Prof. Dr. Dagmar Kulms
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Prof. Dr. Dagmar Kulms

Professor
University Hospital Dresden, Germany

Highest Degree
Ph.D. in Biology from University of Giessen, Germany

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Area of Interest:

Pharmacology and Toxicology
100%
Dermatological Therapeutics
62%
Biochemical Pharmacology
90%
Phytochemistry
75%
Cancer Research
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Niessner, H., T. Sinnberg, C. Kosnopfel, K.S. Smalley and D. Beck et al., 2017. BRAF inhibitors amplify the proapoptotic activity of MEK inhibitors by inducing ER stress in NRAS-mutant melanoma. Clin. Cancer Res., 10.1158/1078-0432.CCR-17-0098.
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  2. Hutt, M., L. Marquardt, O. Seifert, M. Siegemund and I. Muller et al., 2017. Superior properties of Fc-comprising scTRAIL fusion proteins. Mol. Cancer Ther., 10.1158/1535-7163.MCT-17-0551.
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  3. Niessner, H., J. Schmitz, G. Tabatabai, A.M. Schmid and C. Calaminus et al., 2016. PI3K pathway inhibition achieves potent antitumor activity in melanoma brain metastases in vitro and in vivo. Clin. Cancer Res., 10.1158/1078-0432.CCR-16-0064.
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  4. Henry, C.M., G.P. Sullivan, D.M. Clancy, I.S. Afonina, D. Kulms and S.J. Martin, 2016. Neutrophil-derived proteases escalate inflammation through activation of IL-36 family cytokines. Cell Rep., 14: 708-722.
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  5. Muller, I., S. Beissert and D. Kulms, 2015. Anti-Apoptotic NF-κB and “Gain of Function” mutp53 in concert act pro-apoptotic in response to UVB+ IL-1 via enhanced TNF production. J. Invest. Dermatol., 135: 851-860.
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  6. Raulf, N., R. El-Attar, D. Kulms, D. Lecis and D. Delia et al., 2014. Differential response of head and neck cancer cell lines to TRAIL or Smac mimetics is associated with the cellular levels and activity of caspase-8 and caspase-10. Br. J. Cancer, 111: 1955-1964.
    CrossRef  |  
  7. Konrath, F., J. Witt, T. Sauter and D. Kulms, 2014. Identification of new IκBα complexes by an iterative experimental and mathematical modeling approach. PLoS Comp. Biol., 10.1371/journal.pcbi.1003528.
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  8. Bullenkamp, J., N. Raulf, B. Ayaz, H. Walczak and D. Kulms et al., 2014. Bortezomib sensitises TRAIL-resistant HPV positive head and neck cancer cells to TRAIL through a caspase-dependent, E6-independent mechanism. Cell Death Dis., Vol. 5. 10.1038/cddis.2014.455.
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  9. Vorsmann, H., F. Grober, H. Walles, S. Beissert, H. Walczak and D. Kulms, 2013. Development of a human three-dimensional organotypic skin-melanoma spheroid model for in vitro drug testing. Cell Death Dis., Vol. 4. 10.1038/cddis.2013.249.
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  10. Strozyk, E. and D. Kulms, 2013. The role of AKT/mTOR pathway in stress response to UV- irradiation: implication in skin carcinogenesis by regulation of apoptosis, autophagy and senescence. Int. J. Mol. Sci., 14: 15260-15285.
    CrossRef  |  
  11. Niessner, H., A. Forschner, B. Klumpp, J.B. Honegger and M. Witte et al., 2013. Targeting hyperactivation of the AKT survival pathway to overcome therapy resistance of melanoma brain metastases. Cancer Med., 2: 76-85.
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  12. Beck, D., H. Niessner, K.S. Smalley, K. Flaherty and K.H. Paraiso et al., 2013. Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells. Sci. Signal., Vol. 6. 10.1126/scisignal.2003057.
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  13. Witt, J., F. Konrath, O. Sawodny, M. Ederer, D. Kulms and T. Sauter, 2012. Analysing the role of UVB-induced translational inhibition and PP2Ac deactivation in NF-κB signalling using a minimal mathematical model. PLoS One, Vol. 7. 10.1371/journal.pone.0040274.
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  14. Witt, J., S. Barisic, O. Sawodny, M. Ederer, D. Kulms and T. Sauter, 2011. Modelling time delay in the NFkappaB signaling pathway following low dose IL-1 stimulation. EURASIP J. Bioinform. Syst. Biol., 3: 1-6.
  15. Niessner, H., D. Beck, T. Sinnberg, K. Lasithiotakis and E. Maczey et al., 2011. The farnesyl transferase inhibitor lonafarnib inhibits mTOR signaling and enforces sorafenib-induced apoptosis in melanoma cells. J. Invest. Dermatol., 131: 468-479.
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  16. Hornle, M., N. Peters, B. Thayaparasingham, H. Vorsmann, H. Kashkar and D. Kulms, 2011. Caspase-3 cleaves XIAP in a positive feedback loop to sensitize melanoma cells to TRAIL-induced apoptosis. Oncogene, 30: 575-587.
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  17. Barisic, S., C. Schmidt, H. Walczak and D. Kulms, 2010. Tyrosine phosphatase inhibition triggers sustained canonical serine-dependent NFκB activation via Src-dependent blockade of PP2A. Biochem. Pharmacol., 80: 439-447.
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  18. Witt, J., S. Barisic, E. Schumann, F. Allgower, O. Sawodny, T. Sauter and D. Kulms, 2009. Mechanism of PP2A-mediated IKKβ dephosphorylation: A systems biological approach. BMC Syst. Biol., Vol. 3. 10.1186/1752-0509-3-71.
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  19. Thayaparasingham, B., A. Kunz, N. Peters and D. Kulms, 2009. Sensitization of melanoma cells to TRAIL by UVB-induced and NF-κB-mediated downregulation of xIAP. Oncogene, 28: 345-362.
  20. Sinnberg, T., K. Lasithiotakis, H. Niessner, B. Schittek and K.T. Flaherty et al., 2009. Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide. J. Invest. Dermatol., 129: 1500-1515.
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  21. Lasithiotakis, K.G., T.W. Sinnberg, B. Schittek, K.T. Flaherty and D. Kulms et al., 2008. Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death and abrogates invasive growth of melanoma cells. J. Invest. Dermatol., 128: 2013-2023.
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  22. Barisic, S., E. Strozyk, N. Peters, H. Walczak and D. Kulms, 2008. Identification of PP2A as a crucial regulator of the NF-kappaB feedback loop: its inhibition turns NF-kappaB into a pro-apoptotic factor. Cell Death Differ., 15: 1681-1690.
  23. Meier, F., S. Busch, K. Lasithiotakis, D. Kulms and C. Garbe et al., 2007. Combined targeting of MAPK and AKT signalling pathways is a promising strategy for melanoma treatment. Br. J. Dermatol., 156: 1204-1213.
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  24. Strozyk, E., J.P. Wysocki and D. Kulms, 2006. Combination therapy of skin cancer: Cytokines and apoptosis. Clin. Derm.: Retinoids Treatments, 8: 1-6.
  25. Strozyk, E., B. Poppelmann, T. Schwarz and D. Kulms, 2006. Differential effects of NFκB on apoptosis induced by DNA-damaging agents: The type of DNA damage determines the final outcome. Oncogene, 25: 6239-6251.
  26. Schwarz, T. and D. Kulms, 2006. NFKB and Cytokines. In: Interleukins, Litwack, G. (Ed.). Academic Press, San Diego, ISBN: 9780127098746, pp: 284-296.
  27. Poeppelmann, B., K. Klimmek, E. Strozyk, R. Voss, T. Schwarz and D. Kulms, 2005. NFκB-dependent downregulation of TRAF proteins contributes to IL-1-mediated enhancement of UVB-induced apoptosis. J. Biol. Chem., 280: 15635-15643.
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  28. Zeise, E., M. Weichenthal, T. Schwarz and D. Kulms, 2004. Resistance of human melanoma cells against the death ligand TRAIL is reversed by ultraviolet-B radiation via downregulation of FLIP. J. Invest. Dermatol., 123: 746-754.
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  29. Schwarz, A., S. Stander, M. Berneburg, M. Bohm and D. Kulms et al., 2002. Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair. Nat. Cell Biol., 4: 26-31.
  30. Kulms, D. and T. Schwarz, 2002. Ultraviolet Radiation and Apoptosis. In: UV-Induced Melanogenesis, Ortonne, J.P. (Ed.). Martin Dunitz Ltd., London, pp: 262-266.
  31. Kulms, D. and T. Schwarz, 2002. UV-induced signal transduction pathways. J. Dermatol., 29: 189-196.
  32. Kulms, D. and T. Schwarz, 2002. Molecular mechanisms involved in UV-induced apoptotic cell death. Skin Pharmacol. Physiol., 15: 342-347.
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  33. Kulms, D. and T. Schwarz, 2002. Independent contribution of three different pathways to ultraviolet-B-induced apoptosis. Biochem. Pharmacol., 64: 837-841.
  34. Kulms, D. and T. Schwarz, 2002. 20 years after-milestones in molecular photobiology. J. Invest. Dermatol. Symp. Proc., 7: 46-50.
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  35. Murphy, G., A.R. Young, H.C. Wulf, D. Kulms and T. Schwarz, 2001. The molecular determinants of sunburn cell formation. Exp. Dermatol., 10: 195-201.
  36. Kulms, D. and T. Schwarz, 2001. Ultraviolet radiation inhibits interleukin-2-induced tyrosine phosphorylation and the activation of STAT5 in T lymphocytes. J. Biol. Chem., 276: 12849-12855.
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  37. Kulms, D., B. Poppelmann and T. Schwarz, 2000. Ultraviolet radiation-induced interleukin 6 release in HeLa cells is mediated via membrane events in a DNA damage-independent way. J. Biol. Chem., 275: 15060-15066.
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  38. Kulms, D. and T. Schwarz, 2000. Molecular mechanisms of UV‐induced apoptosis. Photodermatol. Photoimmunol. Photomed., 16: 195-201.
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  39. Kulms, D., B. Poppelmann, D. Yarosh, T.A. Luger, J. Krutmann and T. Schwarz, 1999. Nuclear and cell membrane effects contribute independently to the induction of apoptosis in human cells exposed to UVB radiation. Proc. Natl. Acad. Sci., 96: 7974-7979.
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  40. Kothny-Wilkes, G., D. Kulms, T.A. Luger, M. Kubin and T. Schwarz, 1999. Interleukin-1 protects transformed keratinocytes from tumor necrosis factor-related apoptosis-inducing ligand-and CD95-induced apoptosis but not from ultraviolet radiation-induced apoptosis. J. Biol. Chem., 274: 28916-28921.
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  41. Kothny-Wilkes, G., D. Kulms, B. Poppelmann, T.A. Luger, M. Kubin and T. Schwarz, 1998. Interleukin-1 protects transformed keratinocytes from tumor necrosis factor-related apoptosis-inducing ligand. J. Biol. Chem., 273: 29247-29253.
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  42. Aragane, Y., D. Kulms, D. Metze, G. Wilkes, B. Poppelmann, T.A. Luger and T. Schwarz, 1998. Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand CD95L. J. Cell Biol., 140: 171-182.
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  43. Kulms, D., G. Schafer and U. Hahn, 1997. Overproduction of Sac7d and Sac7e reveals only Sac7e to be a DNA-binding protein with ribonuclease activity from the extremophilic archaeon Sulfolobus acidocaldarius. Biol. Chem., 378: 545-552.
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  44. Aragane, Y., D. Kulms, T.A. Luger and T. Schwarz, 1997. Down-regulation of interferon γ-activated STAT1 by UV light. Proc. Natl. Acad. Sci., 94: 11490-11495.
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  45. Kulms, D., G. Schafer and U. Hahn, 1995. SaRD, a new protein isolated from the extremophile archaeon Sulfolobus acidocaldarius, is a thermostable ribonuclease with DNA-binding properties. Biochem. Biophys. Res. Commun., 214: 646-652.
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