Hi, I am Toshio Tanaka, My LiveDNA is 81.6449
 
   
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Dr. Toshio Tanaka
 
Highest Degree: Ph.D. in Internal Medicine from Osaka University, Japan
 
Institute: Osaka University Graduate School of Medicine, Japan
 
Area of Interest: Medicine
  •   Ageing Mechanisms
  •   Immunology
  •   Arthritis Rheumatism
  •   Internal Medicine
 
URL: http://livedna.org/81.6449
 
My SELECTED Publications
1:   Arimitsu, J., T. Hirano, S. Higa, M. Kawai and T. Naka et al., 2006. IL-18 gene polymorphisms affect IL-18 production capability by monocytes. Biochem. Biophys. Res. Commun., 342: 1413-1416.
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2:   Arnaud, L., H. Devilliers, S.L. Peng, A. Mathian and N. Costedoat-Chalumeau et al., 2012. The relapsing polychondritis disease activity index: Development of a disease activity score for relapsing polychondritis. Autoimmun. Rev., 12: 204-209.
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3:   Doi, S., O. Saiki, T. Hara, T. Sugita and K. Ha-Kawa et al., 1989. Administration of recombinant IL-2 augments the level of serum IgM in an IL-2 deficient patient. Eur. J. Pediatrics, 148: 630-633.
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4:   Doi, S., O. Saiki, T. Tanaka, K. Ha-Kawa and T. Igarashi et al., 1988. Cellular and genetic analyses of IL-2 production and IL-2 receptor expression in a patient with familial T-cell-dominant immunodeficiency. Clin. Immunol. Immunopathol., 46: 24-36.
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5:   Hagihara, K., I. Kawase, T. Tanaka and T. Kishimoto, 2010. Tocilizumab ameliorates clinical symptoms in polymyalgia rheumatica. J. Rheumatol., 37: 1075-1076.
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6:   Hagihara, K., T. Nishikawa, A. Matsumura, J. Song, T. Tanaka and K. Yoshizaki, 2006. Analysis of cytokine-driven serum amyloid A expression based on the clinical results of IL-6 blocking therapy: A new cis-acting mechanism of STAT3. Inflammation Regenr., 26: 453-459.
7:   Hara, H., S. Negoro, S. Miyata, O. Saiki and K. Yoshizaki et al., 1987. Age-associated changes in proliferative and differentiative response of human B cells and production of T cell-derived factors regulating B cell functions. Mech. Ageing Dev., 38: 245-258.
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8:   Hara, H., T. Tanaka, S. Negoro, Y. Deguchi, S. Nishio, O. Saiki and S. Kishimoto, 1988. Age-related changes of expression of IL-2 receptor subunits and kinetics of IL-2 internalization in T cells after mitogenic stimulation. Mech. Ageing Dev., 45: 167-175.
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9:   Harigai, M., Y. Tanaka, S. Maisawa and The JA21963 Study Group, 2012. Safety and efficacy of various dosages of ocrelizumab in Japanese patients with rheumatoid arthritis with an inadequate response to methotrexate therapy: A placebo-controlled double-blind parallel-group study. J. Rheumatol., 39: 486-495.
CrossRef  |  PubMed  |  Direct Link  |  
10:   Hayashi, N., T. Yoshimoto, K. Izuhara, K. Matsui, T. Tanaka and K. Nakanishi, 2007. T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-γ and IL-13 production. Proc. Natl. Acad. Sci., 104: 14765-14770.
PubMed  |  
11:   He, P., T. Naka, S. Serada, M. Fujimoto and T. Tanaka et al., 2007. Proteomics-based identification of α-enolase as a tumor antigen in non-small lung cancer. Cancer Sci., 98: 1234-1240.
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12:   Higa, H., H. Hirata, S. Minami, S. Hashimoto, M. Suemura, Y. Saeki, I. Kawase and T. Tanaka, 2002. Autoimmune acquired form of angioedema that responded to danazol therapy. Intern. Med., 41: 398-402.
PubMed  |  
13:   Higa, S., M. Kotani, M. Matsumoto, A. Fujita and T. Hirano et al., 2003. Administration of anti-interleukin 18 antibody fails to inhibit development of dermatitis in atopic dermatitis-model mice NC/Nga. Br. J. Dermatol., 149: 39-45.
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14:   Higa, S., T. Hirano, M. Kotani, M. Matsumoto and A. Fujita et al., 2003. Fisetin, a flavonol, inhibits TH2-type cytokine production by activated human basophils. J. Allergy Clin. Immunol., 111: 1299-1306.
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15:   Higa, S., T. Hirano, M. Mayumi, M. Hiraoka and Y. Ohshima et al., 2003. Association between interleukin-18 gene polymorphism 105A/C and asthma. Clin. Exp. Allergy, 33: 1097-1102.
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16:   Hirano, T., J. Arimitsu, S. Higa, T. Naka and A. Ogata et al., 2004. Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils. Int. Arch. Allergy Immunol., 134: 135-140.
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17:   Hirano, T., J. Arimitsu, S. Higa, T. Naka and A. Ogata et al., 2006. Luteolin, a flavonoid, inhibits CD40 ligand expression by activated human basophils. Int. Arch. Allergy Immunol., 140: 150-156.
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18:   Hirano, T., M. Kawai, J. Arimitsu, M. Ogawa and Y. Kuwahara et al., 2009. Preventative effect of a flavonoid, enzymatically modified isoquercitrin on ocular symptoms of Japanese cedar pollinosis. Allergol. Int., 58: 373-382.
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19:   Hirano, T., N. Ohguro, S. Hohki, K. Hagihara and Y. Shima et al., 2012. A case of Behcet's disease treated with a humanized Anti-interleukin-6 receptor antibody, tocilizumab. Modern Rheumatol., 22: 298-302.
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20:   Hirano, T., S. Higa, J. Arimitsu, T. Naka and A. Ogata et al., 2006. Luteolin, a flavonoid, inhibits AP-1 activation by basophils. Biochem. Biophys. Res. Commun., 340: 1-7.
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21:   Hishitani, Y., A. Ogata, Y. Shima, T. Hirano and K. Ebina et al., 2013. Retention of tocilizumab and anti-tumour necrosis factor drugs in the treatment of rheumatoid arthritis. Scand. J. Rheumatol., 42: 253-259.
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22:   Inaba, M., H. Saito, M. Fujimoto, S. Sumitani and T. Ohkawara et al., 2005. Suppressor of cytokine signaling 1 suppresses muscle differentiation through modulation of IGF-I receptor signal transduction. Biochem. Biophys. Res. Commun., 328: 953-961.
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23:   Iwashige, K., K. Kouda, M. Kouda, K. Horiuchi and M. Takahashi et al., 2004. Calorie restricted diet and urinary pentosidine in patients with rheumatoid arthritis. J. Physiol. Anthropol. Appl. Human Sci., 23: 19-24.
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24:   Jiang, M., H. Tsukahara, Y. Ohshima, C. Zou and N. Ohta et al., 2004. Methylenetetrahydrofolate reductase polymorphism in patients with bronchial asthma. Int. Med. J., 11: 119-123.
25:   Kasayama, S., T. Tanaka, K. Hashimoto, M. Koga and I. Kawase, 2002. Efficacy of glimepiride for the treatment of diabetes occurring during glucocorticoid therapy. Diabetes Care, 25: 2359-2360.
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26:   Katada, Y., T. Tanaka, H. Ochi, M. Aitani and A. Yokota et al., 1996. B cell-B cell interaction through intercellular adhesion molecule-1 and lymphocyte functional antigen-1 regulates immunoglobulin E synthesis by B cells stimulated with interleukin-4 and anti-CD40 antibody. Eur. J. Immunol., 26: 192-200.
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27:   Katada, Y., Y. Harada, N. Azuma, K. Matsumoto and H. Terada et al., 2006. Minocycline-induced vasculitis fulfilling the criteria of polyarteritis nodosa. Mod. Rheumatol., 16: 256-259.
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28:   Kawai, M., K. Hagihara, T. Hirano, Y. Shima and Y. Kuwahara et al., 2009. Sustained response to tocilizumab, anti-interleukin-6 receptor antibody, in two patients with refractory relapsing polychondritis. Rheumatology, 48: 318-319.
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29:   Kawai, M., T. Hirano, J. Arimitsu, S. Higa and Y. Kuwahara et al., 2009. Effect of enzymatically modified isoquercitrin, a flavonoid, on symptoms of Japanese cedar pollinosis: A randomized double-blind placebo-controlled trial. Int. Arch. Allergy Immunol., 149: 359-368.
CrossRef  |  PubMed  |  
30:   Kawai, M., T. Hirano, S. Higa, J. Arimitsu and M. Maruta et al., 2007. Flavonoids and related compounds as anti-allergic substances. Allergol. Int., 56: 113-123.
PubMed  |  Direct Link  |  
31:   Kitaba, S., H. Murota, M. Terao, H. Azukizawa and F. Shima et al., 2012. Blockade of interleukin-6 receptor alleviates disease in mouse model of scleroderma. Am. J. Pathol., 180: 165-176.
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32:   Kotani, M., M. Matsumoto, A. Fujita, S. Higa, W. Wang, M. Suemura, T. Kishimoto and T. Tanaka, 2000. Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice. J. Allergy Clin. Immunol., 106: 159-166.
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33:   Kouda, K., T. Tanaka, M. Kouda, H. Takeuchi, A. Takeuchi, H. Nakamura and M. Takigawa, 2000. Low-energy diet in atopic dermatitis patients: clinical findings and DNA damage. J. Physiol. Anthropol. Appl. Human Sci., 19: 225-228.
PubMed  |  Direct Link  |  
34:   Kudo-Tanaka, E., S. Nakatsuka, T. Hirano, M. Kawai and Y. Katada et al., 2009. A case of Mikulicz's disease with Th2-biased cytokine profile: Possible feature discriminable from Sjogren's syndrome. Modern Rheumatol., 19: 691-695.
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35:   Kuwahara, Y., Y. Shima, D. Shirayama, M. Kawai and K. Hagihara et al., 2008. Quantification of hardness, elasticity and viscosity of the skin of patients with systemic sclerosis using a novel sensing device (Vesmeter): A proposal for a new outcome measurement procedure. Rheumatology, 47: 1018-1024.
PubMed  |  
36:   Kuwahara, Y., Y. Shima, M. Kawai, K. Hagihara and T. Hirano et al., 2008. What kind of durometer is best suited for the assessment of skin disease in systemic sclerosis? Comment on the article by Kissin et al? Arthritis Rheum, Vol. 59. 10.1002/art.23543.
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37:   Kuwahara, Y., Y. Shima, T. Tanaka, H. Kimura, Y. Hoshida, K. Aozasa and I. Kawase, 2006. Successful treatment with intravenous cyclophosphamide pulse therapy of severe intestinal involvement in Wegener's granulomatosis. Scand J. Rheumatol., 35: 243-245.
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38:   Maeda, K., T. Tanaka, Y. Katada, A. Horii and K. Nose et al., 1998. Bronchial and nasal responsiveness in atopic asthma and allergic rhinitis patients: relationship of local responsiveness to cytokine production by peripheral blood mononuclear cells. Allergol. Int., 47: 45-51.
39:   Matsumoto, M. Kotani, A. Fujita, S. Higa, T. Kishimoto, M. Suemura and T. Tanaka, 2002. Oral administration of persimmon leaf extract ameliorates skin symptoms and transepidermal water loss in atopic dermatitis model mice, NC/Nga. Br. J. Dermatol., 146: 221-221.
40:   Matsumoto, T., T. Tanaka and I. Kawase, 2006. Infliximab for rheumatoid arthritis in a patient with tuberculosis. N. Engl. J. Med., 355: 740-741.
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41:   Matsuzaki, N., F. Saji, T. Okada, K. Sawai and T. Kameda et al., 1989. Demonstration of functional immaturity of signal transduction pathways in human cord T cells. Cellular Immunol., 124: 252-263.
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42:   Miyasaka, N., 2008. Clinical investigation in highly disease-affected rheumatoid arthritis patients in Japan with adalimumab applying standard and general evaluation: The CHANGE study. Mod. Rheumatol., 18: 252-262.
43:   Nakaoka, Y., K. Higuchi, Y. Arita, M. Otsuki and K. Yamamoto et al., 2013. Tocilizumab for the treatment of the patients with refractory Takayasu arteritis. Int. Heart J., 54: 405-411.
PubMed  |  Direct Link  |  
44:   Narazaki, M., K. Hagihara, Y. Shima, A. Ogata, T. Kishimoto and T. Tanaka, 2011. Therapeutic effect of tocilizumab on two patients with polymyositis. Rheumatology, 50: 1344-1346.
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45:   Narazaki, M., M. Segarra, X. Hou, T. Tanaka, X. Li and G. Tosato, 2010. Oligo-guanosinenucleotide induces Neutropilin-1 internalization in endothelial cells and inhibits angiogenesis. Blood, 116: 3099-3107.
46:   Negoro, S., H. Hara, S. Miyata, O. Saiki and T. Tanaka et al., 1986. Mechanisms of age-related decline in antigen-specific T cell proliferative response: IL-2 receptor expression and recombinant IL-2 induced proliferative response of purified Tac-positive T cells. Mech. Ageing Dev., 36: 223-241.
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47:   Negoro, S., H. Hara, S. Miyata, O. Saiki and T. Tanaka et al., 1987. Age-related changes of the function of T cell subsets: Predominant defect of the proliferative response in CD8 positive T cell subset in aged persons. Mech. Ageing Dev., 39: 263-279.
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48:   Nishida, S., K. Hagihara, Y. Shima, M. Kawai and Y. Kuwahara et al., 2009. Rapid improvement of AA amyloidosis with humanised anti-interleukin 6 receptor antibody treatment. Ann. Rheumat. Dis., 68: 1235-1236.
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49:   Nishida, S., T. Kawasaki, H. Kashiwagi, A. Morishima and Y. Hishitani et al., 2011. Successful treatment of acquired hemophilia A, complicated by chronic GVHD, with tocilizumab. Modern Rheumatol., 21: 420-422.
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50:   Nishikawa, T., K. Hagihara, S. Serada, T. Isobe and A. Matsumura et al., 2008. Transcriptional complex formation of c-Fos, STAT3, and hepatocyte NF-1 alpha is essential for cytokine-driven C-reactive protein gene expression. J. Immunol., 180: 3492-3501.
PubMed  |  
51:   Nishio, S.I., S. Negoro, T. Hosokawa, H. Hara and T. Tanaka et al., 1990. The effect of taurine on age-related immune decline in mice: the effect of taurine on T cell and B cell proliferative response under costimulation with ionomycin and phorbol myristate acetate. Mech. Ageing Dev., 52: 125-139.
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52:   Ochi, H., T. Tanaka, Y. Katada, T. Naka and M. Aitani et al., 1996. Functional disturbance of naive T lymphocytes in very high IgE producers: Depletion of interleukin-4-induced interleukin-4-producing cells. Int. Arch. Allergy Immunol., 109: 236-242.
PubMed  |  Direct Link  |  
53:   Ochi, H., T. Tanaka, Y. Katada, T. Naka and M. Aitani et al., 1996. Peripheral blood T lymphocytes and basophils, freshly isolated from house-dust-mite-sensitive patients, produce lnterleukin-4 in response to allergen-specific stimulation. Int. Arch. Allergy Immunol., 111: 253-261.
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54:   Ogata, A. and T. Tanaka, 2012. Tocilizumab for the treatment of rheumatoid arthritis and other systemic autoimmune diseases: Current perspectives and future directions. Int. J. Rheumatol., 10.1155/2012/946048.
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55:   Ogata, A., A. Kumanogoh and T. Tanaka, 2012. Pathological role of interleukin-6 in psoriatic arthritis. Arthritis, Vol. 2012. 10.1155/2012/713618.
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56:   Ogata, A., A. Morishima, T. Hirano, Y. Hishitani and K. Hagihara et al., 2011. Improvement of HbA1c during treatment with humanised Anti-interleukin 6 receptor antibody, tocilizumab. Ann. Rheumatic Dis., 70: 1164-1165.
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57:   Ogata, A., A. Morishima, Y. Yoshida, T. Tanaka and A. Kumanogoh, 2013. IL-6 Targeting Strategy for Rheumatoid Arthritis. In: Interleukin-6: Genetics, Clinical Applications and Role in Disease, D'Aquino, J. and E.N. DeVito (Eds.). Chapter 3, Nova Science Publishers, USA., pp: 111-149.
58:   Ogata, A., K. Tanimura, T. Sugimoto, T. Inoue and Y. Urata et al., 2013. A phase 3 study of the efficacy and safety of subcutaneous versus intravenous tocilizumab monotherapy in patients with rheumatoid arthritis (MUSASHI). Arthritis Care Res., (In Press). 10.1002/acr.22110.
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59:   Ogata, A., M. Mori, S. Hashimoto, Y. Yano and T. Fujikawa et al., 2010. Minimal influence of tocilizumab on IFN-γ synthesis by tuberculosis antigens. Modern Rheumatol., 20: 130-133.
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60:   Ogata, A., N. Umegaki, I. Katayama, A. Kumanogoh and T. Tanaka, 2012. Psoriatic arthritis in two patients with an inadequate response to treatment with tocilizumab. Joint Bone Spine, 79: 85-87.
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61:   Ogata, A., T. Hirano, Y. Hishitani and T. Tanaka, 2012. Safety and efficacy of tocilizumab for the treatment of rheumatoid arthritis. Clin. Med. Insights Arthritis Musculoskelet. Disord., 5: 27-42.
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62:   Ogata, A., T. Tanaka and A. Kumanogoh, 2013. Efficacy of Anti-IL-6 Therapy for Seronegative Spondyloarthropathy. In: Ankylosing Spondylitis: Symptoms, Treatment and Potential Complications, Boysen, C.B. (Ed.). Chap. 2, Nova Science Publishers Inc., New York, pp: 37-52.
63:   Ogata, F.T., K. Nakanishi, M. Kawai, Y. Kuwahara and T. Hirano et al., 2009. Etanercept improved primary biliary cirrhosis associated with rheumatoid arthritis. Joint. Bone. Spine, 76: 105-107.
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64:   Ogawa, M., T. Matsuda, A. Ogata, T. Hamasaki, A. Kumanogoh, T. Toyofuku and T. Tanaka, 2013. DNA damage in rheumatoid arthritis: An age-dependent increase in the lipid peroxidation-derived DNA adduct, heptanone-etheno-2-deoxycytidine. Autoimmune Dis., (In Press). 10.1155/2013/183487.
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65:   Ohshima, S., Y. Saeki, T. Mima, M. Sasai and K. Nishioka et al., 1998. Interleukin 6 plays a key role in the development of antigen-induced arthritis. Proc. Natl. Acad. Sci., 95: 8222-8226.
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66:   Ohta, K., T. Miyamoto, T. Amagasaki and M. Yamamoto, 2009. Efficacy and safety of omalizumab in an Asian population with moderate-to-severe persistent asthma. Respirology, 14: 1156-1165.
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67:   Oji, Y., Y. Oka, S. Nishida, A. Tsuboi and M. Kawakami et al., 2010. WT1 peptide vaccine induces reduction in minimal residual disease in an Imatinib-treated CML patient. Eur. J. Haematol., 85: 358-360.
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68:   Ouyang, X., M. Fujimoto, R. Nakagawa, S. Serada and T. Tanaka et al., 2006. SOCS-2 interferes with myotube formation and potentiates osteoblast differentiation through upregulation of JunB in C2C12 cells. J. Cell Physiol., 207: 428-436.
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69:   Paul, W.E., R.A. Seder, J. Hu-Li, T. Tanaka and S.Z. Ben-Sasson, 1992. IL-4 is a major determinant of T cell lymphokine-producing phenotypes. Proceedings of the 8th International Congress of Immunology, August 23-28, 1992, Budapest, Hungary, pp: 347-354.
70:   Saiki, O., H. Ogawa, T. Ikeda, T. Masuno and T. Tanaka et al., 1992. Acquired T cell specific deficiency other than acquired immunodeficiency syndrome (AIDS). Intern. Med., 31: 11-16.
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71:   Saiki, O., H. Uda, M. Hayashi, T. Tanaka and Y. Katada et al., 1997. In vivo but not In vivo stimulations rescue of the defective class switching to IgG or IgA in B-cells of immunodeficiency with hyper IgM. Clin. Immunol. Immunopathol., 83: 287-292.
PubMed  |  Direct Link  |  
72:   Saiki, O., T. Tanaka and S. Kishimoto, 1990. Defective expression of p70/75 interleukin 2 receptor in T cells from patients with systemic lupus erythematosus: A possible defect in the process of increased intracellular calcium leading to p70/75 expression. J. Rheumatol., 17: 1303-1307.
PubMed  |  
73:   Saiki, O., T. Tanaka, S. Doi and S. Kishimoto, 1988. Expression and the functional role of a p70/75 interleukin 2-binding molecule in human B cell. J. Immunol., 140: 853-858.
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74:   Saiki, O., T. Tanaka, Y. Wada, H. Uda and A. Inoue et al., 1995. Signaling through CD40 rescues IgE but not IgG or IgA secretion in X-linked immunodeficiency with hyper-IgM. J. Clin. Invest., 95: 510-514.
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75:   Saiki, O., Y. Saeki, T. Tanaka, H. Hara, S. Negoro, T. Igarashi and S. Kishimoto, 1987. Development of selective IgM deficiency in systemic lupus erythematosus patients with disease of long duration. Arthritis Rheumatism, 30: 1289-1292.
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76:   Sasai, M., Y. Saeki, S. Ohshima, K. Nishioka and T. Mima et al., 1999. Delayed onset and reduced severity of collagen-induced arthritis in interleukin-6-deficient mice. Arthritis Rheum., 42: 1635-1643.
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77:   Serada, S., M. Fujimoto, T. Takahashi, P. He and A. Hayashi et al., 2007. Proteomic analysis of autoantigens associated with systemic lupus erythematosus: Anti-aldolase a antibody as a potential marker of lupus nephritis. Proteomics-Clin. Appl., 1: 185-191.
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78:   Shima, Y., M. Iwano, K. Yoshizaki, T. Tanaka, I. Kawase and N. Nishimoto, 2005. All-trans-retinoic acid inhibits the development of mesangial proliferative glomerulonephritis in interleukin-6 transgenic mice. Nephron. Exp. Nephrol., 100: 54-62.
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79:   Shima, Y., N. Hosen, T. Hirano, J. Arimitsu and S. Nishida, 2013. Expansion of range of joint motion following treatment of systemic sclerosis with tocilizumab. Modren Rheumatol., (In Press). 10.1007/s10165-013-0855-6.
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80:   Shima, Y., T. Tomita, T. Ishii, A. Morishima and Y. Maeda et al., 2011. Tocilizumab, a humanized Anti-interleukin-6 receptor antibody, ameliorated clinical symptoms and MRI findings of a patient with ankylosing spondylitis. Modern Rheumatol., 21: 436-439.
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81:   Shima, Y., Y. Kuwahara, H. Murota, S. Kitaba and M. Kawai et al, 2010. The skin of patients with systemic sclerosis softened during the treatment with anti-IL-6 receptor antibody tocilizumab. Rheumatology, 49: 2408-2412.
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82:   Suido, H., T. Tanaka, T. Tabei, A. Takeuchi and M. Okita et al., 2002. A mixed green vegetable and fruit beverage decreased the serum level of low-density lipoprotein cholesterol in hypercholesterolemic patients. J. Agric. Food Chem., 50 : 3346-3350.
PubMed  |  Direct Link  |  
83:   Tada, A., N. Hashida, T. Tanaka and K. Nishida, 2012. Anti-interleukin-6 receptor antibody therapy-induced retinopathy in a patient with rheumatoid arthritis. Case Report Rheumatol., Vol. 2012. 10.1155/2012/270315.
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84:   Tanaka, T. and R. Takahashi, 2013. Flavonoids and asthma. Nutrients, 5: 2128-2143.
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85:   Tanaka, T. and T. Kishimoto, 2012. Immunotherapeutic implication of IL-6 blockade. Immunotherapy, 4: 87-105.
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86:   Tanaka, T. and T. Kishimoto, 2012. Immunotherapy of tocilizumab for rheumatoid arthritis. J. Clin. Cell Immunol., S6: 1-8.
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87:   Tanaka, T. and T. Kishimoto, 2012. Targeting interleukin-6: All the way to treat autoimmune and inflammatory diseases. Int. J. Biol. Sci., 8: 1227-1236.
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88:   Tanaka, T., 2011. The effect of flavonoids on allergic diseases. Anti-Inflammatory Anti-Allergy Agents Med. Chem., 10: 374-381.
89:   Tanaka, T., 2012. Efficacy of Flavonoids for Patients with Japanese Cedar Pollinosis. In: Current Insights in Pollen Allergens, Jimenez-Lopez, J.C. (Ed.). Chapter 6, INTECH Open Access Publisher, Croatia, pp: 103-122.
90:   Tanaka, T., 2013. Can IL-6 blockade rectify imbalance between Tregs and Th17 cells? Immunotherapy, 5: 695-697.
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91:   Tanaka, T., 2013. Flavonoids as complementary medicine for allergic diseases: current evidence and future prospects. OA Alternative Med., Vol. 1. .
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92:   Tanaka, T., 2013. Flavonoids for allergic diseases: Present evidence and future perspective. Curr. Pharm. Des., (In Press). .
PubMed  |  Direct Link  |  
93:   Tanaka, T., A. Ogata and M. Narazaki, 2010. Tocilizumab for the treatment of rheumatoid arthritis. Expert Rev. Clin. Immunol., 6: 843-854.
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94:   Tanaka, T., A. Ogata and M. Narazaki, 2013. Tocilizumab: An updated review of its use in the treatment of rheumatoid arthritis and its application for other immune-mediated diseases. Clin. Med. Insights Therapeutics, 5: 33-52.
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95:   Tanaka, T., A. Ogata and T. Kishimoto, 2013. Targeting of interleukin-6 for the treatment of rheumatoid arthritis: A review and update. Rheumatol. Curr. Res., Vol. S4. 10.4172/2161-1149.S4-002.
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96:   Tanaka, T., A. Ogata, Y. Shima, M. Narazaki, A. Kumanogoh and T. Kishimoto, 2012. Therapeutic implications of tocilizumab, a humanized anti-interleukin-6 receptor antibody, for various immune-mediated diseases: An update review. Curr. Rheumatol. Rev., 8: 209-226.
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97:   Tanaka, T., A. Ogata, Y. Shima, M. Narazaki, A. Kumanogoh and T. Kishimoto, 2013. IL-6 Targeting Strategy for Various Immune-Mediated Diseases other than Rheumatoid Arthritis: An Update Review. In: Interleukin-6: Genetics, Clinical Applications and Role in Disease, D'Aquino, J. and E.N. DeVito (Eds.). Chapter 2, Nova Science Publishers, USA., pp: 61-110.
98:   Tanaka, T., C.C. Chu and W.E. Paul, 1992. An antisense oligonucleotide complementary to a sequence in I gamma 2b increases gamma 2b germline transcripts, stimulates B cell DNA synthesis and inhibits immunoglobulin secretion. J. Exp. Med., 175: 597-607.
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99:   Tanaka, T., H. Tsutsui, T. Yoshimoto, M. Kotani and M. Matsumoto et al., 2001. Interleukin-18 is elevated in the sera from patients with atopic dermatitis and from atopic dermatitis model mice, NC/Nga. Int. Arch. Allergy Immunol., 125: 236-240.
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100:   Tanaka, T., I. Kawase and T. Kishimoto, 2010. Reply to interleukin-6 as a target in spondyloarthritis. Arthrit. Care Res., 62: 745-746.
101:   Tanaka, T., J. Hu-Li, R.A. Seder, B.F. de St Groth and W.E. Paul, 1993. Interleukin 4 suppresses interleukin 2 and interferon gamma production by naive T cells stimulated by accessory cell-dependent receptor engagement. Proc. Natil. Acad. Sci., 90: 5914-5918.
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102:   Tanaka, T., K. Hagihara, Y. Shima, M. Narazaki, A. Ogata and A. Kumanogoh, 2011. Tocilizumab, a humanized Anti-interleukin-6 receptor antibody, for the treatment of autoimmune disorders. Drug Dev. Res., 72: 717-732.
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103:   Tanaka, T., K. Hagihara, Y. Shima, M. Narazaki, A. Ogata, I. Kawase and T. Kishimoto, 2010. Treatment of a patient with remitting seronegative, symmetrical synovitis with pitting oedema with a humanized anti-interleukin-6 receptor antibody, tocilizumab. Rheumatology, 49: 824-826.
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104:   Tanaka, T., K. Kouda, M. Kotani, A. Takeuchi and T. Tabei et al., 2001. Vegetarian diet ameliorates symptoms of atopic dermatitis through reduction of the number of peripheral eosinophils and of PGE2 synthesis by monocytes. J. Phsiol. Anthropol. Appl. Human Sci., 20: 353-361.
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105:   Tanaka, T., M. Narazaki and T. Kishimoto, 2011. Anti-interleukin-6 receptor antibody, tocilizumab, for the treatment of autoimmune diseases. FEBS Lett., 585: 3699-3709.
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106:   Tanaka, T., M. Narazaki and T. Kishimoto, 2012. Therapeutic targeting of the interleukin-6 receptor. Ann. Rev. Pharmacol. Toxicol., 52: 199-219.
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107:   Tanaka, T., M. Narazaki and T. Kishimoto, 2014. Interleukin-6. In: Encyclopedia of Medical Immunology, Mackay, I.R. and N.R. Rose (Eds.). Chapter 36, Springer, New York.
108:   Tanaka, T., M. Narazaki, K. Masuda and T. Kishimoto, 2013. Interleukin-6: Pathogenesis and treatment of autoimmune inflammatory diseases. Inflammat. Regenerat., 33: 54-65.
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109:   Tanaka, T., O. Saiki, M. Hatakeyama, T. Kono and H. Mori et al., 1987. Functional interleukin 2 receptors on B cells lacking Tac antigens. Eur. J. Immunol., 17: 1379-1382.
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110:   Tanaka, T., O. Saiki, S. Doi, M. Fujii and K. Sugamura et al., 1988. Novel receptor-mediated internalization of interleukin 2 in B cells. J. Immunol., 140: 866-870.
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111:   Tanaka, T., O. Saiki, S. Doi, M. Suemura, S. Negoro and S. Kishimoto, 1988. Expression of novel interleukin 2 binding molecules and their functional roles in human B cell differentiation. J. Clin. Invest., 82: 316-321.
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112:   Tanaka, T., O. Saiki, S. Doi, S. Negoro and S. Kishimoto, 1988. Interleukin 2 functions through novel interleukin 2 binding molecules in T cells. J. Immunol., 140: 470-473.
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113:   Tanaka, T., O. Saiki, S. Negoro, T. Igarashi and T. Kuritani et al., 1989. Decreased expression of interleukin-2 binding molecules (p70/75) in T cells from patients with systemic lupus erythematosus. Arthritis Rheumatism, 32: 552-559.
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114:   Tanaka, T., S. Higa, T. Hirano, J. Arimitsu and T. Naka et al., 2004. Is an appropriate intake of flavonoids a prophylactic means or complementary and alternative medicine for allergic diseases? Recent. Res. Devel. Allergy Clin. Immunol., 5: 1-14.
115:   Tanaka, T., S. Higa, T. Hirano, M. Kotani, M. Matsumoto, A. Fujita and I. Kawase, 2003. Flavonoids as potential anti-allergic substances. Curr. Med. Chem. Anti-Inflamm. Anti-Allergy Agents, 2: 57-65.
116:   Tanaka, T., S. Kishimoto and O. Saiki, 1989. Different induction of p55 and p70/75 interleukin-2 receptor subunits in human cells. Biochem. Biophys Res. Commun., 164: 686-692.
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117:   Tanaka, T., S.Z. Ben-Sasson and W.E. Paul, 1991. IL-4 increases IL-2 production by T cells in response to accessory cell-independent stimuli. J. Immunol., 146: 3831-3839.
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118:   Tanaka, T., T. Hirano, M. Kawai, J. Arimitsu and K. Hagihara et al., 2011Tanaka, T., T. Hirano, M. Kawai, J. Arimitsu and K. Hagihara et al., 2011. Flavonoids, Natural Inhibitors of Basophil Activation. In: Cell Biology Research Progress, Vellis, P.K. (Ed.). Nova Science Publishers, New York, pp: 61-72.
119:   Tanaka, T., Y. Katada, H. Ochi, M. Suemura and T. Kishimoto, 1996. IL-2, IL-4, IL-6, IL-10, IFN-gamma, their Receptors, Modulation of their Actions and Role in Allergic Responses. In: Immunopharmacology of Allergic Diseases, Townley R.G. and Argawal D.K. Marcel (Eds.). Dekker, Inc., Switzerland, pp: 365-381.
120:   Tanaka, T., Y. Katada, M. Suemura and T. Kishimoto, 1993. Interleukin-6. In: Cytokine Regulation of Humoral Immunity: Basic and Clinical Aspects, Snapper C.M. (Ed.). John Wiley and Sons, Ltd., England, pp: 251-272.
121:   Tanaka, T., Y. Katada, S. Higa, H. Fujiwara and W. Wang et al., 2001. Enhancement of T helper 2 response in the absence of interleukin (IL-)6; An inhibition of IL-4-mediated T helper 2 cell differentiation by IL-6. Cytokine, 13: 193-201.
122:   Tanaka, T., Y. Kuwahara, Y. Shima, T. Hirano and M. Kawai et al., 2009. Successful treatment of reactive arthritis with a humanized anti-interleukin-6 receptor antibody, tocilizumab. Arthrit. Care Res., 61: 1762-1764.
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123:   Terabe, F., M. Kitano, M. Kawai, Y. Kuwahara and T. Hirano et al., 2009. Imatinib mesylate inhibited rat adjuvant arthritis and PDGF-dependent growth of synovial fibroblast via interference with the Akt signaling pathway. Modern Rheumatol., 19: 522-529.
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124:   Wang, W., T. Tanaka, H. Okamura, M. Sugita, S. Higa, T. Kishimoto and M. Suemura, 2001. Interleukin-18 enhances the production of interleukin-8 by eosinophils. Eur. J. Immunol., 31 : 1010-1016.
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125:   Watanabe, D., S. Ezoe, M. Fujimoto, A. Kimura and Y. Saito et al., 2004. Suppressor of cytokine signalling-1 gene silencing in acute myeloid leukaemia and human haematopoietic cell lines. Br. J. Haematol., 126: 726-735.
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126:   Yamaguchi, T., S. Ohshima, T. Tanaka, S. Tsukada and M. Matsushita et al., 2001. Renal crisis due to intimal hyperplasia in a patient with mixed connective tissue disease (MCTD) accompanied by pulmonary hypertension. Intern. Med., 40: 1250-1253.
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127:   Yokota, A., M. Narazaki, Y. Shima, N. Murata and T. Tanaka et al., 2001. Preferential and persistent activation of the STAT1 pathway in rheumatoid synovial fluid cells. J. Rheumatol., 28: 1952-1959.
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128:   Yokota, S., T. Tanaka and T. Kishimoto, 2012. Efficacy, safety and tolerability of tocilizumab in patients with systemic juvenile idiopathic arthritis. Ther. Adv. Musculoskelet. Dis., 4: 387-397.
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129:   Yoshimoto, T., Nakanishi, K. Matsui, K. Hirose and S. Hiroishi et al., 1990. IL-5 up-regulates but IL-4 down-regulates IL-2R expression on a cloned B lymphoma line. J. Immunol., 144: 183-190.
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