Dr. Carla  Cicala

Dr. Carla Cicala

Associate Professor
University of Naples Federico II, Italy


Highest Degree
Ph.D. in Pharmaceutical Sciences from University of Naples Federico II, Italy

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Area of Interest:

Biomedical Sciences
100%
Physiopathology
62%
Inflammation
90%
Haemostasis
75%
Drug Delivery
55%

Education

1994

Ph.D.

University of Naples Federico II, Italy

Pharmaceutical Sciences

Selected Publications

  1. Maione, F., C. Cicala, G. Musciacco, V. de Feo, A.G. Amat, A. Ialenti and N. Mascolo, 2013. Phenols, alkaloids and terpenes from medicinal plants with antihypertensive and vasorelaxant activities. A review of natural products as leads to potential therapeutic agents. Nat. Prod. Commun., 8: 539-544.
    Direct Link  |  

  2. Cicala, C. and A. Ialenti, 2013. Adenosine signaling in airways: Toward a promising antiasthmatic approach. Eur. J. Pharmacol., 714: 522-525.
    CrossRef  |  

  3. Accardo, A., R. Mansi, G. Salzano, A. Morisco and M. Aurilio et al., 2013. Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells. J. Drug Target., 21: 240-249.
    CrossRef  |  

  4. Maddaluno, M., G. Grassia, M.V. Di Lauro, A. Parisi and F. Maione et al., 2012. Bindarit inhibits human coronary artery smooth muscle cell proliferation, migration and phenotypic switching. PloS One, Vol. 7. 10.1371/journal.pone.0047464.
    CrossRef  |  

  5. Forte, G., R. Sorrentino, A. Montinaro, A. Luciano and I.M. Adcock et al., 2012. Inhibition of CD73 improves B cell-mediated anti-tumor immunity in a mouse model of melanoma. J. Immunol., 189: 2226-2233.
    CrossRef  |  

  6. Bracci, A., A.G. Amat, F. Maione, C. Cicala, N. Mascolo and V. De Feo, 2012. Diuretic activity of Lophophytum leandri. Nat. Prod. Commun., 7: 33-34.
    PubMed  |  

  7. Alfieri, A., A. Parisi, F. Maione, G. Grassia and S. Morello et al., 2012. Hyperresponsiveness to adenosine in sensitized Wistar rats over-expressing A 1 receptor. Eur. J. Pharmacol., 695: 120-125.
    CrossRef  |  

  8. Accardo, A., G. Salsano, A. Morisco, M. Aurilio and A. Parisi et al., 2012. Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent. Int. J. Nanomed., 7: 2007-2017.
    Direct Link  |  

  9. Maione, F., C. Cicala, E. Liverani, N. Mascolo, M. Perretti and F. D'Acquisto, 2011. IL-17A increases ADP-induced platelet aggregation. Biochem. Biophys. Res. Commun., 408: 658-662.
    CrossRef  |  

  10. Bonito, M.C., C. Cicala, M.C. Marcotullio, F. Maione and N. Mascolo, 2011. Biological activity of bicyclic and tricyclic diterpenoids from Salvia species of immediate pharmacological and pharmaceutical interest. Nat. Prod. Commun., 6: 1205-1215.
    Direct Link  |  

  11. Parisi, A., A. Alfieri, M. Mazzella, A. Mazzella and M. Scognamiglio et al., 2010. Protective effect of dimethylsulfoxide on acute myocardial infarction in rats. J. Cardiovascular Pharmacol., 55: 106-109.
    CrossRef  |  

  12. Maione, F., M.C. Bonito, M. Colucci, V. Cozzolino and A. Bisio et al., 2009. First evidence for an anxiolytic effect of a diterpenoid from Salvia cinnabarina. Nat. Prod. Commun., 4: 469-472.
    PubMed  |  

  13. Bisio, A., G. Romussi, E. Russo, N. De Tommasi and N. Mascolo et al., 2008. Platelet antiaggregating activity and chemical constituents of Salvia x jamensis. J. Compton. Nat. Prod. Commun., 3: 881-884. 3: 881-884.

  14. Rosselli, S., A. Maggio, G. Bellone, C. Formisano and A. Basile et al., 2007. Antibacterial and anticoagulant activities of coumarins isolated from the flowers of Magydaris tomentosa. Planta Med., 73: 116-120.
    CrossRef  |  

  15. Cicala, C., S. Morello, A. Alfieri, V. Vellecco and S. Marzocco, 2007. Haemostatic imbalance following carrageenan-induced rat paw oedema. Eur. J. Pharmacol., 577: 156-161.
    CrossRef  |  

  16. Alfieri, A., F. Maione, A. Bisio, G. Romussi, N. Mascolo and C. Cicala, 2007. Effect of a diterpenoid from Salvia Cinnabarina on arterial blood pressure in rats. Phytother. Res., 21: 690-692.
    CrossRef  |  

  17. Morello, S., V. Vellecco, A. Alfieri, N. Mascolo and C. Cicala, 2006. Vasorelaxant effect of the flavonoid galangin on isolated rat thoracic aorta. Life. Sci., 78: 825-830.
    CrossRef  |  

  18. Morello, S., K. Ito, S. Yamamura, K.Y. Lee and E. Jazrawi et al., 2006. IL-1 beta and TNF-alpha regulation of the adenosine receptor (A2A) expression: Differential requirement for NF-kappa B binding to the proximal promoter. J. Immunol., 177: 7173-7183.
    PubMed  |  

  19. Morello, S., V. Vellecco, F. Roviezzo, P. Maffia, S. Cuzzocrea, G. Cirino and C. Cicala, 2005. A protective role for proteinase activated receptor 2 in airways of lipopolysaccharide-treated rats. Biochem. Pharmacol., 71: 223-230.
    CrossRef  |  

  20. Bucci, M., F. Roviezzo, V. Brancaleone, M.I. Lin and A. Di Lorenzo et al., 2004. Diabetic mouse angiopathy is linked to progressive sympathetic receptor deletion coupled to an enhanced caveolin-1 expression. Arteriosclerosis Thrombosis Vascular Biol., 24: 721-726.
    CrossRef  |  

  21. Cirino, G. and C. Cicala, 2003. Upregulation of proteinase‐activated receptors (PARs) and cardiovascular function. Drug Dev. Res., 60: 20-23.
    CrossRef  |  

  22. Cicala, C., S. Morello, V. Vellecco, B. Severino, L. Sorrentino and G. Cirino, 2003. Basal nitric oxide modulates vascular effects of a peptide activating protease-activated receptor 2. Cardiovascular Res., 60: 431-437.
    CrossRef  |  

  23. Cicala, C., S. Morello, C. Iorio, R. Capasso, F. Borrelli and N. Mascolo, 2003. Vascular effects of caffeic acid phenethyl ester (CAPE) on isolated rat thoracic aorta. Life Sci., 73: 73-80.
    CrossRef  |  

  24. Santagada, V., G. Caliendo, B. Severino, E. Perissutti and F. Fiorino et al., 2002. Minimal structural requirements for agonist activity of PAR-2 activating peptides. Bioorg Med. Chem. Lett., 12: 21-24.
    CrossRef  |  

  25. Napoli, C., F. De Nigris, C. Cicala, J.L. Wallace and G. Caliendo et al., 2002. Protease-activated receptor-2 activation improves efficiency of experimental ischemic preconditioning. Am. J. Physiol. Heart Circ Physiol., 282: 2004-2010.
    PubMed  |  

  26. Cicala, C., 2002. Protease activated receptor 2 and the cardiovascular system. Br. J. Pharmacol., 135: 14-20.
    CrossRef  |  

  27. Bucci, M., F. Roviezzo, C. Cicala, A. Pinto and G. Cirino, 2002. 17-β-oestradiol-induced vasorelaxation in vitro is mediated by eNOS through hsp90 and akt/pkb dependent mechanism. Br. J. Pharmacol., 135: 1695-1700.
    CrossRef  |  

  28. Russo, P., I. Tedesco, M. Russo, G.L. Russo, A.Venezia and C. Cicala, 2001. Effects of dealcoholated red wine and its phenolic fractions on platelet aggregation. Nutr. Metab. Cardiovascular Dis., 11: 25-29.

  29. Meli, R., G. Mattace, C. Cicala, E. Esposito, F. Fiorino and G. Cirino, 2001. Thrombin and PAR‐1 acitvating peptide increase iNOS expression in cytokine‐stimulated C6 glioma cells. J. Neurochemistry, 79: 556-563.
    CrossRef  |  

  30. Fattorusso, E., V. Lanzotti, O. Taglialatela-Scafati and C. Cicala, 2001. The flavonoids of leek, Allium porrum. Phytochemistry, 57: 565-569.
    CrossRef  |  

  31. Cicala, C., S. Morello, V. Santagada, G. Caliendo, L. Sorrentino and G. Cirino, 2001. Pharmacological dissection of vascular effects caused by activation of protease-activated receptors 1 and 2 in anesthetized rats. FASEB J., 15: 1433-1435.
    CrossRef  |  

  32. Cicala, C., D. Spina, S.D. Keir, B. Severino, R. Meli, C.P. Page and G. Cirino, 2001. Protective effect of a PAR2‐activating peptide on histamine‐induced bronchoconstriction in guinea-pig. Br. J. Pharmacol., 132: 1229-1234.
    CrossRef  |  

  33. Napoli, C., C. Cicala, J.L. Wallace, F. de Nigris and V. Santagada et al., 2000. Protease-activated receptor-2 modulates myocardial ischemia-reperfusion injury in the rat heart. Proc. Nat. Acad. Sci., 97: 3678-3683.
    Direct Link  |  

  34. Ianaro, A., C. Cicala, A. Calignano, V. Koteliansky and P. Gotwals et al., 2000. Anti-very late antigen-1 monoclonal antibody modulates the development of secondary lesion and T-cell response in experimental arthritis. Lab. Invest., 80: 73-80.
    Direct Link  |  

  35. Cirino, G., C. Napoli, M. Bucci and C. Cicala, 2000. Inflammation-coagulation network: Are serine protease receptors the knot? Trends pharmacol. Sci., 21: 170-172.
    Direct Link  |  

  36. Cicala, C., A. Ianaro, S. Fiorucci, A. Calignano and M. Bucci et al., 2000. NO-naproxen modulates inflammation, nociception and downregulates T cell response in rat Freund's adjuvant arthritis. Br. J. Pharmacol., 130: 1399-1405.
    CrossRef  |  Direct Link  |  

  37. Bucci, M., F. Roviezzo, C. Cicala, W.C. Sessa and G. Cirino, 2000. Geldanamycin an inhibitor of heat shock protein 90 (Hsp90) mediated signal transduction has anti‐inflammatory effects and interacts with glucocorticoid receptor in vivo. Br. J. Pharmacol., 131: 13-16.
    CrossRef  |  

  38. Napoli, C., C. Cicala, F.P. D'Armiento, F. Roviezzo and P. Somma et al., 1999. Beneficial effects of ACE-inhibition with zofenopril on plaque formation and low-density lipoprotein oxidation in watanabe heritable hyperlipidemic rabbits. Gen. Pharmacol.: Vascular Syst., 33: 467-477.
    CrossRef  |  Direct Link  |  

  39. Cicala, C., M. Bucci, G. de Dominicis, P. Harriot, L. Sorrentino and G. Cirino, 1999. Bronchoconstrictor effect of thrombin and thrombin receptor activating peptide in guinea‐pigs in vivo. Br. J. Pharmacol., 126: 478-484.
    CrossRef  |  

  40. Cicala, C., A. Pinto, M. Bucci, R. Sorrentino and B. Walker et al., 1999. Protease-Activated Receptor-2 Involvment in hypotension in normal and endotoxemic rats in vivo. Circulation, 99: 2590-2597.

  41. Papapetropoulos, A., P. Piccardoni, G. Cirino, M. Bucci and R. Sorrentino et al., 1998. Hypotension and inflammatory cytokine gene expression triggered by factor Xa-nitric oxide signaling. Proc. Nat. Acad. Sci., 95: 4738-4742.
    Direct Link  |  

  42. Cicala, C. and G. Cirino, 1998. Linkage between inflammation and coagulation: An update on the molecular basis of the crosstalk. Life Sci., 62: 1817-1824.
    CrossRef  |  Direct Link  |  

  43. Cirino, G., C. Cicala, M. Bucci, L. Sorrentino, G. Ambrosini, G. DeDominicis and D.C. Altieri, 1997. Factor Xa as an interface between coagulation and inflammation. Molecular mimicry of factor Xa association with effector cell protease receptor-1 induces acute inflammation in vivo. J. Clin. Invest., 99: 2446-2451.
    CrossRef  |  Direct Link  |  

  44. Cicala, C., M. Bucci, F. D'Acquisto, L. Parente and G. Cirino, 1997. Sequential release of TNFα and phospholipase A2 in a rat model of LPS-induced pleurisy. Med. Inflamm., 6: 211-215.
    CrossRef  |  

  45. Carotenuto, A., E. Fattorusso, V. Lanzotti, S. Magno, V. de Feo and C. Cicala, 1997. The flavonoids ofAllium neapolitanum. Phytochemistry, 44: 949-957.
    CrossRef  |  

  46. Itoh, H., C. Cicala, G.J. Douglas and C.P. Page, 1996. Platelet accumulation induced by bacterial endotoxin in rats. Thrombosis Res., 83: 405-419.
    CrossRef  |  Direct Link  |  

  47. Cirino, G., M. Misasi, A. Loffredo, L. Sorrentino, P. Caivano, M. Bucci and C. Cicala, 1996. The synovial-like membrane at the bone interface in loose total hip replacements contains high levels of extracellular group II phospholipase A2. Life Sci., 59: PL81-PL86.
    PubMed  |  Direct Link  |  

  48. Cirino, G., C. Cicala, M.R. Bucci, L. Sorrentino, J.M. Maraganore and S.R. Stone, 1996. Thrombin functions as an inflammatory mediator through activation of its receptor. J. Exp. Med., 183: 821-827.
    CrossRef  |  

  49. Cicala, C., C. Santacroce, H. Itoh, G.J. Douglas and C.P. Page, 1996. A study on rat platelet responsiveness following intravenous endotoxin administration. Life Sci., 60: PL31-PL38.
    CrossRef  |  Direct Link  |  

  50. Cirino, G., R. Sorrentino, C. Cicala, L. Sorrentino and A. Pinto, 1995. Indomethacin and thromboxane A2/prostaglandin H2 antagonist SQ29,548 impair in vitro contractions of aortic rings of ex vivo-treated lipopolysaccharide rats. J. Lipid. Mediat. Cell Signal., 13: 177-187.
    PubMed  |  Direct Link  |  

  51. Cirino, G., C. Cicala, F. Mancuso, A.R. Baydoun and J.L. Wallace, 1995. Flurbinitroxybutylester: A novel anti-inflammatory drug has enhanced antithrombotic activity. Thrombosis Res., 79: 73-81.
    CrossRef  |  Direct Link  |  

  52. Cicala, C., M.R. Bucci, J.M. Maraganore and G. Cirino, 1995. Hirulog effect in rat endotoxin shock. Life Sci., 57: PL307-PL313.
    CrossRef  |  Direct Link  |  

  53. Carotenuto, A., V. de Feo, E. Fattorusso, V. Lanzotti, S. Magno and C. Cicala, 1995. The flavonoids of allium ursinum. Phytochemistry, 41: 531-536.

  54. Wallace, J.L., B. Reuter, C. Cicala, W. McKnight, M.B. Grisham and G. Cirino, 1994. Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat. Gastroenterology, 107: 173-179.
    PubMed  |  Direct Link  |  

  55. Wallace, J.L., B. Reuter, C. Cicala, W. McKnight, M. Grisham and G. Cirino, 1994. A diclofenac derivative without ulcerogenic properties. Eur. J. Pharmacol., 257: 249-255.
    CrossRef  |  Direct Link  |  

  56. Liu, J.T., W. Paul, M. Emerson, C. Cicala and C.P. Page, 1994. Thrombin inhibitors and anti-coagulants on thrombin-induced embolisation in rabbit cranial vasculature. Eur. J. Pharmacol., 264: 183-190.
    CrossRef  |  

  57. Cirino, G., C. Cicala, R. Sorrentino, L. Sorrentino, J.L. Browning and C.P. Page, 1994. Human recombinant phospholipase A2 inhibits platelet aggregation in vitro and in vivo in rat and guinea pig. Eur. J. Pharmacol., 252: 147-154.
    PubMed  |  Direct Link  |  

  58. Cirino, G., C. Cicala, L. Sorrentino, F.M. Maiello and J.L. Browning, 1994. Recombinant secreted nonpancreatic phospholipase A2 induces a synovitis-like inflammation in the rat air pouch. J. Rheumatol., 21: 824-829.
    PubMed  |  Direct Link  |  

  59. Cirino, G., C. Cicala and L. Sorrentino, 1994. Human recombinant platelet phospholipase A2 exacerbates poly-L-arginine induced rat paw edema. Inflammation, 18: 59-66.
    CrossRef  |  

  60. Cicala, C., G. Cirino, F.M. Maiello, N. Mascolo and F. Capasso, 1994. Essential fatty acid-deficient diet modifies PAF levels in stomach and duodenum of endotoxin-treated rats. J. Lipid med. Cell signalling, 9: 145-153.
    PubMed  |  Direct Link  |  

  61. Cirino, G., C. Cicala, L. Sorrentino, G. Ciliberto, G. Arpaia, M. Perretti and R.J. Flower, 1993. Anti‐inflammatory actions of an N‐terminal peptide from human lipocortin 1. Br. J. Pharmacol., 108: 573-574.
    CrossRef  |  

  62. Cirino, G., C. Cicala, L. Sorrentino and J.L., Browning, 1993. Human recombinant non pancreatic secreted platelet phospholipase A2 has anticoagulant activity in vitro on human plasma. Thromb. Res., 70: 337-342.
    PubMed  |  Direct Link  |  

  63. Cirino, G. and C. Cicala, 1993. Human recombinant lipocortin 1 (annexin 1) has anticoagulant activity on human plasma in vitro. J. Lipid Med., 8: 81-86.
    Direct Link  |  

  64. Cicala, C. and G. Cirino, 1993. Phospholipase A2-induced hypotension in the rat and its pharmacological modulation. Gen. Pharmacol.: Vascular Syst., 24: 1197-1202.
    CrossRef  |  

  65. Wallace, J.L., G. Cirino, C. Cicala, D.W. Anderson, D. Argentieri and R.J. Capetola, 1991. Comparison of the ulcerogenic properties of tepoxalin with those of non-steroidal anti-inflammatory drugs (NSAIDs). Agents Actions, 34: 247-250.
    CrossRef  |  

  66. De Tommasi, N., F. de Simone, G. Cirino, C. Cicala and C. Pizza, 1991. Hypoglycemic effects of sesquiterpene glycosides and polyhydroxylated triterpenoids of Eriobotrya japonica. Planta Medica., 57: 414-416.
    CrossRef  |  

  67. Cirino, G., C. Cicala, L. Sorrentino and D. Regoli, 1991. Effect of bradykinin antagonists, NG-monomethyl-L-arginine and L-NG-nitro arginine on phospholipase A2 induced oedema in rat paw. Gen. Pharmacol., 22: 801-804.
    PubMed  |  Direct Link  |