Dr. Somchai  Pinlaor

Dr. Somchai Pinlaor

Associate Professor
Khon Kaen University, Thailand


Highest Degree
Ph.D. in Medical Biochemistry from Khon Kaen University, Thailand

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Area of Interest:

Biomedical Sciences
100%
Parasitology
62%
Biochemistry
90%
Cholangiocarcinoma
75%
Molecular Carcinogenesis
55%

Education

2004

Ph.D.

Khon Kaen University, Thailand

Medical Biochemistry

Selected Publications

  1. Umawadee, L., P. Porntip, B. Patcharee, P. Chawalit and P. Aroonsri et al., 2013. Melatonin inhibits cholangiocarcinoma and reduces liver injury in Opisthorchis viverrini‐infected and N‐nitrosodimethylamine‐treated hamsters. J. Pineal Res., 55: 257-266.
    CrossRef  |  

  2. Thanan, R., C. Pairojkul, S. Pinlaor, N. Khuntikeo and C. Wongkham et al., 2013. Inflammation-related DNA damage and expression of CD133 and Oct3/4 in cholangiocarcinoma patients with poor prognosis. Free Radic. Biol. Med., 65: 1464-1472.
    CrossRef  |  

  3. Sriraj, P., R. Aukkanimart, T. Boonmars, N. Wonkchalee and A. Juasook et al., 2013. Alcohol and alkalosis enhance excystation of Opisthorchis viverrini metacercariae. Parasitol. Res., 112: 2397-2402.
    CrossRef  |  

  4. Laothong, U., P. Pinlaor, P. Boonsiri, Y. Hiraku and J. Khoontawad et al., 2013. α-Tocopherol and lipid profiles in plasma and the expression of α-tocopherol-related molecules in the liver of Opisthorchis viverrini-infected hamsters. Parasitol. Int., 62: 127-133.
    CrossRef  |  

  5. Khoontawad, J., N. Hongsrichan, Y. Chamgramol, P. Pinlaor and C. Wongkham et al., 2013. Increase of exostosin 1 in plasma as a potential biomarker for opisthorchiasis-associated cholangiocarcinoma. Tumor Biol., 10.1007/s13277-013-1137-9.
    CrossRef  |  

  6. Jantermtor, S., P. Pinlaor, K. Sawadpanich, S. Pinlaor and A. Sangka et al., 2013. Subtype identification of Blastocystis spp. isolated from patients in a major hospital in northeastern Thailand. Parasitol. Res., 112: 1781-1786.
    CrossRef  |  PubMed  |  

  7. Hongsrichan, N., R. Rucksaken, Y. Chamgramol, P. Pinlaor and A. Techasen et al., 2013. Annexin A1: A new immunohistological marker of cholangiocarcinoma. World J. Gastroenterol., 19: 2456-2665.
    Direct Link  |  

  8. Hanpanich, P., S. Pinlaor, L. Charoensuk, P. Yongvanit, C. Thomas, S. Kothan and E. Mairiang, 2013. MRI and 1 H MRS evaluation for the serial bile duct changes in hamsters after infection with Opisthorchis viverrini. Magnet. Resonance Imaging, 31: 1418-1425.
    CrossRef  |  

  9. Yongvanit, P., S. Pinlaor and H. Bartsch, 2012. Oxidative and nitrative DNA damage: Key events in opisthorchiasis-induced carcinogenesis. Parasitol. Int., 61: 130-135.
    CrossRef  |  

  10. Yongvanit, P., R. Thanan, S. Pinlaor, P. Sithithaworn and W. Loilome et al., 2012. Increased expression of TLR-2, COX-2 and SOD-2 genes in the peripheral blood leukocytes of opisthorchiasis patients induced by Opisthorchis viverrini antigen. Parasitol. Res., 110: 1969-1977.
    CrossRef  |  

  11. Wu, Z., T. Boonmars, I. Nagano, S. Boonjaraspinyo and S. Pinlaor et al., 2012. Alteration of galectin-1 during tumorigenesis of Opisthorchis viverrini infection-induced cholangiocarcinoma and its correlation with clinicopathology. Tumor Biol., 33: 1169-1178.
    CrossRef  |  

  12. Thanan, R., S. Oikawa, P. Yongvanit, Y. Hiraku and N. Ma et al., 2012. Inflammation-induced protein carbonylation contributes to poor prognosis for cholangiocarcinoma. Free Radic. Biol. Med., 52: 1465-1472.
    CrossRef  |  

  13. Thanan, R., N. Ma, K. Iijima, Y. Abe and T. Koike et al., 2012. Proton pump inhibitors suppress iNOS-dependent DNA damage in Barrett's esophagus by increasing Mn-SOD expression. Biochem. Biophys. Res. Commun., 421: 280-285.
    CrossRef  |  

  14. Sawangsoda, P., J. Sithithaworn, S. Tesana, S. Pinlaor and T. Boonmars et al., 2012. Diagnostic values of parasite-specific antibody detections in saliva and urine in comparison with serum in opisthorchiasis. Parasitol. Int., 61: 196-202.
    CrossRef  |  

  15. Rucksaken, R., J. Khoontawad, S. Roytrakul, P. Pinlaor and Y. Hiraku et al., 2012. Proteomic analysis to identify plasma orosomucoid 2 and kinesin 18A as potential biomarkers of cholangiocarcinoma. Cancer Biomarkers, 12: 81-95.
    CrossRef  |  

  16. Prasongwatana, J., P. Laummaunwai, T. Boonmars and S. Pinlaor, 2012. Viable metacercariae of Opisthorchis viverrini in northeastern Thai cyprinid fish dishes-as part of a rational program for control of O. viverrini-associated cholangiocarcinoma. Parasitol. Res., 112: 1323-1327.
    CrossRef  |  

  17. Prakobwong, S., P. Pinlaor, L. Charoensuk, J. Khoontawad, P. Yongvanit, Y. Hiraku and S. Pinlaor, 2012. The liver fluke Opisthorchis viverrini expresses nitric oxide synthase but not gelatinases. Parasitol. Int., 61: 112-117.
    CrossRef  |  

  18. Prakobwong, S., L. Charoensuk, Y. Hiraku, P. Pinlaor and C. Pairojkul et al., 2012. Plasma hydroxyproline, MMP‐7 and collagen I as novel predictive risk markers of hepatobiliary disease‐associated cholangiocarcinoma. Int. J. Cancer, 131: E416-E424.
    CrossRef  |  

  19. Pinlaor, P., P. Pongsamart, N. Hongsrichan, A. Sangka and T. Srilunchang et al., 2012. Specific serum IgG, but not IgA, antibody against purified Opisthorchis viverrini antigen associated with hepatobiliary disease and cholangiocarcinoma. Parasitol. Int., 61: 212-216.
    CrossRef  |  

  20. Khoontawad, J., U. Laothong, S. Roytrakul, P. Pinlaor and J. Mulvenna et al., 2012. Proteomic identification of plasma protein tyrosine phosphatase alpha and fibronectin associated with liver fluke, Opisthorchis viverrini, infection. PloS One, Vol. 7. 10.1371/journal.pone.0045460.
    CrossRef  |  

  21. Jusakul, A., W. Loilome, N. Namwat, W.G. Haigh and R. Kuver et al., 2012. Liver fluke-induced hepatic oxysterols stimulate DNA damage and apoptosis in cultured human cholangiocytes. Mutat. Res. /Fundamental Mol. Mech. Mutag., 731: 48-57.
    CrossRef  |  

  22. Boonjaraspinyo, S., T. Boonmars, Z. Wu, W. Loilome and P. Sithithaworn et al., 2012. Platelet-derived growth factor may be a potential diagnostic and prognostic marker for cholangiocarcinoma. Tumor Biol., 33: 1785-1802.
    CrossRef  |  

  23. Boonjaraspinyo, S., T. Boonmars, S. Kaewkes, P. Laummaunwai and S. Pinlaor et al., 2012. Down-regulated expression of hsp70 in correlation with clinicopathology of cholangiocarcinoma. Pathol. Oncol. Res., 18: 227-237.
    CrossRef  |  

  24. Wu, Z., T. Boonmars, S. Boonjaraspinyo, I. Nagano and S. Pinlaor et al., 2011. Candidate genes involving in tumorigenesis of cholangiocarcinoma induced by Opisthorchis viverrini infection. Parasitol. Res., 109: 657-673.
    CrossRef  |  

  25. Prakobwong, S., J. Khoontawad, P. Yongvanit, C. Pairojkul and Y. Hiraku et al., 2011. Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation‐mediated molecular events related to multistep carcinogenesis. Int. J. Cancer, 129: 88-100.
    CrossRef  |  

  26. Charoensuk, L., P. Pinlaor, S. Prakobwong, Y. Hiraku and U. Laothong et al., 2011. Curcumin induces a nuclear factor-erythroid 2-related factor 2-driven response against oxidative and nitrative stress after praziquantel treatment in liver fluke-infected hamsters. Int. J. Parasitol., 41: 615-626.
    CrossRef  |  

  27. Boonmars, T., Z. Wu, S. Boonjaruspinyo, A. Puapairoj and B. Kaewsamut et al., 2011. Involvement of c-Ski oncoprotein in carcinogenesis of cholangiocacinoma induced by Opisthorchis viverrini and N-nitrosodimethylamine. Pathol. Oncol. Res., 17: 219-227.
    CrossRef  |  

  28. Subimerb, C., S. Pinlaor, V. Lulitanond, N. Khuntikeo, S. Okada, M.S. McGrath and S. Wongkham, 2010. Circulating CD14+ CD16+ monocyte levels predict tissue invasive character of cholangiocarcinoma. Clin. Exp. Immunol., 161: 471-479.
    CrossRef  |  

  29. Subimerb, C., S. Pinlaor, N. Khuntikeo, C. Leelayuwat, A. Morris, M.S. McGrath and S. Wongkham, 2010. Tissue invasive macrophage density is correlated with prognosis in cholangiocarcinoma. Mol. Med. Rep., 3: 597-605.
    CrossRef  |  

  30. Prakobwong, S., P. Yongvanit, Y. Hiraku, C. Pairojkul, P. Sithithaworn, P. Pinlaor and S. Pinlaor, 2010. Involvement of MMP‐9 in peribiliary fibrosis and cholangiocarcinogenesis via Rac1‐dependent DNA damage in a hamster model. Int. J. Cancer, 127: 2576-2587.
    CrossRef  |  

  31. Pinlaor, S., S. Prakobwong, Y. Hiraku, P. Pinlaor, U. Laothong and P. Yongvanit, 2010. Reduction of periductal fibrosis in liver fluke-infected hamsters after long-term curcumin treatment. Eur. J. Pharmacol., 638: 134-141.
    CrossRef  |  

  32. Laothong, U., P. Pinlaor, Y. Hiraku, P. Boonsiri, S. Prakobwong, J. Khoontawad and S. Pinlaor, 2010. Protective effect of melatonin against Opisthorchis viverrini‐induced oxdative and nitrosative DNA damage and liver injury in hamsters. J. Pineal Res., 49: 271-282.
    CrossRef  |  

  33. Khoontawad, J., C. Wongkham, Y. Hiraku, P. Yongvanit and S. Prakobwong et al., 2010. Proteomic identification of peroxiredoxin 6 for host defence against Opisthorchis viverrini infection. Parasite Immunol., 32: 314-323.
    CrossRef  |  

  34. Dechakhamphu, S., S. Pinlaor, P. Sitthithaworn, J. Nair, H. Bartsch and P. Yongvanit, 2010. Lipid peroxidation and etheno DNA adducts in white blood cells of liver fluke-infected patients: Protection by plasma α-tocopherol and praziquantel. Cancer Epidemiol. Biomarkers Prev., 19: 310-318.
    CrossRef  |  

  35. Dechakhamphu, S., S. Pinlaor, P. Sitthithaworn, H. Bartsch and P. Yongvanit, 2010. Accumulation of miscoding etheno-DNA adducts and highly expressed DNA repair during liver fluke-induced cholangiocarcinogenesis in hamsters. Mutat. Res., 691: 9-16.
    CrossRef  |  

  36. Prakobwong, S., S. Pinlaor, P. Yongvanit, P. Sithithaworn, C. Pairojkul and Y. Hiraku, 2009. Time profiles of the expression of metalloproteinases, tissue inhibitors of metalloproteases, cytokines and collagens in hamsters infected with Opisthorchis viverrini with special reference to peribiliary fibrosis and liver injury. Int. J. Parasitol., 39: 825-835.
    CrossRef  |  

  37. Pinlaor, S., S. Prakobwong, T. Boonmars, C. Wongkham, P. Pinlaor and Y. Hiraku, 2009. Effect of praziquantel treatment on the expression of matrix metalloproteinases in relation to tissue resorption during fibrosis in hamsters with acute and chronic Opisthorchis viverrini infection. Acta Tropica, 111: 181-191.
    CrossRef  |  

  38. Pinlaor, S., P. Yongvanit, S. Prakobwong, B. Kaewsamut, J. Khoontawad, P. Pinlaor and Y. Hiraku, 2009. Curcumin reduces oxidative and nitrative DNA damage through balancing of oxidant-antioxidant status in hamsters infected with Opisthorchis viverrini. Mol. Nutr. Food Res., 53: 1316-1328.
    CrossRef  |  

  39. Boonmars, T., Z. Wu, S. Boonjaruspinyo, S. Pinlaor and I. Nagano et al., 2009. Alterations of gene expression of RB pathway in Opisthorchis viverrini infection-induced cholangiocarcinoma. Parasitol. Res., 105: 1273-1281.
    CrossRef  |  

  40. Boonjaraspinyo, S., T. Boonmars, C. Aromdee, T. Srisawangwong and B. Kaewsamut et al., 2009. Turmeric reduces inflammatory cells in hamster opisthorchiasis. Parasitol. Res., 105: 1459-1463.
    CrossRef  |  

  41. Thanan, R., M. Murata, S. Pinlaor, P. Sithithaworn and N. Khuntikeo et al., 2008. Urinary 8-oxo-7, 8-dihydro-2'-deoxyguanosine in patients with parasite infection and effect of antiparasitic drug in relation to cholangiocarcinogenesis. Cancer Epidemiol. Biomarkers Prev., 17: 518-524.
    CrossRef  |  

  42. Pinlaor, S., S. Prakobwong, Y. Hiraku, B. Kaewsamut and S. Dechakhamphu et al., 2008. Oxidative and nitrative stress in Opisthorchis viverrini-infected hamsters: An indirect effect after praziquantel treatment. Am. J. Trop. Med. Hyg., 78: 564-573.
    Direct Link  |  

  43. Dechakhamphu, S., P. Yongvanit, J. Nair, S. Pinlaor, P. Sitthithaworn and H. Bartsch, 2008. High excretion of etheno adducts in liver fluke-infected patients: Protection by praziquantel against DNA damage. Cancer Epidemiol. Biomarkers Prev., 17: 1658-1664.
    CrossRef  |  Direct Link  |  

  44. Boonmars, T., P. Srirach, B. Kaewsamut, T. Srisawangwong and S. Pinlaor et al., 2008. Apoptosis-related gene expression in hamster opisthorchiasis post praziquantel treatment. Parasitol. Res., 102: 447-455.
    CrossRef  |  

  45. Boonmars, T., T. Srisawangwong, P. Srirach, B. Kaewsamut, S. Pinlaor and P. Sithithaworn, 2007. Apoptosis-related gene expressions in hamsters re-infected with Opisthorchis viverrini and re-treated with praziquantel. Parasitol. Res., 102: 57-62.
    CrossRef  |  

  46. Pinlaor, S., Y. Hiraku, P. Yongvanit, S. Tada-Oikawa and N. Ma et al., 2006. iNOS-dependent DNA damage via NF-kappaB expression in hamsters infected with Opisthorchis viverrini and its suppression by the antihelminthic drug praziquantel. Int. J. Cancer, 119: 1067-1072.
    CrossRef  |  PubMed  |  

  47. Kawanishi, S., Y. Hiraku, S. Pinlaor and N. Ma, 2006. Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis. Biol. Chem., 387: 365-372.
    CrossRef  |  

  48. Pinlaor, S., S. Tada-Oikawa, Y. Hiraku, P. Pinlaor, N. Ma, P. Sithithaworn and S. Kawanishi, 2005. Opisthorchis viverrini antigen induces the expression of Toll-like receptor 2 in macrophage RAW cell line. Int. J. Parasitol., 35: 591-596.
    CrossRef  |  

  49. Pinlaor, S., P. Mootsikapun, P. Pinlaor, V. Pipitgool and R. Tuangnadee, 2005. Detection of opportunistic and non-opportunistic intestinal parasites and liver flukes in HIV-positive and HIV-negative subjects. Southeast Asian J. Trop. Med. Public Health, 36: 841-845.

  50. Pinlaor, S., B. Sripa, N. Ma, Y. Hiraku and P. Yongvanit et al., 2005. Nitrative and oxidative DNA damage in intrahepatic cholangiocarcinoma patients in relation to tumor invasion. World J. Gastroenterol., 11: 4644-4649.

  51. Chaiyarit, P., N. Ma, Y. Hiraku, S. Pinlaor and P. Yongvanit et al., 2005. Nitrative and oxidative DNA damage in oral lichen planus in relation to human oral carcinogenesis. Cancer Sci., 96: 553-559.
    CrossRef  |  

  52. Pinlaor, S., Y. Hiraku, N. Ma, P. Yongvanit and R. Semba et al., 2004. Mechanism of NO-mediated oxidative and nitrative DNA damage in hamsters infected with Opisthorchis viverrini: A model of inflammation-mediated carcinogenesis. Nitric Oxide, 11: 175-183.
    CrossRef  |  

  53. Pinlaor, S., P. Mootsikapun, P. Pinlaor, A. Phunmanee and V. Pipitgool et al., 2004. PCR diagnosis of Pneumocystis carinii on sputum and bronchoalveolar lavage samples in immuno-compromised patients. Parasitol. Res., 94: 213-218.
    CrossRef  |  

  54. Pinlaor, S., N. Ma, Y. Hiraku, P. Yongvanit and R. Semba et al., 2004. Repeated infection with Opisthorchis viverrini induces accumulation of 8-nitroguanine and 8-oxo-7, 8-dihydro-2'-deoxyguanine in the bile duct of hamsters via inducible nitric oxide synthase. Carcinogenesis, 25: 1535-1542.
    CrossRef  |  Direct Link  |  

  55. Pinlaor, S., B. Sripa, P. Sithithaworn and P. Yongvanit, 2004. Hepatobiliary changes, antibody response, and alteration of liver enzymes in hamsters re-infected with Opisthorchis viverrini. Exp. Parasitol., 108: 32-39.
    CrossRef  |  

  56. Ma, N., Y. Adachi, Y. Hiraku, N. Horiki and S. Horiike, et al., 2004. Accumulation of 8-nitroguanine in human gastric epithelium induced by Helicobacter pylori infection. Biochem. Biophys. Res. Commun., 319: 506-510.
    CrossRef  |  

  57. Pinlaor, S., P. Yongvanit, Y. Hiraku, N. Ma and R. Semba et al., 2003. 8-Nitroguanine formation in the liver of hamsters infected with Opisthorchis viverrini. Biochem. Biophys. Res. Commun., 309: 567-571.
    CrossRef  |  

  58. Pinlaor, S., K. Ieamviteevanich, P. Pinlaor, W. Maleewong and V. Pipitgool, 2000. Seroprevalence of specific total immunoglobulin (Ig), IgG and IgM antibodies to Toxoplasma gondii in blood donors from Loei Province, Northeast Thailand. Southeast Asian J. Trop. Med. Public Health, 31: 123-127.
    Direct Link  |  

  59. Petmitr, S., S. Pinlaor, A. Thousungnoen, A. Karalak and P. Migasena, 1998. K-ras oncogene and p53 gene mutations in cholangiocarcinoma from Thai patients. Southeast Asian J. Trop. Med. Public Health, 29: 71-75.
    Direct Link  |  

  60. Srisawangwong, T., S. Pinlaor, P. Kanla and P. Sithithaworn, 1997. Centrocestus formosanus: Surface morphology of metacercaria, adult and egg. J. Helminthol., 71: 345-350.
    CrossRef  |