Dr. Yasmin Anum Mohd Yusof
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Dr. Yasmin Anum Mohd Yusof

Professor
Universiti Kebangsaan Malaysia, Malaysia

Highest Degree
Ph.D. in Biochemistry from Flinders University, South Australia

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Area of Interest:

Biomedical Sciences
100%
Antioxidant Activities
62%
Anti-inflammatory
90%
Chemoprevention
75%
Liver Diseases
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Durani, L.W., S.C. Khor, J.K. Tan, K.H. Chua, Y.A.M. Yusof and S. Makpol, 2017. Piper betle L. modulates senescence-associated genes expression in replicative senescent human diploid fibroblasts. BioMed Res. Int. 10.1155/2017/6894026.
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  2. Arrozi, A.P., W.Z.W. Ngah, Y.A.M. Yusof, M.H.A. Damanhuri and S. Makpol, 2017. Antioxidant modulation in restoring mitochondrial function in neurodegeneration. Int. J. Neurosci., 127: 218-235.
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  3. Arrozi, A.P., S.N.S. Shukri, W.Z.W. Ngah, Y.A.M. Yusof, M.H.A. Damanhuri and S. Makpol, 2017. Evaluation of the expression of amyloid precursor protein and the ratio of secreted amyloid beta 42 to amyloid beta 40 in SH-SY5Y cells stably transfected with wild-type, single-mutant and double-mutant forms of the APP gene for the study of Alzheimer's disease pathology. Applied Biochem. Biotechnol., 183: 853-866.
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  4. Arifin, K.T., S. Sulaiman, S.M. Saad, H.A. Damanhuri, W.Z.W. Ngah and Y.A.M. Yusof, 2017. Elevation of tumour markers TGF-β, M 2-PK, OV-6 and AFP in Hepatocellular Carcinoma (HCC)-induced rats and their suppression by microalgae Chlorella vulgaris. BMC Cancer, Vol. 17. 10.1186/s12885-017-3883-3.
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  5. Yusof, Y.A.M., 2016. Gingerol and its Role in Chronic Diseases. In: Drug Discovery from Mother Nature, Gupta, S.C., S. Prasad and B.B. Aggarwal (Eds.). Springer International Publishing, Switzerland, ISBN: 978-3-319-41341-9, pp: 177-207.
  6. Yusof, A.M., N.A. Ghafar, T.A. Kamarudin, C.K. Hui and Y.A.M. Yusof, 2016. Gelam honey potentiates ex vivo corneal keratocytes proliferation with desirable phenotype expression. BMC Complement. Altern. Med., Vol. 16. 10.1186/s12906-016-1055-7.
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  7. Khor, S.C., M.R. Azraul, W.N.W. Zurinah, M.Y.Y Anum, A.K. Norwahidah and M.Suzana, 2016. The tocotrienol-rich fraction is superior to tocopherol in promoting myogenic differentiation in the prevention of replicative senescence of myoblasts. PLoS ONE, Vol. 11. 10.1371/journal.pone.0149265.
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  8. Aliahmat, N.S., N.F.A. Sani, W.N.W. Hasan, S. Makpol, W.Z.W. Ngah and Y.A.M. Yusof, 2016. Piper betle induced cytoprotective genes and proteins via the Nrf2/ARE pathway in aging mice. J. Nutrigenet. Nutrigenom., 9: 243-253.
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  9. Wee, L.H., N.A. Morad, G.J. Aan, S. Makpol, W.Z.W. Ngah and Y.A.M. Yusof, 2015. Mechanism of chemoprevention against colon cancer cells using combined Gelam honey and Ginger extract via mTOR and Wnt/β-catenin pathways. Asian Pac. J. Cancer Prev., 16: 6549-6556.
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  10. Tahir, A.A., N.F.A. Sani, N.A. Murad, S. Makpol, W.Z.W. Ngah and Y.A.M. Yusof, 2015. Combined ginger extract and Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells. Nutr. J., Vol. 14. 10.1186/s12937-015-0015-2.
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  11. Ker-Woon, C., N.A. Ghafar, C.K. Hui, Y.A.M. Yusof and W.Z.W. Ngah, 2015. The effects of acacia honey on in vitro corneal abrasion wound healing model. BMC Cell Biol., Vol. 16. 10.1186/s12860-015-0053-9.
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  12. Jaapar, S.Z.S., N.A. Morad, Y. Iwai, M.S.M. Sarip, M.A.C. Yunus and Y.A.M. Yusuff, 2015. Estimation of ginger bioactive compound solubilities in hot compressed water and enhancement with entrainer. Fluid Phase Equilibria, 393: 40-47.
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  13. Ibrahim, K., R. Ramli, A.H. Rashid and Y.A.M. Yusof, 2015. Antimicrobial property of water and ethanol extract Chlorella vulgaris: A value-added advantage for a new wound dressing material. Int. Med. J., 22: 399-401.
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  14. Wan Hasan, W.N., M.K. Kwak, S. Makpol, W.Z. Wan Ngah and Y.A.M. Yusof, 2014. Piper betle induces phase I and II genes through Nrf2/ARE signaling pathway in mouse embryonic fibroblasts derived from wild type and Nrf2 knockout cells. BMC Complement. Altern. Med., Vol. 14. 10.1186/1472-6882-14-72.
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  15. Sarip, M.S.M., N.A. Morad, N.A.M. Ali, Y.A.M. Yusof and M.A.C. Yunus, 2014. The kinetics of extraction of the medicinal ginger bioactive compounds using hot compressed water. Sep. Purif. Technol., 124: 141-147.
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  16. Ng, P.L., N.F. Rajab, S.M. Then, Y.A.M. Yusof, W.Z.W. Ngah, K.Y. Pin and M.L. Looi, 2014. Piper betle leaf extract enhances the cytotoxicity effect of 5-fluorouracil in inhibiting the growth of HT29 and HCT116 colon cancer cells. J. Zhejiang Univ. Sci. B, 15: 692-700.
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  17. Khor, S.C., N. Abdul Karim, W.Z.W. Ngah, Y.A.M. Yusof and S. Makpol, 2014. Vitamin E in sarcopenia: Current evidences on its role in prevention and treatment. Oxid. Med. Cell. Longevity. 10.1155/2014/914853.
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  18. Khee, S.G.S., Y.A.M. Yusof and S. Makpol, 2014. Expression of senescence-associated microRNAs and target genes in cellular aging and modulation by tocotrienol-rich fraction. Oxid. Med. Cell. Longevity. 10.1155/2014/725929.
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  19. Ker-Woon, C., N.A. Ghafar, C.K. Hui, Y.A.M. Yusof and N.S. Luan, 2014. Proliferative capacity of in vitro corneal epithelium: Role of Acacia honey in the initial step of wound healing. J. Med. Bioeng., 3: 107-112.
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  20. Ker-Woon, C., N.A. Ghafar, C.K. Hui and Y.A.M. Yusof, 2014. Effect of acacia honey on cultured rabbit corneal keratocytes. BMC Cell Biol., Vol. 15. 10.1186/1471-2121-15-19.
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  21. Hussein, S.Z., K.M. Yusoff, S. Makpol and Y.A.M. Yusof, 2014. Does gamma irradiation affect physicochemical properties of honey? Clin. Terapeut., 165: e125-e133.
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  22. Hamzah, N., S.A. Aziz, A.R. Fauzi, Y.A. Yusof, M. Razali, N. Ibrahim and B. Baharin, 2014. Effects of gelam honey (Melaleuca cajuputi) on alveolar bone loss in experimental periodontitis. J. Dental Surg. 10.1155/2014/907970.
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  23. Hakim, L., E. Alias, S. Makpol, W.Z.W. Ngah, N.A. Morad and Y.A.M. Yusof, 2014. Gelam honey and ginger potentiate the anti cancer effect of 5-FU against HCT 116 colorectal cancer cells. Asian Pac. J. Cancer Prev., 15: 4651-4657.
    CrossRef  |  PubMed  |  Direct Link  |  
  24. Aziz, S.A., N. Hamzah, A.R. Fauzi, Y.A.M. Yusof and N. Ibrahim et al., 2014. The effect of gelam (Melaleuca cajuputi) honey on inflammatory mediators in periodontitis-induced Sprague-Dawley rats. Int. J. Applied Res. Nat. Prod., 7: 7-16.
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  25. Abdul Sani, N.F., L.K. Belani, C.P. Sin, S.N.A. Abdul Rahman and S. Das et al., 2014. Effect of the combination of gelam honey and ginger on oxidative stress and metabolic profile in streptozotocin-induced diabetic Sprague-Dawley rats. BioMed Res. Int. 10.1155/2014/160695.
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  26. Saberbaghi, T., F. Abbasian, Y.A. Mohd Yusof and S. Makpol, 2013. Modulation of cell cycle profile by Chlorella vulgaris prevents replicative senescence of human diploid fibroblasts. Evidence-Based Complement. Altern. Med. 10.1155/2013/780504.
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  27. Saba, Z.H., M. Suzana and M.Y.Y. Anum, 2013. Honey: Food or medicine. Med. Health, 8: 3-18.
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  28. Rashid, Z., I. Isahak, C. Jeann, M. Suki and N. Mohamad et al., 2013. Oro-pharyngeal carriage and antimicrobial susceptibility of Streptococcus pneumoniae from healthy children. Internet J. Microbiol., Vol. 11, No. 1. .
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  29. Mukti, N.A., M.A. Rahman, S.A. Karsani, W. Ngah, W. Zurinah, M. Yusof and Y. Anum, 2013. A purified novel protein from the culture media of Chlorella vulgaris inhibits growth and induces cell death in hepatoma HepG2 cells. Int. Med. J., 20: 140-145.
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  30. Makpol, S., F.A. Jam, S.C. Khor, Z. Ismail, Y.A.M. Yusof and W.Z.W. Ngah, 2013. Comparative effects of biodynes, tocotrienol-rich fraction and tocopherol in enhancing collagen synthesis and inhibiting collagen degradation in stress-induced premature senescence model of human diploid fibroblasts. Oxid. Med. Cell. Longevity. 10.1155/2013/298574.
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  31. Makpol, S., A. Zainuddin, K.H. Chua, Y.A.M. Yusof and W.Z.W. Ngah, 2013. Gamma-tocotrienol modulated gene expression in senescent human diploid fibroblasts as revealed by microarray analysis. Oxid. Med. Cell. Longevity. 10.1155/2013/454328.
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  32. Hussein, S.Z., K.M. Yusoff, S. Makpol and Y.A.M. Yusof, 2013. Gelam honey attenuates carrageenan-induced rat paw inflammation via NF-κB pathway. PLoS ONE, Vol. 8. 10.1371/journal.pone.0072365.
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  33. Esa, F., W.Z.W. Ngah, A.R.A. Jamal and Y.A.M. Yusof, 2013. Inhibition of β-catenin and KRAS expressions by piper betle in azoxymethane-induced colon cancer of male fischer 344 rats. Anal. Quant. Cytopathol. Histopathol., 35: 324-331.
    PubMed  |  
  34. Ahmad, T.A.F.T., Z. Jubri, N.F. Rajab, K.A. Rahim, Y.A.M. Yusof and S. Makpol, 2013. Gelam honey protects against gamma-irradiation damage to antioxidant enzymes in human diploid fibroblasts. Molecules, 18: 2200-2211.
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  35. Wen, C.T.P., S.Z. Hussein, S. Abdullah, N.A. Karim, S. Makpol and Y.A.M. Yusof, 2012. Gelam and nenas honeys inhibit proliferation of HT 29 colon cancer cells by inducing DNA damage and apoptosis while suppressing inflammation. Asian Pac. J. Cancer Prev., 13: 1605-1610.
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  36. Makpol, S., T.A.F.T. Ahmad, Z. Jubri, N. Rejab, N. Yusof and Y.A.M. Yusof, 2012. Gelam honey acting as a radioprotectant agent in gamma-irradiated human diploid fibroblasts. J. Med. Plants Res., 6: 129-138.
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  37. Makpol, S., A. Zainuddin, K.H. Chua, Y.A.M. Yusof and W.Z.W. Ngah, 2012. Gamma-tocotrienol modulation of senescence-associated gene expression prevents cellular aging in human diploid fibroblasts. Clinics, 67: 135-143.
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  38. Hussein, S.Z., K.M. Yusoff, S. Makpol and Y.A.M. Yusof, 2012. Gelam honey inhibits the production of proinflammatory, mediators NO, PGE2, TNF-α and IL-6 in carrageenan-induced acute paw edema in rats. Evidence-Based Complement. Altern. Med. 10.1155/2012/109636.
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  39. Aliahmat, N.S., M.R.M. Noor, W.J.W. Yusof, S. Makpol, W.Z.W. Ngah and Y.A.M. Yusof, 2012. Antioxidant enzyme activity and malondialdehyde levels can be modulated by Piper betle, tocotrienol rich fraction and Chlorella vulgaris in aging C57BL/6 mice. Clinics, 67: 1447-1454.
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  40. Aini, A.H.N., A.K.N. Najwa, I.A.A. Ibrahim, S.B. Prasamit and J.A. Goon et al., 2012. Effects of Tai Chi exercise on physiological and biochemical changes among middle-aged adults. Clin. Exp. Med. Lett., 53: 101-105.
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  41. Yusof, Y.A.M., J.M.H. Basari, N.A. Mukti, R. Sabuddin and A.R. Muda et al., 2011. Fatty acids composition of microalgae Chlorella vulgaris can be modulated by varying carbon dioxide concentration in outdoor culture. Afr. J. Biotechnol., 10: 13536-13542.
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  42. Makpol, S., L.W. Durani, K.H. Chua, M. Yusof, Y. Anum, W. Ngah and W. Zurinah, 2011. Tocotrienol-rich fraction prevents cell cycle arrest and elongates telomere length in senescent human diploid fibroblasts. J. Biomed. Biotechnol. 10.1155/2011/506171.
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  43. Makpol, S., F.A. Jam, Y.A.M. Yusof and W.Z.W. Ngah, 2011. Modulation of collagen synthesis and its gene expression in human skin fibroblasts by tocotrienol-rich fraction. Arch. Med. Sci., 7: 889-895.
    CrossRef  |  Direct Link  |  
  44. Hussein, S.Z., K.M. Yusoff, S. Makpol and Y.A.M. Yusof, 2011. Antioxidant capacities and total phenolic contents increase with gamma irradiation in two types of Malaysian honey. Molecules, 16: 6378-6395.
    CrossRef  |  Direct Link  |  
  45. Hamid, N.A.A., M.A. Hasrul, R.J. Ruzanna, I.A. Ibrahim and P.S. Baruah et al., 2011. Effect of vitamin E (Tri E®) on antioxidant enzymes and DNA damage in rats following eight weeks exercise. Nutr. J., Vol. 10. 10.1186/1475-2891-10-37.
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  46. Zailan, N., A.H.A. Rashid, S. Das, N.A.A. Mokti and J.H. Basri et al., 2010. Comparison of Chlorella vulgaris dressing and sodium alginate dressing: An experimental study in rats. La Clinica Terapeutica, 161: 515-521.
    PubMed  |  Direct Link  |  
  47. Yusof, Y.A.M., S.M. Saad, S. Makpol, N.A. Shamaan and W.Z.W. Ngah, 2010. Hot water extract of Chlorella vulgaris induced DNA damage and apoptosis. Clinics, 65: 1371-1377.
    CrossRef  |  Direct Link  |  
  48. Makpol, S., A. Zainuddin, N.A. Rahim, Y.A.M. Yusof and W.Z.W. Ngah, 2010. Alpha-tocopherol modulates hydrogen peroxide-induced DNA damage and telomere shortening of human skin fibroblasts derived from differently aged individuals. Planta Medica, 76: 869-875.
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  49. Anum, M.Y.Y., I. Merican, L.B. Chee, W. Abdullah, M.R. Abu Hassan, N.A. Abdullah and N. Othman, 2010. Serum Transforming Growth Factor beta (TGF-b-1) is a better tumor marker for hepatocellular carcinoma than serum alpha fetoprotein (AFP). Malaysian J. Clin. Biochem., 5: 13-19.
  50. Aizzat, O., S.W. Yap, H. Sopiah, M.M. Madiha and M. Hazreen et al., 2010. Modulation of oxidative stress by Chlorella vulgaris in streptozotocin (STZ) induced diabetic Sprague-Dawley rats. Adv. Med. Sci., 55: 281-288.
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  51. Abdullah, S., S.A.Z. Abidin, N.A. Murad, S. Makpol, W.Z.W. Ngah and Y.A.M. Yusof, 2010. Ginger extract (Zingiber officinale) triggers apoptosis and G0/G1 cells arrest in HCT 116 and HT 29 colon cancer cell lines. Afr. J. Biochem. Res., 4: 134-142.
    Direct Link  |  
  52. Yusof, Y., N. Ahmad, S. Das, S. Sulaiman and N. Murad, 2009. Chemopreventive efficacy of ginger (Zingiber officinale) in ethionine induced rat hepatocarcinogenesis. Afr. J. Tradit. Complement. Altern. Med., 6: 87-93.
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  53. Mukti, N.A., S. Sulaiman, S.M. Saad, J.M.H. Basari, M.A. Rahman, W.Z.W. Ngah and Y.A.M. Yusof, 2009. Chlorella vulgaris exhibited antioxidant and antitumour effects against liver cancer in in vivo and in vitro studies. Sains Malaysiana, 38: 773-784.
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  54. Makpol, S., N.N.M. Arifin, Z. Ismail, C.K. Hui, Y.A.M. Yusof and W.Z.W. Ngah, 2009. Modulation of melanin synthesis and its gene expression in skin melanocytes by palm tocotrienol rich fraction. Afr. J. Biochem. Res., 3: 385-392.
    Direct Link  |  
  55. Makpol, S., N. Yaacob, A. Zainuddin, Y. Yusof and W. Ngah, 2009. Chlorella vulgaris modulates hydrogen peroxide-induced DNA damage and telomere shortening of human fibroblasts derived from different aged individuals. Afr. J. Tradit. Complement. Altern. Med., 6: 560-572.
    CrossRef  |  Direct Link  |  
  56. Makpol, S., M.A.N. Nadia, I. Zahariah, K.H. Chua, M.Y.Y. Anum and W.N.W. Zurinah, 2009. Melanogenesis inhibition by palm Tocotrienol Rich Fraction in cellular ageing. Med. Health, 4: 25-34.
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  57. Looi, M.L., S.A. Karsani, M.A. Rahman, A.Z.H.M. Dali, S.A.M. Ali, W.Z.W. Ngah and Y.A.M. Yusof, 2009. Plasma proteome analysis of cervical intraepithelial neoplasia and cervical squamous cell carcinoma. J. Biosci., 34: 917-925.
    Direct Link  |  
  58. Goon, J.A., A.N. Aini, M. Musalmah, M.Y. Anum, W.W. Nazaimoon and W.W. Ngah, 2009. Effect of Tai Chi exercise on DNA damage, antioxidant enzymes and oxidative stress in middle-age adults. J. Phys. Activity Health, 6: 43-54.
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  59. Azamai, E.S.M., S. Sulaiman, S.H.M. Habib, M.L. Looi and S. Das et al., 2009. Chlorella vulgaris triggers apoptosis in hepatocarcinogenesis-induced rats. J. Zhejiang Univ. Sci. B, 10: 14-21.
    CrossRef  |  Direct Link  |  
  60. Anum, M.Y.Y., M.L. Looi, A.H.N. Aini, I. Merican and A. Wahidah et al., 2009. Combined assessment of TGF-beta-1 and alpha-fetoprotein values improves specificity in the diagnosis of hepatocellular carcinoma and other chronic liver diseases in Malaysia. Med. J. Malaysia, 64: 223-227.
    PubMed  |  Direct Link  |  
  61. Yasmin Anum, M.Y., Z.A. Shahriza, M.L. Looi, M.H. Shafina Hanim and H. Harlianshah et al., 2008. Ginger extract (Zingiber officinale Roscoe) triggers apoptosis in hepatocarcinogenesis induced rats. Med. Health, 3: 263-274.
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  62. Looi, M.L., A.Z.H.M. Dali, S.A.M. Ali, W.Z.W. Ngah and Y.A.M. Yusof, 2008. Oxidative damage and antioxidant status in patients with cervical intraepithelial neoplasia and carcinoma of the cervix. Eur. J. Cancer Prev., 17: 555-560.
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  63. Looi, M.L., A.Z.H.M. Dali, S.A.M. Ali, W.Z.W. Ngah and Y.A.M. Yusof, 2008. Expression of p53, bcl-2 and Ki-67 in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix. Anal. Quant. Cytol. Histol., 30: 63-70.
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  64. Habib, S.H.M., S. Makpol, N.A.A. Hamid, S. Das, W.Z.W. Ngah and Y.A.M. Yusof, 2008. Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory effects on ethionine-induced hepatoma rats. Clinics, 63: 807-813.
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  65. Goon, J.A., A.H.N. Aini, M. Musalmah, M.Y.Y. Anum and W.Z.W. Ngah, 2008. Long term Tai Chi exercise reduced DNA damage and increased lymphocyte apoptosis and proliferation in older adults. Med. J. Malaysia, 63: 319-324.
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  66. Chin, S.F., N.A.A. Hamid, A.A. Latiff, Z. Zakaria and M. Mazlan et al., 2008. Reduction of DNA damage in older healthy adults by Tri E® Tocotrienol supplementation. Nutrition, 24: 1-10.
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  67. Harliansyah, N.A. Murad, W.Z. Wan Ngah and Y.A.M. Yusof, 2007. Antiproliferative, antioxidant and apoptosis effects of Zingber officinal and 6-Gingerol on HepG2 cells. Asian J. Biochem., 2: 421-426.
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