Hi, I am Karl Wah-Keung Tsim, My LiveDNA is 86.5955
 
   
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Dr. Karl Wah-Keung Tsim
 
Highest Degree: Ph.D. in Molecular Neurobiology from University of Cambridge, UK
 
Institute: Hong Kong University of Science and Technology, China
 
Area of Interest: Pharmacology and Toxicology
  •   Pharmacology
  •   Peptide Protein Research
  •   Molecular Cell Endocrinology
  •   Neuroscience
 
URL: http://livedna.org/86.5955
 
My SELECTED Publications
1:   Barnard, E.A., D.M.W. Beeson, M.G. Darlison, S.J. Moss, W.R. Randall and K.W.K. Tsim, 1989. Regulation of Acetylcholine Receptors and Acetylcholinesterase in the Innervation of Skeletal Muscle. In: Neuromuscular Junction, Sellin, L.C., R. Libelius and S. Thesleff (Eds.). Elsevier, Amsterdam, pp: 499 514.
2:   Barnard, E.A., J. Simon, K.W.K. Tsim, A.K. Filippov and D.A. Brown, 2003. Signalling pathways and ion channel regulations of P2Y receptors. Drug. Dev. Res., 59: 36-48.
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3:   Bi, C.W., H.Q. Xie, L. Xu, J. Li and A.W. Cheung et al., 2010. Fo Shou San, an ancient herbal decoction prepared from Rhizoma Chuanxiong and Radix Angelicae Sinensis, stimulates the production of hemoglobin and erythropoietin in cultured cells. Planta Med., 76: 1525-1529.
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4:   Bi, C.W.C., H.Q.H. Xie, L. Xu, J. Li and A.W.H. Cheung et al., 2010. Fo shou san an ancient herbal decoction prepared from rhizoma chuanxiong and radix angelicae sinensis, stimulates the production of hemoglobin and erythropoietin in cultured cells. Planta Med., 78: 122-127.
CrossRef  |  
5:   Bi, C.W.C., L. Xu, X.Y. Tian, J. Liu and K.Y.Z. Zheng et al., 2012. Fo Shou San, an ancient Chinese herbal decoction, protects endothelial function through increasing.endothelial nitric oxide synthase activity. PLoS ONE, Vol. 10.1371/journal.pone.0051670.
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6:   Bian, Y., P. Li, Z. Gao, Y. Wang, K. Zhou, K.W.K. Tsim, T.T.X. Dong, 2001. Application of RAPD in the taxonomy of the genus Fritillaria. J. Chin Med. Materials., 232: 13-16.
7:   Cai, Z.H., P. Li, S.L. Gao, T.T.X. Dong and K.W.K. Tsim, 2000. Physiology and biochemical analysis of cultured F. puqiensis during bulb organogenesis. J. Wuhan Botanical Res., 17: 314-318.
8:   Cai, Z.H., P. Li, S.L. Gao, T.X. Dong and K.W.K. Tsim, 1999. Isozyme electrophoresis in bulb organogenesis of Fritillaria in vitro. China J. Chinese Mate. Med., 24: 16-20.
9:   Cai, Z.H., P. Li, S.L. Gao, T.X. Dong and K.W.K. Tsim, 1999. Studies on tissue culture of Fritillaria puqiensis. J. Nanjing Normal Univ., 22: 175-179.
10:   Cai, Z.H., P. Li, T.T.X. Dong and K.W.K. Tsim, 1999. Molecular diversity of 5S-rRNA spacer domain in Fritillaria species revealed by PCR analysis. Planta Med., 65: 360-364.
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11:   Cai, Z.H., P. Li, T.T.X. Dong and K.W.K. Tsim, 2000. Molecular biological identification of the Chinese drug ''Beimu'' (Bulbus Fritillariae). Acta Pharam Sinica, 35: 309-312.
12:   Carles, M., M.K. Cheung, S. Moganti, T.T. Dong, K.W. Tsim, N.Y. Ip and N.J. Sucher, 2005. A DNA microarray for the authentication of toxic traditional Chinese medicinal plants. Planta Med., 71: 580-584.
PubMed  |  Direct Link  |  
13:   Carles, M., T. Lee, S. Moganti, R. Lenigk and K.W. Tsim et al., 2001. Chips and Qi: Microcomponent-based analysis in traditional Chinese medicine. Fresenius J. Anal. Chem., 371: 190-194.
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14:   Chan, G.K.L., K.Y. Zhu, D.J.Y. Chou, A.J.Y. Guo, T.T.X. Dong and K.W.K. Tsim, 2013. Surveillance of nitrite level in cubilose: Evaluation of removal method and proposed origin of contamination. Food Control, 34: 637-644.
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15:   Chan, K.N., C.C. Lau, K.L. Chow, K.M. Ko, K.W.K. Tsim and K.M. Ng, 2009. Effect of extraction solvent on the bioactivity of an herbal formulation. Indu. Eng. Chem. Res., 48: 4852-4857.
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16:   Chan, P.H., K.Y.Z. Zheng, K.W.K. Tsim and H.H.N. Lam, 2012. Metabonomic analysis of water extracts from Chinese and American ginsengs by 1H nuclear magnetic resonance: Identification of chemical profile for quality control. Chin. Med., Vol. 7. 10.1186/1749-8546-7-25.
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17:   Chan, W.K.B., V.P. Chen, W.K.W. Luk, R.C.Y. Choi and K.W.K. Tsim, 2012. N-linked glycosylation of proline-rich membrane anchor (PRiMA) is not required for assembly and trafficking of globular tetrameric acetylcholinesterase. Neurosci Lett., 523: 71-75.
CrossRef  |  PubMed  |  
18:   Chang, X.L., Z.Y. Jiang, Y.B. Ma, X.M. Zhang, K.W.K. Tsim and J.J. Chen, 2009. Two new compounds from the roots of Ligusticum chuanxiong. J. Asian Nat. Prod. Res., 11: 805-810.
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19:   Chen, J., Z. Li, M. Maiwulanjiang, W.L. Zhang and J.Y.X. Zhan et al., 2013. Chemical and biological assessment of Ziziphus jujuba fruits from China: Different geographical sources and developmental stages. J. Agric. Food Chem., 61: 7315-7324.
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20:   Chen, V.P., H.Q. Xie, W.K. Chan, K.W. Leung and G.K. Chan et al., 2010. The PRiMA-linked cholinesterase tetramers are assembled from homodimers: Hybrid molecules composed of acetylcholinesterase and butyrylcholinesterase dimers are up-regulated during development of chicken brain. J. Biol. Chem., 285: 27265-27278.
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21:   Chen, V.P., H.Q. Xie, W.K.B. Chan, K.W. Leung, R.C.Y. Choi and K.W.K. Tsim, 2010. An induction effect of heat shock on the transcript of globular acetylcholinesterase in NG108-15 cells. Chem. Biol. Interactions, 187: 106-109.
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22:   Chen, V.P., R.C. Choi, W.K. Chan, K.W. Leung and A.J. Guo et al., 2011. The Assembly of Proline-rich Membrane Anchor (PRiMA)-linked Acetylcholinesterase Enzyme: Glycosylation is required for enzymatic activity but not for oligomerization. J. Biol. Chem., 286: 32948-32961.
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23:   Chen, V.P., W.K. Luk, W.K. Chan, K.W. Leung and A.J. Guo et al., 2011. Molecular assembly and biosynthesis of acetylcholinesterase in brain and muscle: The roles of t-peptide, FHB domain and N-linked glycosylation. Front. Mol. Neurosci., Vol. 4. .
PubMed  |  
24:   Cheng, A., L.W. Kong, E.K.K. Tung, N. Siow and R.C.Y. Choi et al., 2003. cDNA encodes Xenopus P2Y(1) nucleotide receptor: Expression at the neuromuscular junctions. NeuroReport, 14: 351-357.
PubMed  |  
25:   Cheng, C.H.K., K.W.K. Tsim, M.K. Wai and R.C.K. Pak, 1984. Rat hepatic prolactin receptor: Pubertal exposure to sex steroid alters responsively to testosterone. Int. J. Peptide Protein Res., 23: 521-527.
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26:   Cheung, J.K.H., J. Li, A.W.H. Cheung, W.Z.M. Li and C.W.C. Bi et al., 2009. Cordysinocan, a polysaccharide isolated from cultured Cordyceps, activates immune responses in cultured T-lymphocytes and macrophages: Signaling cascade and induction of cytokines. J. Ethnopharmacol., 124: 61-68.
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27:   Cheung, J.K.H., S.P. Li and K.W.K. Tsim, 2005. Authentication and quality control of Cordyceps sinensis, a traditional Chinese medicine known as summer-grass winter-worm. Oriental Pharm. Exp. Med., 5: 262-271.
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28:   Chiu, P.Y., H.Y. Leung, A.H. Siu, M.K. Poon, T.T. Dong, W.K. Tsim and K.M. Ko, 2007. Dang-Gui Buxue Tang protects against oxidant injury by enhancing cellular glutathione in H9c2 cells: role of glutathione synthesis and regeneration. Planta Medica., 73: 134-141.
PubMed  |  Direct Link  |  
29:   Choi, R.C., L.Y. Yung, T.T. Dong, D.C. Wan, Y.H. Wong and K.W. Tsim, 1998. The calcitonin gene‐related peptide‐induced acetylcholinesterase synthesis in cultured chick myotubes is mediated by cyclic AMP. J. Neurochem., 71: 152-160.
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30:   Choi, R.C., M.L. Man, K.K. Ling, N.Y. Ip, J. Simon, E.A. Barnard and K.W. Tsim, 2001. Expression of the P2Y1 nucleotide receptor in chick muscle: Its functional role in the regulation of acetylcholinesterase and acetylcholine receptor. J. Neurosci., 21: 9224-9234.
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31:   Choi, R.C., N.L. Siow, A.W. Cheng, K.K. Ling and E.K. Tung et al., 2003. ATP acts via P2Y1 receptors to stimulate acetylcholinesterase and acetylcholine receptor expression: Transduction and transcription control. J. Neurosci., 23: 4445-4456.
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32:   Choi, R.C., N.L. Siow, S.Q. Zhu and K.W. Tsim, 2000. The cAMP-dependent protein kinase mediates the expression of AChE in chick myotubes. NeuroReport, 11: 801-806.
PubMed  |  
33:   Choi, R.C., S.C. Yam, B. Hui, D.C. Wan and K.W. Tsim, 1998. Over-expression of acetylcholinesterase stimulates the expression of agrin in NG108-15 cells. Neurosci. Lett., 248: 17-20.
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34:   Choi, R.C., Z. Jiang, H.Q. Xie, A.W. Cheung and D.T. Lau et al., 2010. Anti-oxidative effects of the biennial flower of Panax notoginseng against H2O2-induced cytotoxicity in cultured PC12 cells. Chin. Med. J., 5: 1-7.
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35:   Choi, R.C.Y., A.K.L. Ting, F.T.C. Lau, H.Q. Xie and K.W. Leung et al., 2007. Calcitonin gene-related peptide induces the expression of acetylcholinesterase-associated collagen ColQ in muscle: A distinction in driving two different promoters between fast-and slow-twitch muscle fibers. J. Neurochem., 102: 1316-1328.
PubMed  |  
36:   Choi, R.C.Y., G.K.Y. Chu, N.L. Siow, A.W.Y. Yung and L.Y. Yung et al., 2013. Activation of UTP-sensitive P2Y2 receptor induces the expression of cholinergic genes in cultured cortical neurons: A signaling cascade triggered by Ca2+ mobilization and ERK phosphorylation. Mol. Pharmacol., 84: 50-61.
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37:   Choi, R.C.Y., J.T.T. Zhu, A.W.Y. Yung, P. Lee and S.L. Xu et al., 2013. Synergistic action of flavonoids, baicalein and daidzein in estrogenic and neuroprotective effects: A development of potential health products and therapeutic drugs against alzheimer's diseas. Evidence Based Complement Alternative Med., Vol. 2013. 10.1155/2013/635694.
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38:   Choi, R.C.Y., J.T.T. Zhu, K.W. Leung, G.K.Y. Chu and H.Q.H. Xie et al., 2010. A flavonol glycoside, isolated from roots of Panax notoginseng, reduces amyloid-β-induced neurotoxicity in cultured neurons: Signaling transduction and drug development for alzheimer's disease. J. Alzheimer Dis., 19: 795-811.
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39:   Choi, R.C.Y., M.K.W. Mok, A.W.H. Cheung, N.L. Siow, H.Q. Xie, K.W.K. Tsim, 2008. Regulation of PRiMA-linked G4 AChE by a cAMP-dependent signaling pathway in cultured rat pheochromocytoma PC12 cells. Chem.Biol. Interact., 175: 76-78.
40:   Choi, R.C.Y., N. Siow, S.Q. Zhu, D.C.C. Wan, Y.H. Wong and K.W.K. Tsim, 2001. The cAMP-mediated expression of acetylcholinesterase in myotubes shows contrary regulation between avian and mammalian enzymes. Mol. Cell. Neurosci., 17: 732-745.
41:   Choi, R.C.Y., Q.T. Gao, A.W.H. Cheung, J.T.T. Zhu and F.T.C. Lau et al., 2011. A Chinese herbal decoction, danggui buxue tang, stimulates proliferation, differentiation and gene expression of cultured osteosarcoma cells: Genomic approach to reveal specific gene activation. Evidence-Based Compl. Altern. Med., Vol. 2011. 10.1093/ecam/nen085.
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42:   Choi, R.C.Y., V.P. Chen, W.K.W. Luk, A.W.Y. Yung, A.M. Ng, T.T.X. Dong and K.W.K. Tsim, 2013. Expression of cAMP-responsive element binding proteins (CREBs) in fast- and slow-twitch muscles: A signaling pathway to account for the synaptic expression of collagen-tailed subunit (ColQ) of acetylcholinesterase at the rat neuromuscular junction. Chem. Biol. Interact., 203: 282-286.
CrossRef  |  PubMed  |  
43:   Choi,R.C.Y., J.Simon, K.W.K. Tsim and E.A. Barnard, 2008. Constitutive and agonist-induced dimerizations of the P2Y1 receptor: Relationship to internalization and scaffolding. J. Biol. Chem., 283: 11050-11063.
CrossRef  |  PubMed  |  Direct Link  |  
44:   Choia, R.C., P.W. Leung, T.T. Donga, D.C. Wan and K.W. Tsima, 1996. Calcitonin gene-related peptide increases the expression of acetylcholinesterase in cultured chick myotubes. Neuroscience let, 217: 165-168.
CrossRef  |  
45:   Chou, G.X., Q.T. Gao, J. Li, R. Duan and A.W.H. Cheung et al., 2007. Identification and quality control of Radix Codonopsis by chemical fingerprint: Evaluation of lobetyolin from different cultivated regions in China. Oriental Pharm. Exp. Med., 6: 293-299.
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46:   Chou, G.X., T.T.X. Dong, K.W.K. Tsim, Z.L. Yu and Z.T. Wang, 2004. Preparation methods for detection of gentiopicrin in Radix Gentianae. Res. Practice Chin. Med., 18: 38-40.
47:   Chou, G.X., T.T.X. Dong, K.W.K. Tsim, Z.T. Wang and Z.L. Yu, 2005. Quantitative detection of gentiopicrin in Radix Gentianae. Shanghai J. Traditional Chin. Med., 39: 53-55.
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48:   Cui, X.M., C.K. Lo, K.L. Yip, T.T.X. Dong and K.W.K. Tsim, 2003. Authentication of Panax notoginseng by 5S-rRNA spacer domain and random amplified polymorphic DNA (RAPD) analysis. Planta Med., 69: 584-586.
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49:   Cui, X.M., L.S. Xu, Q. Wang, Z.J. Chen, T.T.X. Dong and K.W.K. Tsim, 2005. Determination of dencichine in Radix Notoginseng. Chin. Pharm. J., 40: 1017-1019.
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50:   Cui, X.M., T.T.X. Dong, Z.J. Chen and K.W.K. Tsim, 2002. Identification on Panax notoginseng and its adulterants by HPLC fingerprint chromatogram. Chin Trad Herb Drugs, 33: 941-943.
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51:   Cui, X.M., T.X. Dong, Z.J. Chen, C.L. Wang and K.W.K. Tsim, 2002. Studies on the change of polysaccharides in Panax notoginseng collected at different times and from regions. Chin Pharm. J., 37: 819-820.
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52:   Cui. X.M., T.T.X. Dong, W.Z. Huang, Z.J. Chen and K.W.K. Tsim, 2002. Determination of flavonoids in Pana notoginseng. Chin. Trad Herb Drugs, 33: 611-612.
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53:   Ding, K., J.N. Fang, T.T.X. Dong, K.W.K. Tsim and H.M. Wu, 2003. Characterization of a rhamnogalacturonan and a xyloglucan from Nerium indicum and their activities on PC12 pheochromocytoma cells. J. Nat. Prod., 66: 7-10.
PubMed  |  
54:   Dong, T.., X.M. Cui, Z.H. Song, K.J. Zhao, Z.N. Ji, C.K. Lo and K.W. Tsim, 2003. Chemical assessment of roots of Panax notoginseng in China: Regional and seasonal variations in its active constituents. J. Agric. Food Chem., 51: 4617-4623.
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55:   Dong, T.T., J.K. Zhao, G.T. Qiut, N.J. Zhao and D. Ran et al., 2006. Chemical and biological assessment of a Chinese herbal decoction containing radix astragali and radix angelicae sinensis: Determination of drug ratio in having optimized properties. J. Agric. Food Chem., 54: 2767-2774.
CrossRef  |  PubMed  |  Direct Link  |  
56:   Dong, T.T., X.Q. Ma, C. Clarke, Z.H. Song, Z.N. Ji, C.K. Lo and K.W. Tsim, 2003. Phylogeny of Astragalus in China: Molecular evidence from the DNA sequences of 5S rRNA spacer, ITS and 18S rRNA. J. Agric. Food Chem., 51: 6709-6714.
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57:   Dong, T.T.X., C.K. Lo, K.W.K. Tsim, 2001. [The identification of Hippocampus by HPCE]. J. Chin. Med. Materials, 24: 328 -329.
PubMed  |  
58:   Dong, T.T.X., K.J. Zhao, W.Z. Huang, K.W. Leung and K.W.K. Tsim, 2005. Orthogonal array design in optimizing the extraction conditions of active constituents from roots of Panax notoginseng. Phytotherapy Res., 19: 684-688.
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59:   Dong, T.T.X., X.M. Cui, X.Q. Ma and K.W.K. Tsim, 2001. Chemical comparison of Radix Notoginseng (Sanqi) from different regions of China. Analytical. Sci., 17: 467-472.
60:   Dong, X.B., J. Li, Y. Jiang, Y. Zheng, T.T.X. Dong, P.F. Tu K.W.K. Tsim, 2007. Determination of tenuifolin in Tianwang Buxinwan and Guipiwan by HPLC. J. Chinese Materia Medica, 32: 1647-1649.
PubMed  |  Direct Link  |  
61:   Dong, X.B., J. Li, Y. Zheng, T.T.X. Dong and K.W.K. Tsim, 2007. Preparation of tenuifolin from Radix Polygalae for reference substance. Traditional Chin. Drug Res. Clin. Pharmacol., 18: 53-54.
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62:   Du, C.Y.Q., R.C.Y. Choi, K.Y.Z. Zheng, T.T.X. Dong, D.T.W. Lau and K.W.K. Tsim, 2013. Yu Ping Feng San, An ancient Chinese herbal decoction containing Astragali Radix, Atractylodis Macrocephalae Rhizoma and Saposhnikoviae Radix, regulates the release of cytokines in murine macrophages. PLoS One, Vol. 8. 10.1371/journal.pone.0078622.
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63:   Duan, R., R.G. Xue, J. Li, S.H. Yang, T.T.X. Dong and K.W.K. Tsim, 2009. Quality evaluation of radix angelicae sinensis. Mod. Chin. Med., 11: 27-29.
64:   Fu, A.K., F.D. Smith, H. Zhou, A.H. Chu, K.W. Tsim, B.H. Peng and N.Y. Ip, 1999. Xenopus muscle‐specific kinase: Molecular cloning and prominent expression in neural tissues during early embryonic development. Eur. J. Neruosci., 11: 373-382.
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65:   Fu, A.K., W.Y. Fu, J. Cheung, K.W. Tsim, F.C. Ip, J.H. Wang and N.Y. Ip, 2001. Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction. Nat. Neurosci., 4: 374-381.
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66:   Fu, A.K.Y., F.C. Ip, K.O. Lai, K.W.K. Tsim and N.Y. Ip, 1997. Muscle-derived neurotrophin-3 increases the aggregation of acetylcholine receptors in neuron-muscle co-cultures. Neuroreport, 8: 3895-3900.
PubMed  |  
67:   Fu, H., W. Li, J. Luo, N.T. Lee and M. Li et al., 2008. Promising anti-Alzheimer's dimer bis(7)-tacrine reduces beta-amyloid generation by directly inhibiting BACE-1 activity. Biochem.Biophys. Res. Commun., 366: 631-636.
CrossRef  |  PubMed  |  Direct Link  |  
68:   Fu, H., W. Li, Y. Lao, J. Luo and N.T. Lee et al., 2006. Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels. J. Neurochem., 98: 1400-1410.
PubMed  |  
69:   Fu, H., Y. Liu, Y. Lao, W. Liu and C. Chen et al., 2007. Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of Bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons. J. Proteome Res., 6: 2435-2446.
PubMed  |  
70:   Gao, Q.T., G.X. Chou, T.T.X. Dong, J. Li, R. Duan, A.W.H. Cheung and K.W.K. Tsim, 2007. Identification and quality control of Radix et Rhizoma Gentianae by chemical fingerprint: evaluation of gentiopicrin from different cultivated regions in China. Asian. J. Tradition. Medi., 4: 121-129.
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71:   Gao, Q.T., J. Li, , G.K. Chu, R. Duan and A.W. Cheung et al., 2007. Danggui buxue tang--a Chinese herbal decoction activates the phosphorylations of extracellular signal-regulated kinase and estrogen receptor alpha in cultured MCF-7 cells. FEBS Lett., 581: 233-240.
PubMed  |  Direct Link  |  
72:   Gao, Q.T., J. Li, J.K.Cheung, J. Duan and A. Ding et al ., 2007. Verification of the formulation and efficacy of Danggui Buxue Tang (a decoction of Radix Astragali and ): an exemplifying systematic approach to revealing the complexity of Chinese herbal medicine formulae. Chinese Medi. J., 2: 12-22.
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73:   Gao, Q.T., J.K.H. Cheung, J. Li, G.K.Y. Chu and R. Duan et al., 2006. A Chinese herbal decoction, danggui buxe tang, prepared from radix astragali and radix angelicae sinensis stimulates the immune responses. Planta Med., 72: 1227-1231.
CrossRef  |  PubMed  |  Direct Link  |  
74:   Gao, Q.T., J.K.H. Cheung, J. Li, Z.Y. Jiang and G.K.Y. Chu et al., 2007. A Chinese herbal decoction Danggui Buxue Tang stimulates the release of cytokines in cultured T-lymphocytes: a signal triggered by extracellular signal-regulated kinase. FEBS. Lett., 581: 5087-5093.
CrossRef  |  PubMed  |  
75:   Gao, Q.T., J.K.H. Cheung, R.C.Y. Choi, A.W.H., Cheung and J. Li, et al., 2008. A Chinese herbal decoction prepared from Radix Astragali and Radix Angelicae Sinensis induces the expression of erythropoietin in cultured Hep3B cells. Planta. Med., 74: 392-395.
CrossRef  |  PubMed  |  Direct Link  |  
76:   Guo, A.J., R.C. Choi, A.W. Cheung, V.P. Chen and S.L. Xu et al., 2011. Baicalin a flavone, induces the differentiation of cultured osteoblasts an action via the Wnt/β-catenin signaling pathway. J. Biol. Chem., 286: 27882-27893.
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77:   Guo, A.J.Y., H.Q. Xie, R.C.Y. Choi, K.Y.Z. Zheng and C.W.C. Bi et al., 2010. Galangin, a flavonol derived from Rhizoma Alpiniae Officinarum, inhibits acetylcholinesterase activity in vitro. Chem. Biol. Interactions, 187: 246-248.
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78:   Guo, A.J.Y., R.C.Y. Choi, A.W.H. Cheung, J. Li and I.X.Y. Chen et al., 2009. Stimulation of Apolipoprotein A-IV expression in Caco-2/TC7 enterocytes and reduction of triglyceride formation in 3T3-L1 adipocytes by traditional Chinese medicines: Potential in developing anti-obesity drugs. Chin. Med. J., 4: 5-10.
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79:   Guo, A.J.Y., R.C.Y. Choi, Y.Z. Zheng, V.P. Chen and T.T.X. Dong et al., 2012. Kaempferol induces osteoblastic differentiation via estrogen receptor signaling in cultured osteoblasts: A flavonoid deriving from herbal for against post-menopausal osteoporosis. Chin. Med. J., 7: 10-15.
80:   Huang, W.Z., T.T.X. Dong, H.Y. Qi, Z.Q. Lu and K.W.K. Tsim, 2005. Identification of Stellaria medica by PCR. J. Chin. Pharm. Sci., 14: 144-148.
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81:   Ip, F.C., A.K. Fu, K.W. Tsim and N.Y. Ip, 1996. Differential expression of ciliary neurotrophic factor receptor in skeletal muscle of chick and rat after nerve injury. J. Neurochem., 67: 1607-1612.
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82:   Ip, F.C., A.K. Fu, K.W. Tsim and NY. Ip, 1995. Cloning of the α component of the chick ciliary neurotrophic factor receptor: Developmental expression and down‐regulation in denervated skeletal. J. Neurochem., 65: 2393-2400.
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83:   Ip, P.S., K.W.K. Tsim, K. Chan and R. Bauer, 2012. Application of complementary and alternative medicine on neurodegenerative disorders: Current status and future prospects. Evid. Based Complement. Alternat. Med., Vol.2012. 10.1155/2012/930908.
CrossRef  |  PubMed  |  
84:   Ji, Z.N., T.T. Dong, W.C. Ye, R.C.Y. Choi, C.K. Lo and K.W. Tsim, 2006. Ginsenoside Re attenuate β-amyloid and serum-free induced neurotoxicity in PC12 cells. J. Ethnopharmacol., 107: 48-52.
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85:   Ji, Z.N., W.Y. Zhao, G.R. Liao, R.C.Y. Choi, C.K. Lo, T.T.X. Dong and K.W.K. Tsim, 2006. In vitro estrogenic activity of formononetin by two bioassay systems. Gynecol. Endocrinol., 22: 578-584.
PubMed  |  
86:   Jiang, J.X., R.C. Choi, N.L. Siow, H.H. Lee, D.C. Wan and K.W. Tsim, 2003. Muscle induces neuronal expression of acetylcholinesterase in neuron-muscle co-culture transcriptional regulation mediated by cAMP-dependent signaling. J. Biol. Chem., 278: 45435-45444.
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87:   Kong, L., R.C. Choi, H.Q. Xie, X. Wang and G. Peng et al., 2011. Expression of the IgSF protein Kirre in the rat central nervous system. Life Sci., 88: 590-597.
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88:   Kong, L.W., R.C.Y. Choi, K.W.K. Tsim, N. Jing, D.K. Nakayama and Z. Wang, 2013. Distribution and expression of Kirre, an IgSF molecule, during postnatal development of rat cerebellum. Neurosci. Lett., 543: 22-26.
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89:   Kuijun, Z., Z. Li, X. Chen, T. Dong and K.W. Tsim, 2009. Rationality of mixed preparation of traditional herbal decoction: From the perspective of Danggui Buxue tang. World Sci. Technol.-Modernization Traditional Chin. Med. Mater. Med., 11: 294-298.
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90:   Lao, S.C., S.P. Li, K.K.W. Kan, P. Li and J.B. Wan et al., 2004. Identification and quantification of 13 components in Angelica sinensis (Danggui) by gas chromatography-mass spectrometry coupled with pressurized liquid extraction. Analytica Chim. Acta, 526: 131-137.
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91:   Lau, F.T.C., R.C.Y. Choi, H.Q. Xie, K.W. Leung, and V.P. Chen et al ., 2008. Myocyte enhancer factor 2 mediates the muscular activity-induced expression of acetylcholinesterase associated collagen ColQ in cultured myotubes: a signaling cascade in driving the differential expression of ColQ in muscles. Mol. Cell Neurosci., 39: 429-438.
92:   Lee, H.H., R.C. Choi, A.K. Ting, N.L. Siow, J.X. Jiang, J. Massoulie and K.W. Tsim, 2004. Transcriptional regulation of acetylcholinesterase-associated collagen ColQ: Differential expression in fast and slow twitch muscle fibers is driven by distinct promoters. J. Biol. Chem., 279: 27098-27107.
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93:   Leung, K.W., H.Q. Xie, V.P. Chen, G.K.Y. Chu, R.C.Y. Choi and K.W.K. Tsim, 2009. Restricted localization of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase at the neuromuscular junctions: Contribution and expression from motor neurons. FEBS J., 276: 3031-3042.
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94:   Li, C.Y., D.T. Lau, T.T. Dong, J. Zhang and R.C. Choi et al., 2013. Dual-indexes evaluation of character changes for Panax ginseng C. A. Mey stored in different conditions. J. Agric. Food Chem., 61: 6568-6573.
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95:   Li, H.Y., L.L. Zhang, C.M. Zhang, X.P. Liu, Y.L. Liu, K.W.K. Tsim and C. Hu, 2008. Synthesis and anti-platelet aggregative activity of the mannich bases of 4-chromanones and 4-chromones. Fine Chem. Intermed., 38: 13-17.
96:   Li, J., A.W.H. Cheung, C.W.C. Bi, R. Duan and K.Y.Z. Zheng et al., 2010. Quality evaluation of Radix Glehniae (Glehnia littoralis) by HPLC-DAD: chromatographic fingerprinting and quantitative analysis of the herbs from different regions of China. Asian J. Traditional Med., 5: 40-48.
Direct Link  |  
97:   Li, J., W.Z.M. Li, W. Huang, A.W.H. Cheung and W.C. Bi et al., 2009. Quality evaluation of Rhizoma Belamcandae (Belamcanda chinensis (L.) DC.) by using high-performance liquid chromatography coupled with diode array detector and mass spectrometry. J. Chromatography A, 1216: 2071-2078.
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98:   Li, J., X. Dong, Y. Jiang, Q. Gao, Y. Jiang and A.W.H. Cheung et al., 2007. Simultaneous determination of phenols in Radix Polygalae by high performance liquid chromatography: quality assurance of the herbs from different cultivated regions and seasons. J. Sep. Sci., 30: 2583-2589.
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99:   Li, J., X.B. Dong, Y. Jiang, T.T.X. Dong, P.F. Tu and K.W.K.Tsim, 2007. HPLC determination of total saponins in Radix Polygalae. Chin. J. Pharm. Anal., 27: 1329-1332.
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100:   Li, J., Z.M. Li, W. Huang, R. Duan and W.C. Bi et al., 2009. Study on the fingerprint and quality of Herba Audrograghidis from different habitats. Mod. Chin. Med., 11: 21-24.
101:   Li, S.P. and K.W. Tsim, 2006. Quality Control of Cordyceps Sinensis, a Valued Traditional Chinese Medicine. In: Recent Progress in Medicinal Plants, Anil, K., J.N. Sharma and V.K.S. Govil (Eds.). Studium Press, USA.
102:   Li, S.P., F.Q. Yang and K.W. Tsim, 2006. Quality control of Cordyceps sinensis, a valued traditional Chinese medicine. J. Pharm. Biomed Anal., 41: 1571-1584.
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103:   Li, S.P., G.H. Zhang, Q. Zeng, Z.G. Huang, Y.T. Wang, T.T.X. Dong and K.W.K. Tsim, 2006. Hypoglycemic activity of polysaccharide, with antioxidation, isolated from cultured Cordyceps mycelia. Phytomedicine, 13: 428-433.
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104:   Li, S.P., H. Ji, P. Li, T.T.X. Dong, K.W.K. Tsim and W.Q. Li, 2001. Advance of anti-tumor for Cordyceps sinensis. Chin. Traditional Herbal Drugs, 32: 373-375.
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105:   Li, S.P., K.J. Zhao, Z.N. Ji, Z.H. Song and T.T. Dong et al., 2003. A polysaccharide isolated fromCordyceps sinensis a traditional Chinese medicine, protects PC12 cells against hydrogen peroxide-induced injury. Life Sci., 73: 2503-2513.
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106:   Li, S.P., P. Li, C.M. Lai, Y.X. Gong and K.K. Kan et al., 2004. Simultaneous determination of ergosterol, nucleosides and their bases from natural and cultured Cordyceps by pressurised liquid extraction and high-performance liquid chromatography. J. Chromatogr. A, 1036: 239-243.
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107:   Li, S.P., P. Li, H. Ji, P. Zhang, T.T.X. Dong and K.W.K. Tsim, 2001. The nucleotides contents and their variation in natural Cordyceps sinensis and cultured Cordyceps mycelia. Acta Pharma Sinica, 36: 436-439.
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108:   Li, S.P., P. Li, T.T. Dong and K.W. Tsim, 2001. Determination of nucleosides in natural Cordyceps sinensis and cultured Cordyceps mycelia by capillary electrophoresis. Electrophoresis, 22: 144-150.
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109:   Li, S.P., P. Li, T.T.X. Dong and K.W.K. Tsim, 2000. Implication and prospect of bio-chip on the identification of traditional Chinese medicine. World Sci. Technol. Modernization Traditional Chin. Med., 2: 15-18.
110:   Li, S.P., P. Li, T.T.X. Dong and K.W.K. Tsim, 2001. Anti-oxidation activity of different types of naturalCordyceps sinensis and culturedCordyceps mycelia. Phytomedicine, 8: 207-212.
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111:   Li, S.P., Z.H. Song, T.T.X. Dong, C.K. Lo, S.Q. Zhu and K.W.K. Tsim, 2004. Distinction of water-soluble constituents between natural and cultured Cordyceps by capillary electrophoresis. Phytomedicine, 11: 684-690.
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112:   Li, S.P., Z.R. Su, T.T.X. Dong and K.W.K. Tsim, 2002. The fruiting body and its caterpillar host of Cordyceps sinensis show close resemblance in main constituents and anti-oxidation activity. Phytomedicine, 9: 319-324.
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113:   Li, W., N.T. Lee, H. Fu, K.K. Kan and Y. Pang et al., 2006. Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine. NeuroReport, 17: 471-474.
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114:   Li, W.M., J. Xue, C.Y. Niu, H.J. Fu and C.S.C. Lam et al., 2007. Synergistic neuroprotection by bis-(7)-tacrine via concurrent blockade of N-methyl-D-asparatate receptors and neuronal nitric oxide synthase. Mol. Pharmacol., 71: 1258-1267.
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115:   Li, W.M., R.B. Pi, H.N. Chan, H.J. Fu and N.T.K. Lee et al., 2005. Novel dimeric AChE inhibitor bis(7)-tacrine, but not Donepezil, prevents glutamate-induced neuronal apoptosis by blocking NMDA receptors. J. Biol. Chem., 280: 18179-18188.
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116:   Li, W.Z.M., J. Li, C.W.C. Bi, A.W.H. Cheung and W. Huang et al., 2009. Can rhizoma chuanxiong replace radix angelica sinensis in a traditional chinese herbal decoction-danggui buxue tang? Planta Med., 75: 602-606.
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117:   Lin, H.Q., R. Choi, K.L. Chan, D. Ip, K.W.K. Tsim and D.C. Wan, 2010. Differential gene expression profiling on the muscle of acetylcholinesterase knockout mice: A preliminary analysis. Chem. Biol. Interactions, 187: 120-123.
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118:   Ling, K.K., N.L. Siow, R.C. Choi, A.K. Ting, L.W. Kong and K.W. Tsim, 2004. ATP Potentiates agrin-induced achr aggregation in cultured myotubes: Activation of rhoa in p2y1 nucleotide receptor signaling at vertebrate neuromuscular junctions. J. Biol. Chem., 279: 31081-31088.
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119:   Ling, K.K.Y., N.L. Siow, R.C.Y. Choi and K.W.K. Tsim, 2005. ATP potentiates the formation of AChR aggregate in the co-culture of NG108-15 cells with C2C12 myotubes. FEBS Lett., 579: 2469-2474.
PubMed  |  
120:   Liu, H., K.W. Tsim, G.X. Chou, J.M. Wang, L.L. Ji and Z.T. Wang, 2011. Phenolic compounds from the rhizomes of Dioscorea bulbifera. Chem. Biodivers., 8: 2110-2116.
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121:   Liu, R.X., T.T. Zhou, T.T.X. Dong, K.W.K. Tsim and K.S. Bi, 2003. Establishment of HPLC fingerprint analysis for the quality assessment of Angelica sinensis. Chin Pharm. J., 38: 757-760.
Direct Link  |  
122:   Liu, W.J., D.K. Cai, L.F. Liu, P. Lai, T.X. Dong, K.W.K. Tsim and Z.R. Su, 2009. HPLC determination of astragaloside IV in Danggui Buxue tablets. Chin. J. Pharm. Anal., 29: 1553-1555.
123:   Luk, W.K.W., V.P. Chen, R.C.Y. Choi and K.W.K. Tsim, 2012. N-linked glycosylation of dimeric acetylcholinesterase in erythrocytes is essential for enzyme maturation and membrane targeting. FEBS J., 279: 3229-3239.
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124:   Ma, X.Q., D.Y. Zhu, S.P. Li, T.T.X. Dong and K.W K. Tsim, 2001. Authentic identification of stigma Croci (stigma of Crocus sativus) from its adulterants by molecular genetic analysis. Planta Med., 67: 183-186.
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125:   Ma, X.Q., J.A. Duan, D.Y. Zhu, T.T.X. Dong and K.W.K. Tsim, 2000. Species identification of Radix Astragali (Huangqi) by DNA sequence of its 5S-rRNA spacer domain. Phytochemistry, 54: 363-368.
126:   Ma, X.Q., J.A. Duan, D.Y. Zhu, T.X. Dong and K.W.K. Tsim, 2000. Chemical comparison of Astragali Radix (Huangqi) from different regions of China. Nat. Med., 54: 213-218.
Direct Link  |  
127:   Ma, X.Q., Q. Shi, J.A. Duan, T.T.X. Dong and K.W.K. Tsim, 2002. Chemical analysis of Radix Astragali (Huangqi) in China: A comparison with its adulterants and seasonal variations. J. Agric. Food Chem. 50: 4861-4866.
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128:   Ma, X.Q., T.T.X. Dong and K.W.K. Tsim, 2001. Determination of water-soluble constituents from the drug materials of ''Honghua''. J. Pharmaceutical Practice, 18: 310-311.
129:   Ma, X.Q., TT.X. Dong and K.W.K. Tsim, 2000. Active compounds determination of Crocus sativus and its related species by HPLC. J. Pharm Practice, 42: 213-2172.
130:   Maiwulanjiang, M., K.Y. Zhu, J.P. Chen, A. Miernisha and S.L. Xu et al., 2013. Song Bu Li decoction, a traditional Uyghur medicine, protects cell death by regulation of oxidative stress and differentiation in cultured PC 12 cells. Evidence Based Complementary Alternative Med., Vol. 2013. 10.1155/2013/687958.
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131:   Mak, D.H.F., P.Y. Chiu, T.T. Dong, K.W. Tsim and K.M. Ko, 2006. Dang-Gui Buxue Tang produces a more potent cardioprotective effects than its component herb extracts and enhances glutathione status in rat heart mitochondria and erythrocytes. Phytotherapy Res., 20: 561-567.
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132:   Mok, K.W., K.W. Leung, H.Q. Xie, A.J.Y. Guo and V.P. Chen et al., 2009. A new variant of proline-rich membrane anchor (PRiMA) of acetylcholinesterase in chicken: expression in different muscle fiber types. Neurosci. Lett., 461: 202-206.
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133:   Ng, K.L., C.C. Lam, Z.B. Fu, Y.F. Han, K.W.K. Tsim and W.K.R. Wong, 2007. Cloning and characterization of the yjeA gene, encoding a novel deoxyribonuclease, from Bacillus subtilis. J. Biochem., 142: 647-654.
PubMed  |  
134:   Ng, Y.P., S. Pun, J.F. Yang, N.Y. Ip and K.W.K. Tsim, 1997. Chick muscle expresses various ARIA isoforms: Regulation during development, denervation and regeneration. Mol. Cell. Neurosci., 9: 132-143.
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135:   Ng, Y.P., Z.K. Wu, H. Wise, K.W.K. Tsim, Y.H. Wong and N.Y. Ip, 2009. Differential and synergistic effect of nerve growth factor and cAMP on the regulation of early response genes during neuronal differentiation. Neurosignals, 17: 111-120.
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136:   Pak, R.C., K.W. Tsim and C.H. Cheng, 1985. The role of neonatal and pubertal gonadal hormones in regulating the sex dependence of the hepatic microsomal testosterone 5-reductase activity in the rat. J. Endocrinol., 106: 71-79.
PubMed  |  
137:   Pak, R.C.K., K.W.K. Tsim and C.H.K. Cheng, 1984. Pubertal gonadal hormones in modulating the testosterone dependency of hepatic aryl hydrocarbon hydroxylase in female rats. Pharmacology, 29: 121-127.
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138:   Pun, S. and K.W.K. Tsim, 1995. Truncated form of pro-acetylcholine receptor-inducing activity (ARIA) induces AChR alpha-subunit but not AChE transcripts in cultured chick myotubes. Neurosci Lett., 198: 107-110.
PubMed  |  
139:   Pun, S. and K.W.K. Tsim, 1997. Anti-sense agrin cDNA transfection blocks neuroblastoma cell-induced acetylcholine receptor aggregates when co-cultured with myotubes. Mol. Cell. Neurosci., 10: 87-99.
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140:   Pun, S., J.F. Yang, Y.P. Ng and K.W. Tsim, 1997. NG108-15 cells express neuregulin that induces AChR α-subunit synthesis in cultured myotubes. FEBS Lett., 418: 275-281.
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141:   Pun, S., Y.P. Ng, J.F. Yang, N.Y. Ip and K.W. Tsim, 1997. Agrin‐deficient myotube retains its acetylcholine receptor aggregation ability when challenged with agrin. J. Neurochem., 69: 2555-2563.
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142:   Randall, W.R., K.W. Tsim, J. Lai and E.A. Barnard, 1987. Monoclonal antibodies against chicken brain acetylcholinesterase. Eur. J. Biochem., 164: 95-102.
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143:   Reiss, Y., S. Kroger, J. Grassi, K.W. Tsim, E. Willbold and P.G. Layer 1996. Extracellular and asymmetric forms of acetylcholinesterase are expressed on cholinergic and noncholinergic terminal neuropil of the developing chick retina. Cell Tiss. Res., 286: 13-22.
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144:   Ruegg, M.A., K.W.K. Tsim, S.E. Horton, S. Kroger and G. Escher et al., 1992. The agrin gene codes for a family of basal lamina proteins that differ in function and distribution. Neuron, 8: 691-699.
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145:   Siow, N.L., R.C. Choi, A.W. Cheng, J.X. Jiang, D.C. Wan, S.Q. Zhu and K.W. Tsim, 2002. A cyclic AMP-dependent pathway regulates the expression of acetylcholinesterase during myogenic differentiation of C2C12 cells. J. Biol. Chem., 277: 36129-36136.
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146:   Siow, N.L., R.C. Choi, H.Q. Xie, L.W. Kong and G.K. Chu et al., 2010. ATP induces synaptic gene expressions in cortical neurons: transduction and transcription control via P2Y1 receptors. Mol. Pharmacol., 78: 1059-1071.
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147:   So, K.L., S. Pun, D.C.C. Wan and K.W.K. Tsim, 1996. Cerebellar granule cells express a specific isoform of agrin that lacks the acetylcholine receptor aggregating activity. FEBS Lett., 379: 63-68.
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148:   Song, Z.H., C.K. Lo, T.T.X. Dong, O.T.W. Li and Z.N. Ji et al., 2004. Chemical and biological assessment of a traditional Chinese herbal decoction prepared from Radix Astragali and Radix Angelica Sinensis: Orthogonal array design to optimize the extraction of chemical constituents. Planta Med., 70: 1222-1227.
PubMed  |  
149:   Stadlin, A., H.L. Choi, K.W.K. Tsim and D. Tsang, 1995. Prenatal cocaine exposure revealed minimal postnatal changes in rat striatal dopamine D2 receptor sites and mRNA levels in the offspring. Mol. Neurobiol., 11: 67-76.
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150:   Su, J.Y., Q.F. Xie, W.J. Liu, P. Lai and D.D. Liu et al., 2013. Peri-menopause amelioration of a TCM recipe composed of Radix Astragali, Radix Angelicae Sinensis and Folium Epimedii: An in vivo study on natural aging rat model. Evidence Based Complementary Alternative Med. http://www.hindawi.com/journals/ecam/aip/747240/.
151:   Su, Z.R., Chen, X.L. Shen, T.T.X. Dong and K.W.K. Tsim, 2002. Comments on the change of drug nature and innovation of Chinese patent drugs in the preparing process. Traditional Chin. Drug Res. Clin. Pharmacol., 13: 1-4.
152:   Su, Z.R., L. Liu, T.T.X. Dong, K.W.K. Tsim, 2002. The heat-induced degradation of magnolol and honokiol in supercritical fluid CO2 extraction from Magnolia bark. Acta Pharma. Sinica, 37: 870-875.
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153:   Su, Z.R., T.T.X. Dong, K.M. Chan and K.W.K. Tsim, 2001. The separation and reconstitution of active ingredients of TCM. Chin. Traditional Patent Med., 23: 615-616.
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154:   Su, Z.R., X.D. Huang, T.T.X. Dong and K.W.K. Tsim, 2002. The development of TCM formula and patent drugs. Traditional Chin. Drug Res. Clin. Pharmacol., 13: 343-345.
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155:   Ting, A.K.L., S.L. Siow, L.W. Kong and K.W.K. Tsim, 2005. Transcriptional regulation of acetylcholinesterase-associated collagen ColQ in fast-and slow-twitch muscle fibers. Chem. Biol. Interact, 157-158: 63-70.
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156:   Tsim, K.W. and E.A. Barnard, 2002. The signaling pathways mediated by P2Y nucleotide receptors in the formation and maintenance of the skeletal neuromuscular junction. Neurosignals, 11: 58-64.
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157:   Tsim, K.W., I. Greenberg, M. Rimer, W.R. Randall and M.M. Salpeter, 1992. Transcripts for the acetylcholine receptor and acetylcholine esterase show distribution differences in cultured chick muscle cells. J. Cell Biol., 118: 1201-1212.
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158:   Tsim, K.W., M.A. Ruegg, G. Escher, S. Kroger and U.J. McMahan, 1992. cDNA that encodes active agrin. Neuron, 8: 677-690.
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159:   Tsim, K.W., R.C. Choi, T.T. Dong and D.C. Wan, 1997. A Globular, not asymmetric, form of acetylcholinesterase is expressed in chick motor neurons: Down‐regulation toward maturity and after denervation. J. Neurochem., 68: 479-487.
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160:   Tsim, K.W., W.R. Randall and E.A. Barnard, 1988. An asymmetric form of muscle acetylcholinesterase contains three subunit types and two enzymic activities in one molecule. Proc. Natl. Acad. Sci., 85: 1262-1266.
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161:   Tsim, K.W., W.R. Randall and E.A. Barnard, 1988. Identification of a 17 S asymmetric butyrylcholinesterase in chick muscle by monoclonal antibodies. Neurosci Lett., 86: 245-249.
PubMed  |  
162:   Tsim, K.W., W.R. Randall and E.A. Barnard, 1988. Monoclonal antibodies specific for the different subunits of asymmetric acetylcholinesterase from chick muscle. J. Neurochem., 51: 95-104.
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163:   Tsim, K.W., W.R. Randall and E.A. Barnard, 1988. Synaptic acetylcholinesterase of chicken muscle changes during development from a hybrid to a homogeneous enzyme. EMBO J., 7: 2451-2456.
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164:   Tsim, K.W.K,. R.C.Y. Choi, H.Q. Xie, Z.T.T. Zhu and K.W. Leung et al., 2008. Transcriptional control of different subunits of AChE in muscles: Signaling triggered by the motor nerve-derived factors. Chem. Biol. Interact., 175: 58-63.
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165:   Tsim, K.W.K. and C.H. Cheng, 1984. Evidence for the involvement of essential sulphydryl group in rat hepatic lactogenic receptor but not in somatogenic receptor. Mol. Cell Endocrinol., 38: 61-66.
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166:   Tsim, K.W.K. and H. Soreq, 2012. Acetylcholinesterase: Old questions and new developments. Front. Mol. Neurosci. 10.3389/fnmol.2012.00101.
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167:   Tsim, K.W.K., 2005. Danggui Buxue Tang (DBT, Chinese Angelica decoction): A sample trial in TCM standardization. Asia-Pacific Biotech News (APBN), 8: 1316-1321.
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168:   Tsim, K.W.K., H.Q. Xie, A.K. Ting, N.L. Siow, K.K. Ling and L.W. Kong, 2006. Transcriptional control of different acetylcholinesterase subunits in formation and maintenance of vertebrate neuromuscular junctions. J. Mol. Neurosci., 30: 189-192.
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169:   Tsim, K.W.K., K.W. Leung, K.W. Mok, V.P. Chen and K.Y. Zhu et al., 2010. Expression and localization of PRiMA-linked globular form acetylcholinesterase in vertebrate neuromuscular junctions. J. Mol. Neurosci., 40: 40-46.
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170:   Tsim, K.W.K., R.C. Pak and C.H. Cheng, 1985. Prolactin receptor in rat liver: Sex difference in estrogenic stimulation and imprinting of the responsiveness to estrogen by neonatal androgen in male rats. Mol. Cell Endocrinol., 40: 99-105.
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171:   Tsim, K.W.K., R.C.Y. Choi, N.L. Siow, A.W.M. Cheng and K.K.Y. Ling et al., 2003. ATP induces post-synaptic gene expressions in vertebrate skeletal neuromuscular junction. Brain Cell Biol., 32: 603-617.
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172:   Tsim, K.W.K., R.C.Y. Choi, N.L. Siow, A.W.M. Cheng and K.K.Y. Ling et al., 2004. The Role of P2Y1 Nucleotide Receptors in the Formation and Maintenance of the Skeletal Neuromuscular Junctions. In: Cholinergic Mechanisms, Fisher, A. and H. Soreq (Eds.). Martin Dunitz, London.
173:   Tung, E.K., R.C. Choi, N.L. Siow, J.X. Jiang and K.K. Ling et al., 2004. P2Y2 receptor activation regulates the expression of acetylcholinesterase and acetylcholine receptor genes at vertebrate neuromuscular junctions. Mol. Pharmacol., 66: 794-806.
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174:   Wan, D.C., L.K. Law, D. Ip, W.T. Cheung, W.K. Ho, K.W. Tsim and C.P. Pang, 1999. Lack of allelic association of dopamine D4 receptor gene polymorphisms with Parkinson's disease in a Chinese population. Movement Disorders, 14: 225-229.
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175:   Wan, D.C., R.C. Choi, N.L. Siow and K.W. Tsim, 2000. The promoter of human acetylcholinesterase is activated by a cyclic adenosine 3', 5'-monophosphate-dependent pathway in cultured NG108-15 neuroblastoma cells. Neurosci. Lett., 288: 81-85.
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176:   Wan, D.C., S.K. Luk, K.W. Tsim and W.T. Cheung, 1997. Expression and localization of endothelin converting enzyme in rat vas deferens. Life Sci., 60: 1605-1612.
PubMed  |  
177:   Wan, D.C., X. Zhang, N.L. Siow, H.Q. Xie and K.W. Tsim, 2006. Chick acetylcholinesterase promoter regulation. J. Mol. Neurosci., 30: 33-34.
PubMed  |  
178:   Wan, D.C., Y.P. Ng, R.C. Choi, P.W. Cheung, T.T. Dong and K.W. Tsim, 1997. Denervation decreases the ipsilateral expression of AChE in chick lumbaric motor neurons. Neurosci. Lett., 232: 83-86.
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179:   Wan, J.B., P. Li, S.P. Li, Y.T. Wang, T.T. Dong and K.W.K. Tsim, 2006. Simultaneous determination of 11 saponins in Panax notoginseng using HPLC-ELSD and pressurized liquid extraction. J. Separation Sci., 29: 2190-2196.
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180:   Wang, T., R.C. Choi, J. Li, J. Li and C.W. Bi, 2010. Antihyperlipidemic effect of protodioscin, an active ingredient isolated from the rhizomes of Dioscorea nipponica. Planta Med., 76: 1642-1646.
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181:   Wang, T.J., R.C. Choi, J. Li, C.W. Bi and W. Ran et al., 2012. Trillin, a compound isolated from the rhizomes of Dioscorea nipponica, exerts the protection effects against hyperlipidemia and oxidation. J. Ethnopharmacol, 139: 214-220.
182:   Wang, Y., K. Zhou, L. Xu, T.T. Dong and K.W. Tsim, 2000. Authentication of an animal crude drug, Zaocys, by diagnostic PCR. Biol. Pharm. Bull., 23: 585-588.
PubMed  |  
183:   Wang, Y.Q., K.Y. Zhou, L.S. Xu and K.W.K. Tsim, 1999. The present situation and application of the molecular identification of Chinese medicinal materials. Prog Pharmaceutical. Sci., 23: 193-198.
184:   Weetman, A.P., C.K. Tse, W.R. Randall, K.W. Tsim and E.A. Barnard, 1988. Acetylcholinesterase antibodies and thyroid autoimmunity. Clin. Exp. Immunol., 71: 96-99.
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185:   Wei, J.F., K.J. Zhao, R. Duan, T.T.X. Dong, K.W.K. Tsim, 2008. Pharmacognostic identification of herba drymariae. Res. Pract. Chin. Medi., 21: 17-18.
186:   Wen, H.M., X.H. Chen, T.X. Dong, K.W. Tsim and K.S. Bi, 2006. Determination of heavy metals in four traditional Chinese medicines by ICP-MS. China J. Chin. Mater. Med., 31: 1314-1317.
PubMed  |  
187:   Wu, P.K., W. Tai, R.C. Choi, K.W. Tsim and H. Zhou et al., 2011. Chemical and DNA authentication of taste variants of Gynostemma pentaphyllum herbal tea. Food Chem., 128: 70-80.
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188:   Wu, X.M., H. Dai, L.X. Huang, X.M. Gao, K.W. Tsim and P.F. Tu, 2006. A fructan, from Radix Ophiopogonis, stimulates the proliferation of cultured lymphocytes: Structural and functional analyses. J. Nat. Prod., 69: 1257-1260.
PubMed  |  
189:   Wu, X.M., X.M. Gao, K.W.K. Tsim and P.F. Tu, 2005. An arabinogalactan isolated from the stems of Cistanche deserticola induces the proliferation of cultured lymphocytes. Int. J. Biol. Macromolecules, 37: 278-282.
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190:   Xia, Q., K.J. Zhao, Z.G. Huang, P. Zhang, T.T.X. Dong, S.P. Li and K.W.K. Tsim, 2005. Molecular genetic and chemical assessment of Rhizoma Curcumae in China. J. Agric. Food Chem., 53: 6019-6026.
PubMed  |  
191:   Xia, Q., T.X. Dong, K.W. Tsim, K.W. Leung and S.P. Li, 2006. Inhibition effect of curdione on platelet aggregation induced by ADP in rabbits. Chin. Pharmacol. Bull., 22: 1151-1152.
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192:   Xia, Q., T.X. Dong, K.W. Tsim, Z.G. Huang and P. Zhang, 2006. HPLC-ELSD determination of platycodin E in Radix Platycodonis of different sources. China J. Pharm. Anal., 26: 637-639.
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193:   Xie, H.Q, K.W. Leung, V.P. Chen, F.T.C. Lau, L.S. Liu, R.C.Y. Choi, K.W.K. Tsim, 2008. The promoter activity of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase in muscle: Suppressive roles of myogenesis and innervating nerve. Chem. Biol. Interact., 175: 79-82.
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194:   Xie, H.Q., D. Liang, W.K.W. Leung, V.P. Chen and K.Y. Zhu et al., 2010. Targeting acetylcholinesterase to membrane rafts: A function mediated by the proline-rich membrane anchor (PRiMA) in neurons. J. Biol. Chem., 285: 11537-11546.
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195:   Xie, H.Q., K.W. Leung, V.P. Chen, G.K.L. Chan and S.L. Xu et al., 2010. PRiMA directs a restricted localization of tetrameric AChE at synapses. Chem. Biol. Interactions, 187: 78-83.
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196:   Xie, H.Q., R.C.Y. Choi, K.W. Leung, N.L. Siow and L.W. Kong ert al., 2007. Regulation of a transcript-encoding the proline rich membrane anchor (PRiMA) of globular muscle acetylcholinesterase: The suppressive roles of myogenesis and innervating nerves. J. Biol. Chem., 282: 11765-11775.
PubMed  |  
197:   Xie, H.Q., R.C.Y. Choi, K.W. Leung, V.P. Chen, G.K.Y. Chu and K.W.K. Tsim, 2009. Transcriptional regulation of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase in neuron: An inductive effect of neuron differentiation. Brain Res., 1265: 13-23.
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198:   Xie, Q.F., J.H. Xie, T.T. Dong, J.Y. Su and D.K. Cai et al., 2012. Effect of a derived herbal recipe from an ancient Chinese formula, Danggui Buxue Tang, on ovariectomized rats. J. Ethnopharmacol., 144: 567-575.
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199:   Xu, H., Z.R. Su, W. Huang, R.C.Y. Choi and Y.Z. Zheng et al., 2012. Er Zhi Wan an ancient herbal decoction for woman menopausal syndrome, activates the estrogenic response in cultured MCF-7 cells: An evaluation of compatibility in defining the optimized preparation method. J. Ethnopharmacol, 143: 109-115.
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200:   Xu, S.L., C.W.C. Bi, R.C.Y. Choi, K.Y. Zhu, A. Miernisha, T.T.X. Dong and K.W.K. Tsim, 2013. Flavonoids induce the synthesis and secretion of neurotrophic factors in cultured rat astrocytes: A signaling response mediated by estrogen receptor. Evidence-Based Complementary Alternative Med., Vol. 2013. 10.1155/2013/127075.
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201:   Xu, S.L., K.Y. Zhu, C.W.C. Bi, R.C.Y. Choi and M. Abudureyimu et al., 2013. Flavonoids induce the expression of synaptic proteins, synaptotagmin and post-synaptic density protein-95, in cultured rat cortical neuron. Planta Med. 10.1055/s-0033-1351023.
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202:   Xu, S.L., R.C. Choi, K.Y. Zhu, K.W. Leung and A.J. Guo et al., 2012. Isorhamnetin a flavonol aglycone from Ginkgo biloba L., induces neuronal differentiation of cultured pc12 cells: Potentiating the effect of nerve growth factor. Evid Based Complement Alternat. Med., 10.1155/2012/278273.
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203:   Yang, F.Q., S.P. Li, Y. Chen, Q.Q. Liu, Y.T. Wang, T.T.X. Dong and K.W.K. Tsim, 2005. Quantitative determination of curcumol, germacrone and curdione from Zedoray Rhizome by GC-MS. Chin. J. Pharm. Anal., 25: 827-830.
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204:   Yang, F.Q., S.P. Li, Y. Chen, Q.Q. Liu, Y.T. Wang, T.T.X. Dong and K.W.K. Tsim, 2005. The fingerprint of Ezhu by GC-MS. Acta Pharm. Sin., 40: 1013-1018.
PubMed  |  
205:   Yang, F.Q., S.P. Li, Y. Chen, S.C. Lao, Y.T. Wang, T.T.X. Dong and K.W.K. Tsim, 2005. Identification and quantitation of eleven sesquiterpenes in three species of Curcuma rhizomes by pressurized liquid extraction and gas chromatography-mass spectrometry. J. Pharm. Biomed Anal., 39: 552-558.
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206:   Yang, J.F., H. Zhou, R.C. Choi, N.Y. Ip, H.B. Peng and K.W. Tsim, 1999. A cysteine-rich form ofXenopus neuregulin induces the expression of acetylcholine receptors in cultured myotubes. Mol. Cell. Neurosci., 13: 415-429.
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207:   Yang, J.F., H. Zhou, S. Pun, N.Y. Ip, H.B. Peng and K.W. Tsim, 1998. Cloning of cDNAs encodingXenopus neuregulin: Expression in myotomal muscle during embryo development. Mol. Brain. Res., 58: 59-73.
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208:   Yang, J.F., Y.P. Ng, S. Pun, N.Y. Ip and K.W.K. Tsim, 1997. The EGF-like domain of chick acetylcholine receptor-inducing activity (ARIA) contains its full biological activity. FEBS Lett., 403: 163-167.
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209:   Yu, H., W.L. Zhang, X.T. Ding, K.Y.Z. Zheng, C.M. Ho, K.W.K. Tsim and Y.K. Lee, 2013. Optimizing A combination of flavonoids deriving from Astragali Radix in activating the regulatory element of erythropoietin by a feedback system control scheme. Evidence Based Complementary Alternative Med., Vol. 2013. 10.1155/2013/541436.
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210:   Yung, H.S., K.H. Lai, K.B. Chow, N.Y. Ip and K.W.K. Tsim et al., 2010. Nerve growth factor-induced differentiation of PC12 cells is accompanied by elevated adenylyl cyclase activity. Neurosignals, 18: 32-42.
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211:   Yung, L.Y., K.W. Tsim, G. Pei and Y.H. Wong, 2000. Immunoglobulin G1 Fc fragment-tagged human opioid receptor-like receptor retains the ability to inhibit cAMP accumulation. Biol. Signals, 9: 240-247.
212:   Zha, G.G., V.P. Chen, W.K.W. Luk, X.G. Zou, R.C.Y. Choi and K.W.K. Tsim, 2013. Characterization of Acetylcholinesterase in Hong Kong oyster (Crassostrea hongkongensis) from South China sea. Chem. Biol. Interact., 203: 277-281.
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213:   Zhan J.Y.X., K.Y.Z. Zheng, K.Y. Zhu, W.L. Zhang and C.W.C. Bi et al., 2013. Importance of wine-treated Angelica Sinensis Radix in Si Wu Tang, a traditional herbal formula for treating women's ailments. Planta Med., 79: 533-537.
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214:   Zhan, J.Y., K.Y. Zheng, K.Y. Zhu, C.W. Bi, W.L. Zhang and C.Y.Q. Du et al., 2011. Chemical and biological assessment of Angelicae Sinensis Radix after processing with wine: An orthogonal array design to reveal the optimized conditions. J. Agric. Food Chem., 59: 6091-6098.
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215:   Zhan, J.Y.X., Q. Fu, D. Ran, D.T.W. Lau and K.Y.Z. Zheng et al., 2011. Study on determination of indigo and indirubin contents and HPLC fingerprints of Isatidis Folium from various sources. Mod. Chin. Med., 13: 15-24.
216:   Zhan, J.Y.X., W.L. Zhang, K.Y.Z. Zheng, K.Y. Zhu and J.P. Chen et al., 2013. Chemical changes of Angelicae Sinensis Radix and Chuanxiong Rhizoma by wine treatment: Chemical profiling and marker selection by gas chromatography coupled with triple quadrupole mass spectrometry. Chin. Med. J., Vol. 8. 10.1186/1749-8546-8-12.
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217:   Zhang, W.L., K.Y.Z. Zheng, K.Y. Zhu, J.Y.X. Zhan and C.W.C. Bi et al., 2012. Chemical and biological assessment of Angelica herbal decoction: Comparison of different preparations during historical applications. Phytomedicine, 19: 1042-1048.
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218:   Zhang, W.L., K.Y.Z. Zheng, K.Y. Zhu, J.Y.X. Zhan and C.W.C. Bi et al., 2013. Chemical and biological assessment of angelica roots from different cultivated regions in a chinese herbal decoction danggui buxue tang. Evid. Based Complement. Alternat. Med., Vol. 2013. 10.1155/2013/483286.
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219:   Zhang, W.L., R.C.Y. Choi, J.Y.X. Zhang, J.P. Chen, W.K.W. Luk, P. Yao and K.W.K. Tsim, 2013. Can Hedysari Radix replace Astragali Radix in Danggui Buxue Tang, a Chinese herbal decoction for woman aliment? Phytomedicine, 20: 1076-1081.
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220:   Zhang, X.X., X.H. Chen, T.X. Dong, K.W. Tsim, X.D. Wang and K.S. Bi, 2006. Determination of organochlorine pesticide residues in Radix Codonopsis and Radix Gentianae by solid-phase extraction and capillary gas chromatography. J. Shenyang Pharm. Univ., 23: 776-781.
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221:   Zhao, K.J., M. Zhong, E.L. Yang, T.T.X. Dong and K.W.K. Tsim, 2006. Effect of drug ratio changes of Radix Angelicae Sinensis to Radix Astragali in Danggui Buxue Tang (DBT) on the contents of constituents. China Pharm., 9: 1032-1034.
222:   Zhao, K.J., M. Zhong, E.L. Yang, T.T.X. Dong and K.W.K. Tsim, 2006. Effect of processing of radix Angelicae sinensis in Danggui Buxue Tang (DBT) on the contents of bioactive constituents. Chin. Traditional Herbal Drugs, 12: 1813-1816.
223:   Zhao, K.J., T.T. Dong, P.F. Tu, Z.H. Song, C.K. Lo and K.W. Tsim, 2003. Molecular genetic and chemical assessment of radix Angelica (Danggui) in China. J. Agric. Food Chem., 51: 2576-2583.
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224:   Zhao, K.J., T.T.X. Dong, C.K. Lo, P.F. Tu and K.W.K. Tsim, 2005. Species identification of Dyers woad leaf by DNA sequences of 5S-rRNA spacer domain and random amplified polymorphic DNA (RAPD). Oriental Pharm. Exp. Med., 5: 117-123.
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225:   Zhao, K.J., T.T.X. Dong, X.M. Cui, P.F. Tu and K.W.K. Tsim, 2003. Genetic distinction of radix adenophorae from its adulterants by the DNA sequence of 5S-rRNA spacer domains. Am. J. Chin Med., 31: 919-926.
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226:   Zhao, K.J., Y.Z. Zheng, T.X. Dong and W.K. Tsim, 2011. Analysis of HPLC fingerprints of fructus aurantii from different habitats and contents of naringin, neohesperidin and synephrine. Chin. Pharm. J., 46: 955-959.
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227:   Zheng, K.Y., A.J. Guo, C.W. Bi, K.Y. Zhu and G.K. Chan et al., 2011. The extract of Rhodiolae Crenulatae Radix et Rhizoma induces the accumulation of HIF-1α via blocking the degradation pathway in cultured kidney fibroblasts. Planta Med., 77: 894-899.
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228:   Zheng, K.Y., R.C. Choi, A.W. Cheung, A.J. Guo and C.W. Bi et al., 2011. Flavonoids from Radix Astragali induce the expression of erythropoietin in cultured cells: A signaling mediated via the accumulation of hypoxia-inducible factor-1α. J. Agric. Food Chem., 59: 1697-1704.
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229:   Zheng, K.Y., R.C. Choi, H.Q. Xie, A.W. Cheung and A.J. Guo et al., 2010. The expression of erythropoietin triggered by Danggui Buxue Tang a Chinese herbal decoction prepared from Radix Astragali and Radix Angelicae Sinensis, is mediated by the hypoxia-inducible factor in cultured HEK293T cells. J. Ethnopharmacol., 132: 259-267.
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230:   Zheng, K.Y.Z., R.C.Y. Choi, A.J.Y. Guo, C.W.C. Bi and K.Y. Zhu et al., 2012. The membrane permeability of Astragali Radix-derived formononetin and calycosin is increased by Angelicae Sinensis Radix in Caco-2 cells: A synergistic action of an ancient herbal decoction Danggui Buxue Tang. J. Pharmaceutical Biomed. Anal., 70: 171-679.
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231:   Zheng, K.Y.Z., Z.X. Zhang, A.J.Y. Guo, C.W.C. Bi and K.Y. Zhu et al., 2012. Salidroside stimulates the accumulation of HIF-1α protein resulted in the induction of EPO expression: A signaling via blocking the degradation pathway in kidney and liver cells. Eur. J. Pharmacol., 679: 34-39.
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232:   Zheng, Y.Z., R.C.Y. Choi, J. Li, H.Q.H. Xie and A.W.H. Cheung et al., 2010. Ligustilide suppresses the biological properties of Danggui Buxue Tang: A Chinese herbal decoction composed of radix astragali and radix angelica sinensis. Planta Med., 76: 439-443.
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233:   Zhou, H., T. Muramatsu, W. Halfter, K.W. Tsim and H.B. Peng, 1997. A role of midkine in the development of the neuromuscular junction. Mol. Cell. Neurosci., 10: 56-70.
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234:   Zhu, H., W. Gao, H. Jiang, Y.F. Shi, K.W.K. Tsim and X.J. Zhang, 2007. Regulation of acetylcholinesterase expression by calcium signaling during calcium ionophore A23187-and thapsigargin-induced apoptosis. Int. J. Biochem. Cell. Biol., 39: 93-108.
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235:   Zhu, J.T.T., R.C.Y. Choi, H.Q.H. Xie, K.Y.Z. Zheng and A.J.Y. Guo et al., 2009. Hibifolin, a flavonol glycoside, prevents β-amyloid-induced neurotoxicity in cultured cortical neurons. Neurosci. Lett., 461: 172-176.
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236:   Zhu, J.T.T., R.C.Y. Choi, J. Li, H.Q. Xie and C.W.C. Bi et al., 2009. Estrogenic and neuroprotective properties of scutellarin from Erigeron breviscapus: A drug against postmenopausal symptoms and Alzheimer's disease. Planta Med., 75: 1489-1493.
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237:   Zhu, J.T.Y., R.C. Choi, G.K. Chu, A.W. Cheung and Q.T. Gao,et al., 2007. Flavonoids possess neuroprotective effects on cultured pheochromocytoma PC12 cells: a comparison of different flavonoids in activating estrogenic effect and in preventing beta-amyloid-induced cell death. J. Agric. Food Chem., 55: 2438-2445.
PubMed  |  Direct Link  |  
238:   Zhu, K.Y., K.W. Leung, A.K. Ting, Z.C. Wong and Q. Fu et al., 2011. The establishment of a highly sensitive method in detecting ketamine and norketamine simultaneously in human hairs by HPLC-Chip-MS/MS. Forensic Sci. Int., 208: 53-58.
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239:   Zhu, K.Y., K.W. Leung, A.K. Ting, Z.C. Wong and W.Y. Ng et al., 2012. Microfluidic chip based nano liquid chromatography coupled to tandem mass spectrometry for the determination of abused drugs and metabolites in human hair. Anal. Bioanal. Chem., 402: 2805-2815.
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240:   Zhu, K.Y., Q. Fu, H.Q. Xie, S.L. Xu and A.W. Cheung et al., 2010. Quality assessment of a formulated Chinese herbal decoction, Kaixinsan, by using rapid resolution liquid chromatography coupled with mass spectrometry: A chemical evaluation of different historical formulae. J. Separation Sci., 33: 3666-3674.
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241:   Zhu, K.Y., Q. Fu, K.W. Leung, Z.C. Wong, R.C. Choi and K.W. Tsim, 2011. The establishment of a sensitive method in determining different neurotransmitters simultaneously in rat brains by using liquid chromatography-electrospray tandem mass spectrometry. J. Chromatography B, 879: 737-742.
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242:   Zhu, K.Y., Q.Q. Mao, S.P. Ip, R.C.Y. Choi and T.T.X. Dong et al., 2012. A standardized chinese herbal decoction, kai-xin-san, restores decreased levels of neurotransmitters and neurotrophic factors in the brain of chronic stress-induced depressive rats. Evid. Based Complement. Alternat. Med., Vol. 2012. 10.1155/2012/149256.
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243:   Zhu, K.Y., S.L. Xu, R.C.Y. Choi, A.L. Yan, T.T.X. Dong and K.W.K. Tsim, 2013. Kai-Xin-San, a Chinese herbal decoction containing Ginseng Radix et Rhizoma, Polygalae Radix, Acori Tatarinowii Rhizoma and Poria, stimulates the expression and secretion of neurotrophic factors in cultured astrocytes. Evidence Based Complementary Alternative Med., Vol. 2013. 10.1155/2013/731385.
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244:   Zou, X.H., H.Q. Xie, G.C. Zha, V.P. Chen and Y.J. Sun et al., 2013. Characterizations of cholinesterases in golden apple snail (Pomacea canaliculata). J. Mol. Neurosci. 10.1007/s12031-013-0168-4.
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