lupini, A. Pistelli and P.F. Mannaioni, 1991. The effect of nitric oxide generators on ischemia reperfusion injury and histamine release in isolated perfused guinea-pig heart. Agents Actions, 33: 53-56.
    PubMed  |  

  161. Masini, E., P.F. Mannaioni, A. Pistelli, D. Salvemini and J.R. Vane, 1991. Impairment of the L-arginine-nitric oxide pathway in mast cells from spontaneously hypertensive rats. Biochem. Biophys. Res. Commun., 177: 1178-1182.
    CrossRef  |  

  162. Masini, E., F. Gambassi, S. Bianchi, L. Mugnai, M. Lupini, A. Pistelli and P.F. Mannaioni, 1991. Effect of nitric oxide generators on ischemia-reperfusion injury and histamine release in isolated perfused guinea pig heart. Int. Arch. Allergy Applied Immunol., 94: 257-258.
    PubMed  |  

  163. Masini, E., D. Salvemini, A. Pistelli, P.F. Mannaioni and J.R. Vane, 1991. Rat mast cells synthesize a nitric oxide like-factor which modulates the release of histamine. Agents Actions, 33: 61-63.
    PubMed  |  

  164. Mannaioni, P.F., E. Masini, A. Pistelli, D. Salvemini and J.R. Vane, 1991. Mast cells as a source of superoxide anions and nitric oxide-like factor: Relevance to histamine release. Int. J. Tissue React., 13: 271-278.
    PubMed  |  

  165. Mannaioni, P.F., A. Pistelli, F. Gambassi, M.G. Di Bello, S. Raspanti and E. Masini, 1991. Definition of platelet-derived histamine-releasing factor and histaminergic receptors modulating platelet aggregation. Int. Arch. Allergy Applied Immunol., 94: 301-302.
    PubMed  |  

  166. Mannaioni, P.F., A. Pistelli, F. Gambassi, M.G. Di Bello, S. Raspanti and E. Masini, 1991. A place for free radicals in platelet-derived histamine releasing factor (PDHRF) and evidence that histaminergic receptors modulate platelet aggregation. Agents Actions, 33: 57-60.
    PubMed  |  

  167. Mannaioni, P.F., A. Pistelli, F. Gambassi, M.G. Di Bello, S. Rasoanti and E. Masini, 1991. Maste cells as paraneurons: The endogenous control of histaminerelease. J. Chemother, 3: 48-51.

  168. Salvemini, D., E. Masini, E. Anggard, P.F. Mannaioni and J. Vane, 1990. Synthesis of a nitric oxide-like factor from L-arginine by rat serosal mast cells: Stimulation of guanylate cyclase and inhibition of platelet aggregation. Biochem. Biophys. Res. Commun., 169: 596-601.
    CrossRef  |  

  169. Masini, E., S. Bianchi, F. Gambassi, B. Palmerani, A. Pistelli, L. Carlomagno and P.F. Mannaioni, 1990. Ischemia reperfusion injury and histamine release in isolated and perfused guinea-pig heart: Pharmacological interventions. Agents Actions, 30: 198-201.
    PubMed  |  

  170. Masini, E., B. Palmerani, F. Gambassi, A. Pistelli and E. Giannella et al., 1990. Histamine release from rat mast cells induced by metabolic activation of polyunsaturated fatty acids into free radicals. Biochem. Pharmacol., 39: 879-889.
    PubMed  |  

  171. Mannaioni, P.F., B. Palmerani, A. Pistelli, F. Gambassi, E. Giannella, T. Bani Sacchi and E. Masini, 1990. Histamine release by platelet aggregation. Agents Actions, 30: 44-48.
    PubMed  |  

  172. Rucci, L., E. Masini, R. Arbi Riccardi, E. Giannella and C. Fioretti et al., 1989. Vidian nerve resection, histamine turnover and mucosal mast cell function in patients with chronic hypertrophic non-allergic rhinitis. Agents Actions, 28: 224-230.
    PubMed  |  

  173. Pellegrini-Giampietro, D.E., F. Moroni, A. Pistelli, B. Palmerani and A.M. Zorn et al., 1989. Pyrrolidone carboxylic acid in acute and chronic alcoholism. Preclinical and clinical studies. Recenti Prog. Med., 80: 160-164.
    PubMed  |  

  174. Masini, E., F. Gambassi, E. Giannella, B. Palmerani, A. Pistelli, L. Carlomagno and P.F. Mannaioni, 1989. Ischemia-reperfusion injury and histamine release in isolated guinea-pig heart: The role of free radicals. Agents Actions, 27: 154-157.
    PubMed  |  

  175. Masini, E., E. Giannella, B. Palmerani, A. Pistelli, F. Gambassi and P.F. Mannaioni, 1989. Prostaglandin H synthetase activates xenobiotics into free radicals: Histamine release and biochemical characteristics. Int. Arch. Allergy Applied Immunol., 88: 134-135.
    PubMed  |  

  176. Masini, E., E. Giannella, B. Palmerani, A. Pistelli, F. Gambassi and P.F. Mannaioni, 1989. Free radicals induce ischemia-reperfusion injury and histamine release in the isolated guinea pig heart. Int. Arch. Allergy Applied Immunol., 88: 132-133.
    PubMed  |  

  177. Masini, E., E. Giannella, A. Pistelli, B. Palmerani, F. Gambassi, B. Occupati and P.F. Mannaioni, 1989. Histamine release by free radicals: The relationship with the signal transduction system. Agents Actions, 27: 72-74.
    CrossRef  |  

  178. Rucci, L., E. Masini, M.B. Cirri Borghi, E. Giannella and P.F. Mannaioni, 1988. Histamine release from nasal mucosal mast cells in patients with chronic hypertrophic non-allergic rhinitis, after parasympathetic nerve stimulation. Agents Actions, 25: 314-320.
    PubMed  |  

  179. Palmerani, B., A. Pistelli, F. Gambassi, E. Giannella, E. Masini and P.F. Mannaioni, 1988. Histamine release by free radicals during prostaglandin-H-synthetase dependent oxidation of xenobiotics. Pharmacol. Res. Commun., 20: 437-438.
    PubMed  |  

  180. Masini, E., E. Giannella, S. Bianchi, B. Palmerani, A. Pistelli and P.F. Mannaioni, 1988. Histamine release in acute coronary occlusion-reperfusion in isolated guinea-pig heart. Agents Actions, 23: 266-269.
    PubMed  |  

  181. Mannaioni, P.F., R. Fantozzi, E. Giannella and E. Masini, 1988. Pathophysiological significance of the distribution of histamine receptor sub-types: A proposed dual role for histamine in inflammation and type I hypersensitivity reactions. Agents Actions, 24: 26-34.
    CrossRef  |  

  182. Mannaioni, P.F., E. Giannella, B. Palmerani, A. Pistelli and F. Gambassi et al., 1988. Free radicals as endogenous histamine releasers. Agents Actions, 23: 129-142.
    PubMed  |  

  183. Mannaioni, P.F. and E. Masini, 1988. The release of histamine by free radicals. Free Radic Biol. Med., 5: 177-197.
    PubMed  |  

  184. Giannella, E., E. Masini, B. Palmerani, A. Pistelli and P.F. Mannaioni, 1988. Modulation of anaphylactic histamine release by calcium channel agonists and antagonists. Agents Actions, 23: 185-187.
    PubMed  |  

  185. Fantozzi, R., L. Caramelli, M. Barattini, P. Botti and F. Ledda et al., 1988. Clinical experiences with Ro 15-1788 (Anexate) in benzodiazepine and mixed-drug overdoses. Resuscitation, 16: 79-82.
    PubMed  |  

  186. Masini, E., E. Giannella, T. Bani-Sacchi, R. Fantozzi, B. Palmerani and P.F. Mannaioni, 1987. Histamine release from serosal mast cells by intermediate products of arachidonic acid metabolism. Agents Actions, 20: 202-225.
    PubMed  |  

  187. Masini, E., E. Giannella, S. Bianchi and P.F. Mannaioni, 1987. Histamine and lactate dehydrogenase (LDH) release in ischemic myocardium of the guinea-pig. Agents Actions, 20: 281-283.
    PubMed  |  

  188. Masini, E., B. Palmerani, T. Bani-Sacchi, E. Giannella, R. Fantozzi and P.F. Mannaioni, 1987. Mast cell histamine release induced by intermediate products of arachidonic acid metabolism. Int. Arch. Allergy Applied Immunol., 82: 279-282.
    PubMed  |  

  189. Fantozzi, R., L. Caramelli, F. Ledda, F. Moroni and E. Masini et al., 1987. Biological markers and therapeutic outcome in alcoholic disease: A twelve-year survey. Klin Wochenschr, 65: 27-33.
    PubMed  |  

  190. Blandina, P., S. Brunelleschi, R. Fantozzi, E. Giannella, P.F. Mannaioni and E. Masini, 1987. The antianaphylactic action of histamine H2-receptor agonists in the guinea-pig isolated heart. Br. J. Pharmacol., 90: 459-466.
    PubMed  |  

  191. Masini, E., M. Lodovici, R. Fantozzi, S. Brunelleschi, A. Conti and P.F. Mannaioni, 1986. Histamine release by free radicals: Paracetamol-induced histamine release from rat peritoneal mast cells after in vitro activation by monooxygenase. Agents Actions, 18: 85-88.
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  192. Masini, E., L. Rucci, M.B. Cirri-Borghi, E. Giannella and P.F. Mannaioni, 1986. Stimulation and resection of Vidian nerve in patients with chronic hypertrophic non-allergic rhinitis: Effect on histamine content in nasal mucosa. Agents Actions, 18: 251-253.
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  193. Masini, E., F. Franconi, V.A. Peduto, E. Pieraccioli, R. Matucci and G.P. Novelli, 1986. Liver function following hypovolemic hypotension in rats anaesthetized with halothane or enflurane. Pharmacol. Res. Commun., 18: 847-856.
    PubMed  |  

  194. Fantozzi, R., S. Brunelleschi, A. Rubino, S. Tarli, E. Masini and P.F. Mannaioni, 1986. FMLP-activated neutrophils evoke histamine release from mast cells. Agents Actions, 18: 155-158.
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  195. Fantozzi, R., F. Ledda, L. Caramelli, F. Moroni and P. Blandina et al., 1986. Clinical findings and follow-up evaluation of an outbreak of mushroom poisoning-survey of Amanita phalloides poisoning. Klin Wochenschr, 64: 38-43.
    PubMed  |  

  196. Bani-Sacchi, T., M. Barattini, S. Bianchi, P. Blandina and S. Brunelleschi et al., 1986. The release of histamine by parasympathetic stimulation in guinea-pig auricle and rat ileum. J. Physiol., 371: 29-43.
    PubMed  |  

  197. Rucci, L., M.B. Borghi Cirri, E. Masini and O. Fini Storchi, 1985. Vidian nerve resection in chronic hypertrophic non allergic rhinitis: Effects on histamine content, number and rate of degranulation processes of mast cells in nasal mucosa. Rhinology, 23: 309-314.
    PubMed  |  

  198. Masini, E., R. Fantozzi, P. Blandina, S. Brunelleschi and P.F. Mannaioni, 1985. The riddle of cholinergic histamine release from mast cells. Prog. Med. Chem., 22: 267-291.
    PubMed  |  

  199. Masini, E., R. Fantozzi, A. Conti, P. Blandina, S. Brunelleschi and P.F. Mannaioni, 1985. Mast cell heterogeneity in response to cholinergic stimulation. Int. Arch. Allergy Applied Immunol., 77: 184-185.
    PubMed  |  

  200. Masini, E., R. Fantozzi, A. Conti, P. Blandina, S. Brunelleschi and P.F. Mannaioni, 1985. Immunological modulation of cholinergic histamine release in isolated rat mast cells. Agents Actions, 16: 152-154.
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  201. Masini, E., J. Planchenault, F. Pezziardi, P. Gautier and J.P. Gagnol, 1985. Histamine-releasing properties of Polysorbate 80 in vitro and in vivo: Correlation with its hypotensive action in the dog. Agents Actions, 16: 470-477.
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  202. Masini, E., J. Phanchenault, F. Pezziardi, P. Gautier and J.P. Gagnol, 1985. Histamine release during an experimental coronary thrombosis in awake dog. Agents Actions, 16: 227-230.
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  203. Fantozzi, R., S. Brunelleschi, L. Giuliattini, P. Blandina, E. Masini, G. Cavallo and P.F. Mannaioni, 1985. Mast cell and neutrophil interactions: A role for superoxide anion and histamine. Agents Actions, 16: 260-264.
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  204. Fantozzi, R., S. Brunelleschi, S. Cambi, P. Blandina, E. Masini and P.F. Mannaioni, 1984. Autacoid andβ-adrenergic agonist modulation of N-formylmethionyl-leucyl-phenylalanine evoked lysosomal enzyme release from human neutrophils. Agents Actions, 14: 441-450.
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  205. Blandina, P., M. Barattini, R. Fantozzi, E. Masini, S. Brunelleschi and P.F. Mannaioni, 1984. Mediator release from isolated rat ileum in response to field stimulation. Agents Actions, 14: 405-459.
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  206. Peduto, V.A., E. Masini, M. Ludovici, E. Pieraccioli, P. Dolara and G.P. Novelli, 1983. Stimulation of drug-metabolizing enzymes by nitrous oxide in the rat. Acta Anaesthesiol Scand, 27: 439-442.
    PubMed  |  

  207. Ledda, F., P. Blandina, P. Botti, L. Caramelli and R. Fantozzi et al., 1983. Overall evaluation of treatment modalities for heroin addiction in a toxicology unit. Subst Alcohol. Actions Misuse, 4: 283-304.
    PubMed  |  

  208. Fantozzi, R., S. Brunelleschi, G.B. Soldaini, P. Blandina, E. Masini, L. Raimondi and P.F. Mannaioni, 1983. N-Formylmethionyl-leucyl-phenylalanine: Different releasing effects on human neutrophils and rat mast cells. Agents Actions, 13: 218-221.
    PubMed  |  

  209. Fantozzi, R., E. Masini, P. Blandina, S. Brunelleschi and P.F. Mannaioni, 1983. Receptor modulation of histamine release in isolated purified rat mast cells. Monogr Allergy, 18: 190-192.

  210. Masini, E., R. Fantozzi, P. Blandina, S. Brunelleschi and P.F. Mannaioni, 1982. Muscarinic cholinergic stimulation. Agents Actions, 13: 179-182.

  211. Masini, E., R. Fantozzi, P. Blandina, A. Galli and T. Bani-Sacchi et al., 1982. Presence of functionally active β-adrenoceptors in rat mast cells. Naunyn Schmiedebergs Arch. Pharmacol., 321: 171-176.
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  212. Masini, E., P. Blandina, S. Brunelleschi and P.F. Mannaioni, 1982. Evidence for H2-receptor-mediated inhibition of histamine release from isolated rat mast cells. Agents Actions, 12: 85-88.
    PubMed  |  

  213. Masini, E., P. Blandina and P.F. Mannaioni, 1982. Removal of alpha-amanitin from blood by hemoperfusion over uncoated charcoal. Experimental results. Contrib Nephrol., 29: 76-81.
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  214. Masini, E., P. Blandina and P.F. Mannaioni, 1982. Mast cell receptors controlling histamine release: Influences on the mode of action of drugs used in the treatment of adverse drug reactions. Klin. Wochenschr, 60: 1031-1038.
    PubMed  |  

  215. Masini, E., G. Luciani, P. Blandina, G. Fabrizi, A. Becucci, G. Minnini and P.F. Mannaioni, 1982. No evidence of opiate-like withdrawal by naloxone in subjects treated chronically with clonidine. Int. J. Clin. Pharm. Res., 2: 27-31.

  216. Masini, E., R. Fantozzi, P. Blandina, F. Ledda, F. Moroni and P. Mannaioni, 1981. Epidemiological survey of intoxications in Florence in the last ten years. Clin. Toxicol., 18: 1157-1162.
    PubMed  |  

  217. Masini, E., P. Blandina, R. Fantozzi, S. Brunelleschi and P.F. Mannaioni, 1981. Correlation between cholinergic histamine release and quinuclidinyl-benzilate ([3H]-QNB) binding in mast cell membranes. Agents Actions, 11: 55-59.
    PubMed  |  

  218. Masini, E., P. Blandina, P.F. Mannaioni and G. Luciani, 1981. Clonidine and naloxone for rapid opiate detoxication: Comparison between treatments. Clin. Toxicol., 18: 1021-1026.
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  219. Fantozzi, R., F. Martinelli, E. Masini, A. Sodi, L. Amaducci and P. Mannaioni, 1981. Use of haemoperfusion with uncoated charcoal in the management of acute intoxications with barbiturate and salicylate. Subst Alcohol. Actions Misuse, 2: 55-62.
    PubMed  |  

  220. Fantozzi, R., G. Luciani, E. Masini, P. Blandina and P. Mannaioni, 1980. Clonidine and naloxone-induced opiate withdrawal: A comparison between clonidine and morphine in man. Subst Alcohol. Actions Misuse, 1: 369-373.
    PubMed  |  

  221. Fantozzi, R., E. Masini, P. Blandina, T. Bani-Sacchi, L. Zilletti and P.F. Mannaioni, 1980. Inhibition of cholinergic histamine release in rat mast cells. Agents Actions, 10: 139-140.
    PubMed  |  

  222. Blandina, P., R. Fantozzi, P.F. Mannaioni and E. Masini, 1980. Characteristics of histamine release evoked by acetylcholine in isolated rat mast cells. J. Physiol., 301: 281-293.
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  223. Fantozzi, R., E. Masini, P. Blandina and P.F. Mannaioni, 1979. Cholinergic histamine release: Evidence of muscarinic receptors in rat mast cells. Agents Actions, 9: 57-58.
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  224. Fantozzi, R., F. Moroni, E. Masini, P. Blandina and P.F. Mannaioni, 1978. Modulation of the spontaneous histamine release by adrenergic and cholinergic drugs. Agents Actions, 8: 347-358.
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  225. Fantozzi, R., E. Masini, P. Blandina, P.F. Mannaioni and T. Bani-Sacchi, 1978. Release of histamine from rat mast cells by acetylcholine. Nature, 273: 473-474.
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  226. Moroni, F., R. Fantozzi, E. Masini and P.F. Mannaioni, 1977. The modulation of histamine release by alpha-adrenoceptors: Evidences in murine neoplastic mast cells. Agents Actions, 7: 57-61.
    PubMed  |  

  227. Moroni, F., R. Fantozzi, E. Masini and P.F. Mannaioni, 1977. The influence of catecholamines and serotonin on histamine uptake and metabolism by guinea pig atrium. Eur. J. Pharmacol., 41: 59-63.
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  228. Moroni, F., R. Fantozzi, E. Masini and P.F. Mannaioni, 1976. A trend in the therapy of Amanita phalloides poisoning. Arch. Toxicol., 36: 111-115.
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  229. Moroni, F., R. Fantozzi, E. Masini and P.F. Mannaioni, 1975. Studies on the 14C-histamine release induced by histamine in mouse neoplastic mast cells. Agents Actions, 5: 424-426.
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  230. Mannaioni, P.F., F. Moroni, R. Fantozzi and E. Masini, 1975. Studies on the 14C-histamine release induced by noradrenaline in mouse neoplastic mast cells. Agents Actions, 5: 417-423.
    PubMed  |  

  231. Fantozzi, R., F. Franconi, P.F. Mannaioni, E. Masini and F. Moroni, 1975. Interaction of histamine H1-and H2-receptor antagonists with histamine uptake and metabolism by guinea-pig isolated atrium and mouse neoplastic mast cells cells in vitro. Br. J. Pharmacol., 53: 569-574.
    PubMed  |