Dr. Marcus Vinicius Nora De Souza

Dr. Marcus Vinicius Nora De Souza

Professor
Institute of Drug Technology Far-Manguinhos, Brazil


Highest Degree
Ph.D. in Organic and Biorganic Chemistry from Universite d`Orsay, France

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Area of Interest:

Chemistry
100%
Organic Chemistry
62%
Medicinal Chemistry
90%
Molecular Structure
75%
Crystallography
55%

Education

1999

Ph.D.

Universite d`Orsay, France

Organic and Biorganic Chemistry

Selected Publications

  1. Montenegro, R.C., L.V. Lotufo, M.O. de Moraes, C.O. Pessoa and F.A.R. Rodrigues et al., 2012. 1-(7-Chloroquinolin-4-yl)-2-[(1H-pyrrol-2-yl)methylene]hydrazine: A potent compound against cancer. Med. Chem. Res., 21: 3615-3619.
    CrossRef  |  Direct Link  |  

  2. Montenegro, R.C., L.V. Lotufo, M.O. Moraes, C.O. Pessoa and F.A.R. Rodrigues et al., 2012. Cytotoxic activity of polysubstituted 7-chloro-4-quinolinylhydrazone derivatives. Lett. Drug Des. Discovery, 9: 251-256.
    CrossRef  |  Direct Link  |  

  3. Montenegro, R.C., L.V. Lotufo, M.O. Moraes, C.O. Pessoa and F.A R. Rodrigues et al., 2012. Synthesis and antitumoral evaluation of benzyl (1S)-2-[2-(monosubstituted-benzylidene)hydrazino]-1-(hydroxymethyl)-2-oxoethylcarbamate. Lett. Drug Des. Discovery, 9: 257-262.
    CrossRef  |  Direct Link  |  

  4. Mazzoccoli, L., S.H. Cadoso, G.W. Amarante, M.V.N. de Souza and R. Domingues et al., 2012. Novel thalidomide analogues from diamines inhibit pro-inflammatory cytokine production and CD80 expression while enhancing IL-10. Biomed. Pharmacother., 66: 323-329.
    CrossRef  |  PubMed  |  Direct Link  |  

  5. Marcellos, L.F., A.F. Faria, M.V.N. de Souza, M.R. Almeida, G.P. Sabin, R.J. Poppi and M.A.L. de Oliveira, 2012. Simultaneous analysis of first-line anti-tuberculosis drugs in tablets by UV spectrophotometry compared to capillary zone electrophoresis. Central Eur. J. Chem., 10: 1808-1816.
    CrossRef  |  Direct Link  |  

  6. Goncalves, R.S.B., C.R. Kaiser, M.C.S. Lourenco, F.A.F.M. Bezerra and M.V.N. De Souza et al., 2012. Mefloquine-oxazolidine derivatives, derived from mefloquine and arenecarbaldehydes: In vitro activity including against the multidrug-resistant tuberculosis strain T113. Bioorg. Med. Chem., 20: 243-248.
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  7. Faria, A.F., J.P. Vasconcelos, R.S.B. Goncalves, M.V.N. de Souza and M.A.L. de Oliveira, 2012. Simultaneous analysis of isoniazid and its impurities by CZE. Chromatographia, 75: 1335-1339.
    CrossRef  |  Direct Link  |  

  8. Facchinetti, V., C.R.B. Gomes, M.V.N. de Souza and T.R.A. 2012. Perspectives on the development of novel potentially active quinolones against tuberculosis and cancer. Mini-Rev. Med. Chem., 12: 866-874.
    CrossRef  |  PubMed  |  

  9. De Souza, M.C., T. Goncalves-Silva, M. Moreth, Claudia R.B. Gomes, C.R. Kaiser, M.G.M.O. Henriques and M.V.N. de Souza, 2012. Synthesis and in vivo antimalarial evaluation of novel hydroxyethylamine derivatives. Med. Chem., 8: 266-272.
    CrossRef  |  PubMed  |  

  10. Da Costa, C.F., A.C. Pinheiro, M.V. de Almeida, M.C.S. Lourenco and M.V.N. de Souza, 2012. Synthesis and antitubercular activity of novel amino acid derivatives. Chem. Biol. Drug Des., 79: 216-222.
    CrossRef  |  PubMed  |  Direct Link  |  

  11. Wardell, S.M.S.V., E.R.T. Tiekink, M.V.N. de Souza, A.C. Pinheiro and J.L. Wardell, 2011. Benzyl N-(1-{N'-[(E)-2,3-dihydroxybenzylidene]hydrazinecarbonyl}-2-hydroxyethyl)carbamate dihydrate. Acta Crystallographica, 67: o2155-o2156.
    CrossRef  |  Direct Link  |  

  12. Wardell, J.L., M.V.N. de Souza, A.C. Pinheiro, E.R.T. Tiekink and S.M.S.V. Wardell, 2011. tert-Butyl N-((1S)-2-hydroxy-1-{N'-[(E)-2-hydroxy-4-methoxybenzylidene] hydrazinecarbonyl}ethyl)carbamate. Acta Crystallographica, 67: o1888-o1889.
    CrossRef  |  Direct Link  |  

  13. Wardell, J.L., M.V.N. De Souza, S.M.S.V. Wardell and M.C.S. Lourenco, 2011. Mefloquine derivatives: Crystal structures and anti-tubercular activities of diphenyl[((R*,S*)-2,8-bis(trifluoromethyl)quinolin-4-yl)-piperidin-2-yl-methanolato-O,N]boron and (±)-erythro-mefloquinium tetraphenylborate solvates. J. Mol. Struct., 990: 67-74.
    CrossRef  |  Direct Link  |  

  14. Vellasco Jr., W.T., G.P. Guedes, T.R.A. Vasconcelos, M.G.F. Vaz and M.V.N. de Souza et al., 2011. Synthesis and antimalarial activity of thioetherhydroxyethylsulfonamides, potential aspartyl protease inhibitors, Part 3. Eur. J. Med. Chem., 46: 5688-5693.
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  15. Tiekink, E.R.T., M.V.N. de Souza, A.C. Pinheiro, S.M.S.V. Wardell and J.L. Wardell, 2011. Benzyl N-(2-hydroxy-1-{N'-[(1E)-2-hydroxybenzylidene] hydrazinecarbonyl} ethyl)carbamate. Acta Crystallographica, 67: o1866-o1867.
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  16. Porto, B.L.S., M.V.N. De Souza and M.A.L. De Oliveira, 2011. Analysis of omega 3 fatty acid in natural and enriched chicken eggs by capillary zone electrophoresis. Anal. Sci., 27: 541-546.
    CrossRef  |  PubMed  |  Direct Link  |  

  17. Pinheiro, A.C., M.V.N. de Souza, J.L. Wardell, S.M.S.V. Wardell and E.R.T. Tiekink, 2011. 1,3-Dicyclohexyl-3-[(pyridin-2-yl)carbonyl]urea monohydrate from synchrotron radiation. Acta Crystallographica, 67: o2676-o2677.
    Direct Link  |  

  18. Pinheiro, A.C., M.V.N. de Souza, E.R.T. Tiekink, S.M.S.V. Wardell and J.L. Wardell, 2011. tert-Butyl N-((1S)-2-hydroxy-1-{N'-[(1E)-4-methoxybenzylidene] hydrazinecarbonyl}ethyl)carbamate. Acta Crystallographica, 67: o1805-o1806.
    Direct Link  |  

  19. Pinheiro, A.C., M.V.N. De Souza, E.R.T. Tiekink, S.M.S.V. Wardell and J.L. Wardell, 2011. tert-Butyl N-{(1S)-1-[(2,4-dihydroxybenzylidene)hydrazinecarbonyl]-2-hydroxyethyl}carbamate ethanol monosolvate. Acta Crystallographica Section E Struct. Rep., 67: o581-o582.
    CrossRef  |  Direct Link  |  

  20. Pinheiro, A.C., M.N. Rocha, P.M. Nogueira, T.C.M. Nogueira, L.F. Jasmim, M.V.N. de Souza and R.P. Soares, 2011. Synthesis, cytotoxicity and in vitro antileishmanial activity of mono-t-butyloxycarbonyl-protected diamines. Diagnostic Microbiol. Infect. Dis., 71: 273-278.
    CrossRef  |  PubMed  |  Direct Link  |  

  21. Pinheiro, A.C., C.R. Kaiser, T.C.M. Nogueira, S.A. Carvalho and E.F. da Silva et al., 2011. Synthesis and antitubercular activity of new l-serinyl hydrazone derivatives. Med. Chem., 7: 611-623.
    CrossRef  |  PubMed  |  

  22. Montenegro, R.C., L.V. Lotufo, M.O. Moraes, C.O. Pessoa and F.A.R. Rodrigues et al., 2011. Synthesis and antitumoral evaluation of 7-chloro-4-quinolinylhydrazones derivatives. Med. Chem., 7: 599-604.
    CrossRef  |  PubMed  |  

  23. Lima, C.H.S., M.G.M.O. Henriques, A.L.P. Candea, M.C.S. Lourenco, F.A.F.M. Bezerra, C.R. Kaiser and M.V.N. De Souza, 2011. Synthesis and antimycobacterial evaluation of N'-(E)-heteroaromaticpyrazine-2-carbohydrazide derivatives. Med. Chem., 7: 245-249.
    CrossRef  |  PubMed  |  

  24. Howie, R.A., M.V.N. De Souza, A.C. Pinheiro, C.R. Kaiser, J.L. Wardell and S.M.S.V. Wardell, 2011. (S)-1-[N-(Benzylidene)hydrazinylcarbonyl]-2-hydroxyethyl carbamate esters: Layered structures created from X-H····O (X= N,O) hydrogen-bonds. Zeitschrift fur Kristallographie, 226: 483-491.

  25. Goncalves, R.S.B., M.V.N. de Souza, S.M.S.V. Wardell, J.L. Wardell and E.R.T. Tiekink, 2011. (R*,S*)-(±)-1-(2-[2,8-Bis(trifluoromethyl)quinolin-4-yl](hydroxy)methylpiperidin-1-yl)ethanone methanol monosolvate. Acta Crystallographica, 67: 2714-2715.

  26. Goncalves, R.S.B., M.V.N. de Souza, J.L. Wardell, S.M.S.V. Wardell and E.R.T. Tiekink, 2011. tert-Butyl 2-{[2,8-bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidine-1-carboxylate. Acta Crystallographica, 67: o3315-o3316.
    CrossRef  |  Direct Link  |  

  27. Goncalves, R.S.B., C.R. Kaiser, M.V.N. de Souza, J.L. Wardell, S.M.S.V. Wardell and R.A. Howie, 2011. Structures of 4-{3-(X-phenyl)perhydro-1,3-oxazolo[3,4-a]pyridin-1-yl}-2,8-bis(trifluoromethyl)quinolines (X = H, 2-O2N, 3-O2N and 4-O2N), derived from mefloquine. Zeitschrift fur Kristallographie, 226: 793-803.
    CrossRef  |  Direct Link  |  

  28. Goncalves, R.S.B., C.R. Kaiser, M.V.N. de Souza, J.L. Wardell, S.M.S.V. Wardell and E.R.T. Tiekink, 2011. 2-{1-[2,8-Bis(trifluoromethyl)quinolin-4-yl]-3,5,6,7,8,8a-hexahydro-1H-1,3-oxazolo[3,4-α]pyridin-3-yl}phenol. Acta Crystallographica, 67: o1656-o1657.
    CrossRef  |  Direct Link  |  

  29. Goncalves, R.S.B., A.C. Pinheiro, E.T. Da Silva, J.C.S. Da Costa, C.R. Kaiser and M.V.N. De Souza, 2011. Simple methodology for the preparation of amino alcohols from amino acid esters using NaBH4-methanol in THF. Synthetic Commun.: Int. J. Rapid Commun. Synthetic Organic Chem., 41: 1276-1281.
    CrossRef  |  Direct Link  |  

  30. Gomes, C.R.B., M. Moreth, D. Cardinot, V. Kopke, W. Cunico, M.C.S. Lourenco and M.V.N. de Souza, 2011. Synthesis and antimycobacterial activity of novel amino alcohols containing central core of the anti-HIV drugs Lopinavir and Ritonavir. Chem. Biol. Drug Des., 78: 1031-1034.
    CrossRef  |  PubMed  |  Direct Link  |  

  31. Faria, A.F., L.F. Marcellos, J.P. Vasconcelos, M.V.N. De Souza and A.L. Silva Jr. et al., 2011. Ethambutol analysis by copper complexation in pharmaceutical formulations: Spectrophotometry and crystal structure. J. Braz. Chem. Soc., 22: 867-874.
    CrossRef  |  Direct Link  |  

  32. De Souza, M.V.N., R.S.B. Goncalves, J.L. Wardell, S.M.S.V. Wardell and E.R.T. Tiekink, 2011. Benzyl 2-{[2,8-bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidine-1-carboxylate. Acta Crystallographica, 67: o3313-o3314.
    Direct Link  |  

  33. De Souza, M.V.N., M.L. Ferreira and L.N.F. Cardoso, 2011. Sodium chlorite (NaClO2): An important reagent in alcohol and aldehyde oxidation and its application in total synthesis of natural products. J. Biol. Active Prod. Nat., 1: 52-80.
    CrossRef  |  Direct Link  |  

  34. De Souza, M.V.N., J.L. Wardell, S.M.S.V. Wardell, S.W. Ng and E.R.T. Tiekink, 2011. 2-{[2,8-Bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-ium 3-amino-5-nitrobenzoate sesquihydrate. Acta Crystallographica, 67: o3019-o3020.
    CrossRef  |  Direct Link  |  

  35. De Souza, M.V.N., C.H.S. Lima, J.L. Wardell, S.M.S.V. Wardell and E.R.T. Tiekink, 2011. N'-[(E)-2-Methoxybenzylidene]pyrazine-2-carbohydrazide. Acta Crystallographica, 67: 1714-1715.
    CrossRef  |  Direct Link  |  

  36. De Souza, M.V.N., A.C. Pinheiro, E.R.T. Tiekink, S.M.S.V. Wardell and J.L. Wardell, 2011. Benzyl N-(1-{N'-[(E)-2-chlorobenzylidene]hydrazinecarbonyl}-2-hydroxyethyl) carbamate. Acta Crystallographica, 67: o1868-o1869.
    CrossRef  |  Direct Link  |  

  37. Cunico, W., C.R.B. Gomes, M.L.G. Ferreira, T.G. Ferreira, D. Cardinot, M.V.N. De Souza and M.C.S. Lourenco, 2011. Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives. Eur. J. Med. Chem., 46: 974-978.
    CrossRef  |  PubMed  |  Direct Link  |  

  38. Coimbra, E.S., A.D. Silva, R.M.P. Dias, R.C.N.R. Corrales, M.L.F. Bispo, C.R. Kaiser and M.V.N. de Souza, 2011. Amodiaquine analogs. Synthesis and anti-leishmanial activity. Mediterranean J. Chem., 3: 106-113.

  39. Castro, A.A., M.V.N. de Souza, N.A. Rey and P.A.M. Farias, 2011. Determination of efavirenz in diluted alkaline electrolyte by cathodic adsorptive stripping voltammetry at the mercury film electrode. J. Braz. Chem. Soc., 22: 1662-1668.
    CrossRef  |  Direct Link  |  

  40. Cardoso, S.H., M.B. Barreto, M.C.S. Lourenco, M.G.M.O. Henriques, A.L.P. Candea, C.R. Kaiser and M.V.N. de Souza, 2011. Antitubercular activity of new coumarins. Chem. Biol. Drug Des., 77: 489-493.
    CrossRef  |  PubMed  |  Direct Link  |  

  41. Nogueira, T.C.M., M.V.N. de Souza, J.L. Wardell, S.M.S.V. Wardell and E.R.T. Tiekink, 2010. N-(4-Bromophenyl)-2-(2-thienyl)acetamide. Acta Crystallographica, 66: o177-o177.
    CrossRef  |  Direct Link  |  

  42. Howie, R.A., R.S. Goncalves, M.V.N. de Souza, E.R.T. Tiekink and J.L. Wardell, 2010. 2-Bromopyridine-3-carboxylic acid. Acta Crystallographica, 66: 486-486.

  43. Howie, R.A., M.V.N. de Souza, S.M.S.V. Wardell, J.L. Wardell and E.R.T. Tiekink, 2010. N'-[(E)-2,6-Dichlorobenzylidene]pyrazine-2-carbohydrazide. Acta Crystallographica, 66: o178-o179.
    CrossRef  |  Direct Link  |  

  44. De Souza, M.V.N., R.A. Howie, E.R.T. Tiekink, J.L. Wardell and S.M.S.V. Wardell, 2010. 7-Chloro-4-[(E)-N'-(4-fluorobenzylidene)hydrazinyl]quinoline monohydrate. Acta Crystallographica, 66: o152-o153.
    CrossRef  |  Direct Link  |  

  45. Da Silva, J.A.F., N.V. de Castro, D.P. de Jesus, A.F. Faria, M.V.N. De Souza and M.A.L. de Oliveira, 2010. Fast determination of ethambutol in pharmaceutical formulations using capillary electrophoresis with capacitively coupled contactless conductivity detection. Electrophoresis, 31: 570-574.
    CrossRef  |  PubMed  |  Direct Link  |  

  46. Carvalho, S.A., E.F. da Silva, M.V.N. de Souza, E.R.T. Tiekink, J.L. Wardell and S.M.S.V. Wardell, 2010. (2E)-N'-Benzoyl-3-(4-nitrophenyl)prop-2-enohydrazide Acta Crystallographica, 66: o150-o151.
    CrossRef  |  Direct Link  |  

  47. Vergara, F.M.F., M.G.M.O. Henriques, A.L.P. Candea, J.L. Wardell and M.V.N. de Souza, 2009. Antitubercular activity of α,ω-diaminoalkanes, H2N(CH2)nNH2. Bioorg. Med. Chem. Lett., 19: 4937-4938.
    CrossRef  |  Direct Link  |  

  48. Vergara, F.M.F., C.H.L. da Silva, M.G.M.O. Henriques, A.L.P. Candea and M.C.S. Lourenco et al., 2009. Synthesis and antimycobacterial evaluation of N-[(E)-(monosubstituded-benzylidene)]-2-pyrazinecarbohyrazide derivatives. Eur. J. Med. Chem., 44: 4954-4959.

  49. Kaiser, C.R., K.C. Pais, M.V.N. de Souza, J.L. Wardell, S.M.S.V. Wardell and E.R.T. Tiekink, 2009. Assessing the persistence of the N-H-N hydrogen bonding leading to supramolecular chains in molecules related to the anti-malarial drug, chloroquine. Cryst. Eng. Commun., 11: 1133-1140.

  50. Howie, A.R., E.R.T. Tiekink, J.L. Wardell, S.M.S.V. Wardell and M.V.N. de Souza, 2009. 7-Chloro-4-[(E)-(3-chlorobenzylidene)hydrazinyl]-14-quinolinium 3-chlorobenzoate. Acta Crystallographica, 65: 3204-3205.

  51. Ferreira, M.L., T.R.A. Vasconcelos, E.M. de Carvalho, M.C.S. Lourenco and S.M.S.V. Wardell et al., 2009. Synthesis and antitubercular activity of novel Schiff bases derived from D-mannitol. Carbohydr. Res., 344: 2042-2047.
    CrossRef  |  PubMed  |  Direct Link  |  

  52. De Souza, M.V.N., K.C. Pais, C.R. Kaiser, M.A. Peralta, M.L. Ferreira and M.C.S. Lourenco, 2009. Synthesis and in vitro antitubercular activity of a series of quinoline derivatives. Bioorg. Med. Chem., 17: 1474-1480.
    CrossRef  |  Direct Link  |  

  53. De Souza, M.V.N., E.R.T. Tiekink, J.L. Wardell and S.M.S.V. Wardelld, 2009. 4-[(2-Chloroethyl)amino]quinolinium chloride monohydrate. Acta Crystallographica, 65: o3120-o3121.
    Direct Link  |  

  54. De Souza, M.V.N., 2009. Promising candidates in clinical trials against multidrug-resistant tuberculosis (MDR-TB) based on natural products. Fitoterapia, 80: 453-460.
    CrossRef  |  Direct Link  |  

  55. De Lima, M.F., M.V.N. de Souza, E.R.T. Tiekink, J.L. Wardell and S.M.S.V. Wardell, 2009. N-(2,6-Dimethylphenyl)-2-(2-thienyl)acetamide. Acta Crystallographica, 65: o3203-o3203.
    CrossRef  |  Direct Link  |  

  56. De Ferreira, M.L., M.V.N. de Souza, R.A. Howie, E.R.T. Tiekink, J.L. Wardell and S.M.S.V. Wardell, 2009. 3-[(E)-(7-Chloro-4-quinolyl)hydrazonomethyl]benzonitrile monohydrate. Acta Crystallographica, 65: o3239-o3240.
    CrossRef  |  Direct Link  |  

  57. Candea, A.L.P., M.L. Ferreira, K.C. Pais, L.N.F. Cardoso and C.R. Kaiser et al., 2009. Synthesis and antitubercular activity of 7-chloro-4-quinolinylhydrazones derivatives. Bioorg. Med. Chem. Lett., 19: 6272-6274.
    CrossRef  |  PubMed  |  Direct Link  |  

  58. Baddeley, T.C., R.A. Howie, C.H.L. da Silva, C.R. Kaiser and M.V.N. de Souza, J.L. Wardell and S.M.S.V. Wardell, 2009. (Pyrazinecarbonyl)hydrazone halobenzaldehydes: Supramolecular arrays generated by face to face stacking of ribbons, formed from C-H-O interactions. Zeitschrift fur Kristallographie, 224: 506-514.

  59. Wardell, S.M.S.V., M.V.N. de Souza, T.R.A. Vasconcelos, M.L. Ferreira, J.L. Wardell, J.N. Low and C. Glidewell, 2008. Patterns of hydrogen bonding in mono- and di-substituted N-arylpyrazinecarboxamides. Acta Crystallographica, 64: 84-100.
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  60. Vasconcelos, T.R.A., M.L. Ferreira, R.S.B. Goncalves, E.T. da Silva and M.V.N. de Souza, 2008. Lamivudine, an important drug in aids treatment. J. Sulfur Chem., 29: 559-571.
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  61. Varotti, F.P., A.C.C. Botelho, A.A. Andrade, C.R. de Paula and E.M.S. Fagundes et al., 2008. Synthesis, antimalarial activity and intracellular targets of MEFAS, a new hybrid compound derivated from mefloquine and artesunate. Antimicrob. Agents Chemother., 52: 3868-3874.
    Direct Link  |  

  62. Lourenco, M.C.S., M.L. Ferreira, M.V.N. de Souza, M.A. Peralta, T.R.A. Vasconcelos and M.G.M.O. Henriques, 2008. Synthesis and anti-mycobacterial activity of (E)-N′-(monosubstituted-benzylidene)isonicotinohydrazide derivatives. Eur. J. Med. Chem., 43: 1344-1347.
    CrossRef  |  PubMed  |  Direct Link  |  

  63. Kaiser, C.R., A.C. Pinheiro, M.V.N. de Souza, S.M.S.V. Wardell and J.L. Wardell, 2008. Formation of N-acyl-N,N/-dicyclohexylureas from DCC and arenecarboxylic acids in the presence of hydroxybenzotriazol in CH2Cl2 at room temperature. J. Chem. Res, 5: 468-472.
    CrossRef  |  Direct Link  |  

  64. Ferreira, M.L., L.N.F. Cardoso, R.S.B. Goncalves, E.T. Silva, M.C.S. Lourenco and M.V.N. de Souza, 2008. Synthesis and antitubercular evaluation of N'-[(E)-(hydroxy, methoxy and ethoxy-substituted-phenyl) Methylidene]isonicotinohydrazide derivatives. Lett. Drug Des. Discovery, 5: 137-140.
    Direct Link  |  

  65. Faria, A.F., M.V.N. de Souza, R.E. Bruns and M.A.L. de Oliveira, 2008. Optimization of an electrolyte system for analysis of ethambutol in pharmaceutical formulations by capillary zone electrophoresis using complexation with copper(II). J. Chromatogr., 1202: 222-228.
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  66. Faria, A.F., M.V.N. de Souza and M.A.L. de Oliveira, 2008. Validation of capillary zone electrophoresis method for the determination of ciprofloxacin, gatifloxacin, moxifloxacin and ofloxacin in pharmaceutical formulation. J. Brazil. Chem. Soc., 19: 389-396.

  67. De Souza, M.V.N., M.L. Ferreira, T.C.M. Nogueira, R.S.B. Goncalves, M.A. Peralta, M.C.S. Lourenco and F.R.C. Vicente, 2008. Synthesis and biological evaluation of N-(Alkyl)-2-thiophen-2-ylacetamides series as a new class of antitubercular agents. Lett. Drug Des. Dis., 5: 221-224.
    CrossRef  |  

  68. De Souza, M.V.N., M.L. Ferreira, A.C. Pinheiro, M.F. Saraiva, M.V. de Almeida and M.S. Valle, 2008. Synthesis and biological aspects of mycolic acids: An important target against Mycobacterium tuberculosis. Scient. World J., 8: 720-751.
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  69. De Souza, M.V.N., M.C.S. Lourenco, M.A. Peralta, R.S.B. Goncalves and T.C.M. Nogueira et al., 2008. Synthesis and biological evaluation of N,N'-di(thiopheneacetyl)diamines series as antitubercular agents. Phosphorus, Sulfur Silicon Relat. Elem., 183: 2990-2997.
    CrossRef  |  

  70. De Souza, M.V.N., 2008. Compounds containing oxazolidinone, triazole and macrolide groups in the treatment of mycobacterial infections. Expert Opin. Ther. Patents, 18: 1101-1105.
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  71. De Pilla Varotti, F., A.C.C. Botelho, A.A. Andrade, R.C. de Paula and E.M.S. Fagundes et al., 2008. Synthesis, antimalarial activity and intracellular targets of MEFAS, a new hybrid compound derived from mefloquine and artesunate. Antimicrob. Agents Chemother., 52: 3868-3874.

  72. Costa, J.C.S., J.S. Neves, M.V.N. de Souza, R.A. Siqueira and N.C. Romeiro et al., 2008. Synthesis and antispasmodic activity of lidocaine derivatives endowed with reduced local anesthetic action. Bioorg. Med. Chem. Lett., 18: 1162-1166.
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  73. Carvalho, S.A., E.F. da Silva, M.V.N. de Souza, M.C.S. Lourenco and F.R.C. Vicente, 2008. Synthesis and antimycobacterial evaluation of new trans-cinnamic acid hydrazide derivatives. Bioorg. Med. Chem. Lett., 18: 538-541.
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  74. Cardoso, S.H., M.V. de Almeida, J.V. Assis, R. Diniz, N.L. Speziali and M.V.N. de Souza, 2008. Synthesis and characterization of n-hydroxyalkyl and oxazolinyl ethionamide derivatives. J. Sulfur Chem., 29: 145-149.
    CrossRef  |  

  75. Wardell, S.M.S.V., M.V.N. de Souza, J.L. Wardell, J.N. Low and C. Glidewell, 2007. Three isomeric 1-(2-chloronicotinoyl)-2-(nitrophenyl)hydrazines, including three polymorphs of 1-(2-chloronicotinoyl)-2-(2-nitrophenyl)hydrazine: hydrogen-bonded supramolecular structures in two and three dimensions. Acta Crystallogr. Section B, Struct. Sci., B63: 101-110.
    Direct Link  |  

  76. Wardell, S.M.S.V., J.L. Wardell, J.N. Low, C. Glidewell and M.V.N. de Souza, 2007. 3-Nitrobenzaldehyde isonicotinoylhydrazone monohydrate redetermined at 120 K: Sheets built from O-H...O, O-H...N, N-H...O and C-H...O hydrogen bonds. Acta Crystallogr. Section C, Crystal Struct. Commun., C63: 42-44.
    CrossRef  |  

  77. Wardell, S.M., M.V. de Souza, J.L. Wardell, J.N. Low and C. Glidewell, 2007. Supramolecular structures in N-isonicotinoyl arylaldehydehydrazones: Multiple hydrogen-bonding modes in series of geometric isomers. Acta Crystallogr. Section B, Struct. Sci., B63: 879-895.
    Direct Link  |  

  78. Silva Lourenco, M.C., F. Rodrigues Vicente, M.D. de Oliveira Henriques, A.L. Peixoto Candea and R.S. Borges Goncalves et al., 2007. Synthesis and biological evaluation of N-(aryl)-2-thiophen-2-ylacetamides series as a new class of antitubercular agents. Bioorg. Med. Chem. Lett., 17: 6895-6898.
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  79. Pinheiro, A.C., C.R. Kaiser, M.C.S. Lourenco, M.V.N. De Souza, J.L. Wardell and S.M.S.V. Wardell, 2007. Synthesis and in vitro activity towards Mycobacterium tuberculosis of L-serinyl ester and amino derivatives of pyrazinoic acid. J. Chem. Res. Synopses, 3: 180-184.
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  80. Peralta, M.A., M.V.N. de Souza, S.M.S.V. Wardell, J.L. Wardell, J.N. Low and C. Glidewell, 2007. 2,3-Dimethoxybenzaldehyde isonicotinoylhydrazone chloroform monosolvate and the mono- and dihydrates of 3,4,5-trimethoxybenzaldehyde isonicotinoylhydrazone: Hydrogen-bonded supramolecular structures in one, two and three dimensions. Acta Crystallogr. Section C, Crystal Struct. Commun., C63: 68-72.
    Direct Link  |  

  81. Lourenco, M.C.S., M.V.N. de Souza, A.C. Pinheiro, M.L. Ferreira, R.S.B. Goncalves, T.C.M. Nogueira and M.A. Peralta, 2007. Evaluation of anti-tubercular activity of nicotinic and isoniazid analogues. Arkivoc, 15: 181-191.
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  82. Lourenco, M.C., I.N. Junior and M.V. de Souza, 2007. In vitro activity of ciprofloxacin, ofloxacin, levofloxacin, sparfloxacin and gatifloxacin against multidrug-resistant Mycobacterium tuberculosis in Rio de Janeiro Brazil. Med. Mal. Infect., 37: 295-298.
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  83. De Souza, M.V.N., S.M.S.V. Wardell, J.L. Wardell, J.N. Low and C. Glidewell, 2007. N-(5-Chloro-2-nitrobenzoyl)-N'-isonicotinoylhydrazine: A three-dimensional framework containing four types of hydrogen bond. Acta Crystallographica. Section E, E63: 230-232.
    CrossRef  |  

  84. De Souza, M.V.N., 2007. Halogen dance reaction and its application in organic synthesis. Curr. Org. Chem., 11: 637-646.
    CrossRef  |  

  85. De Souza, M.V., S.M. Wardell, J.L. Wardell, J.N. Low and C. Glidewell, 2007. 4-Cyanobenzaldehyde isonicotinoylhydrazone monohydrate: A three-dimensional hydrogen-bonded framework structure. Acta Crystallogr. Section C, Crystal Struct. Commun., C63: 166-168.
    Direct Link  |  

  86. De Almeida, M.V., M.F. Saraiva, M.V. de Souza, C.F. da Costa, F.R. Vicente and M.C. Lourenco, 2007. Synthesis and antitubercular activity of lipophilic moxifloxacin and gatifloxacin derivatives. Bioorg. Med. Chem. Lett., 17: 5661-5664.
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  87. Andrade, A.A., F. de Pilla Varotti, I.O. de Freitas, M.V. de Souza, T.R. Vasconcelos, N. Boechat and A.U. Krettli, 2007. Enhanced activity of mefloquine and artesunic acid against Plasmodium falciparum in vitro and P. berghei in mice by combination with ciprofloxacin. Eur. J. Pharmacol., 558: 194-198.
    CrossRef  |  

  88. Almeida, M.V., S.H. Cardoso, J.V. Assis and M.V.N. de Souza, 2007. Synthesis of 2-mercaptobenzothiazole and 2-mercaptobenzimidazole derivatives condensed with carbohydrates as a potential antimicrobial agents. J. Sulfur Chem., 28: 17-22.
    CrossRef  |  

  89. Almeida, M.V., M.V.N. de Souza, N. Barbosa, G.W. Amarante and S.H. Cardoso, 2007. Synthesis and antimicrobial activity of pyridine derivatives substituted at C-2 and C-6 positions. Lett. Drug Des. Dis., 4: 149-153.
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  90. Almeida, M.V., F.M. Teixeira, M.V.N. de Souza, G.W. Amarante and C.C.S. Alves et al., 2007. Thalidomide analogs from diamines: Synthesis and evaluation as inhibitors of TNF-alfa production. Chem. Pharm. Bull., 55: 223-226.

  91. Wardell, S.M.S.V., M.V.N. de Souza, J.L. Wardell, J.N. Low and C. Glidewell, 2006. N-(3,5-Dinitrobenzoyl)-N'-phenylhydrazine: Sheets built from N-H...O and C-H...O hydrogen bonds. Acta Cryst., E62: 2589-2591.
    CrossRef  |  

  92. Wardell, S.M., T.R. Vasconcelos, M.V. de Souza, J.L. Wardell, J.N. Low and C. Glidewell, 2006. Four substituted benzohydrazides: Hydrogen-bonded structures in one, two and three dimensions. Acta Crystallogr. Section C, Crystal Struct. Commun., C62: 618-624.
    Direct Link  |  

  93. Wardell, S.M., M.V. de Souza, J.L. Wardell, J.N. Low and C. Glidewell, 2006. Pyrazine-2-carbohydrazide: A three-dimensional hydrogen-bonded framework structure. Acta Crystallographica Sect. E: Struct. Rep., 62: 3765-3767.
    Direct Link  |  

  94. Wardell, S.M., L. Ferreira Mde, M.V. de Souza, J.L. Wardell and J.N. Low, 2006. Glidewell C. 2,4-Difluorobenzaldehyde benzoylhydrazone and 2,4-dichlorobenzaldehyde benzoylhydrazone are isostructural at 120 K with Z = 2: Complex sheets built from N-H...O, C-H...O and C-H...pi(arene) hydrogen bonds. Acta Crystallogr C, 62: 118-121.
    PubMed  |  Direct Link  |  

  95. Vinicius Nora De Souza, M., 2006. Stille reaction: An important tool in the synthesis of complex natural products. Curr. Organic Synthesis, 3: 313-326.
    CrossRef  |  

  96. Soares, R.P., A.U. Krettli, M.V. de Souza, T.R. Vasconcelos and N. Boechat, 2006. Evaluation of antimalarial and fluoroquinolone combinations against Plasmodium falciparum in vitro. Int. J. Antimicrobial Agents, 28: 271-272.
    PubMed  |  

  97. Silva Jr, F.P., J. Ellena, M.D.L. Ferreira, Y.P. Mascarenhas and M.V. de Souza et al., 2006. Experimental and theoretical structure characterization of two isoniazid derivatives: 2, 4-Difluoro- N-isonicotinoylbenzohydrazide and 2, 4-dichloro- N-isonicotinoylbenzohydrazide hydrochloride. J. Mol. Struc., 788: 63-71.
    CrossRef  |  

  98. Nora de Souza, M.V. and T.R. Alves Vasconcelos, 2006. Recent methodologies mediated by sodium borohydride in the reduction of different classes of compounds. Applied Organometallic Chem., 20: 798-810.
    CrossRef  |  

  99. Low, J.N., S.M. Wardell, M.V. Souza, J.L. Wardell and C. Glidewell, 2006. 2,4-Dimethylbenzaldehyde isonicotinoylhydrazone trihydrate: A three-dimensional hydrogen-bonded framework structure. Acta Crystallogr C, 62: 444-446.
    PubMed  |  Direct Link  |  

  100. Faria, A.F., M.V. de Souza, M.V. de Almeida and M.A. de Oliveira, 2006. Simultaneous separation of five fluoroquinolone antibiotics by capillary zone electrophoresis. Analytica Chimica Acta, 579: 185-192.
    CrossRef  |  

  101. De Souza, M.V.N., T.R. Vasconcelos, M.V. Almeida and S.H. Cardoso, 2006. Fluoroquinolones: An important class of antibiotics against tuberculosis. Curr. Med. Chem., 13: 455-463.
    Direct Link  |  

  102. De Souza, M.V.N., T.A. Vasconcelos, S.M.S.V. Wardell, J.L. Wardell, J.N. Low and C. Glidewell, 2006. Hydrogen-bonded framework structures in 4-[(4-chloro-3-nitrobenzoyl)-hydrazinocarbonyl]pyridiniumchloride and N-3,5-dinitrobenzoyl-N'-isonicotinoylhydrazine. Acta Crystallogr. Section C, Crystal Struct. Commun., C62: 222-226.

  103. De Souza, M.V.N., S.M.S.V. Wardell, J.L. Wardell, T.A. Vasconcelos and E.M. Carvalho, 2006. Comparison of the reactivities of 2-mercaptoaniline and 2-hydroxyaniline with 2-chloronicotinoyl chloride. J. Sulfur Chem., 27: 193-202.
    CrossRef  |  

  104. De Souza, M.V.N., S. Cuffini, S.M.S.V. Wardell, J.L. Wardell, T.A. Vasconcelos, A.G. Oliveira and C. Glidewell, 2006. Nine N-aryl-2-chloronicotinamides: Supramolecular structures in one, two and three dimensions. Acta Crystallogr. Section B, Struct. Sci., B62: 651-665.

  105. De Souza, M.V.N., N. Boechat, J.S. Mendonca, E.L. Fernandes, K.C. Pais, J.C.S. Costa and T.A. Vasconcelos, 2006. Simple reduction of ethyl, isopropyl and benzyl aromatic esters to alcohols using sodium borohydride-methanol system. ARKIVOC, 1: 128-133.

  106. De Souza, M.V.N., J.L. Wardell, S.M.S.V. Wardell, J.N. Low and C. Glidewell, 2006. 5-Chloro-2-nitrobenzaldehyde isonicotinoylhydrazone:a three-dimensional frameworkbuilt from N-H...N and C-H...O hydrogen bonds. Acta Crystallographica Sect. E, 62: 3361-3363.

  107. De Souza, M.V.N., J.L. Wardell, J.N. Low and C. Glidewell, 2006. Pyrrole-2-carbaldehyde isonicotinoylhydrazone monohydrate redetermined at 120K. Acta Crystallographica Sect. C Crystal Struc. Commun., C62: 47-49.

  108. De Souza, M.V.N., I. Neves Junior, G.B.P. Miranda, M.C.S. Lourenco, T.A. Vasconcelos and K.C. Pais, 2006. Synthesis and in vitro anti-tubercular activity of a series of N-(disubstitutedbenzoyl)isoniazid derivatives. Lett. Drug Design Discovery, 3: 424-428.
    CrossRef  |  

  109. De Souza, M.V.N., E.L. Fernandes, K.C. Pais, T.A. Vasconcelos, S.M.S.V. Wardell and J.L. Wardell, 2006. Cyclization studies of 2-chloro-N-(methyl-2-pyridinyl)nicotinamides to methyl 5-oxo-5,6-dihydrodipyrido[1,2-a:3',2'-e]pyrimidin-11-ium chlorides. J. Chem. Res., 2: 93-97.

  110. De Souza, M.V.N., 2006. Marine natural products against tuberculosis. Sci. World J., 6: 847-861.
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  111. De Souza, M.V.N., 2006. Current status and future prospects for new therapies for pulmonary tuberculosis. Curr. Opin. Pulm. Med., 12: 167-171.
    Direct Link  |  

  112. De Souza, M.V., 2006. TEMPO (2, 2, 6, 6-tetramethylpiperidine-N-oxyl) an important reagent in alcohol oxidation and its application in synthesis of natural products. Mini Revi. Organic Chem., 3: 155-165.
    CrossRef  |  

  113. De Souza, M.V., 2006. Promising drugs against tuberculosis. Recent Pat. Antiinfect. Drug Discov., 1: 33-44.
    PubMed  |  

  114. Cunico, W., C.A. Cechinel, H.G. Bonacorso, M.A. Martins and N. Zanatta et al., 2006. Antimalarial activity of 4-(5-trifluoromethyl-1< i> H-pyrazol-1-yl)-chloroquine analogues. Bioorganic Med. Chem. Lett., 16: 649-653.
    PubMed  |  Direct Link  |  

  115. Vasconcelos, T.R., M.D. Souza, S.M. Wardell, J.L. Wardell, J.N. Low and C. Glidewell, 2005. Simple chains in methyl 3, 5-dinitrobenzoate, isolated molecules in isopropyl 3, 5-dinitrobenzoate, and a three-dimensional framework containing double and sextuple helices in benzyl 3, 5-dinitrobenzoate, all at 120 K. Acta Crystallographica Sect. C: Crystal Struc. Commun., 62: 26-29.
    CrossRef  |  

  116. De Souza, M.V.N., T.A. Vasconcelos, S.M.S.V. Wardell, J.L. Wardell, M.L. Ferreira and R.A. Howie, 2005. 8-Methyl-5-oxo-5,6-dihydrodipyrido[1,2-a:3,2-e]-pyrimidin-11-ium chloride trihydrate 120k. Acta Crystall Struc. Sect. E, E61: 3579-3581.
    Direct Link  |  

  117. De Souza, M.V.N., T.A. Vasconcelos, S.M.S. Wardell, J.L. Wardell, J.N. Low and C. Glidewell, 2005. Supramolecular structures of three isomeric 2-chloro-N-(nitrophenyl)nicotinamides. Acta Crystallographica Sect. C Crystal Struc. Commun., 61: 204-208.
    PubMed  |  Direct Link  |  

  118. De Souza, M.V.N., T.A. Vasconcelos, S.C.P. Mello, S.M.S.V. Wardell and M.A. Peralta et al., 2005. Synhtesis and anti-mycobacterial activity of N'[(E)-(disubstituted-phenyl)methylidene]isonicotino-hydrazine derivatives. Lett. Drug Design Discovery, 2: 563-566.
    CrossRef  |  

  119. De Souza, M.V.N., S.M.S.V. Wardell and R.A. Howie, 2005. 2-chloropyridine-3-carboxylic acid. Acta Crystallographica Sect. E, 61: 1347-1349.

  120. De Souza, M.V.N., J.L. Wardell, S.M.S.V. Wardell, M.L. Ferreira, T.A. Vasconcelos, J.N. Low and C. Glidewell, 2005. Pi-Stacked hydrogen-bonded chains of rings in 2,4-difluorobenzaldehyde isonicotinoylhydazone and hydrogen-bonded sheets in 2,3-dichlorobenzaldehyde isonicotinoylhydrazone. Acta Crystallographica Sect. C, 61: 617-620.

  121. De Souza, M.V.N., J.L. Wardell, S.M.S.V. Wardell and J.N. Low, 2005. Four nitrobenzaldehyde isonicotinoylhydrazones at 120K: four different supramolecular strucutures in two and three dimensions. Acta Crystallographica Sect. C Crystal Struc. Commun., 61: 683-689.

  122. De Souza, M.V.N., A.G. Barreto, L.R.M. Estevao, J.R. Biscaia and E.C. Carvalho et al., 2005. Evaluating of the effect of the antimonium pentachloride feed rate to ensure safe conditions for the synthesis of meglumine antimoniate. Ind. Eng. Chem. Res., 44: 6578-6582.

  123. De Souza, M.V.N., 2005. Synthesis and biological activity of natural thiazoles: An important class of heterocyclic compounds. J. Sulfur Chem., 26: 429-449.

  124. De Souza, M.V.N., 2005. Recent synthetic methodologies and your application in synthesis of natural products. Mini Rev. Organic Synthesis, 2: 139-145.

  125. De Souza, M.V.N., 2005. Plants and fungal products with activity against tuberculosis. Scient. World J., 5: 609-628.
    PubMed  |  Direct Link  |  

  126. De Souza, M.V.N., 2005. New fluoroquinolones: A class of potent antibiotics. Mini Rev. Med. Chem., 5: 1009-1017.
    PubMed  |  Direct Link  |  

  127. Boechat, N., J.C.S. da Costa, J.D.S. Mendonca, K.C. Paes and E.L. Fernandes et al., 2005. Simple reduction of heteroaromatic esters to alcohols using a sodium borohydride-methanol system. Synthetic Commun.: Int. J. Rapid Commun. Synthetic Organic Chem., 35: 3187-3190.
    CrossRef  |  

  128. De Souza, M.V.N., S.C.P. Mello, N. Boechat, J.S. Mendonca and J.A. Costa, 2004. Simple reduction of methyl aromatic esters to alcohols using. Tetrahedron Lett., 45: 6021-6022.
    CrossRef  |  

  129. De Souza, M.V.N., R.H. Dodd and H. Zao, 2004. Synthesis of 2,3-dihydrofuro[3,2-c]pyridine-3,4-dicarboxylic acid, a conformationally constrained analogue of the subtype selective NMDA receptor agonist homoquinolinic acid. Heterocycle, 64: 261-275.

  130. De Souza, M.V.N., 2004. Entry inhibitors: A new class of AIDS drugs. Lett. Drugs Discovery Design, 1: 184-193.

  131. De Souza, M.V.N., 2004. (+)-Discodermolide: A marine natural product against cancer. Scient. World, 4: 415-436.
    PubMed  |  Direct Link  |  

  132. De Souza, M.V.N., M.V. Almeida, M.L. Hyaric, E.T. Silva, A.S.M. Almeida and R.M. Santiago, 2003. Synthesis of 2-deoxystreptamine derivatives. J. Carbohydrate Chem., 22: 733-742.

  133. De Almeida, M., L. de Oliviera, E. Cesar and M. de Souza, 2003. Synthesis of platinum complexes from n-benzyl-2-aminoethanethiol derivatives. Scient. World J., 3: 348-353.
    CrossRef  |  

  134. Da Silva, A.D., M.V. De Almeida, M.V. De Souza and M.R. Couri, 2003. Biological activity and synthetic metodologies for the preparation of fluoroquinolones, a class of potent antibacterial agents. Curr. Med. Chem., 10: 21-39.
    CrossRef  |  

  135. Estiarte, M., M.V. de Souza, X. del Rio, R.H. Dodd, M. Rubiralta and A. Diez, 1999. Synthesis and synthetic applications of 3-amino-< i> Δ< sup> 5-piperidein-2-ones: Synthesis of methionine-derived pseudopeptides. Tetrahedron, 55: 10173-10186.
    CrossRef  |  

  136. De Souza, M.V.N. and R.H. Dodd, 1998. Ortho directed lithiation studies of 4-chloropicolinanilide: Introduction of functional groups at c-3 and their elaboration to chain extended derivatives via carbon-carbon bond formation. Heterocycles, 47: 811-827.
    CrossRef  |