Dr. Hugo Ruben Arias

Dr. Hugo Ruben Arias

Professor
California Northstate University College of Medicine, USA


Highest Degree
Ph.D. in Biochemistry from Universidad Nacional del Sur, Argentina

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Area of Interest:

Chemistry
100%
Neurochemistry
62%
Biochemistry
90%
Biophysics
75%
Molecular Biology
55%

Education

1990

Ph.D.

Universidad Nacional del Sur, Argentina

Biochemistry

Selected Publications

  1. Taylor, D.H., P.N. Burman, D.M. Hansen, R.S. Wilcox and B.R. Larsen et al., 2013. Nicotine enhances the excitability of gaba neurons in the ventral tegmental area via activation of alpha 7 nicotinic receptors on glutamate terminals. Biochem. Pharmacol., .

  2. Targowska-Duda, K.M., K. Jozwiak and H.R. Arias, 2013. Role of the nicotinic receptor β4 subunit in the antidepressant activity of novel N, 6-dimethyltricyclo [5.2. 1.0 2, 6] decan-2-amine enantiomers. Neurosci. Lett., 553: 186-190.
    CrossRef  |  

  3. Targowska-Duda, K.M., H.R. Arias and K. Jozwiak, 2013. Application of in silico methods to support experimental data: Interactions of antidepressants with nicotinic acetylcholine receptors. Open Conf. Proc. J., 4: 11-22.
    Direct Link  |  

  4. Radhakrishnan, R., A. Santamaria, L. Escobar and H.R. Arias, 2013. The β4 nicotinic receptor subunit modulates the chronic antidepressant effect mediated by bupropion. Neurosci. Lett., 555: 68-72.
    CrossRef  |  

  5. Perez, E.G., C. Ocampo, D. Feuerbach, J. Lopez, R. Tapia and H.R. Arias, 2013. Novel 1-(1-benzyl-1H-indol-3-yl)-N, N, N-trimethylmethanaminium iodides are competitive antagonists of the human α4β2 and α7 nicotinic acetylcholine receptors. Med. Chem. Commun., 4: 1166-1170.

  6. Arias, H.R., N.B. Fedorov, L.C. Benson, P.M. Lippiello, G.J. Gatto, D. Feuerbach and M.O. Ortells, 2013. Functional and structural interaction of (-)-reboxetine with the human α4β2 nicotinic acetylcholine receptor. J. Pharmacol. Exp. Ther., 344: 113-123.
    CrossRef  |  

  7. Arias, H.R., M.O. Ortells and D. Feuerbach, 2013. (-)-Reboxetine inhibits muscle nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites. Neurochem. Int., 63: 423-431.
    CrossRef  |  

  8. Arias, H.R., M.J. De Rosa, I. Berge, D. Feuerbach and C. Bouzat, 2013. Differential pharmacological activity of JN403 between α7 and muscle nicotinic acetylcholine receptors. Biochemistry, 52: 8480-8488.
    CrossRef  |  

  9. Arias, H.R., J.J. Lopez, D. Feuerbach, A. Fierro, M.O. Ortells and E.G. Perez, 2013. Novel 2-(substituted benzyl) quinuclidines inhibit human α7 and α4β2 nicotinic receptors by different mechanisms. Int. J. Biochem. Cell Biol., 45: 2420-2430.
    CrossRef  |  

  10. Arias, H.R., D. Feuerbach, K.M. Targowska-Duda, S. Aggarwal, D.J. Lapinsky and K. Jozwiak, 2012. Structural and functional interaction of (±)-2-(N-tert-butylamino)-3'-iodo-4'-azidopropiophenone, a photoreactive bupropion derivative, with nicotinic acetylcholine receptors. Neurochem. Int., 61: 1433-1441.
    CrossRef  |  

  11. Arias, H.R., 2012. Molecular interactions between ligands and nicotinic acetylcholine receptors revealed by studies with acetylcholine binding proteins. J. Thermodyn. Cat., Vol. 3. .
    Direct Link  |  

  12. Arias, H.R., R.X. Gu, D. Feuerbach, B.B. Gu, Y. Ye and D.Q. Wei, 2011. Novel positive allosteric modulators of the human α7 nicotinic acetylcholine receptor. Biochemistry, 5: 5263-5278.
    PubMed  |  

  13. Arias, H.R., D. Feuerbach, K.M. Targowska-Duda and K. Jozwiak, 2011. Structure-activity relationship of ibogaine analogs interacting with nicotinic acetylcholine receptors in different conformational states. Int. J. Biochem. Cell Biol., 43: 1330-1339.
    CrossRef  |  

  14. Santamaria, A., and H.R. Arias, 2010. Neurochemical and behavioral effects elicited by bupropion and diethylpropion in rats. Behav. Brain Res., 211: 132-139.
    CrossRef  |  Direct Link  |  

  15. Ortells, M.O. and H.R. Arias, 2010. Neuronal networks of nicotine addiction. Int. J. Biochem. Cell Biol., 42: 1931-1935.

  16. Ortells, M.O. and H.R. Arias, 2010. Molecular mechanisms of nicotine dependence. J. Pediatr. Biochem., 1: 75-89.

  17. Mousa, S.A. and H.R. Arias, 2010. Angiogenesis modulation by nicotine and nicotinic ligands. J. Pediatr. Biochem., 1: 91-104.

  18. Arias, H.R., K.M. Targowska-Duda, C.J. Sullivan, D. Feuerbach, R. Maciejewski and K. Jozwiak, 2010. Different interaction between tricyclic antidepressants and mecamylamine with the human α3β4 nicotinic acetylcholine receptor ion channel. Neurochem. Int., 56: 642-649.
    CrossRef  |  Direct Link  |  

  19. Arias, H.R., H. Gu, D. Feuerbach and D.Q. Wei, 2010. Different interaction between the agonist JN403 and the competitive antagonist methyllycaconitine with the human α7 nicotinic acetylcholine receptor. Biochemistry, 49: 4169-4180.
    CrossRef  |  Direct Link  |  

  20. Arias, H.R., D. Feuerbach, P. Bhumireddy and M.O. Ortells, 2010. Inhibitory mechanisms and binding site location for serotonin selective reuptake inhibitors on nicotinic acetylcholine receptors. Int. J. Biochem. Cell Biol., 42: 712-724.
    CrossRef  |  Direct Link  |  

  21. Arias, H.R., D. Feuerbach, K.M. Targowska-Duda, M.M. Russell and K. Jozwiak, 2010. Interaction of selective serotonin reuptake inhibitors with neuronal nicotinic acetylcholine receptors. Biochemistry, 49: 5734-5742.
    CrossRef  |  Direct Link  |  

  22. Arias, H.R., D. Feuerbach, K.M. Targowska-Duda and K. Jozwiak, 2010. Catharanthine alkaloids are noncompetitive antagonists of muscle nicotinic acetylcholine receptors. Neurochem. Int., 57: 153-161.
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  23. Arias, H.R., A. Rosenberg, K.M. Targowska-Duda, D. Feuerbach, K. Jozwiak, Moaddel and I.W. Weiner, 2010. Tricyclic antidepressants and mecamylamine bind to different sites in the human α4β2 nicotinic receptor ion channel. Int. J. Biochem. Cell Biol., 42: 1007-1018.
    CrossRef  |  Direct Link  |  

  24. Arias, H.R., A. Rosenberg, K.M. Targowska-Duda, D. Feuerbach and R. Moaddel et al., 2010. Interaction of 18-methoxycoronaridine with muscle nicotinic receptors in different conformational states. Biochem. Biophys. Acta. Biomembranes, 1798: 1153-1163.
    Direct Link  |  

  25. Arias, H.R., A. Rosenberg, D. Feuerbach, K.M. Targowska-Duda and X.J. Yuan et al., 2010. Interaction of ibogaine with human α3β4-nicotinic acetylcholine receptors in different conformational states. Int. J. Biochem. Cell Biol., 42: 1525-1535.
    CrossRef  |  Direct Link  |  

  26. Arias, H.R., 2010. Molecular interaction of bupropion with nicotine acetylcholine receptors. J. Pediatr. Biochem., 1: 185-197.

  27. Arias, H.R. and C.E. Bouzat, 2010. Activation and modulation of the nicotine receptor. J. Pediatr. Biochem., 1: 53-73.

  28. Gu, R.X., H. Gu, Z.Y. Xie, J.F. Wang, H.R. Arias, D.Q. Wei and K.C. Chou, 2009. Possible drug candidates for alzheimer's disease deduced from studying their binding interactions with α 7 nicotinic acetylcholine receptor. Med. Chem., 5: 250-262.
    CrossRef  |  Direct Link  |  

  29. Arias, H.R., V. Richards, D. Ng, M.E. Ghafoori, V. Le and S. Mousa, 2009. Role of non-neuronal nicotinic acetylcholine receptors in angiogenesis. Int. J. Biochem. Cell Biol., 41: 1441-1451.
    CrossRef  |  Direct Link  |  

  30. Arias, H.R., H. Xing, K. MacDougall, M.P. Blanton, F. Soti and W.R. Kem, 2009. Interaction of benzylidene-anabaseine analogues with agonist and allosteric sites on muscle nicotinic acetylcholine receptors. Br. J. Pharmacol., 157: 320-320.
    CrossRef  |  Direct Link  |  

  31. Arias, H.R., F. Gumilar, A. Rosenberg, K.M. Targowska-Duda and D. Feuerbach et al., 2009. Interaction of bupropion with muscle-type nicotinic acetylcholine receptors in different conformational states. Biochemistry, 48: 4506-4518.
    CrossRef  |  

  32. Arias, H.R., 2009. Is the inhibition of nicotinic acetylcholine receptors by bupropion involved in its clinical actions? Int. J. Biochem. Cell Biol., 41: 2098-2108.
    CrossRef  |  

  33. Sanghvi, M., A.K. Hamouda, K. Jozwiak, J.R. Trudell, M.P. Blanton and H.R. Arias, 2008. Identifying the binding site(s) for antidepressants on the Torpedo nicotinic acetylcholine receptor: [3H]2-Azidoimipramine photolabeling and molecular dynamics studies. Biochem. Biophys. Acta. Biomembranes, 1778: 2690-2699.

  34. Kem, W.R., F. Soti, S. LeFrancois, K. Wildeboer and K. MacDougall et al., 2006. The nemertine toxin anabaseine and its derivative DMXBA (GTS-21): Chemical and pharmacological properties. Mar. Drugs, 4: 255-273.
    CrossRef  |  Direct Link  |  

  35. Arias, H.R., P. Bhumireddy, G. Spitzmaul, J.R. Trudell and C. Bouzat, 2006. Molecular mechanisms and binding site location for the noncompetitive antagonist crystal violet on nicotinic acetylcholine receptors. Biochemistry, 45: 2014-2026.
    PubMed  |  

  36. Arias, H.R., P. Bhumireddy and C. Bouzat, 2006. Molecular mechanisms and binding site locations for noncompetitive antagonists of nicotinic acetylcholine receptors. Int. J. Biochem. Cell Biol., 38: 1254-1276.
    CrossRef  |  Direct Link  |  

  37. Arias, H.R., 2006. Marine toxins targeting ion channels. Mar. Drugs, 4: 37-69.

  38. Wei, D., S. Sirois, Q.S. Du, H.R. Arias and K.C. Chou, 2005. Theoretical studies of Alzheimer's disease drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine (GTS-21) and its derivatives. Biochem. Biophys. Res. Commun., 338: 1059-1064.
    CrossRef  |  Direct Link  |  

  39. Tuppo, E.E. and H.R. Arias, 2005. The role of inflammation in Alzheimer's disease. Int. J. Biochem. Cell Biol., 37: 289-305.
    CrossRef  |  Direct Link  |  

  40. Arias, H.R. and P. Bhumireddy, 2005. Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors. Curr. Prot. Peptide Sci., 6: 451-472.

  41. Mantipragada, S.B., L.I. Horvath, H.R. Arias, G. Schwarzmann, K. Sandhoff, F.J. Barrantes and D. Marsh, 2003. Lipid-protein interactions and the effect of local anesthetics in acetylcholine receptor-rich membranes from torpedo marmorata electric organ. Biochemistry, 42: 9167-9175.

  42. Gumilar F., H.R. Arias, G. Spitzmaul and C. Bouzat, 2003. Molecular mechanisms of inhibition of nicotinic acetylcholine receptors by tricyclic antidepressants. Neuropharmacology, 45: 964-976.
    CrossRef  |  Direct Link  |  

  43. Arias, H.R., J.R. Trudell, E.Z. Bayer, B. Hester, E.A. McCardy and M.B. Blanton, 2003. Noncompetitive antagonist binding sites in the torpedo nicotinic acetylcholine receptor ion channel. Structure-activity relationship studies using adamantane derivatives. Biochemistry, 42: 7358-7370.
    CrossRef  |  Direct Link  |  

  44. Arias, H.R., W.R. Kem, J.R. Trudell and M.P. Blanton, 2002. Unique general anesthetic binding sites within distinct conformational states of the nicotinic acetylcholine receptor. Int. Rev. Neurobiol., 54: 1-50.
    PubMed  |  

  45. Arias, H.R., E.A. McCardy, E.Z. Bayer, M.J. Gallagher and M.B. Blanton, 2002. Allosterically linked noncompetitive antagonist binding sites in the resting nicotinic acetylcholine receptor ion channel. Arch. Biochem. Biophys., 403: 121-131.
    CrossRef  |  Direct Link  |  

  46. Arias, H.R. and M.P. Blanton, 2002. Molecular and physicochemical aspects of local anesthetics acting on nicotinic acetylcholine receptor-containing membranes. Mini. Rev. Med. Chem., 2: 385-410.

  47. Arias, H.R., E.A. McCardy, M.J. Gallagher and M.B. Blanton, 2001. Interaction of barbiturate analogs with the Torpedo californica nicotinic acetylcholine receptor ion channel. Mol. Pharmacol., 60: 497-506.
    PubMed  |  

  48. Arias, H.R., E.A. McCardy and M.B. Blanton, 2001. Characterization of the dizocilpine binding site on the nicotinic acetylcholine receptor. Mol. Pharmacol., 59: 1051-1060.
    Direct Link  |  

  49. Arias, H.R., 2000. Localization of agonist and competitive antagonist binding sites on nicotinic acetylcholine receptors. Neurochem. Int., 36: 595-645.
    CrossRef  |  Direct Link  |  

  50. Arias, H.R. and M.P. Blanton, 2000. α-Conotoxins. Int. J. Biochem. Cell Biol., 32: 1017-1028.
    CrossRef  |  Direct Link  |  

  51. Arias, H.R., 1999. Role of local anesthetics on both cholinergic and serotonergic ionotropic receptors. Neurosci. Biobehav. Rev., 23: 817-843.
    CrossRef  |  Direct Link  |  

  52. Arias, H.R., 1999. 5-Doxylstearate-induced displacement of phencyclidine from its low-affinity binding sites on the nicotinic acetylcholine receptor. Arch. Biochem. Biophys., 371: 89-97.
    CrossRef  |  Direct Link  |  

  53. Arias, H.R., 1998. Noncompetitive inhibition of nicotinic acetylcholine receptors by endogenous molecules. J. Neurosci. Res., 52: 369-379.
    CrossRef  |  Direct Link  |  

  54. Arias, H.R., 1998. Binding sites for exogenous and endogenous non-competitive inhibitors of the nicotinic acetylcholine receptor. Biochim. Biophys. Acta- Biomembranes, 1376: 173-220.
    CrossRef  |  Direct Link  |  

  55. Figlas, D.N., H.R. Arias, A. Fernandez and D.M. Alperin, 1997. Dramatic saccharide-mediated protection of chaotropic-induced deactivation of concanavalin A. Arch. Biochem. Biophys., 340: 154-158.
    CrossRef  |  Direct Link  |  

  56. Arias, H.R., 1997. Topology of ligand binding sites on the nicotinic acetylcholine receptor. Brain Res. Rev., 25: 133-191.
    CrossRef  |  Direct Link  |  

  57. Arias, H.R., 1997. The high-affinity quinacrine binding site is located at a non-annular lipid domain of the nicotinic acetylcholine receptor. Biochim. Biophys. Acta. Biomembranes, 1347: 9-22.
    CrossRef  |  Direct Link  |  

  58. Arias, H.R., 1996. Temperature and ionic strength dependence of quinacrine binding and quinacrine displacement elicited by high concentrations of agonists on the nicotinic acetylcholine receptor. Arch. Biochem. Biophys., 333: 1-11.
    CrossRef  |  Direct Link  |  

  59. Arias, H.R., 1996. Luminal and non-luminal non-competitive inhibitor binding sites on the nicotinic acetylcholine receptor (Review). Mol. Membr. Biol., 13: 1-17.
    PubMed  |  

  60. Arias, H.R., 1996. Agonist self-inhibitory binding site of the nicotinic acetylcholine receptor. J. Neurosci. Res., 44: 97-105.
    CrossRef  |  Direct Link  |  

  61. Fernandez, A., H. Arias and D. Guerin, 1995. Folding RNA with the minimal loss of entropy. Phys. Rev. E. Stat. Phys. Plasmas Fluids Relat. Interdiscip. Topics, 52: R1299-R1302.
    Direct Link  |  

  62. Arias, H.R., 1995. Agonist-induced displacement of quinacrine from its binding site on the nicotinic acetylcholine receptor: Plausible agonist membrane partitioning mechanism. Mol. Membr. Biol., 12: 339-347.
    PubMed  |  

  63. Arias, H.R. and D.A. Johnson, 1995. Differential agonist-induced displacement of quinacrine and ethidium from their respective histrionicotoxin-sensitive binding sites on the torpedo acetylcholine receptor. Biochemistry, 34: 1589-1595.
    CrossRef  |  

  64. Valenzuela, C.F., A.J. Dowding, H.R. Arias and D.A. Johnson, 1994. Antibody-induced conformational changes in the Torpedo nicotinic acetylcholine receptor: A fluorescence study. Biochemistry, 33: 6586-6594.
    CrossRef  |  Direct Link  |  

  65. Arias, H.R., S. Alonso-Romanowski, E.A. Disalvo and F.J. Barrantes, 1994. Interaction of merocyanine 540 with nicotinic acetylcholine receptor membranes from Discopyge tschudii electric organ. Biochim. Biophys. Acta Biomembranes, 1190: 393-401.
    CrossRef  |  Direct Link  |  

  66. Arias, H.R., C.F. Valenzuela and D.A. Johnson, 1993. Transverse localization of the quinacrine binding site on the Torpedo acetylcholine receptor. J. Biol. Chem., 268: 6348-6355.
    Direct Link  |  

  67. Arias, H.R., C.F. Valenzuela and D.A. Johnson, 1993. Quinacrine and ethidium bind to different loci on the Torpedo acetylcholine receptor. Biochemistry, 32: 6237-6242.
    CrossRef  |  Direct Link  |  

  68. Horvath, L.I., H.R. Arias, H.O. Hankovszky, K. Hideg, F.J. Barrantes and D. Marsh, 1990. Association of spin-labeled local anesthetics at the hydrophobic surface of acetylcholine receptor in native membranes from Torpedo marmorata. Biochemistry, 29: 8707-8713.

  69. Arias, H.R., M.B. Sankaram, D. Marsh and F.J. Barrantes, 1990. Effect of local anaesthetics on steroid-nicotinic acetylcholine receptor interactions in native membranes of Torpedo marmorata electric organ. Biochim. Biophys. Acta (BBA)-Biomembr., 1027: 287-294.
    CrossRef  |  PubMed  |  Direct Link  |  

  70. Arias, H.R. and F.J. Barrantes, 1990. Phosphoinositides and inositol phosphates in Discopyge tschudii electrocyte membranes. Int. J. Biochem., 22: 1387-1392.
    CrossRef  |  

  71. Rotstein, N.P., H.R. Arias, M.I. Aveldano and F.J. Barrantes, 1987. Lipid metabolism in electroplax. J. Neurochem., 49: 1341-1347.
    CrossRef  |  Direct Link  |  

  72. Rotstein, N.P., H.R. Arias, F.J. Barrantes and M.I. Aveldano, 1987. Composition of lipids in elasmobranch electric organ and acetylcholine receptor membranes. J. Neurochem., 49: 1333-1340.
    PubMed  |  

  73. Arias, H.R. and F.J. Barrantes, 1987. High levels of phosphorylation in minor phospholipids of Discopyge tschudii electrocyte membranes. Neurochem. Int., 11: 101-106.
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  74. Arias, H.R. and F.J. Barrantes, 1987. In vitro turnover of oleate and arachidonate in lipids of Discopyge tschudii electrocyte membranes. Comp. Biochem. Physiol., 86: 623-627.
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