Hi, I am Kiyotsugu Yoshida, My LiveDNA is 81.6348
 
   
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Dr. Kiyotsugu Yoshida
 
Highest Degree: Ph.D. in Biochemistry from The Jikei University School of Medicine, Japan
 
Institute: The Jikei University School of Medicine, Japan
 
Area of Interest: Chemistry
  •   Signal Transduction
  •   DNA Damage
  •   Apoptosis
  •   Anticancer Drugs
 
URL: http://livedna.org/81.6348
 
My SELECTED Publications
1:   Abbas, T., D. White, L. Hui, K. Yoshida, D.A. Foster and J. Bargonetti, 2004. Inhibition of human p53 basal transcription by down-regulation of protein kinase C δ. J. Biol. Chem., 279: 9970-9977.
PubMed  |  Direct Link  |  
2:   Datta, R., H. Kojima, K. Yoshida and D. Kufe, 1997. Caspase-3-mediated cleavage of protein kinase C q in induction of apoptosis. J. Biol. Chem., 272: 20317-20320.
3:   Endo, K., E. Oki, V. Biedermann, H. Kojima and K. Yoshida, 2000. Proteolytic cleavage and activation of protein kinase C μ by caspase-3 in the apoptotic response of cells to 1-β-d-arabinofuranosylcytosine and other genotoxic agents. J. Biol. Chem., 275: 18476-18481.
CrossRef  |  
4:   Hew, H.C., H. Liu, Z.G. Lu, J. Kimura, Y. Miki and K. Yoshida, 2011. Identification of Evi-1 as a novel effector of PKCδ in the apoptotic response to DNA damage. Biochim. Biophys. Acta, 1803: 285-294.
PubMed  |  
5:   Hewm, H.C., H. Liu, Y. Miki and K. Yoshida, 2011. PKCδ regulates Mdm2 independently of p53 in the apoptotic response to DNA damage. Mol. Carcinog., 50: 719-731.
6:   Huang, Y., S. Nakada, T. Ishiko, T. Utsugisawa and R. Datta et al., 1999. Role for caspase-mediated cleavage of Rad51 in induction of apoptosis by DNA damage. Mol. Cell. Biol., 19: 2986-2997.
PubMed  |  
7:   Ito, Y., N.C. Mishra, K. Yoshida, S. Kharbanda, S. Saxena and D. Kufe, 2001. Mitochondrial targeting of JNK/SAPK in the phorbol ester response of myeloid leukemia cells. Cell Death Differ., 8: 794-800.
PubMed  |  
8:   Joki, T., M. Nakamura, K. Yoshida, S. Kunimoto, Y. Namiki, T. Abe and T. Ohno, 1996. Modification of doxorubicin molecule enhanced the early growth response gene 1 promoter activity. Jikeikai Med. J., 43: 1-7.
9:   Kaneki, M., S. Kharbanda, P. Pandey, K. Yoshida and M. Takekawa et al., 1999. Functional role for protein kinase C β as a regulator of stress-activated protein kinase activation and monocytic differentiation of myeloid leukemia cells. Mol. Cell. Biol., 19: 461-470.
PubMed  |  
10:   Kharbanda, S., P. Pandey, L. Schofield, S. Israels and R. Roncinske et al., 1997. Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis. Proc. Natl. Acad. Sci. USA., 94: 6939-6942.
PubMed  |  
11:   Kharbanda, S., S. Saxena, K. Yoshida, P. Pandey and M. Kaneki et al., 2000. Translocation of sapk/jnk to mitochondria and interaction with bcl-xl in response to dna damage. J. Biol. Chem., 275: 322-327.
CrossRef  |  
12:   Kimura, J., S.T. Nguyen, H. Liu, N. Taira, Y. Miki and K. Yoshida, 2008. A functional genome-wide RNAi screen identifies TAF1 as a regulator for apoptosis in response to genotoxic stress. Nucleic Acids Res., 36: 5250-5259.
PubMed  |  
13:   Kimura, J., T. Kudoh, Y. Miki and K. Yoshida, 2011. Identification of dihydropyrimidinase-related protein 4 as a novel target of the p53 tumor suppressor in the apoptotic response to DNA damage. Int. J. Cancer, 128: 1524-1531.
PubMed  |  
14:   Kudoh, T., J. Kimura, Z.G. Lu, Y. Miki and K. Yoshida, 2010. D4S234E, a novel p53-responsive gene, induces apoptosis in response to DNA damage. Exp. Cell Res., 315: 2849-2858.
PubMed  |  
15:   Li, Y., W. Chen, J. Ren, W. Yu, Q. Li, K. Yoshida and D. Kufe, 2003. DF3/MUC1 signaling in multiple myeloma cells is regulated by Interleukin-7. Cancer Biol. Ther., 2: 187-193.
PubMed  |  
16:   Liu, H., H.C. Hew, Z.G. Lu, T. Yamaguchi, Y. Miki and K. Yoshida, 2009. DNA damage signalling recruits RREB-1 to the p53 tumor suppressor promoter. Biochem. J., 422: 543-551.
PubMed  |  
17:   Liu, H., Z.G. Lu, Y. Miki and K. Yoshida, 2007. Protein kinase C δ induces transcription of the TP53 tumor suppressor by controlling death-promoting factor Btf in the apoptotic response to DNA damage. Mol. Cell. Biol., 27: 8480-8491.
PubMed  |  
18:   Lu, Z.G., H. Liu, T. Yamaguchi, Y. Miki and K. Yoshida, 2009. Protein kinase Cd activates RelA/p65 and nuclear factor-kB signaling in response to tumor necrosis factor-a. Cancer Res., 69: 5927-5935.
Direct Link  |  
19:   Mimoto, R., N. Taira, H. Takahashi, T. Yamaguchi and M. Okabe et al., 2013. DYRK2 controls the epithelial-mesenchymal transition in breast cancer by degrading Snail. Cancer Lett., 339: 214-225.
PubMed  |  
20:   Nakamura, M., H. Okada, H. Sasaki, K. Yoshida and M. Kamada et al., 1996. Quantification of the CD55 and CD59, membrane inhibitors of complement on HIV-1 particles as a function of complement-mediated virolysis. Microbiol. Immunol., 40: 561-567.
PubMed  |  
21:   Nakamura, M., K. Yoshida, M. Yoshida, S. Kunimoto, T. Takeuchi and T. Ohno, 1995. Eulicin inhibits human immunodeficiency virus infection and replication. J. Antibiot., 48: 1362-1363.
PubMed  |  
22:   Nakamura, M., M. Terada, K. Matsuzaki, K. Yoshida and T. Ohno, 2001. Mechanism of inhibitory effect of NCC164 on replication of human immunodeficiency virus. Microbiol. Immunol., 45: 217-223.
PubMed  |  
23:   Nihira, K., N. Taira, Y. Miki and K. Yoshida, 2008. TTK/Mps1 controls nuclear targeting of c-Abl by 14-3-3-coupled phosphorylation in response to oxidative stress. Oncogene, 27: 7285-7295.
PubMed  |  
24:   Nihira, K., Y. Ando, T. Yamaguchi, Y. Kagami, Y. Miki and K. Yoshida, 2010. Pim1 controls NF-κB signalling by stabilizing RelA/p65. Cell Death Differ., 17: 689-698.
25:   Raina, D., R. Ahmad, S. Kumar, J. Ren, K. Yoshida, S. Kharbanda and D. Kufe, 2006. MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage. EMBO J., 25: 3774-3783.
Direct Link  |  
26:   Ren, X., C. Cao, L. Zhu, K. Yoshida, S. Kharbanda, R. Weichselbaum and D. Kufe, 2002. Lyn tyrosine kinase inhibits nuclear export of the p53 tumor suppressor. Cancer Biol. Ther., 1: 703-708.
PubMed  |  
27:   Shinagawa, H., Y. Miki and K. Yoshida, 2008. BRCA1-mediated ubiquitination inhibits topoisomerase IIa activity in response to oxidative stress. Antioxid. Redox. Signal., 10: 939-950.
PubMed  |  
28:   Sobota, A., A. Strzelecka-Kiliszek, E. Gadkowska, K. Yoshida, K. Mrozinska and K. Kwiatkowska, 2005. Binding of IgG-opsonized particles to FcgR is an active stage of phagocytosis which involves receptor clustering and phosphorylation. J. Immunol., 175: 4450-4457.
29:   Suzuki, K., N. Dashzeveg, Z.G. Lu, N. Taira, Y. Miki and K. Yoshida, 2012. 2012. PDCD6, a novel p53-responsive gene, targets to the nucleus in the apoptotic response to DNA damage. Cancer Sci., 103: 1788-1894.
PubMed  |  
30:   Taira, N. and K. Yoshida, 2012. Post-translational modifications of p53 tumor suppressor: Determinants of its functional targets. Histol. Histopathol., 27: 437-443.
PubMed  |  
31:   Taira, N., H. Yamamoto, T. Yamaguchi, Y. Miki and K. Yoshida, 2010. ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage. J. Biol. Chem., 285: 4909-4919.
PubMed  |  
32:   Taira, N., K. Nihira, T. Yamaguchi, Y. Miki and K. Yoshida, 2007. DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. Mol. Cell, 25: 725-738.
PubMed  |  
33:   Taira, N., R. Mimoto, M. Kurata, T. Yamaguchi, M. Kitagawa, Y. Miki and K. Yoshida, 2012. DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells. J. Clin. Invest., 122: 859-872.
PubMed  |  
34:   Tomiyoshi, G., A. Nakanishi, K. Takenaka, K. Yoshida and Y. Miki, 2008. A novel BRCA2-interacting protein BJ-HCC-20A inhibits the induction of apoptosis in response to DNA damage. Cancer Sci., 99: 747-754.
PubMed  |  
35:   Xu, H., H. Zhao, W. Tian, K. Yoshida, J.B. Roullet and D.M. Cohen, 2003. Regulation of a TRP channel by tyrosine phosphorylation: Src family kinase-dependent phosphorylation of TRPV4 on Y253 mediates its response to hypotonic stress. J. Biol. Chem., 278: 11520-11527.
36:   Yamaguchi, T., J. Kimura, Y. Miki and K. Yoshida, 2007. The USP11 deubiquitinating enzyme controls an IkB kinase a (IKKa)-p53 signaling pathway in response to tumor necrosis factor a (TNFa). J. Biol. Chem., 282: 33943-33948.
PubMed  |  
37:   Yamaguchi, T., Y. Miki and K. Yoshida, 2007. Protein kinase C d activates IkB-kinase a to induce the p53 tumor suppressor in response to oxidative stress. Cell. Signal., 19: 2088-2097.
38:   Yamaguchi, T., Y. Miki and K. Yoshida, 2010. The c-Abl tyrosine kinase stabilizes Pitx1 in the apoptotic response to DNA damage. Apoptosis, 15: 927-935.
PubMed  |  
39:   Yoshida, K. and D. Kufe, 2001. Negative regulation of the SHPTP1 tyrosine phosphatase by protein kinase Cδ in response to DNA damage. Mol. Pharmacol., 60: 1431-1438.
PubMed  |  
40:   Yoshida, K. and Y. Miki, 2004. Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription and cell cycle in response to DNA damage. Cancer Sci., 95: 866-871.
PubMed  |  
41:   Yoshida, K. and Y. Miki, 2005. Enabling death by the Abl Tyrosine kinase: Mechanisms for nuclear shuttling of c-Abl in response to DNA damage. Cell Cycle, 4: 777-779.
PubMed  |  
42:   Yoshida, K. and Y. Miki, 2010. The cell death machinery governed by the p53 tumor suppressor in response to DNA damage. Cancer Sci., 101: 831-835.
PubMed  |  
43:   Yoshida, K., 2007. PKCδ signaling: Mechanisms of DNA damage response and apoptosis. Cell. Signal., 19: 892-901.
PubMed  |  
44:   Yoshida, K., 2007. Protein Kinase C d: The Determinant for Cell Fate in Response to DNA Damage. In: New Developments in Cell Apoptosis Research, Valentino, R.G. (Ed.). Nova Science Publishers, New York, pp: 97-120.
45:   Yoshida, K., 2008. Nuclear trafficking of pro-apoptotic kinases in response to DNA damage. Trends. Mol. Med., 14: 305-313.
PubMed  |  
46:   Yoshida, K., 2008. Role for DYRK family kinases on regulation of apoptosis. Biochem. Pharmacol., 76: 1389-1394.
PubMed  |  
47:   Yoshida, K., 2011. Molecular Function of the p53 Tumor Suppressor in the Apoptotic Response to DNA Damage. In: Tumor Suppressors, Nguyen, S.D. (Ed.). Nova Science Publishers, New York, pp: 229-242.
48:   Yoshida, K., 2011. Role for PKCδ on Apoptosis in the DNA Damage Response. In: Selected Topics in DNA Repair, Chen, C.C. (Ed.). InTech, USA., pp: 293-304.
49:   Yoshida, K., 2012. Functional Role for the c-Abl Tyrosine Kinase Signalling in the DNA Damage Response. In: DNA Repair: New Research, Kimura, S. and S. Shimizu (Eds.). Nova Science Publishers, New York, pp: 133-147.
50:   Yoshida, K., H. Liu and Y. Miki, 2006. Protein kinase C δ regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage. J. Biol. Chem., 281: 5734-5740.
PubMed  |  
51:   Yoshida, K., H.G. Wang, Y. Miki and D. Kufe, 2003. Protein kinase Cδ is responsible for constitutive and DNA damage-induced phosphorylation of Rad9. EMBO J., 22: 1431-1441.
52:   Yoshida, K., K. Komatsu, H.G. Wang and D. Kufe, 2002. c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage. Mol. Cell. Biol., 22: 3292-3300.
PubMed  |  
53:   Yoshida, K., M. Nakamura and T. Ohno, 1997. Mutations of the HIV type 1 V3 loop under selection pressure with neutralizing monoclonal antibody NM-01. AIDS Res. Hum. Retroviruses, 13: 1283-1290.
PubMed  |  
54:   Yoshida, K., R. Weichselbaum, S. Kharbanda and D. Kufe, 2000. Role for Lyn tyrosine kinase as a regulator of stress-activated protein kinase activity in response to DNA damage. Mol. Cell. Biol., 20: 5370-5380.
PubMed  |  
55:   Yoshida, K., S. Kharbanda and D. Kufe, 1999. Functional interaction between SHPTP1 and the Lyn tyrosine kinase in the apoptotic response to DNA damage. J. Biol. Chem., 274: 34663-34668.
PubMed  |  
56:   Yoshida, K., T. Yamaguchi, H. Shinagawa, N. Taira, K.I. Nakayama and Y. Miki, 2006. Protein kinase C δ activates topoisomerase IIα to induce apoptotic cell death in response to DNA damage. Mol. Cell. Biol., 26: 3414-3431.
PubMed  |  
57:   Yoshida, K., T. Yamaguchi, T. Natsume, D. Kufe and Y. Miki, 2005. JNK phosphorylation of 14-3-3 regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. Nat. Cell Biol., 7: 278-285.
PubMed  |  
58:   Yoshida, K., Y. Miki and D. Kufe, 2002. Activation of SAPK/JNK signaling by protein kinase C δ in response to DNA damage. J. Biol. Chem., 277: 48372-48378.
PubMed  |