Dr. Ziganshin Ayrat
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Dr. Ziganshin Ayrat

Head of Academic Department/Faculty
Kazan State Medical University, Russia

Highest Degree
Ph.D. in Pharmacology from Kazan State Medical University, Russia

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Biography

Dr. Ziganshin Ayrat is currently working as Head of Department of Pharmacology at Kazan State Medical University, Russia, He has completed his Ph.D. in Pharmacology from same University. His main area of interest focuses on Pharmacology, Neurophysiology. His area of expertise includes ATP, Adenosine, Purinoceptors, Synapse, Smooth muscles, Vas Deferens, Autonomic Nervous System, Urinary Bladder, and New drugs. He has published 2 books, more than 92 research articles in journals contributed as author/co-author.

Area of Interest:

Pharmacology and Toxicology
100%
Neurophysiology
62%
Pharmacology
90%
Drug Delivery
75%
Medical Chemistry
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Grishin, S.N., A.Y. Teplov, A.M. Farhutdinov, B.A. Ziganshin and A.U. Ziganshin, 2013. Different effects of ATP on the contractility and nonquantal acetylcholine release of rat tonic and phasic muscles. Pharmacologia, 4: 519-524.
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  2. Ziganshina, A.P., B.A. Ziganshin and A.U. Ziganshin, 2012. Dual effects of ATP on isolated arteries of the bovine eye. Pharmacol. Res., 66: 170-176.
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  3. Kazakova, R.R., I.G. Mustafin, T.I. Mavludov, A.P. Kiyasov and A.U. Ziganshin, 2011. Expression of P2X receptor subtypes on CD34+ Cells and c-kit+ cells of human umbilical blood. Bull. Exp. Biol. Med., 151: 33-37.
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  4. Grishin, S.N., R.R. Kamaliev, A.Y. Teplov and A.U. Ziganshin, 2011. Opposite effect of ATP on contraction force of tonic and phasic skeletal muscles in frogs. Bull. Exp. Biol. Med., 151: 280-283.
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  5. Filimonova, A.A., L.E. Ziganshina, A.U. Ziganshin and A.A. Chichirov, 2011. New specific marker of cytochrome P450 1A2 activity. Bull. Exp. Biol. Med., 150: 762-764.
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  6. Ziganshina, L.E., R.R. Nyazov and A.U. Ziganshin, 2009. Biopharmaceuticals in the Russian Federation: A snapshot of policies for registration, reimbursement and use. Int. J. Risk Safety Med., 21: 75-88.
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  7. Ziganshin, A.U., R.R. Kamaliev, S.N. Grishin, B.A. Ziganshin and G. Burnstock, 2009. Interaction of hydrocortisone with ATP and adenosine on nerve-mediated contractions of frog skeletal muscle. Eur. J. Pharmacol., 607: 54-59.
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  8. Teplov, A.Y., S.N. Grishin, M.A. Mukhamedyarov, A.U. Ziganshin, A.L. Zefirov and A. Palotas, 2009. Ovalbumin-induced sensitization affects non-quantal acetylcholine release from motor nerve terminals and alters contractility of skeletal muscles in mice. Exp. Physiol., 94: 264-268.
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  9. Ziganshin, A.U., Z.R. Vafina and I.F. Fatkullin, 2008. Contrasting effects of P2 receptor agonists on spontaneous contractility of human fallopian tubes with and without acute inflammation. Pharmacol. Res., 57: 56-59.
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  10. Markovskaya, A., A. Crooke, A.I. Guzman-Aranguez, A. Peral and A.U. Ziganshin et al., 2008. Hypotensive effect of UDP on intraocular pressure in rabbits. Eur. J. Pharmacol., 579: 93-97.
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  11. Burashnikova, I.S., A.U. Ziganshin and L.E. Ziganshina, 2008. Attitudes to pharmaceutical promotion techniques among healthcare professionals in the Republic of Tatarstan, Russia. Int. J. Risk Safety Med., 20: 57-71.
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  12. Ziganshin, A.U., A.P. Zaitcev, A.A. Khasanov, A.F. Shamsutdinov and G. Burnstock et al., 2006. Term-dependency of P2 receptor-mediated contractile responses of isolated human pregnant uterus. Eur. J. Obstet.Gynecol. Reprod. Biol., 129: 128-134.
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  13. Grishin, S.N., A.Y. Teplov, A.V. Galkin, A.M. Devyataev and A.L. Zefirov et al., 2006. Different effects of ATP on the contractile activity of mice diaphragmatic and skeletal muscles. Neurochem. Int., 49: 756-763.
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  14. Ziganshin, A.U., R.R. Kamaliev, S.N. Grishin, L.E. Ziganshina, A.L. Zefirov and G. Burnstock, 2005. The influence of hypothermia on P2 receptor-mediated responses of frog skeletal muscle. Eur. J. Pharmacol., 509: 187-193.
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  15. Ziganshin, A.U., J.T. Zefirova, T.P. Zefirova, L.E. Ziganshina and C.H. Hoyle et al., 2005. Potentiation of uterine effects of prostaglandin F2alpha by adenosine 5'-triphosphate. Obstet. Gynecol., 105: 1429-1436.
    PubMed  |  
  16. Ziganshin, A.U., D.F. Khaziakhmetov, L.E. Ziganshina, V.N. Khaziakhmetova and R.K. Jourjikiya et al., 2004. Varicose disease affects the P2 receptor-mediated responses of human greater saphenous vein. Vasc. Pharmacol., 42: 17-21.
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  17. Burger, E.J., L. Ziganshina and A.U. Ziganshin, 2004. Academic medicine in Russia. Croat. Med. J., 45: 674-676.
    PubMed  |  
  18. Ziganshin, A.U., A.V. Rychkov, L.E. Ziganshina and G. Burnstock, 2002. Temperature dependency of P2 receptor-mediated responses. Eur. J. Pharmacol., 456: 107-114.
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  19. Zefirova, J.T., T.P. Zefirova, L.E. Ziganshina and A.U. Ziganshin, 2002. Effects of chronic specific urogenital infections on contractility of the human isolated pregnant myometrium. Autonomic Neurosci. Basic Clin., 99: 58-61.
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  20. Korthuis, P.T., L. Nekhlyudov, A.U. Ziganshin, M. Sadigh, and M.L. Green, 2002. Implementation of a cross-cultural evidence-based medicine curriculum. Med. Teacher, 24: 444-446.
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  21. Jacobson, K.A., C. Hoffmann, Y.C. Kim, E. Camaioni and E. Nandanan et al., 1999. Molecular recognition in P2 receptors: ligand development aided by molecular modeling and mutagenesis. Prog. Brain Res., 120: 119-132.
    PubMed  |  
  22. Kim, Y.C., E. Camaioni, A.U. Ziganshin, X. Ji and B.F. King et al., 1998. Synthesis and structure-activity relationships of pyridoxal-6-arylazo-5'-phosphate and phosphonate derivatives as P2 receptor antagonists. Drug Dev. Res., 45: 52-66.
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  23. Ziyal, R., A.U. Ziganshin, P. Nickel, U. Ardanuy and E. Mutschler et al., 1997. Vasoconstrictor responses via P2X-receptors are selectively antagonized by NF023 in rabbit isolated aorta and saphenous artery. Br. J. Pharmacol., 120: 954-960.
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  24. Ziganshin, A.U., L.E. Ziganshina and D.Z. Burnstok, 1997. Ecto-ATPases and receptors for ATP. Eksp Klin Farmakol., 60: 78-82.
    PubMed  |  
  25. Ziganshina, L.E., A.U. Ziganshin, C.H.V. Hoyle and G. Burnstock, 1996. Acute paw oedema formation induced by ATP: Re-evaluation of the mechanisms involved. Inflammation Res., 45: 96-102.
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  26. Ziganshin, A.U., L.E. Ziganshina, B.F. King, J. Pintor and G. Burnstock, 1996. Effects of P2-purinoceptor antagonists on degradation of adenine nucleotides by ecto-nucleotidases in folliculated oocytes of Xenopus laevis. Biochem. Pharmacol., 51: 897-901.
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  27. Ziganshin, A.U., L.E. Ziganshina, B.F. King and G. Burnstock, 1996. Differential degradation of extracellular adenine nucleotides by folliculated oocytes of Xenopus laevis. Comp. Biochem. Physiol. A: Physiol., 114: 335-340.
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  28. King, B.F., J. Pintor, S. Wang, A.U. Ziganshin and L.E. Ziganshina et al., 1996. A novel P1 purinoceptor activates an outward K+ current in follicular oocytes of Xenopus laevis. J. Pharmacol. Exp. Ther., 276: 93-100.
    PubMed  |  Direct Link  |  
  29. King, B.F., C. Dacquet, A.U. Ziganshin, D.F. Weetman and G. Bumstock et al., 1996. Potentiation by 2,2'-pyridylisatogen tosylate of ATP-responses at a recombinant P2Y1 purinoceptor. Br. J. Pharmacol., 117: 1111-1118.
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  30. Jarlebark, L., M. Erlandsson, A. Uri, B.F. King and A.U. Ziganshin et al., 1996. Peptidyl conjugates of adenosine 5'-carboxylic acid synthesized and evaluated as ligands for P2 purinoceptors. Biochem. Biophys. Res. Commun., 229: 363-369.
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  31. Hoyle, C.H.V., A.U. Ziganshin, J. Pintor and G. Burnstock, 1996. The activation of P1- and P2-purinoceptors in the guinea-pig left atrium by diadenosine polyphosphates. Br. J. Pharmacol., 118: 1294-1300.
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  32. Ziganshin, A.U., V. Ralevic and G. Burnstock, 1995. Contractility of urinary bladder and vas deferens after sensory denervation by capsaicin treatment of newborn rats. Br. J. Pharmacol., 114: 166-170.
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  33. Ziganshin, A.U., L.E. Ziganshina, C.H.V. Hoyle and G. Burnstock, 1995. Effects of divalent cations and La3+ on contractility and ecto-ATPase activity in the guinea-pig urinary bladder. Br. J. Pharmacol., 114: 632-639.
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  34. Ziganshin, A.U., L.E. Ziganshina, B.F. King and G. Burnstock, 1995. Characteristics of ecto-ATPase of Xenopus oocytes and the inhibitory actions of suramin on ATP breakdown. Pflugers Archiv, 429: 412-418.
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  35. Ziganshin, A.U., E.A. Berdnikov, L.E. Ziganshina, F.R. Tantasheva and C.H.V. Hoyle et al., 1995. Effects of α,β-unsaturated sulphones and phosphonium salts on ecto-ATPase activity and contractile responses mediated via P2χ-purinoceptors. Gen. Pharmacol. Vasc. Syst., 26: 527-532.
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  36. Windscheif, U., O. Pfaff, A.U. Ziganshin, C.H.V. Hoyle and H.G. Baumert et al., 1995. Inhibitory action of PPADS on relaxant responses to adenine nucleotides or electrical field stimulation in guinea-pig taenia coli and rat duodenum. Br. J. Pharmacol., 115: 1509-1517.
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  37. Ziganshin, A.U., C.H.V. Hoyle, L.E. Ziganshina and G. Burnstock, 1994. Effects of cyclopiazonic acid on contractility and ecto-ATPase activity in guinea-pig urinary bladder and vas deferens. Br. J. Pharmacol., 113: 669-674.
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  38. Ziganshin, A.U., C.H.V. Hoyle, G. Lambrecht, E. Mutschler and H.G. Baumert et al., 1994. Selective antagonism by PPADS at P2X-purinoceptors in rabbit isolated blood vessels. Br. J. Pharmacol., 111: 923-929.
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  39. Ziganshin, A.U., C.H.V. Hoyle and G. Burnstock, 1994. Ecto-enzymes and metabolism of extracellular ATP. Drug Dev. Res., 32: 134-146.
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  40. Burnstock, G., B. Fischer, C.H.V. Hoyle, M. Maillard and A.U. Ziganshin et al., 1994. Structure activity relationships for derivatives of adenosine-5'-triphosphate as agonists at P2 purinoceptors: Heterogeneity within P2x and P2y subtypes. Drug Dev. Res., 31: 206-219.
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  41. Ziganshin, A.U., C.H.V. Hoyle, X. Bo, G. Lambrecht, E. Mutschler, H.G. Baumert and G. Burnstock, 1993. PPADS selectively antagonizes P2X-purinoceptor-mediated responses in the rabbit urinary bladder. Br. J. Pharmacol., 110: 1491-1495.
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  42. Fischer, B., J.L. Boyer , C.H.V. Hoyle , A.U. Ziganshin and A.L. Brizzolara et al., 1993. Identification of potent, selective P2γ-purinoceptor agonists: structure-activity relationships for 2-thioether derivatives of adenosine 5'-triphosphate. J. Med. Chem., 36: 3937-3946.
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  43. Ziganshin, A.U., I.A. Studentsova and I.V. Zaikonnikova, 1988. Effect of dimephosphon on the adenine nucleotide system. Farmakol Toksikol., 51: 80-82.
    PubMed  |