Dr. Yanling  Zhao
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Dr. Yanling Zhao

Research Director
Academy of Military Medical Science, China


Highest Degree
Ph.D. in Pharmacology and Toxicology from Academy of Military Medicine Sciences, Beijing, China

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Biography

Dr. Yanling Zhao is currently working as Professor of Pharmacology and Deputy Director at Military Hospital, Beijing, China. She obtained her PhD in Pharmacology from Academy of Military Medical Science, China in 2007. Her searching field mainly focuses on Pharmacology. The familiar professional field is Anti-Hepatitis Drug Screening, development and its Mechanism study. The Antiviral Effect, Liver Protection, Immune Regulation, Detoxification of Drug in Liver are generally and systemically explored. Meanwhile, the mechanism of the drug is also examined by advanced Molecular Biological technique in my field. Besides, the property of chinese herbal medicine, including toxicity, efficacy and formulae regulation, is widely researched. Dr. Yanling received honors includes, The Second Prize of National Science and Technology Progress, Second and Third Prize of PLA Science and Technology Progress, The Second Prize of China Association of Chinese Medicine Science and Technology, and The Second Prize of Peking Science and Technology Progress. She is also serving as reviewer in journals. She is professional member of following societies, Executive Director World Federation of Chinese Medicine Societies, and China Medicine Education Association, China Association of Chinese Medicine. She has published 48 articles in journals contributed as author/co-author.

Area of Interest:

Pharmacology and Toxicology
100%
Traditional Chinese Medicine
62%
Chinese Herbal Medicine
90%
Pharmacology
75%
Liver Toxicology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Zhao, Y., X. Ma, J. Wang, R. Wen and L. Jia et al., 2015. Large dose means significant effect-dose and effect relationship of Chi-Dan-Tui-Huang decoction on alpha-naphthylisothiocyanate-induced cholestatic hepatitis in rats. BMC Complement. Alternat. Med., Vol. 15. 10.1186/s12906-015-0637-0.
    CrossRef  |  Direct Link  |  
  2. Zhao, Y., X. Ma, J. Wang, R. Wen and L. Jia et al., 2015. Large dose means significant effect - dose and effect relationship of Chi-Dan-Tui-Huang decoction on alpha-naphthylisothiocyanate-induced cholestatic hepatitis in rats. BMC Complement. Altern. Med., 15: 1-11.
    CrossRef  |  Direct Link  |  
  3. Zhao, Y., S. Liu, F. Qu, J. Wang and Y. Hu et al., 2015. Microcalorimetry coupled with principal component analysis for investigating the anti-Staphylococcus aureus effects of different extracted fractions from Dracontomelon dao. J. Thermal Anal. Calorimetry, 120: 913-920.
    CrossRef  |  Direct Link  |  
  4. Zhao, Y., X. Ma, J. Wang, Y. Zhu and R. Li et al., 2014. Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α through mTOR-dependent pathway. Fitoterapia, 99: 318-327.
    CrossRef  |  Direct Link  |  
  5. Zhao, Y., X. Ma, J. Wang, X. He and Y. Hu et al., 2014. Curcumin protects against CCl4-induced liver fibrosis in rats by inhibiting HIF-1α through an ERK-dependent pathway. Molecules, 19: 18767-18780.
    CrossRef  |  Direct Link  |  
  6. Zhao, Y., J. Wang, X. Sun, L. Jia and J. Li et al., 2014. Microcalorimetry coupled with chemometric techniques for toxicity evaluation of Radix Aconiti Lateralis Preparata (Fuzi) and its processed products on Escherichia coli. Applied Microbiol. Biotechnol., 98: 437-444.
    CrossRef  |  Direct Link  |  
  7. Zhao, Y., L. Jia, J. Wang, M. Gong and P. Zhang et al., 2013. Microcalorimetry with correspondence analysis for studying the antibacterial effect of ephedrine on Escherichia coli. Thermochimi. Acta, 557: 50-54.
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  8. Zhao, Y., G. Zhou, J. Wang, L. Jia and P. Zhang et al., 2013. Paeoniflorin protects against ANIT-induced cholestasis by ameliorating oxidative stress in rats. Food Chem. Toxicol., 58: 242-248.
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  9. Zeng, L., Z. Ma, Y. Zhao, L. Zhang and R. Li et al., 2013. The protective and toxic effects of rhubarb tannins and anthraquinones in treating hexavalent chromium-injured rats: The Yin/Yang actions of rhubarb. J. Hazard. Mater., 246: 1-9.
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  10. Sun, Z., Y. Zhao, T. Liu, X. Sun, R. Li, P. Zhang and X. Xiao, 2013. Spectrum-effect relationships between UPLC fingerprints and bioactivities of five Aconitum L. plants. Thermochimi. Acta, 558: 61-66.
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  11. Ma, Z.J., Q. Li, J.B. Wang, Y.L. Zhao and Y.W. Zhong et al., 2013. Combining oxymatrine or matrine with lamivudine increased its antireplication effect against the hepatitis B virus in vitro. Evid.-Based Complement. Alternat. Med., Vol. 2013. 10.1155/2013/186573.
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  12. Liu, T., Y. Zhao, J. Wang, X. Zhou and Z. Sun et al., 2013. Action of crude Radix Aconiti Lateralis (Fuzi) and its processed products on splenic lymphocytes growth investigated by microcalorimetry. Thermochimi. Acta, 571: 1-7.
    CrossRef  |  Direct Link  |  
  13. Zhao, Y., L. Jia, H. Yang, J. Wang and P. Zhang et al., 2012. Influence of Nonpolar Substances on the Extraction Efficiency of Six Alkaloids in Zoagumhwan Investigated by Ultra Performance Liquid Chromatography and Photodiode Array Detection. Mol., 17: 13844-13855.
    CrossRef  |  Direct Link  |  
  14. Xiaoyan, X., Z. Yanling, K. Weijun, Y. Dan and H. Yumei et al., 2012. Effects of angle and nail animal drugs on Bacillus subtilis growth investigated by microcalorimetry combined with chemometric analysis. J. Therm. Anal. Calorim., 109: 381-385.
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  15. Xiaoyan, X., Z. Yanling, K. Weijun, W. Jiabo and J. Lei et al., 2012. Evaluation of the liver protection and toxicity of Da-Huang-Zhe-Chong Pill in rats. Pharm. Biol., 50: 344-350.
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  16. Sun, Z.Y., Y.L. Zhao, J.B. Wang, R.S. Li, S.S. Wei, F.J. Jiang and X.H. Xiao, 2012. Study on hot property of Aconiti Lateralis Radix Praeparata and its compatibility with Zingiberis rhizoma based on animal temperature tropism. Chin. Herbal Med., 4: 294-300.
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  17. Sun, Z Y., Y.L. Zhao, J.B. Wang, L. Zhang and S.S. Wei et al., 2012. Research on Fuzi based on animal thermotropism behavior to discover if it has fewer hot characteristics without Ganjiang. J. Tradit. Chin. Med., 32: 208-214.
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  18. Qin, Y., J. Wang, Y. Zhao, L. Shan and B. Li et al., 2012. Establishment of a bioassay for the toxicity evaluation and quality control of Aconitum herbs. J. Hazard. Mater., 199: 350-357.
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  19. Kong, W.J., X.Y. Xing , X.H. Xiao, Y.L. Zhao and J.H. Wei et al., 2012. Effect of berberine on Escherichia coli, Bacillus subtilis, and their mixtures as determined by isothermal microcalorimetry. Applied Microbiol. Biotechnol., 96: 503-510.
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  20. Han, Y., D. Yan, Y. Zhao, C. Peng and X. Xiao, 2012. Toxic effects of protoberberine alkaloids from Rhizoma Coptidis on Tetrahymena thermophila BF5 growth based on microcalorimetry. J. Therm. Anal. Calorim., 108: 341-346.
    CrossRef  |  Direct Link  |  
  21. Zhao, Y.L., J.B. Wang, X.H. Xiao, H.P. Zhao and C.P. Zhou et al., 2011. Study on the cold and hot properties of medicinal herbs by thermotropism in mice behavior. J. Ethnopharmacol., 133: 980-985.
    CrossRef  |  
  22. Zhao, Y.L., J.B. Wang, P. Zhang, R.S. Li and X.H. Xiao, 2011. Microcalorimetric study of the opposing effects of ginsenosides Rg1 and Rb1 on the growth of mice splenic lymphocytes. J. Therm. Anal. Calorim., 104: 357-363.
    CrossRef  |  Direct Link  |  
  23. Zhao, Y.L., J.B. Wang, P. Zhang, L.M. Shan, R.S. Li and X.H. Xiao, 2011. Study of the quantitative quantity-activity relationship of fourginsenosides on splenic lymphocytes growth by microcalorimetry. J. Therm. Anal. Calorim., 104: 375-382.
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  24. Zhao, Y.L., G.D. Zhou, H.B. Yang, J.B. Wang, L.M. Shan, R.S. Li and X.H. Xiao, 2011. Rhein protects against acetaminophen-induced hepatic and renal toxicity. Food Chem. Toxicol., 49: 1705-1710.
    CrossRef  |  Direct Link  |  
  25. Zhao, Y., J.B. Wang, L.M. Shan, R.S. Li, D. Yan and X.H. Xiao, 2011. Activity of ginsenoside Rh2 on the growth of mice splenic lymphocytes investigated by microcalorimetry and factor analysis. J. Therm. Anal. Calorim., 105: 1037-1041.
    CrossRef  |  Direct Link  |  
  26. Xiaoyan, X., Z. Yanling, K. Weijun, W. Jiabo and J. Lei et al., 2011. Investigation of the dose-time-response relationships of rhubarb extract on carbon tetrachloride-induced liver injury in rats. J. Ethnopharmacol., 135: 575-581.
    CrossRef  |  Direct Link  |  
  27. Wang, J.B., H.P. Zhao, Y.L. Zhao, C. Jin and D.J. Liu et al., 2011. Hepatotoxicity or hepatoprotection? Pattern recognition for the paradoxical effect of the Chinese herb Rheum palmatum L. in treating rat liver injury. PloS ONE, Vol. 6. 10.1371/journal.pone.0024498.
    CrossRef  |  Direct Link  |  
  28. WEI, S., Y. ZHAO, F. JIANG, L. JIA and Y. ZHU et al., 2011. "Dose-Effect-Response" Relationships of Paeoniae Radix Rubra on Alpha-Naphthylisothiocyanate-Induced Acute Cholestatic Hepatitis in Rats. Chin. Herbal Med., 3: 301-303.
  29. Qin, Y., J. Wang, W. Kong, Y. Zhao and H. Yang et al., 2011. The diarrhoeogenic and antidiarrhoeal bidirectional effects of rhubarb and its potential mechanism. J. Ethnopharmacol., 133: 1096-1102.
    CrossRef  |  Direct Link  |  
  30. Kong, W., Z. Li, X. Xiao and Y. Zhao, 2011. Preliminary screening for extraction techniques and bioactive fraction of Coptidis Rhizoma based on microcalorimetry. Pharm. Biol., 49: 362-368.
    CrossRef  |  Direct Link  |  
  31. Jiang, F., Y. Zhao, J. Wang, S. Wei and Z. Wei et al., 2011. Comparative pharmacokinetic study of paeoniflorin and albiflorin after oral administration of Radix Paeoniae Rubra in normal rats and the acute cholestasis hepatitis rats. Fitoterapia, 83: 415-421.
    CrossRef  |  Direct Link  |  
  32. Fang, F., J. Wang, Y. Zhao, C. Jin and W. Kong et al., 2011. A comparative study on the tissue distributions of rhubarb anthraquinones in normal and CCl4-injured rats orally administered rhubarb extract. J. Ethnopharmacol., 137: 1492-1497.
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  33. Zhang, L., F.Y. Li, J.B. Wang, Y.L. Zhao, Y. Li and X.H. Xiao, 2010. Preliminary evidence-based medical study on TCM therapeutic principle expelling heat with cold herbs based on chronic hepatitis B cases China. J. Tradit. Chin. Med. Pharm., 25: 2194-2198.
  34. Yanling, Z., Y. Dan, W. Jiabo, Z. Ping and X. Xiaohe, 2010. Anti-fungal effect of berberine on Candida albicans by microcalorimetry with correspondence analysis. J. Therm. Anal. Calorim., 102: 49-55.
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  35. Kong, W., Z. Li, X. Xiao, Y. Zhao and P. Zhang, 2010. Activity of berberine on Shigella dysenteriae investigated by microcalorimetry and multivariate analysis. J. Therm. Anal. Calorim., 102: 331-336.
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  36. Kong, W., Z. Li, X. Xiao and Y. Zhao, 2010. Quality control for Coptidis rhizoma through the determination of five alkaloids by HPLC-ELSD coupled with chemometrics. Nat. Prod. Res., 24: 1616-1629.
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  37. Kong, W., Z. Li, X. Xiao and Y. Zhao, 2010. Microcalorimetric investigation of the toxic action of berberine on Tetrahymena thermophila BF5. J. Basic Microbiol., 50: 436-441.
    CrossRef  |  Direct Link  |  
  38. Kong, W., C. Jin, X. Xiao, Y. Zhao, W. Liu, Z. Li and P. Zhang, 2010. Determination of multicomponent contents in Calculus bovis by ultra-performance liquid chromatography-evaporative light scattering detection and its application for quality control. J. Seperation Sci., 33: 1518-1527.
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  39. Kong, W., C. Jin, X. Xiao, Y. Zhao and Z. Li et al., 2010. Comparative study of effects of two bile acid derivatives on Staphylococcus aureus by multiple analytical methods. J. Hazard. Mater., 179: 742-747.
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  40. Zhao, H.P., Y.L. Zhao, J.B. Wang, H.B. Li and Y.S. Ren et al., 2009. Expression of the difference between the Cold (Han) and Hot (Re) natures of traditional Chinese medicines (Strobal and Rhubarb) based on the cold/hot plate differentiating assay. Sci. China Ser. C: Life Sci., 52: 1192-1197.
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  41. Yan-Ling, Z., W. Jiabo, Z. Guangde, S. limei and X. xiao-He, 2009. Investigations of Free Anthraquines from Rhubarb Against a-Naphylisothiocynate-induced Cholestatic Liver Injury in Rats. Basic Clin. Pharmacol. Toxicol., 104: 463-469.
  42. Yan-Ling, Z., S. Wenli, S. limei, W. Jiabo, Z. Haiping and X. xiao-He, 2009. Differences in Effects of Zuojin Pills and Its Similar Formulaes on Wei Cold Model in Rats. Chin. J. Integr. Med., 15: 1-6.
  43. Kong, W.J., Y.L. Zhao, X.H. Xiao, Z.L. Li, C.Jin and H.B. Li, 2009. Investigation of the anti-fungal activity of coptisine on Candida albicans growth by microcalorimetry combined with principal component analysis. J. Appl. Microbiol., 107: 1072-1080.
    CrossRef  |  Direct Link  |  
  44. Kong, W., Y. Zhao, X. Xiao, Z. Li and Y. Ren, 2009. Action of palmatine on Tetrahymena thermophila BF5 growth investigated by microcalorimetry. J. Hazard. Mater., 168: 609-613.
    CrossRef  |  Direct Link  |  
  45. Kong, W., Y. Zhao, X. Xiao, J. Wang and H. Li et al., 2009. Spectrum-effect relationships between ultra performance liquid chromatography fingerprints and anti-bacterial activities of Rhizoma coptidis. Anal. Chim. Acta, 634: 279-285.
    CrossRef  |  Direct Link  |  
  46. Kong, W., Y. Zhao, X. Xiao, J. Cheng, L. Yi and Z. Li, 2009. Comparison of Anti-bacterial Activity of Four Kinds of Alkaloids in Rhizoma Coptidis Based on Microcalorimetry. Chin. J. Chem., 27: 1186-1190.
    CrossRef  |  Direct Link  |  
  47. Kong, W., Y. Zhao, X. Xiao, C. Jin and Z. Li, 2009. Quantitative and chemical fingerprint analysis for quality control of Rhizoma Coptidischinensis based on UPLC-PAD combined with chemometrics methods. Phytomedicine, 16: 950-959.
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  48. Jiabo, W., Z. Yanling, X. Xiaohe, L. Huifang, Z. Haiping, Z. Ping and J. Cheng, 2009. Assessment of the renal protection and hepatotoxicity of rhubarb extract in rats. J. Ethnopharmacol., 124: 18-25.
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