Prof. Dr. Armando Rojas Rubio
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Prof. Dr. Armando Rojas Rubio

Professor and Head
Faculty of Medicine, Catholic University of Maule, Chile


Highest Degree
Ph.D. in Biology from National Center for Scientific Research, Cuba

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Area of Interest:

Biomedical Sciences
100%
Research Communications
62%
Vascular Pharmacology
90%
Microbes and Infection
75%
Tumor Biology
55%

Research Publications in Numbers

Books
4
Chapters
4
Articles
109
Abstracts
0

Selected Publications

  1. Rojas, A., F. Delgado-Lopez and I. Gonzalez, 2017. Tumor-associated macrophages in gastric cancer: More than bystanders in tumor microenvironment. Gastric Cancer, 20: 215-216.
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  2. Rojas, A., F. Delgado-Lopez, R. Perez-Castro, I. Gonzalez and J. Romero et al., 2016. HMGB1 enhances the protumoral activities of M2 macrophages by a RAGE-dependent mechanism. Tumor Biol., 37: 3321-3329.
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  3. Fuentes, E., I. Palomo and A. Rojas, 2016. Cross-talk between platelet and tumor microenvironment: Role of multiligand/RAGE axis in platelet activation. Blood Rev., 30: 213-221.
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  4. Uribarri, J., M.D. del Castillo, M.P. de la Maza, R. Filip and A. Gugliucci et al., 2015. Dietary AGEs and their role in health and disease. Adv. Nutr., 6: 461-473.
  5. Rojas, A., R. Perez-Castro, I. Gonzalez, F. Delgado, J. Romero and I. Rojas, 2014. The emerging role of the receptor for advanced glycation end products on innate immunity. Int. Rev. Immunol., 33: 67-80.
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  6. Fuentes, E., J. Caballero, M. Alarcon, A. Rojas and I. Palomo, 2014. Chlorogenic acid inhibits human platelet activation and thrombus formation. PLoS One, Vol. 9. 10.1371/journal.pone.0090699.
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  7. Rojas, A., F. Delgado-Lopez, I. Gonzalez, R. Perez-Castro, J. Romero and I. Rojas, 2013. The receptor for advanced glycation end-products: A complex signaling scenario for a promiscuous receptor. Cell. Signalling, 25: 609-614.
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  8. Gonzalez, D., A. Rojas, M.B. Herrera and R.S. Conlan, 2012. iNOS activation regulates β-catenin association with its partners in endothelial cells. PloS One, Vol. 7. 10.1371/journal.pone.0052964.
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  9. Rojas, A., I. Gonzalez, E. Morales, R. Perez-Castro, J. Romero and H. Figueroa, 2011. Diabetes and cancer: Looking at the multiligand/RAGE axis. World J. Diabetes, 2: 108-113.
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  10. Rojas, A., I. Gonzalez, B. Rodriguez, J. Romero and H. Figueroa et al., 2011. Evidence of involvement of the receptor for advanced glycation end-products (RAGE) in the adhesion of Helicobacter pylori to gastric epithelial cells. Microbes Infect., 13: 818-823.
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  11. Rojas, A., 2011. Cell line cross-contamination: Who wins? J. Biol. Chem., Vol. 286. .
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  12. Rojas, A., D. Gonzalez, H. Figueroa, M.A. Morales and J. Romero, 2010. Modulation of nitric oxide pathway by multiligands/RAGE axis: A crossing point on the road to microvascular complication in diabetes. Curr. Enzyme Inhibition, 6: 34-45.
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  13. Rojas, A., H. Figueroa and E. Morales, 2009. Fueling inflammation at tumor microenvironment: The role of multiligand/RAGE axis. Carcinogenesis, 31: 334-341.
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  14. Palomo, I., R. Moore-Carrasco, M. Alarcon, A. Rojas, F. Espana, V. Andres and H. Gonzalez-Navarro, 2009. Pathophysiology of the proatherothrombotic state in the metabolic syndrome. Frontiers Biosci., 2: 194-208.
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  15. Rojas, A., I. Gonzalez and H. Figueroa, 2008. Cell line cross‐contamination in biomedical research: A call to prevent unawareness. Acta Pharmacol. Sin., 29: 877-880.
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  16. Rojas, A., E. Mercadal, H. Figueroa and M.A. Morales, 2008. Advanced Glycation and ROS: A link between diabetes and heart failure. Curr. Vascular Pharmacol., 6: 44-51.
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  17. Palomo, I.G., F.M. Segovia, M.L. Alarcon, B.Y. Fuentes, J.G. Pereira, A. Rojas and R. Forastiero, 2007. An insight into the pathophysiology of thrombosis in antiphospholipid syndrome. Front. Biosci., 12: 3093-3103.
  18. Rojas, A., H. Figueroa, M.A. Morales and L. Re, 2006. Facing up the ROS labyrinth-where to go? Curr. Vascular Pharmacol., 4: 277-289.
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  19. Rojas, A., H. Figueroa, L. Re and M.A. Morales, 2006. Oxidative stress at the vascular wall. Mechanistic and pharmacological aspects. Arch. Med. Res., 37: 436-448.
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  20. Rojas, A. and M.A. Morales, 2004. Advanced glycation and endothelial functions: A link towards vascular complications in diabetes. Life Sci., 76: 715-730.
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  21. Gonzalez, D., B. Herrera, A. Beltran, K. Otero, G. Quintero and A. Rojas, 2003. Nitric oxide disrupts VE-cadherin complex in murine microvascular endothelial cells. Biochem. Biophys. Res. Commun., 304: 113-118.
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  22. Romay, C., R. Delgado, D. Remores, R. Gonzalez and A. Rojas, 2001. Phycocyanin extract reduces TNF-a and nitrite levels in serum of mice treated with endotoxin. Drug Res., 51: 733-736.
  23. Rodriguez, B.L., A. Rojas, J. Campos, T. Ledon, E. Valle, W. Toledo and R. Fando, 2001. Differential interleukin-8 response of intestinal epithelial cell line to reactogenic and nonreactogenic candidate vaccine strains of Vibrio cholerae. Infect. Immunity, 69: 613-616.
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  24. Otero, K., F. Martinez, A. Beltran, D. Gonzalez and B. Herrera et al., 2001. Albumin-derived advanced glycation end-products trigger the disruption of the vascular endothelial cadherin complex in cultured human and murine endothelial cells. Biochem. J., 359: 567-574.
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  25. Orive, G., R.M. Hernandez, A.R. Gascon, M. Igartua, A. Rojas and J.L. Pedraz, 2001. Microencapsulation of an anti‐VE-cadherin antibody secreting 1B5 hybridoma cells. Biotechnol. Bioeng., 76: 285-294.
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  26. Rojas, A., S. Romay, D. Gonzalez, B. Herrera, R. Delgado and K. Otero, 2000. Regulation of endothelial nitric oxide synthase expression by albumin-derived advanced glycosylation end products. Circ. Res., 86: e50-e54.
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  27. Rodriguez, B.L., A. Rojas and J.A. Benitez, 1998. Cholera toxin differentially regulates nitric oxide synthesis, tumor necrosis factor-α production and respiratory burst in murine macrophages. FEMS Immunol. Med. Microbiol., 22: 193-198.
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  28. Lopez, E., S. Hortelano, A. Rojas and L. Bosca, 1998. Triggering of peritoneal macrophages with interferon a/β attenuates the expression of inducible nitric oxide synthase through a decrease in NF-kB activation. J. Immunol., 160: 2889-2895.
  29. Rojas, A., L. Caveda, C. Romay, E. Lopez and S. Valdes et al., 1996. Effect of advanced glycosylation end products on the induction of nitric oxide synthase in murine macrophages. Biochem. Biophys. Res. Commun., 225: 358-362.
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  30. Padron, J., L. Glaria, O. Martinez, M. Torres and E. Lopez etal., 1996. Nitric oxide modulates interleukin-2-induced proliferation in CTLL-2 cells. Mediators Inflammation, 5: 324-327.
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  31. Delgado, R., A. Rojas, L.A. Glaria, M. Torres and F. Duarte et al., 1995. Ca(2+)-independent nitric oxide synthase activity in human lung after cardiopulmonary bypass. Thorax, 50: 403-404.
  32. Sozzani, S., D.E. Agwu, M.D. Ellenburg, M. Locati and M. Rieppi et al., 1994. Activation of phospholipase D by interleukin-8 in human neutrophils. Blood, 84: 3895-3901.
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  33. Rojas, A., R. Delgado, L. Glaria and M. Palacios, 1993. Monocyte chemotactic protein-1 inhibits the induction of nitric oxide synthase in J774 cells. Biochem. Biophys. Res. Commun., 196: 274-279.
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  34. Rojas, A., J. Padron, L. Caveda, M. Palacios and S. Moncada, 1993. Role of nitric oxide pathway in the protection against lethal endotoxemia afforded by low doses of lipopolysaccharide. Biochem. Biophys. Res. Commun., 191: 441-446.
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  35. Palacios, M., J. Padron, L. Glaria, A. Rojas, R. Delgado, R. Knowles and S. Moncada, 1993. Chlorpromazine inhibits both the constitutive nitric oxide synthase and the induction of nitric oxide synthase after LPS challenge. Biochem. Biophys. Res. Commun., 196: 280-286.
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  36. Rojas, A., M. Zayas, G. Falero and I. Rodriguez, 1992. Competitive enzyme inhibition immunoassay of apolipoprotein B based on monoclonal antibody. Clin. Chim. Acta, 205: 245-247.
  37. Rojas, A., 1992. No increase in chromosome aberrations in lymphocytes from workers exposed to nitrogen fertilisers. Mutation Res. Lett., 281: 133-135.
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  38. Rojas, A. and S. Fernandez, 1992. No increase in chromosome aberrations in workers from an oil catalytic cracking plant. Mutation Res. Lett., 282: 209-212.
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  39. Falero, G., A. Otero, J. Sarracent, B. Rodriguez, A. Rojas and I. Rodriguez, 1992. Generation of bispecific monoclonal antibodies recognizing ad-and ay-subtypes of HbsAg. Hybridoma, 11: 441-449.