Dr. Gang Xie
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Dr. Gang Xie

Research Assistant
Stony Brook University, USA

Highest Degree
Ph.D. in Chemistry and Biochemistry from South Dakota School of Mines and Technology, USA

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Area of Interest:

Chemistry
100%
Biochemistry
62%
Drug Metabolism
90%
Enzymology
75%
Protein Chemistry
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
38
Abstracts
1

Selected Publications

  1. Xie, G., T. Nie, G.G. Mackenzie, Y. Sun and L. Huang et al., 2012. The metabolism and pharmacokinetics of phospho-sulindac (OXT-328) and the effect of difluoromethylornithine. Br. J. Pharmacol., 165: 2152-2166.
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  2. Xie, G., C.C. Wong, K.W. Cheng, L. Huang and P.P. Constantinides et al., 2012. Regioselective Oxidation of Phospho-Nsaids by Human Cytochrome P450 and Flavin Monooxygenase Isoforms: Implications for their Pharmacokinetic Properties and Safety. Br. J. Pharmacol., 167: 222-232.
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  3. Wong, C.C., K.W. Cheng, G. Xie, D. Zhou and C.H. Zhu et al., 2012. Carboxylesterases 1 And 2 Hydrolyze Phospho-Nonsteroidal Anti-Inflammatory Drugs: Relevance to their Pharmacological Activity. J. Pharmacol. Exp. Ther., 340: 422-432.
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  4. Xie, G., Y. Sun, T. Nie, G.G. Mackenzie and L. Huang et al., 2011. Phospho-ibuprofen (MDC-917) is a novel agent against colon cancer: Efficacy, metabolism, and pharmacokinetics in mouse models. J. Pharmacol. Exp. Ther., 337: 876-886.
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  5. Mackenzie, G.G., N. Ouyang, G. Xie, K. Vrankova and L Huang et al., 2011. Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice. Cancer Prev. Res., 4: 1052-1060.
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  6. Huang, L., N. Ouyang, Y. Sun, G. Xie, F. Johnson, D. Komninou and B. Rigas, 2011. The novel phospho-non-steroidal anti-inflammatory drugs, OXT-328, MDC-22 and MDC-917, inhibit adjuvant-induced arthritis in rats. Br. J. Pharm., 162: 1521-1533.
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  7. Huang, L., G.G. Mackenzie, Y. Sun, N. Ouyang and G. Xie et al., 2011. Chemotherapeutic Properties of Phospho-Nonsteroidal Anti-Inflammatory Drugs, A New Class of Anticancer Compounds. Cancer Res., 71: 7617-7627.
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  8. Xie, G. and T.P. West, 2010. Citric acid production by aspergillus niger on corn distillers' grains with solubles. Res. J. Microbiol., 5: 515-520.
  9. Mackenzie, G.G., Y. Sun, L. Huang, G. Xie and N. Ouyang et al., 2010. A novel sulindac derivative (MDC-1231) is a safe and effective agent for the prevention of colon cancer. Gastroenterology, 139: 1320-1332.
  10. Huang, L., C. Zhu, Y. Sun, G. Xie, G. Mackenzie, D. Komninou and B. Rigas, 2010. Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: a redox/polyamine-dependent effect. Carcinogenesis, 31: 1982-1990.
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  11. Xie, G. and T.P. West, 2009. Citric acid production by Aspergillus niger ATCC 9142 from a treated ethanol fermentation co-product using solid-state fermentation. Lett. Appl. Microbiol., 48: 639-644.
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  12. Schepetkin, I.A., G. Xie, M.A. Jutila and M.T. Quinn, 2009. Complement-fixing activity of fulvic acid from Shilajit and other natural sources. Phytother. Res., 23: 373-384.
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  13. Zhu, H, G. Xie, M. Liu, J.S. Olson, M. Fabian, D.M. Dooley and B. Lei, 2008. Pathway for heme uptake from human methemoglobin by the Iron-regulated surface determinants system of Staphylococcus aureus. J. Biol. Chem., 283: 18450-18460.
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  14. Xie, G., M. Liu, H. Zhu and B. Lei, 2008. Esterase SeE of Streptococcus equi ssp. equi is a novel nonspecific carboxylic ester hydrolase. FEMS Microbiol. Lett., 289: 181-186.
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  15. Xie, G., I.A. Schepetkin, D.W. Siemsen, L.N. Kirpotina, J.A. Wiley and M.T. Quinn, 2008. Fractionation and characterization of biologically-active polysaccharides from Artemisia tripartita. Phytochemistry, 69: 1359-1371.
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  16. Schepetkin, I.A., G. Xie, L.N. Kirpotina, R.A. Klein, M.A. Jutila and M.T. Quinn, 2008. Macrophage immunomodulatory activity of polysaccharides isolated from Opuntia polyacantha. Int. Immunopharmacol., 8: 1455-1466.
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  17. Liu, M., W.N. Tanaka, H. Zhu, G. Xie, D.M. Dooley and B. Lei, 2008. Direct hemin transfer from IsdA to IsdC in the iron-regulated surface determinant (Isd) heme acquisition system of staphylococcus aureus. J. Biol. Chem., 283: 6668-6676.
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  18. Liu, M., M.J. McClure, H. Zhu, G. Xie and B. Lei, 2008. The two-component regulatory system vicRK is important to virulence of Streptococcus equi Subspecies equi. Open Microbiol. J., 2: 89-93.
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  19. Xie, G., I.A. Schepetkin and M.T. Quinn, 2007. Immunomodulatory activity of acidic polysaccharides isolated from Tanacetum vulgare L. Int. Immunopharmacol., 7: 1639-1650.
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  20. Xie, G. and T.P. West, 2007. Citric acid production by Aspergillus niger on the ethanol dry milling coproduct thin stillage. Res. J. Microbiol., 2: 678-683.
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  21. Xie, G. and T.P. West, 2007. Citric Acid production by Aspergillus niger on condensed corn distillers solubles. Res. J. Microbiol., 2: 481-485.
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  22. Xie, G. and T.P. West, 2006. Comparison of citric acid production by Aspergillus niger ATCC 9029 and ATCC 12846 on corn distillers` grains with solubles. Res. J. Microbiol., 1: 540-545.
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  23. Xie, G. and T.P. West, 2006. Citric acid production by selected strains of Aspergillus niger ATCC 9029 and ATCC 12846 on corn distillers grains with solubles. Res. J. Microbiol., 1: 540-545.
  24. Xie, G. and T.P. West, 2006. Citric acid production by Aspergillus niger on wet corn distillers grains. Lett. Applied Microbiol., 43: 269-273.
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  25. West, T.P., B. Reed and G. Xie, 2004. Fungal citric acid production on distillers grains. Curr. Trends Microbiol., 1: 97-102.
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