Hi, I am Ulrich Pfeffer, My LiveDNA is 49.6439
 
   
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Dr. Ulrich Pfeffer
 
Highest Degree: Ph.D. in Biochemistry and Molecular Biology from Free University Berlin, Germany
 
Institute: University of Genoa, Italy
 
Area of Interest: Molecular Sciences
  •   Carcinogenesis
  •   Cell Biochemistry
  •   Clinical and Experimental Metastasis
  •   Immunology
 
URL: http://livedna.org/49.6439
 
My SELECTED Publications
1:   Albini, A. and U. Pfeffer, 2006. A new tumor suppressor gene: Invasion, metastasis and angiogenesis as potential key targets. J. Natl. Cancer Inst., 98: 800-801.
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2:   Albini, A., C. Rosano, G. Angelini, A. Amaro, A. Esposito, D. Noonan and U. Pfeffer, 2013. Exogenous hormonal regulation in breast cancer cells by phytoestrogens and endocrine disruptors. Curr. Med. Chem. (In Press). .
3:   Albini, A., S. Indraccolo, D.M. Noonan and U. Pfeffer, 2010. Functional genomics of endothelial cells treated with anti-angiogenic or angiopreventive drugs. Clin. Exp. Metastasis., 27: 419-439.
CrossRef  |  PubMed  |  
4:   Albini, A., V. Mirisola and U. Pfeffer, 2008. Metastasis signatures: Genes regulating tumor-microenvironment interactions predict metastatic behavior. Cancer Metastasis Rev., 27: 75-83.
5:   Amaro, A., A. Esposito, A.M. Gallina, M. Nees, G. Angelini, A. Albini and U. Pfeffer, 2013. Validation of proposed prostate cancer biomarkers with gene expression data: A long road to travel. Cancer Metastasis Rev. (In Press). .
6:   Amaro, A., V. Mirisola, A. Esposito, A. Mehili and C. Rosano et al., 2013. Endocrine disruptor agent Nonyl phenol exerts an estrogen-like transcriptional activity on estrogen receptor positive breast cancer cells. Curr. Med. Chem. (In Press). .
7:   Amaro, A., V. Mirisola, G. Angelini, A. Musso and F. Tosetti et al., 2013. Evidence of epidermal growth factor receptor expression in uveal melanoma: inhibition of epidermal growth factor-mediated signalling by gefitinib and cetuximab triggered antibody-dependent cellular cytotoxicity. Eur. J. Cancer, 49: 3353-3365.
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8:   Anfosso, L., T. Efferth, A. Albini and U. Pfeffer, 2006. Microarray expression profiles of angiogenesis-related genes predict tumor cell response to artemisinins. Pharmacog. J., 6: 269-278.
PubMed  |  
9:   Bachetti, T., D. Di Paolo, S. Di Lascio, V. Mirisola and C. Brignole et al., 2010. PHOX2B-mediated regulation of ALK expression: In vitro identification of a functional relationship between two genes involved in neuroblastoma. PlosOne, Vol. 5. .
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10:   Bachmeier, B., I. Fichtner, P.H. Killian, E. Kronski, U. Pfeffer and T. Efferth, 2011. Development of resistance towards artesunate in MDA-MB-231 human breast cancer cells. PLoS One, Vol. 6. .
PubMed  |  
11:   Bachmeier, B.E., A.G. Nerlich, C.M. Iancu, M. Cilli, M. Jochum, A. Albini and U. Pfeffer, 2007. The chemopreventive polyphenol curcumin prevents hematogenous breast cancer metastases in immunodeficient mice through induction of apoptosis and inhibition of NFkB/AP-1/CRE dependent transcription of matrix metalloproteases. Cell. Physiol. Biochem., 19: 137-152.
12:   Bachmeier, B.E., A.G. Nerlich, V. Mirisola, M. Jochum and U. Pfeffer, 2008. Lineage infidelity and expression of melanocytic markers in human breast cancer. Int. J. Oncol., 33: 1011-1015.
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13:   Bachmeier, B.E., C.M. Iancu, P.H. Killian, E. Kronski and V. Mirisola et al., 2009. Overexpression of the ATP binding cassette gene ABCA1 determines resistance to Curcumin in M14 melanoma cells. Mol. Cancer, Vol. 8 10.1186/1476-4598-8-129.
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14:   Bachmeier, B.E., I.V. Mohrenz, V. Mirisola, E. Schleicher and F. Romeo et al., 2008. Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFkappaB. Carcinogenesis, 29: 779-789.
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15:   Bachmeier, B.E., P. Killian, U. Pfeffer and A.G. Nerlich, 2010. Novel aspects for the application of Curcumin in chemoprevention of various cancers. Front Biosci., 2: 697-717.
PubMed  |  
16:   Bachmeier, B.E., R. Vene, C.M. Iancu, U. Pfeffer and B. Mayer et al., 2005. Transcriptional control of cell density dependent regulation of matrix metalloproteinase and TIMP expression in breast cancer cell lines. Thromb. Haemos., 93: 761-769.
PubMed  |  
17:   Bachmeier, B.E., V. Mirisola, F. Romeo, L. Generoso and A. Esposito et al., 2010. Reference profile correlation reveals estrogen-like trancriptional activity of curcumin. Cell Physiol. Biochem., 26: 471-482.
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18:   Bisacchi, D., D.M. Noonan, S. Carlone, A. Albini and U. Pfeffer, 2002. Kaposi's sarcoma and human chorionic gonadotropin: Mechanisms, moieties and mysteries. Biol. Chem., 383: 1315-1320.
PubMed  |  
19:   Bosco, M.C., M. Puppo, C. Santangelo, L. Anfosso and U. Pfeffer et al., 2006. Hypoxia modifies the transcriptome of primary human monocytes: modulation of novel immune-related genes and identification of CC-chemokine ligand 20 as a new hypoxia-inducible gene. J. Immunol., 177: 1941-1955.
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20:   Caporali, S., E. Alvino, A. Esposito, M. Ciomei and M. Brasca et al., 2012. Down-regulation of the PTTG1 Proto-oncogene Is Involved in the melanoma suppressive effects of the cyclin-dependent kinase inhibitor PHA-848125. Biochem. Pharmacol., 84: 598-611.
PubMed  |  
21:   Caputo, A., E. Caci, L. Ferrera, N. Pedemonte and C. Barsanti et al., 2008. TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity. Science, 322: 590-594.
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22:   Castagnetta, L.A., M.D. Miceli, C.M. Sorci, U. Pfeffer and R. Farruggio et al., 1995. Growth of LNCaP human prostate cancer cells is stimulated by estradiol via its own receptor. Endocrinology, 136: 2309-2319.
PubMed  |  
23:   Catalano, M.G., U. Pfeffer, M. Raineri, P. Ferro and A. Curto et al., 2000. Altered expression of androgen-receptor isoforms in human colon-cancer tissues. Int. J. Cancer, 86: 325-330.
PubMed  |  
24:   Cavarra, E., P. Fardin, S. Fineschi, A. Ricciardi and G. De Cunto et al., 2009. Early response of gene clusters is associated with mouse lung resistance or sensitivity to cigarette smoke. Am. J. Physiol. Lung Cell. Mol. Physiol., 296: L418-L429.
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25:   Corradi, L., V. Mirisola, I. Porro, L. Torterolo, M. Fato, P. Romano and U. Pfeffer, 2009. Survival online: A web-based service for the analysis of correlations between gene expression and clinical and follow-up data. BMC Bioinform., Vol. 10 10.1186/1471-2105-10-S12-S10.
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26:   Dallaglio, K., A. Bruno, AR. Cantelmo, A.I. Esposito and L. Ruggiero et al., 2013. Paradoxic effects of metformin on endothelial cells and angiogenesis. Carcinogenesis (In Press). .
27:   Dell'Eva, R., U. Pfeffer, R. Vene, L. Anfosso, A. Forlani, A. Albini and T. Efferth, 2004. Inhibition of angiogenesis in vivo and growth of Kaposi's sarcoma xenograft tumors by the anti-malarial artesunate. Biochem. Pharmacol., 68: 2359-2366.
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28:   Dell'Eva, R., U. Pfeffer, S. Indraccolo, A. Albini and D. Noonan, 2002. Inhibition of tumor angiogenesis by angiostatin: From recombinant protein to gene therapy, Endothelium. J. Endothelial Cell Res., 9: 3-10.
PubMed  |  
29:   Dono, M., G. Angelini, M. Cecconi, A. Amaro and A.I. Esposito et al., 2013. Mutation frequencies of GNAQ, GNA11, BAP1, SF3B1, EIF1AX and TERT in uveal melanoma: Detection of an activating mutation in the TERT gene promoter in a single case of uveal melanoma. Brit. J. Cancer (In Press). .
30:   Ferrari, N., G. Vidali and U. Pfeffer, 1997. Use of quantitative polymerase chain reaction to study retinoid receptor expression. Methods Enzymol., 282: 48-64.
31:   Ferrari, N., M. Morini, U. Pfeffer, S. Minghelli, D.M. Noonan and A. Albini, 2003. Inhibition of Kaposi's sarcoma in vivo by fenretinide. Clin. Cancer Res., 9: 6020-6029.
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32:   Ferrari, N., U. Pfeffer, F. Tosetti, C. Brigati and G. Vidali, 1994. An improved RT-PCR protocol for the quantitation of human retinoic acid receptor RNA. Exp. Cell Res., 211: 121-126.
PubMed  |  
33:   Ferrari, N., U. Pfeffer, R. Dell'Eva, C. Ambrosini, D.M. Noonan and A. Albini, 2005. The transforming growth factor-β family members bone morphogenetic protein-2 and macrophage inhibitory cytokine-1 as mediators of the antiangiogenic activity of N-(4-Hydroxyphenyl) retinamide. Clin. Cancer Res., 11: 4610-4619.
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34:   Ferro, P., A. Forlani, M. Muselli and U. Pfeffer, 2003. Alternative splicing of the human estrogen receptor a primary transcript: Mechanisms of exon skipping. Int. J. Mol. Med., 12: 355-363.
35:   Ferro, P., M.G. Catalano, M. Raineri, G. Reato and R. dell'Eva et al., 2000. Somatic alterations of the androgen receptor CAG repeat in human colon cancer delineate a novel mutation pathway independent of microsatellite instability. Cancer Gen. Cytogenetics, 123: 35-40.
PubMed  |  
36:   Ferro, P., M.G. Catalano, R. Dell'Eva, N. Fortunati and U. Pfeffer, 2002. The androgen receptor CAG repeat: A modifier of carcinogenesis? Mol. Cell. Endocrinol., 193: 109-120.
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37:   Ferro, P., R. dell'Eva and U. Pfeffer, 2001. Are there CAG repeat expansion-related disorders outside the central nervous system? Brain Res. Bull., 56: 259-264.
PubMed  |  
38:   Florio, T., M. Morini, V. Villa, S. Arena and A. Corsaro et al., 2003. Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor-3-mediated regulation of endothelial nitric oxide synthase and mitogen-activated protein kinase activities. Endocrinology, 144: 1574-1584.
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39:   Gangemi, R., V. Mirisola, G. Barisione, M. Fabbi and A. Brizzolara et al., 2012. Mda-9/syntenin is expressed in uveal melanoma and correlates with metastatic progression. PLoS One, Vol. 7. .
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40:   Gennari, A., M.P. Sormani, P. Pronzato, M. Puntoni, M. Colozza, U. Pfeffer and P. Bruzzi, 2008. HER2 status and efficacy of adjuvant anthracyclines in early breast cancer: A pooled analysis of randomized trials. J. Natl. Cancer Inst., 100: 14-20.
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41:   Indraccolo, S., U. Pfeffer, S. Minuzzo, G. Esposito and V. Roni et al., 2007. Identification of genes selectively regulated by IFNs in endothelial cells. J. Immunol., 178: 1122-1135.
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42:   Izzotti, A., P. Larghero, C. Cartiglia, M. Longobardi, U. Pfeffer, V.E. Steele and S. De Flora, 2010. Modulation of microRNA expression by budesonide, phenethyl isothiocyanate and cigarette smoke in mouse liver and lung. Carcinogenesis, 31: 894-901.
PubMed  |  
43:   Izzotti, A., P. Larghero, R. Balansky, U. Pfeffer, V.E. Steele and S. De Flora, 2011. Interplay between histopathological alterations, cigarette smoke and chemopreventive agents in defining microRNA profiles in mouse lung. Mutat. Res., 717: 17-24.
PubMed  |  
44:   Killian, P., E. Kronski, K. Michalik, O. Barbieri and S. Astigiano et al., 2012. Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory Cytokines CXCL1 and -2. Carcinogenesis, 33: 2507-2519.
45:   Larghero, P., R. Vene, S. Minghelli, G. Travaini and M. Morini et al., 2007. Biological assays and genomic analysis reveal lipoic acid modulation of endothelial cell behavior and gene expression. Carcinogenesis, 28: 1008-1020.
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46:   Lorusso, G., R. Dell'Eva, R. Vene, U. Pfeffer and A. Albini, 2001. Rationale, problems and perspectives in anti-angiogenic therapy. Tumori, 87: S17-S19.
PubMed  |  
47:   Mangerini, R., F. Argellati, U. Pfeffer and F. Boccardo, 2012. Effects of bicalutamide and 4OH-tamoxifen on androgen-regulated gene expression in the LNCaP cell line. Anticancer Res., 32: 5323-5329.
PubMed  |  
48:   Marchisone, C., U. Pfeffer, F. Del Grosso, D.M. Noonan, L. Santi and A. Albini, 2000. Progress towards gene therapy for cancer. J. Exp. Clin. Cancer Res., 19: 261-270.
PubMed  |  
49:   Marini, C., B. Salani, M. Massollo, A. Amaro and A. Esposito et al., 2013. Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer. Cell Cycle. (In Press). .
50:   Massollo, M., C. Marini, M. Brignone, L. Emionite and B. Salani et al., 2013. Metformin temporal and localized effects on gut glucose metabolism assessed using 18F-FDG PET in mice. J. Nucl. Med., 54: 259-266.
PubMed  |  
51:   Mazibrada, J., M. De Andrea, M. Ritta, C. Borgogna and R. Dell'eva et al., 2010. In vivo growth inhibition of head and neck squamous cell carcinoma by the Interferon-inducible gene IFI16. Cancer Lett., 287: 33-43.
PubMed  |  
52:   Mirisola, V., A. Zuccarino, B.E. Bachmeier, M.P. Sormani, J. Falter, A. Nerlich and U. Pfeffer, 2009. CXCL12/SDF1 expression by breast cancers is an independent prognostic marker of disease-free and overall survival. Eur. J. Cancer, 45: 2579-2587.
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53:   Mirisola, V., R. Mora, A.I. Esposito, L. Guastini and F. Tabacchiera et al., 2011. A prognostic multigene classifier for squamous cell carcinomas of the larynx. Cancer Lett., 307: 37-46.
PubMed  |  
54:   Monticone, M., A. Bisio, A. Daga, P. Giannoni and W. Giaretti et al., 2010. Demethyl fruticulin A (SCO-1) causes apoptosis by inducing reactive oxygen species in mitochondria. J Cell. Biochem., 111: 1149-1159.
PubMed  |  
55:   Monticone, M., A. Daga, S. Candiani, F. Romeo and V. Mirisola et al., 2012. Identification of a novel set of genes reflecting different in vivo invasive patterns of human GBM cells. BMC Cancer, Vol. 12. .
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56:   Morini, M., L. Roccatagliata, R. Dell'Eva, E. Pedemonte and R. Furlan et al., 2004. α-lipoic acid is effective in prevention and treatment of experimental autoimmune encephalomyelitis. J. Neuroimmunol., 148: 146-153.
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57:   Noonan, D.M., N. Vannini, U. Pfeffer, G. Lorusso and A. Albini, 2008. Endothelial cell aging and apoptosis in prevention and disease: E-selectin expression and modulation as a model. Curr. Pharm. Design, 14: 221-225.
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58:   Pedemonte, N., E. Caci, E. Sondo, A. Caputo and K. Rhoden et al., 2007. Thiocyanate transport in resting and IL-4-stimulated human bronchial epithelial cells: Role of pendrin and anion channels. J. Immunol., 178: 5144-5153.
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59:   Persano, L., L. Moserle, G. Esposito, V. Bronte and V. Barbieri et al., 2009. Interferon-α counteracts the angiogenic switch and reduces tumor cell proliferation in a spontaneous model of prostatic cancer. Carcinogenesis, 30: 851-860.
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60:   Pfeffer, U., 1996. Estrogen receptor mRNA variants. Do they have a physiological role? Annals New York Acad. Sci., 784: 304-313.
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61:   Pfeffer, U., 1998. One-tube RT-PCR with sequence-specific primers. Meth. Mol. Biol., 86: 143-151.
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62:   Pfeffer, U., D. Bisacchi, M. Morini, R. Benelli and S. Minghelli et al., 2002. Human chorionic gonadotropin inhibits Kaposi's sarcoma associated angiogenesis, matrix metalloprotease activity and tumor growth. Endocrinology, 143: 3114-3121.
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63:   Pfeffer, U., D. Noonan and A. Albini, 2003. Re: Microarray studies challenge theories of metastasis. J. Natl. Cancer Inst., 95: 829-829.
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64:   Pfeffer, U., E. Fecarotta and G. Vidali, 1995. Coexpression of multiple estrogen receptor variant messenger RNAs in normal and neoplastic breast tissues and in MCF-7 cells. Cancer Res., 55: 2158-2165.
PubMed  |  
65:   Pfeffer, U., E. Fecarotta and G. Vidali, 1995. Efficient one-tube RT-PCR amplification of rare transcripts using short sequence-specific reverse transcription primers. Biotechniques, 18: 204-206.
PubMed  |  
66:   Pfeffer, U., E. Fecarotta, G. Arena, A. Forlani and G. Vidali, 1996. Alternative splicing of the estrogen receptor primary transcript normally occurs in estrogen receptor positive tissues and cell lines. J. Steroid Biochem. Mol. Biol., 56: 99-105.
PubMed  |  
67:   Pfeffer, U., F. Romeo, D.M. Noonan and A. Albini, 2009. Prediction of breast cancer metastasis by genomic profiling: Where do we stand? Clin. Exp. Metastasis, 26: 547-558.
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68:   Pfeffer, U., N. Ferrari, M. Morini, R. Benelli, D.M. Noonan and A. Albini, 2002. Antiangiogenic activity of chemopreventive drugs. Int. J. Biol. Markers, 18: 70-74.
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69:   Pfeffer, U., N. Ferrari, R. Dell'Eva, S. Indraccolo, M. Morini, D.M. Noonan and A. Albini, 2005. Molecular mechanisms of action of angiopreventive anti-oxidants on endothelial cells: Microarray gene expression analyses. Mutation Res., 591: 198-211.
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70:   Pfeffer, U., P. Ferro, V. Pavia, S. Trombino, R. Dell'Eva, G. Merlo and G. Levi, 2001. The coding region of the human DLX6 gene contains a polymorphic CAG/CCG repeat. Int. J. Oncol., 18: 1293-1297.
PubMed  |  
71:   Puzone, R., G. Savarino, S. Salvi, M. Dal Bello and G. Barletta et al., 2013. Glyceraldehyde-3-phosphate dehydrogenase gene over expression in poor prognosis non small cell lung cancer. Mol. Cancer, Vol. 12. (In Press). .
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72:   Salani, B., C. Marini, A. Del Rio, S. Ravera and M. Massollo et al., 2013. Direct inhibition of hexokinase i and ii activity underlies a new anticancer property of metformin. Sci. Report, Vol. 3. (In Press). .
73:   Sondo, E., V. Tomati, E. Caci, A.I. Esposito, U. Pfeffer, N. Pedemonte and L.J. Galietta, 2011. Rescue of the mutant CFTR chloride channel by pharmacological correctors and low temperature analyzed by gene expression profiling. Am. J. Physiol. Cell. Physiol., 301: C872-C885.
PubMed  |