Dr. Xiaoxu Zhou
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Dr. Xiaoxu Zhou

Research Fellow
Brown University, USA

Highest Degree
M.D. in Clinical Medicine from Harbin Medical University, China

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Area of Interest:

Biomedical Sciences
100%
Clinical Biochemistry
62%
Physiology
90%
Medicine
75%
Clinical Diagnostic
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Yan, W., D. Li and X. Zhou, 2017. Pravastatin attenuates the action of the ETS domain‐containing protein ELK1 to prevent atherosclerosis in apolipoprotein E‐knockout mice via modulation of extracellular signal‐regulated kinase 1/2 signal pathway. Clin. Exp. Pharmacol. Physiol., 44: 344-352.
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  2. Xiong, C., X. Zang, X. Zhou, L. Liu and M.V. Masucci et al., 2017. Pharmacological inhibition of Src kinase protects against acute kidney injury in a murine model of renal ischemia/reperfusion. Oncotarget, 8: 31238-31253.
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  3. Zhou, X., X. Zang, M. Ponnusamy, M.V. Masucci and E. Tolbert et al., 2016. Enhancer of zeste homolog 2 inhibition attenuates renal fibrosis by maintaining smad7 and phosphatase and tensin homolog expression.` J. Am. Soc. Nephrol., 27 : 2092-2108.
  4. Yan, Y., L. Ma, X. Zhou, M. Ponnusamy, J. Tang, M.A. Zhuang and S. Zhuang, 2016. Src inhibition blocks renal interstitial fibroblast activation and ameliorates renal fibrosis. Kidney Int., 89: 68-81.
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  5. Xiong, C., M.V. Masucci, X. Zhou, N. Liu, X. Zang, E. Tolbert and S. Zhuang, 2016. Pharmacological targeting of BET proteins inhibits renal fibroblast activation and alleviates renal fibrosis. Oncotarget, 7: 69291-69308.
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  6. Yan, Y., J. Bai, X. Zhou, J. Tang, C. Jiang, E. Tolbert and S. Zhuang, 2015. P2X7 receptor inhibition protects against ischemic acute kidney injury in mice. Am. J. Physiol. Cell Physiol., 308: C463-C472.
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  7. Ponnusamy, M., M.A. Zhuang, X. Zhou, E. Tolbert, G. Bayliss, T.C. Zhao and S. Zhuang, 2015. Activation of Sirtuin-1 promotes renal fibroblast activation and aggravates renal fibrogenesis. J. Pharmacol. Exp. Ther., 354: 142-151.
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  8. Ponnusamy, M., X. Zhou, Y. Yan, J. Tang, E. Tolbert, T.C. Zhao and S. Zhuang, 2014. Blocking sirtuin 1 and 2 inhibits renal interstitial fibroblast activation and attenuates renal interstitial fibrosis in obstructive nephropathy. J. Pharmacol. Exp. Ther., 350: 243-256.
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  9. Zhou, X., D. Li, M.B. Resnick, J. Wands and W. Cao, 2013. NADPH oxidase NOX5-S and nuclear factor κB1 mediate acid-induced microsomal prostaglandin E synthase-1 expression in Barrett's esophageal adenocarcinoma cells. Mol. Pharmacol., 83: 978-990.
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  10. Zhou, X., D. Li, M.B. Resnick, J. Behar, J. Wands and W. Cao, 2011. Signaling in H2O2-induced increase in cell proliferation in Barrett's esophageal adenocarcinoma cells. J. Pharmacol. Exp. Therapeut., 339: 218-227.
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  11. An, Y., H. Xin, W. Yan and X. Zhou, 2011. Amelioration of cisplatin-induced nephrotoxicity by pravastatin in mice. Exp. Toxicol. Pathol., 63: 215-219.
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  12. Zhou, X.X., P.J. Gao and B.G. Sun, 2009. Pravastatin attenuates interferon‐γ action via modulation of stat1 to prevent aortic atherosclerosis in apolipoprotein e‐knockout mice. Clin. Exp. Pharmacol. Physiol., 36: 373-379.
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  13. Zhou, X.X., P.J. Gao, B.G. Sun and Z. Jian-jun, 2008. ANTI- oxidative mechanisms of pravastatin preventing aortic atherosclerosis in apoe knockout mice: Role of p38 mapk pathway. J. Shanghai Second Med. Univ., 2: 135-141.
  14. Zhou, X., D. Li, W. Yan and W. Li, 2008. Pravastatin prevents aortic atherosclerosis via modulation of Signal Transduction and Activation of Transcription 3 (STAT3) to attenuate Interleukin-6 (IL-6) action in ApoE knockout mice. Int. J. Mol. Sci., 9: 2253-2264.
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