Dr. Zhao-Ying Liu
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Dr. Zhao-Ying Liu

Research Scientist
Hunan Agricultural University, China

Highest Degree
Ph.D. in Veterinary Pharmacology and Toxicology from Huazhong Agricultural University, China

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Area of Interest:

Animal and Veterinary Sciences
100%
Veterinary Bacteriology
62%
Medical Entomology
90%
Pharmacology
75%
Toxicological Pathology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Yang, K., Y.J. Zhou, F.H. Chen, X.M. Long, G.W. Kuang, Z.L. Sun and Z.Y. Liu, 2017. Determination of baclofen residue in muscle, liver, kidney and fat of swine by liquid chromatography-tandem mass spectrometry. Food Anal. Methods, 10: 3866-3873.
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  2. Xiao, S., Y.J. Huang, Z.L. Sun and Z.Y. Liu, 2017. Structural elucidation of koumine metabolites by accurate mass measurements using high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom., 31: 309-314.
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  3. Liu, Y.C., S. Xiao, K. Yang, L. Ling, Z.L. Sun and Z.Y. Liu, 2017. Comprehensive identification and structural characterization of target components from Gelsemium elegans by high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry based on accurate mass databases combined with MS/MS spectra. J. Mass Spectrom., 52: 378-396.
    CrossRef  |  Direct Link  |  
  4. Liu, Y.C., L. Lin, P. Cheng, Z.L. Sun, Y. Wu and Z.Y. Liu, 2017. Fingerprint analysis of Gelsemium elegans by HPLC followed by the targeted identification of chemical constituents using HPLC coupled with quadrupole-time-of-flight mass spectrometry. Fitoterapia, 121: 94-105.
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  5. Wang, X., M.A. Martinez, G. Cheng, Z. Liu and L. Huang et al., 2016. The critical role of oxidative stress in the toxicity and metabolism of quinoxaline 1,4-di-N-oxides in vitro and in vivo. Drug Metab. Rev., 48: 159-182.
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  6. Liu, Z., Y. Huang, H. Xie, W. Liu, J. Zeng and P. Cheng, 2016. A novel C-C radical-radical coupling reaction promoted by visible light: Facile synthesis of 6-substituted N-methyl 5,6-dihydrobenzophenanthridine alkaloids. RSC Adv., 6: 50500-50505.
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  7. Li, Q., Z. Liu, S. Kolli, K. Wetz, N. Griffith and M.J. Poi, 2016. Stability of extemporaneous erlotinib, lapatinib and imatinib oral suspensions. Am. J. Health-Syst. Pharm., 73: 1331-1337.
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  8. Huang, Y.J., S. Xiao, Z.L. Sun, J.G. Zeng, Y.S. Liu and Z.Y. Liu, 2016. Identification of allocryptopine and protopine metabolites in rat liver S9 by high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom., 30: 1549-1559.
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  9. Zhang, D.S., Y.Y. Li, X.J. Chen, Y.J. Li, Z.Y. Liu, W.J. Xie and Z.L. Sun, 2015. BCL2 promotor methylation and miR-15a/16-1 upregulation is associated with sanguinarine-induced apoptotic death in rat HSC-T6 cells. J. Pharmacol. Sci., 127: 135-144.
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  10. Liu, Z.Y., K. Yang, F.H. Chen, X.M. Long, Y.B. Deng, G.W. Kuang and Z.L. Sun, 2015. Development of a rapid method for the confirmatory analysis of flunixin residue in animal tissues using liquid chromatography-tandem mass spectrometry. Food Anal. Methods, 8: 352-362.
    CrossRef  |  Direct Link  |  
  11. Zhang, D.S., Z.Y. Liu, Y.J. Li and Z.L. Sun, 2014. NQO1 involves in the imine bond reduction of sanguinarine and recombinant adeno-associated virus mediated NQO1 overexpression decreases sanguinarine-induced cytotoxicity in rat BRL cells. Toxicol. Lett., 225: 119-129.
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  12. Li, J., L. Huang, X. Wang, Y. Pan and Z. Liu et al., 2014. Metabolic disposition and excretion of quinocetone in rats, pigs, broilers and carp. Food Chem. Toxicol., 69: 109-119.
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  13. Zhang, H.H., Y. Wu, Z.L. Sun and Z.Y. Liu, 2013. Identification of sanguinarine metabolites in pig liver preparations by accurate mass measurements using electrospray ionization hybrid ion trap/time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom., 27: 979-984.
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  14. Yu, C.H., Z.Y. Liu, L.S. Sun, Y.J. Li, D.S. Zhang, R.T. Pan and Z.L. Sun, 2013. Effect of danofloxacin on reactive oxygen species production, lipid peroxidation and antioxidant enzyme activities in kidney tubular epithelial cell line, LLC-PK1. Basic Clin. Pharmacol. Toxicol., 113: 377-384.
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  15. Yang, J., Z. Liu, M. Li and X. Qiu, 2013. Hydroxylation of quinocetone and carbadox is mediated by CYP1As in the chicken (Gallus gallus). Comp. Biochem. Physiol. Part C: Toxicol. Pharmacol., 158: 84-90.
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  16. Wu, Y., Z.Y. Liu, Y. Cao, X.J. Chen, J.G. Zeng and Z.L. Sun, 2013. Reductive metabolism of the sanguinarine iminium bond by rat liver preparations. Pharmacol. Rep., 65: 1391-1400.
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  17. Liu, Z.Y. and Z.L. Sun, 2013. The metabolism of carbadox, olaquindox, mequindox, quinocetone and cyadox: An overview. Med. Chem., 9: 1017-1027.
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  18. Zhang, D.S., Z.Y. Liu, X.J. Chen, G.W. Kuang, R.T. Pan and Z.L. Sun, 2012. Investigation of ANGPTL3 expression, exon sequence and promotor methylation between Ningxiang and Changbai pigs. Afr. Health Sci., 12: 522-529.
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  19. Yao, M., M. Dai, Z. Liu, W. Cui and D. Li et al., 2012. mRNA expression profiles of P450 3A enzymes in the liver and small intestine of the domestic pig. Res. Vet. Sci., 93: 360-365.
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  20. Tao, Y., D. Chen, H. Yu, L. Huang and Z. Liu et al., 2012. Simultaneous determination of 15 aminoglycoside(s) residues in animal derived foods by automated solid-phase extraction and liquid chromatography-tandem mass spectrometry. Food Chem., 135: 676-683.
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  21. Liu, Z.Y., Y. Wu, Z.L. Sun and L. Wan, 2012. Characterization of in vitro metabolites of trimethoprim and diaveridine in pig liver microsomes by liquid chromatography combined with hybrid ion trap/time-of-flight mass spectrometry. Biomed. Chromatogr., 26: 1101-1108.
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  22. Liu, Z.Y., C.H. Yu, L. Wan and Z.L. Sun, 2012. Fragmentation study of five trichothecenes using electrospray hybrid ion trap/time-of-flight mass spectrometry with accurate mass measurements. Int. J. Mass Spectrom., 309: 133-140.
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  23. Liu, Z.Y., 2012. An introduction to hybrid ion trap/time-of-flight mass spectrometry coupled with liquid chromatography applied to drug metabolism studies. J. Mass Spectrom., 47: 1627-1642.
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  24. Chen, X.J., X. Bai, P. Mai, J. Cai and Z.Y. Liu et al., 2012. Angiopoietin-like protein 3 expression is down-regulated in experimentally pregnant toxemic goats. J. Integr. Agric., 11: 1181-1188.
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  25. Yu, H., Y. Tao, D. Chen, Y. Wang and L. Huang et al., 2011. Development of a high performance liquid chromatography method and a liquid chromatography-tandem mass spectrometry method with the pressurized liquid extraction for the quantification and confirmation of sulfonamides in the foods of animal origin. J. Chromatogr. B, 879: 2653-2662.
    CrossRef  |  Direct Link  |  
  26. Yao, M., M. Dai, Z. Liu, L. Huang and D. Chen et al., 2011. Comparison of the substrate kinetics of pig CYP3A29 with pig liver microsomes and human CYP3A4. Biosci. Rep., 31: 211-220.
    CrossRef  |  Direct Link  |  
  27. Wu, Q., L. Huang, Z. Liu, M. Yao, Y. Wang, M. Dai and Z. Yuan, 2011. A comparison of hepatic in vitro metabolism of T-2 toxin in rats, pigs, chickens and carp. Xenobiotica, 41: 863-873.
    CrossRef  |  Direct Link  |  
  28. Wang, X., X.J. Huang, A. Ihsan, Z.Y. Liu and L.L. Huang et al., 2011. Metabolites and JAK/STAT pathway were involved in the liver and spleen damage in male Wistar rats fed with mequindox. Toxicology, 280: 126-134.
    CrossRef  |  Direct Link  |  
  29. Liu, Z.Y., Y.F. Tao, D.M. Chen, X. Wang and Z.H. Yuan, 2011. Identification of carbadox metabolites formed by liver microsomes from rats, pigs and chickens using high-performance liquid chromatography combined with hybrid ion trap/time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom., 25: 341-348.
    CrossRef  |  Direct Link  |  
  30. Liu, Z.Y., X.N. Zhou, H.H. Zhang, L. Wan and Z.L. Sun, 2011. An integrated method for degradation products detection and characterization using hybrid ion trap/time-of-flight mass spectrometry and data processing techniques: Application to study of the degradation products of danofloxacin under stressed conditions. Anal. Bioanal. Chem., 399: 2475-2486.
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  31. Liu, Z.Y., M.H. Dai, Y.F. Tao, D.M. Chen and Z.H. Yuan, 2011. Inhibition of cytochrome P450 2A participating in coumarin 7-hydroxylation in pig liver microsomes. J. Vet. Pharmacol. Therapeut., 34: 424-429.
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  32. Liu, Z.Y., L.L. Huang, X.N. Zhou, D.M. Chen, Y.F. Tao, H.H. Zhang and Z.H. Yuan, 2011. The metabolism of olaquindox in rats, chickens and pigs. Toxicol. Lett., 200: 24-33.
    CrossRef  |  Direct Link  |  
  33. Liu, Z.Y., H.H. Zhang, X.J. Chen, X.N. Zhou, L. Wan and Z.L. Sun, 2011. Structural elucidation of degradation products of olaquindox under stressed conditions by accurate mass measurements using electrospray ionization hybrid ion trap/time-of-flight mass spectrometry. Int. J. Mass Spectrom., 303: 90-96.
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  34. Liu, Z.Y., D.M. Chen, L.L. Huang, Y.F. Tao, M. Yao and Z.H. Yuan, 2011. In vitro biotransformation and investigation of metabolic enzymes possibly responsible for the metabolism of bisdesoxyolaquindox in the liver fractions of rats, chicken and pigs. Toxicology, 279: 155-166.
    CrossRef  |  Direct Link  |  
  35. Ihsan, A., X. Wang, Z. Liu, Y. Wang and X. Huang et al., 2011. Long-term mequindox treatment induced endocrine and reproductive toxicity via oxidative stress in male Wistar rats. Toxicol. Applied Pharmacol., 252: 281-288.
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  36. Chen, D., Y. Tao, Z. Liu, H. Zhang and Z. Liu et al., 2011. Development of a liquid chromatography-tandem mass spectrometry with pressurized liquid extraction for determination of glucocorticoid residues in edible tissues. J. Chromatogr. B, 879: 174-180.
    CrossRef  |  Direct Link  |  
  37. Tao, Y., H. Yu, D. Chen, Z.Y. Liu and D. Yang et al., 2010. Determination of sodium nifurstyrenate and nitrovin residues in edible food by liquid chromatography-tandem mass spectrometry after ultrasound-assisted extraction. J. Chromatogr. B, 878: 3415-3420.
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  38. Liu, Z.Y., L.L. Huang, D.M. Chen, M.H. Dai, Y.F. Tao, Y.L. Wang and Z.H. Yuan, 2010. Application of electrospray ionization hybrid ion trap/time-of-flight mass spectrometry in the rapid characterization of quinocetone metabolites formed in vitro. Anal. Bioanal. Chem., 396: 1259-1271.
    CrossRef  |  Direct Link  |  
  39. Liu, Z.Y., L.L. Huang, D.M. Chen, M.H. Dai, Y.F. Tao and Z.H. Yuan, 2010. The metabolism and N-oxide reduction of olaquindox in liver preparations of rats, pigs and chicken. Toxicol. Lett., 195: 51-59.
    CrossRef  |  Direct Link  |  
  40. Liu, Z.Y., L.L. Huang, D.M. Chen and Z.H. Yuan, 2010. Metabolism of mequindox in liver microsomes of rats, chicken and pigs. Rapid Commun. Mass Spectrom., 24: 909-918.
    CrossRef  |  Direct Link  |  
  41. Chen, D., Y. Tao, Z. Liu, Z. Liu, Y. Wang, L. Huang and Z. Yuan, 2010. Development of a Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) method for the quantification of glucocorticoid residues in edible tissues of swine, cattle, sheep and chicken. Food Addit. Contam., 27: 1363-1371.
    CrossRef  |  Direct Link  |  
  42. Chen, D., Y. Tao, Z. Liu, Z. Liu and L. Huang et al., 2010. Development of a high-performance liquid chromatography method to monitor the residues of benzimidazoles in bovine milk. J. Chromatogr. B, 878: 2928-2932.
    CrossRef  |  Direct Link  |  
  43. Liu, Z., L. Huang, M. Dai, D. Chen, Y. Tao, Y. Wang and Z. Yuan, 2009. Metabolism of cyadox in rat, chicken and pig liver microsomes and identification of metabolites by accurate mass measurements using electrospray ionization hybrid ion trap/time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom., 23: 2026-2034.
    CrossRef  |  Direct Link  |  
  44. Liu, Z., L. Huang, M. Dai, D. Chen, Y. Wang, Y. Tao and Z. Yuan, 2008. Metabolism of olaquindox in rat liver microsomes: Structural elucidation of metabolites by high-performance liquid chromatography combined with ion trap/time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom., 22: 1009-1016.
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