Dr. Rosalinda  Sorrentino

Dr. Rosalinda Sorrentino

Research Scientist
University of Salerno, Italy


Highest Degree
Ph.D. in Drug Science from University of Naples Federico II, Italy

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Area of Interest:

Pharmacology and Toxicology
100%
Oncoimmunology
62%
Pharmacology
90%
Immunology
75%
Cellular Physiology
55%

Selected Publications

  1. Spaziano, G., R. Sorrentino, M. Matteis, G. Malgieri and M. Sgambato et al., 2017. Nociceptin reduces the inflammatory immune microenvironment in a conventional murine model of airway hyperresponsiveness. Clin. Exp. Allergy, 47: 208-216.
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  2. De Falco, G., M. Terlizzi, M. Sirignano, M. Commodo and A. D'Anna et al., 2017. Human Peripheral Blood Mononuclear Cells (PBMCs) from smokers release higher levels of IL-1-like cytokines after exposure to combustion-generated ultrafine particles. Scient. Rep., Vol. 7. 10.1038/srep43016.
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  3. Terlizzi, M., C. Colarusso, A. Popolo, A. Pinto and R. Sorrentino, 2016. IL-1α and IL-1β-producing macrophages populate lung tumor lesions in mice. Oncotarget, 7: 58181-58192.
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  4. Roviezzo, F., R. Sorrentino, V.M. Iacono, V. Brancaleone and M. Terlizzi et al., 2016. Disodium cromoglycate inhibits asthma-like features induced by sphingosine-1-phosphate. Pharmacol. Res., 113: 626-635.
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  5. Pecoraro, M., M. Del Pizzo, S. Marzocco, R. Sorrentino and M. Ciccarelli et al., 2016. Inflammatory mediators in a short-time mouse model of doxorubicin-induced cardiotoxicity. Toxicol. Applied Pharmacol., 293: 44-52.
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  6. Terlizzi, M., V.G. Di Crescenzo, G. Perillo, A. Galderisi, A. Pinto and R. Sorrentino, 2015. Pharmacological inhibition of caspase-8 limits lung tumour outgrowth. Br. J. Pharmacol., 172: 3917-3928.
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  7. Sorrentino, R., M. Terlizzi, V.G. Di Crescenzo, A. Popolo and M. Pecoraro et al., 2015. Human lung cancer-derived immunosuppressive plasmacytoid dendritic cells release IL-1α in an AIM2 inflammasome-dependent manner. Am. J. Pathol., 185: 3115-3124.
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  8. Sorrentino, R., A. Yilmaz, K. Schubert, T.R. Crother and A. Pinto et al., 2015. A single infection with Chlamydia pneumoniae is sufficient to exacerbate atherosclerosis in ApoE deficient mice. Cell. Immunol., 294: 25-32.
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  9. Sorrentino, R., A. Bertolino, M. Terlizzi, V.M. Iacono and P. Maiolino et al., 2015. B cell depletion increases sphingosine-1-phosphate-dependent airway inflammation in mice. Am. J. Respir. Cell Mol. Biol., 52: 571-583.
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  10. Roviezzo, F., R. Sorrentino, A. Bertolino, L. De Gruttola and M. Terlizzi et al., 2015. S1P-induced airway smooth muscle hyperresponsiveness and lung inflammation in vivo: Molecular and cellular mechanisms. Br. J. Pharmacol., 172: 1882-1893.
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  11. Roviezzo, F., A. Bertolino, R. Sorrentino, M. Terlizzi and M. Matteis et al., 2015. Hydrogen sulfide inhalation ameliorates allergen induced airway hypereactivity by modulating mast cell activation. Pharmacol. Res., 100: 85-92.
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  12. Terlizzi, M., V. Casolaro, A. Pinto and R. Sorrentino, 2014. Inflammasome: Cancer's friend or foe? Pharmacol. Therapeut., 143: 24-33.
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  13. Terlizzi, M., A. Popolo, A. Pinto and R. Sorrentino, 2014. Plasmacytoid dendritic cells contribute to doxorubicin-induced tumor arrest in a mouse model of pulmonary metastasis. J. Immunother., 37: 214-224.
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  14. Sorrentino, R., A. Pinto and S. Morello, 2013. The adenosinergic system in cancer: Key therapeutic target. Oncoimmunology, Vol. 2, No. 1. 10.4161/onci.22448.
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  15. Rega, A., M. Terlizzi, A. Luciano, G. Forte and T.R. Crother et al., 2013. Plasmacytoid dendritic cells play a key role in tumor progression in lipopolysaccharide-stimulated lung tumor-bearing mice. J. Immunol., 190: 2391-2402.
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  16. Popolo, A., S. Morello, R. Sorrentino and A. Pinto, 2013. Antiadrenergic effect of adenosine involves connexin 43 turn-over in H9c2 cells. Eur. J. Pharmacol., 715: 56-61.
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  17. Adesso, S., A. Popolo, G. Bianco, R. Sorrentino, A. Pinto, G. Autore and S. Marzocco, 2013. The uremic toxin indoxyl sulphate enhances macrophage response to LPS. PLoS ONE, Vol. 8. 10.1371/journal.pone.0076778.
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  18. Pinto, A., A. Rega, T.R. Crother and R. Sorrentino, 2012. Plasmacytoid dendritic cells and their therapeutic activity in cancer. Oncoimmunology, 1: 726-734.
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  19. Montinaro, A., G. Forte, R. Sorrentino, A. Luciano and G. Palma et al., 2012. Adoptive immunotherapy with Cl-IB-MECA-treated CD8+ T cells reduces melanoma growth in mice. PLoS ONE, Vol. 7. 10.1371/journal.pone.0045401.
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  20. Forte, G., R. Sorrentino, A. Montinaro, A. Luciano and I.M. Adcock et al., 2012. Inhibition of CD73 improves B cell-mediated anti-tumor immunity in a mouse model of melanoma. J. Immunol., 189: 2226-2233.
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  21. Forte, G., A. Rega, S. Morello, A. Luciano, C. Arra, A. Pinto and R. Sorrentino, 2012. Polyinosinic-polycytidylic acid limits tumor outgrowth in a mouse model of metastatic lung cancer. J. Immunol., 188: 5357-5364.
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  22. Sorrentino, R., S. Morello, M.G. Giordano, C. Arra, P. Maiolino, I.M. Adcock and A. Pinto, 2011. CpG-ODN increases the release of VEGF in a mouse model of lung carcinoma. Int. J. Cancer, 128: 2815-2822.
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  23. Sorrentino, R., S. Morello, G. Forte, A. Montinaro and G. De Vita et al., 2011. B cells contribute to the antitumor activity of CpG-oligodeoxynucleotide in a mouse model of metastatic lung carcinoma. Am. J. Respir. Crit. Care Med., 183: 1369-1379.
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  24. Popolo, A., A.L. Piccinelli, S. Morello, R. Sorrentino, C.R. Osmany, L. Rastrelli and P. Aldo, 2011. Cytotoxic activity of nemorosone in human MCF-7 breast cancer cells. Can. J. Physiol. Pharmacol., 89: 50-57.
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  25. Pinto, A., S. Morello and R. Sorrentino, 2011. Lung cancer and toll-like receptors. Cancer Immunol. Immunother., 60: 1211-1220.
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  26. Morello, S., R. Sorrentino, A. Montinaro, A. Luciano and P. Maiolino et al., 2011. NK1.1 cells and CD8 T cells mediate the antitumor activity of Cl-IB-MECA in a mouse melanoma model. Neoplasia, 13: 365-373.
    PubMed  |  Direct Link  |  

  27. Forte, G., R. Sorrentino, A. Montinaro, A. Pinto and S. Morello, 2011. Cl-IB-MECA enhances TNF-α release in peritoneal macrophages stimulated with LPS. Cytokine, 54: 161-166.
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  28. Di Villa Bianca, R.E., R. Sorrentino, C. Coletta, E. Mitidieri and A. Rossi et al., 2011. Hydrogen sulfide-induced dual vascular effect involves arachidonic acid cascade in rat mesenteric arterial bed. J. Pharmacol. Exp. Ther., 337: 59-64.
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  29. Sorrentino, R., S. Morello, S. Chen, E. Bonavita and A. Pinto, 2010. The activation of liver X receptors inhibits toll-like receptor-9-induced foam cell formation. J. Cell. Physiol., 223: 158-167.
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  30. Sorrentino, R., S. Morello, A. Luciano, T.R. Crother and P. Maiolino et al., 2010. Plasmacytoid dendritic cells alter the antitumor activity of CpG-oligodeoxynucleotides in a mouse model of lung carcinoma. J. Immunol., 185: 4641-4650.
    CrossRef  |  Direct Link  |  

  31. Sorrentino, R., S. Morello and A. Pinto, 2010. Role of plasmacytoid dendritic cells in lung-associated inflammation. Recent Patents Inflam. Allergy Drug Discovery, 4: 138-143.
    CrossRef  |  

  32. Sorrentino, R., S. Morello and A. Pinto, 2010. Plasmacytoid dendritic cells: From heart to vessels. Int. J. Vasc. Med. 10.1155/2010/430318.
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  33. Sorrentino, R., P. Gray, S. Chen, K. Shimada, T.R. Crother and M. Arditi, 2010. Plasmacytoid dendritic cells prevent cigarette smoke and Chlamydophila pneumoniae-induced Th2 inflammatory responses. Am. J. Respir. Cell Mol. Biol., 43: 422-431.
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  34. Sorrentino, R. and M. Arditi, 2009. Innate Immunity, Toll-Like Receptors and Atherosclerosis: Mouse Models and Methods. In: Toll-Like Receptors: Methods and Protocols, McCoy, C.E. and L.A.J. O'Neill (Eds.). Chapter 23, Springer, New York, USA., ISBN-13: 9781934115725, pp: 381-399.

  35. Shimada, K., S. Chen, P.W. Dempsey, R. Sorrentino and R. Alsabeh et al., 2009. The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection. PLoS Pathogen, Vol. 5. 10.1371/journal.ppat.1000379.
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  36. Schulte, D.J., A. Yilmaz, K. Shimada, M. Fishbein and E.L. Lowe et al., 2009. Involvement of innate and adaptive immunity in a murine model of coronary arteritis mimicking Kawasaki disease. J. Immunol., 183: 5311-5318.
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  37. Popolo, A., L.A. Piccinelli, S. Morello, O. Cuesta-Rubio, R. Sorrentino, L. Rastrelli and A. Pinto, 2009. Antiproliferative activity of brown Cuban propolis extract on human breast cancer cells. Nat. Prod. Commun., 4: 1711-1716.
    PubMed  |  

  38. Paul-Clark, M.J., S.K. McMaster, R. Sorrentino, S. Sriskandan and L.K. Bailey, 2009. Toll-like receptor 2 is essential for the sensing of oxidants during inflammation. Am. J. Respir. Crit. Care, 179: 299-306.
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  39. Morello, S., R. Sorrentino, A. Porta, G. Forte, A. Popolo, A. Petrella and A. Pinto, 2009. Cl-IB-MECA enhances TRAIL-induced apoptosis via the modulation of NF-κB signalling pathway in thyroid cancer cells. J. Cell. Physiol., 221: 378-386.
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  40. Morello, S., R. Sorrentino and A. Pinto, 2009. Adenosine A2a receptor agonists as regulators of inflammation: Pharmacology and therapeutic opportunities. J. Receptor Ligand Channel Res., 2: 11-17.
    Direct Link  |  

  41. Mitchell, J.A., R. Sorrentino, N. Cartwright and M.J. Paul-Clark, 2009. Toll-Like Receptor 2 as Therapeutic Target in Lung Disease. In: New Drugs and Targets for Asthma and COPD (Progress in Respiratory Research, Vol. 39), Hansel, T.T. and P.J. Barnes (Eds.). Karger Publisher, Basel, Switzerland, pp: 69-72.

  42. Di Villa Bianca, R.E., R. Sorrentino, E. Mitidieri, S. Marzocco and G. Autore et al., 2009. Recombinant human erythropoietin prevents lipopolysaccharide-induced vascular hyporeactivity in the rat. Shock, 31: 529-534.
    CrossRef  |  PubMed  |  

  43. Sorrentino, R., P.M. De Souza, S. Sriskandan, C. Duffin, M.J. Paul-Clark and J.A. Mitchell, 2008. Pattern recognition receptors and interleukin-8 mediate effects of Gram-positive and Gram-negative bacteria on lung epithelial cell function. Br. J. Pharmacol., 154: 864-871.
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  44. Paul-Clark, M.J., R. Sorrentino, L.K. Bailey, S. Sriskandan and J.A. Mitchell, 2008. Gram-positive and Gram-negative bacteria synergize with oxidants to release CXCL8 from innate immune cells. Mol. Med., 14: 238-246.
    PubMed  |  Direct Link  |  

  45. Naiki, Y., R. Sorrentino, M.H. Wong, K.S. Michelsen and K. Shimada et al., 2008. TLR/MyD88 and liver X receptor α signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis. J. Immunol., 181: 7176-7185.
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  46. Issa, R., R. Sorrentino, M.B. Sukkar, S. Sriskandan, K.F. Chung and J.A. Mitchell, 2008. Differential regulation of CCL-11/eotaxin-1 and CXCL-8/IL-8 by Gram-positive and Gram-negative bacteria in human airway smooth muscle cells. Respir. Res., Vol. 9. 10.1186/1465-9921-9-30.
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  47. Chen, S., R. Sorrentino, K. Shimada, Y. Bulut, T.M. Doherty, T.R. Crother and M. Arditi, 2008. Chlamydia pneumoniae-induced foam cell formation requires MyD88-dependent and -independent signaling and is reciprocally modulated by liver X receptor activation. J. Immunol., 181: 7186-7193.
    PubMed  |  Direct Link  |  

  48. Cartwright, N., S.K McMaster, R. Sorrentino, M.J. Paul-Clark and S. Sriskandan et al., 2007. Elucidation of toll-like receptor and adapter protein signaling in vascular dysfunction induced by Gram-positive Staphylococcus aureus or Gram-negative Escherichia coli. Shock, 27: 40-47.
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  49. Paul-Clark, M.J., S.K. McMaster, E. Belcher, R. Sorrentino and J. Anandarajah et al., 2006. Differential effects of Gram-positive versus Gram-negative bacteria on NOSII and TNFα in macrophages: Role of TLRs in synergy between the two. Br. J. Pharmacol., 148: 1067-1075.
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  50. Di Villa Bianca, R.E., R. Sorrentino, R. Sorrentino, C. Imbimbo and A. Palmieri et al., 2006. Sphingosine 1-phosphate induces endothelial nitric-oxide synthase activation through phosphorylation in human corpus cavernosum. J. Pharmacol. Exp. Therapy, 316: 703-708.
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