Dr. Michael Lee
My Social Links

Dr. Michael Lee

Professor
Incheon National University, South Korea

Highest Degree
Ph.D. in Biological Sciences from KAIST University, South Korea

Share this Profile

Area of Interest:

Biomedical Sciences
100%
Immunology
62%
Comparative Anatomy
90%
Life Sciences
75%
Human Anatomy
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Ahn, J.H., S.H. Hwang, H.S. Cho and M. Lee, 2019. Differential gene expression common to acquired and intrinsic resistance to BRAF inhibitor revealed by RNA-Seq analysis. Biomol. Ther., (In Press). 10.4062/biomolther.2018.133.
    CrossRef  |  Direct Link  |  
  2. Hwang, S. H., B.I. Han and M. Lee, 2018. Knockout of ATG5 leads to malignant cell transformation and resistance to Src family kinase inhibitor PP2. J. Cell. Physiol., 233: 506-515.
    CrossRef  |  
  3. Kim, J.H, J.H. Ahn and M. Lee, 2017. Upregulation of microRNA-1246 is associated with BRAF inhibitor resistance in melanoma cells with mutant BRAF. Cancer Res. Treat., 49: 947-959.
    CrossRef  |  
  4. Han, B.I., S.H. Hwang and M. Lee, 2017. A progressive reduction in autophagic capacity contributes to induction of replicative senescence in Hs68 cells. Int. J. Biochem. Cell Biol., 92: 18-25.
    CrossRef  |  
  5. Klionsky, D.J., K. Abdelmohsen, A. Abe, M.J. Abedin and H. Abeliovich et al., 2016. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12: 1-222.
    CrossRef  |  Direct Link  |  
  6. Kim, N.Y., B.I. Han and M. Lee, 2016. Cytoprotective role of autophagy against BH3 mimetic gossypol in ATG5 knockout cells generated by CRISPR-Cas9 endonuclease. Cancer Lett., 370: 19-26.
    CrossRef  |  Direct Link  |  
  7. Jang, G.H., J. Lee, N.Y. Kim, J.H. Kim and J.Y. Yeh et al., 2016. Suppression of lytic replication of Kaposi’s sarcoma-associated herpesvirus by autophagy during initial infection in NIH 3T3 fibroblasts. Arch. Virol., 161: 595-604.
    CrossRef  |  Direct Link  |  
  8. Han, B.I. and M. Lee, 2016. Paclitaxel-induced G2/M arrest via different mechanism of actions in glioma cell lines with differing p53 mutational status. Int. J. Pharmacol., 12: 19-27.
    CrossRef  |  Direct Link  |  
  9. Jang, G.H., N.Y. Kim and M. Lee, 2015. Low inducible expression of p21Cip1 confers resistance to paclitaxel in BRAF mutant melanoma cells with acquired resistance to BRAF inhibitor. Mol. Cell. Biochem., 406: 53-62.
    CrossRef  |  
  10. Ahn, J.H., B.I. Han and M. Lee, 2015. Induction of resistance to BRAF inhibitor is associated with the inability of Spry2 to inhibit BRAF-V600E activity in BRAF mutant cells. Biomol. Ther., 23: 320-326.
    CrossRef  |  PubMed  |  Direct Link  |  
  11. Kim, N.Y. and M. Lee, 2014. The pro-death role of autophagy and apoptosis in cell death induced by the BH3 mimetic gossypol. Anim. Cells Syst., 18: 183-189.
    CrossRef  |  Direct Link  |  
  12. Kim, N.Y. and M. Lee, 2014. Autophagy-mediated growth inhibition of malignant glioma cells by the BH3-mimetic gossypol. Mol. Cell. Toxicol., 10: 157-164.
    CrossRef  |  Direct Link  |  
  13. Jang, G.H. and M. Lee, 2014. BH3-mimetic gossypol-induced autophagic cell death in mutant BRAF melanoma cells with high expression of p21Cip1. Life Sci., 102: 41-48.
    CrossRef  |  Direct Link  |  
  14. Ahn, J.H., Y.W. Lee, S.K. Ahn and M. Lee, 2014. Oncogenic BRAF inhibitor UAI-201 induces cell cycle arrest and autophagy in BRAF mutant glioma cells. Life Sci., 104: 38-46.
    CrossRef  |  Direct Link  |  
  15. Ahn, J.H. and M. Lee, 2014. The siRNA-mediated downregulation of N-Ras sensitizes human melanoma cells to apoptosis induced by selective BRAF inhibitors. Mol. Cell. Biochem., 392: 239-247.
    CrossRef  |  
  16. Eum, K.H., S.K. Ahn, H. Kang and M. Lee, 2013. Differential inhibitory effects of two Raf-targeting drugs, sorafenib and PLX4720, on the growth of multidrug-resistant cells. Mol. Cell. Biochem., 372: 65-74.
    CrossRef  |  Direct Link  |  
  17. Ahn, J.H. and M. Lee, 2013. Autophagy-dependent survival of mutant B-Raf melanoma cells selected for resistance to apoptosis induced by inhibitors against oncogenic B-Raf. Biomol. Ther., 21: 114-120.
    CrossRef  |  Direct Link  |  
  18. Ahn, J H., G.H. Jang and M. Lee, 2013. Defective autophagy in multidrug resistant cells may lead to growth inhibition by BH3‐mimetic gossypol. J. Cell. Physiol., 228: 1496-1505.
    CrossRef  |  Direct Link  |  
  19. Klionsky, D.J., F.C. Abdalla, H. Abeliovich, R.T. Abraham and A. Acevedo-Arozena et al., 2012. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8: 445-544.
    PubMed  |  Direct Link  |  
  20. Kim, Y.K., S.K. Ahn and M. Lee, 2012. Differential sensitivity of melanoma cell lines with differing B-Raf mutational status to the new oncogenic B-Raf kinase inhibitor UI-152. Cancer Lett., 320: 215-224.
    CrossRef  |  Direct Link  |  
  21. Kim, Y.K., J.H. Ahn and M. Lee, 2012. Src family kinase inhibitor PP2 induces LC3 conversion in a manner that is uncoupled from autophagy and increases apoptosis in multidrug-resistant cells. Biomol. Ther., 20: 393-398.
    CrossRef  |  PubMed  |  Direct Link  |  
  22. Ahn, J.H., S.K. Ahn and M. Lee, 2012. The role of autophagy in cytotoxicity induced by new oncogenic B-Raf inhibitor UI-152 in v-Ha-ras transformed fibroblasts. Biochem. Biophys. Res. Commun., 417: 857-863.
    CrossRef  |  Direct Link  |  
  23. Eum, K.H. and M. Lee, 2011. Crosstalk between autophagy and apoptosis in the regulation of paclitaxel-induced cell death in v-Ha-ras-transformed fibroblasts. Mol. Cell. Biochem., 348: 61-68.
    CrossRef  |  Direct Link  |  
  24. Ahn, J.H., Y.K. Kim and M. Lee, 2011. Decreased interaction of Raf-1 with its negative regulator Spry2 as a mechanism for acquired drug resistance. Biomol. Ther., 19: 174-180.
    CrossRef  |  Direct Link  |  
  25. Ahn, J.H. and M. Lee, 2011. Suppression of autophagy sensitizes multidrug resistant cells towards Src tyrosine kinase specific inhibitor PP2. Cancer Lett., 310: 188-197.
    CrossRef  |  Direct Link  |  
  26. Kwon, S.C., G.S. Lee, J.Y. Han, M. Lee, Y.M. Lee, W.S. Koh and J.Y. Kim, 2010. Genotoxicity studies on HM10760A, recombinant human erythropoietin conjugated to globin fragment. Drug Chem. Toxicol., 33: 152-159.
    CrossRef  |  Direct Link  |  
  27. Eum, K.H. and M. Lee, 2010. Targeting the autophagy pathway using ectopic expression of Beclin 1 in combination with rapamycin in drug-resistant v-Ha-ras-transformed NIH 3T3 cells. Mol. Cells, 31: 231-238.
    CrossRef  |  Direct Link  |  
  28. Ahn, J.H., K.H. Eum, S.W. Oh, Y.J. Kim and M. Lee, 2010. Assessment of the dermal and ocular irritation potential of alcohol hand sanitizers containing aloe vera with in vitro and in vivo methods. Mol. Cell. Toxicol., 6: 401-408.
    CrossRef  |  Direct Link  |  
  29. Ahn, J.H., K.H. Eum and M. Lee, 2010. Spry2 does not directly modulate Raf-1 kinase activity in v-Ha-ras-transformed NIH 3T3 fibroblasts. BMB Rep., 43: 205-211.
    CrossRef  |  Direct Link  |  
  30. Lee, M., J.H. Ahn and K.H. Eum, 2009. The difference in biological properties between parental and v-Ha-ras transformed NIH3T3 cells. Cancer Res. Treat., 41: 93-99.
    CrossRef  |  PubMed  |  Direct Link  |  
  31. Jeong, Y.K., J.S. Kang, J.H. Kim, S.K. Suh and M. Lee et al., 2009. Differences in gene expression profiles reflecting differences in drug sensitivity to acetaminophen in normal and transformed hepatic cell lines in vitro. Mol. Cell. Toxicol., 5: 32-43.
  32. Chung, Y.S., K.H. Eum, J.H. Ahn, S.A. Choi and H.J. Noh et al., 2009. Genotoxicity assessment of gardenia yellow using short-term assays. Mol. Cell. Toxicol., 5: 257-264.
    Direct Link  |  
  33. Ahn, J.H., K.H. Eum and M. Lee, 2009. The enhancement of Raf-1 kinase activity by knockdown of Spry2 is associated with high sensitivity to paclitaxel in v-Ha-ras-transformed NIH 3T3 fibroblasts. Mol. Cell. Biochem., 332: 189-197.
    CrossRef  |  Direct Link  |  
  34. Lee, Y.M., W.H. Choi, Y.B. Kim, C.S. Ha and C.W. Song et al., 2008. Toxicity of repeated intravenous injection of gene therapeutics for X-CGD in mice. Hum. Exp. Toxicol., 27: 401-407.
    CrossRef  |  Direct Link  |  
  35. Lee, M., 2008. Overexpression of human Raf‐1 enhances radiosensitivity in fission yeast, Schizosaccharomyces pombe. Cell Biochem. Funct., 26: 125-131.
    CrossRef  |  Direct Link  |  
  36. Kim, J.Y., S.Y. Hong, Y.M. Lee, S.A. Yu and W.S. Koh et ala., 2008. In vitro assessment of clastogenicity of mobile‐phone radiation (835 MHz) using the alkaline comet assay and chromosomal aberration test. Environ. Toxicol.: Int. J., 23: 319-327.
    CrossRef  |  Direct Link  |  
  37. Ahn, J.H. and M. Lee, 2008. Tyrosine phosphorylation and Ras activation is required for hydrogen peroxide-mediated Raf-1 kinase activation. Mol. Cell. Biochem., 317: 121-129.
    CrossRef  |  Direct Link  |  
  38. Lee, M. and H.S. Yoo, 2007. Human Raf‐1 proteins associate with Rad24 and Cdc25 in cell‐cycle checkpoint pathway of fission yeast, Schizosaccharomyces pombe. J. Cell. Biochem., 101: 488-497.
    CrossRef  |  Direct Link  |  
  39. Kim, J.Y., Y.M. Lee, W.S. Koh, C.Y. Kim and I.Y. Choi et al., 2007. Genotoxicity assessment of HM10620 containing recombinant human interferon-α. Drug Chem. Toxicol., 30: 83-95.
    CrossRef  |  Direct Link  |  
  40. Lee, M., 2006. Raf-1 kinase activation is uncoupled from downstream MEK/ERK pathway in cells treated with Src tyrosine kinase inhibitor PP2. Biochem. Biophys. Res. Commun., 350: 450-456.
    CrossRef  |  Direct Link  |  
  41. Kim, J.Y., J. Kwon, J.E. Kim, W.S. Koh and M.K. Chung et al., 2005. Identification of potential biomarkers of genotoxicity and carcinogenicity in L5178Y mouse lymphoma cells by cDNA microarray analysis. Environ. Mol. Mutagen., 45: 80-89.
    CrossRef  |  Direct Link  |  
  42. Chang, S.K., J.S. Choi, H.W. Gil, J.O. Yang and E.Y. Lee et al., 2005. Genotoxicity evaluation of electromagnetic fields generated by 835-MHz mobile phone frequency band. Eur. J. Cancer Prev., 14: 175-179.
    Direct Link  |  
  43. Lee, M., J.Y. Kim and W.S. Koh, 2004. Apoptotic effect of PP2 a Src tyrosine kinase inhibitor, in murine B cell leukemia. J. Cell. Biochem., 93: 629-638.
    CrossRef  |  Direct Link  |  
  44. Lee, M., J.Y. Kim and W.B. Anderson, 2004. Src tyrosine kinase inhibitor PP2 markedly enhances Ras-independent activation of Raf-1 protein kinase by phorbol myristate acetate and H2O2. J. Biol. Chem., 279: 48692-48701.
    CrossRef  |  Direct Link  |  
  45. Lee, M., W.S. Koh and S.S. Han, 2003. Down-regulation of Raf-1 kinase is associated with paclitaxel resistance in human breast cancer MCF-7/Adr cells. Cancer Lett., 193: 57-64.
    CrossRef  |  Direct Link  |  
  46. Lee, M., J. Kwon, S.N. Kim, J.E. Kim and W.S. Koh et al., 2003. cDNA microarray gene expression profiling of hydroxyurea, paclitaxel and p‐anisidine, genotoxic compounds with differing tumorigenicity results. Environ. Mol. Mutagen., 42: 91-97.
    CrossRef  |  Direct Link  |  
  47. Lee, M., J. Kwon and M.K. Chung, 2003. Enhanced prediction of potential rodent carcinogenicity by utilizing comet assay and apoptotic assay in combination. Mutat. Res./Genet. Toxicol. Environ. Mutagen., 541: 9-19.
    CrossRef  |  Direct Link  |  
  48. Lee, M., G. Petrovics and W.B. Anderson, 2003. The synergistic activation of Raf-1 kinase by phorbol myristate acetate and hydrogen peroxide in NIH3T3 cells. Biochem. Biophys. Res. Commun., 311: 1026-1033.
    CrossRef  |  Direct Link  |  
  49. Lee, M. and W.S. Koh, 2003. Raf‐independent and MEKK1‐dependent activation of NF‐κB by hydrogen peroxide in 70Z/3 pre‐B lymphocyte tumor cells. J. Cell. Biochem., 88: 545-556.
    CrossRef  |  Direct Link  |  
  50. Lee, J.W., K.D. Shin, M. Lee, E.J. Kim and S.S. Han et al., 2003. Role of metabolism by flavin-containing monooxygenase in thioacetamide-induced immunosuppression. Toxicol. Lett., 136: 163-172.
    CrossRef  |  Direct Link  |  
  51. Lee, M. and S.S. Han, 2002. Choline phosphate potentiates sphingosine-1-phosphate-induced Raf-1 kinase activation dependent of Ras-phosphatidylinositol-3-kinase pathway. Cell. Signal., 14: 373-379.
    CrossRef  |  Direct Link  |  
  52. Lee, M. and Y.J. Jeon, 2001. Paclitaxel-induced immune suppression is associated with NF-κB activation via conventional PKC isotypes in lipopolysaccharide-stimulated 70Z/3 pre-B lymphocyte tumor cells. Mol. Pharmacol., 59: 248-253.
    CrossRef  |  Direct Link  |  
  53. Hong, J.H., S.O. Oh, M. Lee, Y.R. Kim and D.U. Kim et al., 2001. Enhancement of lysophosphatidic acid-induced ERK phosphorylation by phospholipase D1 via the formation of phosphatidic acid. Biochem. Biophys. Res. Commun., 281: 1337-1342.
    CrossRef  |  Direct Link  |  
  54. Lee, Y.W., S.H. Han, M. Lee, K.H. Yang, H.M. Kim and Y.J. Jeon, 2000. 2-Amino-3-methylimidazo [4,5-f] quinoline inhibits nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells by blocking p38 kinase activation. Cancer Lett., 156: 133-139.
    CrossRef  |  Direct Link  |  
  55. Lee, M., S.S. Yea and Y.J. Jeon, 2000. Paclitaxel causes mouse splenic lymphocytes to a state hyporesponsive to lipopolysaccharide stimulation. Int. J. Immunopharmacol., 22: 615-621.
    CrossRef  |  Direct Link  |  
  56. Lee, M. and S.S. Yea, 2000. Hydrogen peroxide inhibits the immune response to lipopolysaccharide by attenuating signaling through c-Jun N-terminal kinase and p38 associated with protein kinase C. Immunopharmacology, 48: 165-172.
    CrossRef  |  Direct Link  |  
  57. Lee, M. and K.H. Yang, 2000. 2-Acetylaminofluorene suppresses immune response through the inhibition of nuclear factor-κB activation during the early stage of B cell development. Toxicol. Lett., 114: 173-180.
    CrossRef  |  Direct Link  |  
  58. Jeon, Y.J., Y.K. Kim, M. Lee, S.M. Park, S.B. Han and H.M. Kim, 2000. Radicicol suppresses expression of inducible nitric-oxide synthase by blocking p38 kinase and nuclear factor-κB/Rel in lipopolysaccharide-stimulated macrophages. J. Pharmacol. Exp. Ther., 294: 548-554.
    Direct Link  |  
  59. Jeon, Y.J., S.H. Han, Y.W. Lee, M. Lee, K.H. Yang and H.M. Kim, 2000. Dexamethasone inhibits IL-1β gene expression in LPS-stimulated RAW 264.7 cells by blocking NF-κB/Rel and AP-1 activation. Immunopharmacology, 48: 173-183.
    CrossRef  |  Direct Link  |  
  60. Schatz, A.R., M. Lee, R.B. Condie, J.T. Pulaski and N.E. Kaminski, 1997. Cannabinoid receptors CB1 and CB2: A characterization of expression and adenylate cyclase modulation within the immune system. Toxicol. Applied Pharmacol., 142: 278-287.
    CrossRef  |  Direct Link  |  
  61. Ferrier, A.F., M. Lee, W.B. Anderson, G. Benvenuto, D.K. Morrison, D.R. Lowy and J.E. DeClue, 1997. Sequential modification of serines 621 and 624 in the Raf-1 carboxyl terminus produces alterations in its electrophoretic mobility. J. Biol. Chem., 272: 2136-2142.
    CrossRef  |  Direct Link  |  
  62. Lee, M., H.M. Kim and K.H. Yang, 1996. Down-regulation of protein kinase C in murine splenocytes: a potential mechanism for 2-acetylaminofluorene-mediated immunosuppression. Cancer Lett., 101: 53-57.
    CrossRef  |  Direct Link  |  
  63. Koh, W.S., M. Lee, K.H. Yang and N.E. Kaminski, 1996. Expression of functional glucagon receptors on lymphoid cells. Life Sci., 58: 741-751.
    CrossRef  |  Direct Link  |  
  64. Condie, R., A.C. Herring, W.S. Koh, M. Lee and N.E. Kaminski, 1996. Cannabinoid inhibition of adenylate cyclase-mediated signal transduction and IL-2 expression in the murine T-cell line, EL4.IL-2. J. Biol. Chem., 271: 13175-13183.
    CrossRef  |  Direct Link  |  
  65. Lee, M., K.H. Yang and N.E. Kaminski, 1995. Effects of putative cannabinoid receptor ligands, anandamide and 2-arachidonyl-glycerol, on immune function in B6C3F1 mouse splenocytes. J. Pharmacol. Exp. Ther., 275: 529-536.
    Direct Link  |  
  66. Kaminski, N.E., W.S. Koh, K.H. Yang, M. Lee and F.K. Kessler, 1994. Suppression of the humoral immune response by cannabinoids is partially mediated through inhibition of adenylate cyclase by a pertussis toxin-sensitive G-protein coupled mechanism. Biochem. Pharm., 48: 1899-1908.
    CrossRef  |  Direct Link  |