Dr. Maurizio  Bifulco

Dr. Maurizio Bifulco

Professor
Universita degli Studi di Salerno, Italy


Highest Degree
M.D. in Medicine from Universita degli Studi di Napoli Federico II, Italy

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Area of Interest:

Biomedical Sciences
100%
Plasmatic Protein Effects
62%
Thyreotropin Hormone
90%
Cholesterol Metabolism
75%
Cellular Morphology
55%

Education

1980

M.D.

Universita degli Studi di Napoli Federico II, Italy

Medicine

Selected Publications

  1. Pisanti, S., P. Picardi, A. D'Alessandro, C. Laezza and M. Bifulco, 2013. The endocannabinoid signaling system in cancer. Trends Pharmacol. Sci., 34: 273-282.
    CrossRef  |  

  2. Malfitano, A.M., C. Laezza, G. Saccomanni, T. Tuccinardi and C. Manera et al., 2013. Immune-modulation and properties of absorption and blood brain barrier permeability of 1, 8-naphthyridine derivatives. J. Neuroimmune Pharmacol., 8: 1077-1086.
    CrossRef  |  

  3. Malfitano, A.M., C. Laezza, A. D'Alessandro, C. Procaccini and G. Saccomanni et al., 2013. Effects on immune cells of a new 1, 8-naphthyridin-2-one derivative and its analogues as selective CB2 agonists: Implications in multiple sclerosis. PloS One, Vol. 8. 10.1371/journal.pone.0062511.
    CrossRef  |  

  4. Laezza, C., A. d'Alessandro, A.M. Malfitano and M. Bifulco, 2013. Anandamide inhibits the Wnt/β-catenin signalling pathway in human breast cancer MDA MB 231 cells. Eur. J. Cancer, 49: 2066-2067.
    CrossRef  |  PubMed  |  

  5. Guerra, A., P. Zeppa, M. Bifulco and M. Vitale, 2013. Concomitant BRAFV600E mutation and RET/PTC rearrangement is a frequent occurrence in papillary thyroid carcinoma. Thyroid, (In Press). .
    PubMed  |  Direct Link  |  

  6. Gazzerro, P., E. Ciaglia and M. Bifulco, 2013. Statins and cancer‐related mortality: An open question. Basic Clinical Pharmacol. Toxicol., 113: 73-74.
    CrossRef  |  

  7. Gazzerro P. and M. Bifulco, 2013. Statins and cancer in gastroenterology: New insight? Gastroenterology, 144: 1572-1573.
    CrossRef  |  

  8. Gangemi, G., P. Gazzerro, D. Fiore, M.C. Proto and S. Butini et al., 2013. PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines. Eur. J. Pharmacol., 714: 379-387.
    CrossRef  |  PubMed  |  

  9. Ciaglia, E., S. Pisanti, P. Picardi, C. Laezza and A.M. Malfitano et al., 2013. N6-isopentenyladenosine, an endogenous isoprenoid end product, directly affects cytotoxic and regulatory functions of human NK cells through FDPS modulation. J. Leukoc Biol., 94: 1207-1219.
    CrossRef  |  

  10. Bifulco, M., A. D'Alessandro, S. Paladino, A.M. Malfitano, M. Notarnicola, M.G. Caruso and C. Laezza, 2013. N6‐isopentenyladenosine improves nuclear shape in fibroblasts from humans with progeroid syndromes by inhibiting the farnesylation of prelamin A. FEBS J., 280: 6223-6232.
    CrossRef  |  

  11. Bifulco, M., 2013. Risk of diabetes with statins must be monitored in each patient. BMJ., Vol. 347. (In Press). 10.1136/bmj.f4170.
    CrossRef  |  

  12. Bifulco, M. and S. Pisanti, 2013. Adiponcosis: A new term to name the obesity and cancer link. J. Clinical Endocrinol. Metabolism, 98: 4664-4665.
    Direct Link  |  

  13. Bifulco M. and P. Gazzerro, 2013. The critic network among scientists, the right to care and the expectations of our society: The case of a controversial stem-cell therapy in Italy. EMBO Rep., 14: 578-578.

  14. Salzano, M., M.R. Rusciano, E. Russo, M. Bifulco, L. Postiglione and M. Vitale, 2012. Calcium/calmodulin-dependent protein kinase II (CaMKII) phosphorylates Raf-1 at serine 338 and mediates Ras-stimulated Raf-1 activation. Cell Cycle, 11: 2100-2106.
    Direct Link  |  

  15. Proto, M.C., P. Gazzerro, L. Di Croce, A. Santoro and A.M. Malfitano et al., 2012. Interaction of endocannabinoid system and steroid hormones in the control of colon cancer cell growth. J. Cell. Physiol., 227: 250-258.
    CrossRef  |  

  16. Manera, C., G. Saccomanni, A.M. Malfitano, S. Bertini and F. Castelli et al., 2012. Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: An investigation of the 1, 8-naphthyridin-2 (1 H)-one scaffold. Eur. J. Med. Chem., 52: 284-294.
    CrossRef  |  

  17. Malfitano, A.M., C. Laezza, M. Galgani, G. Matarese, A. D'Alessandro, P. Gazzerro and M. Bifulco, 2012. The CB1 receptor antagonist rimonabant controls cell viability and ascitic tumour growth in mice. Pharmacol. Res., 65: 365-371.
    CrossRef  |  

  18. Laezza, C., A. D'Alessandro, S. Paladino, A. Maria Malfitano and M. Chiara Proto et al., 2012. Anandamide inhibits the Wnt/β-catenin signalling pathway in human breast cancer MDA MB 231 cells. Eur. J. Cancer, 48: 3112-3122.
    CrossRef  |  

  19. Gazzerro, P., M.C. Proto, G. Gangemi, A.M. Malfitano and E. Ciaglia et al., 2012. Pharmacological actions of statins: A critical appraisal in the management of cancer. Pharmacol. Rev., 64: 102-146.
    CrossRef  |  

  20. Caruso, M.G., P. Gazzerro, M. Notarnicola, A.M. Cisternino and V. Guerra et al., 2012. Cannabinoid type 1 receptor gene polymorphism and macronutrient intake. J. Nutrigenet. Nutrigenomics, 5: 305-313.
    CrossRef  |  PubMed  |  

  21. Prota, L., A. Santoro, M. Bifulco, R.P. Aquino, T. Mencherini and P. Russo, 2011. Leucine enhances aerosol performance of Naringin dry powder and its activity on cystic fibrosis airway epithelial cells. Int. J. Pharmaceutics, 412: 8-19.
    CrossRef  |  

  22. Pisanti, S., P. Picardi, L. Prota, M.C. Proto and C. Laezza et al., 2011. Genetic and pharmacologic inactivation of cannabinoid CB1 receptor inhibits angiogenesis. Blood, 117: 5541-5550.
    CrossRef  |  

  23. Notarnicola, M., S. Pisanti, V. Tutino, D. Bocale and M.T. Rotelli et al., 2011. Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cells. Genes Nutr., 6: 63-69.
    CrossRef  |  

  24. Malfitano, A.M., S. Sosa, C. Laezza, M. De Bortoli, A. Tubaro and M. Bifulco, 2011. Rimonabant reduces keratinocyte viability by induction of apoptosis and exerts topical anti‐inflammatory activity in mice. Br. J. Pharmacol., 162: 84-93.
    CrossRef  |  

  25. Malfitano, A.M., E. Ciaglia, G. Gangemi, P. Gazzerro, C. Laezza and M. Bifulco, 2011. Update on the endocannabinoid system as an anticancer target. Expert Opin. Ther. Targets, 15: 297-308.
    CrossRef  |  

  26. Donadelli, M., I. Dando, T. Zaniboni, C. Costanzo and E. Dalla Pozza et al., 2011. Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism. Cell Death Dis., Vol. 2. 10.1038/cddis.2011.36.
    CrossRef  |  

  27. Scrima, M., S. Di Marino, M. Grimaldi, A. Mastrogiacomo, E. Novellino, M. Bifulco and A.M. D'Ursi, 2010. Binding of the hemopressin peptide to the cannabinoid CB1 receptor: Structural insights. Biochemistry, 49: 10449-10457.
    CrossRef  |  

  28. Monteleone, P., M. Bifulco, G. Maina, A. Tortorella and P. Gazzerro et al., 2010. Investigation of CNR1 and FAAH endocannabinoid gene polymorphisms in bipolar disorder and major depression. Pharmacol. Res., 61: 400-404.
    CrossRef  |  

  29. Linsalata, M., M. Notarnicola, V. Tutino, M. Bifulco and A. Santoro et al., 2010. Effects of anandamide on polyamine levels and cell growth in human colon cancer cells. Anticancer Res., 30: 2583-2589.
    Direct Link  |  

  30. Laezza, C., A.M. Malfitano, T. Di Matola, P. Ricchi and M. Bifulco, 2010. Involvement of Akt/NF‐κB pathway in N6‐isopentenyladenosine‐induced apoptosis in human breast cancer cells. Mol. Carcinog., 49: 892-901.
    CrossRef  |  

  31. Laezza, C., A.M. Malfitano, M.C. Proto, I. Esposito and P. Gazzerro et al., 2010. Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and of Ras farnesylation mediate antitumor effects of anandamide in human breast cancer cells. Endocr. Related Cancer, 17: 495-503.
    CrossRef  |  

  32. Gazzerro, P., A.M. Malfitano, M.C. Proto, A. Santoro and S. Pisanti et al., 2010. Synergistic inhibition of human colon cancer cell growth by the cannabinoid CB1 receptor antagonist rimonabant and oxaliplatin. Oncol. Rep., 23: 171-175.
    CrossRef  |  

  33. Gallotta, D., P. Nigro, R. Cotugno, P. Gazzerro, M. Bifulco and M.A. Belisario, 2010. Rimonabant-induced apoptosis in leukemia cell lines: Activation of caspase-dependent and-independent pathways. Biochem. Pharmacol., 80: 370-380.
    CrossRef  |  

  34. Cozzolino, R., G. Cali, M. Bifulco and P. Laccetti, 2010. A metabolically stable analogue of anandamide, Met-F-AEA, inhibits human thyroid carcinoma cell lines by activation of apoptosis. Invest. New Drugs, 28: 115-123.
    CrossRef  |  

  35. Aquila, S., C. Guido, A. Santoro, P. Gazzerro and C. Laezza et al., 2010. Rimonabant (SR141716) induces metabolism and acquisition of fertilizing ability in human sperm. Br. J. Pharmacol., 159: 831-841.
    CrossRef  |  

  36. Aquila, S., C. Guido, A. Santoro, I. Perrotta, C. Laezza, M. Bifulco and A. Sebastiano, 2010. Human sperm anatomy: Ultrastructural localization of the cannabinoid1 receptor and a potential role of anandamide in sperm survival and acrosome reaction. Anat. Rec., 293: 298-309.
    CrossRef  |  

  37. Vitale, M. and M. Bifulco, 2009. Thyroid cellular models: A warning concerning their application. Thyroid, 19: 1021-1022.
    CrossRef  |  

  38. Santoro, A., S. Pisanti, C. Grimaldi, A.A. Izzo and F. Borrelli et al., 2009. Rimonabant inhibits human colon cancer cell growth and reduces the formation of precancerous lesions in the mouse colon. Int. J. Cancer, 125: 996-1003.
    CrossRef  |  

  39. Pisanti, S., A.M. Malfitano, C. Grimaldi, A. Santoro, P. Gazzerro, C. Laezza and M. Bifulco, 2009. Use of cannabinoid receptor agonists in cancer therapy as palliative and curative agents. Best Pract. Res. Clin. Endocrinol. Metab., 23: 117-131.
    CrossRef  |  

  40. Pisanti, S. and M. Bifulco, 2009. Endocannabinoid system modulation in cancer biology and therapy. Pharmacol. Res., 60: 107-116.
    CrossRef  |  

  41. Monteleone, P., M. Bifulco, C. Di Filippo, P. Gazzerro and B. Canestrelli et al., 2009. Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: Evidence for synergistic effects. Genes Brain Behav., 8: 728-732.
    CrossRef  |  

  42. Laezza, C., M.G. Caruso, T. Gentile, M. Notarnicola and A.M. Malfitano et al., 2009. N6-isopentenyladenosine inhibits cell proliferation and induces apoptosis in a human colon cancer cell line DLD1. Int. J. Cancer, 124: 1322-1329.
    CrossRef  |  PubMed  |  Direct Link  |  

  43. Bifulco, M., A. Santoro, C. Laezza and A.M. Malfitano, 2009. Cannabinoid receptor CB1 antagonists: State of the art and challenges. Vitamins Hormones, 81: 159-189.
    CrossRef  |  

  44. Bifulco, M., 2009. The endocannabinoid system: From biology to therapy. Pharmacol. Res., 60: 75-76.

  45. Bifulco, M. and S. Pisanti, 2009. End of the line for cannabinoid receptor 1 as an anti-obesity target? An opinion. Nat. Rev. Drug Discovery, Vol. 8. 10.1038/nrd2775-c1.
    CrossRef  |  

  46. Bifulco, M. and A. Santoro, 2009. Comment on When in Rome, reform. EMBO Rep., Vol. 10. 10.1038/embor.2009.38.
    CrossRef  |  

  47. Benavides, A., A. Napolitano, C. Bassarello, V. Carbone and P. Gazzerro et al., 2009. Oxylipins from Dracontium loretense. J. Nat. Prod., 72: 813-817.
    CrossRef  |  

  48. Aquila, S., C. Guido, C. Laezza, A. Santoro and V. Pezzi et al., 2009. A new role of anandamide in human sperm: Focus on metabolism. J. Cell. Physiol., 221: 147-153.
    CrossRef  |  

  49. Santoro, A., P. Gazzerro, A.M. Malfitano, S. Pisanti, C. Laezza and M. Bifulco, 2008. Reply to the letter to the editor Long-term cannabinoid receptor (CB1) blockade in obesity: Implications for the development of colorectal cancer. Int. J. Cancer, 123: 243-244.
    CrossRef  |  PubMed  |  Direct Link  |  

  50. Santoro, A., G. Bianco, P. Picerno, R.P. Aquino and G. Autore et al., 2008. Verminoside- and verbascoside-induced genotoxicity on human lymphocytes: Involvement of PARP-1 and p53 proteins. Toxicol. Lett., 178: 71-76.
    CrossRef  |  PubMed  |  Direct Link  |  

  51. Notarnicola, M., C. Messa, A. Orlando, M. Bifulco, C. Laezza, P. Gazzerro and M.G. Caruso, 2008. Estrogenic induction of cannabinoid CB1 receptor in human colon cancer cell lines. Scand. J. Gastroenterol., 43: 66-72.
    PubMed  |  

  52. Marra, M., A. Lombardi, E. Agostinelli, G. Giuberti and S. Zappavigna et al., 2008. Bovine serum amine oxidase and spm potentiate docetaxel and interferon-alpha effects in inducing apoptosis on human cancer cells through the generation of oxidative stress. Biochim. Biophys. Acta Mol. Cell Res., 1783: 2269-2278.
    CrossRef  |  PubMed  |  Direct Link  |  

  53. Malfitano, A.M., M.C. Proto and M. Bifulco, 2008. Cannabinoids in the management of spasticity associated with multiple sclerosis. Neuropsychiatr Dis. Treat, 4: 847-853.
    PubMed  |  

  54. Malfitano, A.M., C. Laezza, S. Pisanti, P. Gazzerro and M. Bifulco, 2008. Rimonabant (SR141716) exerts anti-proliferative and immunomodulatory effects in human peripheral blood mononuclear cells. Br. J. Pharmacol., 153: 1003-1010.
    CrossRef  |  PubMed  |  Direct Link  |  

  55. Laezza, C., S. Pisanti, A.M. Malfitano and M. Bifulco, 2008. The anandamide analog, Met-F-AEA, controls human breast cancer cell migration via the RHOA/RHO kinase signaling pathway. Endocr. Related Cancer, 15: 965-974.
    CrossRef  |  PubMed  |  

  56. Laezza, C., L. Fiorentino, S. Pisanti, P. Gazzerro and M. Caraglia et al., 2008. Lovastatin induces apoptosis of k-ras-transformed thyroid cells via inhibition of ras farnesylation and by modulating redox state. J. Mol. Med., 86: 1341-1351.
    CrossRef  |  PubMed  |  Direct Link  |  

  57. Esposito, I., M.C. Proto, P. Gazzerro, C. Laezza and C. Miele et al., 2008. The cannabinoid CB1 receptor antagonist Rimonabant stimulates 2-deoxyglucose uptake in skeletal muscle cells by regulating phosphatidylinositol-3-kinase activity. Mol. Pharmacol., 74: 1678-1686.
    Direct Link  |  

  58. Esposito, C., M. Scrima, A. Carotenuto, A. Tedeschi and P. Rovero et al., 2008. Structures and micelle locations of the nonlipidated and lipidated C-terminal membrane anchor of 2',3'-cyclic nucleotide-3'-phosphodiesterase. Biochemistry, 47: 308-319.
    CrossRef  |  PubMed  |  Direct Link  |  

  59. Cavallo, P., M.C. Proto, C. Patruno, A.D. Sorbo and M. Bifulco, 2008. The first cosmetic treatise of history. A female pointof view. Int. J. Cosmet. Sci., 30: 79-86.
    Direct Link  |  

  60. Bifulco, M., M. Marasco and S. Pisanti, 2008. Dietary recommendations in the medieval medical school of salerno: A lesson from the past. Am. J. Pharm. Med., 35: 602-603.

  61. Bifulco, M., A.M. Malfitano, S. Pisanti, C. Laezza, 2008. Endocannabinoids in endocrine and related tumours. Endocr. Related Cancer, 15: 391-408.
    CrossRef  |  PubMed  |  

  62. Bifulco, M., A.M. Malfitano, M.C. Proto, A. Santoro, M.G. Caruso and C. Laezza, 2008. Biological and pharmacological roles of N6-Isopentenyladenosine: An emerging anticancer drug. Anticancer Agents Med. Chem., 8: 200-204.
    CrossRef  |  PubMed  |  

  63. Bifulco, M., A.M. Malfitano and G. Marasco, 2008. Potential therapeutic role of statins in neurological disorders. Expert Rev. Neurother., 8: 827-837.
    CrossRef  |  PubMed  |  

  64. Bifulco, M., 2008. Therapeutic potential of statins in thyroid proliferative disease. Nat. Clin. Pract. Endocrinol. Metab., 4: 242-243.
    CrossRef  |  PubMed  |  Direct Link  |  

  65. Bifulco, M., 2008. In memory of nino salvatore: Tenth anniversary. Thyroid, 18: 91-92.

  66. Stingo, S., M. Masullo, E. Polverini, C. Laezza and I. Ruggiero et al., 2007. The N-Terminal domain of 2',3'-cyclic nucleotide 3'-phosphodiesterase harbors a GTP/ATP binding site. Chem. Biol. Drug Des., 70: 502-510.
    CrossRef  |  PubMed  |  Direct Link  |  

  67. Notarnicola, M., D.F. Altomare, M. Calvani, A. Orlando, M. Bifulco, B. D'Attoma and M.G. Caruso, 2007. Fatty acid synthase hyperactivation in human colorectal cancer: Relationship with tumor side and sex. Oncology, 71: 327-332.
    PubMed  |  

  68. Minutolo, F., M.G. Cascio, I. Carboni, T. Bisogno and G. Prota et al., 2007. Metabolically labile cannabinoid esters: A soft drug approach for the development of cannabinoid-based therapeutic drugs. Bioorg. Med. Chem. Lett., 17: 4878-4881.
    CrossRef  |  PubMed  |  Direct Link  |  

  69. Malfitano, A.M., G.A. Toruner, P. Gazzerro, C. Laezza and S. Husain et al., 2007. Arvanil and anandamide up-regulate CD36 expression in human peripheral blood mononuclear cells. Immunol. Lett., 109: 145-154.
    CrossRef  |  PubMed  |  Direct Link  |  

  70. Libertini, S., I. Iacuzzo, A, Ferraro, M. Vitale, M. Bifulco, A. Fusco and G. Portella, 2007. Lovastatin enhances the replication of the oncolytic adenovirus dl1520 and its antineoplastic activity against anaplastic thyroid carcinoma cells. Endocrinology, 148: 5186-5194.
    PubMed  |  

  71. Grimaldi, C. and M. Bifulco, 2007. Anandamide, an endogenous ligand of cannabinoid receptors, inhibits human breast cancer cell proliferation through a lipid rafts mediated mechanism. Pharmacologyonline, 1: 1-45.

  72. Gazzerro, P., M.G. Caruso, M. Notarnicola, G. Misciagna, V. Guerra, C. Laezza and M. Bifulco, 2007. Association between cannabinoid type-1 receptor polymorphism and body mass index in a Southern Italian population. Int. J. Obes., 31: 908-912.
    CrossRef  |  PubMed  |  Direct Link  |  

  73. Bifulco, M., P. Gazzerro, C. Laezza and F. Pentimalli, 2007. Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (review). Oncol. Rep., 17: 813-816.
    PubMed  |  

  74. Bifulco, M., C. Laezza and A.M. Malfitano, 2007. From anecdotal evidence of cannabinoids in multiple sclerosis to emerging new therapeutical approaches. Mult. Scler., 13: 133-134.
    CrossRef  |  Direct Link  |  

  75. Bifulco, M., C. Grimaldi, P. Gazzerro, S. Pisanti and A. Santoro, 2007. Rimonabant: Just an antiobesity drug? Current evidence on its pleiotropic effects. Mol. Pharmacol., 71: 1445-1456.
    PubMed  |  

  76. Bifulco, M., 2007. Possible relationship between statin use and decreased prevalence, number and volume of thyroid nodules: A new indication for these drugs? Thyroid, 17: 903-903.
    CrossRef  |  PubMed  |  Direct Link  |  

  77. Bifulco, M., 2007. Brains made in Italy: Locked or unlocked? PLOS Med. .
    Direct Link  |  

  78. Bifulco, M. and P. Cavallo, 2007. Thyroidology in the medieval medical school of salerno. Thyroid, 17: 39-40.
    CrossRef  |  Direct Link  |  

  79. Bifulco, M. and M.G. Caruso, 2007. From the gastronomic revolution to the new globesity epidemic. J. Am. Diet Assoc., 107: 2058-2560.
    CrossRef  |  PubMed  |  Direct Link  |  

  80. Sarnataro, D., S. Pisanti, A. Santoro, P. Gazzerro, A.M. Malfitano, C. Laezza and M. Bifulco, 2006. The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits human breast cancer cell proliferation through a lipid raft-mediated mechanism. Mol. Pharmacol., 70: 1298-1306.
    PubMed  |  

  81. Pisanti, S., C. Borselli, P. Gazzerro, C. Laezza and M. Bifulco, 2006. Antiangiogenic activity of the endocannabinoid anandamide: Correlation to its tumor-suppressor efficacy. J. Cell. Physiol., 211: 495-503.
    CrossRef  |  PubMed  |  Direct Link  |  

  82. Malfitano, A.M., R. Cahill, P. Mitchell, G. Frankel and G. Dougan et al., 2006. Helicobacter pylori has stimulatory effects on naive T cells. Helicobacter, 11: 21-30.
    CrossRef  |  PubMed  |  Direct Link  |  

  83. Malfitano, A.M., G. Matarese, S. Pisanti, C. Grimaldi and C. Laezza et al., 2006. Arvanil inhibits T lymphocyte activation and ameliorates the course and progression of autoimmune encephalomyelitis. J. Neuroimmunol., 171: 110-119.
    CrossRef  |  

  84. Laezza, C., S. Pisanti, E. Crescenzi and M. Bifulco, 2006. Anandamide inhibits Cdk2 and activates Chk1 leading to cell cycle arrest in human breast cancer cells. FEBS Lett., 580: 6076-6082.
    CrossRef  |  PubMed  |  Direct Link  |  

  85. Laezza, C., M. Notarnicola, M.G. Caruso, C. Messa and M. Macchia et al., 2006. N6-isopentenyladenosine arrests tumor cell proliferation by inhibiting farnesyl diphosphate synthase and protein prenylation. FASEB J., 20: 412-418.
    PubMed  |  

  86. Laezza, C., G. Mazziotti, L. Fiorentino, P. Gazzerro and G. Portella et al., 2006. HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway. J. Mol. Med., 84: 967-973.
    CrossRef  |  PubMed  |  Direct Link  |  

  87. Grimaldi, C., S. Pisanti, C. Laezza, A.M. Malfitano and A. Santoro et al., 2006. Anandamide inhibits adhesion and migration of breast cancer cells. Exp. Cell Res., 312: 363-373.
    CrossRef  |  PubMed  |  Direct Link  |  

  88. Bifulco, M., C. Laezza, S. Pisanti and P. Gazzerro, 2006. Cannabinoids and cancer: Pros and cons of an antitumour strategy. Br. J. Pharmacol., 148: 123-135.
    CrossRef  |  PubMed  |  Direct Link  |  

  89. Sarnataro, D., C. Grimaldi, S. Pisanti, P. Gazzerro, C. Laezza, C. Zurzolo and M. Bifulco, 2005. Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells. FEBS Lett., 579: 6343-6349.
    CrossRef  |  PubMed  |  Direct Link  |  

  90. Messa, C., M. Notarnicola, F. Russo, A. Cavallini and V. Pallottini et al., 2005. Estrogenic regulation of cholesterol biosynthesis and cell growth in DLD-1 human colon cancer cells. Scand. J. Gastroenterol., 40: 1454-1461.
    CrossRef  |  PubMed  |  Direct Link  |  

  91. Malfitano, A.M., G. Matarese and M. Bifulco, 2005. From cannabis to endocannabinoids in multiple sclerosis: A paradigm of central nervous system autoimmune diseases. Curr. Drug Targets, 4: 667-675.
    PubMed  |  

  92. Eletto, D., A. Leone, M. Bifulco and M.F. Tecce, 2005. Effect of unsaturated fat intake from mediterranean diet on rat liver mRNA expression profile: Selective modulation of genes involved in lipid metabolism. Nutr. Metab. Cardiovasc. Dis., 15: 13-23.
    CrossRef  |  PubMed  |  Direct Link  |  

  93. Bifulco, M., 2005. Role of the isoprenoid pathway in ras transforming activity, cytoskeleton organization, cell proliferation and apoptosis. Life Sci., 77: 1740-1749.
    CrossRef  |  PubMed  |  Direct Link  |  

  94. Notarnicola, M., C. Messa, A. Cavallini, M. Bifulco and M.F. Tecce et al., 2004. Higher farnesyl diphosphate synthase activity in human colorectal cancer inhibition of cellular apoptosis. Oncology, 67: 351-358.
    PubMed  |  

  95. Di Marzo, V., M. Bifulco and L. De Petrocellis, 2004. The endocannabinoid system and its therapeutic exploitation. Nat. Rev. Drug Discovery, 3: 771-784.
    CrossRef  |  Direct Link  |  

  96. De Lago, E., A. Ligresti, G. Ortar, E. Morera and A. Cabranes et al., 2004. In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake. Eur. J. Pharmacol., 484: 249-257.
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  97. Corea, G., M. Iorizzi, V. Lanzotti, M. Cammareri, C. Conicella, C. Laezza and M. Bifulco, 2004. Astersedifolioside A-C, three new oleane-type saponins with antiproliferative activity. Bioorg. Med. Chem., 12: 4909-4915.
    CrossRef  |  PubMed  |  Direct Link  |  

  98. Bifulco, M., C. Laezza, M. Valenti, A. Ligresti, G. Portella and V. Di Marzo, 2004. A new strategy to block tumor growth by inhibiting endocannabinoid inactivation. FASEB J., 18: 1606-1608.
    PubMed  |  

  99. Portella, G., C. Laezza, P. Laccetti, L. De Petrocellis, V. Di Marzo and M. Bifulco, 2003. Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: Actions on signals involved in angiogenesis and metastasis. FASEB J., 17: 1771-1773.
    PubMed  |  

  100. Ligresti, A., T. Bisogno, I. Matias, L. De Petrocellis and M.G. Cascio et al., 2003. Possible endocannabinoid control of colorectal cancer growth. Gastroenterology, 125: 677-687.
    CrossRef  |  PubMed  |  Direct Link  |  

  101. Harrison, S., L. De Petrocellis, M. Trevisani, F. Benvenuti, M. Bifulco, P. Geppetti and V. Di Marzo, 2003. Capsaicin-like effects of N-arachidonoyl-dopamine in the isolated guinea pig bronchi and urinary bladder. Eur. J. Pharmacol., 475: 107-114.
    CrossRef  |  PubMed  |  Direct Link  |  

  102. Caruso, M.G., M. Notarnicola, M. Bifulco, C. Laezza and V. Guerra et al., 2003. Increased farnesyltransferase activity in human colorectal cancer: Relationship with clinicopathological features and K-ras mutation. Scand. J. Gastroenterol., 38: 80-85.
    PubMed  |  

  103. Mondola, P., R. Seru, M. Santillo, S. Damiano and M. Bifulco et al., 2002. Effect of Cu,Zn superoxide dismutase on cholesterol metabolism in human hepatocarcinoma (HepG2) cells. Biochem. Biophys. Res. Commun., 295: 603-609.
    PubMed  |  

  104. De Petrocellis, L., T. Bisogno, A. Ligresti, M. Bifulco, D. Melck and V. Di Marzo, 2002. Effect on cancer cell proliferation of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systems. Fundam. Clin. Pharmacol., 16: 297-302.
    CrossRef  |  PubMed  |  Direct Link  |  

  105. Cuda, G., R. Paterno, R. Ceravolo, M. Candidiota and N. Perrotti et al., 2002. Protection of human endothelial cells from oxidative stress: Role of Ras-ERK1/2 signalling. Circulation, 105: 968-974.
    PubMed  |  

  106. Brooks, J.W., G. Pryce, T. Bisogno, S.I. Jaggar and D.J.R. Hankey et al., 2002. Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB1/CB2 receptors. Eur. J. Pharmacol., 439: 83-92.
    CrossRef  |  Direct Link  |  

  107. Bifulco, M., C. Laezza, S. Stingo and J. Wolff, 2002. 2',3'-Cyclic nucleotide 3'-phosphodiesterase: A membrane-bound, microtubule-associated protein and membrane anchor for tubulin. Proc. Natl. Acad. Sci., 99: 1807-1812.
    PubMed  |  

  108. Bifulco, M. and V. Di Marzo, 2002. Targeting the endocannabinoid system in cancer therapy: A call for further research. Nat. Med., 8: 547-550.
    CrossRef  |  PubMed  |  Direct Link  |  

  109. Di Matola, T., F. D'Ascoli, C. Luongo, M. Bifulco, G. Rossi, G. Fenzi and M. Vitale, 2001. Lovastatin-induced apoptosis in thyroid cells: involvement of cytochrome c and lamin B. Eur. J. Endocrinol., 145: 645-650.
    PubMed  |  

  110. Di Marzo, V., D. Melck, P. Orlando, T. Bisogno and O. Zagoory et al., 2001. Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells. Biochem. J., 358: 249-255.
    PubMed  |  

  111. Bifulco, M., C. Laezza, G. Portella, M. Vitale, P. Orlando, L. De Petrocellis and V. Di Marzo, 2001. Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth. FASEB J., 15: 2745-2747.
    PubMed  |  

  112. Mondola, P., M. Bifulco, R. Seru, T. Annella, M.C. Ciriolo and M. Santillo, 2000. Presence of CuZn Superoxide Dismutase in human serum lipoproteins. FEBS Lett., 467: 57-60.
    CrossRef  |  PubMed  |  Direct Link  |  

  113. Melck, D., L. De Petrocellis, P. Orlando, T. Bisogno, C. Laezza, M. Bifulco and V. Di Marzo, 2000. Suppression of trk and prolactin receptor levels by endocannabinnoids leads to inhibition of human breast and prostate cancer cell proliferation. Endocrinology, 141: 118-126.

  114. Di Matola, T., F. Muller, G. Fenzi, G. Rossi, M. Bifulco, L.A. Marzano and M. Vitale, 2000. Serum withdrawal-induced apoptosis in thyroid cells is caused by loss of fibronectin-integrin interaction. J. Clin. Endocrinol. Metab., 85: 1188-1193.
    PubMed  |  

  115. Di Marzo, V., M. Bifulco and L. De Petrocellis, 2000. Endocannabinoids and multiple sclerosis: A blessing from the inner bliss? Trends Pharmacol. Sci., 21: 195-197.
    CrossRef  |  PubMed  |  Direct Link  |  

  116. Vitale, M., T. Di Matola, M. Bifulco, A. Casamassima, G. Fenzi and G. Rossi, 1999. Apoptosis induced by denied adhesion to extracellular matrix (anoikis) in thyroid epithelial cells is p53 dependent but fails to correlate with modulation of p53 expression. FEBS Lett., 462: 57-60.
    CrossRef  |  PubMed  |  Direct Link  |  

  117. Vitale, M., T. Di Matola, G. Rossi, C. Laezza, G. Fenzi and M. Bifulco, 1999. Prenyltransferase-inhibitors induce apoptosis in proliferating thyroid cells through a p53- independent, CRMA-sensitive and caspase-3-like protease dependent mechanism. Endocrinology, 140: 698-704.

  118. Santillo, M., A. Migliaro, P. Mondola, C. Laezza and S. Damiano et al., 1999. Dietary and hypothyroid hypercholesterolemia induces hepatic apolipoprotein E expression in the rat: Direct role of cholesterol. FEBS Lett., 463: 83-86.
    CrossRef  |  PubMed  |  Direct Link  |  

  119. Paolillo, M., A. Feliciello, A. Porcellini, C. Garbi and M. Bifulco et al., 1999. The type and the localization of cAMP-dependent protein kinase regulate transmission of cAMP signals to the nucleus in cortical and cerebellar granule cells. J. Biol. Chem., 274: 6546-6552.
    CrossRef  |  PubMed  |  Direct Link  |  

  120. Melck, D., T. Bisogno, L. De Petrocellis, H-H. Chuang, D. Julius, M. Bifulco and V. Di Marzo, 1999. Unsaturated long chain N-Acyl-Vanillyl-Amides (N-AVAMs).Vanilloid receptor ligands that inhibit anandamide facilitated transport and bind to CB1cannabinoid receptors. Biochem. Biophys. Res. Commun., 262: 275-284.
    CrossRef  |  Direct Link  |  

  121. Bifulco, M., C. Laezza and S.M. Aloj, 1999. Inhibition of farnesylation blocks growth but not differentiation in FRTL-5 thyroid cells. Biochimie, 81: 287-290.
    CrossRef  |  PubMed  |  Direct Link  |  

  122. Laezza, C., V. Di Marzo and M. Bifulco, 1998. V-K-ras leads to preferential farnesylation of p21ras in FRTL-5 cells: Multiple interference with the isoprenoid pathway. Proc. Natl. Acad. Sci., 95: 13646-13651.
    PubMed  |  

  123. Laezza, C., C. Bucci, M. Santillo, C.B. Bruni and M. Bifulco, 1998. Control of Rab5 and Rab7 expression by the isoprenoid pathway. Biochem. Biophys. Res. Commun., 248: 469-472.
    CrossRef  |  PubMed  |  Direct Link  |  

  124. De Petrocellis, L., D. Melck, A. Palmisano, T. Bisogno, C. Laezza, M. Bifulco and V. Di Marzo, 1998. The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation. Proc. Natl. Acad. Sci., 95: 8375-8380.

  125. Bucci, C., R. Seru, T. Annella, R. Vitelli, D. Lattero, M. Bifulco, P. Mondola and M. Santillo, 1998. Free fatty acids modulate LDL receptor activity in BHK-21 cells. Atherosclerosis, 137: 329-340.
    PubMed  |  

  126. Vitelli, R.,M. Santillo, D. Lattero, M. Chiariello, M. Bifulco, C.B. Bruni and C. Bucci, 1997. Role of the small GTP-ase Rab7 in the late endocytic pathway. J. Biol. Chem., 272: 4391-4397.

  127. Laezza, C., J. Wolff and M. Bifulco, 1997. Identification of a 48-kDa prenylated protein that associates with microtubules as 2',3'-cyclic nucleotide 3'-phosphodiesterase in FRTL-5 cells. FEBS Lett., 413: 260-264.
    CrossRef  |  PubMed  |  Direct Link  |  

  128. Laezza, C., A. Migliaro, R. Cerbone, I. Tedesco, M. Santillo, C. Garbi and M. Bifulco, 1997. N6-Isopentenyladenosine affects cAMP-dependent microfilament organization in FRTL-5 thyroid cells. Exp. Cell Res., 234: 178-182.
    CrossRef  |  Direct Link  |  

  129. Santillo, M., P. Mondola, A. Milone, A. Gioielli and M. Bifulco, 1996. Ascorbate administration to normal and cholesterol-fed rats inhibits in vitro TBARS formation in serum and liver homogenates. Life Sci., 58: 1104-1108.
    CrossRef  |  Direct Link  |  

  130. Santillo, M., P. Mondola, A. Gioielli, R. Seru and S. Iossa et al., 1996. Inhibitors of ras farnesylation revert the increased resistance to oxidative stress in K-ras transformed NIH 3T3 Cells. Biochem. Biophys. Res. Commun., 229: 739-745.
    CrossRef  |  Direct Link  |  

  131. Bonapace, J.M., R. Addeo, L. Altucci, L. Cicatiello and M. Bifulco et al., 1996. 17-Estradiol overcomes a G1 block induced by HMG-CoA reductase inhibitors and fosters cell cycle progression without inducing ERK- 1 and -2 MAP kinases activation Oncogene, 12: 753-763.

  132. Perillo, B., I. Tedesco, C. Laezza, M. Santillo, A. Romano, S.M. Aloj and M. Bifulco, 1995. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression in FRTL-5 cells. II. Down-regulation by v-K-ras oncogene. J. Biol. Chem., 270: 15237-15241.
    PubMed  |  

  133. Bifulco, M., B. Perillo, M. Saji, C. Laezza, I. Tedesco, L.D. Kohn and S.M. Aloj, 1995. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression in FRTL-5 cells. I. Identification and characterization of a cyclic AMP-responsive element in the rat reductase promoter. J. Biol. Chem., 270: 15231-15236.
    PubMed  |  

  134. Bifulco, M., C. Laezza, S.M. Aloj and C. Garbi, 1993. Mevalonate controls cytoskeleton organization and cell morphology in thyroid epithelial cells. J. Cell. Physiol., 155: 340-348.
    CrossRef  |  Direct Link  |  

  135. Santillo, M., P. Mondola, F. Santangelo, A. Belfiore and I. Tedesco et al., 1992. Characterization of the Low density lipoprotein receptor activity in buffalo rat liver (BRL-3A) cells. Comp. Biochem. Physiol. B Comp. Biochem., 101: 489-494.
    CrossRef  |  PubMed  |  Direct Link  |  

  136. Mondola, P., M. Santillo, F. Santangelo, A. Belfiore, P. Gambardella and M. Bifulco, 1992. Effects of a new calf thymus protein on 3-hydroxy-3-methylglutaryl-CoA reductase activity in rat (Rattus bubalus) hepatocyte cells (BRL-3A). Comp. Biochem. Physiol. B Comp. Biochem., 103: 431-434.
    CrossRef  |  Direct Link  |  

  137. Milone, A., M. Delfino, A. Piccirillo, G.M.P. Illiano, S.M. Aloj and M. Bifulco, 1991. Increased levels of DHEAS in serum of X-linked ichthyosis patients. J. Inherit. Metab. Dis., 14: 96-104.
    PubMed  |  

  138. Grieco, D., Z.H. Beg, A. Romano, M. Bifulco and S.M. Aloj, 1990. Cell cycle progression and 3-hydroxy-3-methylglutaryl coenzyme A reductase are regulated by thyrotropin in FRTL-5 rat thyroid cells. J. Biol. Chem., 265: 19343-19350.
    PubMed  |  

  139. Bifulco, M., M. Santillo, I. Tedesco, R. Zarrilli, C. Laezza, and S.M. Aloj, 1990. Thyrotropin modulates low density lipoprotein binding activity in FRTL-5 thyroid cells. J. Biol. Chem., 265: 19336-19342.
    PubMed  |  Direct Link  |  

  140. Mondola, P., M. Santillo, I. Tedesco, F. Santangelo, A. Belfiore and M. Bifulco, 1989. Thymus fraction (FIII) effect on cholesterol metabolism: modulation of the low density lipoprotein receptor pathway. Int. J. Biochem., 21: 627-630.

  141. Mondola, P., M. Santillo, F. Santangelo, C. Caporale, A. Belfiore and M. Bifulco, 1989. Purification and characterization of a calf thymus protein active on lipid metabolism. Int. J. Biochem., 21: 1009-1014.
    CrossRef  |  PubMed  |  Direct Link  |  

  142. Garbi, C., C. Zurzolo, M. Bifulco and L. Nitsch, 1988. Synthesis of extracellular matrix glycoproteins by a differentiated thyroid epithelial cell line. J. Cell Physiol., 135: 39-46.
    PubMed  |  

  143. Aloj, S.M., F. Beguinot, M. Bifulco and L.D. Kohn, 1988. Thyrotropin regulation of thyroid cell functions: mechanism and relationship to thyroid disease. Annali Istituto Superiore Sanita, 24: 117-128.

  144. Delfino, M., A. Piccirillo, M. Bifulco, A. Filla and G. Fabbrocini, 1987. Alterations in lipid and steroid metabolism in X-linked ichthyosis. Ital. Gen. Rev. Dermatol., 24: 247-250.

  145. Bifulco, M., I.M. Spitz, H.J. Hirsh, Z. Shorer and S.M. Aloj, 1987. High-molecular-weight serum thyrotropin revisited. N. Engl. J. Med., 316: 1609-1610.
    CrossRef  |  PubMed  |  Direct Link  |  

  146. Beguinot, F., L. Beguinot, D. Tramontano, C. Duilio and S. Formisano et al., 1987. Thyrotropin regulation of membrane lipid fluidity in the FRTL-5 thyroid cell line. Its relationship to cell growth and functional activity. J. Biol. Chem., 262: 1575-1582.
    PubMed  |  

  147. Bifulco, M., H.A. Saroff, L.D. Kohn and S.M. Aloj, 1985. Thyrotropin interaction with high-density lipoproteins. Biochem. Biophys. Acta Lipids Lipid Metab., 835: 191-200.
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