Dr. Cheng  Wang

Dr. Cheng Wang

Medical Professional/Doctor
National Center for Toxicological Research, USA


Highest Degree
Ph.D. in Neurobiology from Geneva University, Switzerland

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Area of Interest:

Pharmacology and Toxicology
100%
Neuroscience
62%
Pharmacology
90%
Toxicology
75%
Nanomedicine
55%

Selected Publications

  1. Zhang, X., S. Liu, M.G. Paule, G.D. Newport and R. Callicott et al., 2013. Protective effects of acetyl L-carnitine on inhalation anesthetic-induced neuronal damage in the nonhuman primate. J. Mol. Pharm. Organic Process Res., 1: 1-7.

  2. Zhang, X., M.G. Paule, C. Wang and W. Slikker, 2013. Application of microPET imaging approaches in the study of pediatric anesthetic-induced neuronal toxicity. J. Applied Toxicol., 33: 361-868.
    CrossRef  |  

  3. Zhang, X., G.D. Newport, M.G. Paule, S. Liu and M. Berridge et al., 2013. Quantitative assessment of acetyl-carnitine effects on anesthetic-induced neuronal death using microPET/CT imaging. J. Drug Alcohol Res., Vol. 2. 10.4303/jdar/235653.
    CrossRef  |  

  4. Wang, C., F. Liu, T.A. Patterson, M.G. Paule and W. Slikker, 2013. Utilization of neural stem cell-derived models to study anesthesia-related toxicity and protection. Mol. Neurobiol., 48: 302-307.

  5. Wang, C., F. Liu, T.A. Patterson, M.G. Paule and W. Slikker, 2013. Preclinical assessment of ketamine. CNS Neurosci. Ther., 19: 448-453.
    CrossRef  |  

  6. Wang, C., 2013. Critical regulation of calcium signaling and NMDA-type glutamate receptor in developmental neural toxicity (Expert review article). J. Drug Metab. Toxicol., Vol. 4. 10.4172/2157-7609.1000151.
    CrossRef  |  

  7. Liu, S., M.G. Paule, X. Zhang, G.D. Newport and S.M. Apana et al., 2013. The Evaluation of sevoflurane-induced apoptotic neuro-degeneration with microPET using [18F]-DFNSH in the developing rat brain. J. Drug Alcohol Res., Vol. 2. 10.4303/jdar/235679.
    CrossRef  |  

  8. Liu, F., T.A. Patterson, N. Sadovova, X. Zhang and S. Liu et al., 2013. Ketamine-induced neuronal damage and altered N-methyl-D-aspartate (NMDA) receptor function in rat primary forebrain culture. Toxicol. Sci., 131: 548-557.
    CrossRef  |  

  9. Zhang, X., M.G. Paule, G.D. Newport, F. Liu and R. Callicott et al., 2012. MicroPET/CT imaging of [18F]-FEPPA in the nonhuman primate: A potential biomarker of pathogenic processes associated with anesthetic-induced neurotoxicity. ISRN Anesthesiol., Vol. 2012. 10.5402/2012/261640.
    CrossRef  |  

  10. Xia, Q., H.M. Chiang, Y.T. Zhou, J.J. Yin and F. Liu et al., 2012. Phototoxicity of kava-Formation of reactive oxygen species leading to lipid peroxidation and DNA damage. Am. J. Chin. Med., 40: 1271-1288.
    CrossRef  |  

  11. Wang, C., M.G. Paule, F. Liu, T.A. Patterson and W. Slikker, 2012. Nonhuman primate models and developmental neuronal toxicity. J. Drug Metabolism Toxicol., Vol. 3. 10.4172/2157-7609.1000e113.
    CrossRef  |  

  12. Liu, F., X. Zhang, T.A. Patterson, S. Liu and S.F. Ali et al., 2012. Assessment of potential neuronal toxicity of inhaled anesthetics in the developing nonhuman primate. J. Drug Alcohol Res., 1: 1-9.
    CrossRef  |  

  13. Liu, F., L. Guo, J. Zhang, S.W. Rainosek and L. Shi et al., 2012. Inhalation anesthesia-induced neuronal damage and gene expression changes in developing rat brain. Syst. Pharmacol., 1: 1-9.
    Direct Link  |  

  14. Chiang, H.M., Q. Xia, X. Zou, C. Wang and S. Wang et al., 2012. Nanoscale ZnO induces cytotoxicity and DNA damage in human cell lines and rat primary neuronal cells. J. Nanosci. Nanotechnol., 12: 2126-2135.
    CrossRef  |  

  15. Cheng, W., 2012. Advanced pre-clinical research approaches and models to studying pediatric anesthetic neurotoxicity. Frontiers Neurol., Vol. 3. 10.3389/fneur.2012.00142.
    CrossRef  |  

  16. Zou, X., F. Liu, X. Zhang, T.A. Patterson and R. Callicott et al., 2011. Inhalation anesthetic-induced neuronal degeneration in the developing rhesus monkey. Neurotoxicol. Teratol., 33: 592-597.
    CrossRef  |  

  17. Zhang, X., T.A. Patterson, M.G. Paule, W. Slikker and C. Wang, 2011. Neurotoxic Effects of Anesthetics and Potential Protective Agents. In: Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies and Mechanisms, Wang, C. and W. Slikker (Eds.). John Wiley and Sons, New York, pp: 79-94.

  18. Zhang, X., M.G. Paule, G.D. Newport, N. Sadovova and M.S. Berridge et al., 2011. MicroPET imaging of ketamine-induced neuronal apoptosis with radiolabeled DFNSH. J. Neural. Trans., 118: 203-211.
    CrossRef  |  

  19. Wang, C., X. Zhang, F. Liu, M.G. Paule and W. Slikker, 2011. Alterations in N-methyl-D-aspartate (NMDA) receptor function and potential involvement in anesthetic-induced neurodegeneration. Brain Res. J., 3: 155-172.

  20. Wang, C., M.G. Paule, F. Liu and W. Slikker, 2011. Application of systems biology in developmental neuronal toxicity. J. Drug Metabolism Toxicol., Vol. 2. 10.4172/2157-7609.1000e101.
    CrossRef  |  

  21. Wang, C., L. Guo, T. Patterson and W. Slikker, 2011. Application of Systems Biology in Neurotoxicological Studies during Development. Wiley-Blackwell Publisher, New York, pp: 115-123.

  22. Wang, C. and W. Slikker, 2011. Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies and Mechanisms. John Wiley and Sons, New York.

  23. Slikker, W., X. Zhang, F. Liu, M.G. Paule and C. Wang, 2011. Approaches and Models for Evaluating the Toxic Effects of Anesthetics in the Developing Nervous System. In: Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies and Mechanisms, Wang, C. and W. Slikker (Eds.). John Wiley and Sons, New York, pp: 5-24.

  24. Slikker, W., F. Liu, X. Zhang, X. Zou, T.A. Patterson, M.G. Paule and C. Wang, 2011. Perinatal Rhesus Monkey Models and Anesthetic-induced Neuronal Cell Death. In: Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies and Mechanisms, Wang, C. and W. Slikker (Eds.). John Wiley and Sons, New York, pp: 95-110.

  25. Patterson, T.A., B.J. Schnackenberg, W. Slikker and C. Wang, 2011. Systems Biology Approaches to Neurotoxicity Studies during Development. In: Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies and Mechanisms, Wang, C. and W. Slikker (Eds.). John Wiley and Sons, New York, pp: 25-38.

  26. Liu, F., N. Sadovova, X. Zhang, L. Shi and L. Guo et al., 2011. Changes in gene expression after phencyclidine administration in developing rats: A potential animal model of schizophrenia. Int. J. Dev. Neurosci., 29: 351-358.
    CrossRef  |  

  27. Liu, F., M.G. Paule, S. Ali and C. Wang, 2011. Ketamine-induced neurotoxicity and changes in gene expression in the developing rat brain. Curr. Neuropharmacol., 9: 256-261.
    Direct Link  |  

  28. Wang, C., X. Zhang, F. Liu, M.G. Paule and W. Slikker, 2010. Anesthetic-induced Oxidative stress and potential protection (mini-review). Sci. World J., 10: 1472-1482.

  29. Shi, Q., L. Guo, T.A. Patterson, S. Dial and Q. Li et al., 2010. Gene expression profiling in the developing rat brain exposed to ketamine. Neuroscience, 166: 852-863.
    CrossRef  |  

  30. Zou, X., T.A. Patterson, R.L. Divine, N. Sadovova and X. Zhang et al., 2009. Prolonged exposure to ketamine increases neurodegeneration in the developing monkey brain. Int. J. Dev. Neurosci., 27: 727-731.
    CrossRef  |  

  31. Zou, X., T.A. Patterson, N. Sadovova, N.C. Twaddle and D.R. Doerge et al., 2009. Potential neurotoxicity of ketamine in the developing rat brain. Toxicol. Sci., 108: 149-158.
    CrossRef  |  

  32. Zhang, X., M.G. Paule, G.D. Newport, X. Zou and N. Sadovova et al., 2009. A minimally invasive, translational biomarker of ketamine-induced neuronal death in rats: MicroPET Imaging using 18F-annexin V. Toxicol. Sci., 111: 355-361.
    CrossRef  |  

  33. Zou, X., N. Sadovova, T.A. Patterson, R.L. Divine and C.E. Hotchkiss et al., 2008. The effects of L-carnitine on the combination of inhalation anesthetic-induced developmental neuronal apoptosis in the rat frontal cortex. Neuroscience, 151: 1053-1065.
    CrossRef  |  

  34. Zhang, X., T. Patterson, M. Paule, W. Slikker and C. Wang, 2008. The role of NMDA glutamate receptors in pain and anesthetic-induced neurodegeneration during development (chapter review). Amino Acid Receptor Res., 1: 191-213.

  35. Wang, C., X. Zhang, G.M. Paule and W. Slikker, 2008. Ketamine and glutamate receptors: Potential toxicity of general anesthetics during rapid brain development (review). Central Nervous Syst. Agents Med. Chem., 8: 85-91.

  36. Wang, C., T.A. Patterson, N. Sadovova, X. Zou and X. Fu et al., 2008. Protective effects of 7-Nitroindazole on Ketamine-induced neurotoxicity in rat forebrain culture. Neurotoxicology, 29: 613-620.
    CrossRef  |  

  37. Wang, C. and W. Slikker, 2008. Strategies and experimental models for evaluating anesthetics: Effects on the developing nervous system (Special Article). Anesthesia Analgesia, 106: 1643-1658.
    CrossRef  |  

  38. Boctor, S.Y., C. Wang and S.A. Ferguson, 2008. Neonatal PCP is more potent than ketamine at modifying preweaning behaviors of Sprague-Dawley rats. Toxicol. Sci., 106: 172-179.
    CrossRef  |  

  39. Wang, C., N. Sadovova, H. Ali, X. Fu and A.C. Scallet et al., 2007. L-Carnitine protects neurons from 1-methyl-4-phenylpyridinium (MPP+)-induced neuronal apoptosis in rat forebrain culture. Neuroscience, 144: 46-55.

  40. Wang, C., M.G. Paule, L.K.M. Wright, T.A. Patterson and W. Slikker, 2007. Application of pharmacogenomics to rodent and Non-human primate neuro-plasticity and -toxicity during development. Evolutionary Mol. Strategies Plasticity Res., 37/661: 1-36.

  41. Slikker, W., X. Zou, C.E. Hotchkiss, R.L. Divine and N. Sadovova, 2007. Ketamine-induced neurodegeneration in the perinatal rhesus monkey. Toxicol. Sci., 98: 145-158.
    CrossRef  |  

  42. Slikker, W., M.G. Paule, L.K.M. Wright, T.A. Patterson and C. Wang, 2007. Systems biology approaches for toxicology (Review). J. Applied Toxicol., 27: 201-217.

  43. Hotchkiss, C.E., C. Wang and W. Slikker, 2007. The effect of prolonged ketamine exposure on cardiovascular physiology in pregnant and infant rhesus monkeys (Macaca mulatta). J. Am. Assoc. Lab. Anim. Sci., 46: 21-28.
    PubMed  |  

  44. Wang, C., N. Sadovova, C. Hotchkiss, X. Fu and A.C. Scallet et al., 2006. Blockade of N-Methyl-D-Aspartate (NMDA) receptors by ketamine produces loss of postnatal day 3 (PND-3) monkey frontal cortical neurons in culture. Toxicol. Sci., 91: 192-201.
    Direct Link  |  

  45. Wang, C., N. Sadovova, X. Fu, A. Scallet, J. Hanig and W. Slikker, 2005. The role of NMDA receptors in ketamine-induced apoptosis in rat forebrain culture. Neuroscience, 132: 967-977.

  46. Wang, C., J. Fridley and K.M. Johnson, 2005. The role of NMDA receptor upregulation in phencyclidine-induced cortical apoptosis in organotypic culture. Biochem. Pharmacol., 69: 1373-1383.
    CrossRef  |  

  47. Slikker, W., Z. Xu and C. Wang, 2005. Application of a systems biology approach to developmental neurotoxicology (Review). Reproductive Toxicol., 19: 305-319.
    CrossRef  |  

  48. Wang, C., N. Anastasio, V.L. Popov, A. LeDay and K.M. Johnson, 2004. Blockade of N-Methyl-D-Aspartate Receptors by phencyclidine causes the loss of corticostriatal neurons. Neuroscience, 125: 473-483.
    CrossRef  |  

  49. Lee, H.M., Z. Hu, H. Ma, G.H. Greeley, C. Wang and E.W. Englander, 2004. Developmental changes in expression and subcellular localization of the DNA repair glycosylase, MYH, in the rat brain. J. Neurochem., 88: 394-400.
    CrossRef  |  

  50. Wang, C., J. McInnis, B. West, J. Bao and N.C. Anastasio et al., 2003. Blockade of phencyclidine-induced cortical apoptosis and deficits in prepulse inhibition by M40403, a superoxide dismutase mimetic. J. Pharmacol. Exp. Ther., 304: 266-272.
    PubMed  |  

  51. Barral-Moran, M.J., V. Calaora, L. Vutskits, C. Wang and H. Zhang et al., 2003. Oligodendrocyte progenitor migration in response to injury of glial monolayers requires the polysialic neural cell-adhesion molecule. J. Neurosci. Res., 72: 679-690.
    CrossRef  |  

  52. Yu, B., C. Wang, J. Liu, K.M. Johnson and J.P. Gallagher, 2002. Adaptation to chronic PCP results in hyperfunctional NMDA and hypofunctional GABAA synaptic receptors. Neuroscience, 113: 1-10.
    CrossRef  |  

  53. McInnis, J., C. Wang, N. Anastasio, M. Hultman, Y. Ye, D. Salvemini and K.M. Johnson, 2002. The role of superoxide and nuclear factor-kappaB signaling in N-methyl-D-aspartate-induced necrosis and apopt. J. Pharmacol. Exp. Ther., 301: 478-487.
    PubMed  |  

  54. Lee, H.M., C. Wang, Z. Hu, G.H. Greeley, W. Makalowski, H.J. Hellmich and E.W. Englander, 2002. Hypoxia induces mitochondrial DNA damage and stimulates expression of a DNA repair enzyme, the E. COLI DNA glycosylase homolog, in vivo, in the rat brain. J. Neurochem., 80: 928-937.
    CrossRef  |  

  55. Ye, Y.M., C. Wang, P.F. Du, P.K. Seitz and C.W. Cooper, 2001. Overexpression of parathyroid hormone-related protein enhances apoptosis in the rat intestinal crypt cell line, IEC-61. Endocriology, 142: 1906-1914.
    CrossRef  |  

  56. Xie, J., C. Wang, J.M. Chung and K. Chung, 2001. Differential expression of Alpha 1-adrenoreceptor subtype mRNAs in the dorsal root ganglion (DRG) after spinal nerve ligation. Molecular Brain Res., 93: 164-172.
    CrossRef  |  

  57. Wang, C., J. McInnis, M.R. Sanchez, P. Shinnick-Gallagher, L. Wiley and K.M. Johnson, 2001. Long-term behavioral and neurodegenerative effects of perinatal phencyclidine administration: Implications for schizophrenia. Neuroscience, 107: 535-550.
    CrossRef  |  

  58. Phillips, M., C. Wang and K.M. Johnson, 2001. Pharmacological characterization of locomotor sensitization induced by chronic phencyclidine administration. J. Pharmacol. Exp. Ther., 296: 905-913.
    PubMed  |  

  59. Wang, C., J.A. Kaufmann, M.G. Sanchez-Ross and K.M. Johnson, 2000. Mechanisms of N-Methyl-D-Aspartate-induced apoptosis in phencyclidine treated cultured forebrain neurons. J. Pharmacol. Exp. Ther., 294: 287-295.
    PubMed  |  

  60. Du, P.F., Y.M. Ye, P.K. Seitz, L.X. Bi and H. Li et al., 2000. Endogenous parathyroid hormone-related peptide enhances proliferation and inhibits differentiation in the osteoblastic-like cell line ROS 17/2.8. Bone, 26: 429-436.
    PubMed  |  

  61. Wang, C., V.M. Showalter, G.R. Hillman and K.M. Johnson, 1999. Chronic phencyclidine increase NMDA receptor NR1 subunit mRNA in rat forebrain. J. Neurosci. Res., 55: 762-769.
    CrossRef  |  

  62. Johnson, K.M., M. Phillips, C. Wang and G.A. Kevetter, 1998. Chronic phencyclidine induces behavioral sensitization and apoptotic cell death in olfactory and piriform cortex. J. Neurosci. Res., 52: 709-722.
    CrossRef  |  

  63. Wang, C., W.F. Pralong, M.F. Schulz, G. Rougon and J.M. Aubry et al., 1996. Functional N-Methyl-D-Aspartate receptors in O-2A glial precursor cells: A critical role in regulating polysialic acid-neural cell adhesion molecule expression and cell migration. J. Cell. Biol., 135: 1565-1581.
    PubMed  |  

  64. Pan, G., H. Cui, X. Du, Z. Wu and H. Li et al., 1996. Atlas of Ultrastructure in Human Fetal Organs. Science of Hei-Longjiang Publisher, USA.

  65. Muller, D., C. Wang, G. Skibo, N. Toni and H. Gremer et al., 1996. PSA-NCAM is required for activity-induced synaptic plasticity. Neuron, 17: 413-422.
    PubMed  |  

  66. Wang, C., G. Rougon and J.Z. Kiss, 1994. Requirement of polysialic acid for the migration of the O-2A glial progenitor cell from neurohypophyseal explants. J. Neuroscience, 14: 4446-4457.
    PubMed  |  

  67. Muller, D,, L. Stoppini, C. Wang and J.Z. Kiss, 1994. A role for polysialylated neural cell adhesion molecule in lesion-induced sprouting in hippocampal organotypic cultures. Neuroscience, 61: 441-445.
    PubMed  |  

  68. Kiss, J.Z., C. Wang, S. Olive, G. Rougon, J. Lang, D. Baetens, D. Harry and W.F. Pralong, 1994. Activity-dependent mobilization of the adhesion molecule polysialic NCAM to the cell surface of neurons and endocrine cells. EMBO J., 13: 5284-5292.
    Direct Link  |  

  69. Kiss, J.Z., C. Wang and G. Rougon, 1993. Nerve-dependent expression of high polysialic acid neural cell adhesion molecule in neurohypophysial astrocytes of adult rats. Neuroscience, 53: 213-221.
    CrossRef  |  

  70. Wang, C., Y.Q. Hou and F. Xu, 1986. Ultrastructure of hypothalamic arcuate nucleus in rats. J. Harbin Medical Univ., 1: 9-11.