Dr. Fatima Regina Mena Barreto Silva

Dr. Fatima Regina Mena Barreto Silva

Associate Professor
Federal University of Santa Catarina, Brazil


Highest Degree
Ph.D. in Biochemistry from Federal University of Rio Grande do Sul, Brazil

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Area of Interest:

Chemistry
100%
Diabetes
62%
Thyroid Hormones
90%
Biochemistry
75%
Medicinal Chemistry
55%

Education

1995

Ph.D.

Federal University of Rio Grande do Sul, Brazil

Biochemistry

Selected Publications

  1. Zanatta, A.P., L. Zanatta, R. Goncalves, A. Zamoner and F.R.M.B. Silva, 2013. Rapid responses to reverse T3 hormone in immature rat sertoli cells: Calcium uptake and exocytosis mediated by integrin. PLoS ONE, Vol. 8. 10.1371/journal.pone.0077176.
    CrossRef  |  Direct Link  |  

  2. Zanatta, A.P., L. Zanatta, R. Goncalves, A. Zamoner and F.R.M.B. Silva, 2013. Integrin participates in the effect of thyroxine on plasma membrane in immature rat testis. Biochim. Biophys. Acta General Subjects, 1830: 2629-2637.
    CrossRef  |  PubMed  |  Direct Link  |  

  3. Silva, F.R.M.B., L. Zanatta, R.C. Pedrosa and M.Z. Fang, 2013. Steroids and related compounds: Basic and clinical aspects. BioMed Res. Int., Vol. 2013. 10.1155/2013/703476.
    CrossRef  |  Direct Link  |  

  4. Silva, F.R.M.B. and L.H. Cazarolli, 2013. Hot topic: Synthetic, natural and related compounds: New approach to chronic diseases studies. Curr. Topics Med. Chem., 12: 2035-2036.
    Direct Link  |  

  5. Liz, R., L. Zanatta, G.O. dos Reis, H. Horst, M.G. Pizzolatti , F.R.M.B. Silva and T.S. Frode, 2013. Acute effect of β-sitosterol on calcium uptake mediates anti-inflammatory effect in murine activated neutrophils. J. Pharm. Pharmacol., 65: 115-122.
    CrossRef  |  PubMed  |  Direct Link  |  

  6. Kappel, V.D., M.J.S. Frederico, B.G. Postal, C.P. Mendes, L.H. Cazarolli and F.R.M.B. Silva, 2013. The role of calcium in intracellular pathways of rutin in rat pancreatic islets: Potential insulin secretagogue effect. Eur. J. Pharmacol., 702: 264-268.
    CrossRef  |  PubMed  |  Direct Link  |  

  7. Kappel, V.D., L.H. Cazarolli, D.P. Fontana, B.G. Postal and F.A. Madoglio et al., 2013. Beneficial effects of banana leaves (Musa x paradisiacal) on glucose homeostasis: Multiple sites of action. Rev. Bras. Farmacognosia, Vol. 23. (In Press). 10.1590/S0102-695X2013005000062.
    CrossRef  |  Direct Link  |  

  8. Kappel, V.D., L.H. Cazarolli, D.F. Pereira, B.G. Postal, A. Zamoner, F.H. Reginatto and F.R.M.B. Silva, 2013. Involvement of GLUT-4 in the stimulatory effect of rutin on glucose uptake in rat soleus muscle. J. Pharm. Pharmacol., 65: 1179-1186.
    CrossRef  |  PubMed  |  Direct Link  |  

  9. Kappel, V.D., L. Zanatta, B.G. Postal and F.R.M.B. Silva, 2013. Rutin potentiates calcium uptake via voltage-dependent calcium channel associated with stimulation of glucose uptake in skeletal muscle. Arch. Biochem. Biophys., 532: 55-60.
    CrossRef  |  PubMed  |  Direct Link  |  

  10. Cazarolli, L.H., D.F. Pereira, V.D. Kappel, P. Folador, S. Figueiredo Mdos, M.G. Pizzolatti and F.R. Silva, 2013. Insulin signaling: A potential signaling pathway for the stimulatory effect of kaempferitrin on glucose uptake in skeletal muscle. Eur. J. Pharmacol., 712: 1-7.
    CrossRef  |  

  11. Cavalli, V.L.L.O., D. Cattani, C.E.H. Rieg, L. Zanatta and P. Pierozan et al., 2013. Roundup disrupts male reproductive functions by triggering calcium-mediated cell death in rat testis and Sertoli cells. Free Radical Biol. Med., 65: 335-346.
    CrossRef  |  PubMed  |  Direct Link  |  

  12. Zanatta, L., P.B. Goulart, R. Goncalves, P. Pierozan and E.C. Winkelmann-Duarte et al., 2012. 1α,25-Dihydroxyvitamin D3 mechanism of action: Modulation of L-type calcium channels leading to calcium uptake and intermediate filament phosphorylation in cerebral cortex of young rats. Biochim. Biophys. Acta Mol. Cell Res., 1823: 1708-1719.
    CrossRef  |  PubMed  |  Direct Link  |  

  13. Rosso, A., M. Pansera, A. Zamoner, L. Zanatta, H. Bouraima-Lelong, S. Carreau and F.R.M.B. Silva, 2012. 1α,25(OH)2-vitamin D3 stimulates rapid plasma membrane calcium influx via MAPK activation in immature rat Sertoli cells. Biochimie, 94: 146-154.
    CrossRef  |  PubMed  |  Direct Link  |  

  14. Pereira, D.F., V.D. Kappel, L.H. Cazarolli, A.A. Boligon and M.L. Athayde et al., 2012. Influence of the traditional Brazilian drink Ilex paraguariensis tea on glucose homeostasis. Phytomedicine, 19: 868-877.
    CrossRef  |  PubMed  |  Direct Link  |  

  15. Kappel, V.D., D.F. Pereira, L.H. Cazarolli, S.M. Guesser and C.H.B. da Silva et al., 2012. Short and long-term effects of Baccharis articulate on glucose homeostasis. Molecules, 17: 6754-6768.
    CrossRef  |  PubMed  |  Direct Link  |  

  16. Frederico, M.J.S., A.J.G. Castro, A. Mascarello, C.P. Mendes and V.D. Kappel et al., 2012. Acylhydrazones contribute to serum glucose homeostasis through dual physiological targets. Curr. Topics Med. Chem., 12: 2049-2058.
    CrossRef  |  PubMed  |  

  17. Cazarolli, L.H., V.D. Kappel, D.F. Pereira, H.H. Moresco, I.M.C. Brighente, M.G. Pizzolatti and F.R.M.B. Silva, 2012. Acute antihyperglycemic role of crude extract, fractions and flavonoids from Averrhoa carambola. Fitoterapia, 83: 1176-1183.

  18. Zanatta, L., H. Bouraima, D.L. Christelle, F.R.M.B. Silva and S. Carreau, 2011. Regulation of aromatase expression by 1,25(OH)2 vitamin D3 in rat testicular cells. Reprod. Fertility Dev., 23: 725-735.
    CrossRef  |  Direct Link  |  

  19. Zanatta, L., A. Zamoner, R. Goncalves, A.P. Zanatta, H. Bouraima-Lelong, S. Carreau and F.R.M.B. Silva, 2011. 1α,25-dihydroxyvitamin D3 signaling pathways on calcium uptake in 30-day-old rat sertoli cells. Biochemistry, 50: 10284-10292.
    CrossRef  |  PubMed  |  Direct Link  |  

  20. Zanatta, L., A. Zamoner, R. Goncalves, A.P. Zanatta and H. Bouraima-Lelong et al., 2011. Effect of 1α,25-dihydroxyvitamin D3 in plasma membrane targets in immature rat testis: Ionic channels and gamma-glutamyl transpeptidase activity. Arch. Biochem. Biophy., 515: 46-53.
    CrossRef  |  Direct Link  |  

  21. Zanatta, L., A. Zamoner, A.P. Zanatta, H. Bouraima-Lelong and C. Delalande et al., 2011. Nongenomic and genomic effects of 1α,25(OH)2 vitamin D3 in rat testis. Life Sci., 89: 515-523.
    CrossRef  |  PubMed  |  Direct Link  |  

  22. Zamoner, A., R. Pessoa-Pureur and F.R.M.B. Silva, 2011. Membrane-initiated actions of thyroid hormones on the male reproductive system. Life Sci., 89: 507-514.
    CrossRef  |  PubMed  |  Direct Link  |  

  23. Silva, F R.M.B., A.Z.P. de Souza and S. Carreau, 2011. International symposium on cell signaling. Life Sci., 89: 505-506.

  24. Pereira, D.F., L.H. Cazarolli, C. Lavado, V. Mengatto and M.S. Figueiredo et al., 2011. Effects of flavonoids on α-glucosidase activity: Potential targets for glucose homeostasis. Nutrition, 27: 1161-1167.
    CrossRef  |  

  25. Carreau, S., H. Bouraima-Lelong, C. Boism, L. Zanatta, F.R.M.B. Silva and C. Delalande, 2011. Aromatase, estrogens and testicular germ cell development. Immunol. Endocrine Metab. Agents Med. Chem., 11: 33-39.
    CrossRef  |  Direct Link  |  

  26. Carreau, S., C. Bois, L. Zanatta, F.R.M.B. Silva, H. Bouraima-Lelong and C. Delalande, 2011. Estrogen signaling in testicular cells. Life Sci., 89: 584-587.
    CrossRef  |  Direct Link  |  

  27. Suzuki, D.O.H., A. Ramos, M.C.M. Ribeiro, L.H. Cazarolli, F.R. Silva, L.D. Leite and J.L.B. Marques, 2010. Theoretical and experimental analysis of electroporated. IEEE Trans. Biomed. Eng., 99: 1-7.

  28. Menegaz, D., C. Royer, A. Rosso, A.Z.P. de Souza, A.R.S. dos Santos and F.R.M.B. Silva, 2010. Rapid stimulatory effect of thyroxine on plasma membrane transport systems: Calcium uptake and neutral amino acid accumulation in immature rat testis. Int. J. Biochem. Cell Biol., 42: 1046-1051.
    CrossRef  |  Direct Link  |  

  29. Menegaz, D., A. Barrientos-Duran, A. Kline, F.R.M.B. Silva, A.W. Norman, M.T. Mizwicki and L.P. Zanello, 2010. 1α,25(OH)2-Vitamin D3 stimulation of secretion via chloride channel activation in Sertoli cells. J. Steroid Biochem. Mol. Biol., 119: 127-134.
    CrossRef  |  Direct Link  |  

  30. Folador, P., L.H. Cazarolli, A.C. Gazola, F.He. Reginatto, E.P. Schenkel and F.R.M.B. Silva, 2010. Potential insulin secretagogue effects of isovitexin and swertisin isolated from Wilbrandia ebracteata roots in non-diabetic rats. Fitoterapia, 81: 1180-1187.
    CrossRef  |  Direct Link  |  

  31. Damazio, R.G., A.P. Zanatta, L.H. Cazarolli, L.D. Chiaradia and A. Mascarello et al., 2010. Antihyperglycemic activity of naphthylchalcones. Eur. J. Med. Chem., 45: 1332-1337.
    CrossRef  |  

  32. Menegaz, D., A. Rosso, C. Royer, L.D. Leite, A.R.S. Santos and F.R.M.B. Silva, 2009. Role of 1α,25(OH)2 vitamin D3 on α-[1-14C]MeAIB accumulation in immature rat testis. Steroids, 74: 264-269.
    CrossRef  |  PubMed  |  Direct Link  |  

  33. Damazio, R.G., A.P. Zanatta, L.H. Cazarolli, A. Mascarello and L.D. Chiaradia et al., 2009. Nitrochalcones: Potential in vivo insulin secretagogues. Biochimie, 91: 1493-1498.
    CrossRef  |  Direct Link  |  

  34. Cazarolli, L.H., P. Folador, H.H. Moresco, I.M.C. Brighente, M.G. Pizzolatti and F.R.M.B. Silva, 2009. Stimulatory effect of apigenin-6-β-L-fucopyranoside on insulin secretion and glycogen synthesis. Eur. J. Med. Chem., 44: 4668-4673.

  35. Cazarolli, L.H., P. Folador, H.H. Moresco, I.M.C. Brighente, M.G. Pizzolatti and F.R.M.B. Silva, 2009. Mechanism of action of the stimulatory effect of apigenin-6-C-(2"-O-alpha-L-rhamnopyranosyl)-B-L-fucopyranoside on 14C-glucose uptake. Chem. Biol. Interact., 179: 407-412.

  36. Zanatta, L., A. Rosso, P. Folador, M.S.R.B. Figueiredo, M.G. Pizzolatti, L.D. Leite and F.R.M.B. Silva, 2008. Insulinomimetic effect of kaempferol 3-neohesperidoside on the rat soleus muscle. J. Nat. Prod., 71: 532-535.
    CrossRef  |  PubMed  |  Direct Link  |  

  37. Zamoner, A., L. Heimfarth, S.O. Loureiro, C. Royer, F.R.M.B. Silva and R.P. Pureur, 2008. Nongenomic actions of thyroxine modulate intermediate filament phosphorylation in cerebral cortex of rats. Neuroscience, 156: 640-652.
    CrossRef  |  PubMed  |  Direct Link  |  

  38. Zamoner, A., K.P. Barreto, D.W. Filho, F. Sell and V.M. Woehl et al., 2008. Propylthiouracil-induced congenital hypothyroidism upregulates vimentin phosphorylation and depletes antioxidant defences in immature rat testis. J. Mol. Endocrinol., 40: 125-135.

  39. Cazarolli, L.H., L. Zanatta, E.H. Alberton, M.S.R.B. Figueiredo and P. Folador et al., 2008. Flavonoids: Prospective drug candidates. Mini-Rev. Med. Chem., 13: 1429-1440.
    CrossRef  |  PubMed  |  Direct Link  |  

  40. Cazarolli, L.H., L. Zanatta, E.H. Alberton, M.S.R.B. Figueiredo and P. Folador et al., 2008. Flavonoids: Cellular and molecular mechanism of action in glucose homeostasis. Mini-Rev. Med. Chem., 8: 1032-1038.
    CrossRef  |  PubMed  |  Direct Link  |  

  41. Alberton, E.H., R.G. Damazio, L.H. Cazarolli, L.D. Chiaradia and P.C. Leal et al., 2008. Influence of chalcone analogues on serum glucose levels in hyperglycemic rats. Chem. Biol. Interact., 171: 355-362.
    CrossRef  |  PubMed  |  Direct Link  |  

  42. Zanatta, L., E. de Sousa, L.H. Cazarolli, A. Cunha Jr., A.M.G. Pizzolatti, B. Szpoganicz and F.R.M.B. Silva, 2007. Effect of crude extract and fractions from Vitex megapotamica leaves on hyperglycemia in alloxan-diabetic rats. J. Ethnopharmacol., 109: 151-155.
    Direct Link  |  

  43. Zamoner, A., K.P. Barreto, D.W. Filho, F. Sell and V.M. Woehl et al., 2007. Hyperthyroidism in the developing rat testis is associated with oxidative stress and hyperphosphorylated vimentin accumulation. Mol. Cell. Endocrinol., 267: 116-126.
    CrossRef  |  PubMed  |  Direct Link  |  

  44. Zamoner, A., C. Royer, K.P. Barreto, R. Pessoa-Pureur and F.R.M.B. Silva, 2007. Ionic involvement and kinase activity on the mechanism of nongenomic action of thyroid hormones on 45Ca2+ uptake in cerebral cortex from young rats. Neurosci. Res., 57: 98-103.
    CrossRef  |  Direct Link  |  

  45. Zamoner, A., C. Funchal, M.C. Jacques-Silva, C. Gottfried, F.R.M.B. Silva and R.P. Pureur, 2007. Thyroid hormones reorganize the cytoskeleton of glial cells through GFAP phosphorylation and RHOA-dependent mechanisms. Cell. Mol. Neurobiol., 27: 845-865.
    CrossRef  |  PubMed  |  Direct Link  |  

  46. Sand, C.V., T.O. Vieira, T.B. Oliveira, D.W. Filho, F.R.M.B. Silva and T.B. Pasa, 2007. Influence of oral glutamine and glucose on markers of oxidative stress in a paraquat rat model. Eur. e-J. Clin. Nutr. Metab., 2: 63-67.
    CrossRef  |  Direct Link  |  

  47. Palodeto, V., D.O.H. Suzuki, E.V. Garcia, C. Royer, L.D. Leite, F.R.M.B. Silva and J.L.B. Marques, 2007. Restoration of transmembrane potential using morphological operators and adaptive alpha-trimmed mean filtering. IFMBE Proc., 14: 1238-1240.
    CrossRef  |  Direct Link  |  

  48. Guiotoku, M., F.R.M.B. Silva, J.C. Azzolini, A.L.R. Merce, A.S. Mangrich, L.F. Sala and B. Szpoganicz, 2007. Monosaccharides and the VO(IV) metal ion: Equilibrium, thermal studies and hypoglycemic effect. Polyhedron, 26: 1269-1276.
    CrossRef  |  Direct Link  |  

  49. Zamoner, A., C. Funchal, L. Heimfarth, F.R.M.B. Silva and R.P. Pureur, 2006. Short-term effects of thyroid hormones on cytoskeletal proteins are mediated by gabaergic mechanisms in slices of cerebral cortex from young rats. Cell. Mol. Neurobiol., 26: 209-224.
    CrossRef  |  PubMed  |  Direct Link  |  

  50. Zamoner, A., A.N. Bruno, E.A. Casali, P.F. Corbelini and G.P. Diniz et al., 2006. Genomic-independent action of thyroid hormones on NTPDase activities in Sertoli cell cultures from congenital hypothyroid rats. Life Sci., 80: 51-58.
    CrossRef  |  PubMed  |  Direct Link  |  

  51. Menegaz, D., A. Zamoner, C. Royer, L.D. Leite, Z.A. Bortolotto and F.R.M.B. Silva, 2006. Rapid responses to thyroxine in the testis: Active protein synthesis-independent pathway. Mol. Cell. Endocrinol., 246: 128-134.
    CrossRef  |  PubMed  |  Direct Link  |  

  52. Cazarolli, L.H., L. Zanatta, A.P. Jorge, E. de Sousa and H. Horst et al., 2006. Follow-up studies on glycosylated flavonoids and their complexes with vanadium: their anti-hyperglycemic potential role in diabetes. Chem. Biol. Interact., 163: 177-191.
    CrossRef  |  PubMed  |  Direct Link  |  

  53. Zamoner, A., P.F. Corbelini, C. Funchal, D. Menegaz, F.R.M.B. Silva and R. Pessoa-Pureur, 2005. Involvement of calcium-dependent mechanisms in T3-induced phosphorylation of vimentin of immature rat testis. Life Sci., 77: 3321-3335.
    CrossRef  |  PubMed  |  Direct Link  |  

  54. Volpato, K.C., D. Menegaz, L.D. Leite, K.P. Barreto, E.V. Garcia and F.R.M.B. Silva, 2004. Involvement of K+channels and calcium-dependent pathways in the action of T3 on amino acid accumulation and membrane potential in Sertoli cells of immature rat testis. Life Sci., 74: 1277-1288.
    CrossRef  |  PubMed  |  Direct Link  |  

  55. Jorge, A.P., H. Horst, E. de Sousa, M.G. Pizzolatti and F.R.M.B. Silva, 2004. Insulinomimetic effects of kaempferitrin on glycaemia and on 14C-glucose uptake in rat soleus muscle. Chem. Biol. Interact., 149: 89-96.
    CrossRef  |  PubMed  |  Direct Link  |  

  56. De Sousa, E., L. Zanatta, I. Seifriz, T.B. Creczynski-Pasa, M.G. Pizzolatti, B. Szpoganicz and F.R.M.B. Silva, 2004. Hypoglycemic effect and antioxidant potential of kaempferol-3,7-O-(α)-dirhamnoside from Bauhinia forcata leaves. J. Nat. Prod., 67: 829-832.
    CrossRef  |  Direct Link  |  

  57. Silva, F.R.M.B., L.D. Leite and G.F. Wassermann, 2002. Rapid signal transduction in sertoli cells. Eur. J. Endocrinol., 147: 425-433.
    CrossRef  |  PubMed  |  Direct Link  |  

  58. Silva, F.R.M.B., B. Szpoganicz, M.G. Pizzolatti, M.A. Willrich and E. de Sousa, 2002. Acute effect of Bauhinia forficata on serum glucose levels in normal and alloxan-induced diabetic rats. J. Ethnopharmacol., 83: 33-37.
    CrossRef  |  

  59. Norman, A.W., C.J. Olivera, F.R.M.B. Silva and J.E. Bishop, 2002. A specific binding protein/receptor for 1α,25-dihydroxyvitamin D3 is present in an intestinal caveolae membrane fraction. Biochem. Biophys. Res. Commun., 298: 414-419.
    CrossRef  |  PubMed  |  Direct Link  |  

  60. Silva, F.R.M.B., L.D. Leite, K.P. Barreto, C. D'Agostini and A. Zamoner, 2001. Effect of 3,5,3′-triiodo-L-thyronine on amino acid accumulation and membrane potential in Sertoli cells of the rat testis. Life Sci., 69: 977-986.
    CrossRef  |  PubMed  |  Direct Link  |  

  61. Norman, A.W. and F.R.M.B. Silva, 2001. Structure function studies: Identification of vitamin D analogs for the ligand-binding domains of important proteins in the vitamin D-endocrine system. Rev. Endocrine Metab. Disorders, 2: 229-238.
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