Dr. Yong Lin
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Dr. Yong Lin

Researcher
Lovelace Respiratory Research Institute, USA

Highest Degree
Ph.D. in Molecular Biology from Kanazawa University, Japan

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Area of Interest:

Biomedical Sciences
100%
Signal Transduction
62%
Lung Cancer
90%
Apoptosis
75%
Chemotherapy
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
28
Abstracts
0

Selected Publications

  1. Chen, W., Z. Li, L. Bai and Y. Lin, 2011. NF-kappaB in lung cancer, a carcinogenesis mediator and a prevention and therapy target. Front. Biosci., 16: 1172-1185.
    PubMed  |  Direct Link  |  
  2. Xu, J., F. Xu and Y. Lin, 2010. Cigarette smoke synergize LPS-induced TNFa and IL1b secretion from macrophages through SP-mediated NF-kB activation. Am. J. Respir. Cell Mol. Biol., .
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  3. Lin, Y., L. Bai, W. Chen and S. Xu, 2010. The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapy. Expert Opin. Ther. Targets, 14: 45-55.
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  4. Kamarajan, P., J. Bunek, Y. Lin, N. D'Silva, G. Nunez and Y.L. Kapila, 2010. Receptor-interacting protein shuttles between cell death and survival signaling pathways. Mol. Biol. Cell, 21: 481-488.
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  5. Chen, W., L. Bai, X. Wang, S. Xu, S.A. Belinsky and Y. Lin, 2010. Acquired activation of the Akt/cyclooxygenase-2/Mcl-1 pathway renders lung cancer cells resistant to apoptosis. Mol. Pharmacol., 77: 416-423.
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  6. Bai, L., W. Chen, W. Chen, X. Wang, H. Tang and Y. Lin, 2009. IKKβ-mediated nuclear factor-κB activation attenuates smac mimetic-induced apoptosis in cancer cells. Mol. Cancer Ther., 8: 1636-1645.
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  7. Wang, X., W. Chen, W. Zeng, L. Bai, Y. Tesfaigzi, S.A. Belinsky and Y. Lin, 2008. Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells. Mol. Cancer Ther., 7: 1156-1163.
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  8. Lin, Y., R. Shi, X. Wang and H.M. Shen, 2008. Luteolin, a flavonoid with potential for cancer prevention and therapy. Curr. Cancer Drug Targets, 8: 634-646.
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  9. Zhang, S., Y. Lin, Y.S. Kim, M.P. Hande, Z.G. Liu and H.M. Shen, 2007. C-Jun N-terminal kinase mediates hydrogen peroxide-induced cell death via sustained poly(ADP-ribose) polymerase-1 activation. Cell Death Differ., 14: 1001-1010.
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  10. Wang, X., W. Chen and Y. Lin, 2007. Sensitization of TNF-induced cytotoxicity in lung cancer cells by concurrent suppression of the NF-kappaB and Akt pathways. Biochem. Biophys. Res. Commun., 355: 807-812.
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  11. Ju, W., X. Wang, W. Chen, H. Shi, S.A. Belinsky and Y. Lin, 2007. A critical role of luteolin-induced reactive oxygen Species in blockage of tumor necrosis factor-activated nuclear factor-kB pathway and sensitization of apoptosis in lung cancer cells. Mol. Pharmacol., 71: 1381-1388.
    PubMed  |  Direct Link  |  
  12. Chen, W., X. Wang, J. Zhuang, L. Zhang and Y. Lin, 2007. Induction of death receptor 5 and suppression of survivin contribute to sensitization of TRAIL-induced cytotoxicity by quercetin in non-small cell lung cancer cells. Carcinogenesis, 28: 2114-2121.
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  13. Yang, Q., Y. Kim, Y. Lin, J. Lewis, L. Neckers and Z.G. Liu, 2006. Tumour necrosis factor receptor 1 mediates endoplasmic reticulum stress‐induced activation of the MAP kinase JNK. EMBO Rep., 7: 622-627.
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  14. Wang, X., W. Ju, J. Renouard, J. Aden, S.A. Belinsky and Y. Lin, 2006. 17-Allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer cell death by blocking the nuclear factor-kappaB pathway. Cancer Res., 66: 1089-1095.
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  15. Lin, Y., Q. Yang, X. Wang and Z.G. Liu, 2006. The essential role of the death domain kinase receptor-interacting protein in insulin growth factor-I-induced c-Jun N-terminal kinase activation. J. Biol. Chem., 281: 23525-23532.
    PubMed  |  Direct Link  |  
  16. Yang, Q., W. Huang, C. Jozwik, Y. Lin and M. Glasman et al., 2005. Cardiac glycosides inhibit TNF-α/NF-κB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor. Proc. Natl. Acad. Sci. USA., 102: 9631-9636.
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  17. Shen, H.M., Y. Lin, J. Jin, L. Chang, M. Karin, J. Zhang and Z.G. Liu, 2004. Essential roles of receptor-Interacting protein and TRAF2 in oxidative stress-Induced cell death. Mol. Cell Biol., 24: 5914-5922.
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  18. Lin, Y., S. Choksi, H.M. Shen, Q.F. Yang and G.M. Hur et al., 2004. Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation. J. Biol. Chem., 279: 10822-10828.
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  19. Huang, Q., J. Yang, Y. Lin, C. Walker, J. Cheng, Z.G. Liu and B. Su, 2004. Differential regulation of interleukin 1 receptor and toll-like receptor signaling by MEKK3. Nat. Immunol., 5: 98-103.
    PubMed  |  Direct Link  |  
  20. Wei, W., J.X. Gu, C.Q. Zhu, F.Y. Sun, D. Dorjsuren, Y. Lin and S. Murakami, 2003. Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP). Cell Res., 13: 111-120.
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  21. Qin, S., H. Tang, L.S. Zhao, F. He, Y. Lin, L. Liu and X.M. He, 2003. Cloning of HBsAg-encoded genes in different vectors and their expression in eukaryotic cells. World J. Gastroenterol., 9: 1111-1113.
    PubMed  |  Direct Link  |  
  22. Lin, Y., J. Ryan, J. Lewis, M.A. Wani, J.B. Lingrel and Z.G. Liu, 2003. TRAF2 exerts Its antiapoptotic effect by regulating the expression of kruppel-like factor LKLF Mol. Cell Biol., 23: 5849-5856.
    PubMed  |  Direct Link  |  
  23. Hur, G.M., J. Lewis, Q. Yang, Y. Lin, H. Nakano, S. Nedospasov and Z.G. Liu, 2003. The death domain kinase RIP has an essential role in DNA damage-induced NF-κB activation. Genes Dev., 17: 873-882.
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  24. Devin, A., Y. Lin and Z.G. Liu, 2003. The role of the death-domain kinase RIP in tumour-necrosis-factor-induced activation of mitogen-activated protein kinases. EMBO Rep., 4: 623-627.
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  25. Yang, J., Y. Lin, Z. Guo, H. Huang, W. Liao, Z.G. Liu and B. Su, 2001. The essential for TNF-induced NF-kB activation. Nat. Immunol., 2: 620-624.
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  26. Wei, W., D. Dorjsuren, Y. Lin, W. Qin, T. Nomura, N. Hayashi and S. Murakami, 2001. Direct interaction between the subunit RAP30 of transcription factor IIF (TFIIF) and RNA polymerase subunit 5, which contributes to the association between TFIIF and RNA polymerase II. J. Biol. Chem., 276: 12266-12273.
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  27. Qin, W., T. Yamashita, Y. Shirota, Y. Lin, W. Wei and S. Murakami, 2001. Mutational analysis of the structure and functions of hepatitis C virus RNA-dependent RNA polymerase. Hepatology, 33: 728-737.
    PubMed  |  Direct Link  |  
  28. Devin, A., Y. Lin, S. Yamaoka, Z. Li, M. Karin and Z.G. Liu, 2001. The α and β subunits of Iκβ Kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF. Mol. Cell Biol., 21: 3986-3994.
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