Biography

Dr. Bauer has been an Assistant Professor at the College of Pharmacy, the University of Minnesota since 2007. He received a B.S. in Pharmacy, a Ph.D. in Pharmaceutical Sciences/Pharmacology from the University of Heidelberg, Germany, and was a Postdoctoral Fellow at NIEHS/NIH in Research Triangle Park, NC.

Dr. Bauers research focus is on the regulation of blood-brain barrier transporters in CNS disease.

Area of Interest:

Pharmacology and Toxicology

100%

Pharmaceutical Analysis

62%

Blood-Brain Barrier

90%

Pharmacodynamic

75%

Physiology

55%

Research Publications in Numbers

Books
0

Chapters
0

Articles
56

Abstracts
0

Selected Publications

Hartz, A.M.S. and B. Bauer, 2011. ABC Transporters in the CNS - An Inventory. Curr. Pharm. Biotechnol., 12: 656-673.
CrossRef | PubMed |
Hartz, A.M.S., E.K. Madole, D.S. Miller and B. Bauer, 2010. Estrogen receptor β signaling through phosphatase and tensin homolog/phosphoinositide 3-kinase/akt/glycogen synthase kinase 3 down-regulates blood-brain barrier breast cancer resistance protein. J. Pharmacol. Exp. Ther., 334: 467-476.
CrossRef | PubMed | Direct Link |
Hartz, A.M.S., D.S. Miller and B. Bauer, 2010. Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-β in a mouse model of Alzheimer`s disease. Mol. Pharmacol., 77: 715-723.
CrossRef | PubMed | Direct Link |
Hartz, A.M.S., A. Mahringer, D.S. Miller and B. Bauer, 2010. 17-β-estradiol: A powerful modulator of blood-brain barrier BCRP activity. J. Cerebral Blood Flow Metab., 30: 1742-1755.
CrossRef | PubMed | Direct Link |
Hartz, A.M.S. and B. Bauer, 2010. Regulation of ABC transporters at the blood-brain barrier: New targets for CNS therapy. Mol. Interv., 10: 293-304.
CrossRef | PubMed | Direct Link |
Miller, D.S., B. Bauer and A.M.S. Hartz, 2008. Modulation of P-glycoprotein at the blood-brain barrier: Opportunities to improve Central nervous system pharmacotherapy. Pharmacol. Rev., 60: 196-209.
CrossRef | PubMed | Direct Link |
Hartz, A.M.S., B. Bauer, M.L. Block, J.S. Hong and D.S. Miller, 2008. Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier. FASEB J., 22: 2723-2733.
CrossRef | PubMed | Direct Link |
Bauer, B., A.M.S. Hartz, J.R. Lucking, X. Yang, G.M. Pollack and D.S. Miller, 2008. Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTπ, at the blood-brain barrier. J. Cerebral Blood Flow Metab., 28: 1222-1234.
CrossRef | PubMed | Direct Link |
Bauer, B., A.M.S. Hartz, A. Pekcec, K. Toellner, D.S. Miller and H. Potschka, 2008. Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling. Mol. Pharmacol., 73: 1444-1453.
CrossRef | PubMed | Direct Link |
Bauer, B., A.M.S. Hartz and D.S. Miller, 2007. Tumor necrosis factor α and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier. Mol. Pharmacol., 71: 667-675.
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Bauer, B., X. Yang, A.M.S. Hartz, E.R. Olson and R. Zhao et al., 2006. In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation. Mol. Pharmacol., 70: 1212-1219.
CrossRef | PubMed | Direct Link |
Bauer, B., A.M.S. Hartz, G. Fricker and D.S. Miller, 2004. Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier. Mol. Pharmacol., 66: 413-419.
PubMed | Direct Link |
Fellner, S., B. Bauer, D.S. Miller, M. Schaffrik and M. Fankhanel et al., 2002. Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo. J. Clin. Invest., 110: 1309-1318.
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