Hi, I am Cheng Wang, My LiveDNA is 86.5974
 
   
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Dr. Cheng Wang
 
Highest Degree: Ph.D. in Neurobiology from Geneva University, Switzerland
 
Institute: National Center for Toxicological Research, USA
 
Area of Interest: Pharmacology and Toxicology
  •   Neuroscience
  •   Pharmacology
  •   Toxicology
  •   Nanomedicine
 
URL: http://livedna.org/86.5974
 
My SELECTED Publications
1:   Barral-Moran, M.J., V. Calaora, L. Vutskits, C. Wang and H. Zhang et al., 2003. Oligodendrocyte progenitor migration in response to injury of glial monolayers requires the polysialic neural cell-adhesion molecule. J. Neurosci. Res., 72: 679-690.
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2:   Boctor, S.Y., C. Wang and S.A. Ferguson, 2008. Neonatal PCP is more potent than ketamine at modifying preweaning behaviors of Sprague-Dawley rats. Toxicol. Sci., 106: 172-179.
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3:   Cheng, W., 2012. Advanced pre-clinical research approaches and models to studying pediatric anesthetic neurotoxicity. Frontiers Neurol., Vol. 3. 10.3389/fneur.2012.00142.
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4:   Chiang, H.M., Q. Xia, X. Zou, C. Wang and S. Wang et al., 2012. Nanoscale ZnO induces cytotoxicity and DNA damage in human cell lines and rat primary neuronal cells. J. Nanosci. Nanotechnol., 12: 2126-2135.
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5:   Du, P.F., Y.M. Ye, P.K. Seitz, L.X. Bi and H. Li et al., 2000. Endogenous parathyroid hormone-related peptide enhances proliferation and inhibits differentiation in the osteoblastic-like cell line ROS 17/2.8. Bone, 26: 429-436.
PubMed  |  
6:   Hotchkiss, C.E., C. Wang and W. Slikker, 2007. The effect of prolonged ketamine exposure on cardiovascular physiology in pregnant and infant rhesus monkeys (Macaca mulatta). J. Am. Assoc. Lab. Anim. Sci., 46: 21-28.
PubMed  |  
7:   Johnson, K.M., M. Phillips, C. Wang and G.A. Kevetter, 1998. Chronic phencyclidine induces behavioral sensitization and apoptotic cell death in olfactory and piriform cortex. J. Neurosci. Res., 52: 709-722.
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8:   Kiss, J.Z., C. Wang and G. Rougon, 1993. Nerve-dependent expression of high polysialic acid neural cell adhesion molecule in neurohypophysial astrocytes of adult rats. Neuroscience, 53: 213-221.
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9:   Kiss, J.Z., C. Wang, S. Olive, G. Rougon, J. Lang, D. Baetens, D. Harry and W.F. Pralong, 1994. Activity-dependent mobilization of the adhesion molecule polysialic NCAM to the cell surface of neurons and endocrine cells. EMBO J., 13: 5284-5292.
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10:   Lee, H.M., C. Wang, Z. Hu, G.H. Greeley, W. Makalowski, H.J. Hellmich and E.W. Englander, 2002. Hypoxia induces mitochondrial DNA damage and stimulates expression of a DNA repair enzyme, the E. COLI DNA glycosylase homolog, in vivo, in the rat brain. J. Neurochem., 80: 928-937.
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11:   Lee, H.M., Z. Hu, H. Ma, G.H. Greeley, C. Wang and E.W. Englander, 2004. Developmental changes in expression and subcellular localization of the DNA repair glycosylase, MYH, in the rat brain. J. Neurochem., 88: 394-400.
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12:   Liu, F., L. Guo, J. Zhang, S.W. Rainosek and L. Shi et al., 2012. Inhalation anesthesia-induced neuronal damage and gene expression changes in developing rat brain. Syst. Pharmacol., 1: 1-9.
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13:   Liu, F., M.G. Paule, S. Ali and C. Wang, 2011. Ketamine-induced neurotoxicity and changes in gene expression in the developing rat brain. Curr. Neuropharmacol., 9: 256-261.
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14:   Liu, F., N. Sadovova, X. Zhang, L. Shi and L. Guo et al., 2011. Changes in gene expression after phencyclidine administration in developing rats: A potential animal model of schizophrenia. Int. J. Dev. Neurosci., 29: 351-358.
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15:   Liu, F., T.A. Patterson, N. Sadovova, X. Zhang and S. Liu et al., 2013. Ketamine-induced neuronal damage and altered N-methyl-D-aspartate (NMDA) receptor function in rat primary forebrain culture. Toxicol. Sci., 131: 548-557.
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16:   Liu, F., X. Zhang, T.A. Patterson, S. Liu and S.F. Ali et al., 2012. Assessment of potential neuronal toxicity of inhaled anesthetics in the developing nonhuman primate. J. Drug Alcohol Res., 1: 1-9.
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17:   Liu, S., M.G. Paule, X. Zhang, G.D. Newport and S.M. Apana et al., 2013. The Evaluation of sevoflurane-induced apoptotic neuro-degeneration with microPET using [18F]-DFNSH in the developing rat brain. J. Drug Alcohol Res., Vol. 2. 10.4303/jdar/235679.
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18:   McInnis, J., C. Wang, N. Anastasio, M. Hultman, Y. Ye, D. Salvemini and K.M. Johnson, 2002. The role of superoxide and nuclear factor-kappaB signaling in N-methyl-D-aspartate-induced necrosis and apopt. J. Pharmacol. Exp. Ther., 301: 478-487.
PubMed  |  
19:   Muller, D,, L. Stoppini, C. Wang and J.Z. Kiss, 1994. A role for polysialylated neural cell adhesion molecule in lesion-induced sprouting in hippocampal organotypic cultures. Neuroscience, 61: 441-445.
PubMed  |  
20:   Muller, D., C. Wang, G. Skibo, N. Toni and H. Gremer et al., 1996. PSA-NCAM is required for activity-induced synaptic plasticity. Neuron, 17: 413-422.
PubMed  |  
21:   Pan, G., H. Cui, X. Du, Z. Wu and H. Li et al., 1996. Atlas of Ultrastructure in Human Fetal Organs. Science of Hei-Longjiang Publisher, USA.
22:   Patterson, T.A., B.J. Schnackenberg, W. Slikker and C. Wang, 2011. Systems Biology Approaches to Neurotoxicity Studies during Development. In: Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies and Mechanisms, Wang, C. and W. Slikker (Eds.). John Wiley and Sons, New York, pp: 25-38.
23:   Phillips, M., C. Wang and K.M. Johnson, 2001. Pharmacological characterization of locomotor sensitization induced by chronic phencyclidine administration. J. Pharmacol. Exp. Ther., 296: 905-913.
PubMed  |  
24:   Shi, Q., L. Guo, T.A. Patterson, S. Dial and Q. Li et al., 2010. Gene expression profiling in the developing rat brain exposed to ketamine. Neuroscience, 166: 852-863.
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25:   Slikker, W., F. Liu, X. Zhang, X. Zou, T.A. Patterson, M.G. Paule and C. Wang, 2011. Perinatal Rhesus Monkey Models and Anesthetic-induced Neuronal Cell Death. In: Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies and Mechanisms, Wang, C. and W. Slikker (Eds.). John Wiley and Sons, New York, pp: 95-110.
26:   Slikker, W., M.G. Paule, L.K.M. Wright, T.A. Patterson and C. Wang, 2007. Systems biology approaches for toxicology (Review). J. Applied Toxicol., 27: 201-217.
27:   Slikker, W., X. Zhang, F. Liu, M.G. Paule and C. Wang, 2011. Approaches and Models for Evaluating the Toxic Effects of Anesthetics in the Developing Nervous System. In: Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies and Mechanisms, Wang, C. and W. Slikker (Eds.). John Wiley and Sons, New York, pp: 5-24.
28:   Slikker, W., X. Zou, C.E. Hotchkiss, R.L. Divine and N. Sadovova, 2007. Ketamine-induced neurodegeneration in the perinatal rhesus monkey. Toxicol. Sci., 98: 145-158.
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29:   Slikker, W., Z. Xu and C. Wang, 2005. Application of a systems biology approach to developmental neurotoxicology (Review). Reproductive Toxicol., 19: 305-319.
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30:   Wang, C. and W. Slikker, 2008. Strategies and experimental models for evaluating anesthetics: Effects on the developing nervous system (Special Article). Anesthesia Analgesia, 106: 1643-1658.
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31:   Wang, C. and W. Slikker, 2011. Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies and Mechanisms. John Wiley and Sons, New York.
32:   Wang, C., 2013. Critical regulation of calcium signaling and NMDA-type glutamate receptor in developmental neural toxicity (Expert review article). J. Drug Metab. Toxicol., Vol. 4. 10.4172/2157-7609.1000151.
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33:   Wang, C., F. Liu, T.A. Patterson, M.G. Paule and W. Slikker, 2013. Preclinical assessment of ketamine. CNS Neurosci. Ther., 19: 448-453.
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34:   Wang, C., F. Liu, T.A. Patterson, M.G. Paule and W. Slikker, 2013. Utilization of neural stem cell-derived models to study anesthesia-related toxicity and protection. Mol. Neurobiol., 48: 302-307.
35:   Wang, C., G. Rougon and J.Z. Kiss, 1994. Requirement of polysialic acid for the migration of the O-2A glial progenitor cell from neurohypophyseal explants. J. Neuroscience, 14: 4446-4457.
PubMed  |  
36:   Wang, C., J. Fridley and K.M. Johnson, 2005. The role of NMDA receptor upregulation in phencyclidine-induced cortical apoptosis in organotypic culture. Biochem. Pharmacol., 69: 1373-1383.
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37:   Wang, C., J. McInnis, B. West, J. Bao and N.C. Anastasio et al., 2003. Blockade of phencyclidine-induced cortical apoptosis and deficits in prepulse inhibition by M40403, a superoxide dismutase mimetic. J. Pharmacol. Exp. Ther., 304: 266-272.
PubMed  |  
38:   Wang, C., J. McInnis, M.R. Sanchez, P. Shinnick-Gallagher, L. Wiley and K.M. Johnson, 2001. Long-term behavioral and neurodegenerative effects of perinatal phencyclidine administration: Implications for schizophrenia. Neuroscience, 107: 535-550.
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39:   Wang, C., J.A. Kaufmann, M.G. Sanchez-Ross and K.M. Johnson, 2000. Mechanisms of N-Methyl-D-Aspartate-induced apoptosis in phencyclidine treated cultured forebrain neurons. J. Pharmacol. Exp. Ther., 294: 287-295.
PubMed  |  
40:   Wang, C., L. Guo, T. Patterson and W. Slikker, 2011. Application of Systems Biology in Neurotoxicological Studies during Development. Wiley-Blackwell Publisher, New York, pp: 115-123.
41:   Wang, C., M.G. Paule, F. Liu and W. Slikker, 2011. Application of systems biology in developmental neuronal toxicity. J. Drug Metabolism Toxicol., Vol. 2. 10.4172/2157-7609.1000e101.
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42:   Wang, C., M.G. Paule, F. Liu, T.A. Patterson and W. Slikker, 2012. Nonhuman primate models and developmental neuronal toxicity. J. Drug Metabolism Toxicol., Vol. 3. 10.4172/2157-7609.1000e113.
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43:   Wang, C., M.G. Paule, L.K.M. Wright, T.A. Patterson and W. Slikker, 2007. Application of pharmacogenomics to rodent and Non-human primate neuro-plasticity and -toxicity during development. Evolutionary Mol. Strategies Plasticity Res., 37/661: 1-36.
44:   Wang, C., N. Anastasio, V.L. Popov, A. LeDay and K.M. Johnson, 2004. Blockade of N-Methyl-D-Aspartate Receptors by phencyclidine causes the loss of corticostriatal neurons. Neuroscience, 125: 473-483.
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45:   Wang, C., N. Sadovova, C. Hotchkiss, X. Fu and A.C. Scallet et al., 2006. Blockade of N-Methyl-D-Aspartate (NMDA) receptors by ketamine produces loss of postnatal day 3 (PND-3) monkey frontal cortical neurons in culture. Toxicol. Sci., 91: 192-201.
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46:   Wang, C., N. Sadovova, H. Ali, X. Fu and A.C. Scallet et al., 2007. L-Carnitine protects neurons from 1-methyl-4-phenylpyridinium (MPP+)-induced neuronal apoptosis in rat forebrain culture. Neuroscience, 144: 46-55.
47:   Wang, C., N. Sadovova, X. Fu, A. Scallet, J. Hanig and W. Slikker, 2005. The role of NMDA receptors in ketamine-induced apoptosis in rat forebrain culture. Neuroscience, 132: 967-977.
48:   Wang, C., T.A. Patterson, N. Sadovova, X. Zou and X. Fu et al., 2008. Protective effects of 7-Nitroindazole on Ketamine-induced neurotoxicity in rat forebrain culture. Neurotoxicology, 29: 613-620.
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49:   Wang, C., V.M. Showalter, G.R. Hillman and K.M. Johnson, 1999. Chronic phencyclidine increase NMDA receptor NR1 subunit mRNA in rat forebrain. J. Neurosci. Res., 55: 762-769.
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50:   Wang, C., W.F. Pralong, M.F. Schulz, G. Rougon and J.M. Aubry et al., 1996. Functional N-Methyl-D-Aspartate receptors in O-2A glial precursor cells: A critical role in regulating polysialic acid-neural cell adhesion molecule expression and cell migration. J. Cell. Biol., 135: 1565-1581.
PubMed  |  
51:   Wang, C., X. Zhang, F. Liu, M.G. Paule and W. Slikker, 2010. Anesthetic-induced Oxidative stress and potential protection (mini-review). Sci. World J., 10: 1472-1482.
52:   Wang, C., X. Zhang, F. Liu, M.G. Paule and W. Slikker, 2011. Alterations in N-methyl-D-aspartate (NMDA) receptor function and potential involvement in anesthetic-induced neurodegeneration. Brain Res. J., 3: 155-172.
53:   Wang, C., X. Zhang, G.M. Paule and W. Slikker, 2008. Ketamine and glutamate receptors: Potential toxicity of general anesthetics during rapid brain development (review). Central Nervous Syst. Agents Med. Chem., 8: 85-91.
54:   Wang, C., Y.Q. Hou and F. Xu, 1986. Ultrastructure of hypothalamic arcuate nucleus in rats. J. Harbin Medical Univ., 1: 9-11.
55:   Xia, Q., H.M. Chiang, Y.T. Zhou, J.J. Yin and F. Liu et al., 2012. Phototoxicity of kava-Formation of reactive oxygen species leading to lipid peroxidation and DNA damage. Am. J. Chin. Med., 40: 1271-1288.
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56:   Xie, J., C. Wang, J.M. Chung and K. Chung, 2001. Differential expression of Alpha 1-adrenoreceptor subtype mRNAs in the dorsal root ganglion (DRG) after spinal nerve ligation. Molecular Brain Res., 93: 164-172.
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57:   Ye, Y.M., C. Wang, P.F. Du, P.K. Seitz and C.W. Cooper, 2001. Overexpression of parathyroid hormone-related protein enhances apoptosis in the rat intestinal crypt cell line, IEC-61. Endocriology, 142: 1906-1914.
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58:   Yu, B., C. Wang, J. Liu, K.M. Johnson and J.P. Gallagher, 2002. Adaptation to chronic PCP results in hyperfunctional NMDA and hypofunctional GABAA synaptic receptors. Neuroscience, 113: 1-10.
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59:   Zhang, X., G.D. Newport, M.G. Paule, S. Liu and M. Berridge et al., 2013. Quantitative assessment of acetyl-carnitine effects on anesthetic-induced neuronal death using microPET/CT imaging. J. Drug Alcohol Res., Vol. 2. 10.4303/jdar/235653.
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60:   Zhang, X., M.G. Paule, C. Wang and W. Slikker, 2013. Application of microPET imaging approaches in the study of pediatric anesthetic-induced neuronal toxicity. J. Applied Toxicol., 33: 361-868.
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61:   Zhang, X., M.G. Paule, G.D. Newport, F. Liu and R. Callicott et al., 2012. MicroPET/CT imaging of [18F]-FEPPA in the nonhuman primate: A potential biomarker of pathogenic processes associated with anesthetic-induced neurotoxicity. ISRN Anesthesiol., Vol. 2012. 10.5402/2012/261640.
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62:   Zhang, X., M.G. Paule, G.D. Newport, N. Sadovova and M.S. Berridge et al., 2011. MicroPET imaging of ketamine-induced neuronal apoptosis with radiolabeled DFNSH. J. Neural. Trans., 118: 203-211.
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63:   Zhang, X., M.G. Paule, G.D. Newport, X. Zou and N. Sadovova et al., 2009. A minimally invasive, translational biomarker of ketamine-induced neuronal death in rats: MicroPET Imaging using 18F-annexin V. Toxicol. Sci., 111: 355-361.
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64:   Zhang, X., S. Liu, M.G. Paule, G.D. Newport and R. Callicott et al., 2013. Protective effects of acetyl L-carnitine on inhalation anesthetic-induced neuronal damage in the nonhuman primate. J. Mol. Pharm. Organic Process Res., 1: 1-7.
65:   Zhang, X., T. Patterson, M. Paule, W. Slikker and C. Wang, 2008. The role of NMDA glutamate receptors in pain and anesthetic-induced neurodegeneration during development (chapter review). Amino Acid Receptor Res., 1: 191-213.
66:   Zhang, X., T.A. Patterson, M.G. Paule, W. Slikker and C. Wang, 2011. Neurotoxic Effects of Anesthetics and Potential Protective Agents. In: Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies and Mechanisms, Wang, C. and W. Slikker (Eds.). John Wiley and Sons, New York, pp: 79-94.
67:   Zou, X., F. Liu, X. Zhang, T.A. Patterson and R. Callicott et al., 2011. Inhalation anesthetic-induced neuronal degeneration in the developing rhesus monkey. Neurotoxicol. Teratol., 33: 592-597.
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68:   Zou, X., N. Sadovova, T.A. Patterson, R.L. Divine and C.E. Hotchkiss et al., 2008. The effects of L-carnitine on the combination of inhalation anesthetic-induced developmental neuronal apoptosis in the rat frontal cortex. Neuroscience, 151: 1053-1065.
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69:   Zou, X., T.A. Patterson, N. Sadovova, N.C. Twaddle and D.R. Doerge et al., 2009. Potential neurotoxicity of ketamine in the developing rat brain. Toxicol. Sci., 108: 149-158.
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70:   Zou, X., T.A. Patterson, R.L. Divine, N. Sadovova and X. Zhang et al., 2009. Prolonged exposure to ketamine increases neurodegeneration in the developing monkey brain. Int. J. Dev. Neurosci., 27: 727-731.
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