Hi, I am Yu Wang, My LiveDNA is 852.6351
 
   
  Home
 
 
 
Dr. Yu Wang
 
Highest Degree: Ph.D. in Biomedical Sciences from University of Auckland, New Zealand
 
Institute: The University of Hong Kong, Hong Kong
 
Area of Interest: Molecular Sciences
  •   Obesity and Metabolism
  •   Carcinogenesis
  •   Ageing
  •   Applied Pharmacology
 
URL: http://livedna.org/852.6351
 
My SELECTED Publications
1:   Bai, B. and Y. Wang, 2011. The use of lorcaserin in the management of obesity: A critical appraisal. Drug Design. Dev. Therapy, 5: 1-7.
CrossRef  |  
2:   Bai, B. and Y. Wang, 2013. Methods to investigate the role of SIRT1 in endothelial senescence. Methods Mol. Biol., 965: 327-339.
CrossRef  |  PubMed  |  Direct Link  |  
3:   Bai, B., Y. Liang, C. Xu, M.Y. Lee and A. Xu et al., 2012. CDK5-mediated hyperphosphorylation of SIRT1 contributes to the development of endothelial senescence and atherosclerosis. Circulation, 126: 729-740.
4:   Chang, J., Y. Li, Y. Huang, K.S. Lam and R.L. Hoo et al., 2010. Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signaling pathway. Diabetes, 59: 2949-2959.
CrossRef  |  PubMed  |  Direct Link  |  
5:   Chen, B., K.S. Lam, Y. Wang, D. Wu and M.C. Lam et al., 2006. Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes. Biochem. Biophys. Res. Commun., 341: 549-556.
CrossRef  |  PubMed  |  Direct Link  |  
6:   Chen, C., B.M. Cheung, A.W. Tso, Y. Wang and L.S. Law et al., 2011. High plasma level of FGF21 is an independent predictor of type 2 diabetes: A 5.4-year population-based prospective study in Chinese subjects. Diabetes Care, 34: 2113-2115.
7:   Cheng, K.K., K.S. Lam, D. Wu, Y. Wang and G. Sweeney et al., 2012. APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice. Proc. Natl. Acad. Sci., 109: 8919-8924.
CrossRef  |  PubMed  |  
8:   Cheng, K.K., K.S. Lam, Y. Wang, D. Wu and M. Zhang et al., 2013. TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt. Biochem. J., 455: 207-216.
CrossRef  |  PubMed  |  
9:   Cheng, K.K., K.S. Lam, Y. Wang, H. Yu and D. Carling et al., 2007. Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells. Diabetes, 56: 1387-1394.
PubMed  |  
10:   Cheng, K.K., M.A. Iglesias, K.S. Lam, Y. Wang and G. Sweeney et al., 2009. APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice. Cell Metab., 9: 417-427.
CrossRef  |  PubMed  |  Direct Link  |  
11:   Choi, K.L., Y. Wang, C. Tse, G.J. Cooper and A. Xu, 2004. Proteomic analysis of adipocyte differentiation: Evidence that α2 macroglobulin is involved in the adipose conversion of 3T3 L1 preadipocytes. Proteomics, 4: 1840-1848.
CrossRef  |  PubMed  |  Direct Link  |  
12:   Chow, K.H., J. Liu, R.W. Sun, P.M. Vanhoutte and A. Xu et al., 2011. The gold (III) porphyrin complex, gold-2a, suppresses WNT1 expression in breast cancer cells by enhancing the promoter association of YY1. Am. J. Transl. Res., 3: 479-491.
13:   Chow, K.H.M., R.W.Y. Sun, J.B.B. Lam, C.K.L. Li and A. Xu et al., 2010. A gold(iii) porphyrin complex with antitumor properties targets the Wnt/β-catenin pathway. Cancer Res., 70: 329-337.
CrossRef  |  
14:   Deng, M.Y., S. Lam, U. Meyer, J. Feldon and Q. Li et al., 2011. Frontal-Subcortical protein expression following prenatal exposure to maternal inflammation. PLoS One, Vol. 6. 10.1371/journal.pone.0016638.
CrossRef  |  
15:   Fang, X., R. Palanivel, X. Zhou, Y. Liu, A. Xu, Y. Wang and G. Sweeney, 2005. Hyperglycemia-and hyperinsulinemia-induced alteration of adiponectin receptor expression and adiponectin effects in L6 myoblasts. J. Mol. Endocrinol., 35: 465-476.
PubMed  |  
16:   Gao, M., D. Ding, J. Huang, Y. Qu, Y. Wang and Q. Huang, 2013. Association of genetic variants in the adiponectin gene with metabolic syndrome: A case-control study and a systematic meta-analysis in the Chinese population. PLoS One, Vol. 8. 10.1371/journal.pone.0058412.
CrossRef  |  PubMed  |  
17:   Gao, X., K. Li, X. Hui, X. Kong and G. Sweeney et al., 2011. Carnitine palmitoyltransferase 1A prevents fatty acid-induced adipocyte dysfunction through suppression of c-Jun N-Terminal kinase. Biochem. J., 435: 723-732.
CrossRef  |  PubMed  |  
18:   Ge, X., C. Chen, X. Hui, Y. Wang, K.S.L. Lam and A. Xu, 2011. Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes. J. Biol. Chem., 286: 34533-34541.
CrossRef  |  PubMed  |  
19:   Ge, X., Y. Wang, K.S. Lam and A. Xu, 2012. Metabolic actions of FGF21: Molecular mechanisms and therapeutic implications. Acta Pharmaceutica Sinica B, 2: 350-357.
CrossRef  |  Direct Link  |  
20:   Herath, T.D., R.P. Darveau, C.J. Seneviratne, C.Y. Wang, Y. Wang and L. Jin, 2013. Tetra-and penta-acylated lipid A structures of Porphyromonas gingivalis LPS differentially activate TLR4-mediated NF-κB signal transduction cascade and immuno-inflammatory response in human gingival fibroblasts. PLoS One, Vol. 8. 10.1371/journal.pone.0058496.
CrossRef  |  PubMed  |  
21:   Herath, T.D., Y. Wang, C.J. Seneviratne, Q. Lu, R.P. Darveau, C.Y. Wang and L. Jin, 2011. Porphyromonas gingivalis lipopolysaccharide lipid A heterogeneity differentially modulates the expression of IL-6 and IL-8 in human gingival fibroblasts. J. Clin. Periodontol., 38: 694-701.
CrossRef  |  PubMed  |  Direct Link  |  
22:   Herath, T.D., Y. Wang, C.J. Seneviratne, R.P. Darveau, C.Y. Wang and L. Jin, 2013. The expression and regulation of matrix metalloproteinase-3 is critically modulated by Porphyromonas gingivalis lipopolysaccharide with heterogeneous lipid A structures in human gingival fibroblasts. BMC Microbiol., Vol. 13. 10.1186/1471-2180-13-73.
CrossRef  |  Direct Link  |  
23:   Hui, X., H. Li, Z. Zhou, K.S. Lam and Xiao et al., 2010. Adipocyte fatty acid-binding protein modulates inflammatory responses in macrophages through a positive feedback loop involving c-Jun NH2-terminal kinases and activator protein-1. J. Biol. Chem., 285: 10273-10280.
CrossRef  |  PubMed  |  
24:   Hui, X., W. Zhu, Y. Wang, K.S. Lam and J. Zhang et al., 2009. Major urinary protein-1 increases energy expenditure and improves glucose intolerance through enhancing mitochondrial function in skeletal muscle of diabetic mice. J. Biol. Chem., 284: 14050-14057.
CrossRef  |  PubMed  |  
25:   Jang, Y.S., J.H. Lee, Y. Wang and G. Sweeney, 2012. Emerging clinical and experimental evidence for the role of lipocalin-2 in metabolic syndrome. Clin. Exp. Pharmacol. Physiol., 39: 194-199.
CrossRef  |  Direct Link  |  
26:   Jullig, M., X. Chen, A.J. Hickey, D.J. Crossman and A. Xu et al., 2007. Reversal of diabetes-evoked changes in mitochondrial protein expression of cardiac left ventricle by treatment with a copper(II)-selective chelator. Proteomics Clin. Appl., 1: 387-399.
CrossRef  |  PubMed  |  Direct Link  |  
27:   Lam, J.B., K.H. Chow, A. Xu, K.S. Lam and J. Liu et al., 2009. Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities. PLoS One, Vol. 4. 10.1371/journal.pone.0004968.
CrossRef  |  
28:   Law, I.K., A. Xu, K.S. Lam, T. Berger and T.W. Mak et al., 2010. Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity. Diabetes, 59: 872-882.
CrossRef  |  PubMed  |  
29:   Law, I.K., L. Liu, A. Xu, K.S. Lam and P.M. Vanhoutte et al., 2009. Identification and characterization of proteins interacting with SIRT1 and SIRT3: Implications in the anti-aging and metabolic effects of sirtuins. Proteomics, 9: 2444-2456.
CrossRef  |  PubMed  |  Direct Link  |  
30:   Lee, M.Y., Y. Wang and P.M. Vanhoutte, 2010. Senescence of cultured porcine coronary arterial endothelial cells is associated with accelerated oxidative stress and activation of NFΚB. J. Vasc. Res., 47: 287-298.
CrossRef  |  PubMed  |  
31:   Lee, M.Y.K., Y. Cai, Y. Wang, S.Y. Liao and Y. Liu et al., 2012. Differential genomic changes caused by cholesterol-and PUFA-rich diets in regenerated porcine coronary endothelial cells. Physiol. Genomics, 44: 551-561.
CrossRef  |  PubMed  |  Direct Link  |  
32:   Leung, P.T., Y. Wang, S.S. Mak, W.C. Ng and K.M. Leung, 2011. Differential proteomic responses in hepatopancreas and adductor muscles of the green-lipped mussel Perna viridis to stresses induced by cadmium and hydrogen peroxide. Aquat. Toxicol., 105: 49-61.
CrossRef  |  PubMed  |  Direct Link  |  
33:   Li, H., X. Gao, Y. Zhou, N. Li and C. Ge et al., 2011. High level expression, purification and characterization of active fusion human C1q and tumor necrosis factor related protein 2 (hCTRP2) in Escherichia coli. Protein Expression Purif., 79: 1-6.
CrossRef  |  PubMed  |  Direct Link  |  
34:   Li, H., Y. Wang, A. Xu, S. Li, S. Jin and D. Wu, 2011. Large-scale production, purification and bioactivity assay of recombinant human interleukin-6 in the methylotrophic yeast Pichia pastoris. FEMS Yeast Res., 11: 160-167.
CrossRef  |  PubMed  |  Direct Link  |  
35:   Li, H.B., X.F. Gao, Y. Zhou, N. Li and C. Ge et al., 2012. Erratum to High level expression, purification and characterization of active fusion human C1q and tumor necrosis factor related protein 2 (hCTRP2) in Escherichia coli [Protein Express. Purif. 79 (2011) 1-6]. Protein Expression Purif., 82: 253-253.
CrossRef  |  Direct Link  |  
36:   Li, Z, Y. Wang and P.M. Vanhoutte, 2011. Epigallocatechin gallate elicits contractions of the isolated aorta of the aged spontaneously hypertensive rat. Basic Clin. Pharmacol. Toxicol., 109: 47-55.
CrossRef  |  PubMed  |  Direct Link  |  
37:   Li, Z., Y. Wang and P.M. Vanhoutte, 2011. Upregulation of heme oxygenase 1 by hemin impairs endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Hypertension, 58: 926-934.
CrossRef  |  PubMed  |  
38:   Liang, C.F., J.T. Liu, Y. Wang, A. Xu and P.M. Vanhoutte, 2013. Toll-Like receptor 4 mutation protects obese mice against endothelial dysfunction by decreasing NADPH oxidase isoforms 1 and 4. Arterioscler. Thromb. Vasc. Biol., 33: 777-784.
CrossRef  |  Direct Link  |  
39:   Liang, Y., B. Huang, E. Song, B. Bai and Y. Wang, 2014. Constitutive activation of AMPK α1 in vascular endothelium promotes high fat diet-induced fatty liver injury: Role of cyclooxygenase-2 induction. Br. J. Pharmacol., 171: 498-508.
CrossRef  |  Direct Link  |  
40:   Lin, Z., H. Tian, K.S. Lam, S. Lin and R.C. Hoo et al., 2013. Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metab., 17: 779-789.
CrossRef  |  Direct Link  |  
41:   Lithander, F.E., G.F. Keogh, Y. Wang, G.J. Cooper and T.B. Mulvey et al., 2008. No evidence of an effect of alterations in dietary Fatty acids on fasting adiponectin over 3 weeks. Obesity, 16: 592-599.
CrossRef  |  PubMed  |  
42:   Liu, J., A. Xu, K.S. Lam, N.S. Wong, J. Chen, P.R. Shepherd and Y. Wang, 2013. Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: Role of LDL receptor upregulation. Oncotarget, 4: 1804-1818.
PubMed  |  
43:   Liu, J., J.B. Lam, K.H. Chow, A. Xu, K.S. Lam, R.T. Moon and Y. Wang, 2008. Adiponectin stimulates Wnt inhibitory factor-1 expression through epigenetic regulations involving the transcription factor specificity protein 1. Carcinogenesis, 29: 2195-2202.
CrossRef  |  PubMed  |  
44:   Liu, J.T., E. Song, A. Xu, T. Berger and T.W. Mak et al., 2012. Lipocalin-2 deficiency prevents endothelial dysfunction associated with dietary obesity: Role of cytochrome P450 2C inhibition. Br. J. Pharmacol., 165: 520-531.
CrossRef  |  PubMed  |  Direct Link  |  
45:   Liu, L., F.M. Siu, C.M. Che, A. Xu and Y. Wang, 2012. Akt blocks the tumor suppressor activity of LKB1 by promoting phosphorylation-dependent nuclear retention through 14-3-3 proteins. Am. J. Transl. Res., 4: 175-186.
PubMed  |  
46:   Liu, L., Y. Wang, K.S. Lam and A. Xu, 2008. Moderate wine consumption in the prevention of metabolic syndrome and its related medical complications. Endocr. Metab. Immune Disord. Drug Targets, 8: 89-98.
CrossRef  |  PubMed  |  
47:   Liu, X., X. Huang, W. Lin, D. Wang and Y. Diao et al., 2011. New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein. Bioorg. Med. Chem. Lett., 21: 2949-2952.
CrossRef  |  PubMed  |  Direct Link  |  
48:   Palanivel, R., X. Fang, M. Park, M. Eguchi and S. Pallan et al., 2007. Globular and full-length forms of adiponectin mediate specific changes in glucose and fatty acid uptake and metabolism in cardiomyocytes. Cardiovasc. Res., 75: 148-157.
PubMed  |  
49:   Poppitt, S.D., F.E. Leahy, G.F. Keogh, Y. Wang and T.B. Mulvey et al., 2006. Effect of high-fat meals and fatty acid saturation on postprandial levels of the hormones ghrelin and leptin in healthy men. Eur. J. Clin. Nutr., 60: 77-84.
PubMed  |  
50:   Poppitt, S.D., G.F. Keogh, F.E. Lithander, Y. Wang and T.B. Mulvey et al., 2008. Postprandial response of adiponectin, interleukin-6, tumor necrosis factor-alpha and C-reactive protein to a high-fat dietary load. Nutrition, 24: 322-329.
CrossRef  |  PubMed  |  Direct Link  |  
51:   Radjainia, M., B. Huang, B. Bai, M. Schmitz and S.H. Yang et al., 2012. A highly conserved tryptophan in the N-Terminal variable domain regulates disulfide bond formation and oligomeric assembly of adiponectin. FEBS J., 279: 2495-2507.
CrossRef  |  PubMed  |  Direct Link  |  
52:   Radjainia, M., Y. Wang and A.K. Mitra, 2008. Structural polymorphism of oligomeric adiponectin visualized by electron microscopy. J. Mol. Biol., 381: 419-430.
CrossRef  |  
53:   Ruotsalainen, H., M. Risteli, C. Wang, Y. Wang and M. Karppinen et al., 2012. The activities of Lysyl Hydroxylase 3 (LH3) regulate the amount and oligomerization status of adiponectin. PLoS One, Vol. 7. 10.1371/journal.pone.0050045.
CrossRef  |  PubMed  |  
54:   Samaranayake, Y.H., B.P. Cheung, Y. Wang, J.Y. Yau, K.W. Yeung and L.P. Samaranayake, 2013. Fluconazole resistance in Candida glabrata is associated with increased bud formation and metallothionein production. J. Med. Microbiol., 62: 303-318.
CrossRef  |  PubMed  |  Direct Link  |  
55:   Seneviratne, C., Y. Wang, L. Jin, Y. Abiko and L. Samaranayake, 2008. Stress response proteins contribute to the higher antifungal resistance of C. glabrata biofilms. Proteomics, 8: 2936-2947.
56:   Seneviratne, C.J., Y. Wang, L. Jin, S.S. Wong, T.D. Herath and L.P. Samaranayake1, 2012. Unraveling the resistance of microbial biofilms: Has proteomics been helpful? Proteomics, 12: 651-665.
CrossRef  |  PubMed  |  Direct Link  |  
57:   Seneviratne, C.J., Y. Wang, L. Jin, Y. Abiko and L.P. Samaranayake, 2010. Proteomics of drug resistance in Candida Glabrata biofilms. Proteomics, 10: 1444-1454.
CrossRef  |  PubMed  |  Direct Link  |  
58:   Tian, X.Y., W.T. Wong, A. Xu, Y. Lu and Y. Zhang et al., 2012. Uncoupling protein-2 protects endothelial function in diet-induced obese mice. Circ. Res., 110: 1211-1216.
CrossRef  |  PubMed  |  
59:   Tso, A.W., A. Xu, P.C. Sham, N.M. Wat and Y. Wang et al., 2007. Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: A 10-year prospective study in a Chinese cohort. Diabetes Care, 30: 2667-2672.
PubMed  |  
60:   Wang, Y. and J. Seneviratne, 2008. Biomarker discovery in clinical proteomics: Strategies for exposing low abundant proteins. Curr. Proteomics, 5: 104-114.
CrossRef  |  
61:   Wang, Y., 2012. Small lipid-binding proteins in regulating endothelial and vascular functions: focusing on adipocyte fatty acid binding protein and lipocalin-2. Br. J. Pharmacol., 165: 603-621.
CrossRef  |  PubMed  |  Direct Link  |  
62:   Wang, Y., A. Xu and G.J. Cooper, 1999. Amylin evokes phosphorylation of P20 in rat skeletal muscle. FEBS Lett., 457: 149-152.
CrossRef  |  PubMed  |  Direct Link  |  
63:   Wang, Y., A. Xu and G.J. Cooper, 1999. Phosphorylation of P20 is associated with the actions of insulin in rat skeletal muscle. Biochem. J., 344: 971-976.
Direct Link  |  
64:   Wang, Y., A. Xu, C. Knight, L.Y. Xu and G.J. Cooper, 2002. Glycosylation of several conserved hydroxylysines at the collagenous domain enhances the insulin sensitizing activity of adiponectin. J. Biol. Chem., 277: 19521-19529.
65:   Wang, Y., A. Xu, J. Ye, E.W. Kraegen, C. Tse and G.J. Cooper, 2001. Alteration in phosphorylation of P20 is associated with insulin resistance. Diabetes, 50: 1821-1827.
PubMed  |  
66:   Wang, Y., A. Xu, R.B. Pearson and G.J. Cooper, 1999. Insulin and insulin antagonists evoke phosphorylation of P20 at serine 157 and serine 16 respectively in rat skeletal muscle. FEBS Lett., 462: 25-30.
CrossRef  |  PubMed  |  Direct Link  |  
67:   Wang, Y., C. Xu, Y. Liang and P.M. Vanhoutte, 2012. SIRT1 in metabolic syndrome: Where to target matters. Pharmacol. Ther., 136: 305-318.
CrossRef  |  PubMed  |  Direct Link  |  
68:   Wang, Y., G. Lu, W. Wong, H. Vliegenthart and G.J. Gerwig et al., 2004. Proteomic and functional characterization of endogenous adiponectin purified from fetal bovine serum. Proteomics, 4: 3933-3942.
CrossRef  |  PubMed  |  Direct Link  |  
69:   Wang, Y., J.B. Lam, K.S. Lam, J. Liu and M.C. Lam et al., 2006. Adiponectin modulates the glycogen synthase kinase-3β/β-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice. Cancer Res., 66: 11462-11470.
PubMed  |  
70:   Wang, Y., K. Cheng, K.S.L. Lam, D. Wu and Y. Wang et al., 2011. APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice. Diabetes, 60: 3044-3054.
CrossRef  |  PubMed  |  
71:   Wang, Y., K.S. Lam and A. Xu, 2006. Adiponectin as a therapeutic target for obesity-related metabolic and cardiovascular disorders. Drug Dev. Res., 67: 677-686.
CrossRef  |  Direct Link  |  
72:   Wang, Y., K.S. Lam and A. Xu, 2007. Adiponectin as a negative regulator in obesity-related mammary carcinogenesis. Cell Res., 17: 280-282.
CrossRef  |  PubMed  |  Direct Link  |  
73:   Wang, Y., K.S. Lam, E.W. Kraegen, G. Sweeney and J. Zhang et al., 2007. Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance and hyperglycemia in humans. Clin. Chem., 53: 34-41.
PubMed  |  
74:   Wang, Y., K.S. Lam, J.B. Lam, M.C. Lam, P.T. Leung, M.Y. Zhou and A. Xu, 2007. Overexpression of Angiopoietin-like Protein 4 alters mitochondria activities and modulates methionine metabolic cycle in the liver tissues of db/db diabetic mice. Mol. Endocrinol., 21: 972-986.
PubMed  |  
75:   Wang, Y., K.S. Lam, J.Y. Xu, G. Lu, L.Y. Xu, G.J. Cooper and A. Xu, 2005. Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner. J. Biol. Chem., 280: 18341-18347.
PubMed  |  
76:   Wang, Y., K.S. Lam, L. Chan, K.W. Chan and J.B. Lam et al., 2006. Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex. J. Biol. Chem., 281: 16391-16400.
PubMed  |  
77:   Wang, Y., K.S. Lam, M.H. Yau and A. Xu, 2008. Post-Translational modifications of adiponectin: Mechanisms and functional implications. Biochem. J., 409: 623-633.
CrossRef  |  PubMed  |  
78:   Wang, Y., L.Y. Xu, K.S. Lam, G. Lu, G.J. Cooper and A. Xu, 2006. Proteomic characterization of human serum proteins associated with the fat-derived hormone adiponectin. Proteomics, 6: 3862-3870.
CrossRef  |  PubMed  |  Direct Link  |  
79:   Wang, Y., Y. Liang and P.M. Vanhoutte, 2011. SIRT1 and AMPK in regulating mammalian senescence: A critical review and a working model. FEBS Lett., 585: 986-994.
CrossRef  |  PubMed  |  Direct Link  |  
80:   Wen, L., Y. Yang, Y. Wang, A. Xu, D. Wu and Y. Chen, 2010. Appl1 is essential for the survival of Xenopus pancreas, duodenum and stomach progenitor cells. Dev. Dyn., 239: 2198-2207.
CrossRef  |  PubMed  |  Direct Link  |  
81:   Williams, G.A., K.E. Callon, M. Watson, J.L. Costa and Y. Ding et al., 2011. Skeletal phenotype of the leptin receptor-deficient db/db mouse. J. Bone Miner. Res., 26: 1698-1709.
CrossRef  |  PubMed  |  Direct Link  |  
82:   Williams, G.A., Y. Wang, K.E. Callon, M. Watson and J.M. Lin et al., 2009. In vitro and in vivo effects of adiponectin on bone. Endocrinology, 150: 3603-3610.
CrossRef  |  PubMed  |  
83:   Wong, W.T., X.Y. Tian, A. Xu, J. Yu and C.W. Lau et al., 2011. Adiponectin is required for PPARγ mediated improvement of endothelial function in diabetic mice. Cell Metab., 14: 104-115.
84:   Woo, Y.C., A. Xu, Y. Wang and K.S. Lam, 2013. Fibroblast growth factor 21 as an emerging metabolic regulator: Clinical perspectives. Clin. Endocrinol., 78: 489-496.
CrossRef  |  PubMed  |  Direct Link  |  
85:   Xu, A., A.W. Tso, B.M. Cheung, Y. Wang and N.M. Wat et al., 2007. Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: A 5-year prospective study. Circulation, 115: 1537-1543.
PubMed  |  
86:   Xu, A., H. Wang, R.L. Hoo, G. Sweeney and P.M. Vanhoutte et al., 2009. Selective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese mice. Endocrinology, 150: 625-633.
CrossRef  |  PubMed  |  
87:   Xu, A., K.L. Choi, Y. Wang, C. Bogardus, L. Xu and G.J. Cooper, 2002. Identification of novel putative membrane proteins selectively expressed during adipose conversion of 3T3-L1 cells. Biochem. Biophys. Res. Commun., 293: 1161-1167.
CrossRef  |  PubMed  |  Direct Link  |  
88:   Xu, A., K.W. Chan, R.L. Hoo, Y. Wang and K.C. Tan et al., 2005. Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes. J. Biol. Chem., 280: 18073-18080.
PubMed  |  
89:   Xu, A., L.C. Wong, Y. Wang, J.Y. Xu, G.J. Cooper and K.S. Lam, 2004. Chronic treatment with growth hormone stimulates adiponectin gene expression in 3T3-L1 adipocytes. FEBS Lett., 572: 129-134.
CrossRef  |  PubMed  |  Direct Link  |  
90:   Xu, A., M.C. Lam, K.W. Chan, Y. Wang and J. Zhang et al., 2005. Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice. Proc. Natl. Acad. Sci., 102: 6086-6091.
PubMed  |  
91:   Xu, A., Y. Wang, H. Keshaw, L.Y. Xu, K.S.L. Lam and G.J.S. Cooper, 2003. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J. Clin. Invest., 112: 91-100.
CrossRef  |  
92:   Xu, A., Y. Wang, J.Y. Xu, D. Stejskal and S. Tam et al., 2006. Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome. Clin. Chem., 52: 405-413.
PubMed  |  
93:   Xu, A., Y. Wang, K.S. Lam and P.M. Vanhoutte, 2010. Vascular actions of adipokines molecular mechanisms and therapeutic implications. Adv. Pharmacol., 60: 229-255.
CrossRef  |  PubMed  |  
94:   Xu, A., Y. Wang, L.Y. Xu and R.S. Gilmour, 2001. Nuclear translocation of protein Kinase C is responsible for the termination of insulin growth factor I-induced activation of nuclear phospholipase C β1 in Swiss 3T3 cells. J. Biol. Chem., 276: 14980-14986.
95:   Xu, C., B. Bai, P. Fan, Y. Cai and B. Huang et al., 2013. Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice. Am. J. Transl. Res., 5: 412-426.
PubMed  |  
96:   Xu, G., J. Ahn, S. Chang, M. Eguchi and A. Ogier et al., 2012. Lipocalin-2 induces cardiomyocyte apoptosis by increasing intracellular iron accumulation. J. Biol. Chem., 287: 4808-4817.
CrossRef  |  Direct Link  |  
97:   Yang, B., D. Ye and Y. Wang, 2013. Caspase-3 as a therapeutic target for heart failure. Expert Opin. Ther. Targets, 17: 255-263.
CrossRef  |  PubMed  |  
98:   Yang, B., P. Fan, A. Xu, K.S.L. Lam and T. Berger et al., 2012. Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: Restoration of mitochondrial function and phospholipids remodeling. Am. J. Transl. Res., 4: 60-71.
PubMed  |  
99:   Yang, S., Y. Kuang, H. Li, Y. Liu and X. Hui et al., 2013. Enhanced production of recombinant secretory proteins in Pichia pastoris by optimizing Kex2 P1' site. PLOS One, Vol. 8. 10.1371/journal.pone.0075347.
CrossRef  |  
100:   Yang, Y.H., Y. Wang, K.S. Lam, M.H. Yau and K.K. Cheng et al., 2008. Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4. Arterioscler. Thromb. Vasc. Biol., 28: 835-840.
CrossRef  |  PubMed  |  
101:   Yau, M.H., Y. Wang, K.S. Lam, J. Zhang, D. Wu and A. Xu, 2009. A highly conserved motif within the NH2-terminal coiled-coil domain of angiopoietin-like protein 4 confers its inhibitory effects on lipoprotein lipase by disrupting the enzyme dimerization. J. Biol. Chem., 284: 11942-11952.
CrossRef  |  PubMed  |  
102:   Ye, D., F.Y. Li, K.S. Lam, H. Li and W. Jia et al., 2012. Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice. Gut, 61: 1058-1067.
CrossRef  |  PubMed  |  
103:   Yeung, C.Y., A.W. Tso, A. Xu, Y. Wang and Y.C. Woo et al., 2013. Pro-inflammatory adipokines as predictors of incident cancers in a chinese cohort of low obesity prevalence in Hong Kong. PLoS One, Vol. 8. 10.1371/journal.pone.0078594.
CrossRef  |  PubMed  |  
104:   Yeung, D.C., K.S. Lam, Y. Wang, A.W. Tso and A. Xu, 2009. Serum zinc-α2-glycoprotein correlates with adiposity, triglycerides and the key components of the metabolic syndrome in Chinese subjects. J. Clin. Endocrinol. Metab., 94: 2531-2536.
CrossRef  |  PubMed  |  
105:   Yeung, D.C., Y. Wang, A. Xu, S.C. Cheung and N.M. Wat et al., 2008. Epidermal fatty-acid-binding protein: A new circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis. Eur. Heart J., 29: 2156-2163.
CrossRef  |  PubMed  |  
106:   Yu, H., F. Xia, K.S. Lam, Y. Wang and Y. Bao et al., 2011. Circadian rhythm of circulating fibroblast growth factor 21 is related to diurnal changes in fatty acids in humans. Clin. Chem., 57: 691-700.
CrossRef  |  PubMed  |  
107:   Zhang, X., K.S. Lam, H. Ye, S.K. Chung, M. Zhou, Y. Wang and A. Xu, 2010. Adipose tissue-specific inhibition of hypoxia-inducible factor 1α induces obesity and glucose intolerance by impeding energy expenditure in mice. J. Biol. Chem., 285: 32869-32877.
CrossRef  |  PubMed  |  Direct Link  |  
108:   Zhou, M., A. Xu, K.S. Lam, P.K. Tam and C.M. Che et al., 2010. Rosiglitazone promotes fatty acyl CoA accumulation and excessive glycogen storage in livers of mice without adiponectin. J. Hepatol., 53: 1108-1116.
CrossRef  |  PubMed  |  Direct Link  |  
109:   Zhou, M., A. Xu, P.K. Tam, K.S. Lam and B. Huang et al., 2012. Upregulation of UCP2 by adiponectin: The involvement of mitochondrial superoxide and hnRNP K. PLoS One, Vol. 7. 10.1371/journal.pone.0032349.
CrossRef  |  PubMed  |  
110:   Zhou, M., A. Xu, P.K. Tam, K.S. Lam and L. Chan et al., 2008. Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury. Hepatology, 48: 1087-1096.
CrossRef  |  PubMed  |  Direct Link  |  
111:   Zu, Y., L. Liu, M.Y. Lee, C. Xu and Y. Liang et al., 2010. SIRT1 Promotes proliferation and prevents senescence through targeting lkb1 in primary porcine aortic endothelial cells. Circ. Res., 106: 1384-1393.
CrossRef  |  PubMed  |