Hi, I am Aldo Domingo Mottino, My LiveDNA is 54.6051
 
   
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Dr. Aldo Domingo Mottino
 
Highest Degree: Ph.D. in Biochemistry from National University of Rosario, Argentina
 
Institute: Universidad Nacional de Rosario, Argentina
 
Area of Interest: Pharmacology and Toxicology
  •   Biochemical Pharmacology
  •   Physiology
  •   Life Sciences
  •   Experimental Therapeutics
 
URL: http://livedna.org/54.6051
 
My SELECTED Publications
1:   Arias, A., S.S. Villanueva, M.L. Ruiz, M.G. Luquita and L.M. Veggi et al., 2009. Regulation of expression and activity of rat intestinal Mrp2 by cholestatic estrogens. Drug Metab. Dispos., 37: 1277-1285.
PubMed  |  
2:   Arriaga, S.M., A.D. Mottino and A.M. Almara, 1999. Inhibitory effect of bilirubin on complement-mediated hemolysis. Biochim. Biophys. Acta, 1473: 329-336.
3:   Arriaga, S.M., A.M. Almara and A.D. Mottino, 2002. In vivo anticomplementary effect of bilirubin-IX alpha. Biochem. Pharmacol., 64: 741-744.
4:   Arriaga, S.M., C.L. Basiglio, A.D. Mottino and A.M. Almara, 2009. Unconjugated bilirubin inhibits C1 esterase activity. Clin. Biochem., 42: 919-921.
PubMed  |  
5:   Basiglio, C.L., A.D. Mottino and M.G. Roma, 2010. Tauroursodeoxycholate counteracts hepatocellular lysis induced by tensioactive bile salts by preventing plasma membrane-micelle transition. Chem. Biol. Interact., 188: 386-392.
PubMed  |  
6:   Basiglio, C.L., P.E.J. Sanchez, A.D. Mottino and M.G. Roma, 2009. Differential effects of silymarin and its active component silibinin on plasma membrane stability and hepatocellular lysis. Chem. Biol. Interact., 179: 297-303.
PubMed  |  
7:   Basiglio, C.L., S.M. Arriaga, F. Pelusa, A.M. Almara, J. Kapitulnik and A.D. Mottino, 2010. Complement activation and disease: Protective effects of hyperbilirubinemia. Clin. Sci. Rev., 118: 99-113.
PubMed  |  
8:   Basiglio, C.L., SM. Arriaga, H.F. Pelusa, A.M. Almara, MG. Roma and AD. Mottino, 2007. Protective role of unconjugated bilirubin on complement-mediated hepatocytolysis. Biochim. Biophys. Acta, 1770: 1003-1010.
PubMed  |  
9:   Boaglio, A., A. Zucchetti, P.E.J. Sanchez, J. Pellegrino and J. Ochoa et al., 2010. PI3K/AKT signaling pathway is involved in estradiol 17β-D-glucuronide-induced cholestasis: Complementarity with PKC alpha. Hepatology, 62: 1465-1476.
10:   Catania, V.A., M.G. Luquita, E.J. Sanchez Pozzi, A.M. Ferri and A.D. Mottino, 1992. Absence of hepatic p-nitrophenol UDP-glucuronosyltransferase induction by spironolactone in male rats: Possible involvement of testosterone. Can. J. Physiol. Pharmacol., 70: 1502-1507.
PubMed  |  
11:   Catania, V.A., M.G. Luquita, E.J. Sanchez Pozzi, S. Ikushiro, Y. Emi, T. Iyanagi and A.D. Mottino, 2003. Effect of spironolactone on the expresion of rat hepatic UDP-glucuronosyltransferase. Biochem. Pharmacol., 66: 171-177.
PubMed  |  
12:   Catania, V.A., M.G. Luquita, M.C. Carrillo and A.D. Mottino, 1990. Sex differences in spironolactone induction of rat intestinal and hepatic p-nitrophenol UDPglucuronyltransferase. Can. J. Physiol. Pharmacol., 68: 1385-1387.
PubMed  |  
13:   Catania, V.A., M.G. Luquita, P.E.J. Sanchez and A.D. Mottino, 2000. Quantitative and qualitative gender-related differences in jejunal glutathione S-transferase in the rat: Effect of testosterone administration. Life Sci., 84: 467-474.
PubMed  |  
14:   Catania, V.A., P.E.J. Sanchez, M.G. Luquita, M.L. Ruiz, S.M.S. Villanueva, B. Jones and A.D. Mottino, 2004. Co-regulation of expression of phase II metabolizing enzymes and multidrug resistanceassociated protein 2. Ann. Hepatol., 3: 11-17.
PubMed  |  
15:   Crocenzi, F.A., A.D. Mottino and M.G. Roma, 2004. Regulation of synthesis and trafficking of canalicular transporters and its alteration in acquired hepatocellular cholestasis. Curr. Med. Chem., 11: 1241-1253.
PubMed  |  
16:   Crocenzi, F.A., A.D. Mottino, E.J. Sanchez Pozzi, J.M. Pellegrino and E.A. Rodriguez Garay et al., 2003. Impaired localisation and transport function of canalicular bsep in taurolithocholate-induced cholestasis in the rat. Gut, 52: 1170-1177.
PubMed  |  
17:   Crocenzi, F.A., A.D. Mottino, J. Cao, L.M. Veggi and E.J. Sanchez Pozzi et al., 2003. Estradiol-17-D-glucuronide induces endocytic internalization of Bsep in the rat. Am. J. Physiol., 285: G449-G459.
PubMed  |  
18:   Crocenzi, F.A., A.E. Zucchetti, A.C. Boaglio, I.R. Barosso, P.E.J. Sanchez, A.D. Mottino and R.M.G. Front, 2012. Localization status of hepatocellular transporters in cholestasis. Bioscience, 17: 1201-1218.
PubMed  |  
19:   Crocenzi, F.A., E.J. Sanchez Pozzi, J.M. Pellegrino, E.A. Rodriguez Garay, A.D. Mottino and M.G. Roma, 2003. Preventive effect of silymarin against taurolithocholate-induced cholestasis in the rat. Biochem. Pharmacol., 66: 355-364.
PubMed  |  
20:   Crocenzi, F.A., J.M. Pellegrino, P.E.J. Sanchez, A.D. Mottino, E.A. Rodriguez Garay and M.G. Roma, 2000. Effect of silymarin on biliary bile salt secretion in the rat. Roma. Biochem. Pharmacol., 59: 1015-1022.
PubMed  |  
21:   Crocenzi, F.A., J.M. Pellegrino, V.A. Catania, M.G. Luquita, M.G. Roma, A.D. Mottino and E. Sanchez Pozzi, 2006. Galactosamine prevents ethinylestradiol-induced cholestasis. Drug Metab. Dispos., 34: 993-997.
PubMed  |  
22:   Crocenzi, F.A., P.E.J. Sanchez, J.M. Pellegrino, C.O. Favre and E.A. Rodriguez Garay et al., 2001. Beneficial effects of silymarin on estrogen induced cholestasis in the rat. Hepatology, 34: 329-339.
PubMed  |  
23:   Crocenzi, F.A., P.E.J. Sanchez, M.L. Ruiz, A.E. Zucchetti, M.G. Roma, A.D. Mottino and M. Vore, 2008. Ca2+-dependent protein kinase C isoforms are critical to estradiol 17β-D-glucuronide-induced cholestasis in the rat. Hepatology, 48: 1885-1895.
PubMed  |  
24:   Crocenzi, F.A., V. D'Andrea, V.A. Catania, M.G. Luquita and J.M. Pellegrino et al., 2005. Prevention of Mrp2 activity impairment in ethinylestradiol-induced cholestasis by ursodeoxycholate in the rat. Drug. Metab. Dispos., 33: 888-891.
PubMed  |  
25:   Ghanem, C.I., A. Arias, A. Novak, G.D. Carpini and S. Villanueva et al., 2011. Acetaminophen-induced stimulation of MDR1 expression and activity in rat intestine and in LS 174T human intestinal cell line. Biochem. Pharmacol., 81: 244-250.
PubMed  |  
26:   Ghanem, C.I., M.L. Ruiz, S.S.M. Villanueva, M. Luquita and S. Llesuy et al., 2009. Effect of repeated administration with subtoxic doses of acetaminophen to rats on enterohepatic recirculation of a subsequent toxic dose. Biochem. Pharmacol., 77: 1621-1628.
PubMed  |  
27:   Ghanem, C.I., M.L. Ruiz, S.S.M. Villanueva, M.G. Luquita and V.A. Catania et al., 2005. Shift from biliary to urinary elimination of acetaminophen glucuronide in acetaminophen pretreated rats. J. Pharmacol. Exp. Ther., 315: 987-995.
PubMed  |  
28:   Ghanem, C.I., P.C. Gomez, M.C. Arana, M. Perassolo and G. Delli Carpini et al., 2006. Induction of rat intestinal p-glycoprotein by spironolactone and its effect on absorption of orally administered digoxin. J. Pharmacol. Exp. Ther., 318: 1146-1152.
PubMed  |  
29:   Ghanem, C.I., P.C. Gomez, M.C. Arana, M. Perassolo and M.L. Ruiz et al., 2004. Effect of acetaminophen on expression and activity of rat liver multidrug resistanceassociated protein 2 and P-glycoprotein. Biochem. Pharmacol., 68: 791-798.
PubMed  |  
30:   Luquita, M.G., E.J. Sanchez Pozzi, V.A. Catania and A.D. Mottino, 1994. Analysis of p-nitrophenol glucuronidation in hepatic microsomes from lactating rats. Biochem. Pharmacol., 47: 1179-1185.
PubMed  |  
31:   Luquita, M.G., V.A. Catania, E.J. Pozzi, L.M. Veggi and T. Hoffman et al., 2001. Molecular basis of perinatal changes in UDP-glucuronosyltransferase activity in maternal rat liver. J. Pharmacol. Exp. Ther., 298: 49-56.
PubMed  |  
32:   Morisoli, L.S., A.D. Mottino, J.M. Pellegrino, E.E. Guibert and E.A. Rodriguez Garay, 1982. Effect of Spironolactone on Bilirubin metabolism in rat liver and small intestinal mucosa. Biochem. Pharmacol. 31: 1469-1474.
PubMed  |  
33:   Mottino, A.D. and E.A. Rodriguez Garay, 1987. Influence of uridine diphosphoglucuronic acid on Bilirubin glucuronidation in liver microsomes from normal and Spironolactone treated rats. Acta Physiol. Pharmacol. Latinoam., 37: 479-484.
PubMed  |  
34:   Mottino, A.D. and V.A. Catania 2008. Hepatic drug transporters and nuclear receptors: Regulation by therapeutic agents. World J. Gastroenterol., 14: 7068-7074.
PubMed  |  
35:   Mottino, A.D., B. Tuchwever, G.L. Plaa and I. Yousef, 2000. Role of periportal and perivenous hepatocytes in taurolitocholic-induced cholestasis in the rat. Toxicol. Lett., 116: 69-77.
36:   Mottino, A.D., E.E. Guibert and E.A. Rodriguez Garay, 1989. Additive effect of combined Spironolactone and Phenobarbital treatment on hepatic bilirubin UDP-Glucuronyltransferase. Biochem. Pharmacol., 38: 851-853.
PubMed  |  
37:   Mottino, A.D., E.E. Guibert and E.A. Rodriguez Garay, 1991. Effect of spironolactone and phenobarbital administration on bilirubin glucuronidation in hepatic and extrahepatic rat microsomes. Biochem. Pharmacol., 41: 1075-1077.
PubMed  |  
38:   Mottino, A.D., E.E. Guibert, C.E. Carnovale, L.S. Morisoli and E.A. Rodriguez Garay, 1983. Formation of Bilirubin monoglucuronide and diglucuronide in isolated rat hepatocytes, effect of Spironolactone. Biochem. Pharmacol., 32: 3157-3161.
PubMed  |  
39:   Mottino, A.D., F.A. Crocenzi, P.E.J. Sanchez, L.M. Veggi, M.G. Roma, M. Vore, 2005. Role of microtubules in estradiol-17-glucuronide-induced alteration of canalicular Mrp2 localization and activity. Am. J. Physiol., 288: G327-G336.
PubMed  |  
40:   Mottino, A.D., F.I. Carreras, S.A. Gradilone, R.A. Marinelli and M. Vore, 2006. Canalicular membrane localization of hepatocyte aquaporin-8 is preserved in estradiol-17β-D-glucuronide-induced cholestasis. J. Hepatol., 44: 232-233.
PubMed  |  
41:   Mottino, A.D., J. Cao, L.M. Veggi, F. Crocenzi, M.G. Roma and M. Vore, 2002. Altered localization and activity of canalicular MRP2 in estradiol-17β-D-glucuronideinduced. Hepatology, 35: 1409-1419.
PubMed  |  
42:   Mottino, A.D., J.A. Rassero and E.A. Rodriguez Garay, 1979. Effect of Spironolactone on Bilirubin conjugation by the rat liver. Biochem. Pharmacol., 28: 2215-2217.
43:   Mottino, A.D., J.M. Pellegrino, E.E. Guibert, M.G. Roma and E.A. Rodriguez Garay, 1988. Comparison of hepatic, renal and intestinal bilirubin UDP-Glucuronyltransferase activities in rat microsomes. Int. J. Biochem., 20: 1113-1116.
PubMed  |  
44:   Mottino, A.D., L.M. Veggi, M. Wood, J.V. Roman and M. Vore, 2003. Biliary secretion of glutathione in estradiol-17β-D-glucuronide-induced cholestasis. J. Pharmacol. Exp. Ther., 307: 306-313.
PubMed  |  
45:   Mottino, A.D., O. Denoya and E.A. Rodriguez Garay, 1985. Exogenous uridine diphosphoglucuronic acid breakdown in rat small intestinal mucosa preparations, effect of other nucleotides. Res. Commun. Chem. Pathol. Pharmacol., 49: 455-458.
PubMed  |  
46:   Mottino, A.D., T. Hoffman, F.A. Crocenzi, E.J. Sanchez Pozzi, M.G. Roma and M. Vore, 2007. Disruption of function and localization of tight-junctional structures and Mrp2 in sustained estradiol-17β-D-glucuronide-induced cholestasis. Am. J. Physiol. Gastrointest Liver Physiol., 293: G391-G402.
PubMed  |  
47:   Mottino, A.D., T. Hoffman, L. Jennes and M. Vore, 2000. Expression and localization of the multidrug resistance protein MRP2 in rat small intestine. J. Pharmacol. Exp. Ther., 293: 717-723.
PubMed  |  
48:   Mottino, A.D., T. Hoffman, L. Jennes, J. Cao and M. Vore, 2001. Expression of multidrug resistant protein Mrp2 in small intestine from pregnant and postpartum rats. Am. J. Physiol., 280: G1261-G1273.
PubMed  |  
49:   Mottino, A.D., T. Hoffman, P. Dawson, M.G. Luquita and J.A. Monti et al., 2002. Increased expression of the ileal apical sodium-dependent bile acid transporter (ASBT) in postpartum rats. Am. J. Physiol., 282: G51-G60.
PubMed  |  
50:   Novak, A., G.D. Carpini, M.L. Ruiz, M.G. Luquita, M.C. Rubio, A.D. Mottino and C.I. Ghanem, 2013. Acetaminophen inhibits intestinal p-glycoprotein transport activity. J. Pharm. Sci., 102: 3830-3837.
PubMed  |  
51:   Pellegrino, J.M., A.D. Mottino, J.V. Rodriguez and E.A. Rodriguez Garay, 1982. Biliary excretion of sulfobromophthalein in isolated perfused livers from normal and spironolactone-treated rats. Experientia, 38: 112-114.
Direct Link  |  
52:   Pellegrino, J.M., M.G. Roma, A.D. Mottino and E.A. Rodriguez Garay, 1991. Hepatic handling of photoirradiated bilirubin. A study in isolated perfused Wistar rat liver. Biochim. Biophys. Acta, 1074: 25-30.
PubMed  |  
53:   Rigalli, J.P., M.L. Ruiz, V.G. Perdomo, S.S. Villanueva, A.D. Mottino and V.A. Catania, 2011. Pregnane X receptor mediates the induction of P-glycoprotein by spironolactone in HepG2 cells. Toxicology, 285: 18-24.
PubMed  |  
54:   Roma, M.G., F.A. Crocenzi and A.D. Mottino, 2008. Dynamic localization of hepatocellular transporters: Molecular bases and regulatory aspects in health and disease. World J. Gastroenterol., 14: 6786-6801.
Direct Link  |  
55:   Ruiz, M.L., A.D. Mottino, V.A. Catania and M. Vore, 2013. Hormonal regulation of hepatic biotransformation and transport systems. Comprehens. Physiol., 3: 1721-1740.
PubMed  |  
56:   Ruiz, M.L., A.D. Mottino, V.A. Catania and M. Vore, 2013. Hormonal regulation of hepatic biotransformation and transport systems. Comprehens. Physiol., 3: 1721-1740.
PubMed  |  
57:   Ruiz, M.L., J.P. Rigalli, A. Arias, S.S. Villanueva and C. Banchio et al., 2013. Estrogen receptor-α mediates human multidrug resistance associated protein 3 induction by 17α-ethynylestradiol. Role of activator protein-1. Biochem. Pharmacol., 86: 401-409.
PubMed  |  
58:   Ruiz, M.L., S.S. Villanueva, M.G. Luquita, J.M. Pellegrino and J.P. Rigalli et al., 2009. Induction of intestinal multidrug resistance-associated protein 2 (Mrp2) by spironolactone in rats. Eur. J. Pharmacol., 623: 103-106.
PubMed  |  
59:   Ruiz, M.L., S.S. Villanueva, M.G. Luquita, S.I. Ikushiro, A.D. Mottino and V.A. Catania, 2007. Beneficial effect of spironolactone administration on ethynylestradiol-induced cholestasis in the rat: Involvement of up-regulation of multidrug resistance-associated protein 2. Drug Metab. Dispos., 35: 2060-2066.
PubMed  |  
60:   Ruiz, M.L., S.S.M. Villanueva, M.G. Luquita, M. Vore, A.D. Mottino and V.A. Catania, 2006. Ethynylestradiol increases expression and activity of rat liver Mrp3. Drug Metab. Dispos., 34: 1030-1034.
PubMed  |  
61:   Ruiz, M.L., S.S.M. Villanueva, M.G. Luquita, P.E.J. Sanchez and F.A. Crocenzi et al., 2005. Mechanisms involved in spironolactone-induced choleresis in the rat. Role of multidrug resistance-associated protein 2. Biochem. Pharmacol., 69: 531-539.
PubMed  |  
62:   Sanchez Pozzi, E.J., E.A. Rodriguez Garay and A.D. Mottino, 1992. Analysis of the interaction uridin 5'-diphosphoglucuronic acid with intestinal bilirubin UDP-glucuronyltransferase. Int. J. Biochem., 24: 1429-1434.
PubMed  |  
63:   Sanchez, P.E.J., A.D. Mottino, A. Sisti and M.G. Roma, 1995. Differential effect of ursodeoxycholate and its taurine conjugate on biliary transport maximum of bilirubin in the rat. Life Sci., 57: 973-981.
PubMed  |  
64:   Sanchez, P.E.J., F.A. Crocenzi, J.M. Pellegrino, V.A. Catania and M.G. Luquita et al., 2003. Ursodeoxycholate reduces ethinylestradiol glucuronidation in the rat: role in prevention of estrogen-induced cholestasis. J. Pharmacol. Exp. Ther., 306: 279-286.
PubMed  |  
65:   Sanchez, P.E.J., M.G. Luquita, V.A. Catania, E.A. Rodriguez Garay and A.D. Mottino, 1994. Inhibition of hepatic bilirubin UDP-glucuronosyltransferase by ursodeoxycholica acid. Life Sci., 55: 111-120.
PubMed  |  
66:   Sanchez, P.E.J., V.A. Catania, M.G. Luquita, M.G. Roma, E.A. Rodriguez Garay and A.D. Mottino, 1994. Effect of oral administration of ursodeoxycholic acid on hepatic and intestinal UDP-glucuronosyltransferase. Can. J. Physiol. Pharmacol., 72: 1265-1271.
PubMed  |  
67:   Veggi, L.M., F.A. Crocenzi, M.G. Roma and A.D. Mottino, 2005. Dapsone impairs the bile salt-independent fraction of bile flow in rats: possible involvement of its N-hydroxylated metabolite. Toxicology, 211: 97-106.
PubMed  |  
68:   Veggi, L.M., F.A. Crocenzi, M.G. Roma, P.A. Dawson and J.M. Pellegrino et al., 2002. Dapsone-induced cholestasis and impairment of bile salt output in the rat. Biochem. Pharmacol., 63: 1553-1563.
Direct Link  |  
69:   Veggi, L.M., L. Pretto, J.E. Ochoa, V.A. Catania and M.G. Luquita et al., 2008. Dapsone induces oxidative stress and impairs antioxidant defences in rat liver. Life Sci., 83: 155-163.
PubMed  |  
70:   Villanueva, S.S., A. Arias, M.L. Ruiz, J.P. Rigalli and J.M. Pellegrino et al., 2010. Induction of intestinal multidrug resistance-associated protein 2 by glucagon-like peptide-2 in the rat. J. Pharmacol. Exp. Ther., 335: 332-341.
PubMed  |  
71:   Villanueva, S.S., M.L. Ruiz, C.I. Ghanem, M.G. Luquita, V.A. Catania and A.D. Mottino, 2008. Hepatic synthesis and urinary elimination of acetaminophen glucuronide areexacerbated in bile duct-ligated rats. Drug Metab Dispos., 36: 475-480.
PubMed  |  
72:   Villanueva, S.S., V.G. Perdomo, M.L. Ruiz, J.P. Rigalli and A. Arias et al., 2012. Effect of Glucagon-like Peptide 2 on hepatic, renal and intestinal disposition of 1-chloro-2,4-dinitrobenzene. Drug Metab. Dispos., 40: 1252-1258.
PubMed  |  
73:   Villanueva, S.S.M., M.L. Ruiz, C.J. Soroka, S.Y. Cai and M.G. Luquita et al., 2006. Hepatic and extrahepatic synthesis and disposition of dinitrophenyl-S-glutathion in bile ductligated rats. Drug Metab. Dispos., 34: 1301-1309.
Direct Link  |  
74:   Villanueva, S.S.M., M.L. Ruiz, M.G. Luquita, P.E.J. Sanchez, V.A. Catania and A.D. Mottino, 2005. Involvement of Mrp2 in hepatic and intestinal disposition of dinitrophenyl-s-glutathione in partially hepatectomized rats. Tox. Sci., 84: 4-11.