Hi, I am Marcus Vinicius Nora De Souza, My LiveDNA is 55.6095
 
   
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Dr. Marcus Vinicius Nora De Souza
 
Highest Degree: Ph.D. in Organic and Biorganic Chemistry from Universite d`Orsay, France
 
Institute: Institute of Drug Technology Far-Manguinhos, Brazil
 
Area of Interest: Chemistry
  •   Drug Design
  •   Medicinal Chemistry
  •   Molecular Structure
  •   Crystallography
 
URL: http://livedna.org/55.6095
 
My SELECTED Publications
1:   Almeida, M.V., F.M. Teixeira, M.V.N. de Souza, G.W. Amarante and C.C.S. Alves et al., 2007. Thalidomide analogs from diamines: Synthesis and evaluation as inhibitors of TNF-alfa production. Chem. Pharm. Bull., 55: 223-226.
2:   Almeida, M.V., M.V.N. de Souza, N. Barbosa, G.W. Amarante and S.H. Cardoso, 2007. Synthesis and antimicrobial activity of pyridine derivatives substituted at C-2 and C-6 positions. Lett. Drug Des. Dis., 4: 149-153.
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3:   Almeida, M.V., S.H. Cardoso, J.V. Assis and M.V.N. de Souza, 2007. Synthesis of 2-mercaptobenzothiazole and 2-mercaptobenzimidazole derivatives condensed with carbohydrates as a potential antimicrobial agents. J. Sulfur Chem., 28: 17-22.
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4:   Andrade, A.A., F. de Pilla Varotti, I.O. de Freitas, M.V. de Souza, T.R. Vasconcelos, N. Boechat and A.U. Krettli, 2007. Enhanced activity of mefloquine and artesunic acid against Plasmodium falciparum in vitro and P. berghei in mice by combination with ciprofloxacin. Eur. J. Pharmacol., 558: 194-198.
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5:   Baddeley, T.C., R.A. Howie, C.H.L. da Silva, C.R. Kaiser and M.V.N. de Souza, J.L. Wardell and S.M.S.V. Wardell, 2009. (Pyrazinecarbonyl)hydrazone halobenzaldehydes: Supramolecular arrays generated by face to face stacking of ribbons, formed from C-H-O interactions. Zeitschrift fur Kristallographie, 224: 506-514.
6:   Boechat, N., J.C.S. da Costa, J.D.S. Mendonca, K.C. Paes and E.L. Fernandes et al., 2005. Simple reduction of heteroaromatic esters to alcohols using a sodium borohydride-methanol system. Synthetic Commun.: Int. J. Rapid Commun. Synthetic Organic Chem., 35: 3187-3190.
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7:   Candea, A.L.P., M.L. Ferreira, K.C. Pais, L.N.F. Cardoso and C.R. Kaiser et al., 2009. Synthesis and antitubercular activity of 7-chloro-4-quinolinylhydrazones derivatives. Bioorg. Med. Chem. Lett., 19: 6272-6274.
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8:   Cardoso, S.H., M.B. Barreto, M.C.S. Lourenco, M.G.M.O. Henriques, A.L.P. Candea, C.R. Kaiser and M.V.N. de Souza, 2011. Antitubercular activity of new coumarins. Chem. Biol. Drug Des., 77: 489-493.
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9:   Cardoso, S.H., M.V. de Almeida, J.V. Assis, R. Diniz, N.L. Speziali and M.V.N. de Souza, 2008. Synthesis and characterization of n-hydroxyalkyl and oxazolinyl ethionamide derivatives. J. Sulfur Chem., 29: 145-149.
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10:   Carvalho, S.A., E.F. da Silva, M.V.N. de Souza, E.R.T. Tiekink, J.L. Wardell and S.M.S.V. Wardell, 2010. (2E)-N'-Benzoyl-3-(4-nitrophenyl)prop-2-enohydrazide Acta Crystallographica, 66: o150-o151.
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11:   Carvalho, S.A., E.F. da Silva, M.V.N. de Souza, M.C.S. Lourenco and F.R.C. Vicente, 2008. Synthesis and antimycobacterial evaluation of new trans-cinnamic acid hydrazide derivatives. Bioorg. Med. Chem. Lett., 18: 538-541.
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12:   Castro, A.A., M.V.N. de Souza, N.A. Rey and P.A.M. Farias, 2011. Determination of efavirenz in diluted alkaline electrolyte by cathodic adsorptive stripping voltammetry at the mercury film electrode. J. Braz. Chem. Soc., 22: 1662-1668.
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13:   Coimbra, E.S., A.D. Silva, R.M.P. Dias, R.C.N.R. Corrales, M.L.F. Bispo, C.R. Kaiser and M.V.N. de Souza, 2011. Amodiaquine analogs. Synthesis and anti-leishmanial activity. Mediterranean J. Chem., 3: 106-113.
14:   Costa, J.C.S., J.S. Neves, M.V.N. de Souza, R.A. Siqueira and N.C. Romeiro ., 2008. Synthesis and antispasmodic activity of lidocaine derivatives endowed with reduced local anesthetic action. Bioorg. Med. Chem. Lett., 18: 1162-1166.
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15:   Cunico, W., C.A. Cechinel, H.G. Bonacorso, M.A. Martins and N. Zanatta et al., 2006. Antimalarial activity of 4-(5-trifluoromethyl-1< i> H-pyrazol-1-yl)-chloroquine analogues. Bioorganic Med. Chem. Lett., 16: 649-653.
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16:   Cunico, W., C.R.B. Gomes, M.L.G. Ferreira, T.G. Ferreira, D. Cardinot, M.V.N. De Souza and M.C.S. Lourenco, 2011. Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives. Eur. J. Med. Chem., 46: 974-978.
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17:   Da Costa, C.F., A.C. Pinheiro, M.V. de Almeida, M.C.S. Lourenco and M.V.N. de Souza, 2012. Synthesis and antitubercular activity of novel amino acid derivatives. Chem. Biol. Drug Des., 79: 216-222.
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18:   Da Silva, A.D., M.V. De Almeida, M.V. De Souza and M.R. Couri, 2003. Biological activity and synthetic metodologies for the preparation of fluoroquinolones, a class of potent antibacterial agents. Curr. Med. Chem., 10: 21-39.
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19:   Da Silva, J.A.F., N.V. de Castro, D.P. de Jesus, A.F. Faria, M.V.N. De Souza and M.A.L. de Oliveira, 2010. Fast determination of ethambutol in pharmaceutical formulations using capillary electrophoresis with capacitively coupled contactless conductivity detection. Electrophoresis, 31: 570-574.
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20:   De Almeida, M., L. de Oliviera, E. Cesar and M. de Souza, 2003. Synthesis of platinum complexes from n-benzyl-2-aminoethanethiol derivatives. Scient. World J., 3: 348-353.
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21:   De Almeida, M.V., M.F. Saraiva, M.V. de Souza, C.F. da Costa, F.R. Vicente and M.C. Lourenco, 2007. Synthesis and antitubercular activity of lipophilic moxifloxacin and gatifloxacin derivatives. Bioorg. Med. Chem. Lett., 17: 5661-5664.
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22:   De Ferreira, M.L., M.V.N. de Souza, R.A. Howie, E.R.T. Tiekink, J.L. Wardell and S.M.S.V. Wardell, 2009. 3-[(E)-(7-Chloro-4-quinolyl)hydrazonomethyl]benzonitrile monohydrate. Acta Crystallographica, 65: o3239-o3240.
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23:   De Lima, M.F., M.V.N. de Souza, E.R.T. Tiekink, J.L. Wardell and S.M.S.V. Wardell, 2009. N-(2,6-Dimethylphenyl)-2-(2-thienyl)acetamide. Acta Crystallographica, 65: o3203-o3203.
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24:   De Pilla Varotti, F., A.C.C. Botelho, A.A. Andrade, R.C. de Paula and E.M.S. Fagundes et al., 2008. Synthesis, antimalarial activity and intracellular targets of MEFAS, a new hybrid compound derived from mefloquine and artesunate. Antimicrob. Agents Chemother., 52: 3868-3874.
25:   De Souza, M.C., T. Goncalves-Silva, M. Moreth, Claudia R.B. Gomes, C.R. Kaiser, M.G.M.O. Henriques and M.V.N. de Souza, 2012. Synthesis and in vivo antimalarial evaluation of novel hydroxyethylamine derivatives. Med. Chem., 8: 266-272.
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26:   De Souza, M.V., 2006. Promising drugs against tuberculosis. Recent Pat. Antiinfect. Drug Discov., 1: 33-44.
PubMed  |  
27:   De Souza, M.V., 2006. TEMPO (2, 2, 6, 6-tetramethylpiperidine-N-oxyl) an important reagent in alcohol oxidation and its application in synthesis of natural products. Mini Revi. Organic Chem., 3: 155-165.
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28:   De Souza, M.V., S.M. Wardell, J.L. Wardell, J.N. Low and C. Glidewell, 2007. 4-Cyanobenzaldehyde isonicotinoylhydrazone monohydrate: A three-dimensional hydrogen-bonded framework structure. Acta Crystallogr. Section C, Crystal Struct. Commun., C63: 166-168.
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29:   De Souza, M.V.N. and R.H. Dodd, 1998. Ortho directed lithiation studies of 4-chloropicolinanilide: Introduction of functional groups at c-3 and their elaboration to chain extended derivatives via carbon-carbon bond formation. Heterocycles, 47: 811-827.
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30:   De Souza, M.V.N., 2004. (+)-Discodermolide: A marine natural product against cancer. Scient. World, 4: 415-436.
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31:   De Souza, M.V.N., 2004. Entry inhibitors: A new class of AIDS drugs. Lett. Drugs Discovery Design, 1: 184-193.
32:   De Souza, M.V.N., 2005. New fluoroquinolones: A class of potent antibiotics. Mini Rev. Med. Chem., 5: 1009-1017.
PubMed  |  Direct Link  |  
33:   De Souza, M.V.N., 2005. Plants and fungal products with activity against tuberculosis. Scient. World J., 5: 609-628.
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34:   De Souza, M.V.N., 2005. Recent synthetic methodologies and your application in synthesis of natural products. Mini Rev. Organic Synthesis, 2: 139-145.
35:   De Souza, M.V.N., 2005. Synthesis and biological activity of natural thiazoles: An important class of heterocyclic compounds. J. Sulfur Chem., 26: 429-449.
36:   De Souza, M.V.N., 2006. Current status and future prospects for new therapies for pulmonary tuberculosis. Curr. Opin. Pulm. Med., 12: 167-171.
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37:   De Souza, M.V.N., 2006. Marine natural products against tuberculosis. Sci. World J., 6: 847-861.
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38:   De Souza, M.V.N., 2007. Halogen dance reaction and its application in organic synthesis. Curr. Org. Chem., 11: 637-646.
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39:   De Souza, M.V.N., 2008. Compounds containing oxazolidinone, triazole and macrolide groups in the treatment of mycobacterial infections. Expert Opin. Ther. Patents, 18: 1101-1105.
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40:   De Souza, M.V.N., 2009. Promising candidates in clinical trials against multidrug-resistant tuberculosis (MDR-TB) based on natural products. Fitoterapia, 80: 453-460.
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41:   De Souza, M.V.N., A.C. Pinheiro, E.R.T. Tiekink, S.M.S.V. Wardell and J.L. Wardell, 2011. Benzyl N-(1-{N'-[(E)-2-chlorobenzylidene]hydrazinecarbonyl}-2-hydroxyethyl) carbamate. Acta Crystallographica, 67: o1868-o1869.
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42:   De Souza, M.V.N., A.G. Barreto, L.R.M. Estevao, J.R. Biscaia and E.C. Carvalho et al., 2005. Evaluating of the effect of the antimonium pentachloride feed rate to ensure safe conditions for the synthesis of meglumine antimoniate. Ind. Eng. Chem. Res., 44: 6578-6582.
43:   De Souza, M.V.N., C.H.S. Lima, J.L. Wardell, S.M.S.V. Wardell and E.R.T. Tiekink, 2011. N'-[(E)-2-Methoxybenzylidene]pyrazine-2-carbohydrazide. Acta Crystallographica, 67: 1714-1715.
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44:   De Souza, M.V.N., E.L. Fernandes, K.C. Pais, T.A. Vasconcelos, S.M.S.V. Wardell and J.L. Wardell, 2006. Cyclization studies of 2-chloro-N-(methyl-2-pyridinyl)nicotinamides to methyl 5-oxo-5,6-dihydrodipyrido[1,2-a:3',2'-e]pyrimidin-11-ium chlorides. J. Chem. Res., 2: 93-97.
45:   De Souza, M.V.N., E.R.T. Tiekink, J.L. Wardell and S.M.S.V. Wardelld, 2009. 4-[(2-Chloroethyl)amino]quinolinium chloride monohydrate. Acta Crystallographica, 65: o3120-o3121.
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46:   De Souza, M.V.N., I. Neves Junior, G.B.P. Miranda, M.C.S. Lourenco, T.A. Vasconcelos and K.C. Pais, 2006. Synthesis and in vitro anti-tubercular activity of a series of N-(disubstitutedbenzoyl)isoniazid derivatives. Lett. Drug Design Discovery, 3: 424-428.
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47:   De Souza, M.V.N., J.L. Wardell, J.N. Low and C. Glidewell, 2006. Pyrrole-2-carbaldehyde isonicotinoylhydrazone monohydrate redetermined at 120K. Acta Crystallographica Sect. C Crystal Struc. Commun., C62: 47-49.
48:   De Souza, M.V.N., J.L. Wardell, S.M.S.V. Wardell and J.N. Low, 2005. Four nitrobenzaldehyde isonicotinoylhydrazones at 120K: four different supramolecular strucutures in two and three dimensions. Acta Crystallographica Sect. C Crystal Struc. Commun., 61: 683-689.
49:   De Souza, M.V.N., J.L. Wardell, S.M.S.V. Wardell, J.N. Low and C. Glidewell, 2006. 5-Chloro-2-nitrobenzaldehyde isonicotinoylhydrazone:a three-dimensional frameworkbuilt from N-H...N and C-H...O hydrogen bonds. Acta Crystallographica Sect. E, 62: 3361-3363.
50:   De Souza, M.V.N., J.L. Wardell, S.M.S.V. Wardell, M.L. Ferreira, T.A. Vasconcelos, J.N. Low and C. Glidewell, 2005. Pi-Stacked hydrogen-bonded chains of rings in 2,4-difluorobenzaldehyde isonicotinoylhydazone and hydrogen-bonded sheets in 2,3-dichlorobenzaldehyde isonicotinoylhydrazone. Acta Crystallographica Sect. C, 61: 617-620.
51:   De Souza, M.V.N., J.L. Wardell, S.M.S.V. Wardell, S.W. Ng and E.R.T. Tiekink, 2011. 2-{[2,8-Bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-ium 3-amino-5-nitrobenzoate sesquihydrate. Acta Crystallographica, 67: o3019-o3020.
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52:   De Souza, M.V.N., K.C. Pais, C.R. Kaiser, M.A. Peralta, M.L. Ferreira and M.C.S. Lourenco, 2009. Synthesis and in vitro antitubercular activity of a series of quinoline derivatives. Bioorg. Med. Chem., 17: 1474-1480.
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53:   De Souza, M.V.N., M.C.S. Lourenco, M.A. Peralta, R.S.B. Goncalves and T.C.M. Nogueira et al., 2008. Synthesis and biological evaluation of N,N'-di(thiopheneacetyl)diamines series as antitubercular agents. Phosphorus, Sulfur Silicon Relat. Elem., 183: 2990-2997.
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54:   De Souza, M.V.N., M.L. Ferreira and L.N.F. Cardoso, 2011. Sodium chlorite (NaClO2): An important reagent in alcohol and aldehyde oxidation and its application in total synthesis of natural products. J. Biol. Active Prod. Nat., 1: 52-80.
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55:   De Souza, M.V.N., M.L. Ferreira, A.C. Pinheiro, M.F. Saraiva, M.V. de Almeida and M.S. Valle, 2008. Synthesis and biological aspects of mycolic acids: An important target against Mycobacterium tuberculosis. Scient. World J., 8: 720-751.
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56:   De Souza, M.V.N., M.L. Ferreira, T.C.M. Nogueira, R.S.B. Goncalves, M.A. Peralta, M.C.S. Lourenco and F.R.C. Vicente, 2008. Synthesis and biological evaluation of N-(Alkyl)-2-thiophen-2-ylacetamides series as a new class of antitubercular agents. Lett. Drug Des. Dis., 5: 221-224.
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57:   De Souza, M.V.N., M.V. Almeida, M.L. Hyaric, E.T. Silva, A.S.M. Almeida and R.M. Santiago, 2003. Synthesis of 2-deoxystreptamine derivatives. J. Carbohydrate Chem., 22: 733-742.
58:   De Souza, M.V.N., N. Boechat, J.S. Mendonca, E.L. Fernandes, K.C. Pais, J.C.S. Costa and T.A. Vasconcelos, 2006. Simple reduction of ethyl, isopropyl and benzyl aromatic esters to alcohols using sodium borohydride-methanol system. ARKIVOC, 1: 128-133.
59:   De Souza, M.V.N., R.A. Howie, E.R.T. Tiekink, J.L. Wardell and S.M.S.V. Wardell, 2010. 7-Chloro-4-[(E)-N'-(4-fluorobenzylidene)hydrazinyl]quinoline monohydrate. Acta Crystallographica, 66: o152-o153.
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60:   De Souza, M.V.N., R.H. Dodd and H. Zao, 2004. Synthesis of 2,3-dihydrofuro[3,2-c]pyridine-3,4-dicarboxylic acid, a conformationally constrained analogue of the subtype selective NMDA receptor agonist homoquinolinic acid. Heterocycle, 64: 261-275.
61:   De Souza, M.V.N., R.S.B. Goncalves, J.L. Wardell, S.M.S.V. Wardell and E.R.T. Tiekink, 2011. Benzyl 2-{[2,8-bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidine-1-carboxylate. Acta Crystallographica, 67: o3313-o3314.
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62:   De Souza, M.V.N., S. Cuffini, S.M.S.V. Wardell, J.L. Wardell, T.A. Vasconcelos, A.G. Oliveira and C. Glidewell, 2006. Nine N-aryl-2-chloronicotinamides: Supramolecular structures in one, two and three dimensions. Acta Crystallogr. Section B, Struct. Sci., B62: 651-665.
63:   De Souza, M.V.N., S.C.P. Mello, N. Boechat, J.S. Mendonca and J.A. Costa, 2004. Simple reduction of methyl aromatic esters to alcohols using. Tetrahedron Lett., 45: 6021-6022.
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64:   De Souza, M.V.N., S.M.S.V. Wardell and R.A. Howie, 2005. 2-chloropyridine-3-carboxylic acid. Acta Crystallographica Sect. E, 61: 1347-1349.
65:   De Souza, M.V.N., S.M.S.V. Wardell, J.L. Wardell, J.N. Low and C. Glidewell, 2007. N-(5-Chloro-2-nitrobenzoyl)-N'-isonicotinoylhydrazine: A three-dimensional framework containing four types of hydrogen bond. Acta Crystallographica. Section E, E63: 230-232.
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66:   De Souza, M.V.N., S.M.S.V. Wardell, J.L. Wardell, T.A. Vasconcelos and E.M. Carvalho, 2006. Comparison of the reactivities of 2-mercaptoaniline and 2-hydroxyaniline with 2-chloronicotinoyl chloride. J. Sulfur Chem., 27: 193-202.
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67:   De Souza, M.V.N., T.A. Vasconcelos, S.C.P. Mello, S.M.S.V. Wardell and M.A. Peralta et al., 2005. Synhtesis and anti-mycobacterial activity of N'[(E)-(disubstituted-phenyl)methylidene]isonicotino-hydrazine derivatives. Lett. Drug Design Discovery, 2: 563-566.
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68:   De Souza, M.V.N., T.A. Vasconcelos, S.M.S. Wardell, J.L. Wardell, J.N. Low and C. Glidewell, 2005. Supramolecular structures of three isomeric 2-chloro-N-(nitrophenyl)nicotinamides. Acta Crystallographica Sect. C Crystal Struc. Commun., 61: 204-208.
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69:   De Souza, M.V.N., T.A. Vasconcelos, S.M.S.V. Wardell, J.L. Wardell, J.N. Low and C. Glidewell, 2006. Hydrogen-bonded framework structures in 4-[(4-chloro-3-nitrobenzoyl)-hydrazinocarbonyl]pyridiniumchloride and N-3,5-dinitrobenzoyl-N'-isonicotinoylhydrazine. Acta Crystallogr. Section C, Crystal Struct. Commun., C62: 222-226.
70:   De Souza, M.V.N., T.A. Vasconcelos, S.M.S.V. Wardell, J.L. Wardell, M.L. Ferreira and R.A. Howie, 2005. 8-Methyl-5-oxo-5,6-dihydrodipyrido[1,2-a:3,2-e]-pyrimidin-11-ium chloride trihydrate 120k. Acta Crystall Struc. Sect. E, E61: 3579-3581.
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71:   De Souza, M.V.N., T.R. Vasconcelos, M.V. Almeida and S.H. Cardoso, 2006. Fluoroquinolones: An important class of antibiotics against tuberculosis. Curr. Med. Chem., 13: 455-463.
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72:   Estiarte, M., M.V. de Souza, X. del Rio, R.H. Dodd, M. Rubiralta and A. Diez, 1999. Synthesis and synthetic applications of 3-amino-< i> Δ< sup> 5-piperidein-2-ones: Synthesis of methionine-derived pseudopeptides. Tetrahedron, 55: 10173-10186.
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73:   Facchinetti, V., C.R.B. Gomes, M.V.N. de Souza and T.R.A. 2012. Perspectives on the development of novel potentially active quinolones against tuberculosis and cancer. Mini-Rev. Med. Chem., 12: 866-874.
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74:   Faria, A.F., J.P. Vasconcelos, R.S.B. Goncalves, M.V.N. de Souza and M.A.L. de Oliveira, 2012. Simultaneous analysis of isoniazid and its impurities by CZE. Chromatographia, 75: 1335-1339.
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75:   Faria, A.F., L.F. Marcellos, J.P. Vasconcelos, M.V.N. De Souza and A.L. Silva Jr. et al., 2011. Ethambutol analysis by copper complexation in pharmaceutical formulations: Spectrophotometry and crystal structure. J. Braz. Chem. Soc., 22: 867-874.
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76:   Faria, A.F., M.V. de Souza, M.V. de Almeida and M.A. de Oliveira, 2006. Simultaneous separation of five fluoroquinolone antibiotics by capillary zone electrophoresis. Analytica Chimica Acta, 579: 185-192.
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77:   Faria, A.F., M.V.N. de Souza and M.A.L. de Oliveira, 2008. Validation of capillary zone electrophoresis method for the determination of ciprofloxacin, gatifloxacin, moxifloxacin and ofloxacin in pharmaceutical formulation. J. Brazil. Chem. Soc., 19: 389-396.
78:   Faria, A.F., M.V.N. de Souza, R.E. Bruns and M.A.L. de Oliveira, 2008. Optimization of an electrolyte system for analysis of ethambutol in pharmaceutical formulations by capillary zone electrophoresis using complexation with copper(II). J. Chromatogr., 1202: 222-228.
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79:   Ferreira, M.L., L.N.F. Cardoso, R.S.B. Goncalves, E.T. Silva, M.C.S. Lourenco and M.V.N. de Souza, 2008. Synthesis and antitubercular evaluation of N'-[(E)-(hydroxy, methoxy and ethoxy-substituted-phenyl) Methylidene]isonicotinohydrazide derivatives. Lett. Drug Des. Discovery, 5: 137-140.
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80:   Ferreira, M.L., T.R.A. Vasconcelos, E.M. de Carvalho, M.C.S. Lourenco and S.M.S.V. Wardell et al., 2009. Synthesis and antitubercular activity of novel Schiff bases derived from D-mannitol. Carbohydr. Res., 344: 2042-2047.
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81:   Gomes, C.R.B., M. Moreth, D. Cardinot, V. Kopke, W. Cunico, M.C.S. Lourenco and M.V.N. de Souza, 2011. Synthesis and antimycobacterial activity of novel amino alcohols containing central core of the anti-HIV drugs Lopinavir and Ritonavir. Chem. Biol. Drug Des., 78: 1031-1034.
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82:   Goncalves, R.S.B., A.C. Pinheiro, E.T. Da Silva, J.C.S. Da Costa, C.R. Kaiser and M.V.N. De Souza, 2011. Simple methodology for the preparation of amino alcohols from amino acid esters using NaBH4-methanol in THF. Synthetic Commun.: Int. J. Rapid Commun. Synthetic Organic Chem., 41: 1276-1281.
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83:   Goncalves, R.S.B., C.R. Kaiser, M.C.S. Lourenco, F.A.F.M. Bezerra and M.V.N. De Souza et al., 2012. Mefloquine-oxazolidine derivatives, derived from mefloquine and arenecarbaldehydes: In vitro activity including against the multidrug-resistant tuberculosis strain T113. Bioorg. Med. Chem., 20: 243-248.
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84:   Goncalves, R.S.B., C.R. Kaiser, M.V.N. de Souza, J.L. Wardell, S.M.S.V. Wardell and E.R.T. Tiekink, 2011. 2-{1-[2,8-Bis(trifluoromethyl)quinolin-4-yl]-3,5,6,7,8,8a-hexahydro-1H-1,3-oxazolo[3,4-α]pyridin-3-yl}phenol. Acta Crystallographica, 67: o1656-o1657.
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85:   Goncalves, R.S.B., C.R. Kaiser, M.V.N. de Souza, J.L. Wardell, S.M.S.V. Wardell and R.A. Howie, 2011. Structures of 4-{3-(X-phenyl)perhydro-1,3-oxazolo[3,4-a]pyridin-1-yl}-2,8-bis(trifluoromethyl)quinolines (X = H, 2-O2N, 3-O2N and 4-O2N), derived from mefloquine. Zeitschrift fur Kristallographie, 226: 793-803.
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86:   Goncalves, R.S.B., M.V.N. de Souza, J.L. Wardell, S.M.S.V. Wardell and E.R.T. Tiekink, 2011. tert-Butyl 2-{[2,8-bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidine-1-carboxylate. Acta Crystallographica, 67: o3315-o3316.
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87:   Goncalves, R.S.B., M.V.N. de Souza, S.M.S.V. Wardell, J.L. Wardell and E.R.T. Tiekink, 2011. (R*,S*)-(±)-1-(2-[2,8-Bis(trifluoromethyl)quinolin-4-yl](hydroxy)methylpiperidin-1-yl)ethanone methanol monosolvate. Acta Crystallographica, 67: 2714-2715.
88:   Howie, A.R., E.R.T. Tiekink, J.L. Wardell, S.M.S.V. Wardell and M.V.N. de Souza, 2009. 7-Chloro-4-[(E)-(3-chlorobenzylidene)hydrazinyl]-14-quinolinium 3-chlorobenzoate. Acta Crystallographica, 65: 3204-3205.
89:   Howie, R.A., M.V.N. De Souza, A.C. Pinheiro, C.R. Kaiser, J.L. Wardell and S.M.S.V. Wardell, 2011. (S)-1-[N-(Benzylidene)hydrazinylcarbonyl]-2-hydroxyethyl carbamate esters: Layered structures created from X-H····O (X= N,O) hydrogen-bonds. Zeitschrift fur Kristallographie, 226: 483-491.
90:   Howie, R.A., M.V.N. de Souza, S.M.S.V. Wardell, J.L. Wardell and E.R.T. Tiekink, 2010. N'-[(E)-2,6-Dichlorobenzylidene]pyrazine-2-carbohydrazide. Acta Crystallographica, 66: o178-o179.
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91:   Howie, R.A., R.S. Goncalves, M.V.N. de Souza, E.R.T. Tiekink and J.L. Wardell, 2010. 2-Bromopyridine-3-carboxylic acid. Acta Crystallographica, 66: 486-486.
92:   Kaiser, C.R., A.C. Pinheiro, M.V.N. de Souza, S.M.S.V. Wardell and J.L. Wardell, 2008. Formation of N-acyl-N,N/-dicyclohexylureas from DCC and arenecarboxylic acids in the presence of hydroxybenzotriazol in CH2Cl2 at room temperature. J. Chem. Res, 5: 468-472.
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93:   Kaiser, C.R., K.C. Pais, M.V.N. de Souza, J.L. Wardell, S.M.S.V. Wardell and E.R.T. Tiekink, 2009. Assessing the persistence of the N-H-N hydrogen bonding leading to supramolecular chains in molecules related to the anti-malarial drug, chloroquine. Cryst. Eng. Commun., 11: 1133-1140.
94:   Lima, C.H.S., M.G.M.O. Henriques, A.L.P. Candea, M.C.S. Lourenco, F.A.F.M. Bezerra, C.R. Kaiser and M.V.N. De Souza, 2011. Synthesis and antimycobacterial evaluation of N'-(E)-heteroaromaticpyrazine-2-carbohydrazide derivatives. Med. Chem., 7: 245-249.
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95:   Lourenco, M.C., I.N. Junior and M.V. de Souza, 2007. In vitro activity of ciprofloxacin, ofloxacin, levofloxacin, sparfloxacin and gatifloxacin against multidrug-resistant Mycobacterium tuberculosis in Rio de Janeiro Brazil. Med. Mal. Infect., 37: 295-298.
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96:   Lourenco, M.C.S., M.L. Ferreira, M.V.N. de Souza, M.A. Peralta, T.R.A. Vasconcelos and M.G.M.O. Henriques, 2008. Synthesis and anti-mycobacterial activity of (E)-N′-(monosubstituted-benzylidene)isonicotinohydrazide derivatives. Eur. J. Med. Chem., 43: 1344-1347.
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97:   Lourenco, M.C.S., M.V.N. de Souza, A.C. Pinheiro, M.L. Ferreira, R.S.B. Goncalves, T.C.M. Nogueira and M.A. Peralta, 2007. Evaluation of anti-tubercular activity of nicotinic and isoniazid analogues. Arkivoc, 15: 181-191.
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98:   Low, J.N., S.M. Wardell, M.V. Souza, J.L. Wardell and C. Glidewell, 2006. 2,4-Dimethylbenzaldehyde isonicotinoylhydrazone trihydrate: A three-dimensional hydrogen-bonded framework structure. Acta Crystallogr C, 62: 444-446.
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99:   Marcellos, L.F., A.F. Faria, M.V.N. de Souza, M.R. Almeida, G.P. Sabin, R.J. Poppi and M.A.L. de Oliveira, 2012. Simultaneous analysis of first-line anti-tuberculosis drugs in tablets by UV spectrophotometry compared to capillary zone electrophoresis. Central Eur. J. Chem., 10: 1808-1816.
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100:   Mazzoccoli, L., S.H. Cadoso, G.W. Amarante, M.V.N. de Souza and R. Domingues et al., 2012. Novel thalidomide analogues from diamines inhibit pro-inflammatory cytokine production and CD80 expression while enhancing IL-10. Biomed. Pharmacother., 66: 323-329.
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101:   Montenegro, R.C., L.V. Lotufo, M.O. Moraes, C.O. Pessoa and F.A R. Rodrigues et al., 2012. Synthesis and antitumoral evaluation of benzyl (1S)-2-[2-(monosubstituted-benzylidene)hydrazino]-1-(hydroxymethyl)-2-oxoethylcarbamate. Lett. Drug Des. Discovery, 9: 257-262.
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102:   Montenegro, R.C., L.V. Lotufo, M.O. Moraes, C.O. Pessoa and F.A.R. Rodrigues et al., 2011. Synthesis and antitumoral evaluation of 7-chloro-4-quinolinylhydrazones derivatives. Med. Chem., 7: 599-604.
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103:   Montenegro, R.C., L.V. Lotufo, M.O. Moraes, C.O. Pessoa and F.A.R. Rodrigues et al., 2012. Cytotoxic activity of polysubstituted 7-chloro-4-quinolinylhydrazone derivatives. Lett. Drug Des. Discovery, 9: 251-256.
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104:   Montenegro, R.C., L.V. Lotufo, M.O. de Moraes, C.O. Pessoa and F.A.R. Rodrigues et al., 2012. 1-(7-Chloroquinolin-4-yl)-2-[(1H-pyrrol-2-yl)methylene]hydrazine: A potent compound against cancer. Med. Chem. Res., 21: 3615-3619.
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105:   Nogueira, T.C.M., M.V.N. de Souza, J.L. Wardell, S.M.S.V. Wardell and E.R.T. Tiekink, 2010. N-(4-Bromophenyl)-2-(2-thienyl)acetamide. Acta Crystallographica, 66: o177-o177.
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106:   Nora de Souza, M.V. and T.R. Alves Vasconcelos, 2006. Recent methodologies mediated by sodium borohydride in the reduction of different classes of compounds. Applied Organometallic Chem., 20: 798-810.
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107:   Peralta, M.A., M.V.N. de Souza, S.M.S.V. Wardell, J.L. Wardell, J.N. Low and C. Glidewell, 2007. 2,3-Dimethoxybenzaldehyde isonicotinoylhydrazone chloroform monosolvate and the mono- and dihydrates of 3,4,5-trimethoxybenzaldehyde isonicotinoylhydrazone: Hydrogen-bonded supramolecular structures in one, two and three dimensions. Acta Crystallogr. Section C, Crystal Struct. Commun., C63: 68-72.
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108:   Pinheiro, A.C., C.R. Kaiser, M.C.S. Lourenco, M.V.N. De Souza, J.L. Wardell and S.M.S.V. Wardell, 2007. Synthesis and in vitro activity towards Mycobacterium tuberculosis of L-serinyl ester and amino derivatives of pyrazinoic acid. J. Chem. Res. Synopses, 3: 180-184.
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109:   Pinheiro, A.C., C.R. Kaiser, T.C.M. Nogueira, S.A. Carvalho and E.F. da Silva et al., 2011. Synthesis and antitubercular activity of new l-serinyl hydrazone derivatives. Med. Chem., 7: 611-623.
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110:   Pinheiro, A.C., M.N. Rocha, P.M. Nogueira, T.C.M. Nogueira, L.F. Jasmim, M.V.N. de Souza and R.P. Soares, 2011. Synthesis, cytotoxicity and in vitro antileishmanial activity of mono-t-butyloxycarbonyl-protected diamines. Diagnostic Microbiol. Infect. Dis., 71: 273-278.
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111:   Pinheiro, A.C., M.V.N. De Souza, E.R.T. Tiekink, S.M.S.V. Wardell and J.L. Wardell, 2011. tert-Butyl N-{(1S)-1-[(2,4-dihydroxybenzylidene)hydrazinecarbonyl]-2-hydroxyethyl}carbamate ethanol monosolvate. Acta Crystallographica Section E Struct. Rep., 67: o581-o582.
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112:   Pinheiro, A.C., M.V.N. de Souza, E.R.T. Tiekink, S.M.S.V. Wardell and J.L. Wardell, 2011. tert-Butyl N-((1S)-2-hydroxy-1-{N'-[(1E)-4-methoxybenzylidene] hydrazinecarbonyl}ethyl)carbamate. Acta Crystallographica, 67: o1805-o1806.
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113:   Pinheiro, A.C., M.V.N. de Souza, J.L. Wardell, S.M.S.V. Wardell and E.R.T. Tiekink, 2011. 1,3-Dicyclohexyl-3-[(pyridin-2-yl)carbonyl]urea monohydrate from synchrotron radiation. Acta Crystallographica, 67: o2676-o2677.
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114:   Porto, B.L.S., M.V.N. De Souza and M.A.L. De Oliveira, 2011. Analysis of omega 3 fatty acid in natural and enriched chicken eggs by capillary zone electrophoresis. Anal. Sci., 27: 541-546.
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115:   Silva Jr, F.P., J. Ellena, M.D.L. Ferreira, Y.P. Mascarenhas and M.V. de Souza et al., 2006. Experimental and theoretical structure characterization of two isoniazid derivatives: 2, 4-Difluoro- N-isonicotinoylbenzohydrazide and 2, 4-dichloro- N-isonicotinoylbenzohydrazide hydrochloride. J. Mol. Struc., 788: 63-71.
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116:   Silva Lourenco, M.C., F. Rodrigues Vicente, M.D. de Oliveira Henriques, A.L. Peixoto Candea and R.S. Borges Goncalves et al., 2007. Synthesis and biological evaluation of N-(aryl)-2-thiophen-2-ylacetamides series as a new class of antitubercular agents. Bioorg. Med. Chem. Lett., 17: 6895-6898.
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117:   Soares, R.P., A.U. Krettli, M.V. de Souza, T.R. Vasconcelos and N. Boechat, 2006. Evaluation of antimalarial and fluoroquinolone combinations against Plasmodium falciparum in vitro. Int. J. Antimicrobial Agents, 28: 271-272.
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118:   Tiekink, E.R.T., M.V.N. de Souza, A.C. Pinheiro, S.M.S.V. Wardell and J.L. Wardell, 2011. Benzyl N-(2-hydroxy-1-{N'-[(1E)-2-hydroxybenzylidene] hydrazinecarbonyl} ethyl)carbamate. Acta Crystallographica, 67: o1866-o1867.
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119:   Varotti, F.P., A.C.C. Botelho, A.A. Andrade, C.R. de Paula and E.M.S. Fagundes et al., 2008. Synthesis, antimalarial activity and intracellular targets of MEFAS, a new hybrid compound derivated from mefloquine and artesunate. Antimicrob. Agents Chemother., 52: 3868-3874.
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120:   Vasconcelos, T.R., M.D. Souza, S.M. Wardell, J.L. Wardell, J.N. Low and C. Glidewell, 2005. Simple chains in methyl 3, 5-dinitrobenzoate, isolated molecules in isopropyl 3, 5-dinitrobenzoate, and a three-dimensional framework containing double and sextuple helices in benzyl 3, 5-dinitrobenzoate, all at 120 K. Acta Crystallographica Sect. C: Crystal Struc. Commun., 62: 26-29.
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121:   Vasconcelos, T.R.A., M.L. Ferreira, R.S.B. Goncalves, E.T. da Silva and M.V.N. de Souza, 2008. Lamivudine, an important drug in aids treatment. J. Sulfur Chem., 29: 559-571.
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122:   Vellasco Jr., W.T., G.P. Guedes, T.R.A. Vasconcelos, M.G.F. Vaz and M.V.N. de Souza et al., 2011. Synthesis and antimalarial activity of thioetherhydroxyethylsulfonamides, potential aspartyl protease inhibitors, Part 3. Eur. J. Med. Chem., 46: 5688-5693.
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123:   Vergara, F.M.F., C.H.L. da Silva, M.G.M.O. Henriques, A.L.P. Candea and M.C.S. Lourenco et al., 2009. Synthesis and antimycobacterial evaluation of N-[(E)-(monosubstituded-benzylidene)]-2-pyrazinecarbohyrazide derivatives. Eur. J. Med. Chem., 44: 4954-4959.
124:   Vergara, F.M.F., M.G.M.O. Henriques, A.L.P. Candea, J.L. Wardell and M.V.N. de Souza, 2009. Antitubercular activity of α,ω-diaminoalkanes, H2N(CH2)nNH2. Bioorg. Med. Chem. Lett., 19: 4937-4938.
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125:   Vinicius Nora De Souza, M., 2006. Stille reaction: An important tool in the synthesis of complex natural products. Curr. Organic Synthesis, 3: 313-326.
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126:   Wardell, J.L., M.V.N. De Souza, S.M.S.V. Wardell and M.C.S. Lourenco, 2011. Mefloquine derivatives: Crystal structures and anti-tubercular activities of diphenyl[((R*,S*)-2,8-bis(trifluoromethyl)quinolin-4-yl)-piperidin-2-yl-methanolato-O,N]boron and (±)-erythro-mefloquinium tetraphenylborate solvates. J. Mol. Struct., 990: 67-74.
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127:   Wardell, J.L., M.V.N. de Souza, A.C. Pinheiro, E.R.T. Tiekink and S.M.S.V. Wardell, 2011. tert-Butyl N-((1S)-2-hydroxy-1-{N'-[(E)-2-hydroxy-4-methoxybenzylidene] hydrazinecarbonyl}ethyl)carbamate. Acta Crystallographica, 67: o1888-o1889.
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128:   Wardell, S.M., L. Ferreira Mde, M.V. de Souza, J.L. Wardell and J.N. Low, 2006. Glidewell C. 2,4-Difluorobenzaldehyde benzoylhydrazone and 2,4-dichlorobenzaldehyde benzoylhydrazone are isostructural at 120 K with Z = 2: Complex sheets built from N-H...O, C-H...O and C-H...pi(arene) hydrogen bonds. Acta Crystallogr C, 62: 118-121.
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129:   Wardell, S.M., M.V. de Souza, J.L. Wardell, J.N. Low and C. Glidewell, 2006. Pyrazine-2-carbohydrazide: A three-dimensional hydrogen-bonded framework structure. Acta Crystallographica Sect. E: Struct. Rep., 62: 3765-3767.
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130:   Wardell, S.M., M.V. de Souza, J.L. Wardell, J.N. Low and C. Glidewell, 2007. Supramolecular structures in N-isonicotinoyl arylaldehydehydrazones: Multiple hydrogen-bonding modes in series of geometric isomers. Acta Crystallogr. Section B, Struct. Sci., B63: 879-895.
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131:   Wardell, S.M., T.R. Vasconcelos, M.V. de Souza, J.L. Wardell, J.N. Low and C. Glidewell, 2006. Four substituted benzohydrazides: Hydrogen-bonded structures in one, two and three dimensions. Acta Crystallogr. Section C, Crystal Struct. Commun., C62: 618-624.
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132:   Wardell, S.M.S.V., E.R.T. Tiekink, M.V.N. de Souza, A.C. Pinheiro and J.L. Wardell, 2011. Benzyl N-(1-{N'-[(E)-2,3-dihydroxybenzylidene]hydrazinecarbonyl}-2-hydroxyethyl)carbamate dihydrate. Acta Crystallographica, 67: o2155-o2156.
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133:   Wardell, S.M.S.V., J.L. Wardell, J.N. Low, C. Glidewell and M.V.N. de Souza, 2007. 3-Nitrobenzaldehyde isonicotinoylhydrazone monohydrate redetermined at 120 K: Sheets built from O-H...O, O-H...N, N-H...O and C-H...O hydrogen bonds. Acta Crystallogr. Section C, Crystal Struct. Commun., C63: 42-44.
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134:   Wardell, S.M.S.V., M.V.N. de Souza, J.L. Wardell, J.N. Low and C. Glidewell, 2006. N-(3,5-Dinitrobenzoyl)-N'-phenylhydrazine: Sheets built from N-H...O and C-H...O hydrogen bonds. Acta Cryst., E62: 2589-2591.
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135:   Wardell, S.M.S.V., M.V.N. de Souza, J.L. Wardell, J.N. Low and C. Glidewell, 2007. Three isomeric 1-(2-chloronicotinoyl)-2-(nitrophenyl)hydrazines, including three polymorphs of 1-(2-chloronicotinoyl)-2-(2-nitrophenyl)hydrazine: hydrogen-bonded supramolecular structures in two and three dimensions. Acta Crystallogr. Section B, Struct. Sci., B63: 101-110.
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136:   Wardell, S.M.S.V., M.V.N. de Souza, T.R.A. Vasconcelos, M.L. Ferreira, J.L. Wardell, J.N. Low and C. Glidewell, 2008. Patterns of hydrogen bonding in mono- and di-substituted N-arylpyrazinecarboxamides. Acta Crystallographica, 64: 84-100.
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