Hi, I am Hugo Ruben Arias, My LiveDNA is 54.6092
 
   
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Dr. Hugo Ruben Arias
 
Highest Degree: Ph.D. in Biochemistry from Universidad Nacional del Sur, Argentina
 
Institute: California Northstate University College of Medicine, USA
 
Area of Interest: Chemistry
  •   Neurochemistry
  •   Biochemistry
  •   Biophysics
  •   Molecular Membrane Biology
 
URL: http://livedna.org/54.6092
 
My SELECTED Publications
1:   Arias, H.R. and C.E. Bouzat, 2010. Activation and modulation of the nicotine receptor. J. Pediatr. Biochem., 1: 53-73.
2:   Arias, H.R. and D.A. Johnson, 1995. Differential agonist-induced displacement of quinacrine and ethidium from their respective histrionicotoxin-sensitive binding sites on the torpedo acetylcholine receptor. Biochemistry, 34: 1589-1595.
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3:   Arias, H.R. and F.J. Barrantes, 1987. In vitro turnover of oleate and arachidonate in lipids of Discopyge tschudii electrocyte membranes. Comp. Biochem. Physiol., 86: 623-627.
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4:   Arias, H.R. and F.J. Barrantes, 1987. High levels of phosphorylation in minor phospholipids of Discopyge tschudii electrocyte membranes. Neurochem. Int., 11: 101-106.
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5:   Arias, H.R. and F.J. Barrantes, 1990. Phosphoinositides and inositol phosphates in Discopyge tschudii electrocyte membranes. Int. J. Biochem., 22: 1387-1392.
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6:   Arias, H.R. and M.P. Blanton, 2000. α-Conotoxins. Int. J. Biochem. Cell Biol., 32: 1017-1028.
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7:   Arias, H.R. and M.P. Blanton, 2002. Molecular and physicochemical aspects of local anesthetics acting on nicotinic acetylcholine receptor-containing membranes. Mini. Rev. Med. Chem., 2: 385-410.
8:   Arias, H.R. and P. Bhumireddy, 2005. Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors. Curr. Prot. Peptide Sci., 6: 451-472.
9:   Arias, H.R., 1995. Agonist-induced displacement of quinacrine from its binding site on the nicotinic acetylcholine receptor: Plausible agonist membrane partitioning mechanism. Mol. Membr. Biol., 12: 339-347.
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10:   Arias, H.R., 1996. Agonist self-inhibitory binding site of the nicotinic acetylcholine receptor. J. Neurosci. Res., 44: 97-105.
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11:   Arias, H.R., 1996. Luminal and non-luminal non-competitive inhibitor binding sites on the nicotinic acetylcholine receptor (Review). Mol. Membr. Biol., 13: 1-17.
PubMed  |  
12:   Arias, H.R., 1996. Temperature and ionic strength dependence of quinacrine binding and quinacrine displacement elicited by high concentrations of agonists on the nicotinic acetylcholine receptor. Arch. Biochem. Biophys., 333: 1-11.
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13:   Arias, H.R., 1997. The high-affinity quinacrine binding site is located at a non-annular lipid domain of the nicotinic acetylcholine receptor. Biochim. Biophys. Acta. Biomembranes, 1347: 9-22.
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14:   Arias, H.R., 1997. Topology of ligand binding sites on the nicotinic acetylcholine receptor. Brain Res. Rev., 25: 133-191.
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15:   Arias, H.R., 1998. Binding sites for exogenous and endogenous non-competitive inhibitors of the nicotinic acetylcholine receptor. Biochim. Biophys. Acta- Biomembranes, 1376: 173-220.
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16:   Arias, H.R., 1998. Noncompetitive inhibition of nicotinic acetylcholine receptors by endogenous molecules. J. Neurosci. Res., 52: 369-379.
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17:   Arias, H.R., 1999. 5-Doxylstearate-induced displacement of phencyclidine from its low-affinity binding sites on the nicotinic acetylcholine receptor. Arch. Biochem. Biophys., 371: 89-97.
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18:   Arias, H.R., 1999. Role of local anesthetics on both cholinergic and serotonergic ionotropic receptors. Neurosci. Biobehav. Rev., 23: 817-843.
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19:   Arias, H.R., 2000. Localization of agonist and competitive antagonist binding sites on nicotinic acetylcholine receptors. Neurochem. Int., 36: 595-645.
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20:   Arias, H.R., 2006. Marine toxins targeting ion channels. Mar. Drugs, 4: 37-69.
21:   Arias, H.R., 2009. Is the inhibition of nicotinic acetylcholine receptors by bupropion involved in its clinical actions? Int. J. Biochem. Cell Biol., 41: 2098-2108.
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22:   Arias, H.R., 2010. Molecular interaction of bupropion with nicotine acetylcholine receptors. J. Pediatr. Biochem., 1: 185-197.
23:   Arias, H.R., 2012. Molecular interactions between ligands and nicotinic acetylcholine receptors revealed by studies with acetylcholine binding proteins. J. Thermodyn. Cat., Vol. 3. .
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24:   Arias, H.R., A. Rosenberg, D. Feuerbach, K.M. Targowska-Duda and X.J. Yuan et al., 2010. Interaction of ibogaine with human α3β4-nicotinic acetylcholine receptors in different conformational states. Int. J. Biochem. Cell Biol., 42: 1525-1535.
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25:   Arias, H.R., A. Rosenberg, K.M. Targowska-Duda, D. Feuerbach and R. Moaddel et al., 2010. Interaction of 18-methoxycoronaridine with muscle nicotinic receptors in different conformational states. Biochem. Biophys. Acta. Biomembranes, 1798: 1153-1163.
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26:   Arias, H.R., A. Rosenberg, K.M. Targowska-Duda, D. Feuerbach, K. Jozwiak, Moaddel and I.W. Weiner, 2010. Tricyclic antidepressants and mecamylamine bind to different sites in the human α4β2 nicotinic receptor ion channel. Int. J. Biochem. Cell Biol., 42: 1007-1018.
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27:   Arias, H.R., C.F. Valenzuela and D.A. Johnson, 1993. Quinacrine and ethidium bind to different loci on the Torpedo acetylcholine receptor. Biochemistry, 32: 6237-6242.
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28:   Arias, H.R., C.F. Valenzuela and D.A. Johnson, 1993. Transverse localization of the quinacrine binding site on the Torpedo acetylcholine receptor. J. Biol. Chem., 268: 6348-6355.
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29:   Arias, H.R., D. Feuerbach, K.M. Targowska-Duda and K. Jozwiak, 2010. Catharanthine alkaloids are noncompetitive antagonists of muscle nicotinic acetylcholine receptors. Neurochem. Int., 57: 153-161.
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30:   Arias, H.R., D. Feuerbach, K.M. Targowska-Duda and K. Jozwiak, 2011. Structure-activity relationship of ibogaine analogs interacting with nicotinic acetylcholine receptors in different conformational states. Int. J. Biochem. Cell Biol., 43: 1330-1339.
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31:   Arias, H.R., D. Feuerbach, K.M. Targowska-Duda, M.M. Russell and K. Jozwiak, 2010. Interaction of selective serotonin reuptake inhibitors with neuronal nicotinic acetylcholine receptors. Biochemistry, 49: 5734-5742.
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32:   Arias, H.R., D. Feuerbach, K.M. Targowska-Duda, S. Aggarwal, D.J. Lapinsky and K. Jozwiak, 2012. Structural and functional interaction of (±)-2-(N-tert-butylamino)-3'-iodo-4'-azidopropiophenone, a photoreactive bupropion derivative, with nicotinic acetylcholine receptors. Neurochem. Int., 61: 1433-1441.
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33:   Arias, H.R., D. Feuerbach, P. Bhumireddy and M.O. Ortells, 2010. Inhibitory mechanisms and binding site location for serotonin selective reuptake inhibitors on nicotinic acetylcholine receptors. Int. J. Biochem. Cell Biol., 42: 712-724.
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34:   Arias, H.R., E.A. McCardy and M.B. Blanton, 2001. Characterization of the dizocilpine binding site on the nicotinic acetylcholine receptor. Mol. Pharmacol., 59: 1051-1060.
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35:   Arias, H.R., E.A. McCardy, E.Z. Bayer, M.J. Gallagher and M.B. Blanton, 2002. Allosterically linked noncompetitive antagonist binding sites in the resting nicotinic acetylcholine receptor ion channel. Arch. Biochem. Biophys., 403: 121-131.
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36:   Arias, H.R., E.A. McCardy, M.J. Gallagher and M.B. Blanton, 2001. Interaction of barbiturate analogs with the Torpedo californica nicotinic acetylcholine receptor ion channel. Mol. Pharmacol., 60: 497-506.
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37:   Arias, H.R., F. Gumilar, A. Rosenberg, K.M. Targowska-Duda and D. Feuerbach et al., 2009. Interaction of bupropion with muscle-type nicotinic acetylcholine receptors in different conformational states. Biochemistry, 48: 4506-4518.
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38:   Arias, H.R., H. Gu, D. Feuerbach and D.Q. Wei, 2010. Different interaction between the agonist JN403 and the competitive antagonist methyllycaconitine with the human α7 nicotinic acetylcholine receptor. Biochemistry, 49: 4169-4180.
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39:   Arias, H.R., H. Xing, K. MacDougall, M.P. Blanton, F. Soti and W.R. Kem, 2009. Interaction of benzylidene-anabaseine analogues with agonist and allosteric sites on muscle nicotinic acetylcholine receptors. Br. J. Pharmacol., 157: 320-320.
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40:   Arias, H.R., J.J. Lopez, D. Feuerbach, A. Fierro, M.O. Ortells and E.G. Perez, 2013. Novel 2-(substituted benzyl) quinuclidines inhibit human α7 and α4β2 nicotinic receptors by different mechanisms. Int. J. Biochem. Cell Biol., 45: 2420-2430.
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41:   Arias, H.R., J.R. Trudell, E.Z. Bayer, B. Hester, E.A. McCardy and M.B. Blanton, 2003. Noncompetitive antagonist binding sites in the torpedo nicotinic acetylcholine receptor ion channel. Structure-activity relationship studies using adamantane derivatives. Biochemistry, 42: 7358-7370.
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42:   Arias, H.R., K.M. Targowska-Duda, C.J. Sullivan, D. Feuerbach, R. Maciejewski and K. Jozwiak, 2010. Different interaction between tricyclic antidepressants and mecamylamine with the human α3β4 nicotinic acetylcholine receptor ion channel. Neurochem. Int., 56: 642-649.
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43:   Arias, H.R., M.B. Sankaram, D. Marsh and F.J. Barrantes, 1990. Effect of local anaesthetics on steroid-nicotinic acetylcholine receptor interactions in native membranes of Torpedo marmorata electric organ. Biochim. Biophys. Acta Biomembranes, 1027: 287-294.
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44:   Arias, H.R., M.J. De Rosa, I. Berge, D. Feuerbach and C. Bouzat, 2013. Differential pharmacological activity of JN403 between α7 and muscle nicotinic acetylcholine receptors. Biochemistry, 52: 8480-8488.
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45:   Arias, H.R., M.O. Ortells and D. Feuerbach, 2013. (-)-Reboxetine inhibits muscle nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites. Neurochem. Int., 63: 423-431.
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46:   Arias, H.R., N.B. Fedorov, L.C. Benson, P.M. Lippiello, G.J. Gatto, D. Feuerbach and M.O. Ortells, 2013. Functional and structural interaction of (-)-reboxetine with the human α4β2 nicotinic acetylcholine receptor. J. Pharmacol. Exp. Ther., 344: 113-123.
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47:   Arias, H.R., P. Bhumireddy and C. Bouzat, 2006. Molecular mechanisms and binding site locations for noncompetitive antagonists of nicotinic acetylcholine receptors. Int. J. Biochem. Cell Biol., 38: 1254-1276.
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48:   Arias, H.R., P. Bhumireddy, G. Spitzmaul, J.R. Trudell and C. Bouzat, 2006. Molecular mechanisms and binding site location for the noncompetitive antagonist crystal violet on nicotinic acetylcholine receptors. Biochemistry, 45: 2014-2026.
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49:   Arias, H.R., R.X. Gu, D. Feuerbach, B.B. Gu, Y. Ye and D.Q. Wei, 2011. Novel positive allosteric modulators of the human α7 nicotinic acetylcholine receptor. Biochemistry, 5: 5263-5278.
PubMed  |  
50:   Arias, H.R., S. Alonso-Romanowski, E.A. Disalvo and F.J. Barrantes, 1994. Interaction of merocyanine 540 with nicotinic acetylcholine receptor membranes from Discopyge tschudii electric organ. Biochim. Biophys. Acta Biomembranes, 1190: 393-401.
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51:   Arias, H.R., V. Richards, D. Ng, M.E. Ghafoori, V. Le and S. Mousa, 2009. Role of non-neuronal nicotinic acetylcholine receptors in angiogenesis. Int. J. Biochem. Cell Biol., 41: 1441-1451.
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52:   Arias, H.R., W.R. Kem, J.R. Trudell and M.P. Blanton, 2002. Unique general anesthetic binding sites within distinct conformational states of the nicotinic acetylcholine receptor. Int. Rev. Neurobiol., 54: 1-50.
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53:   Fernandez, A., H. Arias and D. Guerin, 1995. Folding RNA with the minimal loss of entropy. Phys. Rev. E. Stat. Phys. Plasmas Fluids Relat. Interdiscip. Topics, 52: R1299-R1302.
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54:   Figlas, D.N., H.R. Arias, A. Fernandez and D.M. Alperin, 1997. Dramatic saccharide-mediated protection of chaotropic-induced deactivation of concanavalin A. Arch. Biochem. Biophys., 340: 154-158.
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55:   Gu, R.X., H. Gu, Z.Y. Xie, J.F. Wang, H.R. Arias, D.Q. Wei and K.C. Chou, 2009. Possible drug candidates for alzheimer's disease deduced from studying their binding interactions with α 7 nicotinic acetylcholine receptor. Med. Chem., 5: 250-262.
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56:   Gumilar F., H.R. Arias, G. Spitzmaul and C. Bouzat, 2003. Molecular mechanisms of inhibition of nicotinic acetylcholine receptors by tricyclic antidepressants. Neuropharmacology, 45: 964-976.
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57:   Horvath, L.I., H.R. Arias, H.O. Hankovszky, K. Hideg, F.J. Barrantes and D. Marsh, 1990. Association of spin-labeled local anesthetics at the hydrophobic surface of acetylcholine receptor in native membranes from Torpedo marmorata. Biochemistry, 29: 8707-8713.
58:   Kem, W.R., F. Soti, S. LeFrancois, K. Wildeboer and K. MacDougall et al., 2006. The nemertine toxin anabaseine and its derivative DMXBA (GTS-21): Chemical and pharmacological properties. Mar. Drugs, 4: 255-273.
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59:   Mantipragada, S.B., L.I. Horvath, H.R. Arias, G. Schwarzmann, K. Sandhoff, F.J. Barrantes and D. Marsh, 2003. Lipid-protein interactions and the effect of local anesthetics in acetylcholine receptor-rich membranes from torpedo marmorata electric organ. Biochemistry, 42: 9167-9175.
60:   Mousa, S.A. and H.R. Arias, 2010. Angiogenesis modulation by nicotine and nicotinic ligands. J. Pediatr. Biochem., 1: 91-104.
61:   Ortells, M.O. and H.R. Arias, 2010. Molecular mechanisms of nicotine dependence. J. Pediatr. Biochem., 1: 75-89.
62:   Ortells, M.O. and H.R. Arias, 2010. Neuronal networks of nicotine addiction. Int. J. Biochem. Cell Biol., 42: 1931-1935.
63:   Perez, E.G., C. Ocampo, D. Feuerbach, J. Lopez, R. Tapia and H.R. Arias, 2013. Novel 1-(1-benzyl-1H-indol-3-yl)-N, N, N-trimethylmethanaminium iodides are competitive antagonists of the human α4β2 and α7 nicotinic acetylcholine receptors. Med. Chem. Commun., 4: 1166-1170.
64:   Radhakrishnan, R., A. Santamaria, L. Escobar and H.R. Arias, 2013. The β4 nicotinic receptor subunit modulates the chronic antidepressant effect mediated by bupropion. Neurosci. Lett., 555: 68-72.
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65:   Rotstein, N.P., H.R. Arias, F.J. Barrantes and M.I. Aveldano, 1987. Composition of lipids in elasmobranch electric organ and acetylcholine receptor membranes. J. Neurochem., 49: 1333-1340.
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66:   Rotstein, N.P., H.R. Arias, M.I. Aveldano and F.J. Barrantes, 1987. Lipid metabolism in electroplax. J. Neurochem., 49: 1341-1347.
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67:   Sanghvi, M., A.K. Hamouda, K. Jozwiak, J.R. Trudell, M.P. Blanton and H.R. Arias, 2008. Identifying the binding site(s) for antidepressants on the Torpedo nicotinic acetylcholine receptor: [3H]2-Azidoimipramine photolabeling and molecular dynamics studies. Biochem. Biophys. Acta. Biomembranes, 1778: 2690-2699.
68:   Santamaria, A., and H.R. Arias, 2010. Neurochemical and behavioral effects elicited by bupropion and diethylpropion in rats. Behav. Brain Res., 211: 132-139.
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69:   Targowska-Duda, K.M., H.R. Arias and K. Jozwiak, 2013. Application of in silico methods to support experimental data: Interactions of antidepressants with nicotinic acetylcholine receptors. Open Conf. Proc. J., 4: 11-22.
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70:   Targowska-Duda, K.M., K. Jozwiak and H.R. Arias, 2013. Role of the nicotinic receptor β4 subunit in the antidepressant activity of novel N, 6-dimethyltricyclo [5.2. 1.0 2, 6] decan-2-amine enantiomers. Neurosci. Lett., 553: 186-190.
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71:   Taylor, D.H., P.N. Burman, D.M. Hansen, R.S. Wilcox and B.R. Larsen et al., 2013. Nicotine enhances the excitability of gaba neurons in the ventral tegmental area via activation of alpha 7 nicotinic receptors on glutamate terminals. Biochem. Pharmacol., .
72:   Tuppo, E.E. and H.R. Arias, 2005. The role of inflammation in Alzheimer's disease. Int. J. Biochem. Cell Biol., 37: 289-305.
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73:   Valenzuela, C.F., A.J. Dowding, H.R. Arias and D.A. Johnson, 1994. Antibody-induced conformational changes in the Torpedo nicotinic acetylcholine receptor: A fluorescence study. Biochemistry, 33: 6586-6594.
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74:   Wei, D., S. Sirois, Q.S. Du, H.R. Arias and K.C. Chou, 2005. Theoretical studies of Alzheimer's disease drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine (GTS-21) and its derivatives. Biochem. Biophys. Res. Commun., 338: 1059-1064.
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