Hi, I am Carla Cicala, My LiveDNA is 39.6098
 
   
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Dr. Carla Cicala
 
Highest Degree: Ph.D. in Pharmaceutical Sciences from University of Naples Federico II, Italy
 
Institute: University of Naples Federico II, Italy
 
Area of Interest: Biomedical Sciences
  •   Physiopathology
  •   Inflammation
  •   Haemostasis
  •   Vascular Reactivity
 
URL: http://livedna.org/39.6098
 
My SELECTED Publications
1:   Accardo, A., G. Salsano, A. Morisco, M. Aurilio and A. Parisi et al., 2012. Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent. Int. J. Nanomed., 7: 2007-2017.
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2:   Accardo, A., R. Mansi, G. Salzano, A. Morisco and M. Aurilio et al., 2013. Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells. J. Drug Target., 21: 240-249.
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3:   Alfieri, A., A. Parisi, F. Maione, G. Grassia and S. Morello et al., 2012. Hyperresponsiveness to adenosine in sensitized Wistar rats over-expressing A 1 receptor. Eur. J. Pharmacol., 695: 120-125.
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4:   Alfieri, A., F. Maione, A. Bisio, G. Romussi, N. Mascolo and C. Cicala, 2007. Effect of a diterpenoid from Salvia Cinnabarina on arterial blood pressure in rats. Phytother. Res., 21: 690-692.
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5:   Bisio, A., G. Romussi, E. Russo, N. De Tommasi and N. Mascolo et al., 2008. Platelet antiaggregating activity and chemical constituents of Salvia x jamensis. J. Compton. Nat. Prod. Commun., 3: 881-884. 3: 881-884.
6:   Bonito, M.C., C. Cicala, M.C. Marcotullio, F. Maione and N. Mascolo, 2011. Biological activity of bicyclic and tricyclic diterpenoids from Salvia species of immediate pharmacological and pharmaceutical interest. Nat. Prod. Commun., 6: 1205-1215.
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7:   Bracci, A., A.G. Amat, F. Maione, C. Cicala, N. Mascolo and V. De Feo, 2012. Diuretic activity of Lophophytum leandri. Nat. Prod. Commun., 7: 33-34.
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8:   Bucci, M., F. Roviezzo, C. Cicala, A. Pinto and G. Cirino, 2002. 17-β-oestradiol-induced vasorelaxation in vitro is mediated by eNOS through hsp90 and akt/pkb dependent mechanism. Br. J. Pharmacol., 135: 1695-1700.
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9:   Bucci, M., F. Roviezzo, C. Cicala, W.C. Sessa and G. Cirino, 2000. Geldanamycin an inhibitor of heat shock protein 90 (Hsp90) mediated signal transduction has anti‐inflammatory effects and interacts with glucocorticoid receptor in vivo. Br. J. Pharmacol., 131: 13-16.
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10:   Bucci, M., F. Roviezzo, V. Brancaleone, M.I. Lin and A. Di Lorenzo et al., 2004. Diabetic mouse angiopathy is linked to progressive sympathetic receptor deletion coupled to an enhanced caveolin-1 expression. Arteriosclerosis Thrombosis Vascular Biol., 24: 721-726.
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11:   Carotenuto, A., E. Fattorusso, V. Lanzotti, S. Magno, V. de Feo and C. Cicala, 1997. The flavonoids ofAllium neapolitanum. Phytochemistry, 44: 949-957.
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12:   Carotenuto, A., V. de Feo, E. Fattorusso, V. Lanzotti, S. Magno and C. Cicala, 1995. The flavonoids of allium ursinum. Phytochemistry, 41: 531-536.
13:   Cicala, C. and A. Ialenti, 2013. Adenosine signaling in airways: Toward a promising antiasthmatic approach. Eur. J. Pharmacol., 714: 522-525.
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14:   Cicala, C. and G. Cirino, 1993. Phospholipase A2-induced hypotension in the rat and its pharmacological modulation. Gen. Pharmacol.: Vascular Syst., 24: 1197-1202.
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15:   Cicala, C. and G. Cirino, 1998. Linkage between inflammation and coagulation: An update on the molecular basis of the crosstalk. Life Sci., 62: 1817-1824.
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16:   Cicala, C., 2002. Protease activated receptor 2 and the cardiovascular system. Br. J. Pharmacol., 135: 14-20.
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17:   Cicala, C., A. Ianaro, S. Fiorucci, A. Calignano and M. Bucci et al., 2000. NO-naproxen modulates inflammation, nociception and downregulates T cell response in rat Freund's adjuvant arthritis. Br. J. Pharmacol., 130: 1399-1405.
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18:   Cicala, C., A. Pinto, M. Bucci, R. Sorrentino and B. Walker et al., 1999. Protease-Activated Receptor-2 Involvment in hypotension in normal and endotoxemic rats in vivo. Circulation, 99: 2590-2597.
19:   Cicala, C., C. Santacroce, H. Itoh, G.J. Douglas and C.P. Page, 1996. A study on rat platelet responsiveness following intravenous endotoxin administration. Life Sci., 60: PL31-PL38.
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20:   Cicala, C., D. Spina, S.D. Keir, B. Severino, R. Meli, C.P. Page and G. Cirino, 2001. Protective effect of a PAR2‐activating peptide on histamine‐induced bronchoconstriction in guinea-pig. Br. J. Pharmacol., 132: 1229-1234.
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21:   Cicala, C., G. Cirino, F.M. Maiello, N. Mascolo and F. Capasso, 1994. Essential fatty acid-deficient diet modifies PAF levels in stomach and duodenum of endotoxin-treated rats. J. Lipid med. Cell signalling, 9: 145-153.
PubMed  |  Direct Link  |  
22:   Cicala, C., M. Bucci, F. D'Acquisto, L. Parente and G. Cirino, 1997. Sequential release of TNFα and phospholipase A2 in a rat model of LPS-induced pleurisy. Med. Inflamm., 6: 211-215.
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23:   Cicala, C., M. Bucci, G. de Dominicis, P. Harriot, L. Sorrentino and G. Cirino, 1999. Bronchoconstrictor effect of thrombin and thrombin receptor activating peptide in guinea‐pigs in vivo. Br. J. Pharmacol., 126: 478-484.
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24:   Cicala, C., M.R. Bucci, J.M. Maraganore and G. Cirino, 1995. Hirulog effect in rat endotoxin shock. Life Sci., 57: PL307-PL313.
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25:   Cicala, C., S. Morello, A. Alfieri, V. Vellecco and S. Marzocco, 2007. Haemostatic imbalance following carrageenan-induced rat paw oedema. Eur. J. Pharmacol., 577: 156-161.
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26:   Cicala, C., S. Morello, C. Iorio, R. Capasso, F. Borrelli and N. Mascolo, 2003. Vascular effects of caffeic acid phenethyl ester (CAPE) on isolated rat thoracic aorta. Life Sci., 73: 73-80.
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27:   Cicala, C., S. Morello, V. Santagada, G. Caliendo, L. Sorrentino and G. Cirino, 2001. Pharmacological dissection of vascular effects caused by activation of protease-activated receptors 1 and 2 in anesthetized rats. FASEB J., 15: 1433-1435.
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28:   Cicala, C., S. Morello, V. Vellecco, B. Severino, L. Sorrentino and G. Cirino, 2003. Basal nitric oxide modulates vascular effects of a peptide activating protease-activated receptor 2. Cardiovascular Res., 60: 431-437.
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29:   Cirino, G. and C. Cicala, 1993. Human recombinant lipocortin 1 (annexin 1) has anticoagulant activity on human plasma in vitro. J. Lipid Med., 8: 81-86.
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30:   Cirino, G. and C. Cicala, 2003. Upregulation of proteinase‐activated receptors (PARs) and cardiovascular function. Drug Dev. Res., 60: 20-23.
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31:   Cirino, G., C. Cicala and L. Sorrentino, 1994. Human recombinant platelet phospholipase A2 exacerbates poly-L-arginine induced rat paw edema. Inflammation, 18: 59-66.
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32:   Cirino, G., C. Cicala, F. Mancuso, A.R. Baydoun and J.L. Wallace, 1995. Flurbinitroxybutylester: A novel anti-inflammatory drug has enhanced antithrombotic activity. Thrombosis Res., 79: 73-81.
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33:   Cirino, G., C. Cicala, L. Sorrentino and D. Regoli, 1991. Effect of bradykinin antagonists, NG-monomethyl-L-arginine and L-NG-nitro arginine on phospholipase A2 induced oedema in rat paw. Gen. Pharmacol., 22: 801-804.
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34:   Cirino, G., C. Cicala, L. Sorrentino and J.L., Browning, 1993. Human recombinant non pancreatic secreted platelet phospholipase A2 has anticoagulant activity in vitro on human plasma. Thromb. Res., 70: 337-342.
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35:   Cirino, G., C. Cicala, L. Sorrentino, F.M. Maiello and J.L. Browning, 1994. Recombinant secreted nonpancreatic phospholipase A2 induces a synovitis-like inflammation in the rat air pouch. J. Rheumatol., 21: 824-829.
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36:   Cirino, G., C. Cicala, L. Sorrentino, G. Ciliberto, G. Arpaia, M. Perretti and R.J. Flower, 1993. Anti‐inflammatory actions of an N‐terminal peptide from human lipocortin 1. Br. J. Pharmacol., 108: 573-574.
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37:   Cirino, G., C. Cicala, M. Bucci, L. Sorrentino, G. Ambrosini, G. DeDominicis and D.C. Altieri, 1997. Factor Xa as an interface between coagulation and inflammation. Molecular mimicry of factor Xa association with effector cell protease receptor-1 induces acute inflammation in vivo. J. Clin. Invest., 99: 2446-2451.
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38:   Cirino, G., C. Cicala, M.R. Bucci, L. Sorrentino, J.M. Maraganore and S.R. Stone, 1996. Thrombin functions as an inflammatory mediator through activation of its receptor. J. Exp. Med., 183: 821-827.
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39:   Cirino, G., C. Cicala, R. Sorrentino, L. Sorrentino, J.L. Browning and C.P. Page, 1994. Human recombinant phospholipase A2 inhibits platelet aggregation in vitro and in vivo in rat and guinea pig. Eur. J. Pharmacol., 252: 147-154.
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40:   Cirino, G., C. Napoli, M. Bucci and C. Cicala, 2000. Inflammation-coagulation network: Are serine protease receptors the knot? Trends pharmacol. Sci., 21: 170-172.
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41:   Cirino, G., M. Misasi, A. Loffredo, L. Sorrentino, P. Caivano, M. Bucci and C. Cicala, 1996. The synovial-like membrane at the bone interface in loose total hip replacements contains high levels of extracellular group II phospholipase A2. Life Sci., 59: PL81-PL86.
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42:   Cirino, G., R. Sorrentino, C. Cicala, L. Sorrentino and A. Pinto, 1995. Indomethacin and thromboxane A2/prostaglandin H2 antagonist SQ29,548 impair in vitro contractions of aortic rings of ex vivo-treated lipopolysaccharide rats. J. Lipid. Mediat. Cell Signal., 13: 177-187.
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43:   De Tommasi, N., F. de Simone, G. Cirino, C. Cicala and C. Pizza, 1991. Hypoglycemic effects of sesquiterpene glycosides and polyhydroxylated triterpenoids of Eriobotrya japonica. Planta Medica., 57: 414-416.
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44:   Fattorusso, E., V. Lanzotti, O. Taglialatela-Scafati and C. Cicala, 2001. The flavonoids of leek, Allium porrum. Phytochemistry, 57: 565-569.
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45:   Forte, G., R. Sorrentino, A. Montinaro, A. Luciano and I.M. Adcock et al., 2012. Inhibition of CD73 improves B cell-mediated anti-tumor immunity in a mouse model of melanoma. J. Immunol., 189: 2226-2233.
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46:   Ianaro, A., C. Cicala, A. Calignano, V. Koteliansky and P. Gotwals et al., 2000. Anti-very late antigen-1 monoclonal antibody modulates the development of secondary lesion and T-cell response in experimental arthritis. Lab. Invest., 80: 73-80.
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47:   Itoh, H., C. Cicala, G.J. Douglas and C.P. Page, 1996. Platelet accumulation induced by bacterial endotoxin in rats. Thrombosis Res., 83: 405-419.
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48:   Liu, J.T., W. Paul, M. Emerson, C. Cicala and C.P. Page, 1994. Thrombin inhibitors and anti-coagulants on thrombin-induced embolisation in rabbit cranial vasculature. Eur. J. Pharmacol., 264: 183-190.
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49:   Maddaluno, M., G. Grassia, M.V. Di Lauro, A. Parisi and F. Maione et al., 2012. Bindarit inhibits human coronary artery smooth muscle cell proliferation, migration and phenotypic switching. PloS One, Vol. 7. 10.1371/journal.pone.0047464.
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50:   Maione, F., C. Cicala, E. Liverani, N. Mascolo, M. Perretti and F. D'Acquisto, 2011. IL-17A increases ADP-induced platelet aggregation. Biochem. Biophys. Res. Commun., 408: 658-662.
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51:   Maione, F., C. Cicala, G. Musciacco, V. de Feo, A.G. Amat, A. Ialenti and N. Mascolo, 2013. Phenols, alkaloids and terpenes from medicinal plants with antihypertensive and vasorelaxant activities. A review of natural products as leads to potential therapeutic agents. Nat. Prod. Commun., 8: 539-544.
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52:   Maione, F., M.C. Bonito, M. Colucci, V. Cozzolino and A. Bisio et al., 2009. First evidence for an anxiolytic effect of a diterpenoid from Salvia cinnabarina. Nat. Prod. Commun., 4: 469-472.
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53:   Meli, R., G. Mattace, C. Cicala, E. Esposito, F. Fiorino and G. Cirino, 2001. Thrombin and PAR‐1 acitvating peptide increase iNOS expression in cytokine‐stimulated C6 glioma cells. J. Neurochemistry, 79: 556-563.
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54:   Morello, S., K. Ito, S. Yamamura, K.Y. Lee and E. Jazrawi et al., 2006. IL-1 beta and TNF-alpha regulation of the adenosine receptor (A2A) expression: Differential requirement for NF-kappa B binding to the proximal promoter. J. Immunol., 177: 7173-7183.
PubMed  |  
55:   Morello, S., V. Vellecco, A. Alfieri, N. Mascolo and C. Cicala, 2006. Vasorelaxant effect of the flavonoid galangin on isolated rat thoracic aorta. Life. Sci., 78: 825-830.
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56:   Morello, S., V. Vellecco, F. Roviezzo, P. Maffia, S. Cuzzocrea, G. Cirino and C. Cicala, 2005. A protective role for proteinase activated receptor 2 in airways of lipopolysaccharide-treated rats. Biochem. Pharmacol., 71: 223-230.
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57:   Napoli, C., C. Cicala, F.P. D'Armiento, F. Roviezzo and P. Somma et al., 1999. Beneficial effects of ACE-inhibition with zofenopril on plaque formation and low-density lipoprotein oxidation in watanabe heritable hyperlipidemic rabbits. Gen. Pharmacol.: Vascular Syst., 33: 467-477.
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58:   Napoli, C., C. Cicala, J.L. Wallace, F. de Nigris and V. Santagada et al., 2000. Protease-activated receptor-2 modulates myocardial ischemia-reperfusion injury in the rat heart. Proc. Nat. Acad. Sci., 97: 3678-3683.
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59:   Napoli, C., F. De Nigris, C. Cicala, J.L. Wallace and G. Caliendo et al., 2002. Protease-activated receptor-2 activation improves efficiency of experimental ischemic preconditioning. Am. J. Physiol. Heart Circ Physiol., 282: 2004-2010.
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60:   Papapetropoulos, A., P. Piccardoni, G. Cirino, M. Bucci and R. Sorrentino et al., 1998. Hypotension and inflammatory cytokine gene expression triggered by factor Xa-nitric oxide signaling. Proc. Nat. Acad. Sci., 95: 4738-4742.
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61:   Parisi, A., A. Alfieri, M. Mazzella, A. Mazzella and M. Scognamiglio et al., 2010. Protective effect of dimethylsulfoxide on acute myocardial infarction in rats. J. Cardiovascular Pharmacol., 55: 106-109.
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62:   Rosselli, S., A. Maggio, G. Bellone, C. Formisano and A. Basile et al., 2007. Antibacterial and anticoagulant activities of coumarins isolated from the flowers of Magydaris tomentosa. Planta Med., 73: 116-120.
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63:   Russo, P., I. Tedesco, M. Russo, G.L. Russo, A.Venezia and C. Cicala, 2001. Effects of dealcoholated red wine and its phenolic fractions on platelet aggregation. Nutr. Metab. Cardiovascular Dis., 11: 25-29.
64:   Santagada, V., G. Caliendo, B. Severino, E. Perissutti and F. Fiorino et al., 2002. Minimal structural requirements for agonist activity of PAR-2 activating peptides. Bioorg Med. Chem. Lett., 12: 21-24.
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65:   Wallace, J.L., B. Reuter, C. Cicala, W. McKnight, M. Grisham and G. Cirino, 1994. A diclofenac derivative without ulcerogenic properties. Eur. J. Pharmacol., 257: 249-255.
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66:   Wallace, J.L., B. Reuter, C. Cicala, W. McKnight, M.B. Grisham and G. Cirino, 1994. Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat. Gastroenterology, 107: 173-179.
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67:   Wallace, J.L., G. Cirino, C. Cicala, D.W. Anderson, D. Argentieri and R.J. Capetola, 1991. Comparison of the ulcerogenic properties of tepoxalin with those of non-steroidal anti-inflammatory drugs (NSAIDs). Agents Actions, 34: 247-250.
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