Hi, I am Juan Francisco Santibanez Dominguez, My LiveDNA is 56.5989
 
   
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Dr. Juan Francisco Santibanez Dominguez
 
Highest Degree: Ph.D. in Biological Sciences from Autonoma University of Madrid, Spain
 
Institute: University of Belgrade, Serbia
 
Area of Interest: Molecular Sciences
  •   Tumor Progression
  •   Urokinase
  •   Metalloproteinases
  •   Cell Migration
 
URL: http://livedna.org/56.5989
 
My SELECTED Publications
1:   Blanco, F.J., J.F. Santibanez, M. Guerrero-Esteo, C. Langa, C.P. Vary and C. Bernabeu, 2005. Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-β receptor complex. J. Cell Physiol., 204: 574-584.
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2:   Cokic, V. and J.F. Santibanez, 2013. Janus Kinase 2 and Transforming Growth Factor Beta Signal Transduction Targeted Therapies in Myeloproliferative Neoplasms. In: Frontiers in Anti-Cancer Drug Discovery. Atta-Ur-Rahman, F.R.S. and M.I. Choudhary (Eds.). Bentham Science Publishers, Sharjah, UAE., ISBN-13: 9781608051618, Pages: 779.
3:   Depix, M.S., J. Martinez, F. Santibanez, J. Rovirosa, A. San Martin and R.B. Maccioni, 1998. The compound 14-keto-stypodiol diacetate from the algae Stypopodium flabelliforme inhibits microtubules and cell proliferation in DU-145 human prostatic cells. Mol. Cell. Biochem., 187: 191-199.
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4:   Echeverria, C., J.F. Santibanez, O. Donoso-Tauda, C.A. Escobar and R. Ramirez-Tagle, 2009. Structural antitumoral activity relationships of synthetic chalcones. Int. J. Mol. Sci., 10: 221-231.
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5:   Eisner, V., A. Criollo, C. Quiroga, C. Olea-Azar and J.F. Santibanez et al., 2006. Hyperosmotic stress-dependent NFκB activation is regulated by reactive oxygen species and IGF-1 in cultured cardiomyocytes. FEBS Lett., 580: 4495-4500.
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6:   Guerrero, J., J.F. Santibanez, A. Gonzalez and J. Martinez, 2004. EGF receptor transactivation by urokinase receptor stimulus through a mechanism involving Src and matrix metalloproteinases. Exp. Cell Res., 292: 201-208.
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7:   Jerkic, M., J.V. Rivas-Elena, J.F. Santibanez, M. Prieto and A. Rodriguez-Barbero et al., 2006. Endoglin regulates cyclooxygenase-2 expression and activity. Circulat. Res., 99: 248-256.
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8:   Juretic, N., J.F. Santibanez, C. Hurtado and J. Martinez, 2001. ERK 1,2 and p38 pathways are involved in the proliferative stimuli mediated by urokinase in osteoblastic SaOS-2 cell line. J. Cell Biochem., 83: 92-98.
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9:   Kocic, J., D. Bugarski and J.F. Santibanez, 2012. SMAD3 is essential for transforming growth factor-β1-induced urokinase type plasminogen activator expression and migration in transformed keratinocytes. Eur. J. Cancer, 48: 1550-1557.
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10:   Kocic, J., J.F. Santibanez, A. Krstic, S. Mojsilovic and I.O. Dordevic et al., 2012. Interleukin 17 inhibits myogenic and promotes osteogenic differentiation of C2C12 myoblasts by activating ERK1,2. Biochim. Biophys. Acta, Mol. Cell. Res., 1823: 838-849.
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11:   Kocic, J., J.F. Santibanez, A. Krstic, S. Mojsilovic, V. Ilic and D. Bugarski, 2013. Interleukin-17 modulates myoblast cell migration by inhibiting urokinase type plasminogen activator expression through p38 mitogen-activated protein kinase. The Int. J. Biochem. Cell Biol., 45: 464-475.
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12:   Kocic, J., V. Villar, A. Krstic and J.F. Santibanez, 2012. SKIP downregulation increases TGF-β1-induced Matrix Metalloproteinase-9 production in transformed keratinocytes. Scientifica. 10.6064/2012/861647.
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13:   Krstic, A., J. Kocic, V. Ilic, S. Mojsilovic and I. Okic-Dordevic et al., 2012. Effects of IL-17 on erythroid progenitors growth: involvement of MAPKs and GATA transcription factors. J. Biol. Regul. Homeost. Agents, 26: 641-652.
PubMed  |  
14:   Krstic, A., J.F. Santibanez, I. Okic, S. Mojsilovic and J. Kocic et al., 2010. Combined effect of IL-17 and blockade of nitric oxide biosynthesis on haematopoiesis in mice. Acta Physiol., 199: 31-41.
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15:   Krstic, J. and J.F. Santibanez, 2013. Transforming growth factor-beta and matrix metalloproteinases functional interplay in cancer; implications in epithelial to mesenchymal transition. Cell Biol.: Res. Therapy .
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16:   Krstic, J. and J.F. Santibanez, 2013. Transforming growth factor-beta and matrix metalloproteinases: Functional interactions in tumor stroma-infiltrating myeloid cells. Scientific World J 10.1155/2014/521754.
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17:   Krstic, J., A. Jaukovic, S. Mojsilovic, I.O. Dordevic and D. Trivanovic et al., 2013. In vitro effects of IL-17 on angiogenic properties of endothelial cells in relation to oxygen levels. Cell Biol. Int., 37: 1162-1170.
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18:   Krstic, J., H. Obradovic, A. Jaukovic, I. Okic-Dordevic and D. Trivanovic et al., 2015. Urokinase type plasminogen activator mediates interleukin-17-induced peripheral blood mesenchymal stem cell motility and transendothelial migration. Biochimica Biophysica Acta (BBA)-Mol. Cell Res., 1853: 431-444.
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19:   Krstic, J., I. Maslovaric and J.F. Santibanez, 2014. Novel patents and cancer therapies for transforming growth factor-beta and urokinase type plasminogen activator: Potential use of their interplay in tumorigenesis. Recent Patents Anti-Cancer Drug Discovery, 9: 354-371.
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20:   Krstic, M., S.P. Sovilj, S. Grguric-Sipka, I.R. Evans and S. Borozan et al., 2010. New ruthenium(II) complexes with N-alkylphenothiazines: Synthesis, structure, in vivo activity as free radical scavengers and in vitro cytotoxicity. Eur. J. Med. Chem., 45: 3669-3676.
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21:   Krstic, M., S.P. Sovilj, S. Grguric-Sipka, I.R. Evans and S. Borozan et al., 2011. Synthesis, structural and spectroscopic characterization, in vitro cytotoxicity and in vivo activity as free radical scavengers of chlorido(p-cymene) complexes of ruthenium(II) containing N-alkylphenothiazines. Eur. J. Med. Chem., 46: 4168-4177.
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22:   Lavandero, S., J.F. Santibanez, M.P. Ocaranza and M. Sapag-Hagar, 1990. Insulin-like growth factor I receptor levels during the lactogenic cycle in rat mammary gland. Biochem. Soc. Trans., 18: 576-577.
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23:   Lavandero, S., J.F. Santibanez, M.P. Ocaranza, A. Ferreira and M. Sapag-Hagar, 1991. Binding and production of insulin-like growth factor-I in rat mammary gland. Comp. Biochem. Physiol. Part A. Physiol., 99: 507-511.
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24:   Martinez, J. and J.F. Santibanez, 1993. Extracellular calcium modulates proliferation of factor dependent hemopoietic cells. Cell. Biochem. Funct., 11: 101-105.
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25:   Martinez, J. and J.F. Santibanez, 1994. Surface-associated plasminogen activation in leukemic cells: Interaction with extracellular matrix. Eur. J. Cell. Biol., 64: 257-263.
PubMed  |  
26:   Martinez, J., J.F. Santibanez, C. Vial and R.B. Maccioni, 1992. The antineoplastic agent estramustine and the derivative estramustine-phosphate inhibit secretion of interleukin-3 in leukemic cells. Possible roles of MAPs. Mol. Cell. Biochem., 117: 165-173.
PubMed  |  
27:   Martinez, J., M. Fuentes, V. Cambiazo and J.F. Santibanez, 1999. Bone extracellular matrix stimulates invasiveness of estrogen-responsive human mammary MCF-7 cells. Int. J. Cancer, 83: 278-282.
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28:   Martinez, J., S. Silva and J.F. Santibanez, 1996. Prostate-derived soluble factors block osteoblast differentiation in culture. J. Cell. Biochem., 61: 18-25.
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29:   Miletic, M., S. Mojsilovic, I. Okic-Dordevic, T. Kukolj and A. Jaukovic et al., 2014. Mesenchymal stem cells isolated from human periodontal ligament. Arch. Biol. Sci., 66: 261-271.
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30:   Mojsilovic, S. and J.F. Santibanez, 2015. Transforming growth factor-beta differently regulates urokinase type plasminogen activator and matrix metalloproteinase-9 expression in mouse macrophages; analysis of intracellular signal transduction. Cell Biol. Int., (In Press). 10.1002/cbin.10435.
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31:   Mojsilovic, S., A. Krstic, V. Ilic, I. Okic-Dordevic and J. Kocic et al., 2011. IL-17 and FGF signaling involved in mouse mesenchymal stem cell proliferation. Cell Tissue Res., 346: 305-316.
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32:   Nikolic, N., A. Krsti, D. Trivanovic, S. Mojsilovic and J. Kocic et al., 2011. Mesenchymal stem cell properties of dental pulp cells from deciduous teeth. Arch. Biol. Sci., 63: 933-942.
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33:   Okic-Djordjevic, I., D. Trivanovic, J. Krstic, A. Jaukovic and S. Mojsilovic et al., 2013. GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells. JBUON, 18: 504-510.
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34:   Perez-Gomez, E., G. del Castillo, J.F. Santibanez, J.M. Lepez-Novoa, C. Bernabeu and M. Quintanilla, 2010. The role of the TGF-β coreceptor endoglin in cancer. Sci. World J., 10: 2367-2384.
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35:   Quintanilla, M., G. del Castillo, J. Kocic and J.F. Santibanez, 2012. TGF-B and MMPs: A Complex Regulatory Loop Involved in Tumor Progression. In: Matrix Metalloproteinases: Biology, Functions and Clinical Implications. Oshiro, N. and E. Miyagi (Eds.). Nova Science Publishers, New York, USA., pp: 1-37.
36:   Quintanilla, M., P. Frontelo, J.F. Santibanez, D. Illescas, O. Berlanga and F. Scholl, 1998. Carcinogenesis experimental. El modelo de la carcinogenesis de piel de raton. Oncologia, 21: 35-40.
37:   Quintanilla, M., P. Frontelo, J.F. Santibanez, F. Scholl, M. Garcia Gallo and M. Iglesias, 1999. El modelo experimental de la carcinogenesis de piel de raton. Una vision integrada del Cancer. Rev. Cancer, 13: 41-47.
38:   Rodriguez, J.P., J.F. Santibanez and J. Martinez, 1998. Soluble factors secreted by PC-3 cells induce structural changes in proteoglycans produced by fetal rat osteoblasts. Tumour. Biol., 19: 19-29.
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39:   Rodriguez, J.P., S. Rios, M. Fernandez and J.F. Santibanez, 2004. Differential activation of ERK1,2 MAP kinase signaling pathway in mesenchymal stem cell from control and osteoporotic postmenopausal women. J. Cell Biochem., 92: 745-754.
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40:   Ronco, A.M., M. Tijmes, J.F. Santibanez and P. Moraga, 1998. Effect of desialylated human chorionic gonadotropin (hCG) on the bioactivity of rat Leydig cells. Cell. Biochem. Funct., 16: 21-28.
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41:   Santibanez, J.F. and C. Hurtado, 2005. Ha-Ras sensitizes transformed mouse skin cells to Anisomycin-induced apoptosis. FEBS Lett., 579: 6459-6464.
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42:   Santibanez, J.F. and J. Kocic, 2012. Transforming growth factor-β superfamily, implications in development and differentiation of stem cells. Biomol. Concepts, 3: 429-445.
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43:   Santibanez, J.F. and J. Krstic, 2014. Transforming Growth Factor-beta Regulation of Urokinase Type Plasminogen System: Mutual Interactions and Potential Combinatory Implications in Oncotherapies. In: Plasminogen Activator: Genetic Factors, Functions and Clinical Applications, Rutherford, J.M. (Ed.). Nova Science Publishers, USA., ISBN: 978-1-63117-354-7, pp: 139-208.
44:   Santibanez, J.F. and J. Martinez, 1993. Membrane-associated procollagenase of leukemic cells is activated by urokinase-type plasminogen activator. Leuk. Res., 17: 1057-1062.
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45:   Santibanez, J.F., 2006. JNK mediates TGF-β1-induced epithelial mesenchymal transdifferentiation of mouse transformed keratinocytes. FEBS Lett., 580: 5385-5391.
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46:   Santibanez, J.F., 2013. Transforming growth factor-beta and urokinase-type plasminogen activator: Dangerous partners in tumorigenesis-implications in skin cancer. ISRN Dermatol. 10.1155/2013/597927.
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47:   Santibanez, J.F., A. Letamendia, F. Perez-Barriocanal, C. Silvestri and M. Saura et al., 2007. Endoglin increases eNOS expression by modulating Smad2 protein levels and Smad2-dependent TGF-β signaling. J. Cell Physiol., 210: 456-468.
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48:   Santibanez, J.F., A. Navarro and J. Martinez, 1997. Genistein inhibits proliferation and In vitro invasive potential of human prostatic cancer cell lines. Anticancer Res., 17: 1199-1204.
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49:   Santibanez, J.F., D. Olivares, J. Guerrero and J. Martinez, 2003. Cyclic AMP inhibits TGFβ1-induced cell-scattering and invasiveness in murine-transformed keratinocytes. Int. J. Can., 107: 715-720.
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50:   Santibanez, J.F., E. Perez-Gomez, A. Fernandez-L, E.M. Garrido-Martin and A. Carnero et al., 2010. The TGF-β co-receptor endoglin modulates the expression and transforming potential of H-Ras. Carcinogenesis, 31: 2145-2154.
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51:   Santibanez, J.F., F.J. Blanco, E.M. Garrido-Martin, F. Sanz-Rodriguez, M.A. del Pozo and C. Bernabeu, 2008. Caveolin-1 interacts and cooperates with the transforming growth factor-β type I receptor ALK1 in endothelial caveolae. Cardiovasc. Res., 77: 791-799.
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52:   Santibanez, J.F., J. Guerrero, M. Quintanilla, A. Fabra and J. Martinez, 2002. Transforming growth factor-β1 modulates matrix metalloproteinase-9 production through the Ras/MAPK signaling pathway in transformed keratinocytes. Biochem. Biophys. Res. Commun., 296: 267-273.
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53:   Santibanez, J.F., J. Kocic, A. Fabra, A. Cano and M. Quintanilla, 2010. Rac1 modulates TGF-β1-mediated epithelial cell plasticity and MMP9 production in transformed keratinocytes. FEBS Lett., 584: 2305-2310.
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54:   Santibanez, J.F., M. Iglesias, P. Frontelo, J. Martinez and M. Quintanilla, 2000. Involvement of the Ras/MAPK signaling pathway in the modulation of urokinase production and cellular invasiveness by transforming growth factor-β1 in transformed keratinocytes. Biochem. Biophys. Res. Commun., 273: 521-527.
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55:   Santibanez, J.F., M. Quintanilla and C. Bernabeu, 2011. TGF-β/TGF-β receptor system and its role in physiological and pathological conditions. Clin. Sci., 121: 233-251.
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56:   Santibanez, J.F., M. Quintanilla and J. Martinez, 2000. Genistein and curcumin block TGF-β1-induced u-PA expression and migratory and invasive phenotype in mouse epidermal keratinocytes. Nutr. Cancer, 37: 49-54.
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57:   Santibanez, J.F., M. Quintanilla and J. Martinez, 2002. TGF-β1 and Smad4 overexpression induce a less invasive phenotype in highly invasive spindle carcinoma cells. FEBS Lett., 520: 171-176.
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58:   Santibanez, J.F., P. Frontelo, M. Iglesias, J. Martinez and M. Quintanilla, 1999. Urokinase expression and binding activity associated with the transforming growth factor β1-induced migratory and invasive phenotype of mouse epidermal keratinocytes. J. Cell Biochem., 74: 61-73.
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59:   Santibanez, J.F., R.B. Maccioni and J. Martinez, 1995. The secretion of urokinase-like plasminogen activator is inhibited by microtubule-interacting drugs. Cell. Biochem. Funct., 13: 217-225.
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60:   Santibanez, J.F., S. Silva and J. Martinez, 1996. Soluble factors produced by PC-3 prostate cells decrease collagen content and mineralisation rate in fetal rat osteoblasts in culture. Br. J. Cancer, 74: 418-422.
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61:   Smith, P.C., J.F. Santibanez, J.P. Morales and J. Martinez, 2004. Epidermal growth factor stimulates urokinase-type plasminogen activator expression in human gingival fibroblasts. Possible modulation by genistein and curcumin. J. Periodontal Res., 39: 380-387.
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62:   Tobar, N., M. Caceres, J.F. Santibanez, P.C. Smith and J. Martinez, 2008. RAC1 activity and intracellular ROS modulate the migratory potential of MCF-7 cells through a NADPH oxidase and NFκB-dependent mechanism. Cancer Lett., 267: 125-132.
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63:   Tobar, N., V. Villar and J.F. Santibanez, 2010. ROS-NFκΒ mediates TGF-β1-induced expression of urokinase-type plasminogen activator, matrix metalloproteinase-9 and cell invasion. Mol. Cell. Biochem., 340: 195-202.
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64:   Trivanovic, D., J. Kocic, S. Mojsilovic, A. Krstic and V. Ilic et al., 2013. Mesenchymal stem cells isolated from peripheral blood and umbilical cord Wharton's jelly. Srpski arhiv za celokupno lekarstvo, 141: 178-186.
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65:   Trivanovic, D., S. Mojsilovic, V. Ilic, J. Krstic and A. Jaukovic et al., 2013. Immunomodulatory capacity of human mesenchymal stem cells isolated from adipose tissue, dental pulp, peripheral blood and umbilical cord Wharton's jelly. Cent. Eur. J. Immunol., 38: 421-429.
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66:   Trivanovic, D., S. Nikolic, J. Krstic, A. Jaukovic and S. Mojsilovic et al., 2014. Characteristics of human adipose mesenchymal stem cells isolated from healthy and cancer affected people and their interactions with human breast cancer cell line MCF-7 in vitro. Cell Biol. Int., 38: 254-265.
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67:   Villar, V., J. Kocic and J.F. Santibanez, 2010. Spred2 inhibits TGF-β1-induced urokinase type plasminogen activator expression, cell motility and epithelial mesenchymal transition. Int. J. Cancer, 127: 77-85.
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68:   Villar, V., J. Kocic and J.F. Santibanez, 2013. SKIP regulates TGF-β 1-induced extracellular matrix degrading proteases expression in human PC-3 prostate cancer cells. Prostate Can. 10.1155/2013/398253.
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69:   Villar, V., J. Kocic, D. Bugarski, G. Jovcic and J.F. Santibanez, 2010. SKIP is required for TGF-β1-induced epithelial mesenchymal transition and migration in transformed keratinocytes. FEBS Lett., 584: 4586-4592.
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